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Overview

ID MAG03362
Name SHD1_bin.1
Sample SMP0082
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Gallionellaceae
Genus
Species
Assembly information
Completeness (%) 79.68
Contamination (%) 1.91
GC content (%) 58.0
N50 (bp) 13,042
Genome size (bp) 2,056,923

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2114

Gene name Description KEGG GOs EC E-value Score Sequence
SHD1_k127_1001491_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 1.206e-307 960.0
SHD1_k127_1001491_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 3.131e-300 928.0
SHD1_k127_1001491_10 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 374.0
SHD1_k127_1001491_11 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 364.0
SHD1_k127_1001491_12 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 359.0
SHD1_k127_1001491_13 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 319.0
SHD1_k127_1001491_14 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 318.0
SHD1_k127_1001491_15 rod shape-determining protein MreD K03571 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002001 262.0
SHD1_k127_1001491_16 Transposase IS200 like K07491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003346 244.0
SHD1_k127_1001491_17 PFAM PTS system fructose subfamily IIA component K02821 - 2.7.1.194 0.00000000000000000000000000000000000000000000000747 175.0
SHD1_k127_1001491_18 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000009196 153.0
SHD1_k127_1001491_19 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000004575 140.0
SHD1_k127_1001491_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.969e-290 898.0
SHD1_k127_1001491_20 OmpA-like transmembrane domain K03286 - - 0.0000000000001315 78.0
SHD1_k127_1001491_3 PFAM major facilitator superfamily MFS_1 K08218 - - 4.894e-230 717.0
SHD1_k127_1001491_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 8.506e-222 692.0
SHD1_k127_1001491_5 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 4.712e-213 665.0
SHD1_k127_1001491_6 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 1.362e-206 645.0
SHD1_k127_1001491_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 1.749e-197 625.0
SHD1_k127_1001491_8 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 559.0
SHD1_k127_1001491_9 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005347 410.0
SHD1_k127_104472_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0 1100.0
SHD1_k127_104472_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 2.515e-279 863.0
SHD1_k127_104472_10 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001518 280.0
SHD1_k127_104472_11 TIGRFAM outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004925 277.0
SHD1_k127_104472_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000000000000000000008959 167.0
SHD1_k127_104472_2 TIGRFAM outer membrane autotransporter barrel domain protein - - - 6.622e-268 879.0
SHD1_k127_104472_3 Ammonium Transporter Family K03320,K06580 - - 1.195e-243 754.0
SHD1_k127_104472_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 1.09e-238 745.0
SHD1_k127_104472_5 - - - - 2.644e-236 755.0
SHD1_k127_104472_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 310.0
SHD1_k127_104472_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004877 310.0
SHD1_k127_104472_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 311.0
SHD1_k127_104472_9 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 290.0
SHD1_k127_1082216_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 4.285e-269 837.0
SHD1_k127_1082216_1 Carbon starvation protein CstA K06200 - - 6.274e-242 752.0
SHD1_k127_1082216_2 Ribosomal protein L31 K02909 - - 0.00000000000000000000000000000000000006802 147.0
SHD1_k127_1082216_3 Selenoprotein, putative - - - 0.00000000000006527 74.0
SHD1_k127_1117412_0 PFAM membrane bound O-acyl transferase MBOAT family protein K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 604.0
SHD1_k127_1117412_1 O-antigen ligase like membrane protein K02847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 579.0
SHD1_k127_1117412_2 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 515.0
SHD1_k127_1117412_3 Glycosyltransferase Family 4 K02844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 482.0
SHD1_k127_1117412_4 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 457.0
SHD1_k127_1117412_5 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 316.0
SHD1_k127_1117412_6 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 305.0
SHD1_k127_1117412_7 O-Antigen ligase K02847 - - 0.000000000000000000000000000000000000000000000000005116 190.0
SHD1_k127_1176706_0 ATPase (P-type) K01535 - 3.6.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009627 510.0
SHD1_k127_1176706_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 383.0
SHD1_k127_1176706_2 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000002139 137.0
SHD1_k127_1195680_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1241.0
SHD1_k127_1195680_1 Protein of unknown function - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002129 282.0
SHD1_k127_1195680_2 PFAM Adenylyl cyclase class-3 4 guanylyl cyclase K01769 - 4.6.1.2 0.0000000000000000000000000000000000000000000000000000001141 199.0
SHD1_k127_1266648_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.0 1024.0
SHD1_k127_1266648_1 NeuB family K03856 - 2.5.1.54 6.421e-206 642.0
SHD1_k127_1266648_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 1.623e-200 627.0
SHD1_k127_1266648_3 Chorismate mutase type II K01713,K14170 - 4.2.1.51,4.2.1.91,5.4.99.5 2.146e-196 615.0
SHD1_k127_1266648_4 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 576.0
SHD1_k127_1266648_5 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 475.0
SHD1_k127_1266648_6 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 419.0
SHD1_k127_1266648_7 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 312.0
SHD1_k127_1266648_8 - - - - 0.0000000000000000000000000000000002898 138.0
SHD1_k127_1266648_9 Flagellar regulator YcgR - - - 0.0000000000007212 78.0
SHD1_k127_12839_0 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009534 464.0
SHD1_k127_12839_1 beta-lactamase domain protein K01120 - 3.1.4.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 386.0
SHD1_k127_12839_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 304.0
SHD1_k127_12839_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 291.0
SHD1_k127_12839_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000002816 233.0
SHD1_k127_12839_5 PFAM Class I peptide chain release factor K15034 - - 0.000000000000000000000000000000000000000000000000000000913 195.0
SHD1_k127_12839_6 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000003023 178.0
SHD1_k127_12839_7 - - - - 0.0000000000006958 75.0
SHD1_k127_12839_8 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000002528 64.0
SHD1_k127_1325236_0 (GGDEF) domain - - - 2.263e-211 685.0
SHD1_k127_1325236_1 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004417 372.0
SHD1_k127_1325236_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 299.0
SHD1_k127_1386842_0 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 596.0
SHD1_k127_1386842_1 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 581.0
SHD1_k127_1411611_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.0 1144.0
SHD1_k127_1411611_1 Aminotransferase class-III K01845 - 5.4.3.8 8.24e-261 805.0
SHD1_k127_1411611_10 LytTr DNA-binding domain K08083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 368.0
SHD1_k127_1411611_11 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 351.0
SHD1_k127_1411611_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 317.0
SHD1_k127_1411611_13 Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 298.0
SHD1_k127_1411611_14 Fimbrial assembly protein (PilN) K02663 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006012 267.0
SHD1_k127_1411611_15 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000001626 246.0
SHD1_k127_1411611_16 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000003119 237.0
SHD1_k127_1411611_17 Pilus assembly protein, PilP K02665 - - 0.000000000000000000000000000000000000000000000000000000000000003675 221.0
SHD1_k127_1411611_18 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000006198 171.0
SHD1_k127_1411611_2 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 1.642e-257 799.0
SHD1_k127_1411611_3 PFAM type II and III secretion system protein K02666 - - 3.163e-246 777.0
SHD1_k127_1411611_4 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.268e-244 761.0
SHD1_k127_1411611_5 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 3.313e-194 609.0
SHD1_k127_1411611_6 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 604.0
SHD1_k127_1411611_7 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 578.0
SHD1_k127_1411611_8 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 568.0
SHD1_k127_1411611_9 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 393.0
SHD1_k127_1421952_0 CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer K09952 - - 0.0 1268.0
SHD1_k127_1421952_1 RNB K01147 - 3.1.13.1 3.195e-309 958.0
SHD1_k127_1421952_10 SMART Calcium-binding EF-hand-containing protein - - - 0.00000000000000000000000000002788 125.0
SHD1_k127_1421952_11 Predicted membrane protein (DUF2238) K08984 - - 0.00000001472 55.0
SHD1_k127_1421952_13 Spore Coat Protein U domain - - - 0.00001012 54.0
SHD1_k127_1421952_2 Outer membrane usher protein K07347 - - 7.248e-230 736.0
SHD1_k127_1421952_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 574.0
SHD1_k127_1421952_4 TonB C terminal K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 377.0
SHD1_k127_1421952_5 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 310.0
SHD1_k127_1421952_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07661 - - 0.00000000000000000000000000000000000000000000000000000000000000000004626 240.0
SHD1_k127_1421952_7 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.00000000000000000000000000000000000000000000000000000000000000001582 232.0
SHD1_k127_1421952_8 Spore Coat Protein U domain - - - 0.000000000000000000000000000000001333 142.0
SHD1_k127_1421952_9 Cytochrome C oxidase, cbb3-type, subunit III K08738 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000001957 124.0
SHD1_k127_1424342_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01539 - 3.6.3.9 0.0 1180.0
SHD1_k127_1424342_1 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 1.265e-213 705.0
SHD1_k127_1424342_10 - - - - 0.000000000000000000000000000000000009051 138.0
SHD1_k127_1424342_11 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000003484 114.0
SHD1_k127_1424342_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 574.0
SHD1_k127_1424342_3 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 550.0
SHD1_k127_1424342_4 Transglycosylase SLT domain K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 396.0
SHD1_k127_1424342_5 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003944 310.0
SHD1_k127_1424342_6 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000000000000000000000000000001763 217.0
SHD1_k127_1424342_7 Smr domain - - - 0.00000000000000000000000000000000000000000000000000000000000007044 220.0
SHD1_k127_1424342_8 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000001846 206.0
SHD1_k127_1424342_9 NlpC/P60 family K19303 - - 0.0000000000000000000000000000000000000000000001991 171.0
SHD1_k127_1437248_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14392 - - 8.906e-251 778.0
SHD1_k127_1437248_1 TIGRFAM phosphate regulon sensor kinase PhoR K07636 - 2.7.13.3 3.845e-196 619.0
SHD1_k127_1437248_2 Two component transcriptional regulator PhoB, winged helix family K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 389.0
SHD1_k127_1437248_3 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007737 361.0
SHD1_k127_1447731_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0 1143.0
SHD1_k127_1447731_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 1.286e-250 780.0
SHD1_k127_1447731_10 of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 437.0
SHD1_k127_1447731_11 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 425.0
SHD1_k127_1447731_12 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 410.0
SHD1_k127_1447731_13 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 388.0
SHD1_k127_1447731_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 383.0
SHD1_k127_1447731_15 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 350.0
SHD1_k127_1447731_16 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 345.0
SHD1_k127_1447731_17 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 339.0
SHD1_k127_1447731_18 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 332.0
SHD1_k127_1447731_19 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 304.0
SHD1_k127_1447731_2 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 1.352e-247 768.0
SHD1_k127_1447731_20 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 286.0
SHD1_k127_1447731_21 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003164 242.0
SHD1_k127_1447731_22 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000001615 229.0
SHD1_k127_1447731_23 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000000000000000001405 212.0
SHD1_k127_1447731_24 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000000000000000000000004129 211.0
SHD1_k127_1447731_25 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000001225 124.0
SHD1_k127_1447731_26 transfer protein - - - 0.0000000000000000000000000000001657 139.0
SHD1_k127_1447731_27 ThiS family K03154 - - 0.00000000000000000000000205 103.0
SHD1_k127_1447731_28 Pfam:DUF1311 - - - 0.00000000000000000001865 98.0
SHD1_k127_1447731_3 Nitronate monooxygenase K00459 - 1.13.12.16 7.543e-240 744.0
SHD1_k127_1447731_30 helix_turn_helix, Lux Regulon - - - 0.0005003 45.0
SHD1_k127_1447731_4 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 3.425e-235 734.0
SHD1_k127_1447731_5 Involved in the biosynthesis of porphyrin-containing compound - - - 1.27e-206 649.0
SHD1_k127_1447731_6 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 463.0
SHD1_k127_1447731_7 Transporter associated domain K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 460.0
SHD1_k127_1447731_8 PFAM PhoH family protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 460.0
SHD1_k127_1447731_9 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 452.0
SHD1_k127_1455315_0 ATP synthase subunit D K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 307.0
SHD1_k127_1455315_1 transport system periplasmic component K01989 - - 0.000000000000000000000000000000000000000002211 169.0
SHD1_k127_1455315_2 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000002777 172.0
SHD1_k127_1455315_3 FecR protein - - - 0.000000000000000000000000000000001071 151.0
SHD1_k127_1455315_4 Hpt domain - - - 0.00000001516 67.0
SHD1_k127_146195_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1391.0
SHD1_k127_146195_1 TIGRFAM cytochrome c-type biogenesis protein CcmF K02198 - - 0.0 1099.0
SHD1_k127_146195_10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 353.0
SHD1_k127_146195_11 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 338.0
SHD1_k127_146195_12 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 325.0
SHD1_k127_146195_13 TIGRFAM periplasmic protein thiol disulphide oxidoreductase DsbE K02199 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 297.0
SHD1_k127_146195_14 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000000000000000004824 220.0
SHD1_k127_146195_15 Cytochrome C biogenesis protein K02200 - - 0.0000000000000000000000000000000000000000000000000000000000003333 214.0
SHD1_k127_146195_16 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000000000000000001347 152.0
SHD1_k127_146195_17 translation initiation factor activity - - - 0.000000000000007891 81.0
SHD1_k127_146195_18 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.00000000000001318 74.0
SHD1_k127_146195_2 SurA N-terminal domain K03770 - 5.2.1.8 3.605e-244 768.0
SHD1_k127_146195_20 - - - - 0.00002161 46.0
SHD1_k127_146195_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 2.2e-232 723.0
SHD1_k127_146195_4 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.708e-204 643.0
SHD1_k127_146195_5 PAC sensor-containing diguanylate cyclase phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 561.0
SHD1_k127_146195_6 TIGRFAM cytochrome c-type biogenesis protein CcmI K02200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 520.0
SHD1_k127_146195_7 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 457.0
SHD1_k127_146195_8 FIST_C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 456.0
SHD1_k127_146195_9 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 428.0
SHD1_k127_1469577_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1155.0
SHD1_k127_1469577_1 Polyphosphate kinase 2 (PPK2) - - - 3.191e-251 781.0
SHD1_k127_1469577_2 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 1.002e-239 745.0
SHD1_k127_1469577_3 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 394.0
SHD1_k127_1469577_4 Phosphoglycerate mutase family K08296 - - 0.0000000000000000000000000000000000000000000000001413 180.0
SHD1_k127_1469577_5 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000000000008101 161.0
SHD1_k127_1469577_6 Tautomerase enzyme K01821 - 5.3.2.6 0.000000000000000000000000000004725 119.0
SHD1_k127_1469577_7 - - - - 0.00000000000000000000001531 107.0
SHD1_k127_1487245_0 Histidine kinase - - - 2.28e-225 726.0
SHD1_k127_1487245_1 Major Facilitator - - - 2.82e-224 702.0
SHD1_k127_1487245_10 DsrE/DsrF-like family K06039 - - 0.000000000000000000000000000000000000000000002425 166.0
SHD1_k127_1487245_11 COG3038 Cytochrome B561 K12262 - - 0.0000000000000000000000000000000001542 134.0
SHD1_k127_1487245_12 cytochrome - - - 0.000000000000000000000000006367 114.0
SHD1_k127_1487245_2 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 579.0
SHD1_k127_1487245_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 414.0
SHD1_k127_1487245_4 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 392.0
SHD1_k127_1487245_5 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 372.0
SHD1_k127_1487245_6 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 326.0
SHD1_k127_1487245_7 glycosyl - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006146 256.0
SHD1_k127_1487245_8 glycosyl - - - 0.000000000000000000000000000000000000000000000000008854 185.0
SHD1_k127_1487245_9 diol metabolic process K01724 - 4.2.1.96 0.00000000000000000000000000000000000000000000008899 171.0
SHD1_k127_1500457_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 9.125e-208 667.0
SHD1_k127_1500457_1 PFAM aminotransferase class I and II K14267 - 2.6.1.17 1.824e-206 647.0
SHD1_k127_1500457_10 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000008232 143.0
SHD1_k127_1500457_2 PFAM type II secretion system protein E K02670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 577.0
SHD1_k127_1500457_3 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 560.0
SHD1_k127_1500457_4 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 505.0
SHD1_k127_1500457_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 357.0
SHD1_k127_1500457_6 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000005376 207.0
SHD1_k127_1500457_7 Bacterial-like globin K06886 - - 0.00000000000000000000000000000000000000000000000000000008261 197.0
SHD1_k127_1500457_8 ArsC family K00537 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000001485 194.0
SHD1_k127_1500457_9 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000009608 191.0
SHD1_k127_1512362_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 5.07e-312 969.0
SHD1_k127_1512362_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 9.107e-275 856.0
SHD1_k127_1512362_2 PFAM RNA-binding protein AU-1 Ribonuclease E G K08301 - - 2.806e-214 670.0
SHD1_k127_1512362_3 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 580.0
SHD1_k127_1512362_4 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000004281 224.0
SHD1_k127_1535487_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.023e-249 772.0
SHD1_k127_1535487_1 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 360.0
SHD1_k127_1535487_2 PFAM FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000003919 192.0
SHD1_k127_1556186_0 4 iron, 4 sulfur cluster binding - - - 3.725e-211 670.0
SHD1_k127_1556186_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.00000000000000000000000000000000000000000000000000003863 190.0
SHD1_k127_1560254_0 Mate efflux family protein K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 589.0
SHD1_k127_1560254_1 Short-chain dehydrogenase reductase (SDR) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 412.0
SHD1_k127_1560254_10 - - - - 0.0000000000000002072 83.0
SHD1_k127_1560254_11 - - - - 0.00000000003924 68.0
SHD1_k127_1560254_2 Oxygen tolerance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 387.0
SHD1_k127_1560254_5 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 318.0
SHD1_k127_1560254_6 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009536 318.0
SHD1_k127_1560254_8 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000001808 143.0
SHD1_k127_1560254_9 PFAM heat shock protein DnaJ domain protein - - - 0.000000000000000000000000000000023 130.0
SHD1_k127_158604_0 PFAM Cytochrome C K04561 - 1.7.2.5 3.215e-315 983.0
SHD1_k127_158604_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.336e-249 772.0
SHD1_k127_158604_10 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000001914 173.0
SHD1_k127_158604_11 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A - - - 0.0000000000000000000000000000000007559 134.0
SHD1_k127_158604_2 Soluble lytic murein transglycosylase L domain K08309 - - 1.905e-241 763.0
SHD1_k127_158604_3 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 4.602e-233 726.0
SHD1_k127_158604_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 534.0
SHD1_k127_158604_5 Lumazine binding domain K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 333.0
SHD1_k127_158604_6 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000158 291.0
SHD1_k127_158604_7 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000074 251.0
SHD1_k127_158604_8 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002649 244.0
SHD1_k127_158604_9 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000002349 224.0
SHD1_k127_1591549_0 PFAM Type II secretion system F domain K02653 - - 1.297e-198 625.0
SHD1_k127_1591549_1 Domain of unknown function DUF21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 610.0
SHD1_k127_1591549_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 577.0
SHD1_k127_1591549_3 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 545.0
SHD1_k127_1591549_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 317.0
SHD1_k127_1591549_5 PFAM AICARFT IMPCHase bienzyme formylation region K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000001746 156.0
SHD1_k127_1591549_6 Bacterial regulatory protein, Fis family K03557 - - 0.000000000000000000000000000000000003803 139.0
SHD1_k127_16245_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 1.334e-315 976.0
SHD1_k127_16245_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 7.527e-275 845.0
SHD1_k127_16245_10 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 376.0
SHD1_k127_16245_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009439 325.0
SHD1_k127_16245_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 292.0
SHD1_k127_16245_13 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 287.0
SHD1_k127_16245_14 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001115 269.0
SHD1_k127_16245_15 cyclic nucleotide binding K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000252 278.0
SHD1_k127_16245_16 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000171 267.0
SHD1_k127_16245_17 CRS1_YhbY K07574 - - 0.00000000000000000000000000000000000003735 149.0
SHD1_k127_16245_18 Preprotein translocase SecG subunit K03075 - - 0.0000000000000000000000000000000000009151 141.0
SHD1_k127_16245_19 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000002107 107.0
SHD1_k127_16245_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 5.279e-261 806.0
SHD1_k127_16245_3 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 9.778e-227 709.0
SHD1_k127_16245_4 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 522.0
SHD1_k127_16245_5 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 511.0
SHD1_k127_16245_6 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 486.0
SHD1_k127_16245_7 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 484.0
SHD1_k127_16245_8 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 456.0
SHD1_k127_16245_9 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 393.0
SHD1_k127_1678400_0 hydroxypyruvate reductase K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 603.0
SHD1_k127_1678400_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 282.0
SHD1_k127_1678400_2 EamA-like transporter family - - - 0.0000000000000000000000001505 109.0
SHD1_k127_1678400_3 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.000000000000002603 78.0
SHD1_k127_1708075_0 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 1.051e-202 634.0
SHD1_k127_1708075_1 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 338.0
SHD1_k127_1708075_2 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002141 240.0
SHD1_k127_1708075_3 TIGRFAM addiction module toxin, RelE StbE family K19092 - - 0.00000000000000000000000000000000000000006206 153.0
SHD1_k127_1708075_4 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.000000000000000000000000000000187 124.0
SHD1_k127_1730911_0 Beta-lactamase - - - 5.484e-298 922.0
SHD1_k127_1730911_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 535.0
SHD1_k127_1730911_10 domain protein - - - 0.0000000000000000000000000000000000001153 152.0
SHD1_k127_1730911_11 PFAM Ig domain protein group 1 domain protein - - - 0.00000000000000000000000000000000008451 149.0
SHD1_k127_1730911_12 Methyltransferase domain - - - 0.0000000000000000005264 89.0
SHD1_k127_1730911_2 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 499.0
SHD1_k127_1730911_3 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 333.0
SHD1_k127_1730911_4 Serine hydrolase involved in the detoxification of formaldehyde - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009719 258.0
SHD1_k127_1730911_5 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000002825 231.0
SHD1_k127_1730911_6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000000000000000000003432 226.0
SHD1_k127_1730911_7 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000000007039 207.0
SHD1_k127_1730911_8 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000000000006862 146.0
SHD1_k127_1730911_9 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K03286,K12976,K16079 - - 0.00000000000000000000000000000000000003275 151.0
SHD1_k127_1753392_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 1.025e-260 808.0
SHD1_k127_1753392_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 596.0
SHD1_k127_1753392_2 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 527.0
SHD1_k127_1753392_3 PFAM Adenylyl cyclase class-3 4 guanylyl cyclase K01769 - 4.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009758 384.0
SHD1_k127_1753392_4 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000004007 249.0
SHD1_k127_1753392_5 Zinc-finger domain - - - 0.00000000000000000000004013 99.0
SHD1_k127_1769587_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1873.0
SHD1_k127_1769587_1 Fumarate reductase flavoprotein C-term K00394 - 1.8.99.2 0.0 1289.0
SHD1_k127_1769587_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 4.311e-212 663.0
SHD1_k127_1769587_11 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 581.0
SHD1_k127_1769587_12 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 583.0
SHD1_k127_1769587_13 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 570.0
SHD1_k127_1769587_14 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 547.0
SHD1_k127_1769587_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 516.0
SHD1_k127_1769587_16 4Fe-4S binding domain K21308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 489.0
SHD1_k127_1769587_17 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 471.0
SHD1_k127_1769587_18 DMSO reductase anchor subunit (DmsC) K21309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 468.0
SHD1_k127_1769587_19 PFAM MoeA domain protein domain I and II K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 462.0
SHD1_k127_1769587_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0 1106.0
SHD1_k127_1769587_20 KAP family P-loop domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 428.0
SHD1_k127_1769587_21 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009565 411.0
SHD1_k127_1769587_22 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 408.0
SHD1_k127_1769587_23 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 399.0
SHD1_k127_1769587_24 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 383.0
SHD1_k127_1769587_25 Glycosyl transferase - GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 381.0
SHD1_k127_1769587_26 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 369.0
SHD1_k127_1769587_27 Adenosine-5'-phosphosulfate reductase beta subunit K00395 - 1.8.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 347.0
SHD1_k127_1769587_28 Nitrate reductase gamma subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 349.0
SHD1_k127_1769587_29 Histidine kinase K07673 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 317.0
SHD1_k127_1769587_3 Cysteine-rich domain - - - 1.932e-289 893.0
SHD1_k127_1769587_30 helix_turn_helix, Lux Regulon K07684 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 293.0
SHD1_k127_1769587_31 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004734 274.0
SHD1_k127_1769587_32 Histidine triad (Hit) protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001726 271.0
SHD1_k127_1769587_33 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000001941 267.0
SHD1_k127_1769587_34 rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000137 259.0
SHD1_k127_1769587_35 Domain of unknown function (DUF4279) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001146 251.0
SHD1_k127_1769587_36 Sulfurtransferase TusA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001836 244.0
SHD1_k127_1769587_37 PFAM UspA domain protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000003808 244.0
SHD1_k127_1769587_38 DsrE/DsrF-like family K07235 - - 0.0000000000000000000000000000000000000000000000000000000000000000606 223.0
SHD1_k127_1769587_39 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007452 227.0
SHD1_k127_1769587_4 Nitrite and sulphite reductase 4Fe-4S domain K11180 - 1.8.99.5 1.76e-271 836.0
SHD1_k127_1769587_40 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000005522 224.0
SHD1_k127_1769587_41 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000000000000000000168 209.0
SHD1_k127_1769587_42 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000000000000000000000000000000000000000000000000329 212.0
SHD1_k127_1769587_43 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000000000000000000001949 203.0
SHD1_k127_1769587_44 DsrE/DsrF-like family K07236 - - 0.0000000000000000000000000000000000000000000000000000000003713 204.0
SHD1_k127_1769587_45 Cas6 Crispr - - - 0.0000000000000000000000000000000000000000000000000000000005672 207.0
SHD1_k127_1769587_46 molybdopterin biosynthesis MoaE K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000003317 195.0
SHD1_k127_1769587_47 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000000000000004208 185.0
SHD1_k127_1769587_48 - - - - 0.00000000000000000000000000000000000000000005493 166.0
SHD1_k127_1769587_49 DsrH like protein K07237 - - 0.00000000000000000000000000000000000001547 146.0
SHD1_k127_1769587_5 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 2.359e-251 785.0
SHD1_k127_1769587_50 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000008171 142.0
SHD1_k127_1769587_51 PFAM Uncharacterised conserved protein UCP030820 - - - 0.00000000000000000000000000000000001305 142.0
SHD1_k127_1769587_53 DsrC like protein K11179 - - 0.00000000000000000000000000000003915 131.0
SHD1_k127_1769587_54 Sulfurtransferase TusA K04085 - - 0.0000000000000000000000000000002497 124.0
SHD1_k127_1769587_55 Protein conserved in bacteria K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000001801 123.0
SHD1_k127_1769587_56 - - - - 0.0000000000000000000000000006875 123.0
SHD1_k127_1769587_57 - - - - 0.000000000000000000000000003587 115.0
SHD1_k127_1769587_58 - - - - 0.0000000000000000000000004184 106.0
SHD1_k127_1769587_59 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000000000000000000528 103.0
SHD1_k127_1769587_6 Nitrite and sulphite reductase 4Fe-4S domain K11181 - 1.8.99.5 4.311e-242 747.0
SHD1_k127_1769587_60 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000001889 81.0
SHD1_k127_1769587_61 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000001629 64.0
SHD1_k127_1769587_62 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000009374 59.0
SHD1_k127_1769587_63 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000001731 55.0
SHD1_k127_1769587_64 TIGRFAM sulfur relay protein, TusE DsrC DsvC family K11179 - - 0.000002219 50.0
SHD1_k127_1769587_65 Glucose inhibited division protein A K03388,K16885 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0001273 45.0
SHD1_k127_1769587_7 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 1.162e-227 708.0
SHD1_k127_1769587_8 AAA domain K02224 - 6.3.5.11,6.3.5.9 1.742e-227 713.0
SHD1_k127_1769587_9 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 1.301e-213 669.0
SHD1_k127_179333_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.479e-300 925.0
SHD1_k127_179333_1 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 1.905e-275 850.0
SHD1_k127_179333_10 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000008163 237.0
SHD1_k127_179333_11 E-Z type HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000002092 225.0
SHD1_k127_179333_12 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000007136 156.0
SHD1_k127_179333_13 - - - - 0.000000000000000000000000000000000000621 149.0
SHD1_k127_179333_15 TfoX N-terminal domain K07343 - - 0.00006946 49.0
SHD1_k127_179333_2 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 2.805e-249 781.0
SHD1_k127_179333_3 NADH flavin oxidoreductase NADH oxidase K10680 - - 9.912e-194 610.0
SHD1_k127_179333_4 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 587.0
SHD1_k127_179333_5 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 507.0
SHD1_k127_179333_6 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007087 454.0
SHD1_k127_179333_7 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 404.0
SHD1_k127_179333_8 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 396.0
SHD1_k127_179333_9 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000004282 231.0
SHD1_k127_1845484_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.501e-198 621.0
SHD1_k127_1845484_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001987 261.0
SHD1_k127_1845484_2 Belongs to the UPF0235 family K09131 - - 0.00000000000000000000000000000000000000000006548 166.0
SHD1_k127_1845484_3 Putative quorum-sensing-regulated virulence factor K09954 - - 0.00000000000000000000000000000000001504 136.0
SHD1_k127_1845484_4 Putative quorum-sensing-regulated virulence factor K09954 - - 0.000000000000000000000000000000002827 131.0
SHD1_k127_1845484_5 Putative quorum-sensing-regulated virulence factor K09954 - - 0.00003934 46.0
SHD1_k127_1845484_6 Protein of unknown function (DUF3617) - - - 0.0001528 53.0
SHD1_k127_187946_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169,K03737 - 1.2.7.1 6.26e-232 723.0
SHD1_k127_187946_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 381.0
SHD1_k127_187946_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172,K18357 - 1.2.1.58,1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 287.0
SHD1_k127_187946_3 DSBA-like thioredoxin domain K03673 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006143 252.0
SHD1_k127_187946_4 Sporulation related domain - - - 0.0000000000000000000000000000000001999 142.0
SHD1_k127_187946_5 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.000000000000000000000000000000005989 128.0
SHD1_k127_1938814_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007595 535.0
SHD1_k127_1938814_1 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 486.0
SHD1_k127_1938814_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 426.0
SHD1_k127_1938814_3 PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase 1 K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 426.0
SHD1_k127_1938814_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 380.0
SHD1_k127_1938814_5 Acyl carrier protein phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002525 263.0
SHD1_k127_1938814_6 LPP20 lipoprotein - - - 0.00000000000000000000000000000000000000000005414 166.0
SHD1_k127_1938814_7 Membrane protein implicated in regulation of membrane protease activity - - - 0.0000000000000000000000000000000008301 146.0
SHD1_k127_1938814_8 - - - - 0.000000000001084 80.0
SHD1_k127_1938814_9 FecR protein - - - 0.00000000000807 75.0
SHD1_k127_1949803_0 ABC transporter transmembrane region K11004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 598.0
SHD1_k127_1949803_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 520.0
SHD1_k127_1949803_10 PIN domain K07063 - - 0.000000000000000000000001456 109.0
SHD1_k127_1949803_11 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.0000000000000000577 82.0
SHD1_k127_1949803_12 Lysozyme inhibitor LprI - - - 0.000000000000007102 87.0
SHD1_k127_1949803_2 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006733 379.0
SHD1_k127_1949803_3 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 313.0
SHD1_k127_1949803_4 Transposase IS200 like K07491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001183 274.0
SHD1_k127_1949803_5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004007 268.0
SHD1_k127_1949803_6 PFAM PEGA domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004207 258.0
SHD1_k127_1949803_7 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000005555 179.0
SHD1_k127_1949803_8 Chemoreceptor zinc-binding domain - - - 0.0000000000000000000000000000000000000000000009311 169.0
SHD1_k127_1949803_9 Iron-binding zinc finger CDGSH type - - - 0.0000000000000000000000001827 106.0
SHD1_k127_195590_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 5.398e-280 864.0
SHD1_k127_195590_1 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 5.884e-262 822.0
SHD1_k127_195590_10 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000000000000000001029 221.0
SHD1_k127_195590_11 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000000000000000000000000000000000000002047 178.0
SHD1_k127_195590_12 PFAM CutA1 divalent ion tolerance protein K03926 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000003228 154.0
SHD1_k127_195590_2 The glycine cleavage system catalyzes the degradation of glycine K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 2.906e-219 683.0
SHD1_k127_195590_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 515.0
SHD1_k127_195590_4 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 499.0
SHD1_k127_195590_5 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 416.0
SHD1_k127_195590_6 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009088 277.0
SHD1_k127_195590_7 Protein of unknown function (DUF3426) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003842 237.0
SHD1_k127_195590_8 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000002603 229.0
SHD1_k127_195590_9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000000000000000000001039 227.0
SHD1_k127_1996997_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K18138 - - 0.0 1594.0
SHD1_k127_1996997_1 Ring hydroxylating alpha subunit (catalytic domain) K00499 - 1.14.15.7 1.096e-216 676.0
SHD1_k127_1996997_10 - - - - 0.000000000000000000000000000000000000000000000000002482 188.0
SHD1_k127_1996997_11 Transcriptional regulator K07782,K15852,K19666,K19734 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000000000000000000000000000000000000000000000004948 189.0
SHD1_k127_1996997_12 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000007235 185.0
SHD1_k127_1996997_13 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000000000002222 109.0
SHD1_k127_1996997_2 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 608.0
SHD1_k127_1996997_3 Polyprenyl synthetase K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 477.0
SHD1_k127_1996997_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 480.0
SHD1_k127_1996997_5 EamA-like transporter family K15270 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 390.0
SHD1_k127_1996997_6 MltA-interacting MipA family protein K07274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 340.0
SHD1_k127_1996997_7 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000000000000000000000000000000000000000000000000000002429 215.0
SHD1_k127_1996997_8 SpoIIAA-like - - - 0.000000000000000000000000000000000000000000000000000001142 193.0
SHD1_k127_1996997_9 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000004803 196.0
SHD1_k127_200837_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 4.64e-283 873.0
SHD1_k127_200837_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.056e-251 779.0
SHD1_k127_200837_10 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 284.0
SHD1_k127_200837_11 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A K02876 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008671 246.0
SHD1_k127_200837_12 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004256 244.0
SHD1_k127_200837_13 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002174 239.0
SHD1_k127_200837_14 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000000000418 230.0
SHD1_k127_200837_15 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000001064 229.0
SHD1_k127_200837_16 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000001284 229.0
SHD1_k127_200837_17 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000000000001394 210.0
SHD1_k127_200837_18 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000004352 202.0
SHD1_k127_200837_19 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000004554 194.0
SHD1_k127_200837_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 539.0
SHD1_k127_200837_20 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000009198 190.0
SHD1_k127_200837_21 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000000000000000004669 184.0
SHD1_k127_200837_22 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000000000000000000000000000002751 183.0
SHD1_k127_200837_23 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000006511 178.0
SHD1_k127_200837_24 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000000000002399 162.0
SHD1_k127_200837_25 - - - - 0.000000000000000000000000000000000000000005879 157.0
SHD1_k127_200837_26 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000000006683 149.0
SHD1_k127_200837_27 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000000222 141.0
SHD1_k127_200837_28 - - - - 0.0000000000000000000000000000005715 126.0
SHD1_k127_200837_29 Ribosomal protein L30p/L7e K02907 - - 0.0000000000000000000000000003104 113.0
SHD1_k127_200837_3 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 511.0
SHD1_k127_200837_30 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000002048 86.0
SHD1_k127_200837_31 elongation factor Tu K02358 - - 0.00000000000000001111 82.0
SHD1_k127_200837_32 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000006426 74.0
SHD1_k127_200837_4 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 416.0
SHD1_k127_200837_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008485 374.0
SHD1_k127_200837_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 362.0
SHD1_k127_200837_7 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 361.0
SHD1_k127_200837_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 340.0
SHD1_k127_200837_9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 310.0
SHD1_k127_2087284_0 DEAD DEAH box helicase domain protein K03654 - 3.6.4.12 0.0 1098.0
SHD1_k127_2087284_1 Enoyl-CoA hydratase/isomerase K07516 - 1.1.1.35 9.453e-289 893.0
SHD1_k127_2087284_10 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.000000000000000000000000000000000000000000000000000000000005198 211.0
SHD1_k127_2087284_11 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000000000000000000008994 208.0
SHD1_k127_2087284_12 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000000000000000000000000000002911 201.0
SHD1_k127_2087284_13 - - - - 0.000000000000000000000000000000000000000000000000002245 189.0
SHD1_k127_2087284_14 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000000000000123 181.0
SHD1_k127_2087284_15 Uncharacterized ACR, COG1993 - - - 0.00000000000000000000000000000000001185 138.0
SHD1_k127_2087284_16 Chalcone isomerase-like - - - 0.00000000000000000000000006286 111.0
SHD1_k127_2087284_17 pathogenesis - - - 0.000000000000000000005694 101.0
SHD1_k127_2087284_18 - - - - 0.000000000000000000078 99.0
SHD1_k127_2087284_19 nucleotidyltransferase domain K07075 - - 0.000000000000001781 79.0
SHD1_k127_2087284_2 Thiolase, C-terminal domain K00632 - 2.3.1.16 1.095e-225 703.0
SHD1_k127_2087284_20 Chalcone isomerase-like - - - 0.000000003667 59.0
SHD1_k127_2087284_3 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 497.0
SHD1_k127_2087284_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 433.0
SHD1_k127_2087284_5 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 435.0
SHD1_k127_2087284_6 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 346.0
SHD1_k127_2087284_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 332.0
SHD1_k127_2087284_8 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 329.0
SHD1_k127_2093890_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 4.16e-321 995.0
SHD1_k127_2093890_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 1.162e-208 651.0
SHD1_k127_2093890_2 Sulfate permease family K03321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 289.0
SHD1_k127_2093890_3 Transcriptional regulator, Crp Fnr family - - - 0.0000598 46.0
SHD1_k127_2127684_0 Transposase DDE domain group 1 - - - 1.32e-197 626.0
SHD1_k127_2127684_1 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 518.0
SHD1_k127_2127684_2 Psort location Cytoplasmic, score - - - 0.0004605 44.0
SHD1_k127_2161902_0 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 345.0
SHD1_k127_2161902_1 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 304.0
SHD1_k127_2161902_2 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001046 280.0
SHD1_k127_2161902_3 Plasmid stabilization system - - - 0.0000000000000000000009722 98.0
SHD1_k127_2161902_4 Plasmid stabilization system - - - 0.00000006845 58.0
SHD1_k127_2161902_5 Carbohydrate kinase - - - 0.0000001996 56.0
SHD1_k127_2161902_6 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.000001046 54.0
SHD1_k127_2174873_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 7.57e-282 878.0
SHD1_k127_2174873_1 K+ potassium transporter K03549 - - 2.071e-257 807.0
SHD1_k127_2174873_10 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 334.0
SHD1_k127_2174873_11 ABC 3 transport family K02075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 327.0
SHD1_k127_2174873_12 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008851 331.0
SHD1_k127_2174873_13 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001656 289.0
SHD1_k127_2174873_14 PFAM response regulator receiver K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002487 280.0
SHD1_k127_2174873_15 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000411 261.0
SHD1_k127_2174873_16 TIGRFAM CRISPR-associated protein K19118 - - 0.0000000000000000000000000000000001641 136.0
SHD1_k127_2174873_17 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000003107 128.0
SHD1_k127_2174873_18 nucleotidyltransferase activity K07076 - - 0.000000000000000000000001825 107.0
SHD1_k127_2174873_19 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000007115 102.0
SHD1_k127_2174873_2 von Willebrand factor, type A - - - 5.286e-202 646.0
SHD1_k127_2174873_20 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000000000000000000004719 101.0
SHD1_k127_2174873_21 - - - - 0.00000007755 59.0
SHD1_k127_2174873_22 HEPN domain - - - 0.00000133 54.0
SHD1_k127_2174873_3 phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 584.0
SHD1_k127_2174873_4 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 493.0
SHD1_k127_2174873_5 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 492.0
SHD1_k127_2174873_6 geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 447.0
SHD1_k127_2174873_7 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 425.0
SHD1_k127_2174873_8 Zinc-uptake complex component A periplasmic K02077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006888 420.0
SHD1_k127_2174873_9 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 372.0
SHD1_k127_2196260_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 3.465e-203 640.0
SHD1_k127_2196260_1 Sulfate permease family K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005909 535.0
SHD1_k127_2196260_10 Transposase IS200 like - - - 0.00000000152 60.0
SHD1_k127_2196260_2 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 406.0
SHD1_k127_2196260_3 PFAM Integrase catalytic region K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 352.0
SHD1_k127_2196260_4 Transposase K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 326.0
SHD1_k127_2196260_5 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 302.0
SHD1_k127_2196260_6 Transposase K07483 - - 0.000000000000000000000000002632 115.0
SHD1_k127_2196260_7 - - - - 0.000000000000000000000000006404 112.0
SHD1_k127_2196260_8 ERAD pathway K17535 - 2.7.11.1 0.000000000000000000000006052 116.0
SHD1_k127_2196260_9 Transposase IS200 like - - - 0.00000000000000000001628 92.0
SHD1_k127_2213495_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 4.018e-258 797.0
SHD1_k127_2213495_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 563.0
SHD1_k127_2213495_2 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645,K13935,K15355 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 534.0
SHD1_k127_2213495_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 498.0
SHD1_k127_2213495_4 KR domain K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 408.0
SHD1_k127_2213495_5 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000000000001138 153.0
SHD1_k127_2213495_6 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000001227 139.0
SHD1_k127_2213495_7 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000000000002585 117.0
SHD1_k127_2213495_8 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000006123 56.0
SHD1_k127_221554_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1382.0
SHD1_k127_221554_1 SMART adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 538.0
SHD1_k127_221554_2 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 413.0
SHD1_k127_221554_3 Phosphoglycolate phosphatase K22292 - 3.1.3.105 0.0000000000000000000000000000000000000000000000000000000000000000007335 234.0
SHD1_k127_221554_4 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000002451 124.0
SHD1_k127_221554_5 TIGRFAM PAS sensor protein - - - 0.00000000000000000007947 104.0
SHD1_k127_221554_6 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000008324 79.0
SHD1_k127_2217656_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 539.0
SHD1_k127_2217656_1 histidine kinase HAMP region domain protein K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 362.0
SHD1_k127_2217656_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 322.0
SHD1_k127_2217656_3 PFAM response regulator receiver K02483 - - 0.0000000000000000000000000000000000000000000001599 170.0
SHD1_k127_2223321_0 Pfam Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 556.0
SHD1_k127_2223321_1 Glutathione S-transferase, C-terminal domain K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 365.0
SHD1_k127_2223321_2 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 294.0
SHD1_k127_2223321_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008424 264.0
SHD1_k127_2223321_4 Stringent starvation protein B K03600 - - 0.0000000000000000000000000000000000000000000000002523 181.0
SHD1_k127_2223321_5 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000117 137.0
SHD1_k127_2223321_6 - - - - 0.000000000000001145 78.0
SHD1_k127_2231425_0 glutamine synthetase K01915 - 6.3.1.2 3.188e-288 887.0
SHD1_k127_2231425_1 Nitrogen metabolism transcriptional regulator, NtrC, Fis Family K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 1.296e-253 794.0
SHD1_k127_2231425_2 SMART ATP-binding region ATPase domain protein K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 542.0
SHD1_k127_2231425_3 chlorophyll binding K02690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 517.0
SHD1_k127_2231425_4 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 287.0
SHD1_k127_2231425_5 Prokaryotic cytochrome b561 K12262 - - 0.00000000000000000000000000000000000000000000000000000000009767 205.0
SHD1_k127_2231425_6 Domain of unknown function (DUF4124) - - - 0.00000000000000000000000000001981 124.0
SHD1_k127_2258531_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 6.701e-220 688.0
SHD1_k127_2258531_1 Nif-specific regulatory protein K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 574.0
SHD1_k127_2258531_2 Iron-sulfur cluster assembly enzyme K22068 - - 0.000000000000000000000000000000000000000000000000000000000000002123 220.0
SHD1_k127_2258951_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 5.302e-233 723.0
SHD1_k127_2258951_1 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 590.0
SHD1_k127_2258951_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 481.0
SHD1_k127_2258951_3 PFAM Peptidase S24 S26A S26B, conserved region K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 421.0
SHD1_k127_2258951_4 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003653 419.0
SHD1_k127_2258951_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 387.0
SHD1_k127_2258951_6 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 334.0
SHD1_k127_2258951_7 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000002923 153.0
SHD1_k127_2258951_8 NMT1-like family K02051 - - 0.00000000000000000004561 100.0
SHD1_k127_2267896_0 Histidine kinase - - - 0.0 1354.0
SHD1_k127_2267896_1 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 575.0
SHD1_k127_2267896_2 Divalent cation transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002392 269.0
SHD1_k127_2267896_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000001218 207.0
SHD1_k127_2267896_4 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000001809 205.0
SHD1_k127_2267896_5 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000000005084 68.0
SHD1_k127_23044_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 544.0
SHD1_k127_23044_1 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 554.0
SHD1_k127_23044_2 Signal transduction response regulator, receiver region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 405.0
SHD1_k127_23044_3 PFAM TonB-dependent receptor plug K02014,K16089 - - 0.00000000000000000000000000000000000000002582 154.0
SHD1_k127_23044_4 Domain of unknown function (DUF4154) - - - 0.0000000000000000000000000000000000000006072 154.0
SHD1_k127_2321012_0 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 601.0
SHD1_k127_2321012_1 GGDEF EAL family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 385.0
SHD1_k127_2321012_2 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000002086 211.0
SHD1_k127_2321012_3 - - - - 0.0000000000000000000000000000000000000000000000000003394 184.0
SHD1_k127_2321012_4 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000001947 184.0
SHD1_k127_23434_0 Histidine Phosphotransfer domain K02487,K06596 - - 0.0 1716.0
SHD1_k127_23434_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1386.0
SHD1_k127_23434_10 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 314.0
SHD1_k127_23434_11 Phytochelatin synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002649 292.0
SHD1_k127_23434_12 Protein of unknown function (DUF3037) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001927 247.0
SHD1_k127_23434_13 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000517 235.0
SHD1_k127_23434_14 cheY-homologous receiver domain K02657 - - 0.000000000000000000000000000000000000000000000000000000000000001007 220.0
SHD1_k127_23434_15 Two component signalling adaptor domain K02659 - - 0.0000000000000000000000000000000000000000000000000000000000005469 214.0
SHD1_k127_23434_16 cheY-homologous receiver domain K02658 - - 0.00000000000000000000000000000000000000000000000000000003712 199.0
SHD1_k127_23434_17 PFAM peptidase M3A and M3B thimet oligopeptidase F K01414 - 3.4.24.70 0.0000000000000000000000000000000000000000000000000000001586 196.0
SHD1_k127_23434_18 peptidase - - - 0.0000000000000000000000000000000000000001983 153.0
SHD1_k127_23434_19 - - - - 0.0000000000000000000000000000000002521 141.0
SHD1_k127_23434_2 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1243.0
SHD1_k127_23434_20 YCII-related domain K09780 - - 0.0000000000000000000000008377 106.0
SHD1_k127_23434_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 6.696e-259 806.0
SHD1_k127_23434_4 Amidohydrolase family K01465 - 3.5.2.3 1.682e-250 780.0
SHD1_k127_23434_5 PFAM TrkA-N domain protein K03499 - - 3.137e-245 762.0
SHD1_k127_23434_6 histidine kinase HAMP region domain protein K02660,K03406 - - 4.433e-203 652.0
SHD1_k127_23434_7 PFAM aspartate ornithine carbamoyltransferase Asp Orn-binding region K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 578.0
SHD1_k127_23434_8 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 350.0
SHD1_k127_23434_9 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 341.0
SHD1_k127_2351578_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 1.255e-304 943.0
SHD1_k127_2351578_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 6.117e-238 738.0
SHD1_k127_2351578_10 Transcriptional regulator K13643 - - 0.000000000000000000000000000000000000000000000000000000000004152 211.0
SHD1_k127_2351578_11 TIGRFAM iron-sulfur cluster assembly protein IscA K13628 - - 0.000000000000000000000000000000000000000000000000000000008458 198.0
SHD1_k127_2351578_12 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.0000000000000000000000000000000000000000000000000000001415 196.0
SHD1_k127_2351578_13 PFAM HPP family protein K07168 - - 0.000000000000000000000000000000000000000000000005114 182.0
SHD1_k127_2351578_14 geranylgeranyl reductase activity K10960,K17830 - 1.3.1.101,1.3.1.111,1.3.1.83,1.3.7.11 0.00000000000000000000000000000000000000000000001727 186.0
SHD1_k127_2351578_15 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000005552 138.0
SHD1_k127_2351578_16 Iron-sulphur cluster assembly - - - 0.00000000000000000000000000002861 117.0
SHD1_k127_2351578_17 Protein of unknown function (DUF2971) - - - 0.0000000000006652 74.0
SHD1_k127_2351578_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 466.0
SHD1_k127_2351578_3 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 421.0
SHD1_k127_2351578_4 Protein of unknown function (DUF3050) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 359.0
SHD1_k127_2351578_5 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 325.0
SHD1_k127_2351578_6 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003452 278.0
SHD1_k127_2351578_7 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000212 252.0
SHD1_k127_2351578_8 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000000002143 237.0
SHD1_k127_2351578_9 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000000000000000000000000000008462 238.0
SHD1_k127_2355080_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1282.0
SHD1_k127_2355080_1 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 326.0
SHD1_k127_2355080_2 Thioredoxin K05838 - - 0.00000000000000000000000000000000000000000000000000000003949 198.0
SHD1_k127_2355080_3 Tautomerase enzyme - - - 0.0000000000000000000000000000000004973 132.0
SHD1_k127_2355080_4 - - - - 0.0000000002409 65.0
SHD1_k127_2377770_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 3.165e-237 737.0
SHD1_k127_2377770_1 PFAM glycosyl transferase family 39 - - - 3.293e-210 667.0
SHD1_k127_2377770_2 BNR repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 510.0
SHD1_k127_2377770_3 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 468.0
SHD1_k127_2377770_4 dTDP-glucose 4-6-dehydratase K01710,K01784 - 4.2.1.46,5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 318.0
SHD1_k127_2377770_5 - - - - 0.000000003186 63.0
SHD1_k127_238126_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 481.0
SHD1_k127_238126_3 LPP20 lipoprotein - - - 0.0000000000006261 70.0
SHD1_k127_2409772_0 PFAM aminotransferase class IV K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 471.0
SHD1_k127_2409772_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 321.0
SHD1_k127_2409772_2 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 291.0
SHD1_k127_2409772_3 Belongs to the UPF0250 family K09158 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000001351 79.0
SHD1_k127_2416162_0 Belongs to the peptidase M16 family K07263 - - 2.566e-210 661.0
SHD1_k127_2416162_1 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 572.0
SHD1_k127_2416162_10 PFAM Sulfate transporter antisigma-factor antagonist STAS K17763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008786 372.0
SHD1_k127_2416162_11 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 363.0
SHD1_k127_2416162_12 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 349.0
SHD1_k127_2416162_13 protein conserved in bacteria K09859 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 338.0
SHD1_k127_2416162_14 Haemolysin-III related K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 319.0
SHD1_k127_2416162_15 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003479 270.0
SHD1_k127_2416162_16 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002129 268.0
SHD1_k127_2416162_17 Peptidoglycan-synthase activator LpoB K07337 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007533 250.0
SHD1_k127_2416162_18 Protein of unknown function (DUF815) K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008694 250.0
SHD1_k127_2416162_19 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000001305 171.0
SHD1_k127_2416162_2 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 553.0
SHD1_k127_2416162_20 - K17762 - - 0.00000000000000000000000000000000000000000003436 164.0
SHD1_k127_2416162_21 LPP20 lipoprotein - - - 0.0000000000000000000000000000000004852 139.0
SHD1_k127_2416162_22 dUTPase - - - 0.00000000000000000000000000000000545 139.0
SHD1_k127_2416162_23 LPP20 lipoprotein - - - 0.000000000000000000000000000648 126.0
SHD1_k127_2416162_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007617 506.0
SHD1_k127_2416162_4 anti-sigma regulatory factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 448.0
SHD1_k127_2416162_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 426.0
SHD1_k127_2416162_6 Sigma-70 factor, region 1.2 K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 415.0
SHD1_k127_2416162_7 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 386.0
SHD1_k127_2416162_8 TIGRFAM cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 372.0
SHD1_k127_2416162_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 372.0
SHD1_k127_2418545_0 fibronectin type III domain protein K06882 - - 0.0 1309.0
SHD1_k127_2418545_1 CHASE2 K01768 - 4.6.1.1 7.374e-302 935.0
SHD1_k127_2418545_2 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 2.669e-289 903.0
SHD1_k127_2418545_3 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008678 488.0
SHD1_k127_2418545_4 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 297.0
SHD1_k127_2418545_5 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002719 253.0
SHD1_k127_2418545_6 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000002549 241.0
SHD1_k127_2418545_7 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000234 155.0
SHD1_k127_2418545_8 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000001558 122.0
SHD1_k127_2511197_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0 1100.0
SHD1_k127_2511197_1 DSBA Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 325.0
SHD1_k127_2511197_2 PFAM glycine cleavage T protein (aminomethyl transferase) K06980 - - 0.00003012 50.0
SHD1_k127_2556220_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 2045.0
SHD1_k127_2556220_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1175.0
SHD1_k127_2556220_10 PFAM Sporulation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001373 216.0
SHD1_k127_2556220_11 Phosphopantetheine attachment site K02078 - - 0.0000000000000000000000000000000966 125.0
SHD1_k127_2556220_12 - - - - 0.00000000000000000000000000008063 117.0
SHD1_k127_2556220_13 translation initiation factor activity - - - 0.00000000000000000000000001499 111.0
SHD1_k127_2556220_2 Beta-ketoacyl synthase, C-terminal domain K09458,K14660 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 6.91e-204 641.0
SHD1_k127_2556220_3 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009838 571.0
SHD1_k127_2556220_4 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 507.0
SHD1_k127_2556220_5 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 410.0
SHD1_k127_2556220_6 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 397.0
SHD1_k127_2556220_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 349.0
SHD1_k127_2556220_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 294.0
SHD1_k127_2556220_9 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001742 247.0
SHD1_k127_2564840_0 PFAM tRNA synthetase class II (D K and N) K04567 - 6.1.1.6 9.961e-281 868.0
SHD1_k127_2564840_1 SMC domain protein - - - 6.331e-253 784.0
SHD1_k127_2564840_10 - - - - 0.00000000000000000000000006134 110.0
SHD1_k127_2564840_2 Outer membrane lipoprotein-sorting protein K07003 - - 7.005e-235 749.0
SHD1_k127_2564840_3 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 310.0
SHD1_k127_2564840_4 Protein of unknown function C-terminus (DUF2399) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003505 267.0
SHD1_k127_2564840_5 Outer membrane lipoprotein-sorting protein K07003 - - 0.00000000000000000000000000000000000000000000000000000000000005066 226.0
SHD1_k127_2564840_6 Sh3 type 3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000006348 223.0
SHD1_k127_2564840_7 - - - - 0.000000000000000000000000000000000000000000000000000000003202 204.0
SHD1_k127_2564840_8 transcriptional regulator K16137 - - 0.0000000000000000000000000000000000000000000003734 173.0
SHD1_k127_2564840_9 Domain of unknown function (DUF4260) - - - 0.00000000000000000000000000000000000000000002342 168.0
SHD1_k127_2757590_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0 1015.0
SHD1_k127_2757590_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 8.445e-264 817.0
SHD1_k127_2757590_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 2.707e-208 650.0
SHD1_k127_2757590_3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 5.817e-200 627.0
SHD1_k127_2757590_4 Nucleoside H+ symporter K05820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007724 463.0
SHD1_k127_2757590_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 416.0
SHD1_k127_2757590_6 PFAM regulatory protein AsnC Lrp family K03719 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 280.0
SHD1_k127_2757590_7 pilus assembly protein FimV K08086 - - 0.00000000000000000000000000000000000000000000000000000000000006898 224.0
SHD1_k127_2757590_8 - - - - 0.00000000001145 68.0
SHD1_k127_2761310_0 PFAM peptidase M3A and M3B thimet oligopeptidase F K01414 - 3.4.24.70 4.368e-265 823.0
SHD1_k127_2761310_1 PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 342.0
SHD1_k127_2761310_2 Pfam Glutaredoxin - - - 0.000000000000000000000000000000000000005149 151.0
SHD1_k127_2788056_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.62e-279 867.0
SHD1_k127_2788056_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 8.811e-243 760.0
SHD1_k127_2788056_10 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 424.0
SHD1_k127_2788056_11 Belongs to the pseudouridine synthase RsuA family K06183 - 5.4.99.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003953 422.0
SHD1_k127_2788056_12 MucB/RseB C-terminal domain K03598 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 390.0
SHD1_k127_2788056_13 TIGRFAM RNA polymerase sigma factor RpoE K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 358.0
SHD1_k127_2788056_14 PFAM nitroreductase K09019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 338.0
SHD1_k127_2788056_15 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 339.0
SHD1_k127_2788056_16 YaeQ - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 329.0
SHD1_k127_2788056_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 332.0
SHD1_k127_2788056_18 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 332.0
SHD1_k127_2788056_19 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003582 286.0
SHD1_k127_2788056_2 aminoacyl-histidine dipeptidase K01270 - - 3.644e-235 737.0
SHD1_k127_2788056_20 Ankyrin repeats (many copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001312 259.0
SHD1_k127_2788056_21 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000001616 215.0
SHD1_k127_2788056_22 PFAM Anti sigma-E protein RseA family protein K03597 - - 0.000000000000000000000000000000000000000000000000000000005376 202.0
SHD1_k127_2788056_23 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000155 196.0
SHD1_k127_2788056_24 DsrC like protein K11179 - - 0.000000000000000000000000000000000000000000000000000002827 191.0
SHD1_k127_2788056_25 PFAM Glutathione S-transferase, N-terminal domain K11209 - - 0.00000000000000000000000000000000000000000000000000003347 194.0
SHD1_k127_2788056_26 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000007684 194.0
SHD1_k127_2788056_27 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000002005 184.0
SHD1_k127_2788056_28 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000000000217 175.0
SHD1_k127_2788056_29 Lipid A 3-O-deacylase (PagL) - - - 0.0000000000000000000000000000000000000000000001338 174.0
SHD1_k127_2788056_3 PFAM peptidase S1 and S6 chymotrypsin Hap K04771 - 3.4.21.107 7.855e-214 672.0
SHD1_k127_2788056_30 - - - - 0.000000000000000000000000000000000000000003218 157.0
SHD1_k127_2788056_31 PQ loop repeat K15383 - - 0.00000000000000000000000000000003456 127.0
SHD1_k127_2788056_32 - - - - 0.0000000000000000000000000000006905 127.0
SHD1_k127_2788056_33 - - - - 0.00000000000000000001614 93.0
SHD1_k127_2788056_34 - - - - 0.00000000000000000003194 96.0
SHD1_k127_2788056_35 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.00000000000000000005142 96.0
SHD1_k127_2788056_36 - - - - 0.0000000000000000001353 91.0
SHD1_k127_2788056_37 Protein of unknown function (DUF2621) - - - 0.000000005542 65.0
SHD1_k127_2788056_38 Phosphoglycerate mutase family - - - 0.00000001949 63.0
SHD1_k127_2788056_4 Alpha/beta hydrolase family K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 548.0
SHD1_k127_2788056_40 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000004284 53.0
SHD1_k127_2788056_5 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 510.0
SHD1_k127_2788056_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 486.0
SHD1_k127_2788056_7 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 460.0
SHD1_k127_2788056_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 457.0
SHD1_k127_2788056_9 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 436.0
SHD1_k127_2794750_0 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 452.0
SHD1_k127_2794750_1 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 452.0
SHD1_k127_2794750_2 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 430.0
SHD1_k127_2794750_3 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000000000000000001221 211.0
SHD1_k127_2794750_4 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000003064 179.0
SHD1_k127_2797204_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1520.0
SHD1_k127_2797204_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 2.037e-202 642.0
SHD1_k127_2797204_2 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001083 245.0
SHD1_k127_2797204_3 Peptidase family M23 K08259 - 3.4.24.75 0.00000000000004104 72.0
SHD1_k127_2797204_4 - - - - 0.00000000001265 64.0
SHD1_k127_2859464_0 PFAM TonB-dependent receptor plug K02014,K16089 - - 2.321e-257 807.0
SHD1_k127_2859464_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 6.363e-204 636.0
SHD1_k127_2859464_10 TolA C-terminal K03646 - - 0.0000000000000000000000000000000000000000000001592 179.0
SHD1_k127_2859464_2 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 603.0
SHD1_k127_2859464_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 370.0
SHD1_k127_2859464_4 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008377 361.0
SHD1_k127_2859464_5 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 355.0
SHD1_k127_2859464_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000003353 224.0
SHD1_k127_2859464_7 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000000000000000466 200.0
SHD1_k127_2859464_8 OmpA family K03640 - - 0.000000000000000000000000000000000000000000000000000001091 196.0
SHD1_k127_2859464_9 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000000000000000000000000000003355 187.0
SHD1_k127_2870726_0 AAA ATPase domain - - - 0.0 1069.0
SHD1_k127_2870726_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 340.0
SHD1_k127_2870726_2 AIG2-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001257 259.0
SHD1_k127_2880186_0 CobB/CobQ-like glutamine amidotransferase domain K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 550.0
SHD1_k127_2880186_1 Belongs to the precorrin methyltransferase family K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 402.0
SHD1_k127_2880186_2 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 293.0
SHD1_k127_2880186_3 cobalt transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000342 244.0
SHD1_k127_2880186_4 CbiX K03795 - 4.99.1.3 0.00000000000000000000000000000000000000001577 155.0
SHD1_k127_2880186_5 cobalt transporter - - - 0.00000003467 60.0
SHD1_k127_2880186_6 - - - - 0.00001336 48.0
SHD1_k127_2887438_0 ATP synthase (C/AC39) subunit K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 441.0
SHD1_k127_2887438_1 V-type ATPase 116kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000003195 234.0
SHD1_k127_2887438_2 - - - - 0.000000000000000000000000004887 117.0
SHD1_k127_2901533_0 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 3.55e-244 756.0
SHD1_k127_2901533_1 DNA polymerase alpha chain like domain K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 440.0
SHD1_k127_2901533_10 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000106 250.0
SHD1_k127_2901533_11 Segregation and condensation complex subunit ScpB K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000076 243.0
SHD1_k127_2901533_12 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000002419 222.0
SHD1_k127_2901533_13 Copper resistance protein D - - - 0.000000000000000000000000000000000000000000000000000001925 200.0
SHD1_k127_2901533_14 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000000000000000000000000000000000006963 156.0
SHD1_k127_2901533_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 422.0
SHD1_k127_2901533_3 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 391.0
SHD1_k127_2901533_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 358.0
SHD1_k127_2901533_5 SpoU rRNA Methylase family K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 323.0
SHD1_k127_2901533_6 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005839 317.0
SHD1_k127_2901533_7 TIGRFAM Sua5 YciO YrdC YwlC family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 315.0
SHD1_k127_2901533_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 289.0
SHD1_k127_2901533_9 Histidine kinase K20975 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001841 280.0
SHD1_k127_2903978_0 Putative diguanylate phosphodiesterase - - - 8.135e-252 791.0
SHD1_k127_2903978_1 Histidine kinase K02482 - 2.7.13.3 1.099e-197 624.0
SHD1_k127_2903978_2 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 560.0
SHD1_k127_2903978_3 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 456.0
SHD1_k127_2903978_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 390.0
SHD1_k127_2903978_5 SMART Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 304.0
SHD1_k127_2903978_6 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000004963 217.0
SHD1_k127_2903978_7 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000000000000000000000000000000000000000000001548 202.0
SHD1_k127_2903978_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000000000002425 166.0
SHD1_k127_2903978_9 - - - - 0.0001025 46.0
SHD1_k127_2912218_0 General secretory system II protein E domain protein K02454,K02652,K12276 - - 1.249e-298 923.0
SHD1_k127_2912218_1 PFAM type II and III secretion system protein K02453 - - 1.218e-206 659.0
SHD1_k127_2912218_10 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 361.0
SHD1_k127_2912218_11 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000635 286.0
SHD1_k127_2912218_12 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000337 258.0
SHD1_k127_2912218_13 MlaC protein K07323 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001598 250.0
SHD1_k127_2912218_14 - - - - 0.0000000000000000000000000000000000000000000000000000001149 201.0
SHD1_k127_2912218_15 - - - - 0.000000000000000000000000002193 119.0
SHD1_k127_2912218_16 Belongs to the BolA IbaG family - - - 0.000000000000000000000000002974 113.0
SHD1_k127_2912218_17 response to antibiotic K07122 - - 0.00000000000000000004171 93.0
SHD1_k127_2912218_2 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 618.0
SHD1_k127_2912218_3 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 586.0
SHD1_k127_2912218_4 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000858 504.0
SHD1_k127_2912218_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000514 494.0
SHD1_k127_2912218_6 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 470.0
SHD1_k127_2912218_7 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 440.0
SHD1_k127_2912218_8 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 427.0
SHD1_k127_2912218_9 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 376.0
SHD1_k127_2928828_0 Sugar (and other) transporter - - - 1.093e-245 768.0
SHD1_k127_2928828_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 629.0
SHD1_k127_2928828_2 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 569.0
SHD1_k127_2928828_3 ABC transporter C-terminal domain K15738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 543.0
SHD1_k127_2928828_4 ZIP Zinc transporter K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 362.0
SHD1_k127_2928828_5 pfkB family carbohydrate kinase K03272,K21344 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000001255 254.0
SHD1_k127_2928828_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000003 174.0
SHD1_k127_2928828_7 OmpA-like transmembrane domain - - - 0.0001078 52.0
SHD1_k127_2931370_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 554.0
SHD1_k127_2931370_1 interspecies interaction between organisms - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 403.0
SHD1_k127_2931370_2 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 371.0
SHD1_k127_2931370_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000002126 234.0
SHD1_k127_2945257_0 General secretory system II protein E domain protein K02454,K02652,K12276 - - 6.378e-244 766.0
SHD1_k127_2945257_1 Virulence factor membrane-bound polymerase, C-terminal - - - 1.037e-198 636.0
SHD1_k127_2945257_10 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.00000000000000000005114 97.0
SHD1_k127_2945257_2 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 480.0
SHD1_k127_2945257_3 CHASE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 361.0
SHD1_k127_2945257_4 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000000000000000000000002668 260.0
SHD1_k127_2945257_5 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000000000000000000000000000000001488 221.0
SHD1_k127_2945257_6 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000000000000000000005318 228.0
SHD1_k127_2945257_7 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000002322 166.0
SHD1_k127_2945257_8 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000000001029 135.0
SHD1_k127_2945257_9 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000002278 127.0
SHD1_k127_2961607_0 Bacterial-like globin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 325.0
SHD1_k127_2961607_1 PFAM Dual specificity protein phosphatase K14165 - 3.1.3.16,3.1.3.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007324 327.0
SHD1_k127_2961607_2 transcription factor binding - - - 0.000000000000000000000000000000000000000000000000000000004432 201.0
SHD1_k127_2961607_3 transcription factor binding - - - 0.000000000000000000000000000000000000000000000000000000005538 201.0
SHD1_k127_2961607_4 GTP-binding domain protein K06945 - - 0.00000000000000000000000000000000000000000000000000001621 195.0
SHD1_k127_2961607_5 Roadblock/LC7 domain K07131 - - 0.0000000000000000000000000001056 119.0
SHD1_k127_2961607_6 - - - - 0.0000000000437 71.0
SHD1_k127_2961710_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1379.0
SHD1_k127_2961710_1 histidine kinase HAMP region domain protein - - - 1.56e-227 717.0
SHD1_k127_2961710_10 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007977 407.0
SHD1_k127_2961710_11 LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008387 404.0
SHD1_k127_2961710_12 VanZ like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 399.0
SHD1_k127_2961710_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 358.0
SHD1_k127_2961710_14 Serine aminopeptidase, S33 K07018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 323.0
SHD1_k127_2961710_15 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000006617 251.0
SHD1_k127_2961710_16 Hemerythrin HHE cation binding domain protein K07216 - - 0.00000000000000000000000000000000000000000000000000000000000000003712 226.0
SHD1_k127_2961710_17 COG2346, Truncated hemoglobins K03406,K06886 GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - 0.0000000000000000000000000000000000000000000000000000000000000005796 222.0
SHD1_k127_2961710_18 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
SHD1_k127_2961710_19 Protein of unknown function (DUF494) K03747 - - 0.00000000000000000000000000000000000000000000000000000003262 199.0
SHD1_k127_2961710_2 THUMP K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 599.0
SHD1_k127_2961710_20 membrane K08973 - - 0.0000000000000000000000000000000000000000000000000000001959 196.0
SHD1_k127_2961710_21 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000000000006863 190.0
SHD1_k127_2961710_22 Ferredoxin - - - 0.0000000000000000000000000000000000000000000000005139 177.0
SHD1_k127_2961710_23 TIGRFAM transcriptional regulator, Rrf2 family K13771 - - 0.00000000000000000000000000000000000000000000003859 176.0
SHD1_k127_2961710_3 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 597.0
SHD1_k127_2961710_4 PFAM ABC transporter related K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 510.0
SHD1_k127_2961710_5 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 522.0
SHD1_k127_2961710_6 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 487.0
SHD1_k127_2961710_7 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 439.0
SHD1_k127_2961710_8 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 430.0
SHD1_k127_2961710_9 Oxidoreductase FAD-binding domain K14581 - 1.18.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 426.0
SHD1_k127_2969790_0 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.0 1044.0
SHD1_k127_2969790_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0 1028.0
SHD1_k127_2969790_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 290.0
SHD1_k127_2969790_3 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001429 272.0
SHD1_k127_2969790_4 - - - - 0.00008193 51.0
SHD1_k127_2969808_0 PFAM type II secretion system protein E K02670 - - 8.349e-212 661.0
SHD1_k127_2969808_1 PFAM type II secretion system protein E K02669,K12203 - - 8.262e-204 641.0
SHD1_k127_2969808_2 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 334.0
SHD1_k127_2969808_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000851 277.0
SHD1_k127_2969808_4 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10111 - - 0.000000000000000000000000000000000000000000000000114 184.0
SHD1_k127_2969808_5 DNA-binding protein VF530 - - - 0.0000000000000000000000000001346 115.0
SHD1_k127_2971117_0 fad dependent oxidoreductase K07137 - - 3.4e-240 746.0
SHD1_k127_2971117_1 Diguanylate cyclase (GGDEF) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 608.0
SHD1_k127_2971117_2 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007519 552.0
SHD1_k127_2975727_0 TonB-dependent Receptor Plug Domain K02014 - - 1.65e-221 709.0
SHD1_k127_2975727_1 DAHP synthetase I family K03856 - 2.5.1.54 7.319e-215 672.0
SHD1_k127_2975727_10 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000001253 197.0
SHD1_k127_2975727_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000007848 189.0
SHD1_k127_2975727_12 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000001585 141.0
SHD1_k127_2975727_13 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000000000000246 145.0
SHD1_k127_2975727_14 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000005763 126.0
SHD1_k127_2975727_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 548.0
SHD1_k127_2975727_3 PFAM ATP-binding region ATPase domain protein K15011 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 537.0
SHD1_k127_2975727_4 Bacterial regulatory proteins, tetR family K05501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 332.0
SHD1_k127_2975727_5 HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003176 327.0
SHD1_k127_2975727_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 329.0
SHD1_k127_2975727_7 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004311 274.0
SHD1_k127_2975727_8 Bacterial regulatory protein, Fis family K15012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000109 274.0
SHD1_k127_2975727_9 Domain of unknown function (DUF1841) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004531 264.0
SHD1_k127_3015067_0 PFAM thiamine pyrophosphate K01652 - 2.2.1.6 0.0 1024.0
SHD1_k127_3015067_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 3.694e-271 840.0
SHD1_k127_3015067_2 PFAM permease YjgP YjgQ family protein K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 520.0
SHD1_k127_3015067_3 PFAM permease YjgP YjgQ family protein K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 511.0
SHD1_k127_3015067_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005262 278.0
SHD1_k127_3015067_5 ACT domain K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006801 274.0
SHD1_k127_3015067_6 Protein of unknown function (DUF3106) - - - 0.000000000000000121 84.0
SHD1_k127_3017577_0 AsmA family K07289 - - 2.113e-291 912.0
SHD1_k127_3017577_1 AAA domain, putative AbiEii toxin, Type IV TA system K06926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 546.0
SHD1_k127_3017577_10 positive regulation of growth - - - 0.0000000000000000001182 91.0
SHD1_k127_3017577_11 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00002591 50.0
SHD1_k127_3017577_2 endonuclease III K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 537.0
SHD1_k127_3017577_3 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 494.0
SHD1_k127_3017577_4 surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 358.0
SHD1_k127_3017577_5 RloB-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001752 271.0
SHD1_k127_3017577_6 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000000000004542 159.0
SHD1_k127_3017577_7 membrane - - - 0.000000000000000000000000000000000000000008703 156.0
SHD1_k127_3017577_8 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000000000000008878 140.0
SHD1_k127_3017577_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000007505 138.0
SHD1_k127_3040078_0 Major Facilitator Superfamily - - - 9.127e-205 644.0
SHD1_k127_3040078_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009419 436.0
SHD1_k127_3040078_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 346.0
SHD1_k127_3040078_3 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 322.0
SHD1_k127_3040078_4 Glycoprotease family K14742 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 294.0
SHD1_k127_3040078_5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002184 272.0
SHD1_k127_3040078_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789,K14742 - 2.3.1.128 0.000000000000000000000000000000000000000003273 161.0
SHD1_k127_3040078_7 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000004362 93.0
SHD1_k127_3105031_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1229.0
SHD1_k127_3105031_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.09e-266 823.0
SHD1_k127_3105031_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008746 477.0
SHD1_k127_3105031_3 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 436.0
SHD1_k127_3105031_4 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 309.0
SHD1_k127_3105031_5 PFAM Appr-1-p processing domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 291.0
SHD1_k127_3105031_6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000406 281.0
SHD1_k127_3126291_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1454.0
SHD1_k127_3126291_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 2.164e-268 843.0
SHD1_k127_3126291_10 DNA helicase - - - 0.000000000000001533 76.0
SHD1_k127_3126291_12 Protein of unknown function (DUF2892) - - - 0.000006165 53.0
SHD1_k127_3126291_13 - - - - 0.000006251 51.0
SHD1_k127_3126291_2 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 569.0
SHD1_k127_3126291_3 PFAM UMUC domain protein DNA-repair protein K03502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 552.0
SHD1_k127_3126291_4 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 473.0
SHD1_k127_3126291_5 3'-5' exonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 312.0
SHD1_k127_3126291_6 Uncharacterized protein conserved in bacteria (DUF2239) K09965 - - 0.00000000000000000000000000000000000000000000000000000000000002792 220.0
SHD1_k127_3126291_7 Belongs to the peptidase S24 family K03503 - - 0.0000000000000000000000000000000000000000000000000007202 186.0
SHD1_k127_3126291_8 GGDEF Domain - - - 0.00000000000000000000000000000000000000000000007587 184.0
SHD1_k127_3126291_9 - - - - 0.0000000000000000000000000000000001912 136.0
SHD1_k127_312945_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1602.0
SHD1_k127_312945_1 May be involved in recombinational repair of damaged DNA K03631 - - 5.121e-253 796.0
SHD1_k127_312945_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 513.0
SHD1_k127_312945_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 454.0
SHD1_k127_312945_4 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 416.0
SHD1_k127_312945_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 396.0
SHD1_k127_312945_6 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000004508 205.0
SHD1_k127_312945_7 Winged helix-turn-helix transcription repressor, HrcA DNA-binding K03705 - - 0.0000000000000000000000000000000000000000000000000001111 186.0
SHD1_k127_312945_8 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000000000001182 190.0
SHD1_k127_312945_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000000000000000142 127.0
SHD1_k127_3142015_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0 1223.0
SHD1_k127_3142015_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.002e-257 800.0
SHD1_k127_3142015_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005214 267.0
SHD1_k127_3142015_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07032 - - 0.000000000000000000000000000000000000000000000000000000000000000004591 228.0
SHD1_k127_3142015_12 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000000000000000000000000000000000000000461 187.0
SHD1_k127_3142015_13 Protein of unknown function (DUF2782) - - - 0.00000000000000000000000000000406 124.0
SHD1_k127_3142015_14 TIGRFAM phosphate regulon sensor kinase PhoR K07636 - 2.7.13.3 0.0001133 44.0
SHD1_k127_3142015_2 Phosphoribulokinase / Uridine kinase family K00855 - 2.7.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007435 533.0
SHD1_k127_3142015_3 pfkB family carbohydrate kinase K00852,K00856 - 2.7.1.15,2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 506.0
SHD1_k127_3142015_4 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 478.0
SHD1_k127_3142015_5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 461.0
SHD1_k127_3142015_6 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 427.0
SHD1_k127_3142015_7 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 422.0
SHD1_k127_3142015_8 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 366.0
SHD1_k127_3142015_9 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005289 276.0
SHD1_k127_3142663_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365,K05366 - 2.4.1.129,3.4.16.4 0.0 1305.0
SHD1_k127_3142663_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1282.0
SHD1_k127_3142663_10 - - - - 0.0000000000000000000000000000000000000000000003951 170.0
SHD1_k127_3142663_11 COG2199 FOG GGDEF domain - - - 0.000000000000000000000000000000000000000005841 168.0
SHD1_k127_3142663_13 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000007211 143.0
SHD1_k127_3142663_15 OmpA-like transmembrane domain - - - 0.000001474 57.0
SHD1_k127_3142663_2 serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 503.0
SHD1_k127_3142663_3 PFAM ABC transporter related K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009017 479.0
SHD1_k127_3142663_4 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 447.0
SHD1_k127_3142663_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 320.0
SHD1_k127_3142663_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004592 267.0
SHD1_k127_3142663_7 Peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001038 249.0
SHD1_k127_3142663_8 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000005094 226.0
SHD1_k127_3142663_9 photosynthesis K12132,K20543 - 2.7.11.1 0.000000000000000000000000000000000000000000000000494 181.0
SHD1_k127_3194948_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.0 1204.0
SHD1_k127_3194948_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 529.0
SHD1_k127_3194948_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005794 471.0
SHD1_k127_3205121_0 fad dependent oxidoreductase K07137 - - 7.075e-307 944.0
SHD1_k127_3205121_1 ABC transporter transmembrane region K06147 - - 5.628e-306 947.0
SHD1_k127_3205121_10 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 318.0
SHD1_k127_3205121_11 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 318.0
SHD1_k127_3205121_12 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 295.0
SHD1_k127_3205121_13 molybdenum cofactor K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 287.0
SHD1_k127_3205121_14 PFAM Dihaem cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 283.0
SHD1_k127_3205121_15 Lysin motif K06194 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001616 285.0
SHD1_k127_3205121_16 Cytochrome b/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004422 254.0
SHD1_k127_3205121_17 - - - - 0.0000000000000000000000000000000000000000000000000000001783 201.0
SHD1_k127_3205121_18 Domain of unknown function (DUF1924) - - - 0.00000000000000000000000000000000000000000000000008221 181.0
SHD1_k127_3205121_19 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000006258 167.0
SHD1_k127_3205121_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 518.0
SHD1_k127_3205121_22 Domain of unknown function (DUF4468) with TBP-like fold - - - 0.000000001648 70.0
SHD1_k127_3205121_3 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 446.0
SHD1_k127_3205121_4 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 436.0
SHD1_k127_3205121_5 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 416.0
SHD1_k127_3205121_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 413.0
SHD1_k127_3205121_7 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 402.0
SHD1_k127_3205121_8 PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase 1 K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 353.0
SHD1_k127_3205121_9 mechanosensitive - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009074 331.0
SHD1_k127_3247753_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 433.0
SHD1_k127_3247753_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 349.0
SHD1_k127_3247753_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 315.0
SHD1_k127_3247753_3 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 302.0
SHD1_k127_3247753_4 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000278 188.0
SHD1_k127_3247753_5 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000009313 177.0
SHD1_k127_3247753_6 Competence protein K02237 - - 0.000000000000000000000000000000004574 133.0
SHD1_k127_3247753_7 - - - - 0.000000000000000000004142 93.0
SHD1_k127_3337338_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 8.463e-230 713.0
SHD1_k127_3337338_1 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 1.333e-227 706.0
SHD1_k127_3337338_2 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 545.0
SHD1_k127_3337338_3 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 496.0
SHD1_k127_3337338_4 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 483.0
SHD1_k127_3354639_0 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 452.0
SHD1_k127_3354639_1 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 376.0
SHD1_k127_3354639_2 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 344.0
SHD1_k127_3354639_3 PFAM Type II secretion system F domain K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 281.0
SHD1_k127_3354639_4 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000006119 216.0
SHD1_k127_3354639_5 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000000002993 91.0
SHD1_k127_3373731_0 serine threonine protein kinase K12132 - 2.7.11.1 0.0 1291.0
SHD1_k127_3373731_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 544.0
SHD1_k127_3373731_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 407.0
SHD1_k127_3373731_3 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 404.0
SHD1_k127_3373731_4 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 363.0
SHD1_k127_3373731_5 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 345.0
SHD1_k127_3373731_6 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 336.0
SHD1_k127_3373731_7 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000008022 203.0
SHD1_k127_3416672_0 ABC-type uncharacterized transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 550.0
SHD1_k127_3416672_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 360.0
SHD1_k127_3416672_2 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002214 285.0
SHD1_k127_3416672_3 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000001463 190.0
SHD1_k127_3416672_4 - - - - 0.00000000000000000000000000000000005871 135.0
SHD1_k127_3467033_0 SMART von Willebrand factor type A - - - 7.51e-299 933.0
SHD1_k127_3467033_1 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 7.14e-216 670.0
SHD1_k127_3467033_10 Domain of unknown function (DUF4124) - - - 0.0000000000000000000000000006338 122.0
SHD1_k127_3467033_11 - - - - 0.0000008636 54.0
SHD1_k127_3467033_2 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 553.0
SHD1_k127_3467033_3 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 443.0
SHD1_k127_3467033_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 370.0
SHD1_k127_3467033_5 Carbonic anhydrase K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009907 322.0
SHD1_k127_3467033_6 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 287.0
SHD1_k127_3467033_7 ATPase associated with various cellular activities, AAA_5 K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 284.0
SHD1_k127_3467033_8 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003944 282.0
SHD1_k127_3467033_9 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000006039 220.0
SHD1_k127_3507858_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 4.12e-256 793.0
SHD1_k127_3507858_1 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 1.436e-224 706.0
SHD1_k127_3507858_2 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 599.0
SHD1_k127_3507858_3 Glycine cleavage system K03567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009285 328.0
SHD1_k127_3507858_4 Belongs to the UPF0225 family K09858 - - 0.0000000000000000000000000000000000000000000000000000576 189.0
SHD1_k127_3518005_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 3.1e-233 736.0
SHD1_k127_3518005_1 Belongs to the DegT DnrJ EryC1 family - - - 1.858e-221 689.0
SHD1_k127_3518005_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 604.0
SHD1_k127_3518005_3 Glycosyl transferase family 2 K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009848 491.0
SHD1_k127_3518005_4 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 479.0
SHD1_k127_3518005_5 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 317.0
SHD1_k127_3518005_6 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000732 297.0
SHD1_k127_3518005_7 Small Multidrug Resistance protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000007978 231.0
SHD1_k127_3518005_8 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000000000000000000007958 198.0
SHD1_k127_3518005_9 Trm112p-like protein K09791 - - 0.00000000000000000000000001707 109.0
SHD1_k127_3530501_0 glutamate synthase alpha subunit domain protein K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2699.0
SHD1_k127_3530501_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0 1069.0
SHD1_k127_3530501_10 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 314.0
SHD1_k127_3530501_11 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 283.0
SHD1_k127_3530501_12 VirC1 protein K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 283.0
SHD1_k127_3530501_13 Cytochrome C1 family K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001132 274.0
SHD1_k127_3530501_14 Planctomycete cytochrome C - - - 0.0000000000000000000000000000000000000000000000002087 178.0
SHD1_k127_3530501_15 NYN domain - - - 0.0000000000000000000000000000000000000000000000006089 175.0
SHD1_k127_3530501_16 PFAM cytochrome c class I K08738 - - 0.000000000000000000000000000000000000000000000000619 177.0
SHD1_k127_3530501_17 PFAM cytochrome c class I K08738 - - 0.00000000000000000000000000000002469 128.0
SHD1_k127_3530501_19 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000744 70.0
SHD1_k127_3530501_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1039.0
SHD1_k127_3530501_3 TIGRFAM glutamate synthase, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 3.395e-300 922.0
SHD1_k127_3530501_4 PFAM FAD linked oxidase domain protein K00102 - 1.1.2.4 1.099e-229 718.0
SHD1_k127_3530501_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 7.984e-228 706.0
SHD1_k127_3530501_6 Cytochrome b(N-terminal)/b6/petB K00412 - - 2.279e-226 705.0
SHD1_k127_3530501_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 418.0
SHD1_k127_3530501_8 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 356.0
SHD1_k127_3530501_9 PFAM Sodium calcium exchanger membrane region K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 353.0
SHD1_k127_35368_0 Belongs to the peptidase S16 family - - - 9.845e-300 940.0
SHD1_k127_35368_1 Heat shock 70 kDa protein K04043 - - 3.938e-259 804.0
SHD1_k127_35368_2 ribosomal large subunit export from nucleus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004987 248.0
SHD1_k127_3552489_0 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 501.0
SHD1_k127_3552489_1 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003485 269.0
SHD1_k127_3552489_2 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004359 258.0
SHD1_k127_3552489_3 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000000000000000000000000006816 203.0
SHD1_k127_3552489_4 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000002864 108.0
SHD1_k127_3552489_5 Membrane fusogenic activity K09806 - - 0.0000000000000000000000003454 106.0
SHD1_k127_3555080_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1358.0
SHD1_k127_3555080_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.025e-270 836.0
SHD1_k127_3555246_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1581.0
SHD1_k127_3555246_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 0.0 1031.0
SHD1_k127_3555246_10 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000008072 168.0
SHD1_k127_3555246_11 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000000000000000000000000000757 147.0
SHD1_k127_3555246_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 8.08e-247 765.0
SHD1_k127_3555246_3 metal-dependent phosphohydrolase HD sub domain - - - 2.6e-240 753.0
SHD1_k127_3555246_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 3.241e-229 716.0
SHD1_k127_3555246_5 DAHP synthetase I family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 504.0
SHD1_k127_3555246_6 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 463.0
SHD1_k127_3555246_7 Rhodanese Homology Domain K06917 - - 0.000000000000000000000000000000000000000000000000000000000000002338 222.0
SHD1_k127_3555246_8 Outer membrane protein V K07274 - - 0.00000000000000000000000000000000000000000000000000000000000001531 224.0
SHD1_k127_3555246_9 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000000000000002367 194.0
SHD1_k127_3559940_0 major facilitator superfamily K03446 - - 6.121e-258 801.0
SHD1_k127_3559940_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 584.0
SHD1_k127_3559940_2 PFAM secretion protein HlyD family protein K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 461.0
SHD1_k127_3559940_3 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007853 308.0
SHD1_k127_3559940_4 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 283.0
SHD1_k127_3559940_5 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000007913 256.0
SHD1_k127_3559940_6 Transcription regulator that can specifically activate or repress expression of target genes K06075 - - 0.000000000000000000000000000000000000000000000003986 179.0
SHD1_k127_3559940_7 - - - - 0.000000000000000000002863 96.0
SHD1_k127_3569099_0 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007133 581.0
SHD1_k127_3569099_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 585.0
SHD1_k127_3569099_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 366.0
SHD1_k127_3569099_3 Peptidyl-prolyl cis-trans isomerase K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000413 263.0
SHD1_k127_3569099_4 Bacterial protein of unknown function (DUF899) K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000126 255.0
SHD1_k127_3569099_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000001285 225.0
SHD1_k127_3569099_6 VirC1 protein K03496 - - 0.00000000000000000000000000000000000000000000004389 179.0
SHD1_k127_3569099_7 NlpB/DapX lipoprotein K07287 - - 0.0003797 46.0
SHD1_k127_3571098_0 PFAM CHASE2 domain - - - 1.157e-261 816.0
SHD1_k127_3571098_1 Oxidoreductase FAD-binding domain protein K00523,K18248 - 1.17.1.1 1.289e-202 642.0
SHD1_k127_3571098_2 Hydrogenase formation hypA family K04654 GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 602.0
SHD1_k127_3571098_3 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 375.0
SHD1_k127_3571098_4 Domain of unknown function (DUF4382) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 368.0
SHD1_k127_3571098_5 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004678 279.0
SHD1_k127_3571098_6 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000000000000001931 186.0
SHD1_k127_3571098_7 pathogenesis - - - 0.0000000000000000000000000000000004359 139.0
SHD1_k127_3581328_0 Vitamin B12 dependent methionine synthase activation region K00548 - 2.1.1.13 0.0 2310.0
SHD1_k127_3581328_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1454.0
SHD1_k127_3581328_10 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000005936 210.0
SHD1_k127_3581328_12 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000000002019 190.0
SHD1_k127_3581328_13 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000002102 159.0
SHD1_k127_3581328_14 BON domain - - - 0.0000000000000000000000000000000000000002156 155.0
SHD1_k127_3581328_15 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000000000000000000002239 149.0
SHD1_k127_3581328_16 Protein of unknown function (DUF2288) - - - 0.00000000000000000000000000000000008341 136.0
SHD1_k127_3581328_17 TIGRFAM alkylphosphonate utilization operon protein PhnA K06193 - - 0.000000000000000000000002144 102.0
SHD1_k127_3581328_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 1.467e-204 645.0
SHD1_k127_3581328_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 474.0
SHD1_k127_3581328_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 452.0
SHD1_k127_3581328_5 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 394.0
SHD1_k127_3581328_6 Abortive infection C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 353.0
SHD1_k127_3581328_7 LppC putative lipoprotein K07121 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 347.0
SHD1_k127_3581328_8 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 298.0
SHD1_k127_3581328_9 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002863 272.0
SHD1_k127_3606873_0 Peptidase family U32 C-terminal domain K08303 - - 3.965e-278 857.0
SHD1_k127_3606873_1 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 469.0
SHD1_k127_3606873_2 Belongs to the peptidase S1B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 316.0
SHD1_k127_3606873_3 Domain of unknown function (DUF386) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000027 266.0
SHD1_k127_3606873_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000005567 210.0
SHD1_k127_3606873_5 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000000000000000000000000007812 175.0
SHD1_k127_3606873_6 HD domain K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000006338 173.0
SHD1_k127_3612822_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 2.655e-227 709.0
SHD1_k127_3612822_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 600.0
SHD1_k127_3612822_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 553.0
SHD1_k127_3612822_3 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 513.0
SHD1_k127_3612822_4 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 287.0
SHD1_k127_3612822_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006459 280.0
SHD1_k127_3612822_6 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008459 237.0
SHD1_k127_3612822_7 Required for insertion of 4Fe-4S clusters K15724 - - 0.0000000000000000000000000000000000000000000000000000000000000001018 223.0
SHD1_k127_3612822_8 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000000006569 186.0
SHD1_k127_3612822_9 - - - - 0.0000000000000000000722 90.0
SHD1_k127_3621506_0 PFAM peptidase S1 and S6 chymotrypsin Hap K04691,K04772 - - 6.917e-194 610.0
SHD1_k127_3621506_1 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 532.0
SHD1_k127_3621506_2 4 iron, 4 sulfur cluster binding K02574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006575 529.0
SHD1_k127_3621506_3 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 399.0
SHD1_k127_3621506_4 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 314.0
SHD1_k127_3621506_5 CBS domain containing protein K07168 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 293.0
SHD1_k127_3621506_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000009207 125.0
SHD1_k127_3632561_0 type III restriction protein res subunit K01153 - 3.1.21.3 0.0 1159.0
SHD1_k127_3632561_1 PAS domain containing protein K07315,K07675 - 2.7.13.3,3.1.3.3 0.0 1144.0
SHD1_k127_3632561_10 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 339.0
SHD1_k127_3632561_11 Thiopurine S-methyltransferase (TPMT) K00569 - 2.1.1.67 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 334.0
SHD1_k127_3632561_12 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 317.0
SHD1_k127_3632561_13 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 313.0
SHD1_k127_3632561_14 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 289.0
SHD1_k127_3632561_15 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000147 273.0
SHD1_k127_3632561_16 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005688 280.0
SHD1_k127_3632561_17 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000002501 237.0
SHD1_k127_3632561_18 TIGRFAM Nucleotidyltransferase substrate binding protein, HI0074 - - - 0.0000000000000000000000000000000000000000000000000000000008022 203.0
SHD1_k127_3632561_19 Carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000002545 183.0
SHD1_k127_3632561_2 N-6 DNA methylase K03427 - 2.1.1.72 5.997e-293 905.0
SHD1_k127_3632561_20 PFAM Nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000003238 162.0
SHD1_k127_3632561_21 PFAM Plasmid stabilisation system K06218 - - 0.0000000000000000000000000000000005525 133.0
SHD1_k127_3632561_22 Domain of unknown function (DUF4389) - - - 0.000000000000000000000002182 105.0
SHD1_k127_3632561_23 Antitoxin component of a toxin-antitoxin (TA) module K18923 - - 0.00000000000008987 74.0
SHD1_k127_3632561_24 - - - - 0.0000000000002325 72.0
SHD1_k127_3632561_25 - - - - 0.0000000000006346 75.0
SHD1_k127_3632561_26 Protein of unknown function (DUF3460) - - - 0.000000004935 59.0
SHD1_k127_3632561_3 PFAM CHAD domain containing protein - - - 1.366e-210 664.0
SHD1_k127_3632561_4 HI0933-like protein K07007 - - 8.483e-207 650.0
SHD1_k127_3632561_5 Hsp90 protein K04079 - - 2.78e-200 627.0
SHD1_k127_3632561_6 protein conserved in bacteria K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 583.0
SHD1_k127_3632561_7 Dienelactone hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 400.0
SHD1_k127_3632561_8 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 362.0
SHD1_k127_3632561_9 crp fnr family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 350.0
SHD1_k127_363948_0 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 549.0
SHD1_k127_363948_1 fructose-bisphosphate aldolase K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 441.0
SHD1_k127_363948_2 PFAM heat shock protein DnaJ K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 336.0
SHD1_k127_363948_3 MerR HTH family regulatory protein K18997 - - 0.0000000000000000000000000000000000001648 144.0
SHD1_k127_3652054_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008902 400.0
SHD1_k127_3652054_1 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 291.0
SHD1_k127_3652054_2 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 285.0
SHD1_k127_3652054_3 - - - - 0.0000000000000000000000000000000000007918 145.0
SHD1_k127_3698930_0 cellulose synthase K20541 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 572.0
SHD1_k127_3698930_1 cellulose synthase operon C domain protein K20543 - - 0.00000000000000000000000000000000000000000000000000001969 211.0
SHD1_k127_3698930_2 cellulose synthase K00694 - 2.4.1.12 0.00000000000000000001557 97.0
SHD1_k127_3753307_0 Histidine Phosphotransfer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 500.0
SHD1_k127_3753307_1 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 315.0
SHD1_k127_3753307_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000001084 110.0
SHD1_k127_3791173_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 1.56e-215 670.0
SHD1_k127_3791173_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 469.0
SHD1_k127_3791173_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 406.0
SHD1_k127_3791173_3 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 359.0
SHD1_k127_3791173_4 - - - - 0.000000000000000000000003229 111.0
SHD1_k127_3796517_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 6.088e-229 715.0
SHD1_k127_3796517_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 1.608e-202 637.0
SHD1_k127_3796517_10 Carbohydrate-selective porin, OprB family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 355.0
SHD1_k127_3796517_11 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 351.0
SHD1_k127_3796517_12 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 317.0
SHD1_k127_3796517_13 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 314.0
SHD1_k127_3796517_14 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 301.0
SHD1_k127_3796517_15 Bacterial dnaA protein K10763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003924 295.0
SHD1_k127_3796517_16 Gram-negative porin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 299.0
SHD1_k127_3796517_17 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 286.0
SHD1_k127_3796517_18 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003199 250.0
SHD1_k127_3796517_19 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003102 248.0
SHD1_k127_3796517_2 PFAM AIR synthase related protein domain protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 592.0
SHD1_k127_3796517_20 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000003961 239.0
SHD1_k127_3796517_21 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001022 237.0
SHD1_k127_3796517_22 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000007175 226.0
SHD1_k127_3796517_23 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000000000000000001005 220.0
SHD1_k127_3796517_24 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000000000008397 199.0
SHD1_k127_3796517_25 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000000000000003039 110.0
SHD1_k127_3796517_27 aspartyl protease K06985 - - 0.000000000451 67.0
SHD1_k127_3796517_28 tetratricopeptide repeat - - - 0.0006703 51.0
SHD1_k127_3796517_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 537.0
SHD1_k127_3796517_4 cytochrome c peroxidase K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 513.0
SHD1_k127_3796517_5 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 400.0
SHD1_k127_3796517_6 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 397.0
SHD1_k127_3796517_7 Indole-3-glycerol phosphate synthase K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 382.0
SHD1_k127_3796517_8 TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 361.0
SHD1_k127_3796517_9 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 362.0
SHD1_k127_3807803_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 0.0 2011.0
SHD1_k127_3807803_1 Protein of unknown function - - - 0.0 1029.0
SHD1_k127_3807803_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 5.812e-262 813.0
SHD1_k127_3807803_3 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 9.908e-221 687.0
SHD1_k127_3807803_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 472.0
SHD1_k127_3807803_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003254 272.0
SHD1_k127_3807803_6 PFAM cytochrome c class I K08738 - - 0.000000000000000000004687 100.0
SHD1_k127_3807803_7 CRS1_YhbY K07574 - - 0.0001147 45.0
SHD1_k127_3848153_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1221.0
SHD1_k127_3848153_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 1.685e-210 663.0
SHD1_k127_3848153_2 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 436.0
SHD1_k127_3848153_3 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 411.0
SHD1_k127_3848153_4 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 391.0
SHD1_k127_3848153_5 Belongs to the GbsR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 371.0
SHD1_k127_3848153_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 294.0
SHD1_k127_3848153_7 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006727 297.0
SHD1_k127_3848153_8 Frataxin-like domain K06202 - - 0.000000000000000000000000000000000000000002826 157.0
SHD1_k127_3848153_9 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.0000000000000002966 78.0
SHD1_k127_3882342_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 6.872e-279 868.0
SHD1_k127_3882342_1 Mur ligase family, catalytic domain K01924 - 6.3.2.8 2.279e-244 761.0
SHD1_k127_3882342_10 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 463.0
SHD1_k127_3882342_11 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 443.0
SHD1_k127_3882342_12 MraZ protein, putative antitoxin-like K03925 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 290.0
SHD1_k127_3882342_13 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001307 252.0
SHD1_k127_3882342_14 POTRA domain, FtsQ-type - - - 0.000000000000000000000000000000000000000000000003311 181.0
SHD1_k127_3882342_15 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000009738 172.0
SHD1_k127_3882342_16 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000000000000000005823 118.0
SHD1_k127_3882342_17 - - - - 0.00000000008566 67.0
SHD1_k127_3882342_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 1.204e-230 718.0
SHD1_k127_3882342_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.58e-216 682.0
SHD1_k127_3882342_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 1.141e-201 636.0
SHD1_k127_3882342_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 1.474e-200 635.0
SHD1_k127_3882342_6 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 576.0
SHD1_k127_3882342_7 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 564.0
SHD1_k127_3882342_8 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 488.0
SHD1_k127_3882342_9 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 466.0
SHD1_k127_3906251_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.646e-300 925.0
SHD1_k127_3906251_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 541.0
SHD1_k127_3906251_2 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 365.0
SHD1_k127_3906251_3 Belongs to the peptidase S1B family - - - 0.000000000000000000000000000000000000000000000001269 184.0
SHD1_k127_3906251_6 domain protein - - - 0.0000007675 54.0
SHD1_k127_3928138_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.675e-278 861.0
SHD1_k127_3928138_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 6.955e-225 701.0
SHD1_k127_3928138_10 Colicin V production protein K03558 - - 0.0000001002 54.0
SHD1_k127_3928138_2 PFAM Mur ligase middle domain protein K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 610.0
SHD1_k127_3928138_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 435.0
SHD1_k127_3928138_4 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006617 251.0
SHD1_k127_3928138_5 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000001322 233.0
SHD1_k127_3928138_6 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000001497 189.0
SHD1_k127_3928138_7 Sporulation related domain K03749 - - 0.000000000000000000000000000000000000000188 157.0
SHD1_k127_3928138_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000002707 119.0
SHD1_k127_3928138_9 PFAM Colicin V production protein K03558 - - 0.000000000000000000001409 98.0
SHD1_k127_396386_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K02021,K11085 - - 5.121e-283 879.0
SHD1_k127_396386_1 response regulator receiver - - - 3.239e-240 781.0
SHD1_k127_396386_10 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 374.0
SHD1_k127_396386_11 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 357.0
SHD1_k127_396386_12 Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 349.0
SHD1_k127_396386_13 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 349.0
SHD1_k127_396386_14 PFAM cobalamin (vitamin B12) biosynthesis CbiX K03795 - 4.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 310.0
SHD1_k127_396386_15 Nitroreductase family K02303,K04719 - 1.13.11.79,2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 295.0
SHD1_k127_396386_16 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
SHD1_k127_396386_17 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000005928 241.0
SHD1_k127_396386_18 Response regulator receiver K02658 - - 0.000000000000000000000000000000000000000000000000000371 186.0
SHD1_k127_396386_19 Phosphoglycerate mutase family K02226,K15634 - 3.1.3.73,5.4.2.12 0.0000000000000000000000000000000000000000000000000005183 195.0
SHD1_k127_396386_2 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 2.48e-227 715.0
SHD1_k127_396386_20 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14392 - - 0.0000000000000000000000000000000000000000000000001341 176.0
SHD1_k127_396386_21 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000002818 162.0
SHD1_k127_396386_22 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.000000000000000000000000000000000001358 142.0
SHD1_k127_396386_23 CheW-like domain - - - 0.000000000000000000000000000000002822 135.0
SHD1_k127_396386_24 - - - - 0.00000000000000000000004889 104.0
SHD1_k127_396386_3 precorrin-6y C5,15-methyltransferase K00595,K02191 - 2.1.1.132,2.1.1.196 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 546.0
SHD1_k127_396386_4 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 509.0
SHD1_k127_396386_5 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009544 472.0
SHD1_k127_396386_6 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 439.0
SHD1_k127_396386_7 chemotaxis, protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 451.0
SHD1_k127_396386_8 PFAM aminotransferase, class I K02225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 399.0
SHD1_k127_396386_9 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 373.0
SHD1_k127_4009369_0 PFAM cytochrome bd ubiquinol oxidase subunit I K00425 - 1.10.3.14 0.0 997.0
SHD1_k127_4009369_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 1.692e-242 753.0
SHD1_k127_4009369_2 PFAM sigma-54 factor interaction domain-containing protein K06714 - - 1.189e-238 742.0
SHD1_k127_4009369_3 TIGRFAM cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 4.47e-236 731.0
SHD1_k127_4009369_4 Pyridoxal-phosphate dependent enzyme K12339 GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 546.0
SHD1_k127_4009369_5 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 522.0
SHD1_k127_4009369_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 353.0
SHD1_k127_4009369_7 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000002333 251.0
SHD1_k127_4009369_8 Cyd operon protein YbgE (Cyd_oper_YbgE) - - - 0.000000000000000000000000000000000000004641 147.0
SHD1_k127_4009369_9 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000005573 145.0
SHD1_k127_4032629_0 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 499.0
SHD1_k127_4032629_1 serine threonine protein kinase - - - 0.0000000000000000000000000000001471 140.0
SHD1_k127_4032629_2 FecR protein - - - 0.000000000000000000000000000005983 134.0
SHD1_k127_4032629_3 Caspase domain - - - 0.0000000000001386 83.0
SHD1_k127_4140999_0 Elongation factor Tu GTP binding domain K00956 - 2.7.7.4 2.189e-248 769.0
SHD1_k127_4140999_1 Phosphoadenosine phosphosulfate reductase family K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 580.0
SHD1_k127_4140999_10 Mitomycin resistance protein K07343 - - 0.00000000000000000000000001199 111.0
SHD1_k127_4140999_11 - - - - 0.0000000000000000000000000691 112.0
SHD1_k127_4140999_12 Domain of unknown function (DUF4034) - - - 0.000000000000000000008362 105.0
SHD1_k127_4140999_13 Histidine kinase-like ATPase domain - - - 0.0000000000000002848 79.0
SHD1_k127_4140999_14 Sel1-like repeats. K07126 - - 0.00000746 58.0
SHD1_k127_4140999_15 Mitomycin resistance protein K07343 - - 0.00006735 46.0
SHD1_k127_4140999_2 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 365.0
SHD1_k127_4140999_3 nitrite sulfite reductase hemoprotein beta-component ferrodoxin domain protein K00381,K00392 - 1.8.1.2,1.8.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001234 259.0
SHD1_k127_4140999_4 PFAM Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001119 241.0
SHD1_k127_4140999_5 - - - - 0.000000000000000000000000000000000000000000001458 174.0
SHD1_k127_4140999_6 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.00000000000000000000000000000000000001649 158.0
SHD1_k127_4140999_7 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000001 138.0
SHD1_k127_4140999_8 Plasmid maintenance system killer protein K07334 - - 0.00000000000000000000000000000000006158 135.0
SHD1_k127_4140999_9 TPM domain K06872 - - 0.0000000000000000000000000004335 127.0
SHD1_k127_4145731_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0 1092.0
SHD1_k127_4145731_1 MgsA AAA+ ATPase C terminal K07478 - - 7.069e-203 639.0
SHD1_k127_4145731_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 4.023e-194 610.0
SHD1_k127_4145731_3 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 623.0
SHD1_k127_4145731_4 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 482.0
SHD1_k127_4145731_5 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 309.0
SHD1_k127_4145731_6 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 296.0
SHD1_k127_4145731_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007586 266.0
SHD1_k127_4145731_8 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters K02170 - 3.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000456 246.0
SHD1_k127_4145731_9 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000000002792 220.0
SHD1_k127_4165966_0 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 463.0
SHD1_k127_4165966_1 Virulence factor BrkB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 333.0
SHD1_k127_4165966_2 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 335.0
SHD1_k127_4165966_3 Belongs to the UPF0310 family - - - 0.000000000000000000000000000000000000000000000000000000000007908 213.0
SHD1_k127_4165966_5 TfoX C-terminal domain K07343 - - 0.0000000009888 59.0
SHD1_k127_4165966_6 - - - - 0.000000009691 56.0
SHD1_k127_4176218_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0 1013.0
SHD1_k127_4176218_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 7.739e-245 762.0
SHD1_k127_4176218_10 Ribosomal protein L9, N-terminal domain K02939 - - 0.0000000000000000000000000000000000000000000000000000000000000004184 224.0
SHD1_k127_4176218_11 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000000000000000000132 217.0
SHD1_k127_4176218_12 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.00000000000000000000000000000000000000000000001188 171.0
SHD1_k127_4176218_13 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000000000000000003084 153.0
SHD1_k127_4176218_14 DNA replication, synthesis of RNA primer K02686 - - 0.00000000000000000000000001051 111.0
SHD1_k127_4176218_15 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000003312 67.0
SHD1_k127_4176218_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 1.95e-242 765.0
SHD1_k127_4176218_3 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006211 538.0
SHD1_k127_4176218_4 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000718 452.0
SHD1_k127_4176218_5 Bacterial protein of unknown function (DUF898) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 322.0
SHD1_k127_4176218_6 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008348 309.0
SHD1_k127_4176218_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 297.0
SHD1_k127_4176218_8 Belongs to the UPF0178 family K09768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006119 265.0
SHD1_k127_4176218_9 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001261 252.0
SHD1_k127_4185873_0 Belongs to the NifD NifK NifE NifN family K02592 - - 1.253e-198 633.0
SHD1_k127_4185873_1 Belongs to the NifD NifK NifE NifN family K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 518.0
SHD1_k127_4185873_2 Nitrogen fixation protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001903 238.0
SHD1_k127_4185873_3 Nitrogen fixation protein NifX K02596 - - 0.00000000000000000000000000000000000000000000000000000000000000005574 226.0
SHD1_k127_4185873_4 Ferredoxin III, nif-specific - - - 0.000000000000000000000000000000000000000004167 161.0
SHD1_k127_4185873_5 Rop-like - - - 0.0000000000000000002448 89.0
SHD1_k127_4185873_6 NifQ K15790 - - 0.00000000000000005839 87.0
SHD1_k127_4186719_0 LysR substrate binding domain K13634 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005113 508.0
SHD1_k127_4186719_1 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 353.0
SHD1_k127_4285914_0 Sugar (and other) transporter - - - 1.307e-238 742.0
SHD1_k127_4285914_1 TRANSCRIPTIONal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005975 264.0
SHD1_k127_4285914_2 - - - - 0.000000000000000000000000000000000000000000000000000000000006721 209.0
SHD1_k127_4285914_3 - - - - 0.0000000000000000000000000001041 123.0
SHD1_k127_4285914_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000001835 102.0
SHD1_k127_4318385_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 9.018e-270 832.0
SHD1_k127_4318385_1 TIGRFAM ATP-dependent Clp protease, ATP-binding subunit clpA K03694 - - 1.347e-207 647.0
SHD1_k127_4318385_2 PFAM Haloacid dehalogenase domain protein hydrolase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 438.0
SHD1_k127_4318385_3 - - - - 0.0000000000000000000000000000000000000000000000000001115 192.0
SHD1_k127_4331091_0 General secretion pathway protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 439.0
SHD1_k127_4331091_1 peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 344.0
SHD1_k127_4331091_2 type II secretion system protein E K02454,K02652,K12276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 312.0
SHD1_k127_4341181_0 general secretion pathway protein D K02453 - - 3.795e-236 750.0
SHD1_k127_4341181_1 type II secretion system protein E K02454,K02652,K12276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 498.0
SHD1_k127_4341181_2 Type II secretion system protein C K02452 - - 0.00000006841 62.0
SHD1_k127_4351753_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 2.132e-257 802.0
SHD1_k127_4351753_1 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 492.0
SHD1_k127_4351753_10 ABC transporter - - - 0.000000000003393 74.0
SHD1_k127_4351753_2 sister chromatid segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000321 248.0
SHD1_k127_4351753_3 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000001763 199.0
SHD1_k127_4351753_4 - - - - 0.0000000000000000000000000000000000000000000004152 176.0
SHD1_k127_4351753_5 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000216 179.0
SHD1_k127_4351753_6 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000008236 165.0
SHD1_k127_4351753_7 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000008745 138.0
SHD1_k127_4351753_8 FecR protein - - - 0.000000000000000000005343 105.0
SHD1_k127_4351753_9 Tetratricopeptide repeat - - - 0.0000000000000000007396 96.0
SHD1_k127_4354701_0 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 422.0
SHD1_k127_4354701_1 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 397.0
SHD1_k127_4354701_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003159 389.0
SHD1_k127_4354701_3 PFAM UPF0103 Mediator of ErbB2-driven cell motility K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 346.0
SHD1_k127_4354701_4 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 334.0
SHD1_k127_4354701_5 PFAM AMMECR1 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000294 248.0
SHD1_k127_4354701_6 Radical SAM K04069 - 1.97.1.4 0.00000000000000000000000000000000000005664 142.0
SHD1_k127_4356533_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1030.0
SHD1_k127_4356533_1 Capsule biosynthesis GfcC - - - 4.416e-272 867.0
SHD1_k127_4356533_10 Domain of unknown function (DUF1972) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 352.0
SHD1_k127_4356533_11 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 316.0
SHD1_k127_4356533_12 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 314.0
SHD1_k127_4356533_13 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 284.0
SHD1_k127_4356533_14 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000001191 259.0
SHD1_k127_4356533_15 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000006312 211.0
SHD1_k127_4356533_16 PFAM outer membrane chaperone Skp (OmpH) K06142 - - 0.0000000000000000000000000000000000000000000000000007716 189.0
SHD1_k127_4356533_17 (Lipo)protein - - - 0.0000000000000000000000000000000000002834 150.0
SHD1_k127_4356533_2 SMART PDZ DHR GLGF domain protein K11749 - - 5.465e-205 646.0
SHD1_k127_4356533_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 1.218e-197 627.0
SHD1_k127_4356533_4 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 498.0
SHD1_k127_4356533_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 482.0
SHD1_k127_4356533_6 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 415.0
SHD1_k127_4356533_7 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 413.0
SHD1_k127_4356533_8 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 391.0
SHD1_k127_4356533_9 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 389.0
SHD1_k127_4360481_0 HI0933-like protein K07007 - - 1.359e-203 639.0
SHD1_k127_4360481_1 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 584.0
SHD1_k127_4360481_2 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 300.0
SHD1_k127_4360481_3 PFAM Helix-turn-helix, type 11 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008859 256.0
SHD1_k127_4360481_4 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000003126 213.0
SHD1_k127_4360481_5 ethyl tert-butyl ether degradation - - - 0.00000000000000000000000000000000000000007155 153.0
SHD1_k127_4360481_6 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000000007935 146.0
SHD1_k127_4360481_7 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000000000000000004118 138.0
SHD1_k127_4360481_8 - - - - 0.00000000000000000000000000000000003568 139.0
SHD1_k127_4385568_0 ABC transporter C-terminal domain K15738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 600.0
SHD1_k127_4385568_1 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 378.0
SHD1_k127_4385568_2 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 366.0
SHD1_k127_4385568_3 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 309.0
SHD1_k127_4385568_4 Thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000001098 246.0
SHD1_k127_4392917_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 9.873e-275 852.0
SHD1_k127_4392917_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.383e-263 813.0
SHD1_k127_4392917_10 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001024 240.0
SHD1_k127_4392917_11 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000000000000000000000000000269 216.0
SHD1_k127_4392917_12 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.00000000000000000000000000000000000000000000000000000115 192.0
SHD1_k127_4392917_13 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000000000000000001257 181.0
SHD1_k127_4392917_14 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000000000000000004116 161.0
SHD1_k127_4392917_15 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000000007449 135.0
SHD1_k127_4392917_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 8.752e-260 801.0
SHD1_k127_4392917_3 PFAM aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 2.393e-206 647.0
SHD1_k127_4392917_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 2.893e-199 624.0
SHD1_k127_4392917_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 593.0
SHD1_k127_4392917_6 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 503.0
SHD1_k127_4392917_7 SMART phosphoesterase PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 362.0
SHD1_k127_4392917_8 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 301.0
SHD1_k127_4392917_9 DJ-1/PfpI family K03152 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005262 271.0
SHD1_k127_4419543_0 alpha-glucan phosphorylase K00688 - 2.4.1.1 0.0 1430.0
SHD1_k127_4419543_1 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 2.796e-213 674.0
SHD1_k127_4419543_10 SpoIIAA-like - - - 0.000000000000000000000000000000000000000000000000000000000006344 209.0
SHD1_k127_4419543_11 antisigma factor binding K04749 - - 0.00000000000000000000000002335 112.0
SHD1_k127_4419543_12 antisigma factor binding K04749 - - 0.00000000000000000000004642 102.0
SHD1_k127_4419543_13 Histidine kinase-like ATPase domain - - - 0.0000000000000000001762 103.0
SHD1_k127_4419543_14 Uncharacterized ACR, COG1399 K07040 - - 0.000000001053 61.0
SHD1_k127_4419543_15 Integrase core domain - - - 0.000000001235 61.0
SHD1_k127_4419543_2 Alcohol dehydrogenase GroES-like domain K00001,K18369 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 536.0
SHD1_k127_4419543_3 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 493.0
SHD1_k127_4419543_4 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 403.0
SHD1_k127_4419543_5 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 366.0
SHD1_k127_4419543_6 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 368.0
SHD1_k127_4419543_7 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 346.0
SHD1_k127_4419543_8 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003349 266.0
SHD1_k127_4419543_9 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001912 242.0
SHD1_k127_442222_0 TIGRFAM DNA internalization-related competence protein ComEC Rec2 K02238 - - 7.04e-313 975.0
SHD1_k127_442222_1 MscS Mechanosensitive ion channel - - - 1.063e-237 744.0
SHD1_k127_442222_10 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001879 267.0
SHD1_k127_442222_11 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007638 270.0
SHD1_k127_442222_12 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000791 244.0
SHD1_k127_442222_13 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000000000000000000007969 226.0
SHD1_k127_442222_14 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000001517 162.0
SHD1_k127_442222_15 Helix-turn-helix domain K15539 - - 0.00000000000000000000000000000000000000000006141 173.0
SHD1_k127_442222_16 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.000000000000000000000000000009022 118.0
SHD1_k127_442222_2 metal-dependent phosphohydrolase HD sub domain K07814 - - 9.697e-230 721.0
SHD1_k127_442222_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 2.837e-226 704.0
SHD1_k127_442222_4 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 3.304e-203 636.0
SHD1_k127_442222_5 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 9.276e-199 632.0
SHD1_k127_442222_6 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 551.0
SHD1_k127_442222_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004508 458.0
SHD1_k127_442222_8 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 347.0
SHD1_k127_442222_9 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005384 282.0
SHD1_k127_4544987_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.364e-231 726.0
SHD1_k127_4544987_1 Amino acid permease K03294 - - 1.622e-228 715.0
SHD1_k127_4544987_10 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 469.0
SHD1_k127_4544987_11 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008892 307.0
SHD1_k127_4544987_12 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000811 282.0
SHD1_k127_4544987_2 phosphomannomutase K01840 - 5.4.2.8 1.601e-226 709.0
SHD1_k127_4544987_3 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 3.059e-207 653.0
SHD1_k127_4544987_4 Oxidoreductase FAD-binding domain protein K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 542.0
SHD1_k127_4544987_5 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 537.0
SHD1_k127_4544987_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 517.0
SHD1_k127_4544987_7 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 508.0
SHD1_k127_4544987_8 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007107 497.0
SHD1_k127_4544987_9 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 485.0
SHD1_k127_4579529_0 B3/4 domain K01890 - 6.1.1.20 1.314e-215 673.0
SHD1_k127_4579529_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 1.943e-204 637.0
SHD1_k127_4579529_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000000000000000001261 213.0
SHD1_k127_4613805_0 Protein of unknown function, DUF255 K06888 - - 5.516e-301 936.0
SHD1_k127_4613805_1 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 504.0
SHD1_k127_4613805_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 346.0
SHD1_k127_4613805_3 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 335.0
SHD1_k127_4613805_4 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 295.0
SHD1_k127_4613805_5 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000006637 254.0
SHD1_k127_4613805_6 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000001644 245.0
SHD1_k127_4613805_7 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000008023 211.0
SHD1_k127_4613805_8 Protein of unknown function (DUF559) - - - 0.000000000000000000000000000000000000000000005897 167.0
SHD1_k127_4630364_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic domain K01886 - 6.1.1.18 1.09e-294 904.0
SHD1_k127_4630364_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 4.543e-260 807.0
SHD1_k127_4630364_2 general secretion pathway protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008193 246.0
SHD1_k127_4630364_3 membrane - - - 0.000000000000000000000000000000000000000000000000000002808 200.0
SHD1_k127_4630364_4 - - - - 0.000000000000000000000000000000000000000000000000000007042 203.0
SHD1_k127_4632388_0 FAD dependent oxidoreductase K00313 - - 4.007e-228 711.0
SHD1_k127_4632388_1 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 539.0
SHD1_k127_4632388_2 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 420.0
SHD1_k127_4632388_3 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000001821 204.0
SHD1_k127_4632388_4 Could be a 3Fe-4S cluster-containing protein K03855 - - 0.0000000000000000000000000000000000000000000001058 169.0
SHD1_k127_4632388_5 Ferredoxin - - - 0.00000000000000000000000000000000000000000002218 163.0
SHD1_k127_4632388_6 - - - - 0.0000000000000000000000000000000000000003525 153.0
SHD1_k127_4632388_7 May protect the nitrogenase Fe-Mo protein from oxidative damage K02595 - - 0.00000000000000000000000001675 113.0
SHD1_k127_4755371_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1517.0
SHD1_k127_4755371_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 413.0
SHD1_k127_4755371_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003251 261.0
SHD1_k127_4755371_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000008903 207.0
SHD1_k127_4755371_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000000000000000000002127 199.0
SHD1_k127_4774101_0 TIGRFAM heavy metal efflux pump, CzcA family K07787 - - 0.0 1640.0
SHD1_k127_4774101_1 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 3.743e-278 864.0
SHD1_k127_4774101_10 - - - - 0.0000000000000000000000000000001006 130.0
SHD1_k127_4774101_11 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000000000000000000000001202 118.0
SHD1_k127_4774101_12 Copper binding periplasmic protein CusF K07810 - - 0.00000000000008382 76.0
SHD1_k127_4774101_14 Tautomerase enzyme K01821 - 5.3.2.6 0.0000006864 51.0
SHD1_k127_4774101_2 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 9.837e-208 651.0
SHD1_k127_4774101_3 TIGRFAM efflux transporter, RND family, MFP subunit K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 494.0
SHD1_k127_4774101_4 PFAM outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 462.0
SHD1_k127_4774101_5 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 322.0
SHD1_k127_4774101_7 - - - - 0.000000000000000000000000000000000000000000000000000000001101 205.0
SHD1_k127_4774101_8 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000000000000000000000000000000001562 192.0
SHD1_k127_4774101_9 Ppx GppA phosphatase - - - 0.00000000000000000000000000000000000000206 153.0
SHD1_k127_4784640_0 Glycosyl transferase family 21 K00694 - 2.4.1.12 1.428e-275 867.0
SHD1_k127_4784640_1 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 598.0
SHD1_k127_4784640_2 TIGRFAM glycine oxidase ThiO K03153 - 1.4.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 466.0
SHD1_k127_4784640_3 PFAM glycoside hydrolase family 8 K01179,K20542 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 344.0
SHD1_k127_4784640_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001069 258.0
SHD1_k127_4784640_5 TYPE 4 fimbrial BIOGENESIS K02672 - - 0.000000000000000000000000000000000000000000000000006024 189.0
SHD1_k127_4784640_6 type IV pilus modification protein PilV K02671 - - 0.000000000000000000000000000000000000000000000003903 182.0
SHD1_k127_4784640_7 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000004089 187.0
SHD1_k127_4784640_8 protein transport across the cell outer membrane K08084 - - 0.000000000000000000000000000003315 127.0
SHD1_k127_4784640_9 Type IV minor pilin ComP, DNA uptake sequence receptor K02655 - - 0.0000000000000000001274 95.0
SHD1_k127_4830321_0 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 3.027e-241 752.0
SHD1_k127_4830321_1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 511.0
SHD1_k127_4830321_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 433.0
SHD1_k127_4830321_3 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 320.0
SHD1_k127_4830321_4 Belongs to the peptidase S24 family K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 290.0
SHD1_k127_4830321_5 VanZ like family - - - 0.00000000000000000000000000000000000000000000000002917 182.0
SHD1_k127_4830321_6 acr, cog1430 K09005 - - 0.00000000000000000000000000000009841 134.0
SHD1_k127_4831307_0 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.0 1441.0
SHD1_k127_4831307_1 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 590.0
SHD1_k127_4831307_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 421.0
SHD1_k127_4831307_3 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 424.0
SHD1_k127_4831307_4 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 389.0
SHD1_k127_4831307_5 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000005311 229.0
SHD1_k127_4831307_6 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000009948 120.0
SHD1_k127_4831307_7 Diguanylate cyclase - - - 0.000000237 53.0
SHD1_k127_4844492_0 general secretion pathway protein K K02460 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 309.0
SHD1_k127_4844492_1 Galactose oxidase, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002988 277.0
SHD1_k127_4844492_10 general secretion pathway protein K02457 - - 0.00000000000000003678 88.0
SHD1_k127_4844492_11 AraC-binding-like domain - - - 0.00000000001493 74.0
SHD1_k127_4844492_12 ig-like, plexins, transcription factors - - - 0.0000000001646 71.0
SHD1_k127_4844492_13 antisigma factor binding K04749 - - 0.00000004563 59.0
SHD1_k127_4844492_2 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003511 266.0
SHD1_k127_4844492_3 general secretion pathway protein G K02456 - - 0.00000000000000000000000000000000000000000000000000000000000000000009256 233.0
SHD1_k127_4844492_4 General secretion pathway protein K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.0000000000000000000000000000000000000000000002571 174.0
SHD1_k127_4844492_5 General secretion pathway protein I K02458 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000002716 139.0
SHD1_k127_4844492_6 General secretion pathway K02462 - - 0.00000000000000000000000000002451 123.0
SHD1_k127_4844492_7 AraC-binding-like domain - - - 0.00000000000000000000000000002625 130.0
SHD1_k127_4855177_0 AcrB/AcrD/AcrF family - - - 0.0 1476.0
SHD1_k127_4855177_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1106.0
SHD1_k127_4855177_10 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 335.0
SHD1_k127_4855177_11 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000005245 268.0
SHD1_k127_4855177_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001295 226.0
SHD1_k127_4855177_13 Protein of unknown function (DUF2892) - - - 0.00000000000000000000000000485 111.0
SHD1_k127_4855177_14 PFAM Tetratricopeptide repeat K07126 - - 0.0000000000000000000003295 102.0
SHD1_k127_4855177_15 Protein of unknown function (DUF2934) - - - 0.0000000000000001115 84.0
SHD1_k127_4855177_2 Domain of unknown function (DUF1926) K22451 - 2.4.1.25 1.343e-281 879.0
SHD1_k127_4855177_3 PFAM peptidase M17 leucyl aminopeptidase domain protein K01255 - 3.4.11.1 3.523e-252 784.0
SHD1_k127_4855177_4 Belongs to the glycosyl hydrolase 57 family - - - 3.902e-237 746.0
SHD1_k127_4855177_5 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 2.901e-222 694.0
SHD1_k127_4855177_6 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 525.0
SHD1_k127_4855177_7 Belongs to the GPI family K01810 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009882 507.0
SHD1_k127_4855177_8 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 338.0
SHD1_k127_4855177_9 PFAM ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000928 328.0
SHD1_k127_4878542_0 PFAM metallophosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 466.0
SHD1_k127_4878542_1 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 322.0
SHD1_k127_4878542_2 AIR synthase related protein, N-terminal domain K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 315.0
SHD1_k127_4878542_3 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000004586 192.0
SHD1_k127_4886428_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 9.077e-214 670.0
SHD1_k127_4886428_1 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000699 580.0
SHD1_k127_4886428_2 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 588.0
SHD1_k127_4886428_3 S4 RNA-binding domain K06182 - 5.4.99.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008449 399.0
SHD1_k127_4886428_4 UPF0056 inner membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 305.0
SHD1_k127_4886428_5 PFAM Excinuclease ABC C subunit domain protein K07461 - - 0.00000000000000000000000000000000002828 137.0
SHD1_k127_4887657_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 3.204e-221 695.0
SHD1_k127_4887657_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 488.0
SHD1_k127_4887657_2 - - - - 0.0000001995 58.0
SHD1_k127_4889367_0 Nitrogenase cofactor biosynthesis protein NifB K02585 - - 2.068e-276 857.0
SHD1_k127_4889367_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 475.0
SHD1_k127_4889367_10 PFAM NifZ family protein K02597 - - 0.000000000000000000000000001083 114.0
SHD1_k127_4889367_11 NifT/FixU protein K02593 - - 0.000000000000000000000000001466 112.0
SHD1_k127_4889367_13 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00000004314 55.0
SHD1_k127_4889367_14 - - - - 0.00000006728 58.0
SHD1_k127_4889367_2 PFAM EAL domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 368.0
SHD1_k127_4889367_3 SIR2-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 327.0
SHD1_k127_4889367_4 LRV protein FeS4 cluster - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001312 259.0
SHD1_k127_4889367_5 Ferredoxin K04755 - - 0.0000000000000000000000000000000000000005416 150.0
SHD1_k127_4889367_6 Iron-sulphur cluster biosynthesis - - - 0.000000000000000000000000000000000000003109 149.0
SHD1_k127_4889367_7 NifZ domain K02597 - - 0.00000000000000000000000000000000001683 137.0
SHD1_k127_4889367_8 4Fe-4S binding domain - - - 0.0000000000000000000000000000000001096 136.0
SHD1_k127_4889367_9 Protein of unknown function (DUF3024) - - - 0.00000000000000000000000000004792 123.0
SHD1_k127_4891730_0 AcrB/AcrD/AcrF family - - - 0.0 1503.0
SHD1_k127_4891730_1 Multi-copper - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 466.0
SHD1_k127_4891730_2 Copper binding proteins, plastocyanin/azurin family K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 402.0
SHD1_k127_4891730_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 398.0
SHD1_k127_4891730_4 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 336.0
SHD1_k127_4891730_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000002216 266.0
SHD1_k127_4891730_6 cytochrome C, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001985 267.0
SHD1_k127_4891730_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000003022 227.0
SHD1_k127_4891730_8 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000000000000000000000000005328 142.0
SHD1_k127_4891730_9 Copper binding periplasmic protein CusF K07810 - - 0.000000000000000001291 89.0
SHD1_k127_4896029_0 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 473.0
SHD1_k127_4896029_1 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 451.0
SHD1_k127_4896029_2 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 406.0
SHD1_k127_4896029_3 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004563 278.0
SHD1_k127_4896029_4 - - - - 0.00000000000000000000000000000001123 128.0
SHD1_k127_4896029_5 Domain of unknown function (DUF4381) - - - 0.000000000000000000000000004204 117.0
SHD1_k127_4901191_0 PFAM aminotransferase class I and II K00812 - 2.6.1.1 6.48e-228 709.0
SHD1_k127_4901191_1 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 396.0
SHD1_k127_4901191_2 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 358.0
SHD1_k127_4901191_3 translation initiation factor activity - - - 0.00000000000000000002333 96.0
SHD1_k127_4902540_0 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 467.0
SHD1_k127_4902540_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000185 249.0
SHD1_k127_4902540_2 - - - - 0.0000000000000000000000000000000000000000249 155.0
SHD1_k127_4902540_3 Protein of unknown function (DUF433) - - - 0.000000000000000000000000007136 111.0
SHD1_k127_4902540_4 Short C-terminal domain - - - 0.000000000000005589 81.0
SHD1_k127_4928013_0 Likely ribonuclease with RNase H fold. K06959 - - 0.0 1258.0
SHD1_k127_4928013_1 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.104e-305 949.0
SHD1_k127_4928013_10 KR domain K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 402.0
SHD1_k127_4928013_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004201 275.0
SHD1_k127_4928013_12 PFAM lipolytic protein G-D-S-L family K01073 - 3.1.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001116 276.0
SHD1_k127_4928013_13 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000001988 221.0
SHD1_k127_4928013_14 NlpB/DapX lipoprotein K07287 - - 0.0000000000000000000000001119 115.0
SHD1_k127_4928013_15 FeoA K04758 - - 0.0000000000000000000003465 104.0
SHD1_k127_4928013_16 - - - - 0.000000000000000000001594 101.0
SHD1_k127_4928013_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 6.55e-220 694.0
SHD1_k127_4928013_3 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014,K16089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 604.0
SHD1_k127_4928013_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 536.0
SHD1_k127_4928013_5 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 527.0
SHD1_k127_4928013_6 secreted hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 521.0
SHD1_k127_4928013_7 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 516.0
SHD1_k127_4928013_8 TRAP transporter T-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 462.0
SHD1_k127_4928013_9 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 465.0
SHD1_k127_4933816_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 4.688e-263 816.0
SHD1_k127_4933816_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 9.254e-226 706.0
SHD1_k127_4933816_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 395.0
SHD1_k127_4933816_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000394 205.0
SHD1_k127_4933816_4 YGGT family K02221 - - 0.0000000000000000000000000000000000000000000000000006385 195.0
SHD1_k127_4933816_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000001696 154.0
SHD1_k127_4933816_6 DUF167 K09131 - - 0.000000000000000000000000000000000000003549 147.0
SHD1_k127_4933816_7 - - - - 0.00000000000000000000000227 104.0
SHD1_k127_4935543_0 methyltransferase activity K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 405.0
SHD1_k127_4935543_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006172 259.0
SHD1_k127_4935543_2 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003096 243.0
SHD1_k127_4935543_3 membrane organization K20543 - - 0.00000000000000000000000000000000000000000000000000000000000000004783 241.0
SHD1_k127_4935543_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000005585 204.0
SHD1_k127_4935543_5 - - - - 0.000000000000000000000000000000000000000000000000000000003276 203.0
SHD1_k127_4935543_6 - - - - 0.00000000000000000000000000000000000002246 147.0
SHD1_k127_4935543_7 PFAM cytochrome c class I K08738 - - 0.00000000000000000000000007406 111.0
SHD1_k127_4953053_0 Threonine synthase N terminus K01733 - 4.2.3.1 1.369e-288 889.0
SHD1_k127_4953053_1 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 492.0
SHD1_k127_4953053_2 Domain of unknown function (DUF1956) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005667 263.0
SHD1_k127_4953053_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007511 249.0
SHD1_k127_4953053_4 Endonuclease containing a URI domain K07461 - - 0.0000000000000000000000000000000000000001704 152.0
SHD1_k127_4958474_0 Bacterial lipid A biosynthesis acyltransferase K02517,K12974 - 2.3.1.241,2.3.1.242 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004434 512.0
SHD1_k127_4958474_1 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 505.0
SHD1_k127_4958474_2 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 337.0
SHD1_k127_4958474_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000001127 147.0
SHD1_k127_499091_0 Carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 562.0
SHD1_k127_499091_1 Domain of unknown function (DUF3393) K08306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 494.0
SHD1_k127_499091_2 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000005138 231.0
SHD1_k127_499091_3 Bacterial-like globin - - - 0.00000000000000000000000000000000000000000000000000000001503 205.0
SHD1_k127_499091_4 Domain of unknown function (DUF4149) - - - 0.0000000000000000000000000000000000000000000000001718 181.0
SHD1_k127_4998327_0 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0 1123.0
SHD1_k127_4998327_1 CoA-substrate-specific enzyme activase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 569.0
SHD1_k127_4998327_2 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000000000000000000000000000000000000008129 237.0
SHD1_k127_4998327_3 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000001644 213.0
SHD1_k127_4998327_5 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000001431 130.0
SHD1_k127_4998338_0 COG0474 Cation transport ATPase K01531 - 3.6.3.2 0.0 1395.0
SHD1_k127_4998338_1 Phosphorylase superfamily K00772,K03815 - 2.4.2.28 0.000000000000000000000000000000000000000000000008132 175.0
SHD1_k127_4998338_2 response regulator K02483,K07666,K07774 - - 0.0000000000000000000000000000000000000000005136 160.0
SHD1_k127_5009399_0 MltA specific insert domain K08304 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 545.0
SHD1_k127_5009399_1 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 456.0
SHD1_k127_5009399_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 435.0
SHD1_k127_5009399_3 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 419.0
SHD1_k127_5009399_4 Phosphoesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 399.0
SHD1_k127_5009399_5 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000502 268.0
SHD1_k127_5009399_6 ApaG domain K06195 - - 0.0000000000000000000000000000000000000000000000000000003685 196.0
SHD1_k127_5009399_7 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0000000000000000000000000000000000000000000000000000009693 192.0
SHD1_k127_5057381_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.023e-226 712.0
SHD1_k127_5057381_1 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 488.0
SHD1_k127_5057381_10 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000003608 209.0
SHD1_k127_5057381_11 SMART CoA-binding domain protein K06929 - - 0.000000000000000000000000000000000000000000000000000000001013 205.0
SHD1_k127_5057381_12 Rhodanese domain protein - - - 0.000000000000000000000000000000000000000000000000000182 187.0
SHD1_k127_5057381_13 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000002173 171.0
SHD1_k127_5057381_14 Chemoreceptor zinc-binding domain - - - 0.000000000000000000000000000000000000000021 157.0
SHD1_k127_5057381_15 Chemoreceptor zinc-binding domain - - - 0.00000000000000000000006806 102.0
SHD1_k127_5057381_16 Acetyltransferase (GNAT) domain - - - 0.00000000000000003944 81.0
SHD1_k127_5057381_2 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 499.0
SHD1_k127_5057381_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 454.0
SHD1_k127_5057381_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 445.0
SHD1_k127_5057381_5 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 364.0
SHD1_k127_5057381_6 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 367.0
SHD1_k127_5057381_7 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 299.0
SHD1_k127_5057381_8 TIGRFAM DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 289.0
SHD1_k127_5057381_9 Protein of unknown function, DUF484 K09921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 284.0
SHD1_k127_5062131_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1379.0
SHD1_k127_5062131_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 329.0
SHD1_k127_5062131_2 Uncharacterized protein conserved in bacteria (DUF2331) - - - 0.00000000000000000000000000000000000000000000000001346 182.0
SHD1_k127_5062131_3 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.00000000000000000000000000000000000000000000000001418 183.0
SHD1_k127_5071101_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 0.0 1495.0
SHD1_k127_5071101_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.0 1062.0
SHD1_k127_5071101_10 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 460.0
SHD1_k127_5071101_11 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 451.0
SHD1_k127_5071101_12 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 379.0
SHD1_k127_5071101_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 346.0
SHD1_k127_5071101_14 SMART ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 339.0
SHD1_k127_5071101_15 response regulator, receiver K02485 - - 0.000000000000000000000000000000000000000000000000000000000000002223 220.0
SHD1_k127_5071101_16 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000004749 236.0
SHD1_k127_5071101_17 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000009318 193.0
SHD1_k127_5071101_18 TIGRFAM succinate dehydrogenase, hydrophobic membrane anchor protein K00242 - - 0.000000000000000000000000000000000000000000004503 171.0
SHD1_k127_5071101_19 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.0000000000000000000000000002936 130.0
SHD1_k127_5071101_2 SMART AAA ATPase K02450 - - 8.333e-253 790.0
SHD1_k127_5071101_21 - - - - 0.000000000000000000000001101 108.0
SHD1_k127_5071101_22 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000000000004177 94.0
SHD1_k127_5071101_23 - - - - 0.0000004301 54.0
SHD1_k127_5071101_24 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000002438 49.0
SHD1_k127_5071101_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 3.576e-252 781.0
SHD1_k127_5071101_4 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 5.707e-194 608.0
SHD1_k127_5071101_5 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 615.0
SHD1_k127_5071101_6 SMART ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 578.0
SHD1_k127_5071101_7 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005565 574.0
SHD1_k127_5071101_8 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 500.0
SHD1_k127_5071101_9 PFAM Alcohol dehydrogenase GroES domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 493.0
SHD1_k127_5075676_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 2.37e-244 759.0
SHD1_k127_5075676_1 PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006259 571.0
SHD1_k127_5075676_2 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 532.0
SHD1_k127_5075676_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 469.0
SHD1_k127_5075676_4 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000003891 156.0
SHD1_k127_5085795_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - 0.0 1098.0
SHD1_k127_5085795_1 metal-dependent phosphohydrolase HD sub domain - - - 2.541e-242 761.0
SHD1_k127_5085795_2 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 4.519e-242 756.0
SHD1_k127_5085795_3 cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 424.0
SHD1_k127_5085795_4 SMART beta-lactamase domain protein K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 415.0
SHD1_k127_5085795_5 Prokaryotic N-terminal methylation motif K02650 - - 0.000000000000421 70.0
SHD1_k127_5095272_0 PFAM type II and III secretion system protein K02453,K12282 - - 2.509e-207 659.0
SHD1_k127_5095272_1 PFAM Type II secretion system F domain K02455,K12278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 497.0
SHD1_k127_5095272_10 general secretion pathway protein K02456,K02457,K02458,K10930,K12285 - - 0.000000000000000000000000000000000000000000000000000008253 194.0
SHD1_k127_5095272_11 Prokaryotic N-terminal methylation motif K10924 - - 0.0000000000000000000000000000000001664 138.0
SHD1_k127_5095272_12 - K12281 - - 0.0000000000000006015 86.0
SHD1_k127_5095272_13 PFAM Type II secretion system F domain K02455,K12278 - - 0.0000000001006 62.0
SHD1_k127_5095272_14 Prokaryotic N-terminal methylation motif - - - 0.000000007829 64.0
SHD1_k127_5095272_15 Prokaryotic N-terminal methylation motif K10926 - - 0.0004502 50.0
SHD1_k127_5095272_16 general secretion pathway protein K02456,K02457,K02458,K02459,K10927 - - 0.0006452 48.0
SHD1_k127_5095272_2 AAA domain K02450,K12283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 475.0
SHD1_k127_5095272_3 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 387.0
SHD1_k127_5095272_4 Pilus assembly protein K12279 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005604 361.0
SHD1_k127_5095272_5 Dinitrogenase reductase K05951 - 2.4.2.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 343.0
SHD1_k127_5095272_6 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000293 278.0
SHD1_k127_5095272_7 Tetratricopeptide repeat K12284 - - 0.000000000000000000000000000000000000000000000000000000000000000008367 242.0
SHD1_k127_5095272_8 Fimbrial assembly protein (PilN) - - - 0.0000000000000000000000000000000000000000000000000000000003876 212.0
SHD1_k127_5095272_9 carbon utilization K12280 - - 0.000000000000000000000000000000000000000000000000000000003385 212.0
SHD1_k127_5134776_0 General secretory system II protein E domain protein K02454,K02652,K12276 - - 8.713e-290 897.0
SHD1_k127_5134776_1 Domain of unknown function (DUF3364) K02591 - 1.18.6.1 6.637e-205 642.0
SHD1_k127_5134776_2 PFAM Type II secretion system F domain K02455,K12278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 600.0
SHD1_k127_5134776_3 ArsC family - - - 0.00000000000000000000000000000000000000000000000004171 181.0
SHD1_k127_5134776_4 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000005965 175.0
SHD1_k127_5134776_5 general secretion pathway protein K02456,K02457,K02458,K10930,K12285 - - 0.000000000000000000000000000004861 122.0
SHD1_k127_5250156_0 TYPE 4 fimbrial BIOGENESIS K02672 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 418.0
SHD1_k127_5250156_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 314.0
SHD1_k127_5250156_2 type IV pilus modification protein PilV K02671 - - 0.000000000000000000000000000000000000000000000000005561 196.0
SHD1_k127_5250156_3 Pilus assembly protein PilX - - - 0.0000000000000000000000000000000000000000000004159 172.0
SHD1_k127_5250156_4 protein transport across the cell outer membrane K08084 - - 0.0000000000000000000000000000000004451 137.0
SHD1_k127_5270697_0 Hsp70 protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.0 1133.0
SHD1_k127_5270697_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007902 566.0
SHD1_k127_5270697_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 319.0
SHD1_k127_5270697_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 297.0
SHD1_k127_5270697_4 ErfK ybiS ycfS ynhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001634 283.0
SHD1_k127_5270697_5 LemA Family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007992 275.0
SHD1_k127_5270697_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001951 271.0
SHD1_k127_5270697_7 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003384 235.0
SHD1_k127_5270697_9 Nucleoside H+ symporter K05820 - - 0.00001017 47.0
SHD1_k127_5411933_0 Outer membrane usher protein K07347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 384.0
SHD1_k127_5411933_1 Binding-protein-dependent transport system inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009908 312.0
SHD1_k127_5411933_10 Spore Coat Protein U domain - - - 0.0000000000000000000000002347 112.0
SHD1_k127_5411933_11 Spore Coat Protein U domain - - - 0.000000000000001028 83.0
SHD1_k127_5411933_2 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 319.0
SHD1_k127_5411933_3 Bacterial extracellular solute-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 299.0
SHD1_k127_5411933_4 PFAM Alpha beta hydrolase K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000000000000000003815 226.0
SHD1_k127_5411933_5 TIGRFAM Molybdenum-pterin binding K02019 - - 0.0000000000000000000000000000000000000000000000007383 179.0
SHD1_k127_5411933_6 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02019 - - 0.000000000000000000000000000000000005085 143.0
SHD1_k127_5411933_8 Protein of unknown function (DUF559) K07316 - 2.1.1.72 0.0000000000000000000000000000008391 126.0
SHD1_k127_5411933_9 assembly chaperone K07346 - - 0.00000000000000000000000000002463 126.0
SHD1_k127_561872_0 MgtE intracellular N domain K06213 - - 4.377e-252 786.0
SHD1_k127_561872_1 Elongator protein 3, MiaB family, Radical SAM - - - 9.98e-248 771.0
SHD1_k127_561872_10 cytochrome b561 K12262 - - 0.00000000000000000000000000003541 125.0
SHD1_k127_561872_11 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000004962 113.0
SHD1_k127_561872_12 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000001215 83.0
SHD1_k127_561872_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 536.0
SHD1_k127_561872_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 473.0
SHD1_k127_561872_4 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 469.0
SHD1_k127_561872_5 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 357.0
SHD1_k127_561872_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 346.0
SHD1_k127_561872_7 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000000000000000000000000000002124 246.0
SHD1_k127_561872_8 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000004791 181.0
SHD1_k127_561872_9 Domain of unknown function (DUF3400) - - - 0.0000000000000000000000000000000000000000000000004328 176.0
SHD1_k127_620606_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0 1045.0
SHD1_k127_620606_1 B12 binding domain - - - 0.0 1028.0
SHD1_k127_620606_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008584 551.0
SHD1_k127_620606_11 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 508.0
SHD1_k127_620606_12 sensor diguanylate cyclase phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 491.0
SHD1_k127_620606_13 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003417 462.0
SHD1_k127_620606_14 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 460.0
SHD1_k127_620606_15 pteridine-dependent deoxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 436.0
SHD1_k127_620606_16 Glycosyl transferase family 2 K00786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 432.0
SHD1_k127_620606_17 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 412.0
SHD1_k127_620606_18 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 396.0
SHD1_k127_620606_19 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 396.0
SHD1_k127_620606_2 MMPL family - - - 0.0 1012.0
SHD1_k127_620606_20 Bacterial lipid A biosynthesis acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 389.0
SHD1_k127_620606_21 MltA-interacting protein MipA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 372.0
SHD1_k127_620606_22 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 365.0
SHD1_k127_620606_23 Beta-ketoacyl synthase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 358.0
SHD1_k127_620606_24 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 337.0
SHD1_k127_620606_25 FMN binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007792 306.0
SHD1_k127_620606_26 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001252 272.0
SHD1_k127_620606_27 MarR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001836 244.0
SHD1_k127_620606_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004505 237.0
SHD1_k127_620606_29 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000006885 219.0
SHD1_k127_620606_3 fad dependent oxidoreductase - - - 1.723e-219 687.0
SHD1_k127_620606_30 - - - - 0.00000000000000000000000000000000000000000000000000000000000003515 221.0
SHD1_k127_620606_31 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000000000000000000000478 214.0
SHD1_k127_620606_32 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000003279 209.0
SHD1_k127_620606_33 dehydratase - - - 0.0000000000000000000000000000000000000000000000000005422 188.0
SHD1_k127_620606_34 OmpA family K03640 - - 0.00000000000000000000000000000000000000000000002406 174.0
SHD1_k127_620606_35 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000000000000000001084 149.0
SHD1_k127_620606_36 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000000000000000004365 143.0
SHD1_k127_620606_37 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000006337 128.0
SHD1_k127_620606_38 FabA-like domain - - - 0.000000000000000000000000005599 113.0
SHD1_k127_620606_39 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000006856 91.0
SHD1_k127_620606_4 Sodium/hydrogen exchanger family - - - 3.521e-214 670.0
SHD1_k127_620606_5 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 6.093e-212 661.0
SHD1_k127_620606_6 Chloride channel - - - 2.965e-210 660.0
SHD1_k127_620606_7 Beta-ketoacyl synthase, C-terminal domain K00647,K09458 - 2.3.1.179,2.3.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 596.0
SHD1_k127_620606_8 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 597.0
SHD1_k127_620606_9 Domain of unknown function (DUF4872) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 562.0
SHD1_k127_639714_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 9.692e-292 912.0
SHD1_k127_639714_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 9.125e-280 872.0
SHD1_k127_639714_10 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 442.0
SHD1_k127_639714_11 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 343.0
SHD1_k127_639714_12 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000000000000000000001381 220.0
SHD1_k127_639714_2 peptidase M24B X-Pro dipeptidase aminopeptidase domain protein K01262 - 3.4.11.9 3.455e-209 661.0
SHD1_k127_639714_3 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 597.0
SHD1_k127_639714_4 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 556.0
SHD1_k127_639714_5 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 539.0
SHD1_k127_639714_6 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 537.0
SHD1_k127_639714_7 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 486.0
SHD1_k127_639714_8 Sodium/hydrogen exchanger family K03316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 457.0
SHD1_k127_639714_9 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 457.0
SHD1_k127_68408_0 DHH family K07462 - - 2.921e-277 862.0
SHD1_k127_68408_1 ACT domain K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 6.252e-234 727.0
SHD1_k127_68408_10 - - - - 0.00000000000000000000000000000000005153 140.0
SHD1_k127_68408_2 - - - - 2.04e-218 683.0
SHD1_k127_68408_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 4.424e-201 629.0
SHD1_k127_68408_4 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 555.0
SHD1_k127_68408_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 421.0
SHD1_k127_68408_6 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 397.0
SHD1_k127_68408_7 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 313.0
SHD1_k127_68408_8 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000005134 201.0
SHD1_k127_68408_9 Domain of unknown function (DUF1987) - - - 0.00000000000000000000000000000000000003007 149.0
SHD1_k127_694717_0 TIGRFAM fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 599.0
SHD1_k127_694717_1 PFAM type II secretion system protein E K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009636 512.0
SHD1_k127_694717_2 LysR substrate binding domain K21703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 458.0
SHD1_k127_694717_3 Belongs to the RuBisCO large chain family K01601 - 4.1.1.39 0.00000000000000000000000000512 110.0
SHD1_k127_708152_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.16e-297 920.0
SHD1_k127_708152_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.04e-270 839.0
SHD1_k127_708152_10 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 415.0
SHD1_k127_708152_11 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 405.0
SHD1_k127_708152_12 water channel activity K02440,K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005808 390.0
SHD1_k127_708152_13 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 371.0
SHD1_k127_708152_14 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 344.0
SHD1_k127_708152_15 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 333.0
SHD1_k127_708152_16 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 330.0
SHD1_k127_708152_17 Part of a membrane complex involved in electron transport K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 317.0
SHD1_k127_708152_18 Protein of unknown function (DUF615) K09889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001357 246.0
SHD1_k127_708152_19 Part of a membrane complex involved in electron transport K03612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009849 259.0
SHD1_k127_708152_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 1.231e-222 697.0
SHD1_k127_708152_20 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000000000000000000000000000000000000000000000000003685 196.0
SHD1_k127_708152_21 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000000000002708 168.0
SHD1_k127_708152_22 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000000000000000000000009675 160.0
SHD1_k127_708152_24 SMART RNA-binding S4 domain protein K04762 - - 0.0000000000000000000000000000000000001847 149.0
SHD1_k127_708152_25 N-ATPase, AtpR subunit - - - 0.000000000000000000002283 98.0
SHD1_k127_708152_3 Part of a membrane complex involved in electron transport K03615 - - 1.393e-204 650.0
SHD1_k127_708152_4 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 550.0
SHD1_k127_708152_5 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 501.0
SHD1_k127_708152_6 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 479.0
SHD1_k127_708152_7 TIGRFAM Polyphosphate nucleotide phosphotransferase, PPK2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 472.0
SHD1_k127_708152_8 PFAM H transporting two-sector ATPase gamma subunit K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 472.0
SHD1_k127_708152_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 459.0
SHD1_k127_711570_0 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 558.0
SHD1_k127_711570_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008388 555.0
SHD1_k127_711570_2 Belongs to the GPI family K01810 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 390.0
SHD1_k127_733948_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 1.719e-294 911.0
SHD1_k127_733948_1 MacB-like periplasmic core domain K02004 - - 4.962e-202 634.0
SHD1_k127_733948_2 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 584.0
SHD1_k127_733948_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 507.0
SHD1_k127_733948_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007799 400.0
SHD1_k127_733948_5 Protein of unknown function (DUF2971) - - - 0.00007437 47.0
SHD1_k127_783246_0 Histidine Phosphotransfer domain - - - 2.005e-215 722.0
SHD1_k127_783246_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 543.0
SHD1_k127_783246_2 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000757 246.0
SHD1_k127_783246_3 Paraquat-inducible protein A - - - 0.00000000000000000000000000000000000000000000000000000000000000000003865 248.0
SHD1_k127_783246_4 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000006537 232.0
SHD1_k127_783246_5 transport system periplasmic component K01989 - - 0.0000000000000000000000000000000000000000000000000000005437 205.0
SHD1_k127_783246_6 PFAM GCN5-related N-acetyltransferase K22441 - 2.3.1.57 0.00000000000000000000000000000000000000000000000000002221 194.0
SHD1_k127_783246_7 NifQ K15790 - - 0.00000000000000000000000000000000001366 136.0
SHD1_k127_783246_8 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.00000000000000000000000000003734 116.0
SHD1_k127_851230_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1080.0
SHD1_k127_851230_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 2.44e-239 743.0
SHD1_k127_851230_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 512.0
SHD1_k127_851230_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 497.0
SHD1_k127_851230_4 Cellulose biosynthesis protein BcsG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 458.0
SHD1_k127_851230_5 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 376.0
SHD1_k127_851230_6 Protein of unknown function (DUF3025) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 339.0
SHD1_k127_851230_7 cellulose synthase operon C domain protein K20543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 296.0
SHD1_k127_851230_8 Haem-degrading - - - 0.0000000000000000000000000000000000000000000000000000000000000000005567 229.0
SHD1_k127_862147_0 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 462.0
SHD1_k127_862147_1 Histidine kinase K20975 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 319.0
SHD1_k127_862147_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001753 252.0
SHD1_k127_862147_3 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000004176 218.0
SHD1_k127_862147_4 PAS domain containing protein - - - 0.00000000000000000000000000000000000000004541 175.0
SHD1_k127_862147_5 C4-dicarboxylate transport sensor protein dctB - - - 0.00000000000000000000000000000000000006294 165.0
SHD1_k127_863136_0 Hypothetical glycosyl hydrolase family 13 K11931 - - 8e-318 985.0
SHD1_k127_863136_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 3.258e-250 776.0
SHD1_k127_863136_10 COG2826 Transposase and inactivated derivatives, IS30 family K07482 - - 0.00000000000001949 72.0
SHD1_k127_863136_2 Glycosyl transferase family 21 K11936 - - 5.526e-239 743.0
SHD1_k127_863136_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 458.0
SHD1_k127_863136_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 461.0
SHD1_k127_863136_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 440.0
SHD1_k127_863136_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K03601,K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 381.0
SHD1_k127_863136_7 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 317.0
SHD1_k127_863136_8 PgaD-like protein K11937 - - 0.00000000000000000000000000000000000000000000000000004222 191.0
SHD1_k127_863136_9 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates - - - 0.0000000000000000003835 89.0
SHD1_k127_874160_0 Domain of unknown function (DUF3400) - - - 0.0 1775.0
SHD1_k127_874160_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 2.703e-217 683.0
SHD1_k127_874160_10 PFAM Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002129 269.0
SHD1_k127_874160_11 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000000001151 233.0
SHD1_k127_874160_12 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.000000000000000000000000000000000000000000000000000007168 195.0
SHD1_k127_874160_13 PFAM sigma 54 modulation protein ribosomal protein S30EA K05808 - - 0.00000000000000000000000000000000000000000004588 162.0
SHD1_k127_874160_14 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0000000000000000000000000003033 123.0
SHD1_k127_874160_15 NusG domain II - - - 0.0000000000008659 75.0
SHD1_k127_874160_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 510.0
SHD1_k127_874160_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 482.0
SHD1_k127_874160_4 P-loop ATPase protein family K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 435.0
SHD1_k127_874160_5 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 429.0
SHD1_k127_874160_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 435.0
SHD1_k127_874160_7 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 381.0
SHD1_k127_874160_8 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 379.0
SHD1_k127_874160_9 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004408 278.0
SHD1_k127_887846_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1028.0
SHD1_k127_887846_1 Large family of predicted nucleotide-binding domains K07175 - - 2.896e-255 794.0
SHD1_k127_887846_10 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000002191 259.0
SHD1_k127_887846_11 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000001257 248.0
SHD1_k127_887846_12 Belongs to the MsrB Met sulfoxide reductase family K07305,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000004908 229.0
SHD1_k127_887846_13 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000001547 246.0
SHD1_k127_887846_14 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000209 226.0
SHD1_k127_887846_15 phospholipase K01058 - 3.1.1.32,3.1.1.4 0.00000000000000000000000000000000000000000000000000002067 200.0
SHD1_k127_887846_16 Bacterial Ig-like domain 2 - - - 0.0000000000000000000000000000000000000000000005124 188.0
SHD1_k127_887846_17 KTSC domain - - - 0.00000000000000000000000000000000000000000007247 162.0
SHD1_k127_887846_18 YCII-related domain K09780 - - 0.000000000000000000000000000000000000000006466 155.0
SHD1_k127_887846_19 BolA-like protein K05527 - - 0.00000000000000000000002371 107.0
SHD1_k127_887846_2 histidine kinase A domain protein - - - 7.455e-208 663.0
SHD1_k127_887846_20 Belongs to the glycosyl hydrolase family 6 K19668 - 3.2.1.91 0.00000000004269 76.0
SHD1_k127_887846_21 ABC transporter transmembrane region K06147 - - 0.0004424 45.0
SHD1_k127_887846_3 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 524.0
SHD1_k127_887846_4 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 435.0
SHD1_k127_887846_5 Papain cysteine protease family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 393.0
SHD1_k127_887846_6 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 346.0
SHD1_k127_887846_7 Intracellular septation protein A K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002054 276.0
SHD1_k127_887846_8 Lipase (class 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000204 279.0
SHD1_k127_887846_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001389 265.0
SHD1_k127_899077_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1032.0
SHD1_k127_899077_1 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 3.206e-272 852.0
SHD1_k127_899077_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 443.0
SHD1_k127_899077_3 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 325.0
SHD1_k127_899077_4 Thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 298.0
SHD1_k127_899077_5 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 293.0
SHD1_k127_899077_6 PFAM cytochrome c class I K08738 - - 0.0000000000000000000000000000000000000008021 151.0
SHD1_k127_899077_8 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000001309 85.0
SHD1_k127_899077_9 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000004723 74.0
SHD1_k127_942080_0 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 2.676e-278 869.0
SHD1_k127_942080_1 PFAM aminotransferase class I and II K14260 - 2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 553.0
SHD1_k127_942080_2 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 422.0
SHD1_k127_942080_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 369.0
SHD1_k127_942080_4 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 367.0
SHD1_k127_942080_5 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005322 276.0
SHD1_k127_942080_6 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006266 254.0
SHD1_k127_942080_7 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000000000000000000000000000001835 173.0
SHD1_k127_942080_8 - - - - 0.00000000000004392 76.0
SHD1_k127_961007_0 PFAM ABC transporter related - - - 0.0 1024.0
SHD1_k127_961007_1 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 524.0
SHD1_k127_961007_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 376.0
SHD1_k127_961007_3 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000001059 179.0
SHD1_k127_961007_4 mRNA binding - - - 0.0000000000000000000000000000003057 122.0
SHD1_k127_961007_5 Transposase IS200 like - - - 0.00000000000000000002333 91.0
SHD1_k127_961555_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.703e-306 942.0
SHD1_k127_961555_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 473.0
SHD1_k127_961555_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 469.0
SHD1_k127_961555_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 415.0
SHD1_k127_961555_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 402.0
SHD1_k127_961555_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000000000000000000000000000007632 228.0
SHD1_k127_961555_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000000000000000000000003049 222.0
SHD1_k127_961555_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000000009372 138.0
SHD1_k127_961555_8 ATP synthase I chain K02116 - - 0.00000003487 59.0
SHD1_k127_971269_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1153.0
SHD1_k127_971269_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1117.0
SHD1_k127_971269_10 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 332.0
SHD1_k127_971269_11 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 289.0
SHD1_k127_971269_12 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 278.0
SHD1_k127_971269_13 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004909 242.0
SHD1_k127_971269_14 Uracil DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000306 234.0
SHD1_k127_971269_15 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000000000000000000000006962 228.0
SHD1_k127_971269_16 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000000000000000004923 186.0
SHD1_k127_971269_17 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000000000174 157.0
SHD1_k127_971269_19 Molybdopterin oxidoreductase Fe4S4 domain K02567 - - 0.000000000000000000007743 94.0
SHD1_k127_971269_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.332e-289 899.0
SHD1_k127_971269_20 - - - - 0.00000000000432 70.0
SHD1_k127_971269_21 - - - - 0.000000004265 57.0
SHD1_k127_971269_3 Participates in both transcription termination and antitermination K02600 - - 2.826e-272 842.0
SHD1_k127_971269_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772,K03815 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 516.0
SHD1_k127_971269_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 433.0
SHD1_k127_971269_6 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 417.0
SHD1_k127_971269_7 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 369.0
SHD1_k127_971269_8 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 331.0
SHD1_k127_971269_9 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003999,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0012505,GO:0016192,GO:0016208,GO:0016740,GO:0016757,GO:0016763,GO:0017076,GO:0018130,GO:0019438,GO:0030141,GO:0030554,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0043094,GO:0043101,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046483,GO:0046903,GO:0050896,GO:0051179,GO:0051234,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 318.0