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Overview

ID MAG03370
Name SHD2_bin.10
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Gallionellaceae
Genus
Species
Assembly information
Completeness (%) 73.62
Contamination (%) 1.95
GC content (%) 59.0
N50 (bp) 8,554
Genome size (bp) 2,103,387

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2252

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1102442_0 Thiolase, C-terminal domain K00632 - 2.3.1.16 3.236e-220 687.0
SHD2_k127_1102442_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 329.0
SHD2_k127_1102442_2 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.000000000000000000000000000000000000000000000000000000000005198 211.0
SHD2_k127_1102442_3 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000000000000000000000000000006001 203.0
SHD2_k127_1102442_4 pathogenesis - - - 0.000000000000000000005694 101.0
SHD2_k127_1102442_5 nucleotidyltransferase domain K07075 - - 0.000000000000001781 79.0
SHD2_k127_1114526_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1226.0
SHD2_k127_1114526_1 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 380.0
SHD2_k127_1114526_2 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 366.0
SHD2_k127_1120695_0 Proton-conducting membrane transporter - - - 1.574e-300 934.0
SHD2_k127_1120695_1 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006442 279.0
SHD2_k127_1126757_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 370.0
SHD2_k127_1126757_1 PFAM DNA polymerase III chi subunit HolC K02339 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000008335 234.0
SHD2_k127_1144447_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 0.0 1497.0
SHD2_k127_1144447_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 0.0 1062.0
SHD2_k127_1144447_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 3.576e-252 781.0
SHD2_k127_1144447_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 5.707e-194 608.0
SHD2_k127_1144447_4 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 500.0
SHD2_k127_1144447_5 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 451.0
SHD2_k127_1144447_6 TIGRFAM succinate dehydrogenase, hydrophobic membrane anchor protein K00242 - - 0.0000000000000000000000000000000000000000000008631 170.0
SHD2_k127_1144447_7 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.0000000000000000000000000003938 129.0
SHD2_k127_1144447_8 Flavinator of succinate dehydrogenase K09159 - - 0.0000000000000000002024 92.0
SHD2_k127_1144447_9 - - - - 0.0000001912 53.0
SHD2_k127_1149800_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 591.0
SHD2_k127_1149800_1 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 462.0
SHD2_k127_1149800_2 Threonyl and Alanyl tRNA synthetase second additional domain K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000008513 214.0
SHD2_k127_1162100_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 2.014e-264 820.0
SHD2_k127_1162100_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 3.6e-226 707.0
SHD2_k127_1162100_10 - - - - 0.000000000000001145 78.0
SHD2_k127_1162100_2 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 398.0
SHD2_k127_1162100_3 Glutathione S-transferase, C-terminal domain K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 365.0
SHD2_k127_1162100_4 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 355.0
SHD2_k127_1162100_5 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 294.0
SHD2_k127_1162100_6 Stringent starvation protein B K03600 - - 0.000000000000000000000000000000000000000000000004291 178.0
SHD2_k127_1162100_7 - - - - 0.0000000000000000000000000000000000000000000001834 170.0
SHD2_k127_1162100_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000007011 154.0
SHD2_k127_1162100_9 Pfam Polysulphide reductase, NrfD - - - 0.000000000000000000000000000001669 122.0
SHD2_k127_1178584_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000611 559.0
SHD2_k127_1178584_1 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 463.0
SHD2_k127_1178584_2 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 347.0
SHD2_k127_1178584_3 Virulence factor BrkB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 333.0
SHD2_k127_1178584_4 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 335.0
SHD2_k127_1178584_5 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000001102 219.0
SHD2_k127_1178584_8 - - - - 0.000000009691 56.0
SHD2_k127_1222936_0 DEAD DEAH box helicase domain protein K03654 - 3.6.4.12 0.0 1098.0
SHD2_k127_1222936_1 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 533.0
SHD2_k127_1222936_10 - - - - 0.000000000000000000000000000000000000000000000000002245 189.0
SHD2_k127_1222936_11 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000000000000123 181.0
SHD2_k127_1222936_12 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000006178 163.0
SHD2_k127_1222936_13 Uncharacterized ACR, COG1993 - - - 0.00000000000000000000000000000000001185 138.0
SHD2_k127_1222936_2 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 499.0
SHD2_k127_1222936_3 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 435.0
SHD2_k127_1222936_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 425.0
SHD2_k127_1222936_5 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 346.0
SHD2_k127_1222936_6 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 341.0
SHD2_k127_1222936_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 332.0
SHD2_k127_1222936_9 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000000000000000000008994 208.0
SHD2_k127_1234554_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 5.138e-269 837.0
SHD2_k127_1234554_1 Carbon starvation protein CstA K06200 - - 3.749e-240 747.0
SHD2_k127_1234554_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000004204 160.0
SHD2_k127_1234554_3 Ribosomal protein L31 K02909 - - 0.00000000000000000000000000000000000006802 147.0
SHD2_k127_1234554_5 Selenoprotein, putative - - - 0.00000000000006527 74.0
SHD2_k127_1256586_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.0 1303.0
SHD2_k127_1256586_1 Belongs to the UPF0235 family K09131 - - 0.00000000000000000000000000000000000000000001357 168.0
SHD2_k127_1256586_2 Putative quorum-sensing-regulated virulence factor K09954 - - 0.00000000000000000000000000000000001504 136.0
SHD2_k127_1256586_3 Putative quorum-sensing-regulated virulence factor K09954 - - 0.000000000000000000000000000000002827 131.0
SHD2_k127_1256586_4 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000001889 81.0
SHD2_k127_1256586_5 Putative quorum-sensing-regulated virulence factor K09954 - - 0.00003934 46.0
SHD2_k127_1256586_6 Protein of unknown function (DUF3617) - - - 0.0003606 51.0
SHD2_k127_1267231_0 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 454.0
SHD2_k127_1267231_1 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 406.0
SHD2_k127_1267231_2 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004563 278.0
SHD2_k127_1267231_3 COG0714 MoxR-like ATPases K03924 - - 0.0000000000000000000000000000000000000000000000003988 179.0
SHD2_k127_1267231_4 Domain of unknown function (DUF4381) - - - 0.000000000000000000000000004204 117.0
SHD2_k127_1291044_0 Sugar (and other) transporter - - - 3.856e-209 655.0
SHD2_k127_1291044_1 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000818 178.0
SHD2_k127_1291044_2 ethyl tert-butyl ether degradation - - - 0.00000000000000000000000000000000000000007155 153.0
SHD2_k127_1298864_0 Branched-chain amino acid ATP-binding cassette transporter K01995,K11962 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 347.0
SHD2_k127_1298864_1 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 287.0
SHD2_k127_1298864_2 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000001014 162.0
SHD2_k127_1298864_3 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000217 142.0
SHD2_k127_1299199_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 8.024e-263 817.0
SHD2_k127_1299199_1 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 304.0
SHD2_k127_1318521_0 TIGRFAM ATP-dependent Clp protease ATP-binding subunit clpA K03694 - - 0.0 1026.0
SHD2_k127_1318521_1 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000405 160.0
SHD2_k127_1318521_2 SMART Cold shock protein K03704 - - 0.000000000000000000000000006363 112.0
SHD2_k127_1325469_0 secreted hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 521.0
SHD2_k127_1325469_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 465.0
SHD2_k127_1325469_2 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014,K16089 - - 0.000000000000000000000000000000000000000000000000162 186.0
SHD2_k127_132795_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.479e-300 925.0
SHD2_k127_132795_1 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 2.805e-249 781.0
SHD2_k127_132795_10 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000007136 156.0
SHD2_k127_132795_11 - - - - 0.000000000000000000000000000000000000621 149.0
SHD2_k127_132795_13 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000135 91.0
SHD2_k127_132795_14 TfoX N-terminal domain K07343 - - 0.00006946 49.0
SHD2_k127_132795_2 NADH flavin oxidoreductase NADH oxidase K10680 - - 9.912e-194 610.0
SHD2_k127_132795_3 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 587.0
SHD2_k127_132795_4 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 507.0
SHD2_k127_132795_5 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 460.0
SHD2_k127_132795_6 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 404.0
SHD2_k127_132795_7 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 398.0
SHD2_k127_132795_8 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000008163 237.0
SHD2_k127_132795_9 E-Z type HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000002092 225.0
SHD2_k127_1328086_0 nitrite sulfite reductase hemoprotein beta-component ferrodoxin domain protein K00381,K00392 - 1.8.1.2,1.8.7.1 8.186e-306 951.0
SHD2_k127_1328086_1 Elongation factor Tu GTP binding domain K00956 - 2.7.7.4 2.414e-249 772.0
SHD2_k127_1328086_2 Phosphoadenosine phosphosulfate reductase family K00957 - 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 577.0
SHD2_k127_1328086_3 LysR substrate binding domain K13634 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 511.0
SHD2_k127_1328086_4 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 365.0
SHD2_k127_1328086_5 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 353.0
SHD2_k127_1328086_6 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000001 138.0
SHD2_k127_1328086_7 Plasmid maintenance system killer protein K07334 - - 0.00000000000000000000000000000000002165 136.0
SHD2_k127_1328086_8 Belongs to the 'phage' integrase family - - - 0.00000002883 59.0
SHD2_k127_1343969_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1391.0
SHD2_k127_1343969_1 TIGRFAM cytochrome c-type biogenesis protein CcmF K02198 - - 0.0 1099.0
SHD2_k127_1343969_10 PFAM Alcohol dehydrogenase GroES domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 494.0
SHD2_k127_1343969_11 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 457.0
SHD2_k127_1343969_12 FIST_C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 456.0
SHD2_k127_1343969_13 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 428.0
SHD2_k127_1343969_14 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 451.0
SHD2_k127_1343969_15 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 358.0
SHD2_k127_1343969_16 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 353.0
SHD2_k127_1343969_17 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 337.0
SHD2_k127_1343969_18 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 325.0
SHD2_k127_1343969_19 TIGRFAM periplasmic protein thiol disulphide oxidoreductase DsbE K02199 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 297.0
SHD2_k127_1343969_2 SurA N-terminal domain K03770 - 5.2.1.8 3.999e-245 771.0
SHD2_k127_1343969_20 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000000000000000000001703 218.0
SHD2_k127_1343969_21 Cytochrome C biogenesis protein K02200 - - 0.0000000000000000000000000000000000000000000000000000000000003333 214.0
SHD2_k127_1343969_22 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000000000000000001347 152.0
SHD2_k127_1343969_23 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000001024 91.0
SHD2_k127_1343969_24 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.00000000000001318 74.0
SHD2_k127_1343969_26 - - - - 0.0000004301 54.0
SHD2_k127_1343969_27 - - - - 0.00002161 46.0
SHD2_k127_1343969_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 1.062e-231 721.0
SHD2_k127_1343969_4 PFAM aminotransferase class I and II K00812 - 2.6.1.1 6.48e-228 709.0
SHD2_k127_1343969_5 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.708e-204 643.0
SHD2_k127_1343969_6 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 616.0
SHD2_k127_1343969_7 hydroxypyruvate reductase K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 603.0
SHD2_k127_1343969_8 PAC sensor-containing diguanylate cyclase phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 561.0
SHD2_k127_1343969_9 TIGRFAM cytochrome c-type biogenesis protein CcmI K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 525.0
SHD2_k127_1346553_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 3.152e-265 821.0
SHD2_k127_1346553_1 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 1.097e-238 744.0
SHD2_k127_1346553_2 PFAM outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000006627 224.0
SHD2_k127_1346553_3 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000000000008101 161.0
SHD2_k127_1390706_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 523.0
SHD2_k127_1390706_1 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009947 440.0
SHD2_k127_1390706_2 Acyl-CoA dehydrogenase, N-terminal domain K06445 - - 0.000006587 48.0
SHD2_k127_140252_0 PFAM peptidase S1 and S6 chymotrypsin Hap K04691,K04772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002891 590.0
SHD2_k127_140252_1 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 399.0
SHD2_k127_140252_2 4 iron, 4 sulfur cluster binding K02574 - - 0.00000000000000000000000000000000000000000000000000000001348 199.0
SHD2_k127_1449936_0 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 510.0
SHD2_k127_1449936_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008933 239.0
SHD2_k127_1449936_2 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000000001987 192.0
SHD2_k127_1467071_0 general secretion pathway protein K K02460 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 311.0
SHD2_k127_1467071_1 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003425 280.0
SHD2_k127_1467071_10 general secretion pathway protein K02457 - - 0.00000000000000003678 88.0
SHD2_k127_1467071_11 ig-like, plexins, transcription factors - - - 0.0000000001646 71.0
SHD2_k127_1467071_12 antisigma factor binding K04749 - - 0.00000004563 59.0
SHD2_k127_1467071_2 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001907 267.0
SHD2_k127_1467071_3 general secretion pathway protein G K02456 - - 0.00000000000000000000000000000000000000000000000000000000000000000009256 233.0
SHD2_k127_1467071_4 General secretion pathway protein K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.0000000000000000000000000000000000000000000002571 174.0
SHD2_k127_1467071_5 General secretion pathway protein I K02458 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.00000000000000000000000000000000002716 139.0
SHD2_k127_1467071_6 General secretion pathway K02462 - - 0.00000000000000000000000000002451 123.0
SHD2_k127_1467071_7 AraC-binding-like domain - - - 0.00000000000000000000000000002625 130.0
SHD2_k127_1484374_0 Threonine synthase N terminus K01733 - 4.2.3.1 6.755e-288 888.0
SHD2_k127_1484374_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 600.0
SHD2_k127_1484374_2 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 492.0
SHD2_k127_1484374_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002645 247.0
SHD2_k127_1484374_4 Domain of unknown function (DUF1956) - - - 0.00000000000000000000000000000000000000000000000000000000000000008692 224.0
SHD2_k127_1484374_5 Endonuclease containing a URI domain K07461 - - 0.0000000000000000000000000000000000000001704 152.0
SHD2_k127_1484374_6 Cupin domain - - - 0.000000000000000003133 88.0
SHD2_k127_1508845_0 AAA domain, putative AbiEii toxin, Type IV TA system K06926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 546.0
SHD2_k127_1508845_1 RloB-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001752 271.0
SHD2_k127_1508845_2 AsmA family K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006857 244.0
SHD2_k127_1508845_3 surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000005738 228.0
SHD2_k127_1508845_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000007505 138.0
SHD2_k127_1508845_5 positive regulation of growth - - - 0.0000000000000000001182 91.0
SHD2_k127_1508845_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00002591 50.0
SHD2_k127_1528088_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 4.388e-284 879.0
SHD2_k127_1528088_1 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000000000000000000000000000001751 240.0
SHD2_k127_1528088_2 TIGRFAM iron-sulfur cluster assembly protein IscA K13628 - - 0.000000000000000000000000000000000000000000000000000000008458 198.0
SHD2_k127_1528088_3 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000004338 87.0
SHD2_k127_156032_0 MscS Mechanosensitive ion channel - - - 2.731e-237 743.0
SHD2_k127_156032_1 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 2.38e-198 631.0
SHD2_k127_156032_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 551.0
SHD2_k127_156032_3 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005384 282.0
SHD2_k127_156032_4 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000133 98.0
SHD2_k127_1563822_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1414.0
SHD2_k127_1563822_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 6.117e-238 738.0
SHD2_k127_1563822_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 466.0
SHD2_k127_1563822_3 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 421.0
SHD2_k127_1563822_4 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 325.0
SHD2_k127_1563822_5 Abortive infection C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000435 215.0
SHD2_k127_1563822_6 Transcriptional regulator K13643 - - 0.000000000000000000000000000000000000000000000000000000000004152 211.0
SHD2_k127_1563822_7 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000005552 138.0
SHD2_k127_1563822_8 regulator K18831 - - 0.0000000000000000000000000000000963 128.0
SHD2_k127_1563822_9 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system K19166 - - 0.000000000000000000001341 97.0
SHD2_k127_1567670_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 1194.0
SHD2_k127_1567670_1 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009838 571.0
SHD2_k127_1567670_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 348.0
SHD2_k127_1567670_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002497 257.0
SHD2_k127_1567670_4 Prokaryotic N-terminal methylation motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008252 257.0
SHD2_k127_1567670_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000272 155.0
SHD2_k127_1626210_0 Transposase - - - 1.251e-195 614.0
SHD2_k127_1626210_1 Transposase K07487 - - 0.00000000004635 69.0
SHD2_k127_1636759_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 2.446e-250 775.0
SHD2_k127_1636759_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007915 509.0
SHD2_k127_1636759_2 DAHP synthetase I family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 504.0
SHD2_k127_1728612_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.0 1951.0
SHD2_k127_1728612_1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 334.0
SHD2_k127_1728612_2 Protein of unknown function (DUF2937) - - - 0.00000000000000000000000000000000000000000000000000000000000000001257 228.0
SHD2_k127_1728612_3 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.00000000000000000000000003399 110.0
SHD2_k127_1728612_4 - - - - 0.0007364 48.0
SHD2_k127_1742581_0 peptidase M24B X-Pro dipeptidase aminopeptidase domain protein K01262 - 3.4.11.9 3.455e-209 661.0
SHD2_k127_1742581_1 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006523 537.0
SHD2_k127_1742581_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 486.0
SHD2_k127_1742581_3 Sodium/hydrogen exchanger family K03316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 457.0
SHD2_k127_1742581_4 Domain of unknown function (DUF389) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 457.0
SHD2_k127_1742581_5 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 343.0
SHD2_k127_1742581_6 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000001322 252.0
SHD2_k127_1742581_7 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000000000000000000001381 220.0
SHD2_k127_1742581_8 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000008636 170.0
SHD2_k127_1789511_0 PFAM polysaccharide biosynthesis protein CapD - - - 4.008e-218 683.0
SHD2_k127_1789511_1 Glycosyltransferase Family 4 K02844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 482.0
SHD2_k127_1789511_2 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 316.0
SHD2_k127_1789511_3 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 306.0
SHD2_k127_1789511_4 O-Antigen ligase K02847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 293.0
SHD2_k127_1817664_0 COG0474 Cation transport ATPase K01531 - 3.6.3.2 0.0 1396.0
SHD2_k127_1817664_1 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 520.0
SHD2_k127_1817664_2 histidine kinase HAMP region domain protein K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 362.0
SHD2_k127_1817664_3 response regulator K02483,K07666,K07774 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001049 262.0
SHD2_k127_1817664_4 Phosphorylase superfamily K00772,K03815 - 2.4.2.28 0.0000000000000000000000000000000000000000002487 162.0
SHD2_k127_1831605_0 Neisseria PilC beta-propeller domain K02674 - - 0.0 1483.0
SHD2_k127_1831605_1 Major Facilitator - - - 4.268e-225 704.0
SHD2_k127_1831605_10 Histidine kinase K11617 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000002857 252.0
SHD2_k127_1831605_11 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.0000000000000000000000000000000000000000000000000000000000000004358 220.0
SHD2_k127_1831605_12 type IV pilus modification protein PilV K02671 - - 0.000000000000000000000000000000000000000000000000004085 196.0
SHD2_k127_1831605_13 Histidine kinase-like ATPase domain - - - 0.0000000000000000000000000000000000000000000000003911 185.0
SHD2_k127_1831605_14 Pilus assembly protein PilX - - - 0.00000000000000000000000000000000000000000000001361 177.0
SHD2_k127_1831605_15 DsrE/DsrF-like family K06039 - - 0.00000000000000000000000000000000000000000000004966 172.0
SHD2_k127_1831605_16 diol metabolic process K01724 - 4.2.1.96 0.00000000000000000000000000000000000000000000008899 171.0
SHD2_k127_1831605_17 - - - - 0.000000000000000000000000000000000000000003614 164.0
SHD2_k127_1831605_18 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.00000000000000000000000000000000000001649 158.0
SHD2_k127_1831605_19 protein transport across the cell outer membrane K08084 - - 0.0000000000000000000000000000000001733 138.0
SHD2_k127_1831605_2 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 579.0
SHD2_k127_1831605_20 TPM domain K06872 - - 0.0000000000000000000000000004335 127.0
SHD2_k127_1831605_21 cytochrome - - - 0.000000000000000000000000006367 114.0
SHD2_k127_1831605_22 - - - - 0.0000000000000000000000000691 112.0
SHD2_k127_1831605_23 Mitomycin resistance protein K07343 - - 0.000000000000000000000099 99.0
SHD2_k127_1831605_24 Domain of unknown function (DUF4034) - - - 0.000000000000000000008362 105.0
SHD2_k127_1831605_25 Histidine kinase-, DNA gyrase B-, and HSP90-like K11527 - 2.7.13.3 0.000000001259 71.0
SHD2_k127_1831605_26 Sel1-like repeats. K07126 - - 0.00000746 58.0
SHD2_k127_1831605_27 Mitomycin resistance protein K07343 - - 0.00006735 46.0
SHD2_k127_1831605_3 TYPE 4 fimbrial BIOGENESIS K02672 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 418.0
SHD2_k127_1831605_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 412.0
SHD2_k127_1831605_5 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 392.0
SHD2_k127_1831605_6 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008872 374.0
SHD2_k127_1831605_7 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 314.0
SHD2_k127_1831605_8 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003268 281.0
SHD2_k127_1831605_9 PFAM Activator of Hsp90 ATPase 1 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000007412 238.0
SHD2_k127_183707_0 DHH family K07462 - - 4.001e-277 862.0
SHD2_k127_183707_1 ACT domain K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 4.563e-234 727.0
SHD2_k127_183707_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 4.424e-201 629.0
SHD2_k127_183707_3 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 555.0
SHD2_k127_183707_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 416.0
SHD2_k127_183707_5 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 313.0
SHD2_k127_183707_6 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000002012 202.0
SHD2_k127_183707_7 Domain of unknown function (DUF1987) - - - 0.00000000000000000000000000000000000003007 149.0
SHD2_k127_183707_8 - - - - 0.00000000000000000000000000000000005153 140.0
SHD2_k127_183707_9 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000007311 121.0
SHD2_k127_186871_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008794 353.0
SHD2_k127_186871_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 340.0
SHD2_k127_186871_2 PFAM TrkA-N domain protein K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000782 238.0
SHD2_k127_186871_3 Phytochelatin synthase - - - 0.00000000000000000001302 102.0
SHD2_k127_1911006_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 8.251e-231 717.0
SHD2_k127_1911006_1 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 335.0
SHD2_k127_1911006_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000009201 65.0
SHD2_k127_191335_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1603.0
SHD2_k127_191335_1 May be involved in recombinational repair of damaged DNA K03631 - - 3.37e-252 794.0
SHD2_k127_191335_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000000000000000142 127.0
SHD2_k127_191335_2 Neisseria PilC beta-propeller domain K02674 - - 3.078e-213 707.0
SHD2_k127_191335_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 501.0
SHD2_k127_191335_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 455.0
SHD2_k127_191335_5 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 416.0
SHD2_k127_191335_6 Winged helix-turn-helix transcription repressor, HrcA DNA-binding K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 397.0
SHD2_k127_191335_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 396.0
SHD2_k127_191335_8 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000004508 205.0
SHD2_k127_191335_9 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000000000003043 189.0
SHD2_k127_1924717_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.394e-291 901.0
SHD2_k127_1924717_1 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 295.0
SHD2_k127_1924717_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004144 267.0
SHD2_k127_1924717_3 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001181 243.0
SHD2_k127_1924717_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000009196 153.0
SHD2_k127_194707_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 481.0
SHD2_k127_194707_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008584 418.0
SHD2_k127_194707_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 387.0
SHD2_k127_194707_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 335.0
SHD2_k127_194707_4 Domain of unknown function (DUF4845) - - - 0.0000009189 52.0
SHD2_k127_2019938_0 CobB/CobQ-like glutamine amidotransferase domain K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007528 552.0
SHD2_k127_2019938_1 precorrin-6y C5,15-methyltransferase K00595,K02191 - 2.1.1.132,2.1.1.196 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 546.0
SHD2_k127_2019938_10 Nitroreductase family K02303,K04719 - 1.13.11.79,2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 295.0
SHD2_k127_2019938_11 cobalt transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000342 244.0
SHD2_k127_2019938_12 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.000000000000000000000000000000000001358 142.0
SHD2_k127_2019938_13 Cell division protein ZapA K09888 - - 0.0000000000000000001014 89.0
SHD2_k127_2019938_14 - - - - 0.0000000000008206 70.0
SHD2_k127_2019938_15 cobalt transporter - - - 0.00000003467 60.0
SHD2_k127_2019938_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 509.0
SHD2_k127_2019938_3 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009544 472.0
SHD2_k127_2019938_4 PFAM cobalamin (vitamin B12) biosynthesis CbiX K03795 - 4.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 404.0
SHD2_k127_2019938_5 Belongs to the precorrin methyltransferase family K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 402.0
SHD2_k127_2019938_6 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 373.0
SHD2_k127_2019938_7 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 357.0
SHD2_k127_2019938_8 Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 349.0
SHD2_k127_2019938_9 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 293.0
SHD2_k127_2114060_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1218.0
SHD2_k127_2114060_1 Polysulphide reductase, NrfD K00185 - - 1.963e-280 864.0
SHD2_k127_2114060_2 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 541.0
SHD2_k127_2114060_3 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 411.0
SHD2_k127_2114060_4 Belongs to the GbsR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 371.0
SHD2_k127_2114060_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 294.0
SHD2_k127_2114060_6 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000007127 248.0
SHD2_k127_2117459_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.494e-298 923.0
SHD2_k127_2117459_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.056e-217 677.0
SHD2_k127_2117459_10 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.000000000000003412 77.0
SHD2_k127_2117459_2 TIGRFAM Polyphosphate nucleotide phosphotransferase, PPK2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 477.0
SHD2_k127_2117459_3 PFAM H transporting two-sector ATPase gamma subunit K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 475.0
SHD2_k127_2117459_4 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 415.0
SHD2_k127_2117459_5 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 405.0
SHD2_k127_2117459_6 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000000000000000000000000000000000000000000000000003685 196.0
SHD2_k127_2117459_7 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000000000002708 168.0
SHD2_k127_2117459_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000000000000000000000009675 160.0
SHD2_k127_2117459_9 N-ATPase, AtpR subunit - - - 0.000000000000000000002283 98.0
SHD2_k127_214406_0 Outer membrane usher protein K07347 - - 7.248e-230 736.0
SHD2_k127_214406_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 533.0
SHD2_k127_214406_10 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.00000000000000000000000000000000000000000000000000000000000000001582 232.0
SHD2_k127_214406_11 Membrane protein implicated in regulation of membrane protease activity - - - 0.0000000000000000000000000000000008301 146.0
SHD2_k127_214406_12 Acyl carrier protein phosphodiesterase - - - 0.000000000000000000000000000000009082 127.0
SHD2_k127_214406_13 Belongs to the UPF0250 family K09158 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000001351 79.0
SHD2_k127_214406_14 Spore Coat Protein U domain - - - 0.00001012 54.0
SHD2_k127_214406_2 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 486.0
SHD2_k127_214406_3 PFAM aminotransferase class IV K00824 - 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 475.0
SHD2_k127_214406_4 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 426.0
SHD2_k127_214406_5 PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase 1 K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 426.0
SHD2_k127_214406_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 380.0
SHD2_k127_214406_7 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 321.0
SHD2_k127_214406_8 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 291.0
SHD2_k127_214406_9 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07661 - - 0.00000000000000000000000000000000000000000000000000000000000000000004626 240.0
SHD2_k127_2199256_0 SMC domain protein - - - 0.0 1242.0
SHD2_k127_2199256_1 PFAM tRNA synthetase class II (D K and N) K04567 - 6.1.1.6 9.961e-281 868.0
SHD2_k127_2199256_2 Protein of unknown function C-terminus (DUF2399) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003505 267.0
SHD2_k127_2199256_3 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.00000000447 64.0
SHD2_k127_2211202_0 Polyprenyl synthetase K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008926 501.0
SHD2_k127_2211202_1 PFAM Carbon starvation protein CstA K06200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007094 466.0
SHD2_k127_2211202_2 cytochrome - - - 0.000000000000000000000000000000000000001655 153.0
SHD2_k127_2211202_3 - - - - 0.0003617 44.0
SHD2_k127_2231152_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0 1095.0
SHD2_k127_2231152_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 2.515e-279 863.0
SHD2_k127_2231152_10 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001518 280.0
SHD2_k127_2231152_11 TIGRFAM outer membrane autotransporter barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004925 277.0
SHD2_k127_2231152_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000000000000000000008959 167.0
SHD2_k127_2231152_2 TIGRFAM outer membrane autotransporter barrel domain protein - - - 2.625e-268 880.0
SHD2_k127_2231152_3 Ammonium Transporter Family K03320,K06580 - - 1.195e-243 754.0
SHD2_k127_2231152_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 3.472e-237 741.0
SHD2_k127_2231152_5 - - - - 5.531e-237 757.0
SHD2_k127_2231152_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 325.0
SHD2_k127_2231152_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 310.0
SHD2_k127_2231152_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 311.0
SHD2_k127_2231152_9 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 290.0
SHD2_k127_2249355_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1386.0
SHD2_k127_2249355_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1244.0
SHD2_k127_2249355_10 Ppx GppA phosphatase - - - 0.00000000000000000000000000000000000000206 153.0
SHD2_k127_2249355_11 - - - - 0.0000000000000000000000000000000002521 141.0
SHD2_k127_2249355_12 - - - - 0.0000000000000000000000000000001006 130.0
SHD2_k127_2249355_13 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000000000000000000000002266 117.0
SHD2_k127_2249355_14 YCII-related domain K09780 - - 0.0000000000000000000000008377 106.0
SHD2_k127_2249355_15 Copper binding periplasmic protein CusF K07810 - - 0.00000000000006116 76.0
SHD2_k127_2249355_2 TIGRFAM heavy metal efflux pump, CzcA family K07787 - - 3.856e-294 910.0
SHD2_k127_2249355_3 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 3.743e-278 864.0
SHD2_k127_2249355_4 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 410.0
SHD2_k127_2249355_5 Phytochelatin synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002705 253.0
SHD2_k127_2249355_7 Protein of unknown function (DUF3037) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001927 247.0
SHD2_k127_2249355_8 - - - - 0.000000000000000000000000000000000000000000000000000000001101 205.0
SHD2_k127_2249355_9 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000000000000000000000000003304 194.0
SHD2_k127_2250787_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 8.964e-248 768.0
SHD2_k127_2250787_1 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000158 291.0
SHD2_k127_2250787_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000001631 222.0
SHD2_k127_2254323_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 6.093e-212 661.0
SHD2_k127_2254323_1 FMN binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 291.0
SHD2_k127_2254323_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004505 237.0
SHD2_k127_2254323_3 Domain of unknown function (DUF4872) - - - 0.000000000000000000000000000000000000000000000000000000000374 208.0
SHD2_k127_2256082_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1642.0
SHD2_k127_2256082_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 443.0
SHD2_k127_2256082_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 399.0
SHD2_k127_2256082_3 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 324.0
SHD2_k127_2256082_4 Domain of unknown function (DUF1956) - - - 0.000000000000000000000000000000000000000000000000000000000000000000438 230.0
SHD2_k127_2256082_5 PFAM cytochrome c class I K08738 - - 0.0000000000000000000000000000000000000008021 151.0
SHD2_k127_2256082_7 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000001309 85.0
SHD2_k127_2264762_0 PFAM membrane bound O-acyl transferase MBOAT family protein K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 603.0
SHD2_k127_2264762_1 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 515.0
SHD2_k127_2264762_2 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 457.0
SHD2_k127_2264762_3 O-antigen ligase like membrane protein K02847 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005853 239.0
SHD2_k127_2278934_0 SMART von Willebrand factor type A - - - 4.841e-259 810.0
SHD2_k127_2278934_1 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 7.14e-216 670.0
SHD2_k127_2278934_2 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 499.0
SHD2_k127_2278934_3 ATPase associated with various cellular activities AAA_5 K04748 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 464.0
SHD2_k127_2278934_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000005122 168.0
SHD2_k127_2278934_5 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000002728 130.0
SHD2_k127_2281218_0 Aminotransferase class-III K01845 - 5.4.3.8 8.24e-261 805.0
SHD2_k127_2281218_1 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 349.0
SHD2_k127_2281218_2 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 302.0
SHD2_k127_2281218_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001084 259.0
SHD2_k127_2281218_4 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000003035 148.0
SHD2_k127_2288909_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 556.0
SHD2_k127_2288909_1 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000001039 235.0
SHD2_k127_2297962_0 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 458.0
SHD2_k127_2297962_1 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 314.0
SHD2_k127_2297962_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000003515 221.0
SHD2_k127_2297962_3 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000000000000000004365 143.0
SHD2_k127_2297962_4 FMN binding - - - 0.00000000000000000000000001222 110.0
SHD2_k127_2302244_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 1.231e-222 697.0
SHD2_k127_2302244_1 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 329.0
SHD2_k127_2302244_2 Protein of unknown function (DUF615) K09889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001357 246.0
SHD2_k127_2319581_0 Short-chain dehydrogenase reductase (SDR) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 413.0
SHD2_k127_2319581_1 Oxygen tolerance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004226 385.0
SHD2_k127_2319581_10 - - - - 0.0000000000000002072 83.0
SHD2_k127_2319581_11 - - - - 0.00000000005586 67.0
SHD2_k127_2319581_4 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 318.0
SHD2_k127_2319581_5 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009536 318.0
SHD2_k127_2319581_6 Mate efflux family protein K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000009227 231.0
SHD2_k127_2319581_8 Putative zinc- or iron-chelating domain - - - 0.0000000000000000000000000000000000009626 143.0
SHD2_k127_2319581_9 PFAM heat shock protein DnaJ domain protein - - - 0.000000000000000000000000000000023 130.0
SHD2_k127_2334985_0 Nitrogen metabolism transcriptional regulator, NtrC, Fis Family K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 1.296e-253 794.0
SHD2_k127_2334985_1 Peptidase family U32 C-terminal domain K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 559.0
SHD2_k127_2334985_2 SMART ATP-binding region ATPase domain protein K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004114 542.0
SHD2_k127_2334985_3 chlorophyll binding K02690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 517.0
SHD2_k127_2334985_4 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 315.0
SHD2_k127_2334985_5 Belongs to the peptidase S1B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 316.0
SHD2_k127_2334985_6 Domain of unknown function (DUF386) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002064 267.0
SHD2_k127_2334985_7 Domain of unknown function (DUF4124) - - - 0.0000000000000048 78.0
SHD2_k127_2342334_0 Vitamin B12 dependent methionine synthase activation region K00548 - 2.1.1.13 0.0 1090.0
SHD2_k127_2342334_1 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000005936 210.0
SHD2_k127_2342334_3 Protein of unknown function (DUF2288) - - - 0.00000000000000000000000000000000008341 136.0
SHD2_k127_2342334_4 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000003175 93.0
SHD2_k127_2355796_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1115.0
SHD2_k127_2355796_1 Participates in both transcription termination and antitermination K02600 - - 2.826e-272 842.0
SHD2_k127_2355796_11 - - - - 0.00000000000432 70.0
SHD2_k127_2355796_12 - - - - 0.000000004265 57.0
SHD2_k127_2355796_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 560.0
SHD2_k127_2355796_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009354 514.0
SHD2_k127_2355796_4 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 433.0
SHD2_k127_2355796_5 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 417.0
SHD2_k127_2355796_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 278.0
SHD2_k127_2355796_7 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000000000000000000000000000006962 228.0
SHD2_k127_2355796_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000000000000000004923 186.0
SHD2_k127_2355796_9 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000000000174 157.0
SHD2_k127_2358286_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1242.0
SHD2_k127_236234_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.016e-257 797.0
SHD2_k127_236234_1 Protein of unknown function (DUF3494) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 502.0
SHD2_k127_236234_2 domain protein K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 494.0
SHD2_k127_236234_3 OmpA-like transmembrane domain K03286 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 451.0
SHD2_k127_236234_4 Pfam:UPF0118 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007581 275.0
SHD2_k127_236234_5 PFAM Protein-tyrosine phosphatase, low molecular weight K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000001633 264.0
SHD2_k127_236234_7 hyperosmotic response K03286,K04065 - - 0.0000000000000000000000000001873 121.0
SHD2_k127_236234_8 Pfam:DUF1049 - - - 0.000000001291 61.0
SHD2_k127_2368271_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 2.48e-227 715.0
SHD2_k127_2368271_1 PFAM aminotransferase, class I K02225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 399.0
SHD2_k127_2368271_2 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 384.0
SHD2_k127_2368271_3 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 349.0
SHD2_k127_2368271_4 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.0000000000000000000000000000000000000000000000000000000000000000000001057 244.0
SHD2_k127_2368271_5 Cob(II)yrinic acid a,c-diamide reductase K04719 - 1.13.11.79 0.000000002076 58.0
SHD2_k127_2381042_0 Domain of unknown function DUF21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 610.0
SHD2_k127_2381042_1 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 545.0
SHD2_k127_2381042_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 507.0
SHD2_k127_2381042_3 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 317.0
SHD2_k127_2381042_4 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001742 280.0
SHD2_k127_2397252_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 521.0
SHD2_k127_2397252_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004314 502.0
SHD2_k127_2397252_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 289.0
SHD2_k127_2397252_3 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004909 242.0
SHD2_k127_2423496_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01539 - 3.6.3.9 0.0 1186.0
SHD2_k127_2423496_1 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000000000000000000000000000001763 217.0
SHD2_k127_2423496_2 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000001846 206.0
SHD2_k127_2423496_3 Belongs to the peptidase S16 family - - - 0.00000000004487 65.0
SHD2_k127_2431908_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 4.727e-233 732.0
SHD2_k127_2431908_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008319 400.0
SHD2_k127_2431908_2 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 314.0
SHD2_k127_2431908_3 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000003961 239.0
SHD2_k127_2431908_4 TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - 0.00000000000000000000000000000000006008 134.0
SHD2_k127_2443634_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 8.463e-230 713.0
SHD2_k127_2443634_1 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 614.0
SHD2_k127_2443634_2 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 496.0
SHD2_k127_2443634_3 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 452.0
SHD2_k127_2443634_4 RNA cap guanine-N2 methyltransferase K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 444.0
SHD2_k127_2443634_5 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 430.0
SHD2_k127_2443634_6 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 389.0
SHD2_k127_2453822_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1371.0
SHD2_k127_2453822_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0 1108.0
SHD2_k127_2453822_10 Nitrate reductase gamma subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 348.0
SHD2_k127_2453822_11 DsrE/DsrF/DrsH-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004734 274.0
SHD2_k127_2453822_12 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002219 259.0
SHD2_k127_2453822_13 Sulfurtransferase TusA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001836 244.0
SHD2_k127_2453822_14 PFAM UspA domain protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000005211 243.0
SHD2_k127_2453822_15 DsrE/DsrF-like family K07235 - - 0.0000000000000000000000000000000000000000000000000000000000000000606 223.0
SHD2_k127_2453822_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007452 227.0
SHD2_k127_2453822_17 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000000000000000000001949 203.0
SHD2_k127_2453822_18 DsrE/DsrF-like family K07236 - - 0.0000000000000000000000000000000000000000000000000000000003713 204.0
SHD2_k127_2453822_19 Cas6 Crispr - - - 0.000000000000000000000000000000000000000000000000000000009647 203.0
SHD2_k127_2453822_2 Cysteine-rich domain - - - 1.556e-290 896.0
SHD2_k127_2453822_20 DsrC like protein K11179 - - 0.000000000000000000000000000000000000000000000000002044 183.0
SHD2_k127_2453822_21 - - - - 0.00000000000000000000000000000000000000000005493 166.0
SHD2_k127_2453822_22 DsrH like protein K07237 - - 0.00000000000000000000000000000000000003994 145.0
SHD2_k127_2453822_23 Sulfurtransferase TusA K04085 - - 0.0000000000000000000000000000003428 124.0
SHD2_k127_2453822_24 - - - - 0.000000000000000000000000000505 123.0
SHD2_k127_2453822_25 - - - - 0.0000000000000000000000007886 105.0
SHD2_k127_2453822_3 Nitrite and sulphite reductase 4Fe-4S domain K11180 - 1.8.99.5 1.76e-271 836.0
SHD2_k127_2453822_4 Nitrite and sulphite reductase 4Fe-4S domain K11181 - 1.8.99.5 4.311e-242 747.0
SHD2_k127_2453822_5 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 548.0
SHD2_k127_2453822_6 4Fe-4S binding domain K21308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000649 489.0
SHD2_k127_2453822_7 DMSO reductase anchor subunit (DmsC) K21309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 467.0
SHD2_k127_2453822_8 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009565 411.0
SHD2_k127_2453822_9 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 398.0
SHD2_k127_2459745_0 glutamine synthetase K01915 - 6.3.1.2 5.426e-287 884.0
SHD2_k127_2459745_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 574.0
SHD2_k127_2459745_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 432.0
SHD2_k127_2459745_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002379 240.0
SHD2_k127_2459745_4 Protein of unknown function (DUF1289) K06938 - - 0.0000000000000000002228 90.0
SHD2_k127_2508971_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 2.14e-228 712.0
SHD2_k127_2508971_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 535.0
SHD2_k127_2508971_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 382.0
SHD2_k127_2508971_3 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000000000000000005306 225.0
SHD2_k127_2508971_4 PFAM Di-haem cytochrome c - - - 0.00000000000000000000000000000000000000000000000002018 183.0
SHD2_k127_2508971_5 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000000000001407 132.0
SHD2_k127_2509868_0 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.0 1376.0
SHD2_k127_2509868_1 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 589.0
SHD2_k127_2509868_2 NADH flavin K09461 - 1.14.13.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 533.0
SHD2_k127_2509868_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 524.0
SHD2_k127_2509868_4 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 422.0
SHD2_k127_2509868_5 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000005311 229.0
SHD2_k127_2509868_6 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000000000000000000002729 171.0
SHD2_k127_2509868_7 AAA domain K07028 - - 0.0000000000000000000000000005756 117.0
SHD2_k127_2509868_9 Diguanylate cyclase - - - 0.000000237 53.0
SHD2_k127_2550097_0 Carbohydrate-selective porin, OprB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 613.0
SHD2_k127_2550097_1 cytochrome c peroxidase K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 513.0
SHD2_k127_2550097_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 391.0
SHD2_k127_2550097_3 Indole-3-glycerol phosphate synthase K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005233 384.0
SHD2_k127_2550097_4 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 351.0
SHD2_k127_2550097_5 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 317.0
SHD2_k127_2550097_6 Gram-negative porin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 299.0
SHD2_k127_2550097_7 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003199 250.0
SHD2_k127_2553878_0 PFAM thiamine pyrophosphate K01652 - 2.2.1.6 0.0 1024.0
SHD2_k127_2553878_1 PFAM permease YjgP YjgQ family protein K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 333.0
SHD2_k127_2553878_2 ACT domain K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 283.0
SHD2_k127_2553878_3 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005262 278.0
SHD2_k127_2553878_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007412 267.0
SHD2_k127_2553878_5 Protein of unknown function (DUF3106) - - - 0.000000000000000121 84.0
SHD2_k127_2561878_0 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 503.0
SHD2_k127_2561878_1 COG1960 Acyl-CoA dehydrogenases K06445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 442.0
SHD2_k127_2561878_2 Arginase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 357.0
SHD2_k127_2572733_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 358.0
SHD2_k127_2572733_1 SpoU rRNA Methylase family K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 323.0
SHD2_k127_2572733_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 316.0
SHD2_k127_2572733_3 transport system periplasmic component K01989 - - 0.000000000000000000000000000000000000000003006 169.0
SHD2_k127_2572733_4 FecR protein - - - 0.0000000000000000000000000000000008117 152.0
SHD2_k127_2594776_0 glutamate synthase alpha subunit domain protein K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2570.0
SHD2_k127_2594776_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0 1069.0
SHD2_k127_2594776_2 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.0 1051.0
SHD2_k127_2594776_3 PFAM Sodium calcium exchanger membrane region K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 351.0
SHD2_k127_2594776_4 VirC1 protein K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 285.0
SHD2_k127_2594776_5 PFAM cytochrome c class I K08738 - - 0.000000000000000000000000000000000000000000000000619 177.0
SHD2_k127_2594776_6 PFAM cytochrome c class I K08738 - - 0.00000000000000000000000000000002469 128.0
SHD2_k127_2751700_0 SMART ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 578.0
SHD2_k127_2751700_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 573.0
SHD2_k127_2751700_2 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 379.0
SHD2_k127_2751700_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 353.0
SHD2_k127_2751700_4 SMART ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 339.0
SHD2_k127_2751700_5 response regulator, receiver K02485 - - 0.000000000000000000000000000000000000000000000000000000000000002223 220.0
SHD2_k127_2751700_6 Histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000004749 236.0
SHD2_k127_2751700_7 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000002342 192.0
SHD2_k127_2751700_8 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000005582 63.0
SHD2_k127_2760596_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 544.0
SHD2_k127_2760596_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 522.0
SHD2_k127_2760596_2 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 363.0
SHD2_k127_2760596_3 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000008022 203.0
SHD2_k127_2760596_4 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000002527 73.0
SHD2_k127_278100_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 3.368e-206 644.0
SHD2_k127_278100_1 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 389.0
SHD2_k127_278100_2 PFAM Orn Lys Arg decarboxylase major region K01584 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000004845 197.0
SHD2_k127_278100_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000008515 88.0
SHD2_k127_280340_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0 1028.0
SHD2_k127_280340_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000002155 169.0
SHD2_k127_280340_2 - - - - 0.0000001995 58.0
SHD2_k127_2813957_0 Thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 298.0
SHD2_k127_2813957_1 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 293.0
SHD2_k127_2813957_2 - - - - 0.000000000000000000000000000000000000000000000000000000000006522 211.0
SHD2_k127_2813957_3 Glyoxalase-like domain - - - 0.00000000000000000000007405 99.0
SHD2_k127_2813957_4 cyclic nucleotide binding K10914 - - 0.000000000000000000002784 100.0
SHD2_k127_2813957_5 - - - - 0.000000000006502 72.0
SHD2_k127_2813957_6 - - - - 0.0005206 47.0
SHD2_k127_2816363_0 FAD dependent oxidoreductase K00313 - - 4.007e-228 711.0
SHD2_k127_2816363_1 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 539.0
SHD2_k127_2816363_2 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 420.0
SHD2_k127_2816363_3 PFAM porin Gram-negative type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001634 277.0
SHD2_k127_2816363_4 - - - - 0.00000000000000000000000000000000000000000000000000000002278 202.0
SHD2_k127_2816363_5 Could be a 3Fe-4S cluster-containing protein K03855 - - 0.00000000000000000000000000000000000000000000002987 171.0
SHD2_k127_2816363_6 Ferredoxin - - - 0.00000000000000000000000000000000000000000002218 163.0
SHD2_k127_2816363_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000002251 169.0
SHD2_k127_2816363_8 Transcriptional regulator K02019 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000007573 149.0
SHD2_k127_2816363_9 - - - - 0.00000000000003804 77.0
SHD2_k127_281692_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 7.518e-270 837.0
SHD2_k127_281692_1 Belongs to the anaerobic coproporphyrinogen-III oxidase family - GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 1.286e-250 780.0
SHD2_k127_281692_10 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 345.0
SHD2_k127_281692_11 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 339.0
SHD2_k127_281692_12 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 329.0
SHD2_k127_281692_13 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 304.0
SHD2_k127_281692_14 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000001225 124.0
SHD2_k127_281692_15 transfer protein - - - 0.0000000000000000000000000000001657 139.0
SHD2_k127_281692_16 ThiS family K03154 - - 0.00000000000000000000000205 103.0
SHD2_k127_281692_2 Nitronate monooxygenase K00459 - 1.13.12.16 7.543e-240 744.0
SHD2_k127_281692_3 Involved in the biosynthesis of porphyrin-containing compound - - - 1.27e-206 649.0
SHD2_k127_281692_4 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 463.0
SHD2_k127_281692_5 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007108 450.0
SHD2_k127_281692_6 of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 437.0
SHD2_k127_281692_7 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 410.0
SHD2_k127_281692_8 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009224 385.0
SHD2_k127_281692_9 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008794 353.0
SHD2_k127_2830254_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 1.167e-313 974.0
SHD2_k127_2830254_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 5.578e-275 856.0
SHD2_k127_2830254_2 PFAM RNA-binding protein AU-1 Ribonuclease E G K08301 - - 6.39e-254 791.0
SHD2_k127_2830254_3 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 1.038e-223 700.0
SHD2_k127_2830254_4 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008331 273.0
SHD2_k127_2830254_5 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000000000000000000000000000000001057 248.0
SHD2_k127_2830254_6 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000004281 224.0
SHD2_k127_2830254_7 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000558 165.0
SHD2_k127_2830254_8 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000007216 164.0
SHD2_k127_2838436_0 Belongs to the beta-ketoacyl-ACP synthases family K00647,K09458 - 2.3.1.179,2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004366 552.0
SHD2_k127_2838436_1 polysaccharide deacetylase K01452 - 3.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009111 441.0
SHD2_k127_2838436_2 PAP2 superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 364.0
SHD2_k127_2838436_3 exporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 340.0
SHD2_k127_2840389_0 ABC transporter K02010,K02017,K11072 - 3.6.3.29,3.6.3.30,3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 528.0
SHD2_k127_2840389_1 Pfam Binding-protein-dependent transport systems inner membrane component K02054,K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 436.0
SHD2_k127_2840389_2 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K18005 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.000000000000000000000000000003346 121.0
SHD2_k127_2840389_3 Binding-protein-dependent transport system inner membrane component K11070 - - 0.000000000002142 68.0
SHD2_k127_284416_0 general secretion pathway protein D K02453 - - 4.181e-234 744.0
SHD2_k127_284416_1 type II secretion system protein E K02454,K02652,K12276 - - 3.462e-233 730.0
SHD2_k127_284416_2 General secretion pathway protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 439.0
SHD2_k127_284416_3 peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 344.0
SHD2_k127_284416_4 AraC-binding-like domain - - - 0.000000000000000000000000001274 124.0
SHD2_k127_284416_5 Type II secretion system protein C K02452 - - 0.00000006841 62.0
SHD2_k127_2879436_0 GGDEF EAL family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 348.0
SHD2_k127_2879436_1 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000000000000000000000000000000000000000000001548 202.0
SHD2_k127_2879436_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000001834 96.0
SHD2_k127_2903379_0 PFAM sigma-54 factor interaction domain-containing protein K06714 - - 4.624e-239 743.0
SHD2_k127_2903379_1 Pyridoxal-phosphate dependent enzyme K12339 GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 338.0
SHD2_k127_2928996_0 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 508.0
SHD2_k127_2928996_1 Histidine kinase - - - 0.0000272 48.0
SHD2_k127_2943857_0 anti-sigma regulatory factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 448.0
SHD2_k127_2943857_1 Sigma-70 factor, region 1.2 K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 415.0
SHD2_k127_2943857_10 LPP20 lipoprotein - - - 0.000000000000000000000000000648 126.0
SHD2_k127_2943857_11 chemotaxis, protein K03406 - - 0.0000000000005231 77.0
SHD2_k127_2943857_12 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000003592 52.0
SHD2_k127_2943857_2 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 386.0
SHD2_k127_2943857_3 PFAM Sulfate transporter antisigma-factor antagonist STAS K17763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 370.0
SHD2_k127_2943857_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 367.0
SHD2_k127_2943857_5 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 363.0
SHD2_k127_2943857_6 protein conserved in bacteria K09859 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 339.0
SHD2_k127_2943857_7 Peptidoglycan-synthase activator LpoB K07337 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001938 249.0
SHD2_k127_2943857_8 - K17762 - - 0.00000000000000000000000000000000000000000003436 164.0
SHD2_k127_2943857_9 LPP20 lipoprotein - - - 0.0000000000000000000000000000000004852 139.0
SHD2_k127_296655_0 Histidine kinase - - - 0.0 1345.0
SHD2_k127_296655_1 Response regulator containing a CheY-like receiver domain and an HD-GYP domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 580.0
SHD2_k127_296655_2 Divalent cation transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002392 269.0
SHD2_k127_296655_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000134 210.0
SHD2_k127_296655_4 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000001809 205.0
SHD2_k127_296655_5 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.000000001752 59.0
SHD2_k127_2970727_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.191e-280 865.0
SHD2_k127_2970727_1 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 6.955e-225 701.0
SHD2_k127_2970727_10 Sporulation related domain K03749 - - 0.0000000000000000000000000000000000000001004 158.0
SHD2_k127_2970727_11 Protein of unknown function (DUF2971) - - - 0.000000000000000000000000000000000000006838 158.0
SHD2_k127_2970727_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 608.0
SHD2_k127_2970727_3 PFAM Mur ligase middle domain protein K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 609.0
SHD2_k127_2970727_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 527.0
SHD2_k127_2970727_5 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001269 261.0
SHD2_k127_2970727_6 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000001322 233.0
SHD2_k127_2970727_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000001497 189.0
SHD2_k127_2970727_8 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000005627 179.0
SHD2_k127_2970727_9 Colicin V production protein K03558 - - 0.000000000000000000000000000000000000000001696 161.0
SHD2_k127_3002775_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 7.923e-244 767.0
SHD2_k127_3002775_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 3.241e-229 716.0
SHD2_k127_3099876_0 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004626 558.0
SHD2_k127_3099876_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 380.0
SHD2_k127_3169208_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1030.0
SHD2_k127_3169208_1 Capsule biosynthesis GfcC - - - 1.938e-273 871.0
SHD2_k127_3169208_10 Group 4 capsule polysaccharide lipoprotein gfcB, YjbF - - - 0.00000001203 56.0
SHD2_k127_3169208_2 SMART PDZ DHR GLGF domain protein K11749 - - 7.485e-205 646.0
SHD2_k127_3169208_3 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 7.94e-200 629.0
SHD2_k127_3169208_4 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 498.0
SHD2_k127_3169208_5 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 415.0
SHD2_k127_3169208_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 413.0
SHD2_k127_3169208_7 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005515 391.0
SHD2_k127_3169208_8 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 316.0
SHD2_k127_3169208_9 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 314.0
SHD2_k127_3171907_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0 1098.0
SHD2_k127_3171907_1 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031,K02032 - - 6.331e-214 676.0
SHD2_k127_3171907_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 1.731e-212 670.0
SHD2_k127_3171907_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 554.0
SHD2_k127_3171907_4 interspecies interaction between organisms - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 403.0
SHD2_k127_3171907_5 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 366.0
SHD2_k127_3171907_6 DSBA Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 325.0
SHD2_k127_3187754_0 Outer membrane lipoprotein-sorting protein K07003 - - 5.004e-232 741.0
SHD2_k127_3187754_1 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004343 295.0
SHD2_k127_3187754_2 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000001799 237.0
SHD2_k127_3187754_3 transcriptional regulator K16137 - - 0.0000000000000000000000000000000000000000000003734 173.0
SHD2_k127_3187754_4 Domain of unknown function (DUF4260) - - - 0.00000000000000000000000000000000000000000002342 168.0
SHD2_k127_3187754_5 - - - - 0.00000000000000000000000006134 110.0
SHD2_k127_3197714_0 ATP synthase subunit C K02124 - - 0.0000000000000000000000000000000000000000000000000000000000000000005085 231.0
SHD2_k127_3197714_1 V-type ATPase 116kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000004844 223.0
SHD2_k127_3197714_2 ATP synthase (F/14-kDa) subunit - - - 0.000000000000000000000000000000000000000001759 162.0
SHD2_k127_3197714_3 V-type proton ATPase subunit E K02121 - - 0.000000007425 61.0
SHD2_k127_3278186_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008668 517.0
SHD2_k127_3278186_1 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014,K16089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 310.0
SHD2_k127_3278186_2 - - - - 0.000000000000000000001594 101.0
SHD2_k127_3278412_0 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 469.0
SHD2_k127_3278412_1 PFAM outer membrane chaperone Skp (OmpH) K06142 - - 0.0000000000000000000000000000000000000000000000000005991 189.0
SHD2_k127_3305470_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 1.771e-246 766.0
SHD2_k127_3305470_1 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 451.0
SHD2_k127_3305470_10 Ribosomal protein L9, N-terminal domain K02939 - - 0.0000000000000000000000000000000000000000000000000000000000000004184 224.0
SHD2_k127_3305470_11 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000000000000000000132 217.0
SHD2_k127_3305470_12 - - - - 0.0000000000000000000000000000000000000000249 155.0
SHD2_k127_3305470_13 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000000000000000003084 153.0
SHD2_k127_3305470_14 DNA replication, synthesis of RNA primer K02686 - - 0.00000000000000000000000001051 111.0
SHD2_k127_3305470_15 Protein of unknown function (DUF433) - - - 0.00000000000000000000000004776 109.0
SHD2_k127_3305470_16 Short C-terminal domain - - - 0.000000000000005589 81.0
SHD2_k127_3305470_2 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004676 413.0
SHD2_k127_3305470_3 HELICc2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 312.0
SHD2_k127_3305470_4 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008348 309.0
SHD2_k127_3305470_5 Bacterial protein of unknown function (DUF898) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009879 321.0
SHD2_k127_3305470_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 297.0
SHD2_k127_3305470_7 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 289.0
SHD2_k127_3305470_8 Belongs to the UPF0178 family K09768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006119 265.0
SHD2_k127_3305470_9 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001261 252.0
SHD2_k127_3320926_0 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003764 479.0
SHD2_k127_3320926_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 346.0
SHD2_k127_3320926_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005214 267.0
SHD2_k127_3320926_3 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000005568 149.0
SHD2_k127_3320926_4 Protein of unknown function (DUF2782) - - - 0.000000000000000000000000000007627 123.0
SHD2_k127_3355441_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1021.0
SHD2_k127_3355441_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 6.397e-258 802.0
SHD2_k127_3355441_2 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 7.247e-240 745.0
SHD2_k127_3355441_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 2.953e-226 704.0
SHD2_k127_3355441_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 448.0
SHD2_k127_3355441_5 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002336 273.0
SHD2_k127_3355441_6 Transposase IS200 like K07491 - - 0.000009069 47.0
SHD2_k127_3379709_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 339.0
SHD2_k127_3379709_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001035 253.0
SHD2_k127_3379709_2 YGGT family K02221 - - 0.00000000000001301 81.0
SHD2_k127_3396469_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 2.694e-219 685.0
SHD2_k127_3396469_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 2.037e-202 642.0
SHD2_k127_3396469_2 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 304.0
SHD2_k127_3396469_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001083 245.0
SHD2_k127_3396469_4 - - - - 0.00000000000000000000000000000000005871 135.0
SHD2_k127_3475509_0 Collagenase K08303 - - 0.0 1071.0
SHD2_k127_3475509_1 PFAM ABC transporter related K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 480.0
SHD2_k127_3475509_2 methyltransferase activity K21310 - 2.1.1.334 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 405.0
SHD2_k127_3475509_3 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003096 243.0
SHD2_k127_3475509_4 membrane organization K20543 - - 0.00000000000000000000000000000000000000000000000000000000000000004783 241.0
SHD2_k127_3475509_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000004754 213.0
SHD2_k127_3475509_6 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000005585 204.0
SHD2_k127_3475509_7 - - - - 0.0000000000000000000000000000000000000003077 155.0
SHD2_k127_3475509_8 PFAM cytochrome c class I K08738 - - 0.00000000000000000000000007406 111.0
SHD2_k127_3478133_0 PFAM Dual specificity protein phosphatase K14165 - 3.1.3.16,3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000006431 240.0
SHD2_k127_3478133_1 GTP-binding domain protein K06945 - - 0.00000000000000000000000000000000000000000000000000001621 195.0
SHD2_k127_3478133_2 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.000000000000000000000000001231 113.0
SHD2_k127_3478133_3 - - - - 0.0000000001054 70.0
SHD2_k127_3480543_0 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 435.0
SHD2_k127_3480543_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 435.0
SHD2_k127_3480543_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000004185 201.0
SHD2_k127_3513291_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 0.0 1497.0
SHD2_k127_3513291_1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 587.0
SHD2_k127_3513291_2 PFAM sigma-54 factor interaction domain-containing protein K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007195 330.0
SHD2_k127_3513291_3 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000561 284.0
SHD2_k127_3516312_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 8.811e-243 760.0
SHD2_k127_3516312_1 Alpha/beta hydrolase family K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 548.0
SHD2_k127_3516312_10 YaeQ - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 327.0
SHD2_k127_3516312_11 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 332.0
SHD2_k127_3516312_12 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003582 286.0
SHD2_k127_3516312_13 Ankyrin repeats (many copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001312 259.0
SHD2_k127_3516312_14 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000001616 215.0
SHD2_k127_3516312_15 DsrC like protein K11179 - - 0.000000000000000000000000000000000000000000000000000002827 191.0
SHD2_k127_3516312_16 PFAM Glutathione S-transferase, N-terminal domain K11209 - - 0.00000000000000000000000000000000000000000000000000003347 194.0
SHD2_k127_3516312_17 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000007684 194.0
SHD2_k127_3516312_18 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000002005 184.0
SHD2_k127_3516312_19 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000000000217 175.0
SHD2_k127_3516312_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 486.0
SHD2_k127_3516312_20 Lipid A 3-O-deacylase (PagL) - - - 0.0000000000000000000000000000000000000000000001338 174.0
SHD2_k127_3516312_21 - - - - 0.000000000000000000000000000000000000000003218 157.0
SHD2_k127_3516312_22 PQ loop repeat K15383 - - 0.00000000000000000000000000000003456 127.0
SHD2_k127_3516312_23 - - - - 0.0000000000000000000000000000006905 127.0
SHD2_k127_3516312_24 aminoacyl-histidine dipeptidase K01270 - - 0.000000000000000000000000005443 109.0
SHD2_k127_3516312_25 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000004305 106.0
SHD2_k127_3516312_26 - - - - 0.00000000000000000001614 93.0
SHD2_k127_3516312_27 - - - - 0.0000000000000000001353 91.0
SHD2_k127_3516312_28 Protein of unknown function (DUF2621) - - - 0.000000005542 65.0
SHD2_k127_3516312_29 phosphoglycerate K15634,K15640 - 5.4.2.12 0.0000001628 60.0
SHD2_k127_3516312_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 457.0
SHD2_k127_3516312_31 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000004284 53.0
SHD2_k127_3516312_4 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 437.0
SHD2_k127_3516312_5 Belongs to the pseudouridine synthase RsuA family K06183 - 5.4.99.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 425.0
SHD2_k127_3516312_6 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 424.0
SHD2_k127_3516312_7 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 339.0
SHD2_k127_3516312_8 PFAM nitroreductase K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008693 334.0
SHD2_k127_3516312_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 334.0
SHD2_k127_351758_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 7.313e-239 744.0
SHD2_k127_351758_1 Thioredoxin K05838 - - 0.00000000000000000000000000000000000000000000000000009817 187.0
SHD2_k127_351758_2 - - - - 0.0000000002409 65.0
SHD2_k127_353331_0 PFAM type II secretion system protein E K02669,K12203 - - 8.262e-204 641.0
SHD2_k127_353331_1 PFAM type II secretion system protein E K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 476.0
SHD2_k127_353331_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000005643 166.0
SHD2_k127_3544462_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 3.379e-224 705.0
SHD2_k127_3544462_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 6.55e-220 694.0
SHD2_k127_3544462_10 FeoA K04758 - - 0.0000000000000000000003465 104.0
SHD2_k127_3544462_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 527.0
SHD2_k127_3544462_3 KR domain K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 402.0
SHD2_k127_3544462_4 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 366.0
SHD2_k127_3544462_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 359.0
SHD2_k127_3544462_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004201 275.0
SHD2_k127_3544462_7 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003296 246.0
SHD2_k127_3544462_8 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000001988 221.0
SHD2_k127_3544462_9 NlpB/DapX lipoprotein K07287 - - 0.0000000000000000000000000002084 124.0
SHD2_k127_3546871_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 2.164e-268 843.0
SHD2_k127_3546871_1 PFAM UMUC domain protein DNA-repair protein K03502 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 552.0
SHD2_k127_3546871_10 Protein of unknown function (DUF2892) - - - 0.000006165 53.0
SHD2_k127_3546871_2 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 478.0
SHD2_k127_3546871_3 Uncharacterized protein conserved in bacteria (DUF2239) K09965 - - 0.00000000000000000000000000000000000000000000000000000000000002792 220.0
SHD2_k127_3546871_4 Belongs to the peptidase S24 family K03503 - - 0.00000000000000000000000000000000000000000000000000222 186.0
SHD2_k127_3546871_5 GGDEF Domain - - - 0.00000000000000000000000000000000000000000000007587 184.0
SHD2_k127_3546871_6 - - - - 0.000000000000000000000000000000000000143 143.0
SHD2_k127_3546871_7 Transcriptional regulator - - - 0.000000000000000000000000000003096 122.0
SHD2_k127_3546871_8 DNA helicase - - - 0.000000000000001533 76.0
SHD2_k127_3559441_0 Protein of unknown function (DUF3050) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 308.0
SHD2_k127_3559441_1 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000212 252.0
SHD2_k127_3559441_2 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.0000000000000000000000000000000000000000000000000000001415 196.0
SHD2_k127_3559441_3 PFAM HPP family protein K07168 - - 0.000000000000000000000000000000000000000000000001467 184.0
SHD2_k127_3559441_4 Iron-sulphur cluster assembly - - - 0.00000000000000000000000000002861 117.0
SHD2_k127_3559441_5 geranylgeranyl reductase activity K10960,K17830 - 1.3.1.101,1.3.1.111,1.3.1.83,1.3.7.11 0.00000000000003331 80.0
SHD2_k127_3581732_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1771.0
SHD2_k127_3581732_1 serine threonine protein kinase K12132 - 2.7.11.1 4.047e-200 630.0
SHD2_k127_3581732_2 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 583.0
SHD2_k127_3581732_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000004551 150.0
SHD2_k127_3581732_4 TPR repeat - - - 0.000000000000000000000000000000000001161 143.0
SHD2_k127_3581732_5 membrane - - - 0.0000000009158 64.0
SHD2_k127_3606855_0 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 586.0
SHD2_k127_3606855_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 494.0
SHD2_k127_3606855_2 General secretory system II protein E domain protein K02454,K02652,K12276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 435.0
SHD2_k127_3606855_3 - - - - 0.0000000000000000000000000000000000000000000000000000001149 201.0
SHD2_k127_3606855_4 - - - - 0.000000000000000000000000002193 119.0
SHD2_k127_3624875_0 cytochrome c biogenesis protein - - - 4.364e-245 770.0
SHD2_k127_3624875_1 methionine sulfoxide reductase K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006436 280.0
SHD2_k127_3624875_2 Protein of unknown function (DUF1109) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001084 278.0
SHD2_k127_3624875_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002766 265.0
SHD2_k127_3624875_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006023 265.0
SHD2_k127_3660557_0 PFAM DEAD DEAH box helicase domain protein - GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - 6.404e-222 700.0
SHD2_k127_3660557_1 PFAM iron permease FTR1 K07243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 397.0
SHD2_k127_3660557_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 359.0
SHD2_k127_3660557_3 Cupredoxin-like domain - - - 0.00000000000000000000000000000000000000001038 155.0
SHD2_k127_3660557_4 Cation transporting ATPase, C-terminus K01537 - 3.6.3.8 0.00000000000000000000001449 102.0
SHD2_k127_3660557_5 PFAM ferric-uptake regulator K03711 - - 0.0000000006119 60.0
SHD2_k127_3710573_0 Sugar (and other) transporter - - - 1.093e-245 768.0
SHD2_k127_3710573_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007417 629.0
SHD2_k127_3710573_2 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 571.0
SHD2_k127_3710573_3 ABC transporter C-terminal domain K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 486.0
SHD2_k127_3710573_4 ZIP Zinc transporter K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 362.0
SHD2_k127_3710573_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000003 174.0
SHD2_k127_3710573_6 OmpA-like transmembrane domain - - - 0.0001078 52.0
SHD2_k127_3720041_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 5.851e-235 731.0
SHD2_k127_3720041_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007586 266.0
SHD2_k127_3720041_2 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000001755 93.0
SHD2_k127_3747690_0 ATP synthase subunit D K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007901 349.0
SHD2_k127_3747690_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 318.0
SHD2_k127_3747690_2 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000000328 64.0
SHD2_k127_37544_0 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 4.093e-207 647.0
SHD2_k127_37544_1 Carbohydrate kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004646 589.0
SHD2_k127_37544_2 Domain of unknown function (DUF3393) K08306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 492.0
SHD2_k127_37544_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 332.0
SHD2_k127_37544_4 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006909 272.0
SHD2_k127_37544_5 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000005376 207.0
SHD2_k127_37544_6 Bacterial-like globin - - - 0.00000000000000000000000000000000000000000000000000000001503 205.0
SHD2_k127_37544_7 Bacterial-like globin K06886 - - 0.00000000000000000000000000000000000000000000000000000008261 197.0
SHD2_k127_37544_8 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000009608 191.0
SHD2_k127_37544_9 Domain of unknown function (DUF4149) - - - 0.0000000000000000000000000000000000000000000000001718 181.0
SHD2_k127_382349_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1057.0
SHD2_k127_382349_1 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 5.891e-312 968.0
SHD2_k127_382349_10 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000000000008892 109.0
SHD2_k127_382349_2 Ring hydroxylating alpha subunit (catalytic domain) K00499 - 1.14.15.7 9.727e-219 681.0
SHD2_k127_382349_3 Polyprenyl synthetase K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 477.0
SHD2_k127_382349_4 Type I GTP cyclohydrolase folE2 K09007 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007388 465.0
SHD2_k127_382349_5 EamA-like transporter family K15270 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 391.0
SHD2_k127_382349_6 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 359.0
SHD2_k127_382349_7 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000000000000987 204.0
SHD2_k127_382349_8 - - - - 0.000000000000000000000000000000000000000000000000002482 188.0
SHD2_k127_382349_9 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000007235 185.0
SHD2_k127_3824763_0 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 493.0
SHD2_k127_3824763_1 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 385.0
SHD2_k127_3824763_2 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.000000000000000000000000000000000000000000000000000000000004984 214.0
SHD2_k127_3824763_3 molybdopterin biosynthesis MoaE K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000003317 195.0
SHD2_k127_3824763_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000003194 89.0
SHD2_k127_3824763_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000001889 81.0
SHD2_k127_3861842_0 ABC1 family K03688 - - 5.912e-253 792.0
SHD2_k127_3861842_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 465.0
SHD2_k127_3861842_2 - - - - 0.0000000000000000000000000000000000000000000000000000002833 200.0
SHD2_k127_3861842_3 Diguanylate cyclase - - - 0.000001286 50.0
SHD2_k127_3874620_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 4.018e-258 797.0
SHD2_k127_3874620_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 563.0
SHD2_k127_3874620_10 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000000000002585 117.0
SHD2_k127_3874620_2 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645,K13935,K15355 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 534.0
SHD2_k127_3874620_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 498.0
SHD2_k127_3874620_4 KR domain K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 408.0
SHD2_k127_3874620_5 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 404.0
SHD2_k127_3874620_6 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001202 278.0
SHD2_k127_3874620_7 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004663 266.0
SHD2_k127_3874620_8 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000000127 150.0
SHD2_k127_3874620_9 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000001227 139.0
SHD2_k127_3902437_0 MacB-like periplasmic core domain K02004 - - 1.414e-219 694.0
SHD2_k127_3902437_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 364.0
SHD2_k127_3902437_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000004478 157.0
SHD2_k127_3902437_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000004237 137.0
SHD2_k127_3932969_0 Cytochrome bd-type quinol oxidase, subunit 1 K00425 - 1.10.3.14 2.49e-248 777.0
SHD2_k127_3932969_1 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 531.0
SHD2_k127_3932969_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000002132 262.0
SHD2_k127_3932969_3 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000003474 222.0
SHD2_k127_3932969_4 Cyd operon protein YbgT K00424 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019867,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0071944 1.10.3.14 0.000000002436 59.0
SHD2_k127_4007663_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 3.162e-247 777.0
SHD2_k127_4007663_1 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 0.0000000000000000000000000002571 117.0
SHD2_k127_4009567_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1219.0
SHD2_k127_4009567_1 LytTr DNA-binding domain K08083 - - 0.000000000000000000000000000000000000000000000000001409 185.0
SHD2_k127_4010008_0 ROK family K00845,K00847,K00884 - 2.7.1.2,2.7.1.4,2.7.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 520.0
SHD2_k127_4010008_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 489.0
SHD2_k127_4010008_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004634 277.0
SHD2_k127_4010008_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003313 252.0
SHD2_k127_4010008_4 - - - - 0.000000000000000000000000000000000001441 154.0
SHD2_k127_4010008_5 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.000000000000000000000000000000000005924 143.0
SHD2_k127_4010008_6 - - - - 0.0000000000000001787 80.0
SHD2_k127_404458_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008948 582.0
SHD2_k127_404458_1 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000000000000005226 254.0
SHD2_k127_404458_2 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000000000000000000000000001721 198.0
SHD2_k127_404458_3 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.0000000000000000000000003117 105.0
SHD2_k127_404458_4 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000006426 74.0
SHD2_k127_4075949_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1101.0
SHD2_k127_4075949_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 2.008e-278 864.0
SHD2_k127_4075949_2 PFAM peptidase S1 and S6 chymotrypsin Hap K04771 - 3.4.21.107 2.501e-212 667.0
SHD2_k127_4075949_3 PFAM Peptidase S24 S26A S26B, conserved region K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000842 412.0
SHD2_k127_4075949_4 MucB/RseB C-terminal domain K03598 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 390.0
SHD2_k127_4075949_5 TIGRFAM RNA polymerase sigma factor RpoE K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 358.0
SHD2_k127_4075949_6 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 291.0
SHD2_k127_4075949_7 PFAM Anti sigma-E protein RseA family protein K03597 - - 0.00000000000000000000000000000000000000000000000000000002602 200.0
SHD2_k127_4075949_8 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.00000000000000000001417 97.0
SHD2_k127_4075949_9 - - - - 0.00000000000000000003194 96.0
SHD2_k127_4132611_0 Major Facilitator Superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 471.0
SHD2_k127_4132611_1 Major Facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 302.0
SHD2_k127_4132611_2 membrane protein, terc - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004648 253.0
SHD2_k127_4132611_3 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 0.00000000000000000000000000000000000000000009179 160.0
SHD2_k127_4182547_0 water channel activity K02440,K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 380.0
SHD2_k127_4182547_1 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 344.0
SHD2_k127_4182547_2 Part of a membrane complex involved in electron transport K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 317.0
SHD2_k127_4182547_3 Part of a membrane complex involved in electron transport K03615 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007786 261.0
SHD2_k127_4182547_5 SMART RNA-binding S4 domain protein K04762 - - 0.0000000000000000000000000000000000001847 149.0
SHD2_k127_4200863_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 488.0
SHD2_k127_4200863_1 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 391.0
SHD2_k127_4200863_2 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 363.0
SHD2_k127_4200863_3 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 295.0
SHD2_k127_4200863_4 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006727 297.0
SHD2_k127_4200863_5 Frataxin-like domain K06202 - - 0.000000000000000000000000000000000000000002826 157.0
SHD2_k127_4220280_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.996e-195 611.0
SHD2_k127_4220280_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 435.0
SHD2_k127_4220280_2 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000007876 122.0
SHD2_k127_4221238_0 General secretory system II protein E domain protein K02454,K02652,K12276 - - 2.242e-243 764.0
SHD2_k127_4221238_1 Virulence factor membrane-bound polymerase, C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007106 569.0
SHD2_k127_4221238_2 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 480.0
SHD2_k127_4221238_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009378 491.0
SHD2_k127_4221238_4 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000000000000000000000003658 260.0
SHD2_k127_4221238_5 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000000000000000000000000000000001488 221.0
SHD2_k127_4221238_6 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000002322 166.0
SHD2_k127_4221238_7 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000000001029 135.0
SHD2_k127_4221238_8 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000963 128.0
SHD2_k127_4227729_0 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 431.0
SHD2_k127_4227729_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009523 376.0
SHD2_k127_4227729_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 312.0
SHD2_k127_4227729_3 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 288.0
SHD2_k127_4227729_4 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000257 272.0
SHD2_k127_4242242_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14392 - - 8.279e-281 867.0
SHD2_k127_4242242_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 4.836e-257 798.0
SHD2_k127_4242242_10 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07032 - - 0.000000000000000000000000000000000000000000000000000000000000000002442 228.0
SHD2_k127_4242242_11 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.0000000000000000000000000000000000000000000000000003362 188.0
SHD2_k127_4242242_12 Response regulator receiver K02658 - - 0.000000000000000000000000000000000000000000000000000371 186.0
SHD2_k127_4242242_13 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000002818 162.0
SHD2_k127_4242242_14 CheW-like domain - - - 0.000000000000000000000000000000002822 135.0
SHD2_k127_4242242_15 - - - - 0.00000000000000000000004889 104.0
SHD2_k127_4242242_17 Phosphoribulokinase / Uridine kinase family K00855 - 2.7.1.19 0.00000000000004093 72.0
SHD2_k127_4242242_2 response regulator receiver - - - 3.239e-240 781.0
SHD2_k127_4242242_3 TIGRFAM phosphate regulon sensor kinase PhoR K07636 - 2.7.13.3 3.845e-196 619.0
SHD2_k127_4242242_4 pfkB family carbohydrate kinase K00852,K00856 - 2.7.1.15,2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 502.0
SHD2_k127_4242242_5 chemotaxis, protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 451.0
SHD2_k127_4242242_6 Fructosamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007756 432.0
SHD2_k127_4242242_7 Two component transcriptional regulator PhoB, winged helix family K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 389.0
SHD2_k127_4242242_8 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 373.0
SHD2_k127_4242242_9 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K02021,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 289.0
SHD2_k127_4242365_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 0.0 2011.0
SHD2_k127_4242365_1 Protein of unknown function - - - 0.0 1258.0
SHD2_k127_4242365_2 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1238.0
SHD2_k127_4242365_3 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 5.812e-262 813.0
SHD2_k127_4242365_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 9.908e-221 687.0
SHD2_k127_4242365_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 584.0
SHD2_k127_4242365_6 PFAM Adenylyl cyclase class-3 4 guanylyl cyclase K01769 - 4.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 576.0
SHD2_k127_4242365_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 472.0
SHD2_k127_4242365_8 PFAM cytochrome c class I K08738 - - 0.000000000000000000004687 100.0
SHD2_k127_4242365_9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000001435 88.0
SHD2_k127_4248292_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 566.0
SHD2_k127_4248292_1 PFAM permease YjgP YjgQ family protein K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 520.0
SHD2_k127_4248292_2 PFAM permease YjgP YjgQ family protein K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000233 243.0
SHD2_k127_4274123_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.248e-252 779.0
SHD2_k127_4274123_1 Transposase IS200 like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 467.0
SHD2_k127_4274123_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000000000000000000000000000000000004506 216.0
SHD2_k127_4274123_3 YoeB-like toxin of bacterial type II toxin-antitoxin system - - - 0.0000000000000000000000000000000000000000000005811 166.0
SHD2_k127_4274123_4 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000002595 113.0
SHD2_k127_4274123_5 Pfam:DUF1311 - - - 0.0000000000000000000000268 105.0
SHD2_k127_4292393_0 beta-lactamase domain protein K01120 - 3.1.4.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 386.0
SHD2_k127_4292393_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000002067 234.0
SHD2_k127_4292393_2 PFAM Class I peptide chain release factor K15034 - - 0.0000000000000000000000000000000000000000000000000000008119 201.0
SHD2_k127_4292393_3 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000434 175.0
SHD2_k127_4292393_4 S4 domain K14761 - - 0.00000000000000000000000000001211 122.0
SHD2_k127_4292393_5 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.000000000000000007659 82.0
SHD2_k127_4292393_6 - - - - 0.000000000000419 75.0
SHD2_k127_4316912_0 AcrB/AcrD/AcrF family - - - 0.0 1066.0
SHD2_k127_4316912_1 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic domain K01886 - 6.1.1.18 1.237e-313 964.0
SHD2_k127_4316912_2 Multi-copper - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 467.0
SHD2_k127_4316912_3 Copper binding proteins, plastocyanin/azurin family K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 402.0
SHD2_k127_4316912_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 398.0
SHD2_k127_4316912_5 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 334.0
SHD2_k127_4316912_6 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000001617 267.0
SHD2_k127_4316912_7 cytochrome C, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007731 268.0
SHD2_k127_4316912_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000003022 227.0
SHD2_k127_4316912_9 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000000000000000000000000005328 142.0
SHD2_k127_4385687_0 (GGDEF) domain - - - 1.841e-209 685.0
SHD2_k127_4385687_1 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 586.0
SHD2_k127_4385687_2 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004417 372.0
SHD2_k127_4385687_3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000000001461 161.0
SHD2_k127_4385687_4 NMT1-like family K02051 - - 0.00000000000000000004561 100.0
SHD2_k127_4385687_5 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000004648 80.0
SHD2_k127_4399923_0 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 488.0
SHD2_k127_4399923_1 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 499.0
SHD2_k127_4399923_10 Chemoreceptor zinc-binding domain - - - 0.000000000000000000000000000000000000000021 157.0
SHD2_k127_4399923_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 455.0
SHD2_k127_4399923_3 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 364.0
SHD2_k127_4399923_4 TIGRFAM DNA-3-methyladenine glycosylase I K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 288.0
SHD2_k127_4399923_5 Protein of unknown function, DUF484 K09921 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 284.0
SHD2_k127_4399923_6 SMART CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000000000000000000000007391 205.0
SHD2_k127_4399923_7 Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000000000004697 186.0
SHD2_k127_4399923_8 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000003603 177.0
SHD2_k127_4399923_9 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000002785 176.0
SHD2_k127_4400146_0 Heat shock 70 kDa protein K04043 - - 2.219e-294 913.0
SHD2_k127_4400146_1 Belongs to the peptidase S16 family - - - 5.957e-272 859.0
SHD2_k127_4400146_10 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.0000000000004198 72.0
SHD2_k127_4400146_11 ABC transporter - - - 0.000000000002626 75.0
SHD2_k127_4400146_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 1.407e-256 799.0
SHD2_k127_4400146_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 428.0
SHD2_k127_4400146_4 ribosomal large subunit export from nucleus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004987 248.0
SHD2_k127_4400146_5 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000001763 199.0
SHD2_k127_4400146_6 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000006281 177.0
SHD2_k127_4400146_7 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000003242 166.0
SHD2_k127_4400146_8 FecR protein - - - 0.000000000000000000008926 104.0
SHD2_k127_4400146_9 Tetratricopeptide repeat - - - 0.000000000000000001836 95.0
SHD2_k127_4450420_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1e-323 1002.0
SHD2_k127_4450420_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 6.276e-239 742.0
SHD2_k127_4450420_10 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 376.0
SHD2_k127_4450420_11 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 368.0
SHD2_k127_4450420_12 cellulose synthase operon C domain protein K20543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005984 357.0
SHD2_k127_4450420_13 Protein of unknown function (DUF3025) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 338.0
SHD2_k127_4450420_14 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000732 297.0
SHD2_k127_4450420_15 Small Multidrug Resistance protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000007978 231.0
SHD2_k127_4450420_16 Haem-degrading - - - 0.0000000000000000000000000000000000000000000000000000000000000000008816 231.0
SHD2_k127_4450420_17 Glycosyl transferase family 2 K10012 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000006536 211.0
SHD2_k127_4450420_18 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000000000000000000007958 198.0
SHD2_k127_4450420_19 Trm112p-like protein K09791 - - 0.000000000000000512 79.0
SHD2_k127_4450420_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 1.835e-234 739.0
SHD2_k127_4450420_3 Belongs to the DegT DnrJ EryC1 family - - - 1.858e-221 689.0
SHD2_k127_4450420_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 604.0
SHD2_k127_4450420_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 512.0
SHD2_k127_4450420_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 497.0
SHD2_k127_4450420_7 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 467.0
SHD2_k127_4450420_8 Cellulose biosynthesis protein BcsG - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 457.0
SHD2_k127_4450420_9 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 428.0
SHD2_k127_4453160_0 B3/4 domain K01890 - 6.1.1.20 0.0 1259.0
SHD2_k127_4453160_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 1.943e-204 637.0
SHD2_k127_4453160_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 329.0
SHD2_k127_4453160_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000000000000000001261 213.0
SHD2_k127_4453160_4 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000000000000000002367 194.0
SHD2_k127_4453160_5 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000008072 168.0
SHD2_k127_4453160_6 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000000000000531 110.0
SHD2_k127_4467348_0 Hsp70 protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.0 1133.0
SHD2_k127_4467348_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007902 566.0
SHD2_k127_4467348_10 Nucleoside H+ symporter K05820 - - 0.0000000000000000000001919 96.0
SHD2_k127_4467348_2 COG0714 MoxR-like ATPases K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 361.0
SHD2_k127_4467348_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 343.0
SHD2_k127_4467348_4 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 319.0
SHD2_k127_4467348_5 ErfK ybiS ycfS ynhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003061 282.0
SHD2_k127_4467348_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003558 276.0
SHD2_k127_4467348_7 LemA Family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007992 275.0
SHD2_k127_4467348_8 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003384 235.0
SHD2_k127_4471664_0 Domain of unknown function (DUF3400) - - - 0.0 1344.0
SHD2_k127_4471664_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 2.703e-217 683.0
SHD2_k127_4471664_10 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00000000000000000000000000000000000000000000000006587 184.0
SHD2_k127_4471664_11 PFAM sigma 54 modulation protein ribosomal protein S30EA K05808 - - 0.00000000000000000000000000000000000000000001295 164.0
SHD2_k127_4471664_12 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000001309 148.0
SHD2_k127_4471664_13 NusG domain II - - - 0.0000000000001982 75.0
SHD2_k127_4471664_2 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 482.0
SHD2_k127_4471664_3 P-loop ATPase protein family K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 435.0
SHD2_k127_4471664_4 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 429.0
SHD2_k127_4471664_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 435.0
SHD2_k127_4471664_6 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 384.0
SHD2_k127_4471664_7 PFAM Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002129 269.0
SHD2_k127_4471664_8 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000000001151 233.0
SHD2_k127_4471664_9 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000000000000000000000000000000002582 196.0
SHD2_k127_4474181_0 PFAM ABC transporter related - - - 0.0 1027.0
SHD2_k127_4474181_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 3.131e-300 928.0
SHD2_k127_4474181_10 PFAM PTS system fructose subfamily IIA component K02821 - 2.7.1.194 0.00000000000000000000000000000000000000000000000747 175.0
SHD2_k127_4474181_11 mRNA binding - - - 0.000000000000000000000000000000000004352 138.0
SHD2_k127_4474181_12 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000004575 140.0
SHD2_k127_4474181_13 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000000000000008221 127.0
SHD2_k127_4474181_14 Transposase IS200 like - - - 0.00000000000000000002333 91.0
SHD2_k127_4474181_2 Glutamate-cysteine ligase K01919 - 6.3.2.2 7.25e-256 791.0
SHD2_k127_4474181_3 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 1.113e-204 639.0
SHD2_k127_4474181_4 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 524.0
SHD2_k127_4474181_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 515.0
SHD2_k127_4474181_6 PFAM DEAD DEAH box helicase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 458.0
SHD2_k127_4474181_7 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 369.0
SHD2_k127_4474181_8 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.000000000000000000000000000000000000000000000000000008425 194.0
SHD2_k127_4474181_9 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000007048 177.0
SHD2_k127_449906_0 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 4.454e-225 707.0
SHD2_k127_449906_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 602.0
SHD2_k127_449906_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 284.0
SHD2_k127_449906_3 Belongs to the UPF0225 family K09858 - - 0.0000000000000000000000000000000000002818 143.0
SHD2_k127_4519027_0 AcrB/AcrD/AcrF family - - - 0.0 1475.0
SHD2_k127_4519027_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1113.0
SHD2_k127_4519027_10 Belongs to the GPI family K01810 GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 300.0
SHD2_k127_4519027_11 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000005245 268.0
SHD2_k127_4519027_12 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001295 226.0
SHD2_k127_4519027_13 Protein of unknown function (DUF2892) - - - 0.00000000000000000000000001004 111.0
SHD2_k127_4519027_14 PFAM Tetratricopeptide repeat K07126 - - 0.0000000000000000000003295 102.0
SHD2_k127_4519027_15 Beta-xylanase K01181 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010383,GO:0010410,GO:0016052,GO:0016787,GO:0016798,GO:0030312,GO:0031176,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0045491,GO:0045493,GO:0071554,GO:0071704,GO:0071944,GO:0097599,GO:1901575 3.2.1.8 0.00000000000000008259 91.0
SHD2_k127_4519027_16 Protein of unknown function (DUF2934) - - - 0.0000000000000001115 84.0
SHD2_k127_4519027_17 Virulence factor membrane-bound polymerase, C-terminal - - - 0.00000000000007646 72.0
SHD2_k127_4519027_2 Domain of unknown function (DUF1926) K22451 - 2.4.1.25 1.489e-282 882.0
SHD2_k127_4519027_3 PFAM peptidase M17 leucyl aminopeptidase domain protein K01255 - 3.4.11.1 3.523e-252 784.0
SHD2_k127_4519027_4 Belongs to the glycosyl hydrolase 57 family - - - 3.902e-237 746.0
SHD2_k127_4519027_5 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 2.901e-222 694.0
SHD2_k127_4519027_6 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 525.0
SHD2_k127_4519027_7 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 338.0
SHD2_k127_4519027_8 PFAM ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000928 328.0
SHD2_k127_4519027_9 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 334.0
SHD2_k127_454179_0 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 452.0
SHD2_k127_454179_1 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 376.0
SHD2_k127_454179_2 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 329.0
SHD2_k127_454179_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000003261 217.0
SHD2_k127_454179_4 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.00000000000000000000000001282 110.0
SHD2_k127_454179_5 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000000002993 91.0
SHD2_k127_4568263_0 General secretory system II protein E domain protein K02454,K02652,K12276 - - 4.601e-209 654.0
SHD2_k127_4568263_1 PFAM Type II secretion system F domain K02455,K12278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 601.0
SHD2_k127_4568263_2 general secretion pathway protein K02456,K02457,K02458,K10930,K12285 - - 0.000000000000000000000000000000000000000000000000000008253 194.0
SHD2_k127_4568263_3 Prokaryotic N-terminal methylation motif K10924 - - 0.0000000000000000000000000000000001664 138.0
SHD2_k127_4568263_4 Prokaryotic N-terminal methylation motif - - - 0.000000007829 64.0
SHD2_k127_4568263_5 Prokaryotic N-terminal methylation motif K10926 - - 0.0004502 50.0
SHD2_k127_4568263_6 general secretion pathway protein K02456,K02457,K02458,K02459,K10927 - - 0.0006452 48.0
SHD2_k127_4588878_0 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 463.0
SHD2_k127_4588878_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004876 276.0
SHD2_k127_4588878_2 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000004242 227.0
SHD2_k127_4588878_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000005325 175.0
SHD2_k127_4600402_0 cytochrome C peroxidase - - - 7.997e-259 806.0
SHD2_k127_4600402_1 PFAM NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 313.0
SHD2_k127_4600402_2 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001139 237.0
SHD2_k127_4600402_3 - - - - 0.0000000000000000003644 89.0
SHD2_k127_4600402_4 Prolyl oligopeptidase family K00433 - 1.11.1.10 0.000000000000000002392 84.0
SHD2_k127_4600402_5 Prolyl oligopeptidase family K00433 - 1.11.1.10 0.000000000000001371 76.0
SHD2_k127_4634029_0 His Kinase A (phosphoacceptor) domain - - - 1.24e-315 987.0
SHD2_k127_4634029_1 SMART HTH transcriptional regulator, Crp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 377.0
SHD2_k127_4634029_10 Pfam:UPF0118 - - - 0.0000000000000000000000003163 105.0
SHD2_k127_4634029_11 CsbD-like - - - 0.0000000000000000000001958 98.0
SHD2_k127_4634029_12 Protein of unknown function (DUF3309) - - - 0.000000000000000000002658 94.0
SHD2_k127_4634029_13 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K03286 - - 0.00000000000000003797 88.0
SHD2_k127_4634029_14 - - - - 0.00000000000001256 75.0
SHD2_k127_4634029_15 cheY-homologous receiver domain - - - 0.00000000000001576 74.0
SHD2_k127_4634029_2 Domain of unknown function (DUF4398) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 304.0
SHD2_k127_4634029_3 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009291 257.0
SHD2_k127_4634029_4 alginic acid biosynthetic process K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000001377 245.0
SHD2_k127_4634029_5 Evidence 4 Homologs of previously reported genes of K09700 - - 0.0000000000000000000000000000000001616 134.0
SHD2_k127_4634029_6 BON domain - - - 0.0000000000000000000000000000000005819 133.0
SHD2_k127_4634029_7 Bacterial protein of unknown function (DUF883) - - - 0.00000000000000000000000000000001247 129.0
SHD2_k127_4634029_8 Domain of unknown function (DUF4398) - - - 0.0000000000000000000000000014 116.0
SHD2_k127_4634029_9 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000000000000000002451 115.0
SHD2_k127_4642639_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 2.432e-256 795.0
SHD2_k127_4642639_1 PFAM type II and III secretion system protein K02453,K12282 - - 1.487e-208 662.0
SHD2_k127_4642639_10 Fimbrial assembly protein (PilN) - - - 0.000000000000000000000000000000000000000000000000000000000725 211.0
SHD2_k127_4642639_11 carbon utilization K12280 - - 0.00000000000000000000000000000000000000000000000000000000861 211.0
SHD2_k127_4642639_12 PFAM GCN5-related N-acetyltransferase K22441 - 2.3.1.57 0.00000000000000000000000000000000000000000000000000002221 194.0
SHD2_k127_4642639_13 NifQ K15790 - - 0.0000000000000000000000000000000000000000008586 165.0
SHD2_k127_4642639_14 Ferredoxin III, nif-specific - - - 0.000000000000000000000000000000000000000004167 161.0
SHD2_k127_4642639_15 transport system periplasmic component K01989 - - 0.0000000000000000000000000000003025 132.0
SHD2_k127_4642639_16 Rop-like - - - 0.0000000000000000002448 89.0
SHD2_k127_4642639_17 - K12281 - - 0.0000000000000006015 86.0
SHD2_k127_4642639_2 Nitrogenase component 1 type Oxidoreductase K02592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 597.0
SHD2_k127_4642639_3 AAA domain K02450,K12283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 478.0
SHD2_k127_4642639_4 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 389.0
SHD2_k127_4642639_5 Pilus assembly protein K12279 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005604 361.0
SHD2_k127_4642639_6 Dinitrogenase reductase K05951 - 2.4.2.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 343.0
SHD2_k127_4642639_7 Protein of unknown function, DUF269 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001661 237.0
SHD2_k127_4642639_8 Tetratricopeptide repeat K12284 - - 0.00000000000000000000000000000000000000000000000000000000000000002873 241.0
SHD2_k127_4642639_9 Nitrogen fixation protein NifX K02596 - - 0.00000000000000000000000000000000000000000000000000000000000000005574 226.0
SHD2_k127_4668638_0 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 4.298e-262 822.0
SHD2_k127_4668638_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 9.1e-258 803.0
SHD2_k127_4668638_2 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 501.0
SHD2_k127_4668638_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000006705 228.0
SHD2_k127_4668638_4 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.00000000000000000000000000000000000000000000000109 179.0
SHD2_k127_4668638_5 PFAM CutA1 divalent ion tolerance protein K03926 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000003228 154.0
SHD2_k127_4668638_6 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000336 77.0
SHD2_k127_4704340_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 557.0
SHD2_k127_4704340_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 436.0
SHD2_k127_4704340_2 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.0000000000000000000758 90.0
SHD2_k127_4714908_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 3.304e-203 636.0
SHD2_k127_4714908_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 465.0
SHD2_k127_4714908_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001879 267.0
SHD2_k127_4714908_3 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009399 267.0
SHD2_k127_4714908_4 Helix-turn-helix domain K15539 - - 0.0000000000000000000000000000000000000000000131 175.0
SHD2_k127_4714908_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000003477 64.0
SHD2_k127_4774352_0 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006696 524.0
SHD2_k127_4774352_1 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 342.0
SHD2_k127_4774352_2 Acetyltransferase (GNAT) family K06977 GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000004121 205.0
SHD2_k127_4774352_3 isochorismatase, hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000796 208.0
SHD2_k127_4781644_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 600.0
SHD2_k127_4781644_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 529.0
SHD2_k127_4781644_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 287.0
SHD2_k127_4781644_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001658 279.0
SHD2_k127_4781644_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006168 238.0
SHD2_k127_4781644_5 Required for insertion of 4Fe-4S clusters K15724 - - 0.0000000000000000000000000000000000000000000000000000000000000001018 223.0
SHD2_k127_4781644_6 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000000000000006569 186.0
SHD2_k127_4798696_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 1.944e-217 684.0
SHD2_k127_4804386_0 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 559.0
SHD2_k127_4804386_1 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 326.0
SHD2_k127_4804386_2 PFAM binding-protein-dependent transport systems inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000108 214.0
SHD2_k127_4804386_3 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000001629 154.0
SHD2_k127_4804386_4 Tautomerase enzyme - - - 0.0000000000000000000000000000000000003086 144.0
SHD2_k127_4804386_5 Thioredoxin K05838 - - 0.000000000000000004974 84.0
SHD2_k127_482856_0 PFAM Cytochrome C K04561 - 1.7.2.5 1.545e-314 981.0
SHD2_k127_482856_1 Soluble lytic murein transglycosylase L domain K08309 - - 1.905e-241 763.0
SHD2_k127_482856_2 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 1.183e-232 725.0
SHD2_k127_482856_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 554.0
SHD2_k127_482856_4 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 334.0
SHD2_k127_482856_5 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000074 251.0
SHD2_k127_482856_6 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002649 244.0
SHD2_k127_482856_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000336 188.0
SHD2_k127_482856_8 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A - - - 0.0000000000000000000000000000000007559 134.0
SHD2_k127_482856_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K03793 - 1.5.1.33 0.000000000000000001677 87.0
SHD2_k127_4841771_0 CoA-binding domain protein K09181 - - 0.0 1487.0
SHD2_k127_4841771_1 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K18005 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 1.128e-317 976.0
SHD2_k127_4841771_10 Protein of unknown function (DUF1272) K09984 - - 0.00000000000000000000000000000000004008 136.0
SHD2_k127_4841771_11 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000001232 113.0
SHD2_k127_4841771_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 1.348e-299 922.0
SHD2_k127_4841771_3 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K18006 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 402.0
SHD2_k127_4841771_4 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K18007 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 362.0
SHD2_k127_4841771_5 CBS domain containing protein K07168 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004322 273.0
SHD2_k127_4841771_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005715 272.0
SHD2_k127_4841771_7 Regulatory protein MarR - - - 0.0000000000000000000000000000000000000000000000000000000000002647 214.0
SHD2_k127_4841771_8 DsrC like protein K11179 - - 0.00000000000000000000000000000000000000000000008119 171.0
SHD2_k127_4841771_9 maturation - - - 0.0000000000000000000000000000000000000000000006574 171.0
SHD2_k127_4847545_0 TonB-dependent Receptor Plug Domain K02014 - - 5.77e-221 708.0
SHD2_k127_4847545_1 DAHP synthetase I family K03856 - 2.5.1.54 1.704e-213 668.0
SHD2_k127_4847545_10 Domain of unknown function (DUF1841) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003283 264.0
SHD2_k127_4847545_11 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000000000004861 198.0
SHD2_k127_4847545_12 endonuclease K07451 - - 0.000000000000000000000000000000000000004457 149.0
SHD2_k127_4847545_13 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000000000000279 145.0
SHD2_k127_4847545_14 Copper chaperone PCu(A)C K09796 - - 0.0000000000000000000000000000003443 130.0
SHD2_k127_4847545_15 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000004066 71.0
SHD2_k127_4847545_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 605.0
SHD2_k127_4847545_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 548.0
SHD2_k127_4847545_4 PFAM ATP-binding region ATPase domain protein K15011 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 536.0
SHD2_k127_4847545_5 Bacterial regulatory proteins, tetR family K05501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 333.0
SHD2_k127_4847545_6 HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 327.0
SHD2_k127_4847545_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 329.0
SHD2_k127_4847545_8 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001673 276.0
SHD2_k127_4847545_9 Bacterial regulatory protein, Fis family K15012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000109 274.0
SHD2_k127_4907539_0 alpha-glucan phosphorylase K00688 - 2.4.1.1 0.0 1437.0
SHD2_k127_4907539_1 Alcohol dehydrogenase GroES-like domain K00001,K18369 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 536.0
SHD2_k127_4907539_2 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 403.0
SHD2_k127_4907539_3 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 365.0
SHD2_k127_4907539_4 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008001 367.0
SHD2_k127_4907539_5 SpoIIAA-like - - - 0.000000000000000000000000000000000000000000000000000000000006344 209.0
SHD2_k127_4907539_6 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000005393 116.0
SHD2_k127_4907539_7 Integrase core domain - - - 0.000000001235 61.0
SHD2_k127_4929127_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 1.334e-315 976.0
SHD2_k127_4929127_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 439.0
SHD2_k127_4929127_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009939 376.0
SHD2_k127_4929127_3 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 287.0
SHD2_k127_4929127_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002261 251.0
SHD2_k127_4929127_5 CRS1_YhbY K07574 - - 0.00000000000000000000000000000000000003735 149.0
SHD2_k127_4961927_0 Spermidine synthase K00797 - 2.5.1.16 7.776e-284 896.0
SHD2_k127_4961927_1 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 602.0
SHD2_k127_4961927_10 - - - - 0.0000000000000000000000006509 108.0
SHD2_k127_4961927_11 - K06950 - - 0.000000000000000001214 89.0
SHD2_k127_4961927_12 - - - - 0.000000001079 63.0
SHD2_k127_4961927_2 4 iron, 4 sulfur cluster binding K02574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 566.0
SHD2_k127_4961927_3 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 525.0
SHD2_k127_4961927_4 Sulfatase-modifying factor enzyme 1 K20333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 494.0
SHD2_k127_4961927_5 Cytochrome C and Quinol oxidase polypeptide I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005981 241.0
SHD2_k127_4961927_6 - - - - 0.00000000000000000000000000000000000000000000004114 173.0
SHD2_k127_4961927_7 - - - - 0.0000000000000000000000000000000000000000000001068 171.0
SHD2_k127_4961927_8 Cytochrome c - - - 0.00000000000000000000000000000000000000000001777 163.0
SHD2_k127_4961927_9 - - - - 0.000000000000000000000000107 113.0
SHD2_k127_4997113_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 1.174e-250 779.0
SHD2_k127_4997113_1 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 584.0
SHD2_k127_4997113_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 551.0
SHD2_k127_4997113_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 507.0
SHD2_k127_4997113_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007799 400.0
SHD2_k127_5032428_0 Catalyzes the synthesis of activated sulfate K00860,K00955,K00958 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 328.0
SHD2_k127_5032428_1 PFAM polysaccharide export protein K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 302.0
SHD2_k127_5032428_2 TIGRFAM exopolysaccharide transport protein family K16692 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000003934 240.0
SHD2_k127_5032428_3 Low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000001918 174.0
SHD2_k127_5057555_0 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 396.0
SHD2_k127_5057555_1 Beta-ketoacyl synthase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 359.0
SHD2_k127_5057555_2 Beta-ketoacyl synthase, C-terminal domain K00647,K09458 - 2.3.1.179,2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000007364 263.0
SHD2_k127_5057555_3 dehydratase - - - 0.00000000000000000000000000000000000000000000000000008182 191.0
SHD2_k127_5058289_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1167.0
SHD2_k127_5058289_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 1.77e-208 652.0
SHD2_k127_5058289_2 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 326.0
SHD2_k127_5058289_3 NUDIX domain K08310 - 3.6.1.67 0.0000000000000000000000000000000000000000000000000000000000000000017 229.0
SHD2_k127_5058289_4 PFAM guanine-specific ribonuclease N1 and T1 K01167 - 3.1.27.3 0.000000000000000000000000000000000000000000000003933 175.0
SHD2_k127_5058289_5 Barstar (barnase inhibitor) - - - 0.000000000000000000000000000000000000000001212 159.0
SHD2_k127_5058289_6 Regulatory protein, FmdB family - - - 0.0000000000000000000000000000000004033 132.0
SHD2_k127_5058352_0 TIGRFAM type I secretion outer membrane protein, TolC family K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 594.0
SHD2_k127_5058352_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 546.0
SHD2_k127_5058352_2 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 396.0
SHD2_k127_5058352_3 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 313.0
SHD2_k127_5058352_4 - - - - 0.000000000211 61.0
SHD2_k127_5089935_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 431.0
SHD2_k127_5089935_1 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 344.0
SHD2_k127_5089935_2 3'-5' exonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009047 312.0
SHD2_k127_5089935_3 - - - - 0.0000000000000000000000000000000001395 137.0
SHD2_k127_511333_0 Diguanylate cyclase (GGDEF) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 486.0
SHD2_k127_5117261_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 617.0
SHD2_k127_5117261_1 Integrase core domain - - - 0.000000000000001529 76.0
SHD2_k127_5117261_2 Transposase K07487 - - 0.0000006418 51.0
SHD2_k127_5145587_0 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 464.0
SHD2_k127_5145587_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 366.0
SHD2_k127_5145587_2 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000117 185.0
SHD2_k127_5145587_3 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000000000000001173 146.0
SHD2_k127_5145587_4 beta-lactamase activity K07126 - - 0.00000000000000007705 84.0
SHD2_k127_5162900_0 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 3.815e-222 691.0
SHD2_k127_5162900_1 Sporulation related domain - - - 0.000000000000000000000000000000000006545 146.0
SHD2_k127_5162900_2 DSBA-like thioredoxin domain K03673 - - 0.00000000000000000000000003529 109.0
SHD2_k127_5164894_0 SEFIR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 402.0
SHD2_k127_5164894_1 Belongs to the pseudouridine synthase RsuA family K06182 - 5.4.99.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 334.0
SHD2_k127_5164894_2 PFAM type II secretion system protein E K02670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002425 242.0
SHD2_k127_5164894_3 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10111 - - 0.000000000000000000000000000000000000000000000000114 184.0
SHD2_k127_5164894_4 DNA-binding protein VF530 - - - 0.0000000000000000000000000006567 113.0
SHD2_k127_519382_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 9.245e-251 777.0
SHD2_k127_519382_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 436.0
SHD2_k127_519382_2 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 320.0
SHD2_k127_519382_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000002457 117.0
SHD2_k127_519382_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000002691 72.0
SHD2_k127_519602_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.0 1245.0
SHD2_k127_519602_1 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 475.0
SHD2_k127_519602_2 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 395.0
SHD2_k127_519602_3 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 312.0
SHD2_k127_519602_4 - - - - 0.000000000000000000000000000000000001439 141.0
SHD2_k127_519602_5 - - - - 0.0000000000000000000000000000000002898 138.0
SHD2_k127_519602_6 Flagellar regulator YcgR - - - 0.0000000000007212 78.0
SHD2_k127_5214017_0 The glycine cleavage system catalyzes the degradation of glycine K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 2.906e-219 683.0
SHD2_k127_5214017_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 1.148e-200 634.0
SHD2_k127_5214017_2 Epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 341.0
SHD2_k127_5214017_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000000000000000000244 223.0
SHD2_k127_5214017_4 Protein of unknown function (DUF3426) - - - 0.000000000000000000000000000000000000000000000000000000000009917 214.0
SHD2_k127_5214017_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000001077 175.0
SHD2_k127_5225267_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 2.572e-295 910.0
SHD2_k127_5225267_1 Peptidase family M23 K08259 - 3.4.24.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 322.0
SHD2_k127_5225267_2 Protein of unknown function (DUF721) - - - 0.00000000000002505 78.0
SHD2_k127_5225267_3 - - - - 0.0000000000008461 70.0
SHD2_k127_5283157_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 2.423e-315 973.0
SHD2_k127_5283157_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 537.0
SHD2_k127_5283157_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000005969 166.0
SHD2_k127_5283157_3 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000000000000000000006941 159.0
SHD2_k127_5283157_4 SNARE associated Golgi protein K03975 - - 0.000000000000000001933 87.0
SHD2_k127_5295024_0 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 602.0
SHD2_k127_5295024_1 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000059 213.0
SHD2_k127_5295024_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000001421 185.0
SHD2_k127_5295024_3 Diguanylate cyclase - - - 0.0000000000000000000000000000000000002234 143.0
SHD2_k127_5296945_0 Nitrogenase cofactor biosynthesis protein NifB K02585 - - 2.833e-276 856.0
SHD2_k127_5296945_1 Nif-specific regulatory protein K02584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 588.0
SHD2_k127_5296945_10 PFAM NifZ family protein K02597 - - 0.000000000000000000000000000419 115.0
SHD2_k127_5296945_11 NifT/FixU protein K02593 - - 0.000000000000000000000000001068 113.0
SHD2_k127_5296945_12 - - - - 0.00000006728 58.0
SHD2_k127_5296945_2 PFAM EAL domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 439.0
SHD2_k127_5296945_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 340.0
SHD2_k127_5296945_4 LRV protein FeS4 cluster - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001312 259.0
SHD2_k127_5296945_5 Iron-sulphur cluster biosynthesis - - - 0.000000000000000000000000000000000000003109 149.0
SHD2_k127_5296945_6 NifZ domain K02597 - - 0.00000000000000000000000000000000001683 137.0
SHD2_k127_5296945_7 4Fe-4S binding domain - - - 0.0000000000000000000000000000000002063 135.0
SHD2_k127_5296945_8 Protein of unknown function (DUF3024) - - - 0.00000000000000000000000000004792 123.0
SHD2_k127_5297244_0 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 1.043e-278 871.0
SHD2_k127_5297244_1 PFAM aminotransferase class I and II K14260 - 2.6.1.2,2.6.1.66 1.173e-249 773.0
SHD2_k127_5297244_10 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000001375 156.0
SHD2_k127_5297244_11 - - - - 0.0000000000001119 76.0
SHD2_k127_5297244_2 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 422.0
SHD2_k127_5297244_3 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 376.0
SHD2_k127_5297244_4 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 369.0
SHD2_k127_5297244_5 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 367.0
SHD2_k127_5297244_6 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 331.0
SHD2_k127_5297244_7 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005322 276.0
SHD2_k127_5297244_8 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.0000000000000000000000000000000000000000000000003924 181.0
SHD2_k127_5297244_9 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000000000000000000000007798 177.0
SHD2_k127_5305960_0 Sulfate permease family K03321 - - 1.309e-244 768.0
SHD2_k127_5305960_1 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 451.0
SHD2_k127_5305960_10 Transposase IS200 like - - - 0.00000000152 60.0
SHD2_k127_5305960_2 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 406.0
SHD2_k127_5305960_3 PFAM Integrase catalytic region K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 352.0
SHD2_k127_5305960_4 Transposase K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 326.0
SHD2_k127_5305960_5 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 302.0
SHD2_k127_5305960_6 Transposase K07483 - - 0.000000000000000000000000002632 115.0
SHD2_k127_5305960_7 - - - - 0.000000000000000000000000003401 113.0
SHD2_k127_5305960_8 ERAD pathway K17535 - 2.7.11.1 0.000000000000000000000006052 116.0
SHD2_k127_5305960_9 Transposase IS200 like - - - 0.00000000000000000001628 92.0
SHD2_k127_5330864_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 1.525e-196 617.0
SHD2_k127_5330864_1 PFAM ATP-binding region ATPase domain protein - - - 6.613e-195 628.0
SHD2_k127_5330864_2 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 481.0
SHD2_k127_5330864_3 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 334.0
SHD2_k127_5330864_4 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 311.0
SHD2_k127_5330864_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 296.0
SHD2_k127_5330864_6 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters K02170 - 3.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000003332 246.0
SHD2_k127_5330864_7 PFAM electron transport protein SCO1 SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000002528 217.0
SHD2_k127_5330864_8 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000002033 153.0
SHD2_k127_5341916_0 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008418 443.0
SHD2_k127_5379510_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1039.0
SHD2_k127_5379510_1 TIGRFAM glutamate synthase, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 3.395e-300 922.0
SHD2_k127_5379510_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 1.865e-226 702.0
SHD2_k127_5379510_3 Cytochrome b(N-terminal)/b6/petB K00412 - - 2.066e-225 702.0
SHD2_k127_5379510_4 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 283.0
SHD2_k127_5379510_5 Cytochrome C1 family K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001132 274.0
SHD2_k127_5379510_6 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0000000000000000000000005118 104.0
SHD2_k127_5384765_0 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 410.0
SHD2_k127_5384765_1 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007681 407.0
SHD2_k127_5384765_2 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 289.0
SHD2_k127_5427337_0 fibronectin type III domain protein K06882 - - 0.0 1305.0
SHD2_k127_5427337_1 CHASE2 K01768 - 4.6.1.1 2.87e-302 936.0
SHD2_k127_5427337_2 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 2.669e-289 903.0
SHD2_k127_5427337_3 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008678 488.0
SHD2_k127_5427337_4 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 385.0
SHD2_k127_5427337_5 MlaA lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 297.0
SHD2_k127_5427337_6 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000002549 241.0
SHD2_k127_5427337_7 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000234 155.0
SHD2_k127_5427337_8 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000923 128.0
SHD2_k127_5447187_0 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 396.0
SHD2_k127_5447187_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009818 348.0
SHD2_k127_5447187_2 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000001644 245.0
SHD2_k127_5447187_3 Protein of unknown function (DUF559) - - - 0.00000000000000000000000002534 109.0
SHD2_k127_5455597_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 1.797e-288 886.0
SHD2_k127_5455597_1 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 469.0
SHD2_k127_5455597_2 Peptidase family U32 C-terminal domain K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008564 264.0
SHD2_k127_5455597_3 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000000000000000000000000000007812 175.0
SHD2_k127_5455597_4 HD domain K01139 - 2.7.6.5,3.1.7.2 0.0000000000000000000000000000000000000000000006338 173.0
SHD2_k127_5462862_0 Binding-protein-dependent transport system inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 302.0
SHD2_k127_5462862_1 Bacterial extracellular solute-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 297.0
SHD2_k127_5462862_2 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02019 - - 0.000000000000000000000000000000000005085 143.0
SHD2_k127_5462862_3 Protein of unknown function (DUF559) K07316 - 2.1.1.72 0.0000000000000000000000000000008391 126.0
SHD2_k127_5474081_0 Sugar (and other) transporter - - - 2.222e-237 739.0
SHD2_k127_5474081_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 480.0
SHD2_k127_5474081_2 PFAM Appr-1-p processing domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 291.0
SHD2_k127_5474081_3 - - - - 0.000000000000000000000000000000000000000000000000000000000001901 211.0
SHD2_k127_5474081_4 - - - - 0.0000000000000000000000000004958 121.0
SHD2_k127_5474081_5 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000001835 102.0
SHD2_k127_5474081_6 TRANSCRIPTIONal - - - 0.0000000000000000000000721 99.0
SHD2_k127_5476555_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 4.645e-252 780.0
SHD2_k127_5476555_1 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 540.0
SHD2_k127_5476555_2 pfkB family carbohydrate kinase K03272,K21344 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 467.0
SHD2_k127_5476555_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 340.0
SHD2_k127_5476555_4 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.00000000000000000000000000000000000000000000001188 171.0
SHD2_k127_5492200_0 K+ potassium transporter K03549 - - 2.071e-257 807.0
SHD2_k127_5492200_1 von Willebrand factor, type A - - - 4.093e-200 640.0
SHD2_k127_5492200_10 PFAM response regulator receiver K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002487 280.0
SHD2_k127_5492200_11 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000411 261.0
SHD2_k127_5492200_12 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000003107 128.0
SHD2_k127_5492200_13 - - - - 0.00000007755 59.0
SHD2_k127_5492200_2 phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 581.0
SHD2_k127_5492200_3 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 492.0
SHD2_k127_5492200_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 425.0
SHD2_k127_5492200_5 Zinc-uptake complex component A periplasmic K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 418.0
SHD2_k127_5492200_6 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 372.0
SHD2_k127_5492200_7 ABC 3 transport family K02075 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007619 327.0
SHD2_k127_5492200_8 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 332.0
SHD2_k127_5492200_9 Caspase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001656 289.0
SHD2_k127_5503308_0 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.0 1043.0
SHD2_k127_5503308_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 0.0 1030.0
SHD2_k127_5503308_2 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 463.0
SHD2_k127_5503308_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004372 288.0
SHD2_k127_5503308_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000003595 224.0
SHD2_k127_5516027_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 584.0
SHD2_k127_5516027_1 Rhodanese Homology Domain K06917 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 366.0
SHD2_k127_5516027_2 - - - - 0.000000000000000000002863 96.0
SHD2_k127_5516309_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 8.536e-241 750.0
SHD2_k127_5516309_1 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 313.0
SHD2_k127_5516309_2 Chemoreceptor zinc-binding domain - - - 0.0000000000000000000000000000000000000000000009311 169.0
SHD2_k127_5524574_0 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 579.0
SHD2_k127_5524574_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 588.0
SHD2_k127_5524574_2 S4 RNA-binding domain K06182 - 5.4.99.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008449 399.0
SHD2_k127_5524574_3 UPF0056 inner membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 305.0
SHD2_k127_5524574_4 PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 0.000000000000000000000000000000000000000000000000000000000000000002496 228.0
SHD2_k127_5524574_5 PFAM Excinuclease ABC C subunit domain protein K07461 - - 0.00000000000000000000000000000000002828 137.0
SHD2_k127_5524574_6 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000004482 113.0
SHD2_k127_5539654_0 serine threonine protein kinase K12132 - 2.7.11.1 0.0 1286.0
SHD2_k127_5539654_1 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0 1028.0
SHD2_k127_5539654_2 cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 424.0
SHD2_k127_5539654_3 SMART beta-lactamase domain protein K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 408.0
SHD2_k127_5539654_4 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 401.0
SHD2_k127_5539654_5 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 343.0
SHD2_k127_5539654_6 General secretory system II protein E domain protein K02454,K02652,K12276 - - 0.0000000000000000000000000000000000000000000000000000001289 196.0
SHD2_k127_5560775_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006855 383.0
SHD2_k127_5560775_1 DSBA-like thioredoxin domain K03673 - - 0.00000000000000000000000000000000000000000000000000000000000000000004721 235.0
SHD2_k127_5560775_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172,K18357 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000001583 156.0
SHD2_k127_5564954_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772,K03815 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 516.0
SHD2_k127_5564954_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 393.0
SHD2_k127_5564954_2 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 332.0
SHD2_k127_5564954_3 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000001079 243.0
SHD2_k127_5564954_4 Uracil DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000306 234.0
SHD2_k127_5577898_0 B12 binding domain - - - 0.0 1024.0
SHD2_k127_5577898_1 MMPL family - - - 0.0 1012.0
SHD2_k127_5577898_10 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 412.0
SHD2_k127_5577898_11 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006506 399.0
SHD2_k127_5577898_12 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 395.0
SHD2_k127_5577898_13 Bacterial lipid A biosynthesis acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 389.0
SHD2_k127_5577898_14 MltA-interacting protein MipA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 372.0
SHD2_k127_5577898_15 Domain of unknown function (DUF4872) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 366.0
SHD2_k127_5577898_16 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 362.0
SHD2_k127_5577898_17 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 333.0
SHD2_k127_5577898_18 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001252 272.0
SHD2_k127_5577898_19 Serine hydrolase involved in the detoxification of formaldehyde - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002489 257.0
SHD2_k127_5577898_2 Beta-lactamase - - - 5.484e-298 922.0
SHD2_k127_5577898_20 MarR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001836 244.0
SHD2_k127_5577898_21 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000003279 209.0
SHD2_k127_5577898_22 OmpA family K03640 - - 0.00000000000000000000000000000000000000000000002406 174.0
SHD2_k127_5577898_23 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000000000006862 146.0
SHD2_k127_5577898_24 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000000000000000001084 149.0
SHD2_k127_5577898_25 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000006337 128.0
SHD2_k127_5577898_26 FabA-like domain - - - 0.000000000000000000000000005599 113.0
SHD2_k127_5577898_27 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000001857 113.0
SHD2_k127_5577898_3 fad dependent oxidoreductase - - - 2.36e-219 686.0
SHD2_k127_5577898_4 Sodium/hydrogen exchanger family - - - 6.608e-214 669.0
SHD2_k127_5577898_5 Chloride channel - - - 2.965e-210 660.0
SHD2_k127_5577898_6 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 597.0
SHD2_k127_5577898_7 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 511.0
SHD2_k127_5577898_8 pteridine-dependent deoxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 436.0
SHD2_k127_5577898_9 Glycosyl transferase family 2 K00786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 432.0
SHD2_k127_5595285_0 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 486.0
SHD2_k127_5595285_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009565 482.0
SHD2_k127_5595285_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 456.0
SHD2_k127_5595285_3 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 396.0
SHD2_k127_5595285_4 cyclic nucleotide binding K01420 - - 0.00000000000000000000000000004356 118.0
SHD2_k127_5595285_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000002107 107.0
SHD2_k127_5825703_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000661 267.0
SHD2_k127_5825703_3 LPP20 lipoprotein - - - 0.0000000000000000000000000000000000000000000000001492 184.0
SHD2_k127_5825703_4 FecR protein - - - 0.000000000007786 75.0
SHD2_k127_5835422_0 fad dependent oxidoreductase - - - 1.864e-253 785.0
SHD2_k127_5835422_1 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000322 242.0
SHD2_k127_5835422_2 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000008776 213.0
SHD2_k127_5840517_0 fad dependent oxidoreductase K07137 - - 1.024e-208 652.0
SHD2_k127_5840517_1 Diguanylate cyclase (GGDEF) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 347.0
SHD2_k127_5878714_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 3.473e-240 743.0
SHD2_k127_5878714_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001566 248.0
SHD2_k127_5894745_0 Beta-ketoacyl synthase, C-terminal domain K09458,K14660 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 1.748e-206 648.0
SHD2_k127_5894745_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 558.0
SHD2_k127_5894745_2 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008803 518.0
SHD2_k127_5894745_3 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 410.0
SHD2_k127_5894745_4 Phosphopantetheine attachment site K02078 - - 0.0000000000000000000000000000000966 125.0
SHD2_k127_6005241_0 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 545.0
SHD2_k127_6005241_1 Glycosyl transferase family 2 K10012 - 2.4.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009601 386.0
SHD2_k127_6005241_2 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003815 271.0
SHD2_k127_604939_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 1.204e-230 718.0
SHD2_k127_604939_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 580.0
SHD2_k127_604939_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 510.0
SHD2_k127_604939_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 324.0
SHD2_k127_604939_4 POTRA domain, FtsQ-type - - - 0.000000000000000000000000000000000000000000000003311 181.0
SHD2_k127_604939_5 - - - - 0.0009181 45.0
SHD2_k127_605666_0 RNB K01147 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 602.0
SHD2_k127_605666_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005969 576.0
SHD2_k127_605666_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 310.0
SHD2_k127_605666_3 Spore Coat Protein U domain - - - 0.000000000000000000000000000000000364 142.0
SHD2_k127_605666_4 Cytochrome C oxidase, cbb3-type, subunit III K08738 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000001957 124.0
SHD2_k127_605666_5 SMART Calcium-binding EF-hand-containing protein - - - 0.00000000000000000000000000002788 125.0
SHD2_k127_6072940_0 PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 534.0
SHD2_k127_6072940_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008182 471.0
SHD2_k127_6087899_0 PFAM CHASE2 domain - - - 4.069e-261 814.0
SHD2_k127_6087899_1 Oxidoreductase FAD-binding domain protein K00523,K18248 - 1.17.1.1 6.203e-202 640.0
SHD2_k127_6087899_2 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 374.0
SHD2_k127_6087899_3 Domain of unknown function (DUF4382) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 367.0
SHD2_k127_6087899_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004678 279.0
SHD2_k127_6087899_5 Bacterial SH3 domain - - - 0.0000000000000000000000000000000000000000000000000125 185.0
SHD2_k127_6087899_6 Hydrogenase formation hypA family K04654 GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - 0.000000000000000000000004044 101.0
SHD2_k127_6092282_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 2.985e-244 760.0
SHD2_k127_6092282_1 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 337.0
SHD2_k127_6092282_2 Beta-ketoacyl synthase, C-terminal domain K00647,K09458 - 2.3.1.179,2.3.1.41 0.0000000000000000000000000003151 115.0
SHD2_k127_6275650_0 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 3.829e-213 673.0
SHD2_k127_6275650_1 Alpha/beta hydrolase family K03928 - 3.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 499.0
SHD2_k127_6275650_2 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 346.0
SHD2_k127_6275650_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000001255 139.0
SHD2_k127_6275650_4 antisigma factor binding K04749 - - 0.00000000000000000000000002335 112.0
SHD2_k127_6304567_0 Histidine Phosphotransfer domain - - - 1.478e-215 723.0
SHD2_k127_6304567_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 543.0
SHD2_k127_6304567_2 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000757 246.0
SHD2_k127_6304567_3 Paraquat-inducible protein A - - - 0.00000000000000000000000000000000000000000000000000000000000000000007179 247.0
SHD2_k127_6304567_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000004959 233.0
SHD2_k127_6304567_5 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.0000000000000000000000000000000000000000000000000003572 185.0
SHD2_k127_6304567_6 transport system periplasmic component K01989 - - 0.00000000000000000000000000000004047 128.0
SHD2_k127_6316184_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 585.0
SHD2_k127_6316184_1 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 537.0
SHD2_k127_6316184_2 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 490.0
SHD2_k127_6316184_3 Peptidyl-prolyl cis-trans isomerase K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000413 263.0
SHD2_k127_6316184_4 Bacterial protein of unknown function (DUF899) K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000126 255.0
SHD2_k127_6316184_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000033 224.0
SHD2_k127_6316184_6 VirC1 protein K03496 - - 0.00000000000000000000000000000000000000000000004389 179.0
SHD2_k127_6345563_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K18138 - - 0.0 1592.0
SHD2_k127_6345563_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 608.0
SHD2_k127_6345563_2 LysM domain K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 515.0
SHD2_k127_6345563_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 482.0
SHD2_k127_6345563_4 MltA-interacting MipA family protein K07274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 340.0
SHD2_k127_6345563_5 PFAM Hemerythrin HHE cation binding domain K07216 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002981 258.0
SHD2_k127_6345563_6 SpoIIAA-like - - - 0.000000000000000000000000000000000000000000000000000001142 193.0
SHD2_k127_6345563_7 Transcriptional regulator K07782,K15852,K19666,K19734 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010564,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032465,GO:0032467,GO:0032991,GO:0032993,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045787,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051302,GO:0051726,GO:0051781,GO:0060255,GO:0065007,GO:0080090,GO:0090068,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000000000000000000000000000000000000000000000000004984 198.0
SHD2_k127_6345563_8 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000006151 196.0
SHD2_k127_6354706_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 3.705e-202 632.0
SHD2_k127_6354706_1 Chorismate mutase type II K01713,K14170 - 4.2.1.51,4.2.1.91,5.4.99.5 2.146e-196 615.0
SHD2_k127_6354706_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 576.0
SHD2_k127_6354706_3 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 400.0
SHD2_k127_6354706_4 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000002145 177.0
SHD2_k127_6355623_0 PFAM glycosyl transferase family 39 - - - 3.293e-210 667.0
SHD2_k127_6355623_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009539 576.0
SHD2_k127_6355623_2 BNR repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 517.0
SHD2_k127_6355623_3 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 468.0
SHD2_k127_6355623_4 dTDP-glucose 4-6-dehydratase K01710,K01784 - 4.2.1.46,5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 318.0
SHD2_k127_6355623_5 - - - - 0.00000000000000000000000000000000000000000003207 170.0
SHD2_k127_6359049_0 Histidine kinase K07673 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 317.0
SHD2_k127_6359049_1 helix_turn_helix, Lux Regulon K07684 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 293.0
SHD2_k127_6359049_10 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000001731 55.0
SHD2_k127_6359049_11 Glucose inhibited division protein A K03388,K16885 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0001273 45.0
SHD2_k127_6359049_2 rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000137 259.0
SHD2_k127_6359049_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000000000000000000168 209.0
SHD2_k127_6359049_4 KAP family P-loop domain - - - 0.00000000000000000000000000000000000009164 147.0
SHD2_k127_6359049_5 PFAM Uncharacterised conserved protein UCP030820 - - - 0.00000000000000000000000000000000001305 142.0
SHD2_k127_6359049_6 Protein conserved in bacteria K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000001801 123.0
SHD2_k127_6359049_7 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000154 112.0
SHD2_k127_6359049_8 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000001629 64.0
SHD2_k127_6359049_9 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000009374 59.0
SHD2_k127_6373329_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 4.763e-203 639.0
SHD2_k127_6373329_1 serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 506.0
SHD2_k127_6373329_2 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 447.0
SHD2_k127_6373329_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003355 267.0
SHD2_k127_6373329_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000006983 226.0
SHD2_k127_6373329_5 photosynthesis K12132,K20543 - 2.7.11.1 0.00000000000000000000000000000000000000000000000005452 183.0
SHD2_k127_6373329_6 - - - - 0.0000000000000000000000000000000000000000000003951 170.0
SHD2_k127_6373329_8 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000007211 143.0
SHD2_k127_6376056_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 473.0
SHD2_k127_6376056_1 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 469.0
SHD2_k127_6376056_10 Phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000000000000000000001909 164.0
SHD2_k127_6376056_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000000001301 121.0
SHD2_k127_6376056_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000000003688 109.0
SHD2_k127_6376056_13 PFAM peptidase S1 and S6 chymotrypsin Hap K04691,K04772 - - 0.000000000000112 71.0
SHD2_k127_6376056_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 386.0
SHD2_k127_6376056_3 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 357.0
SHD2_k127_6376056_4 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 346.0
SHD2_k127_6376056_5 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 314.0
SHD2_k127_6376056_7 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000002464 240.0
SHD2_k127_6376056_8 HIT domain K02503 - - 0.000000000000000000000000000000000000000000000000000000001455 203.0
SHD2_k127_6376056_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000001564 164.0
SHD2_k127_6393133_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.0 1197.0
SHD2_k127_6393133_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 7.527e-275 845.0
SHD2_k127_6393133_10 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000000000000000003239 140.0
SHD2_k127_6393133_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 5.279e-261 806.0
SHD2_k127_6393133_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 527.0
SHD2_k127_6393133_4 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 511.0
SHD2_k127_6393133_5 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 393.0
SHD2_k127_6393133_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 327.0
SHD2_k127_6393133_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 292.0
SHD2_k127_6393133_8 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000171 267.0
SHD2_k127_6393133_9 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000001386 211.0
SHD2_k127_6401834_0 THUMP K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 599.0
SHD2_k127_6401834_1 PFAM ABC transporter related K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 508.0
SHD2_k127_6401834_2 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 443.0
SHD2_k127_6401834_3 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007977 407.0
SHD2_k127_6401834_4 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000003788 215.0
SHD2_k127_6401834_5 membrane K08973 - - 0.0000000000000000000000000000000000000000000000000000001959 196.0
SHD2_k127_6401834_6 Serine aminopeptidase, S33 K07018 - - 0.00000001244 55.0
SHD2_k127_6401834_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000101 59.0
SHD2_k127_6408198_0 Histidine Phosphotransfer domain K02487,K06596 - - 0.0 1717.0
SHD2_k127_6408198_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 6.696e-259 806.0
SHD2_k127_6408198_10 cheY-homologous receiver domain K02658 - - 0.00000000000000000000000000000000000000000000000000000003712 199.0
SHD2_k127_6408198_11 PFAM peptidase M3A and M3B thimet oligopeptidase F K01414 - 3.4.24.70 0.0000000002601 61.0
SHD2_k127_6408198_2 Amidohydrolase family K01465 - 3.5.2.3 8.966e-251 781.0
SHD2_k127_6408198_3 PFAM TrkA-N domain protein K03499 - - 1.735e-211 661.0
SHD2_k127_6408198_4 histidine kinase HAMP region domain protein K02660,K03406 - - 4.433e-203 652.0
SHD2_k127_6408198_5 PFAM aspartate ornithine carbamoyltransferase Asp Orn-binding region K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 578.0
SHD2_k127_6408198_6 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 314.0
SHD2_k127_6408198_7 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000000000000000000000000000000000003772 235.0
SHD2_k127_6408198_8 cheY-homologous receiver domain K02657 - - 0.000000000000000000000000000000000000000000000000000000000000001007 220.0
SHD2_k127_6408198_9 Two component signalling adaptor domain K02659 - - 0.0000000000000000000000000000000000000000000000000000000000005469 214.0
SHD2_k127_6429731_0 PFAM type II and III secretion system protein K02453 - - 7.997e-206 657.0
SHD2_k127_6429731_1 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 618.0
SHD2_k127_6429731_10 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000337 258.0
SHD2_k127_6429731_11 MlaC protein K07323 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001598 250.0
SHD2_k127_6429731_12 Belongs to the BolA IbaG family - - - 0.0000000000000000000000000001202 117.0
SHD2_k127_6429731_13 response to antibiotic K07122 - - 0.00000000000000000004171 93.0
SHD2_k127_6429731_2 General secretory system II protein E domain protein K02454,K02652,K12276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 562.0
SHD2_k127_6429731_3 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000858 504.0
SHD2_k127_6429731_4 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 479.0
SHD2_k127_6429731_5 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 440.0
SHD2_k127_6429731_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 426.0
SHD2_k127_6429731_7 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 362.0
SHD2_k127_6429731_8 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000064 276.0
SHD2_k127_6429731_9 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000635 286.0
SHD2_k127_6433570_0 Glycosyl transferase family 21 K00694 - 2.4.1.12 1.815e-272 867.0
SHD2_k127_6433570_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001069 258.0
SHD2_k127_6433570_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000004089 187.0
SHD2_k127_6433570_3 cellulose synthase K20541 - - 0.0000000000000000000000000000000000000000167 161.0
SHD2_k127_6433570_4 Glycosyl hydrolases family 8 K20542 - 3.2.1.4 0.000000000000000000000000000000001341 136.0
SHD2_k127_6437170_0 Putative diguanylate phosphodiesterase - - - 8.135e-252 791.0
SHD2_k127_6437170_1 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 565.0
SHD2_k127_6437170_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004716 282.0
SHD2_k127_6437170_3 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000891 211.0
SHD2_k127_645041_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 9.692e-292 912.0
SHD2_k127_645041_1 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 556.0
SHD2_k127_645041_2 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 422.0
SHD2_k127_645041_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 299.0
SHD2_k127_6481930_0 PFAM secretion protein HlyD family protein K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 462.0
SHD2_k127_6481930_1 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007853 308.0
SHD2_k127_6481930_2 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 283.0
SHD2_k127_6481930_3 Transcription regulator that can specifically activate or repress expression of target genes K06075 - - 0.000000000000000000000000000000000000000000000003289 179.0
SHD2_k127_6481930_4 4Fe-4S single cluster domain - - - 0.00000000000000000000003287 99.0
SHD2_k127_6481930_5 major facilitator superfamily K03446 - - 0.00000000000008283 72.0
SHD2_k127_6508798_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 1.223e-212 664.0
SHD2_k127_6508798_1 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 570.0
SHD2_k127_6508798_2 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 471.0
SHD2_k127_6508798_3 PFAM MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 426.0
SHD2_k127_6508798_4 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000006697 148.0
SHD2_k127_6508798_5 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000008171 142.0
SHD2_k127_6508798_6 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000000000000000000528 103.0
SHD2_k127_6530668_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0 1010.0
SHD2_k127_6530668_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.5e-264 818.0
SHD2_k127_6530668_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 416.0
SHD2_k127_6530668_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 356.0
SHD2_k127_6530668_4 - - - - 0.0000000002734 64.0
SHD2_k127_6546619_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 9.873e-275 852.0
SHD2_k127_6546619_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 8.752e-260 801.0
SHD2_k127_6546619_10 Thioredoxin K03671 - - 0.000000000000000000000000000000000000000000000000000000000000005545 218.0
SHD2_k127_6546619_11 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 - 2.4.2.1,2.4.2.2 0.00000000000000000000000000000000000000000000000000000115 192.0
SHD2_k127_6546619_12 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000000007449 135.0
SHD2_k127_6546619_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.912e-254 786.0
SHD2_k127_6546619_3 PFAM aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 2.393e-206 647.0
SHD2_k127_6546619_4 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 593.0
SHD2_k127_6546619_5 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 502.0
SHD2_k127_6546619_6 SMART phosphoesterase PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 362.0
SHD2_k127_6546619_7 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 301.0
SHD2_k127_6546619_8 DJ-1/PfpI family K03152 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005262 271.0
SHD2_k127_6546619_9 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001024 240.0
SHD2_k127_6585468_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 1.268e-204 639.0
SHD2_k127_6585468_1 Involved in the TonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 603.0
SHD2_k127_6585468_10 TolA C-terminal K03646 - - 0.0000000000000000000000000000000000000000000001592 179.0
SHD2_k127_6585468_11 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 0.000000000000000000000000001328 112.0
SHD2_k127_6585468_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 460.0
SHD2_k127_6585468_3 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005054 353.0
SHD2_k127_6585468_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 303.0
SHD2_k127_6585468_5 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 291.0
SHD2_k127_6585468_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000006286 224.0
SHD2_k127_6585468_7 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000000000000000466 200.0
SHD2_k127_6585468_8 OmpA family K03640 - - 0.000000000000000000000000000000000000000000000000000001091 196.0
SHD2_k127_6585468_9 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000000000000000000000003681 190.0
SHD2_k127_6607722_0 SMART AAA ATPase K02450 - - 5.52e-254 792.0
SHD2_k127_6618962_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.944e-281 877.0
SHD2_k127_6618962_1 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 493.0
SHD2_k127_6618962_2 geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 447.0
SHD2_k127_6618962_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004187 243.0
SHD2_k127_6638764_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 559.0
SHD2_k127_6638764_1 Bacterial lipid A biosynthesis acyltransferase K02517,K12974 - 2.3.1.241,2.3.1.242 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009975 514.0
SHD2_k127_6638764_2 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007109 336.0
SHD2_k127_66677_0 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 536.0
SHD2_k127_66677_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 499.0
SHD2_k127_66677_2 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000002825 231.0
SHD2_k127_66677_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000000007039 207.0
SHD2_k127_66677_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000007693 171.0
SHD2_k127_66677_5 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K03286,K12976,K16079 - - 0.000000000000000001257 90.0
SHD2_k127_6672978_0 IS30 family K07482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 379.0
SHD2_k127_6672978_1 PFAM CcdB protein K19163 - - 0.00000000000000000000000000000000005557 139.0
SHD2_k127_6672978_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000002911 114.0
SHD2_k127_6672978_3 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid K19164 - - 0.0000000000000000000141 96.0
SHD2_k127_6682668_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 7.613e-211 659.0
SHD2_k127_6682668_1 PFAM aminotransferase class I and II K14267 - 2.6.1.17 6.427e-206 645.0
SHD2_k127_6682668_2 PFAM type II secretion system protein E K02670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 577.0
SHD2_k127_6682668_3 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 505.0
SHD2_k127_6682668_4 ArsC family K00537 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000001628 196.0
SHD2_k127_6682668_5 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.0000000000000000000000000000000000001184 142.0
SHD2_k127_6763440_0 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 413.0
SHD2_k127_6763440_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006172 259.0
SHD2_k127_6763440_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002026 228.0
SHD2_k127_6763440_3 membrane organization K20543 - - 0.0000000000000000000000000000000000000000000000000000000009248 218.0
SHD2_k127_6763440_4 - - - - 0.000000000000000000000000000000000000000000000000000000003276 203.0
SHD2_k127_6838764_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1081.0
SHD2_k127_6838764_1 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 507.0
SHD2_k127_6838764_2 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 396.0
SHD2_k127_6838764_3 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 291.0
SHD2_k127_6838764_4 PFAM Sporulation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001373 216.0
SHD2_k127_6838764_5 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000005399 192.0
SHD2_k127_6838764_6 - - - - 0.00000000000000000000000000008063 117.0
SHD2_k127_6838764_7 translation initiation factor activity - - - 0.000000000000000000000001825 107.0
SHD2_k127_6851443_0 GHMP kinases N terminal domain K01597 - 4.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000007895 247.0
SHD2_k127_6851443_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000003397 164.0
SHD2_k127_6851443_2 NmrA family - - - 0.0000000000000000000000000000000002021 144.0
SHD2_k127_6851443_3 ester cyclase - - - 0.0000000000000000000000001635 111.0
SHD2_k127_6857707_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1214.0
SHD2_k127_6857707_1 SMART adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 538.0
SHD2_k127_6857707_2 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 414.0
SHD2_k127_6857707_3 Phosphoglycolate phosphatase K22292 - 3.1.3.105 0.0000000000000000000000000000000000000000000000000000000000000000002083 235.0
SHD2_k127_6857707_4 TIGRFAM PAS sensor protein - - - 0.00000000000000000001934 106.0
SHD2_k127_6869025_0 Large family of predicted nucleotide-binding domains K07175 - - 2.896e-255 794.0
SHD2_k127_6869025_1 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 346.0
SHD2_k127_6869025_2 Lipase (class 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 287.0
SHD2_k127_6869025_3 Intracellular septation protein A K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002054 276.0
SHD2_k127_6869025_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000001424 248.0
SHD2_k127_6869025_5 Belongs to the MsrB Met sulfoxide reductase family K07305,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000001222 231.0
SHD2_k127_6869025_6 phospholipase K01058 - 3.1.1.32,3.1.1.4 0.000000000000000000000000000000000000000000000000000004362 202.0
SHD2_k127_6869025_7 Papain cysteine protease family protein - - - 0.0000000000000000000000000000000000000000001389 162.0
SHD2_k127_6869025_8 YCII-related domain K09780 - - 0.000000000000000000000000000000000000000006466 155.0
SHD2_k127_6869025_9 BolA-like protein K05527 - - 0.00000000000000000000002371 107.0
SHD2_k127_6870267_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1249.0
SHD2_k127_6870267_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 1.09e-266 823.0
SHD2_k127_6870267_2 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 433.0
SHD2_k127_6870267_3 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000002194 160.0
SHD2_k127_687557_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0 1021.0
SHD2_k127_687557_1 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008308 521.0
SHD2_k127_687557_2 serine threonine protein kinase - - - 0.0000000000000000000000000000001471 140.0
SHD2_k127_687557_3 FecR protein - - - 0.000000000000000000000000000002299 134.0
SHD2_k127_687557_4 Caspase domain - - - 0.0000000000001386 83.0
SHD2_k127_6905209_0 Required for chromosome condensation and partitioning K03529 - - 4.17e-271 846.0
SHD2_k127_6905209_1 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001046 280.0
SHD2_k127_6905209_2 Putative DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000001181 216.0
SHD2_k127_6905209_3 Plasmid stabilization system - - - 0.0000000000000000000009722 98.0
SHD2_k127_6905209_4 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.000001046 54.0
SHD2_k127_6911429_0 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 287.0
SHD2_k127_6911429_1 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000006512 189.0
SHD2_k127_6927716_0 PFAM FAD dependent oxidoreductase - - - 3.733e-258 802.0
SHD2_k127_6927716_1 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 361.0
SHD2_k127_6935729_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.33e-280 865.0
SHD2_k127_6935729_1 Required for chromosome condensation and partitioning K03529 - - 9.243e-259 808.0
SHD2_k127_6935729_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 472.0
SHD2_k127_6935729_5 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000001536 124.0
SHD2_k127_693645_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 9.78e-309 963.0
SHD2_k127_693645_1 PFAM major facilitator superfamily MFS_1 K08218 - - 4.894e-230 717.0
SHD2_k127_693645_10 rod shape-determining protein MreD K03571 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002001 262.0
SHD2_k127_693645_11 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000002592 108.0
SHD2_k127_693645_12 OmpA-like transmembrane domain K03286 - - 0.0000000000001315 78.0
SHD2_k127_693645_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 8.506e-222 692.0
SHD2_k127_693645_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 8.425e-197 623.0
SHD2_k127_693645_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 557.0
SHD2_k127_693645_5 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 431.0
SHD2_k127_693645_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 373.0
SHD2_k127_693645_7 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 367.0
SHD2_k127_693645_8 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005794 362.0
SHD2_k127_693645_9 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 321.0
SHD2_k127_70010_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 578.0
SHD2_k127_70010_1 Belongs to the HesB IscA family K13628 - - 0.000000000000000001563 84.0
SHD2_k127_7008628_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1002.0
SHD2_k127_7008628_1 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 346.0
SHD2_k127_7008628_2 Glycoprotease family K14742 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 295.0
SHD2_k127_7008628_3 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002184 272.0
SHD2_k127_7008628_4 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000002726 264.0
SHD2_k127_7008628_5 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789,K14742 - 2.3.1.128 0.0000000000000000000000000000000000000000001092 164.0
SHD2_k127_7025050_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 511.0
SHD2_k127_7025050_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 416.0
SHD2_k127_7025050_10 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000000000000000000000000000000001337 181.0
SHD2_k127_7025050_11 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000006511 178.0
SHD2_k127_7025050_12 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000000006683 149.0
SHD2_k127_7025050_13 elongation factor Tu K02358 - - 0.0000000000000000000000009237 103.0
SHD2_k127_7025050_14 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000002048 86.0
SHD2_k127_7025050_15 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000001211 60.0
SHD2_k127_7025050_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 362.0
SHD2_k127_7025050_3 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 361.0
SHD2_k127_7025050_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 341.0
SHD2_k127_7025050_5 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000001064 229.0
SHD2_k127_7025050_6 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000001284 229.0
SHD2_k127_7025050_7 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000004352 202.0
SHD2_k127_7025050_8 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000004554 194.0
SHD2_k127_7025050_9 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000000000000000004669 184.0
SHD2_k127_703613_0 Amino acid permease K03294 - - 1.071e-227 713.0
SHD2_k127_703613_1 Oxidoreductase FAD-binding domain protein K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 536.0
SHD2_k127_703613_2 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007286 529.0
SHD2_k127_703613_3 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 508.0
SHD2_k127_703613_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 489.0
SHD2_k127_703613_5 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000811 282.0
SHD2_k127_703613_6 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000001994 249.0
SHD2_k127_703613_7 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000115 137.0
SHD2_k127_7060138_0 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006848 271.0
SHD2_k127_7060138_1 Sh3 type 3 domain protein - - - 0.0000000000000000000000000000000001977 141.0
SHD2_k127_7060409_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365,K05366 - 2.4.1.129,3.4.16.4 0.0 1304.0
SHD2_k127_7060409_1 COG2199 FOG GGDEF domain - - - 0.000000000000000000000000000000000000000005841 168.0
SHD2_k127_7060409_2 - - - - 0.000000000000000000000000000000000005563 139.0
SHD2_k127_7060409_3 OmpA-like transmembrane domain - - - 0.000002715 56.0
SHD2_k127_709010_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 1.215e-295 909.0
SHD2_k127_709010_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 433.0
SHD2_k127_709010_2 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 349.0
SHD2_k127_709010_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 315.0
SHD2_k127_709010_4 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 302.0
SHD2_k127_709010_5 Competence protein K02237 - - 0.000000000000000000000000000000004574 133.0
SHD2_k127_709010_6 Cyd operon protein YbgE (Cyd_oper_YbgE) - - - 0.00000000000000000000000000001915 118.0
SHD2_k127_709010_7 - - - - 0.00000000000000000000001367 100.0
SHD2_k127_709010_8 Peptidase family M48 - - - 0.0000004722 51.0
SHD2_k127_7106290_0 PFAM metallophosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 413.0
SHD2_k127_7106290_1 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000006364 190.0
SHD2_k127_7106290_2 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000004988 144.0
SHD2_k127_7173030_0 Glycosyl transferase family 2 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 470.0
SHD2_k127_7173030_1 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 458.0
SHD2_k127_7173030_2 exodeoxyribonuclease iii K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000001096 233.0
SHD2_k127_7173030_3 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000001429 201.0
SHD2_k127_7224690_0 PFAM Phosphoribosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 320.0
SHD2_k127_7224690_1 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005504 276.0
SHD2_k127_7224690_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001727 259.0
SHD2_k127_722952_0 aminoacyl-histidine dipeptidase K01270 - - 3.644e-235 737.0
SHD2_k127_722952_1 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000003974 204.0
SHD2_k127_722952_2 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000006237 72.0
SHD2_k127_7236817_0 Ammonium Transporter Family K03320 - - 9.961e-251 785.0
SHD2_k127_7236817_1 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000000000000000000003091 218.0
SHD2_k127_725424_0 Protein of unknown function, DUF255 K06888 - - 3.868e-197 623.0
SHD2_k127_725424_1 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 504.0
SHD2_k127_725424_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 335.0
SHD2_k127_725424_3 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000001014 256.0
SHD2_k127_725424_4 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.000001301 51.0
SHD2_k127_7400656_0 cellulose synthase K20541 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 564.0
SHD2_k127_7400656_1 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 0.000000000000000000000000000000004759 139.0
SHD2_k127_7452680_0 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 501.0
SHD2_k127_7452680_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 478.0
SHD2_k127_7452680_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 459.0
SHD2_k127_7452680_3 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 371.0
SHD2_k127_7452680_4 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 330.0
SHD2_k127_7452680_5 Phospholipase/Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000002521 190.0
SHD2_k127_7458126_0 Belongs to the GPI family K01810 GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009209 600.0
SHD2_k127_7458126_1 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 558.0
SHD2_k127_7458126_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 528.0
SHD2_k127_7516090_0 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0 1133.0
SHD2_k127_7516090_1 4 iron, 4 sulfur cluster binding - - - 3.4e-232 730.0
SHD2_k127_7516090_2 CoA-substrate-specific enzyme activase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 569.0
SHD2_k127_7516090_3 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000008198 240.0
SHD2_k127_7516090_4 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000001644 213.0
SHD2_k127_7516090_6 Protein of unknown function (DUF1109) - - - 0.00000000000000000004756 89.0
SHD2_k127_7551188_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 6.872e-279 868.0
SHD2_k127_7551188_1 Mur ligase family, catalytic domain K01924 - 6.3.2.8 2.279e-244 761.0
SHD2_k127_7551188_10 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 387.0
SHD2_k127_7551188_11 MraZ protein, putative antitoxin-like K03925 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 290.0
SHD2_k127_7551188_12 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001766 259.0
SHD2_k127_7551188_13 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000000000000000000000007914 186.0
SHD2_k127_7551188_14 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000000000000000000005823 118.0
SHD2_k127_7551188_15 - - - - 0.0000000002202 66.0
SHD2_k127_7551188_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 2.164e-216 682.0
SHD2_k127_7551188_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 1.141e-201 636.0
SHD2_k127_7551188_4 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 2.018e-200 634.0
SHD2_k127_7551188_5 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 576.0
SHD2_k127_7551188_6 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 564.0
SHD2_k127_7551188_7 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 467.0
SHD2_k127_7551188_8 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 460.0
SHD2_k127_7551188_9 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 450.0
SHD2_k127_75577_0 Histidine kinase - - - 2.97e-225 726.0
SHD2_k127_75577_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 392.0
SHD2_k127_75577_2 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008835 276.0
SHD2_k127_75577_3 glycosyl - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004484 256.0
SHD2_k127_75577_4 COG3038 Cytochrome B561 K12262 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001297 246.0
SHD2_k127_75577_5 glycosyl - - - 0.000000000000000000000000000000000000000000000000008854 185.0
SHD2_k127_75577_6 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000000000000005245 109.0
SHD2_k127_75577_7 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.0000000002421 60.0
SHD2_k127_7591108_0 PAS domain containing protein K07315,K07675 - 2.7.13.3,3.1.3.3 0.0 1139.0
SHD2_k127_7591108_1 crp fnr family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007369 349.0
SHD2_k127_7591108_2 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 339.0
SHD2_k127_7591108_3 Hsp90 protein K04079 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 338.0
SHD2_k127_7591108_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 315.0
SHD2_k127_7591108_5 - - - - 0.0000000000003197 72.0
SHD2_k127_7591108_6 - - - - 0.0000000000006346 75.0
SHD2_k127_7591108_7 Methyltransferase domain - - - 0.00000000318 58.0
SHD2_k127_7593763_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 2.433e-203 639.0
SHD2_k127_7593763_1 PFAM AIR synthase related protein domain protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 592.0
SHD2_k127_7593763_10 aspartyl protease K06985 - - 0.000000000451 67.0
SHD2_k127_7593763_11 tetratricopeptide repeat - - - 0.0006703 51.0
SHD2_k127_7593763_2 TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 362.0
SHD2_k127_7593763_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 362.0
SHD2_k127_7593763_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 302.0
SHD2_k127_7593763_5 Bacterial dnaA protein K10763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003924 295.0
SHD2_k127_7593763_6 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003102 248.0
SHD2_k127_7593763_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001022 237.0
SHD2_k127_7593763_8 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000000000000000001005 220.0
SHD2_k127_7593763_9 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000001653 211.0
SHD2_k127_7601287_0 Belongs to the peptidase M16 family K07263 - - 1.368e-210 662.0
SHD2_k127_7601287_1 Peptidase M16 inactive domain K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 569.0
SHD2_k127_7601287_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 507.0
SHD2_k127_7601287_3 TIGRFAM cell division ATP-binding protein FtsE K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 368.0
SHD2_k127_7601287_4 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 349.0
SHD2_k127_7601287_5 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003479 270.0
SHD2_k127_7601287_6 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002129 268.0
SHD2_k127_7601287_7 Hemolysin III K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000001987 230.0
SHD2_k127_7601287_8 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000001609 164.0
SHD2_k127_7602697_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.0 1028.0
SHD2_k127_7602697_1 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 425.0
SHD2_k127_7602697_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 317.0
SHD2_k127_7643227_0 PFAM TonB-dependent receptor plug K02014,K16089 - - 2.841e-287 898.0
SHD2_k127_7643227_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 555.0
SHD2_k127_7643227_2 Signal transduction response regulator, receiver region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 406.0
SHD2_k127_7643227_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000008842 196.0
SHD2_k127_7643227_4 Domain of unknown function (DUF4154) - - - 0.0000000000000000000000000000000000000006072 154.0
SHD2_k127_7643227_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000002548 66.0
SHD2_k127_7650141_0 ABC transporter transmembrane region K06147 - - 5.628e-306 947.0
SHD2_k127_7650141_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 4.944e-255 791.0
SHD2_k127_7650141_10 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 315.0
SHD2_k127_7650141_11 molybdenum cofactor K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 287.0
SHD2_k127_7650141_12 Lysin motif K06194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000414 284.0
SHD2_k127_7650141_13 Cytochrome b/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004422 254.0
SHD2_k127_7650141_14 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000006258 167.0
SHD2_k127_7650141_15 - - - - 0.000000000000000000000000000000000000000000131 164.0
SHD2_k127_7650141_16 - - - - 0.000000000000001316 78.0
SHD2_k127_7650141_18 Domain of unknown function (DUF4468) with TBP-like fold - - - 0.000000001244 70.0
SHD2_k127_7650141_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 518.0
SHD2_k127_7650141_3 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 446.0
SHD2_k127_7650141_4 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 436.0
SHD2_k127_7650141_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 413.0
SHD2_k127_7650141_6 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 402.0
SHD2_k127_7650141_7 PFAM peptidase S11 D-alanyl-D-alanine carboxypeptidase 1 K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 351.0
SHD2_k127_7650141_8 mechanosensitive - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 334.0
SHD2_k127_7650141_9 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 318.0
SHD2_k127_7650518_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.056e-251 779.0
SHD2_k127_7650518_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 539.0
SHD2_k127_7650518_10 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000000000000418 230.0
SHD2_k127_7650518_11 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000000000001394 210.0
SHD2_k127_7650518_12 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000009198 190.0
SHD2_k127_7650518_13 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000000000002399 162.0
SHD2_k127_7650518_14 - - - - 0.000000000000000000000000000000000000000005879 157.0
SHD2_k127_7650518_15 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000000222 141.0
SHD2_k127_7650518_16 - - - - 0.0000000000000000000000000000005715 126.0
SHD2_k127_7650518_17 Ribosomal protein L30p/L7e K02907 - - 0.0000000000000000000000000003104 113.0
SHD2_k127_7650518_18 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000006426 74.0
SHD2_k127_7650518_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008485 374.0
SHD2_k127_7650518_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 312.0
SHD2_k127_7650518_4 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 310.0
SHD2_k127_7650518_5 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 284.0
SHD2_k127_7650518_6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007447 255.0
SHD2_k127_7650518_7 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A K02876 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008671 246.0
SHD2_k127_7650518_8 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004256 244.0
SHD2_k127_7650518_9 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002174 239.0
SHD2_k127_7687899_0 Tetratricopeptide repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 582.0
SHD2_k127_7687899_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 377.0
SHD2_k127_7687899_2 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 360.0
SHD2_k127_7687899_3 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002214 285.0
SHD2_k127_7687899_4 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.000000000000000000000000000000000000000000000000000004117 195.0
SHD2_k127_7744856_0 surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 405.0
SHD2_k127_7744856_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000002305 103.0
SHD2_k127_7757441_0 Alternative locus ID - - - 0.00000000000138 74.0
SHD2_k127_7757441_1 iron-sulfur cluster-binding protein K18929 - - 0.0002371 53.0
SHD2_k127_7759688_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 4.223e-257 798.0
SHD2_k127_7759688_1 PFAM type II and III secretion system protein K02666 - - 3.163e-246 777.0
SHD2_k127_7759688_2 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 604.0
SHD2_k127_7759688_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 570.0
SHD2_k127_7759688_4 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 393.0
SHD2_k127_7759688_5 LytTr DNA-binding domain K08083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 299.0
SHD2_k127_7759688_6 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000001626 246.0
SHD2_k127_7759688_7 Pilus assembly protein, PilP K02665 - - 0.0000000000000000000000000000000000000000000000000000000000000007269 222.0
SHD2_k127_7759688_8 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000006198 171.0
SHD2_k127_77683_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 463.0
SHD2_k127_77683_1 Rhodanese Homology Domain K06917 - - 0.000000000000000000000000000000000000000000000000000001309 196.0
SHD2_k127_77683_2 metal-dependent phosphohydrolase HD sub domain - - - 0.00000000000000000000000000000000000000000000000009345 178.0
SHD2_k127_7775197_0 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009703 527.0
SHD2_k127_7775197_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000003113 237.0
SHD2_k127_7775197_2 Zinc-finger domain - - - 0.00000000000000000000004013 99.0
SHD2_k127_7775197_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000001786 87.0
SHD2_k127_7784442_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 6.008e-318 977.0
SHD2_k127_7784442_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 340.0
SHD2_k127_7784442_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000001205 249.0
SHD2_k127_7784442_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000003891 156.0
SHD2_k127_7784442_4 ATP synthase I chain K02116 - - 0.00000003487 59.0
SHD2_k127_7839130_0 AAA domain K02224 - 6.3.5.11,6.3.5.9 6.131e-227 711.0
SHD2_k127_7839130_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 3.346e-213 668.0
SHD2_k127_7839130_2 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008629 581.0
SHD2_k127_7839130_3 Glycosyl transferase - GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 376.0
SHD2_k127_7839130_4 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000002168 243.0
SHD2_k127_7839130_5 TIGRFAM sulfur relay protein, TusE DsrC DsvC family K11179 - - 0.00002868 47.0
SHD2_k127_7877680_0 PFAM Bile acid sodium symporter K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 560.0
SHD2_k127_7877680_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 458.0
SHD2_k127_7877680_2 SMART Protein-tyrosine phosphatase, low molecular weight K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 304.0
SHD2_k127_7877680_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000000000002425 166.0
SHD2_k127_7877680_4 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000004743 126.0
SHD2_k127_7877680_5 elongation factor Tu K02358 - - 0.0000000000000000005432 86.0
SHD2_k127_7881557_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005828 595.0
SHD2_k127_7881557_1 DNA polymerase alpha chain like domain K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 439.0
SHD2_k127_7881557_2 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 389.0
SHD2_k127_7881557_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008345 287.0
SHD2_k127_7881557_4 TIGRFAM Sua5 YciO YrdC YwlC family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000219 284.0
SHD2_k127_7881557_5 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000514 248.0
SHD2_k127_7881557_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000002419 222.0
SHD2_k127_7881557_7 Copper resistance protein D - - - 0.0000000000000000000000000000000000000000000000000000004874 198.0
SHD2_k127_7881557_8 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000001473 156.0
SHD2_k127_7881557_9 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000000000000000000000000000000000006963 156.0
SHD2_k127_7912610_0 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 5.163e-214 706.0
SHD2_k127_7912610_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 578.0
SHD2_k127_7912610_10 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000003484 114.0
SHD2_k127_7912610_2 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 552.0
SHD2_k127_7912610_3 Transglycosylase SLT domain K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 397.0
SHD2_k127_7912610_4 SIR2-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 327.0
SHD2_k127_7912610_5 DegT/DnrJ/EryC1/StrS aminotransferase family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000001079 224.0
SHD2_k127_7912610_6 Smr domain - - - 0.00000000000000000000000000000000000000000000000000000000001474 213.0
SHD2_k127_7912610_7 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000002068 200.0
SHD2_k127_7912610_8 NlpC/P60 family K19303 - - 0.0000000000000000000000000000000000000000000001991 171.0
SHD2_k127_7912610_9 Ferredoxin K04755 - - 0.0000000000000000000000000000000000000001114 152.0
SHD2_k127_7919484_0 MltA specific insert domain K08304 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 545.0
SHD2_k127_7919484_1 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 451.0
SHD2_k127_7919484_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 435.0
SHD2_k127_7919484_3 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 405.0
SHD2_k127_7919484_4 Phosphoesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 399.0
SHD2_k127_7919484_5 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001771 266.0
SHD2_k127_7919484_6 ApaG domain K06195 - - 0.0000000000000000000000000000000000000000000000000000003685 196.0
SHD2_k127_7919484_7 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0000000000000000000000000000000000000005315 149.0
SHD2_k127_7922486_0 TIGRFAM DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 548.0
SHD2_k127_7922486_1 metal-dependent phosphohydrolase, HD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 377.0
SHD2_k127_7922486_2 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 323.0
SHD2_k127_7922486_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000002552 244.0
SHD2_k127_7922486_4 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000000000000000000009104 226.0
SHD2_k127_7924089_0 endonuclease III K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 541.0
SHD2_k127_7924089_1 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000952 494.0
SHD2_k127_7924089_2 PFAM membrane bound O-acyl transferase MBOAT family protein K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009289 315.0
SHD2_k127_7924089_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000000000004542 159.0
SHD2_k127_7924089_4 membrane - - - 0.00000000000000000000000000000000000000000206 158.0
SHD2_k127_7924089_5 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000000000000008878 140.0
SHD2_k127_7924089_6 AsmA family K07289 - - 0.00000001946 57.0
SHD2_k127_7946341_0 Ammonium Transporter Family K03320 - - 8.152e-229 711.0
SHD2_k127_7946341_1 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003485 269.0
SHD2_k127_7946341_2 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003184 258.0
SHD2_k127_7946341_3 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000000000000000000000000006816 203.0
SHD2_k127_7946341_4 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000000000000000000000000000000000000000000009103 163.0
SHD2_k127_7946341_5 Membrane fusogenic activity K09806 - - 0.0000000000000000000000003454 106.0
SHD2_k127_7946341_6 Ammonium Transporter Family K03320 - - 0.0000000000000000003835 89.0
SHD2_k127_7981401_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1259.0
SHD2_k127_7981401_1 Oxidoreductase FAD-binding domain K14581 - 1.18.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 426.0
SHD2_k127_7981401_2 VanZ like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 399.0
SHD2_k127_7981401_3 Serine aminopeptidase, S33 K07018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 323.0
SHD2_k127_7981401_4 Hemerythrin HHE cation binding domain protein K07216 - - 0.0000000000000000000000000000000000000000000000000000000000000001186 226.0
SHD2_k127_7981401_5 COG2346, Truncated hemoglobins K03406,K06886 GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016491,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0020012,GO:0020037,GO:0030682,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042737,GO:0043207,GO:0044237,GO:0044248,GO:0044270,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0048037,GO:0050896,GO:0051213,GO:0051410,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0065007,GO:0065008,GO:0072593,GO:0075136,GO:0097159,GO:0098754,GO:1901363,GO:1901698,GO:2001057 - 0.0000000000000000000000000000000000000000000000000000000000000005796 222.0
SHD2_k127_7981401_6 Ferredoxin - - - 0.0000000000000000000000000000000000000000000000005139 177.0
SHD2_k127_7981401_7 TIGRFAM transcriptional regulator, Rrf2 family K13771 - - 0.00000000000000000000000000000000000000000000003859 176.0
SHD2_k127_8109085_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 2.5e-322 989.0
SHD2_k127_8109085_1 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 5.914e-246 764.0
SHD2_k127_8109085_10 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000000000000000001405 212.0
SHD2_k127_8109085_11 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000000000000000000000000395 211.0
SHD2_k127_8109085_12 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169,K03737 - 1.2.7.1 0.000000000000000000000000000000000000000000001096 166.0
SHD2_k127_8109085_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 3.425e-235 734.0
SHD2_k127_8109085_3 PFAM Thiamine pyrophosphate K00170,K18356 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 596.0
SHD2_k127_8109085_4 Transporter associated domain K06189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 460.0
SHD2_k127_8109085_5 PFAM PhoH family protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 460.0
SHD2_k127_8109085_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 381.0
SHD2_k127_8109085_7 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 286.0
SHD2_k127_8109085_8 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003164 242.0
SHD2_k127_8109085_9 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000001615 229.0
SHD2_k127_8141991_0 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 3.55e-244 756.0
SHD2_k127_8141991_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 422.0
SHD2_k127_8141991_2 Segregation and condensation complex subunit ScpB K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000076 243.0
SHD2_k127_8141991_3 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000002143 226.0
SHD2_k127_8147125_0 PFAM FAD linked oxidase domain protein K00102 - 1.1.2.4 1.505e-229 718.0
SHD2_k127_8147125_1 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 529.0
SHD2_k127_8147125_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 418.0
SHD2_k127_8147125_3 Planctomycete cytochrome C - - - 0.0000000000000000000000000000000000000000000000002087 178.0
SHD2_k127_8147125_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000001244 111.0
SHD2_k127_8147125_5 - - - - 0.000000000000000000003681 98.0
SHD2_k127_8147125_7 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000744 70.0
SHD2_k127_8180605_0 sensor diguanylate cyclase phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 493.0
SHD2_k127_8180605_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 396.0
SHD2_k127_8180605_2 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000000000000000000000478 214.0
SHD2_k127_8180605_3 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000003655 108.0
SHD2_k127_81875_0 MgtE intracellular N domain K06213 - - 4.377e-252 786.0
SHD2_k127_81875_1 Elongator protein 3, MiaB family, Radical SAM - - - 9.98e-248 771.0
SHD2_k127_81875_2 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000004791 181.0
SHD2_k127_81875_3 cytochrome b561 K12262 - - 0.000000000000000000000000000009202 124.0
SHD2_k127_81875_4 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000001215 83.0
SHD2_k127_8197197_0 type III restriction protein res subunit K01153 - 3.1.21.3 0.0 1162.0
SHD2_k127_8197197_1 N-6 DNA methylase K03427 - 2.1.1.72 9.83e-293 904.0
SHD2_k127_8197197_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000147 273.0
SHD2_k127_8197197_11 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000002501 237.0
SHD2_k127_8197197_12 TIGRFAM Nucleotidyltransferase substrate binding protein, HI0074 - - - 0.000000000000000000000000000000000000000000000000000000001566 202.0
SHD2_k127_8197197_13 Carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000001856 183.0
SHD2_k127_8197197_14 PFAM Nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000003238 162.0
SHD2_k127_8197197_15 PFAM Plasmid stabilisation system K06218 - - 0.00000000000000000000000000000004628 127.0
SHD2_k127_8197197_16 Domain of unknown function (DUF4389) - - - 0.000000000000000000000002182 105.0
SHD2_k127_8197197_17 Type I restriction modification DNA specificity domain - - - 0.00000000000000000004142 93.0
SHD2_k127_8197197_18 Antitoxin component of a toxin-antitoxin (TA) module K18923 - - 0.00000000000008987 74.0
SHD2_k127_8197197_19 Protein of unknown function (DUF3460) - - - 0.000000004935 59.0
SHD2_k127_8197197_2 PFAM CHAD domain containing protein - - - 1.234e-209 662.0
SHD2_k127_8197197_3 protein conserved in bacteria K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 583.0
SHD2_k127_8197197_4 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 470.0
SHD2_k127_8197197_5 Dienelactone hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 400.0
SHD2_k127_8197197_6 Thiopurine S-methyltransferase (TPMT) K00569 - 2.1.1.67 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 334.0
SHD2_k127_8197197_7 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000606 314.0
SHD2_k127_8197197_8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 289.0
SHD2_k127_8197197_9 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007997 282.0
SHD2_k127_8267991_0 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 7.36e-201 625.0
SHD2_k127_8267991_1 (GGDEF) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008169 516.0
SHD2_k127_8267991_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 359.0
SHD2_k127_8267991_3 PFAM Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 332.0
SHD2_k127_8267991_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000001881 258.0
SHD2_k127_8267991_5 PFAM Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain K01945 - 6.3.4.13 0.000000000000000000000000000006475 128.0
SHD2_k127_8305385_0 TIGRFAM fructose-bisphosphate aldolase, class II, Calvin cycle subtype K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 586.0
SHD2_k127_8305385_1 Belongs to the RuBisCO large chain family K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007272 510.0
SHD2_k127_8305385_2 PFAM type II secretion system protein E K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009636 512.0
SHD2_k127_8305385_3 LysR substrate binding domain K21703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 456.0
SHD2_k127_833131_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 588.0
SHD2_k127_833131_1 PFAM Haloacid dehalogenase domain protein hydrolase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 437.0
SHD2_k127_833131_2 TIGRFAM ATP-dependent Clp protease, ATP-binding subunit clpA K03694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000305 250.0
SHD2_k127_833131_3 - - - - 0.0000000000000000000000000000000000000000000000000001115 192.0
SHD2_k127_8357846_0 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 592.0
SHD2_k127_8357846_1 TIGRFAM DNA polymerase III, delta prime subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 423.0
SHD2_k127_8357846_2 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 397.0
SHD2_k127_8357846_3 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 346.0
SHD2_k127_8357846_4 PFAM AMMECR1 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005523 247.0
SHD2_k127_8357846_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000002829 130.0
SHD2_k127_8358713_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 3.251e-267 829.0
SHD2_k127_8358713_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000000000000000003181 144.0
SHD2_k127_8381225_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 8.413e-280 861.0
SHD2_k127_8381225_1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 285.0
SHD2_k127_8405575_0 histidine kinase HAMP region domain protein - - - 1.478e-280 878.0
SHD2_k127_8405575_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 597.0
SHD2_k127_8405575_10 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 286.0
SHD2_k127_8405575_11 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 287.0
SHD2_k127_8405575_12 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000006617 251.0
SHD2_k127_8405575_13 Protein of unknown function (DUF494) K03747 - - 0.00000000000000000000000000000000000000000000000000000003262 199.0
SHD2_k127_8405575_14 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000000000006863 190.0
SHD2_k127_8405575_15 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.00000000000000000000000000000000006192 133.0
SHD2_k127_8405575_16 Domain of unknown function (DUF4124) - - - 0.0000000000000000000000000003405 123.0
SHD2_k127_8405575_17 - - - - 0.0000008636 54.0
SHD2_k127_8405575_2 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 553.0
SHD2_k127_8405575_3 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 489.0
SHD2_k127_8405575_4 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 443.0
SHD2_k127_8405575_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 429.0
SHD2_k127_8405575_6 LysM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 402.0
SHD2_k127_8405575_7 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 370.0
SHD2_k127_8405575_8 Carbonic anhydrase K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 320.0
SHD2_k127_8405575_9 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 312.0
SHD2_k127_892989_0 acyl-CoA dehydrogenase K06445 - - 4.195e-236 745.0
SHD2_k127_938266_0 Likely ribonuclease with RNase H fold. K06959 - - 0.0 1255.0
SHD2_k127_938266_1 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000005384 177.0
SHD2_k127_950405_0 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 416.0
SHD2_k127_950405_1 fad dependent oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 340.0
SHD2_k127_950405_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 295.0
SHD2_k127_950405_3 PFAM Dihaem cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 283.0
SHD2_k127_950405_4 - - - - 0.000000000000000000000000000000000000000000000000000000007679 205.0
SHD2_k127_950405_5 Domain of unknown function (DUF1924) - - - 0.000000000000000000000000000000000000000000000000009031 184.0
SHD2_k127_950405_6 Cytochrome b/b6/petB - - - 0.00000000000000000000000000000000001683 137.0