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Overview

ID MAG03371
Name SHD2_bin.11
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Terriglobia
Order Terriglobales
Family Korobacteraceae
Genus DASPLH01
Species
Assembly information
Completeness (%) 84.04
Contamination (%) 2.94
GC content (%) 57.0
N50 (bp) 45,861
Genome size (bp) 3,241,290

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2755

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1056849_0 Radical SAM - - - 0.0 1289.0
SHD2_k127_1056849_1 cell shape determining protein MreB K03569 - - 1.088e-213 665.0
SHD2_k127_1056849_10 PspC domain K03973 - - 0.0000000000000000000000551 102.0
SHD2_k127_1056849_11 Domain of unknown function (DUF4139) - - - 0.00000000006405 64.0
SHD2_k127_1056849_12 ketosteroid isomerase - - - 0.0006794 49.0
SHD2_k127_1056849_2 PFAM FecR protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 439.0
SHD2_k127_1056849_3 Rod shape-determining protein MreC K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 342.0
SHD2_k127_1056849_4 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001877 225.0
SHD2_k127_1056849_5 shape-determining protein MreD K03571 - - 0.0000000000000000000000000000000000000000000000000000000001212 208.0
SHD2_k127_1056849_6 Aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 0.0000000000000000000000000000000000000000001092 161.0
SHD2_k127_1056849_7 Cupin domain - - - 0.00000000000000000000000000000000004303 141.0
SHD2_k127_1056849_8 Cold shock protein K03704 - - 0.0000000000000000000000000000000006399 131.0
SHD2_k127_1056849_9 Glucose dehydrogenase C-terminus - - - 0.00000000000000000000000004085 110.0
SHD2_k127_1108483_0 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 529.0
SHD2_k127_1108483_1 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 305.0
SHD2_k127_1165032_0 Vitamin B12 dependent methionine synthase activation K00548 - 2.1.1.13 0.0 1685.0
SHD2_k127_1165032_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1247.0
SHD2_k127_1165032_10 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 1.598e-263 827.0
SHD2_k127_1165032_100 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000001037 187.0
SHD2_k127_1165032_101 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000003229 186.0
SHD2_k127_1165032_102 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000006302 183.0
SHD2_k127_1165032_103 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000001021 174.0
SHD2_k127_1165032_104 BON domain - - - 0.0000000000000000000000000000000000000000000002504 181.0
SHD2_k127_1165032_105 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000000004644 162.0
SHD2_k127_1165032_106 Gas vesicle protein K - - - 0.0000000000000000000000000000000000000000002181 161.0
SHD2_k127_1165032_107 Response regulator, receiver K10819,K20975 - 2.7.13.3 0.0000000000000000000000000000000000000000004102 160.0
SHD2_k127_1165032_108 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000000000000005047 158.0
SHD2_k127_1165032_109 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K00340 - 1.6.5.3 0.0000000000000000000000000000000000000000009175 159.0
SHD2_k127_1165032_11 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 3.318e-261 813.0
SHD2_k127_1165032_110 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000002644 159.0
SHD2_k127_1165032_111 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000003394 156.0
SHD2_k127_1165032_112 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000000006506 158.0
SHD2_k127_1165032_113 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000006781 158.0
SHD2_k127_1165032_114 Type IV pilus biogenesis stability protein PilW - - - 0.00000000000000000000000000000000000004226 150.0
SHD2_k127_1165032_116 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.000000000000000000000000000000000002326 139.0
SHD2_k127_1165032_117 HAD superfamily, subfamily IIIB (Acid phosphatase) - - - 0.0000000000000000000000000000000001018 137.0
SHD2_k127_1165032_118 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.0000000000000000000000000000000001368 135.0
SHD2_k127_1165032_119 - - - - 0.000000000000000000000000000000002642 138.0
SHD2_k127_1165032_12 Proton-conducting membrane transporter K00342 - 1.6.5.3 2.545e-255 797.0
SHD2_k127_1165032_120 Frataxin-like domain K06202 - - 0.000000000000000000000000000000164 126.0
SHD2_k127_1165032_121 Peptidase M48 K06013 - 3.4.24.84 0.00000000000000000000000003071 122.0
SHD2_k127_1165032_123 Protein of unknown function (DUF1569) - - - 0.000000000000000000000004221 108.0
SHD2_k127_1165032_124 peptidyl-prolyl cis-trans isomerase activity K03771 - 5.2.1.8 0.0000000000000000000001705 111.0
SHD2_k127_1165032_126 mttA/Hcf106 family K03117 - - 0.000000000000000005059 90.0
SHD2_k127_1165032_127 Glycosyl transferase, family 2 - - - 0.00000000000000001285 88.0
SHD2_k127_1165032_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.317e-253 791.0
SHD2_k127_1165032_130 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000171 82.0
SHD2_k127_1165032_133 Glutaredoxin - - - 0.000000000000003281 76.0
SHD2_k127_1165032_134 thiamine biosynthesis protein ThiS K03154 - - 0.000000000000004493 79.0
SHD2_k127_1165032_136 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.0000000001598 64.0
SHD2_k127_1165032_14 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 2.901e-242 756.0
SHD2_k127_1165032_15 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 6.407e-236 742.0
SHD2_k127_1165032_16 HD domain - - - 1.266e-235 743.0
SHD2_k127_1165032_17 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 4.544e-225 713.0
SHD2_k127_1165032_18 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.808e-224 708.0
SHD2_k127_1165032_19 Pyridoxal-dependent decarboxylase conserved domain - - - 5.62e-212 670.0
SHD2_k127_1165032_2 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 0.0 1184.0
SHD2_k127_1165032_20 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 5.331e-210 659.0
SHD2_k127_1165032_21 Mur ligase middle domain K02558 - 6.3.2.45 1.649e-204 646.0
SHD2_k127_1165032_22 Glycosyl hydrolases family 15 - - - 7.611e-204 651.0
SHD2_k127_1165032_23 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 5.767e-199 626.0
SHD2_k127_1165032_24 Proton-conducting membrane transporter K00343 - 1.6.5.3 2.146e-197 628.0
SHD2_k127_1165032_25 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 1.811e-195 615.0
SHD2_k127_1165032_26 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 623.0
SHD2_k127_1165032_27 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 617.0
SHD2_k127_1165032_28 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 600.0
SHD2_k127_1165032_29 NADH dehydrogenase K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 588.0
SHD2_k127_1165032_3 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1162.0
SHD2_k127_1165032_30 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 587.0
SHD2_k127_1165032_31 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 548.0
SHD2_k127_1165032_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 522.0
SHD2_k127_1165032_33 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 521.0
SHD2_k127_1165032_34 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 514.0
SHD2_k127_1165032_35 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000313 503.0
SHD2_k127_1165032_36 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 494.0
SHD2_k127_1165032_37 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005018 487.0
SHD2_k127_1165032_38 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 479.0
SHD2_k127_1165032_39 alcohol dehydrogenase K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005788 463.0
SHD2_k127_1165032_4 CHASE3 domain - - - 3.822e-317 983.0
SHD2_k127_1165032_40 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 446.0
SHD2_k127_1165032_41 TIGRFAM aspartate ammonia-lyase K01679,K01744 - 4.2.1.2,4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 456.0
SHD2_k127_1165032_42 amidase activity K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 446.0
SHD2_k127_1165032_43 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 443.0
SHD2_k127_1165032_44 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 438.0
SHD2_k127_1165032_45 TrkA-C domain K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 439.0
SHD2_k127_1165032_46 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 413.0
SHD2_k127_1165032_47 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 413.0
SHD2_k127_1165032_48 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 396.0
SHD2_k127_1165032_49 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 402.0
SHD2_k127_1165032_5 Sodium:solute symporter family - - - 2.096e-314 970.0
SHD2_k127_1165032_50 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 392.0
SHD2_k127_1165032_51 pfam abc K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 384.0
SHD2_k127_1165032_52 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009176 387.0
SHD2_k127_1165032_53 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 375.0
SHD2_k127_1165032_54 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 398.0
SHD2_k127_1165032_55 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 366.0
SHD2_k127_1165032_56 RsbT co-antagonist protein rsbRD N-terminal domain K17763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 352.0
SHD2_k127_1165032_57 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 348.0
SHD2_k127_1165032_58 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 344.0
SHD2_k127_1165032_59 PFAM Integral membrane protein TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 338.0
SHD2_k127_1165032_6 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 9.481e-308 958.0
SHD2_k127_1165032_60 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 333.0
SHD2_k127_1165032_61 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 321.0
SHD2_k127_1165032_62 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 316.0
SHD2_k127_1165032_63 Stage II sporulation protein E - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 319.0
SHD2_k127_1165032_64 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 305.0
SHD2_k127_1165032_65 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 309.0
SHD2_k127_1165032_66 spore germination - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 309.0
SHD2_k127_1165032_67 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 317.0
SHD2_k127_1165032_68 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 305.0
SHD2_k127_1165032_69 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 302.0
SHD2_k127_1165032_7 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.489e-296 913.0
SHD2_k127_1165032_70 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 299.0
SHD2_k127_1165032_71 ABC-type sugar transport system periplasmic component K02058,K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 291.0
SHD2_k127_1165032_72 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 287.0
SHD2_k127_1165032_73 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008073 281.0
SHD2_k127_1165032_74 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000002668 263.0
SHD2_k127_1165032_75 Bacterial Peptidase A24 N-terminal domain K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000001461 265.0
SHD2_k127_1165032_76 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005828 252.0
SHD2_k127_1165032_77 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000006502 249.0
SHD2_k127_1165032_78 RmlD substrate binding domain K15856 - 1.1.1.281 0.000000000000000000000000000000000000000000000000000000000000000000000008736 253.0
SHD2_k127_1165032_79 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000002509 238.0
SHD2_k127_1165032_8 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.805e-283 881.0
SHD2_k127_1165032_80 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.00000000000000000000000000000000000000000000000000000000000000000005044 237.0
SHD2_k127_1165032_81 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000007283 237.0
SHD2_k127_1165032_82 MgtC family K07507 - - 0.000000000000000000000000000000000000000000000000000000000000000004474 232.0
SHD2_k127_1165032_83 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000007583 229.0
SHD2_k127_1165032_84 Histidine kinase-like ATPase domain K01338,K04757,K06379,K08282,K17752 - 2.7.11.1,3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000002368 221.0
SHD2_k127_1165032_85 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000000000000006468 215.0
SHD2_k127_1165032_86 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000001744 223.0
SHD2_k127_1165032_87 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000007623 212.0
SHD2_k127_1165032_89 - - - - 0.00000000000000000000000000000000000000000000000000000001608 205.0
SHD2_k127_1165032_9 Belongs to the UbiD family K03182 - 4.1.1.98 1.651e-269 839.0
SHD2_k127_1165032_90 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000009237 200.0
SHD2_k127_1165032_91 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000000000005305 194.0
SHD2_k127_1165032_92 plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000007174 194.0
SHD2_k127_1165032_93 FecR protein - - - 0.00000000000000000000000000000000000000000000000000005097 211.0
SHD2_k127_1165032_94 - - - - 0.00000000000000000000000000000000000000000000000000008373 195.0
SHD2_k127_1165032_95 PFAM Sulphate transporter antisigma-factor antagonist STAS K17762 - - 0.000000000000000000000000000000000000000000000000001409 185.0
SHD2_k127_1165032_96 Protein of unknown function (DUF3592) - - - 0.000000000000000000000000000000000000000000000000002935 207.0
SHD2_k127_1165032_97 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000004804 184.0
SHD2_k127_1165032_98 - - - - 0.000000000000000000000000000000000000000000000000007357 185.0
SHD2_k127_1165032_99 Histidine kinase-like ATPase domain K17752 - 2.7.11.1 0.000000000000000000000000000000000000000000000000007533 184.0
SHD2_k127_1175786_0 Participates in both transcription termination and antitermination K02600 - - 7.037e-203 651.0
SHD2_k127_1187185_0 TIGRFAM Malto-oligosyltrehalose synthase K06044 - 5.4.99.15 2.43e-263 832.0
SHD2_k127_1187185_1 PFAM glycoside hydrolase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 417.0
SHD2_k127_1187185_2 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 351.0
SHD2_k127_1187185_3 - - - - 0.0000000000001071 73.0
SHD2_k127_1206104_0 Putative glucoamylase K01183 - 3.2.1.14 2.369e-279 876.0
SHD2_k127_1206104_1 glutamate decarboxylase activity K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 526.0
SHD2_k127_1206104_2 Histidine kinase - - - 0.0000000000000000000000000000000000000002195 157.0
SHD2_k127_1206104_3 cell redox homeostasis - - - 0.00000000000000000000000000008933 122.0
SHD2_k127_1233028_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.78e-312 960.0
SHD2_k127_1233028_1 Amidohydrolase family - - - 2.347e-198 627.0
SHD2_k127_1233028_10 - - - - 0.000000000000000000000000000005003 124.0
SHD2_k127_1233028_11 Domain of unknown function (DUF4347) K20276 - - 0.000000000000000000000000001258 130.0
SHD2_k127_1233028_12 restriction endonuclease - - - 0.0000000000003505 70.0
SHD2_k127_1233028_13 Dehydrogenase E1 component - - - 0.0004508 53.0
SHD2_k127_1233028_2 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 334.0
SHD2_k127_1233028_3 DNA-binding transcription factor activity - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010288,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032791,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097063,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000119 255.0
SHD2_k127_1233028_4 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000848 241.0
SHD2_k127_1233028_5 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002024 226.0
SHD2_k127_1233028_6 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000399 214.0
SHD2_k127_1233028_7 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000001486 166.0
SHD2_k127_1233028_8 - K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000009474 164.0
SHD2_k127_1233028_9 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772,K09568 - 5.2.1.8 0.000000000000000000000000000000000003717 150.0
SHD2_k127_1253478_0 Permease family K06901 - - 9.474e-202 644.0
SHD2_k127_1253478_1 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 491.0
SHD2_k127_1253478_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 336.0
SHD2_k127_1253478_3 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005966 258.0
SHD2_k127_1253478_4 Polysulphide reductase, NrfD - - - 0.00000000000000000000000001139 113.0
SHD2_k127_1253478_5 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000002154 88.0
SHD2_k127_1253478_6 Domain of unknown function (DUF4440) - - - 0.000006472 55.0
SHD2_k127_1282150_0 DEAD DEAH box helicase K03724 - - 0.0 1896.0
SHD2_k127_1282150_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 6.498e-224 697.0
SHD2_k127_1282150_10 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000003802 216.0
SHD2_k127_1282150_11 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000000000000003108 198.0
SHD2_k127_1282150_12 Cold shock protein K03704 - - 0.00000000000000000000000000000002513 126.0
SHD2_k127_1282150_13 - - - - 0.0000000000000000000000000003727 118.0
SHD2_k127_1282150_14 Response regulator, receiver - - - 0.000000000000000000000004865 108.0
SHD2_k127_1282150_15 - - - - 0.000000000000000002048 91.0
SHD2_k127_1282150_2 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 2.738e-201 632.0
SHD2_k127_1282150_3 Asparaginase K01444 - 3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 558.0
SHD2_k127_1282150_4 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 468.0
SHD2_k127_1282150_5 Putative esterase K07214 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 427.0
SHD2_k127_1282150_6 translation release factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 383.0
SHD2_k127_1282150_7 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 305.0
SHD2_k127_1282150_8 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005185 287.0
SHD2_k127_1282150_9 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003818 258.0
SHD2_k127_1291766_0 Ammonium Transporter K03320 - - 3.258e-214 674.0
SHD2_k127_1291766_1 Receptor family ligand binding region - - - 2.347e-210 670.0
SHD2_k127_1291766_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 543.0
SHD2_k127_1291766_3 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 520.0
SHD2_k127_1291766_4 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 289.0
SHD2_k127_1291766_5 oxidation-reduction process K18239,K18240 GO:0003674,GO:0003824,GO:0016787,GO:0016801,GO:0016803 3.3.2.13,4.1.3.40,4.1.3.45 0.000000000000000000000000000000000000000000000000000000000000000000003622 239.0
SHD2_k127_1291766_6 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000001241 186.0
SHD2_k127_1304506_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 0.0 1014.0
SHD2_k127_1304506_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 439.0
SHD2_k127_1304506_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000000000004641 160.0
SHD2_k127_133485_0 Two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 6.431e-231 722.0
SHD2_k127_133485_1 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005626 280.0
SHD2_k127_133485_2 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000008015 188.0
SHD2_k127_133485_3 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.00000000000000000000000000000000000000005486 156.0
SHD2_k127_1336854_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 2.351e-241 762.0
SHD2_k127_1336854_1 synthetase, class II (G H P K01892 - 6.1.1.21 5.773e-205 645.0
SHD2_k127_1336854_2 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008323 256.0
SHD2_k127_1336854_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000005301 211.0
SHD2_k127_1336854_4 Dioxygenase - - - 0.000000000000000000000000000000001476 137.0
SHD2_k127_1347157_0 Sortilin, neurotensin receptor 3, - - - 0.0 1170.0
SHD2_k127_1347157_1 GTP-binding protein TypA K06207 - - 0.0 1002.0
SHD2_k127_1347157_10 - - - - 0.0000000000000000000003764 108.0
SHD2_k127_1347157_2 glutamine synthetase K01915 - 6.3.1.2 4.449e-272 842.0
SHD2_k127_1347157_3 Protein of unknown function (DUF1501) - - - 2.612e-196 618.0
SHD2_k127_1347157_4 Glycosyl hydrolase family 63 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 372.0
SHD2_k127_1347157_5 NADH ubiquinone oxidoreductase, 20 Kd subunit K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 321.0
SHD2_k127_1347157_6 - - - - 0.0000000000000000000000000000000000000000000000000000005688 203.0
SHD2_k127_1347157_7 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000009987 182.0
SHD2_k127_1347157_8 PFAM Rieske 2Fe-2S K00363 - 1.7.1.15 0.0000000000000000000000000000000006967 134.0
SHD2_k127_1347157_9 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000004796 137.0
SHD2_k127_1362017_0 ABC transporter, transmembrane K18889 - - 4.302e-243 762.0
SHD2_k127_1362017_1 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 540.0
SHD2_k127_1362017_2 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 418.0
SHD2_k127_1362017_3 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004965 250.0
SHD2_k127_1362017_4 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000000001451 213.0
SHD2_k127_1362017_5 - - - - 0.00000000000000000000000000000000000000000000000000000000001752 219.0
SHD2_k127_1362017_6 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000002147 193.0
SHD2_k127_1362017_7 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000003044 169.0
SHD2_k127_1362017_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000001252 142.0
SHD2_k127_1362017_9 Belongs to the universal stress protein A family - - - 0.000000000000000000000008179 112.0
SHD2_k127_1362476_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009861 581.0
SHD2_k127_1362476_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008604 465.0
SHD2_k127_1362476_10 Lamin Tail Domain - - - 0.00003763 52.0
SHD2_k127_1362476_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 410.0
SHD2_k127_1362476_3 Phosphate transport system permease protein PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 397.0
SHD2_k127_1362476_4 Belongs to the acetokinase family K00929 - 2.7.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 367.0
SHD2_k127_1362476_5 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 311.0
SHD2_k127_1362476_6 PFAM Phosphate acetyl butaryl transferase K00634 - 2.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000001933 263.0
SHD2_k127_1362476_7 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001015 270.0
SHD2_k127_1362476_8 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000000000000000000000000000000003633 176.0
SHD2_k127_1362476_9 Transcriptional regulator, MerR family K00558,K13639,K13640 - 2.1.1.37 0.000000000000000000000000000505 118.0
SHD2_k127_1423475_0 AcrB/AcrD/AcrF family K15726 - - 5.044e-221 703.0
SHD2_k127_1423475_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000001078 215.0
SHD2_k127_1515068_0 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 0.0 1653.0
SHD2_k127_1515068_1 Sortilin, neurotensin receptor 3, - - - 0.0 1346.0
SHD2_k127_1515068_10 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 479.0
SHD2_k127_1515068_11 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 448.0
SHD2_k127_1515068_12 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 433.0
SHD2_k127_1515068_13 Serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000711 428.0
SHD2_k127_1515068_14 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 427.0
SHD2_k127_1515068_15 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 432.0
SHD2_k127_1515068_17 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003663 250.0
SHD2_k127_1515068_18 Superoxide dismutase K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000313 183.0
SHD2_k127_1515068_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1307.0
SHD2_k127_1515068_20 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000009504 161.0
SHD2_k127_1515068_21 EVE domain - - - 0.00000000000000000000000000000000000000009196 153.0
SHD2_k127_1515068_22 Nicotinamide mononucleotide transporter K03811 - - 0.000000000000000000000000000000000000001189 154.0
SHD2_k127_1515068_23 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000009675 149.0
SHD2_k127_1515068_24 cheY-homologous receiver domain - - - 0.00000000000000000000000000000006261 131.0
SHD2_k127_1515068_25 - - - - 0.0000000000000000000006186 96.0
SHD2_k127_1515068_26 Tetratricopeptide repeat - - - 0.00000000000000001087 89.0
SHD2_k127_1515068_27 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000009913 58.0
SHD2_k127_1515068_3 Beta-eliminating lyase K01667 - 4.1.99.1 5.638e-240 748.0
SHD2_k127_1515068_4 Ami_3 K01448 - 3.5.1.28 1.272e-230 736.0
SHD2_k127_1515068_5 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 595.0
SHD2_k127_1515068_6 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 521.0
SHD2_k127_1515068_7 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 534.0
SHD2_k127_1515068_8 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 522.0
SHD2_k127_1515068_9 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 483.0
SHD2_k127_160259_0 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0 2311.0
SHD2_k127_160259_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 7.709e-236 741.0
SHD2_k127_160259_2 glutamate synthase K00266 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 372.0
SHD2_k127_168637_0 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 407.0
SHD2_k127_168637_1 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000001388 71.0
SHD2_k127_168637_3 HD domain - - - 0.0006794 49.0
SHD2_k127_1752827_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 1e-323 1005.0
SHD2_k127_1752827_1 Protein of unknown function (DUF2891) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 482.0
SHD2_k127_1752827_2 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 434.0
SHD2_k127_1752827_3 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000002601 166.0
SHD2_k127_1752827_4 ABC transporter, ATP-binding protein - - - 0.0000000000000000000000000000000000000003115 152.0
SHD2_k127_1901978_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1079.0
SHD2_k127_1901978_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.0 1035.0
SHD2_k127_1901978_10 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 584.0
SHD2_k127_1901978_11 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 573.0
SHD2_k127_1901978_12 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 539.0
SHD2_k127_1901978_13 May be involved in the transport of PQQ or its precursor to the periplasm K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 520.0
SHD2_k127_1901978_14 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 490.0
SHD2_k127_1901978_15 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 478.0
SHD2_k127_1901978_16 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 434.0
SHD2_k127_1901978_17 Peptidase, M20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 417.0
SHD2_k127_1901978_18 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 386.0
SHD2_k127_1901978_19 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 371.0
SHD2_k127_1901978_2 Carboxyl transferase domain - - - 1.147e-282 878.0
SHD2_k127_1901978_20 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004126 344.0
SHD2_k127_1901978_21 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 325.0
SHD2_k127_1901978_22 LssY C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 328.0
SHD2_k127_1901978_23 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 319.0
SHD2_k127_1901978_24 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 312.0
SHD2_k127_1901978_25 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 316.0
SHD2_k127_1901978_26 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 305.0
SHD2_k127_1901978_27 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 302.0
SHD2_k127_1901978_28 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 288.0
SHD2_k127_1901978_29 Domain of unknown function (DUF1906) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001985 262.0
SHD2_k127_1901978_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 6.882e-254 792.0
SHD2_k127_1901978_31 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003524 251.0
SHD2_k127_1901978_32 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000002601 242.0
SHD2_k127_1901978_33 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000001847 226.0
SHD2_k127_1901978_34 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000002265 223.0
SHD2_k127_1901978_35 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000006794 220.0
SHD2_k127_1901978_36 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000009216 207.0
SHD2_k127_1901978_37 PFAM thioesterase superfamily K07107 - - 0.0000000000000000000000000000000000000000000000001385 184.0
SHD2_k127_1901978_38 Enoyl-CoA hydratase K01782,K01825 GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.0000000000000000000000000000000000000000000000011 181.0
SHD2_k127_1901978_39 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.000000000000000000000000000000000000000000000003838 174.0
SHD2_k127_1901978_4 Aromatic amino acid lyase K01745 - 4.3.1.3 3.482e-219 692.0
SHD2_k127_1901978_40 - - - - 0.00000000000000000000000000000000000000001925 164.0
SHD2_k127_1901978_41 TIGRFAM DNA binding domain protein, excisionase family - - - 0.0000000000000000000000000000000000000002485 153.0
SHD2_k127_1901978_42 - - - - 0.000000000000000000000000000000000000006646 147.0
SHD2_k127_1901978_43 Putative peptidoglycan binding domain - - - 0.000000000000000000000000000000000001762 145.0
SHD2_k127_1901978_44 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000004556 142.0
SHD2_k127_1901978_45 Sel1-like repeats. K07126 - - 0.00000000000000000000000000000000002956 146.0
SHD2_k127_1901978_46 DoxX - - - 0.0000000000000000000000000000000376 131.0
SHD2_k127_1901978_47 Predicted membrane protein (DUF2127) - - - 0.00000000000000000000000000000321 128.0
SHD2_k127_1901978_48 Histidine kinase - - - 0.00000000000000000000000000005473 120.0
SHD2_k127_1901978_49 VanZ like family - - - 0.000000000000000000000000004303 117.0
SHD2_k127_1901978_5 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 1.566e-215 682.0
SHD2_k127_1901978_51 - - - - 0.0000000000000000000000001275 113.0
SHD2_k127_1901978_52 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000000000000001114 108.0
SHD2_k127_1901978_53 Sigma-70, region 4 K03088 - - 0.0000000000000000000004486 99.0
SHD2_k127_1901978_55 Pas domain - - - 0.000000000000000005864 91.0
SHD2_k127_1901978_56 Beta-lactamase - - - 0.00005127 46.0
SHD2_k127_1901978_57 - - - - 0.0006314 45.0
SHD2_k127_1901978_6 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 2.269e-207 655.0
SHD2_k127_1901978_7 Amidohydrolase family - - - 6.697e-207 661.0
SHD2_k127_1901978_8 Trypsin K04771 - 3.4.21.107 6.556e-202 643.0
SHD2_k127_1901978_9 PFAM Alcohol dehydrogenase GroES-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 580.0
SHD2_k127_1940044_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1459.0
SHD2_k127_1940044_1 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 437.0
SHD2_k127_1940044_2 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 381.0
SHD2_k127_1940044_3 Belongs to the helicase family. UvrD subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007563 286.0
SHD2_k127_1982641_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1034.0
SHD2_k127_1982641_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 3.74e-318 986.0
SHD2_k127_1982641_2 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 523.0
SHD2_k127_1982641_3 TatD related DNase K03424 - - 0.000000000000000000001417 95.0
SHD2_k127_2022950_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1523.0
SHD2_k127_2022950_1 CoA binding domain K09181 - - 0.0 1366.0
SHD2_k127_2022950_10 FMN-dependent dehydrogenase K16422 - 1.1.3.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 378.0
SHD2_k127_2022950_11 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 336.0
SHD2_k127_2022950_12 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000000000004091 154.0
SHD2_k127_2022950_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000003801 139.0
SHD2_k127_2022950_15 aminopeptidase activity - - - 0.0000000000000009342 91.0
SHD2_k127_2022950_16 lactoylglutathione lyase activity - - - 0.000000000000006743 80.0
SHD2_k127_2022950_17 Response regulator, receiver - - - 0.000000000001007 73.0
SHD2_k127_2022950_18 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000008018 62.0
SHD2_k127_2022950_19 Cysteine-rich secretory protein family - - - 0.00000197 61.0
SHD2_k127_2022950_2 PFAM TonB-dependent Receptor Plug - - - 0.0 1234.0
SHD2_k127_2022950_3 Belongs to the TPP enzyme family K00156 - 1.2.5.1 9.99e-268 835.0
SHD2_k127_2022950_4 Domain of Unknown Function with PDB structure (DUF3857) - - - 8.556e-211 694.0
SHD2_k127_2022950_5 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 7.564e-196 614.0
SHD2_k127_2022950_6 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 612.0
SHD2_k127_2022950_7 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 471.0
SHD2_k127_2022950_8 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 426.0
SHD2_k127_2022950_9 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 400.0
SHD2_k127_2027752_0 Lysin motif K08307 - - 4.775e-236 746.0
SHD2_k127_2027752_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009879 321.0
SHD2_k127_2027752_2 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 299.0
SHD2_k127_2104807_0 Belongs to the helicase family. UvrD subfamily - - - 8.982e-235 764.0
SHD2_k127_2104807_1 DNA repair protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 402.0
SHD2_k127_2121057_0 Tetratricopeptide repeat - - - 2.466e-278 872.0
SHD2_k127_2121057_1 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007471 519.0
SHD2_k127_2121057_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007784 306.0
SHD2_k127_2121057_3 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 294.0
SHD2_k127_2121057_4 - - - - 0.0000000000000000000000000000000000000000001392 165.0
SHD2_k127_2170656_0 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 611.0
SHD2_k127_2170656_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000001929 193.0
SHD2_k127_2170656_2 - - - - 0.0000000000000000000000000000151 135.0
SHD2_k127_2170656_3 determination of stomach left/right asymmetry - - - 0.00000004844 62.0
SHD2_k127_2219620_0 FAD linked oxidases, C-terminal domain - - - 0.0 1236.0
SHD2_k127_2219620_1 Histidine kinase K07636 - 2.7.13.3 8.261e-206 659.0
SHD2_k127_2219620_2 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004551 509.0
SHD2_k127_2219620_3 Belongs to the PstS family K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009937 425.0
SHD2_k127_2219620_4 Transcriptional regulatory protein, C terminal K02483,K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 349.0
SHD2_k127_2219620_5 Mandelate racemase muconate lactonizing enzyme - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009712,GO:0009987,GO:0016853,GO:0016854,GO:0016872,GO:0018850,GO:0018958,GO:0019336,GO:0019439,GO:0019614,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044248,GO:0046872,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901575,GO:1901615,GO:1901616 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008668 270.0
SHD2_k127_2219620_6 negative regulation of phosphate transmembrane transport K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000000000002874 240.0
SHD2_k127_2219620_7 mandelate racemase muconate lactonizing - - - 0.0000000000000000000265 93.0
SHD2_k127_2226532_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1183.0
SHD2_k127_2226532_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1013.0
SHD2_k127_2226532_10 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 440.0
SHD2_k127_2226532_11 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 439.0
SHD2_k127_2226532_12 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 383.0
SHD2_k127_2226532_13 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 370.0
SHD2_k127_2226532_14 dUTPase K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 361.0
SHD2_k127_2226532_15 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 350.0
SHD2_k127_2226532_16 ATP-independent chaperone mediated protein folding K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 355.0
SHD2_k127_2226532_17 DoxX - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 344.0
SHD2_k127_2226532_18 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 342.0
SHD2_k127_2226532_19 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 342.0
SHD2_k127_2226532_2 ABC transporter K11085 - - 7.413e-254 796.0
SHD2_k127_2226532_20 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 345.0
SHD2_k127_2226532_21 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 344.0
SHD2_k127_2226532_22 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 296.0
SHD2_k127_2226532_23 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 294.0
SHD2_k127_2226532_24 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006595 291.0
SHD2_k127_2226532_25 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 293.0
SHD2_k127_2226532_26 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 286.0
SHD2_k127_2226532_27 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004911 294.0
SHD2_k127_2226532_28 PFAM transposase IS116 IS110 IS902 family protein K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 292.0
SHD2_k127_2226532_29 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002591 294.0
SHD2_k127_2226532_3 GGDEF domain - - - 2.521e-233 749.0
SHD2_k127_2226532_30 GlcNAc-PI de-N-acetylase K22135 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002524 278.0
SHD2_k127_2226532_31 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005183 279.0
SHD2_k127_2226532_32 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000001501 270.0
SHD2_k127_2226532_33 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000225 267.0
SHD2_k127_2226532_34 Ribosomal subunit interface protein K05808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001129 253.0
SHD2_k127_2226532_35 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000723 235.0
SHD2_k127_2226532_36 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000001595 233.0
SHD2_k127_2226532_37 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000000000000000000000223 228.0
SHD2_k127_2226532_38 gluconolactonase activity K14274 - - 0.0000000000000000000000000000000000000000000000000000000000000001038 246.0
SHD2_k127_2226532_39 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000000000000004172 216.0
SHD2_k127_2226532_4 PFAM peptidase M28 - - - 2.024e-200 639.0
SHD2_k127_2226532_40 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000001136 214.0
SHD2_k127_2226532_41 - - - - 0.00000000000000000000000000000000000000000000000000000003667 215.0
SHD2_k127_2226532_42 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000002923 183.0
SHD2_k127_2226532_43 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000005649 174.0
SHD2_k127_2226532_44 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000000000000000000000000431 169.0
SHD2_k127_2226532_45 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000006609 174.0
SHD2_k127_2226532_46 Domain of unknown function (DUF2520) - - - 0.00000000000000000000000000000000000000000001839 174.0
SHD2_k127_2226532_47 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.00000000000000000000000000000000000000009344 156.0
SHD2_k127_2226532_48 Hfq protein - - - 0.000000000000000000000000000000000000009939 149.0
SHD2_k127_2226532_49 ATP-independent chaperone mediated protein folding K02005 - - 0.000000000000000000000000000000000009286 140.0
SHD2_k127_2226532_5 PFAM peptidase M61 - - - 7.919e-198 637.0
SHD2_k127_2226532_50 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000000000006063 127.0
SHD2_k127_2226532_51 COG3547 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000002447 126.0
SHD2_k127_2226532_52 Belongs to the serpin family K13963 - - 0.0000000000000000000000000000004831 128.0
SHD2_k127_2226532_53 - - - - 0.00000000000000000000000000002123 121.0
SHD2_k127_2226532_54 - - - - 0.0000000000000000000005473 96.0
SHD2_k127_2226532_55 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000174 85.0
SHD2_k127_2226532_56 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000004197 86.0
SHD2_k127_2226532_57 - - - - 0.0000000000000003308 89.0
SHD2_k127_2226532_58 SnoaL-like domain - - - 0.000000000000001863 85.0
SHD2_k127_2226532_6 Aminotransferase class-III - - - 6.181e-196 620.0
SHD2_k127_2226532_60 Phage integrase family - - - 0.00000000000001171 79.0
SHD2_k127_2226532_61 Belongs to the UPF0109 family K06960 - - 0.00000000000003872 76.0
SHD2_k127_2226532_62 Belongs to the serpin family K13963 - - 0.00000000000008506 77.0
SHD2_k127_2226532_64 Major Facilitator Superfamily - - - 0.00000000005553 64.0
SHD2_k127_2226532_65 - - - - 0.000003882 58.0
SHD2_k127_2226532_68 Belongs to the serpin family K05579,K13963 GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005615,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0043086,GO:0044092,GO:0044421,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772 1.6.5.3 0.0001307 48.0
SHD2_k127_2226532_69 PFAM S-layer domain protein - - - 0.0004742 44.0
SHD2_k127_2226532_7 Phosphoesterase family - - - 5.443e-194 627.0
SHD2_k127_2226532_8 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 554.0
SHD2_k127_2226532_9 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 478.0
SHD2_k127_2261709_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1135.0
SHD2_k127_2261709_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895,K01908 GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0050218,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224 6.2.1.1,6.2.1.17 5.904e-307 951.0
SHD2_k127_2261709_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009365 540.0
SHD2_k127_2261709_11 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 499.0
SHD2_k127_2261709_12 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 486.0
SHD2_k127_2261709_13 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 480.0
SHD2_k127_2261709_14 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 472.0
SHD2_k127_2261709_15 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000651 436.0
SHD2_k127_2261709_16 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009716 433.0
SHD2_k127_2261709_17 sh3 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000797 422.0
SHD2_k127_2261709_18 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 411.0
SHD2_k127_2261709_19 cyclic nucleotide-binding K01420,K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 405.0
SHD2_k127_2261709_2 Prolyl oligopeptidase - - - 1.744e-260 820.0
SHD2_k127_2261709_20 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 393.0
SHD2_k127_2261709_21 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 353.0
SHD2_k127_2261709_22 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 361.0
SHD2_k127_2261709_23 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 357.0
SHD2_k127_2261709_24 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 343.0
SHD2_k127_2261709_25 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 344.0
SHD2_k127_2261709_26 COGs COG4299 conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 319.0
SHD2_k127_2261709_27 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 311.0
SHD2_k127_2261709_28 photoreceptor activity K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 313.0
SHD2_k127_2261709_29 synthase K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 300.0
SHD2_k127_2261709_3 glycolate transport K14393 - - 5.229e-232 728.0
SHD2_k127_2261709_30 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002413 286.0
SHD2_k127_2261709_31 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006008 268.0
SHD2_k127_2261709_32 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009201 262.0
SHD2_k127_2261709_33 Pyruvate ferredoxin/flavodoxin oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000004335 253.0
SHD2_k127_2261709_34 DREV methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000004928 234.0
SHD2_k127_2261709_35 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000000000000000000000000000002425 219.0
SHD2_k127_2261709_36 Peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000000004235 208.0
SHD2_k127_2261709_37 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000527 202.0
SHD2_k127_2261709_38 4Fe-4S binding domain K00176 - 1.2.7.3 0.000000000000000000000000000000000000003223 147.0
SHD2_k127_2261709_39 Sporulation and spore germination - - - 0.000000000000000000000000000000000004197 147.0
SHD2_k127_2261709_4 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - - 9.341e-224 702.0
SHD2_k127_2261709_40 Protein of unknown function, DUF485 - - - 0.000000000000000000000000000000004959 132.0
SHD2_k127_2261709_41 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000003361 114.0
SHD2_k127_2261709_42 Domain of unknown function (DUF1330) - - - 0.000000000000000000000000208 108.0
SHD2_k127_2261709_43 Response regulator, receiver - - - 0.000000000000000000000002671 107.0
SHD2_k127_2261709_44 Periplasmic or secreted lipoprotein - - - 0.000000000000000000001747 105.0
SHD2_k127_2261709_45 PFAM Septum formation initiator K05589 - - 0.000000000000000000002703 97.0
SHD2_k127_2261709_46 - - - - 0.000000000000000000009167 95.0
SHD2_k127_2261709_47 - - - - 0.00000000000000000003474 92.0
SHD2_k127_2261709_48 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000003463 79.0
SHD2_k127_2261709_49 Response regulator receiver - - - 0.000000000000003525 82.0
SHD2_k127_2261709_5 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.572e-202 639.0
SHD2_k127_2261709_50 - - - - 0.000000002387 62.0
SHD2_k127_2261709_51 PFAM Uncharacterised conserved protein UCP033563 - - - 0.0000003694 62.0
SHD2_k127_2261709_52 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000156 51.0
SHD2_k127_2261709_54 translation initiation factor activity K02004,K10939,K12257,K14393 - - 0.0003463 53.0
SHD2_k127_2261709_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 1.717e-201 635.0
SHD2_k127_2261709_7 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K17217 - 2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8 8.966e-198 621.0
SHD2_k127_2261709_8 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 587.0
SHD2_k127_2261709_9 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 561.0
SHD2_k127_2292928_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005503 518.0
SHD2_k127_2292928_1 Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000001987 115.0
SHD2_k127_2306105_0 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 483.0
SHD2_k127_2306105_1 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 401.0
SHD2_k127_2306105_10 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000007417 219.0
SHD2_k127_2306105_11 - - - - 0.000000000000000000000000000000000000000000000000003571 194.0
SHD2_k127_2306105_12 Belongs to the UPF0145 family - - - 0.00000000000000000000000000000000000000000001655 164.0
SHD2_k127_2306105_13 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000005967 126.0
SHD2_k127_2306105_14 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000003438 111.0
SHD2_k127_2306105_15 - - - - 0.000000000000000000000001573 111.0
SHD2_k127_2306105_2 nucleotide metabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 351.0
SHD2_k127_2306105_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 326.0
SHD2_k127_2306105_4 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 320.0
SHD2_k127_2306105_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 297.0
SHD2_k127_2306105_6 Protein involved in cellulose biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006448 269.0
SHD2_k127_2306105_7 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002941 251.0
SHD2_k127_2306105_8 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000000000000000000001944 218.0
SHD2_k127_2306105_9 MobA-Related Protein K07141,K19190 - 1.1.1.328,2.7.7.76 0.0000000000000000000000000000000000000000000000000000000000001144 219.0
SHD2_k127_243107_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 1.247e-255 801.0
SHD2_k127_243107_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.067e-211 676.0
SHD2_k127_2437885_0 Tetratricopeptide repeat - - - 0.0 1675.0
SHD2_k127_2437885_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1134.0
SHD2_k127_2437885_10 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 582.0
SHD2_k127_2437885_11 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 567.0
SHD2_k127_2437885_12 HELICc2 K03722 GO:0003674,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:1901360 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 548.0
SHD2_k127_2437885_13 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 545.0
SHD2_k127_2437885_14 TIGRFAM molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 416.0
SHD2_k127_2437885_15 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 390.0
SHD2_k127_2437885_16 Phosphoesterase family K01114 - 3.1.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007142 401.0
SHD2_k127_2437885_17 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 364.0
SHD2_k127_2437885_18 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 342.0
SHD2_k127_2437885_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 333.0
SHD2_k127_2437885_2 PFAM TonB-dependent Receptor Plug - - - 2.875e-256 818.0
SHD2_k127_2437885_20 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 313.0
SHD2_k127_2437885_21 metal ion transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 316.0
SHD2_k127_2437885_22 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 306.0
SHD2_k127_2437885_23 Inward rectifier potassium channel K08715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 301.0
SHD2_k127_2437885_24 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007167 278.0
SHD2_k127_2437885_25 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003386 280.0
SHD2_k127_2437885_27 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000000000004587 217.0
SHD2_k127_2437885_28 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000004358 214.0
SHD2_k127_2437885_29 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000002088 210.0
SHD2_k127_2437885_3 HD domain - - - 2.456e-245 775.0
SHD2_k127_2437885_30 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000001785 195.0
SHD2_k127_2437885_31 antisigma factor binding K04749 - - 0.0000000000000000000000000000000000000000000000000001789 188.0
SHD2_k127_2437885_32 PFAM TonB-dependent Receptor Plug - - - 0.0000000000000000000000000000000000000000000000000003307 193.0
SHD2_k127_2437885_33 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000567 185.0
SHD2_k127_2437885_34 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000000000000000000000000000006033 171.0
SHD2_k127_2437885_36 Peptidase M56 - - - 0.000000000000000000000000000000000000001561 163.0
SHD2_k127_2437885_37 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000002118 156.0
SHD2_k127_2437885_38 Peptidase M56 - - - 0.000000000000000000000000000000001826 135.0
SHD2_k127_2437885_39 - - - - 0.000000000000000000000000000000001849 139.0
SHD2_k127_2437885_4 Elongation factor SelB, winged helix K03833 - - 3.473e-236 748.0
SHD2_k127_2437885_40 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000742 133.0
SHD2_k127_2437885_41 Protein of unknown function (DUF2905) - - - 0.0000000000000000000002867 99.0
SHD2_k127_2437885_42 - - - - 0.00000000000000002511 92.0
SHD2_k127_2437885_43 Psort location CytoplasmicMembrane, score - - - 0.00000000000000002687 83.0
SHD2_k127_2437885_44 protein histidine kinase activity K07651,K07711 - 2.7.13.3 0.000000000000009408 81.0
SHD2_k127_2437885_45 Nucleotidyl transferase - - - 0.0003041 53.0
SHD2_k127_2437885_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 6.245e-233 729.0
SHD2_k127_2437885_6 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 3.322e-222 695.0
SHD2_k127_2437885_7 Glycosyl transferases group 1 - - - 1.703e-208 654.0
SHD2_k127_2437885_8 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 2.245e-199 634.0
SHD2_k127_2437885_9 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 592.0
SHD2_k127_2517584_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 607.0
SHD2_k127_2517584_1 - - - - 0.00000000000000000000000000000000000000000000000000000001193 203.0
SHD2_k127_2517584_2 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000002495 139.0
SHD2_k127_2517584_3 Single Cache domain 2 K02480 - 2.7.13.3 0.0000000000000000001303 92.0
SHD2_k127_2659215_0 heat shock protein 70 K04043,K04044 - - 1.302e-308 955.0
SHD2_k127_2659215_1 Predicted membrane protein (DUF2339) - - - 1.477e-275 892.0
SHD2_k127_2659215_10 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 570.0
SHD2_k127_2659215_11 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 551.0
SHD2_k127_2659215_12 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 489.0
SHD2_k127_2659215_13 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 495.0
SHD2_k127_2659215_14 Alcohol dehydrogenase GroES-like domain K00008,K00148,K18369 - 1.1.1.14,1.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 482.0
SHD2_k127_2659215_15 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 484.0
SHD2_k127_2659215_16 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 466.0
SHD2_k127_2659215_17 Elongator protein 3, MiaB family, Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 460.0
SHD2_k127_2659215_18 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 441.0
SHD2_k127_2659215_19 AMMECR1 K06990,K09141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 445.0
SHD2_k127_2659215_2 Carboxypeptidase regulatory-like domain - - - 2.6e-244 782.0
SHD2_k127_2659215_20 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 369.0
SHD2_k127_2659215_21 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 359.0
SHD2_k127_2659215_23 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 349.0
SHD2_k127_2659215_24 chaperone-mediated protein folding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 322.0
SHD2_k127_2659215_25 PFAM heat shock protein DnaJ K04082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 309.0
SHD2_k127_2659215_26 GGDEF domain K13590 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 310.0
SHD2_k127_2659215_27 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 304.0
SHD2_k127_2659215_28 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000118 271.0
SHD2_k127_2659215_29 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007402 263.0
SHD2_k127_2659215_3 DNA ligase D, 3'-phosphoesterase domain K01971 - 6.5.1.1 5.113e-244 770.0
SHD2_k127_2659215_30 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004381 251.0
SHD2_k127_2659215_31 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004816 243.0
SHD2_k127_2659215_32 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.000000000000000000000000000000000000000000000000000000000000000000002755 239.0
SHD2_k127_2659215_33 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000001303 231.0
SHD2_k127_2659215_34 Putative DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001765 235.0
SHD2_k127_2659215_35 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000000000000000000000000007958 198.0
SHD2_k127_2659215_36 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000002382 186.0
SHD2_k127_2659215_37 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000002978 190.0
SHD2_k127_2659215_38 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000005773 187.0
SHD2_k127_2659215_39 Histidine kinase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000007612 191.0
SHD2_k127_2659215_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 8.122e-232 725.0
SHD2_k127_2659215_40 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000000000000000001968 170.0
SHD2_k127_2659215_41 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000005117 173.0
SHD2_k127_2659215_42 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000645 162.0
SHD2_k127_2659215_43 DoxX K15977 - - 0.0000000000000000000000000000000000000004194 159.0
SHD2_k127_2659215_44 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000007585 146.0
SHD2_k127_2659215_45 Protein of unknown function (DUF1440) - - - 0.0000000000000000000000000000007021 129.0
SHD2_k127_2659215_46 Belongs to the UPF0102 family K07460 - - 0.0000000000000000000000000002138 120.0
SHD2_k127_2659215_47 - - - - 0.000000000000000000000000003298 123.0
SHD2_k127_2659215_49 FeS assembly protein IscX - - - 0.00000000000000000000000002872 109.0
SHD2_k127_2659215_5 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 2.522e-231 721.0
SHD2_k127_2659215_50 Cold shock K03704 - - 0.00000000000000000000000004648 108.0
SHD2_k127_2659215_51 - - - - 0.0000000000000000000005489 108.0
SHD2_k127_2659215_52 - - - - 0.000000000000000000001445 99.0
SHD2_k127_2659215_53 - - - - 0.000000000000000001569 97.0
SHD2_k127_2659215_54 YCII-related domain - - - 0.000000000000000004513 93.0
SHD2_k127_2659215_55 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000002137 75.0
SHD2_k127_2659215_56 - - - - 0.0000000002832 65.0
SHD2_k127_2659215_57 Chaperone - - - 0.000000001182 68.0
SHD2_k127_2659215_58 acyl carrier protein - - - 0.000000002365 61.0
SHD2_k127_2659215_59 Cna B domain protein - - - 0.00000000435 70.0
SHD2_k127_2659215_6 Aminotransferase class-III K00823 - 2.6.1.19 2.385e-223 701.0
SHD2_k127_2659215_60 PEP-CTERM system TPR-repeat lipoprotein - - - 0.000008637 59.0
SHD2_k127_2659215_7 Carbon starvation protein K06200 - - 7.442e-209 666.0
SHD2_k127_2659215_8 Sulfate permease family K03321 - - 1.422e-205 661.0
SHD2_k127_2659215_9 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 584.0
SHD2_k127_2688844_0 hydrolase, family 3 K05349 - 3.2.1.21 8.746e-259 820.0
SHD2_k127_2688844_1 D-xylose transmembrane transport K10543 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015749,GO:0015750,GO:0015753,GO:0019321,GO:0030246,GO:0030288,GO:0030313,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0042732,GO:0044238,GO:0044281,GO:0044464,GO:0048029,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 522.0
SHD2_k127_2688844_2 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 443.0
SHD2_k127_2688844_3 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000003544 189.0
SHD2_k127_2688844_4 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000004522 170.0
SHD2_k127_2688844_5 CHAT domain - - - 0.0000000000000000000000000142 122.0
SHD2_k127_2688844_6 ATPases associated with a variety of cellular activities K10548 - 3.6.3.17 0.0000000000000004326 84.0
SHD2_k127_2737871_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1218.0
SHD2_k127_2737871_1 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 559.0
SHD2_k127_2737871_10 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000001813 203.0
SHD2_k127_2737871_11 response to antibiotic - - - 0.00000000000000000000000000000000000000000000000000001341 199.0
SHD2_k127_2737871_12 - - - - 0.00000000000000000000000000000000000000000000000004759 182.0
SHD2_k127_2737871_13 - - - - 0.0000000000000000000000000000000000000000000000002136 184.0
SHD2_k127_2737871_14 Cupin domain - - - 0.00000000000000000000000000000000000000000000006793 171.0
SHD2_k127_2737871_15 PFAM Cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000001539 172.0
SHD2_k127_2737871_16 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000000001212 166.0
SHD2_k127_2737871_17 - - - - 0.0000000000000000000000000000000000000000001229 165.0
SHD2_k127_2737871_18 Rubrerythrin - - - 0.0000000000000000000000000000000000000004434 155.0
SHD2_k127_2737871_19 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000000000000116 148.0
SHD2_k127_2737871_2 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 571.0
SHD2_k127_2737871_20 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000001018 142.0
SHD2_k127_2737871_21 Mov34 MPN PAD-1 - - - 0.000000000000000000000000000000006365 133.0
SHD2_k127_2737871_22 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000002062 129.0
SHD2_k127_2737871_23 DoxX-like family - - - 0.00000000000000000000000000113 116.0
SHD2_k127_2737871_24 response to antibiotic - - - 0.00000000000000000000000002505 123.0
SHD2_k127_2737871_25 PQ loop repeat K15383 - - 0.00000000000000000000000005572 109.0
SHD2_k127_2737871_26 response regulator, receiver - - - 0.00000000000000000000001566 105.0
SHD2_k127_2737871_28 Psort location CytoplasmicMembrane, score - - - 0.00000032 61.0
SHD2_k127_2737871_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 551.0
SHD2_k127_2737871_31 Pkd domain containing protein K20276 - - 0.0002596 52.0
SHD2_k127_2737871_4 PFAM Mur ligase K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 477.0
SHD2_k127_2737871_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 448.0
SHD2_k127_2737871_6 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 334.0
SHD2_k127_2737871_7 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 335.0
SHD2_k127_2737871_8 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 327.0
SHD2_k127_2737871_9 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000007426 241.0
SHD2_k127_2845811_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1180.0
SHD2_k127_2845811_1 Fibronectin type III-like domain K05349 - 3.2.1.21 1.137e-269 850.0
SHD2_k127_2845811_10 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 359.0
SHD2_k127_2845811_11 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 325.0
SHD2_k127_2845811_12 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 298.0
SHD2_k127_2845811_13 PFAM Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000607 280.0
SHD2_k127_2845811_14 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000007274 261.0
SHD2_k127_2845811_15 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001448 244.0
SHD2_k127_2845811_16 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001527 246.0
SHD2_k127_2845811_17 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000000000000001096 230.0
SHD2_k127_2845811_18 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000002516 175.0
SHD2_k127_2845811_19 MarR family - - - 0.000000000000000000000000000000000000001183 156.0
SHD2_k127_2845811_2 Voltage gated chloride channel - - - 6.563e-259 810.0
SHD2_k127_2845811_20 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000001748 79.0
SHD2_k127_2845811_21 Protein of unknown function (DUF3298) - - - 0.00000000794 67.0
SHD2_k127_2845811_22 Carboxypeptidase regulatory-like domain - - - 0.00004611 49.0
SHD2_k127_2845811_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 1.962e-227 714.0
SHD2_k127_2845811_4 PFAM TonB-dependent Receptor - - - 9.391e-224 733.0
SHD2_k127_2845811_5 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 454.0
SHD2_k127_2845811_6 lipoprotein localization to outer membrane K02004,K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 437.0
SHD2_k127_2845811_7 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 434.0
SHD2_k127_2845811_8 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 424.0
SHD2_k127_2845811_9 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 412.0
SHD2_k127_2886078_0 Belongs to the BshC family K22136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 496.0
SHD2_k127_2886078_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 300.0
SHD2_k127_2886078_2 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000004962 206.0
SHD2_k127_2886078_3 - - - - 0.0000000000000000000000000000000000000006704 151.0
SHD2_k127_3085520_0 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 1.325e-256 808.0
SHD2_k127_3085520_1 amino acid K03294 - - 3.213e-252 785.0
SHD2_k127_3085520_10 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006049 511.0
SHD2_k127_3085520_11 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 471.0
SHD2_k127_3085520_12 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 466.0
SHD2_k127_3085520_13 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 392.0
SHD2_k127_3085520_14 TrkA-C domain K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 383.0
SHD2_k127_3085520_15 CHASE3 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 358.0
SHD2_k127_3085520_16 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008665 332.0
SHD2_k127_3085520_18 ribonuclease, Rne Rng family K08301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 346.0
SHD2_k127_3085520_19 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009368 278.0
SHD2_k127_3085520_2 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 1.044e-247 771.0
SHD2_k127_3085520_20 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003748 267.0
SHD2_k127_3085520_21 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000001059 248.0
SHD2_k127_3085520_22 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000008692 224.0
SHD2_k127_3085520_23 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000002743 221.0
SHD2_k127_3085520_24 - - - - 0.0000000000000000000000000000000000000000000000000000000000000534 223.0
SHD2_k127_3085520_25 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000005875 215.0
SHD2_k127_3085520_26 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000003005 203.0
SHD2_k127_3085520_27 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000000003176 195.0
SHD2_k127_3085520_28 PFAM Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000000000000000002237 186.0
SHD2_k127_3085520_29 RecX family K03565 - - 0.00000000000000000000000000000000000000000000000689 178.0
SHD2_k127_3085520_3 ABC transporter K15738 - - 1.648e-241 763.0
SHD2_k127_3085520_30 carbon utilization K02664,K02665,K12280 - - 0.0000000000000000000000000000000000000000000000126 179.0
SHD2_k127_3085520_31 PFAM Fimbrial assembly family protein K02663 - - 0.000000000000000000000000000000000000000000008672 169.0
SHD2_k127_3085520_32 DinB family - - - 0.000000000000000000000000000000003056 134.0
SHD2_k127_3085520_33 Helix-turn-helix domain - - - 0.0000000000000000000000000000005715 126.0
SHD2_k127_3085520_35 integral membrane protein - - - 0.00000000000000000000000007625 113.0
SHD2_k127_3085520_37 - - - - 0.0000000000000004847 85.0
SHD2_k127_3085520_38 Protein of unknown function (DUF3106) - - - 0.000043 53.0
SHD2_k127_3085520_4 Secretin and TonB N terminus short domain K02666 - - 3.738e-237 758.0
SHD2_k127_3085520_5 amino acid K03294 - - 8.907e-234 734.0
SHD2_k127_3085520_6 Type II/IV secretion system protein K02669 - - 4.272e-206 645.0
SHD2_k127_3085520_7 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009683 553.0
SHD2_k127_3085520_8 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 541.0
SHD2_k127_3085520_9 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 522.0
SHD2_k127_30923_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 1e-322 997.0
SHD2_k127_30923_1 Peptidase family M13 - - - 5.458e-290 906.0
SHD2_k127_30923_10 Organic Anion Transporter Polypeptide (OATP) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006809 528.0
SHD2_k127_30923_11 MgtE intracellular N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 507.0
SHD2_k127_30923_12 PFAM natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 504.0
SHD2_k127_30923_13 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 499.0
SHD2_k127_30923_14 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 475.0
SHD2_k127_30923_15 TIGRFAM hopanoid-associated sugar epimerase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 446.0
SHD2_k127_30923_16 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 433.0
SHD2_k127_30923_17 Squalene/phytoene synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008493 430.0
SHD2_k127_30923_18 PFAM Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 423.0
SHD2_k127_30923_19 PFAM Squalene phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 372.0
SHD2_k127_30923_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnJ - - - 2.045e-261 811.0
SHD2_k127_30923_20 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 349.0
SHD2_k127_30923_21 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 331.0
SHD2_k127_30923_22 MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 317.0
SHD2_k127_30923_23 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 321.0
SHD2_k127_30923_24 Outer membrane lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 308.0
SHD2_k127_30923_25 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000324 278.0
SHD2_k127_30923_26 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009334 259.0
SHD2_k127_30923_27 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000174 225.0
SHD2_k127_30923_28 TonB C terminal K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000008717 227.0
SHD2_k127_30923_29 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K19270 - 3.1.3.23 0.000000000000000000000000000000000000000000000000000000000000007795 222.0
SHD2_k127_30923_3 May be involved in recombinational repair of damaged DNA K03631 - - 1.735e-239 752.0
SHD2_k127_30923_30 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000000000000000000000000000000000000000000000145 217.0
SHD2_k127_30923_31 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000004501 207.0
SHD2_k127_30923_32 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000000000000000000000000000000000000000000000000006733 199.0
SHD2_k127_30923_33 membrane - - - 0.00000000000000000000000000000000000000000953 158.0
SHD2_k127_30923_35 hydroperoxide reductase activity - - - 0.00000000000000000000000000000000000005298 143.0
SHD2_k127_30923_36 membrane - - - 0.0000000000000000000000000000000121 133.0
SHD2_k127_30923_37 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000007431 108.0
SHD2_k127_30923_38 Phosphorylase superfamily K01243 - 3.2.2.9 0.0000000000000000000000000842 118.0
SHD2_k127_30923_39 - - - - 0.0000000000009199 77.0
SHD2_k127_30923_4 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.028e-202 637.0
SHD2_k127_30923_40 - - - - 0.0000000003092 62.0
SHD2_k127_30923_5 FAD dependent oxidoreductase K00514 - 1.3.5.6 1.009e-201 639.0
SHD2_k127_30923_6 WD40-like Beta Propeller K03641 - - 2.86e-198 626.0
SHD2_k127_30923_7 Zinc-binding dehydrogenase K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 578.0
SHD2_k127_30923_8 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 567.0
SHD2_k127_30923_9 PFAM Alcohol dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 529.0
SHD2_k127_3096714_0 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 456.0
SHD2_k127_3096714_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 364.0
SHD2_k127_3096714_2 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 319.0
SHD2_k127_3096714_3 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 293.0
SHD2_k127_3096714_5 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000001334 100.0
SHD2_k127_3096714_6 - - - - 0.00001692 55.0
SHD2_k127_3101052_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K07516 - 1.1.1.35 0.0 1251.0
SHD2_k127_3101052_1 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 6.191e-273 850.0
SHD2_k127_3101052_10 EthD domain - - - 0.00000000000000000000000000000001144 129.0
SHD2_k127_3101052_11 - - - - 0.00000000000000000000000000006884 119.0
SHD2_k127_3101052_12 YtxH-like protein - - - 0.00004506 51.0
SHD2_k127_3101052_13 - - - - 0.00005941 48.0
SHD2_k127_3101052_2 Thiolase, C-terminal domain K00632 - 2.3.1.16 3.023e-202 636.0
SHD2_k127_3101052_3 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 573.0
SHD2_k127_3101052_4 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 532.0
SHD2_k127_3101052_5 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 422.0
SHD2_k127_3101052_6 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 387.0
SHD2_k127_3101052_7 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 374.0
SHD2_k127_3101052_8 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000008547 191.0
SHD2_k127_3101052_9 RNA-binding S4 domain protein K04762 - - 0.00000000000000000000000000000000000000000000007332 173.0
SHD2_k127_3135958_0 Domain of unknown function (DUF4968) K01811 - 3.2.1.177 0.0 1089.0
SHD2_k127_3135958_1 Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 1.096e-257 812.0
SHD2_k127_3135958_2 Pfam:DUF303 K05970 - 3.1.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 433.0
SHD2_k127_3135958_3 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 346.0
SHD2_k127_3180817_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007674 477.0
SHD2_k127_3180817_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000006467 205.0
SHD2_k127_3180817_2 BlaR1 peptidase M56 - - - 0.00000005194 60.0
SHD2_k127_3183535_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 2.679e-217 690.0
SHD2_k127_3183535_1 - - - - 0.00000000000000000000000000000000000000000000000000000009625 198.0
SHD2_k127_3183535_2 RDD family - - - 0.000000000000000000000008154 108.0
SHD2_k127_3183535_3 RDD family - - - 0.000000007253 61.0
SHD2_k127_3269593_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 7.04e-232 721.0
SHD2_k127_3269593_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 3.385e-214 683.0
SHD2_k127_3269593_10 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000003283 240.0
SHD2_k127_3269593_11 Regulatory protein - - - 0.0000000000000000000000000000000000000000006132 161.0
SHD2_k127_3269593_12 - - - - 0.000000000000000000000000000000001765 136.0
SHD2_k127_3269593_13 Glycosyl transferase family group 2 K16557 - - 0.0000000000000000000000000006572 126.0
SHD2_k127_3269593_14 - - - - 0.000000000000000000000002723 114.0
SHD2_k127_3269593_15 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000001156 96.0
SHD2_k127_3269593_16 Penicillin-binding protein K12555,K18770 - 2.4.1.129,3.4.16.4 0.00002112 55.0
SHD2_k127_3269593_17 - - - - 0.0001629 52.0
SHD2_k127_3269593_2 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 606.0
SHD2_k127_3269593_3 PFAM Ribonuclease II K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 560.0
SHD2_k127_3269593_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 521.0
SHD2_k127_3269593_5 sulfuric ester hydrolase activity K03760,K06349,K19353 GO:0008150,GO:0022603,GO:0042173,GO:0043937,GO:0043938,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 2.7.8.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 517.0
SHD2_k127_3269593_6 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 369.0
SHD2_k127_3269593_7 ATP-dependent DNA helicase RecQ K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 375.0
SHD2_k127_3269593_8 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 329.0
SHD2_k127_3269593_9 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001916 264.0
SHD2_k127_3271485_0 Histidine kinase - - - 0.0 1360.0
SHD2_k127_3271485_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 1.186e-265 824.0
SHD2_k127_3271485_10 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 412.0
SHD2_k127_3271485_11 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 387.0
SHD2_k127_3271485_12 Belongs to the MlaE permease family K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 378.0
SHD2_k127_3271485_13 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 358.0
SHD2_k127_3271485_14 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 355.0
SHD2_k127_3271485_15 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 313.0
SHD2_k127_3271485_16 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000577 273.0
SHD2_k127_3271485_17 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001203 276.0
SHD2_k127_3271485_18 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001613 247.0
SHD2_k127_3271485_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004064 256.0
SHD2_k127_3271485_2 Peptidase M56 - - - 7.194e-230 726.0
SHD2_k127_3271485_20 Transposase IS116/IS110/IS902 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004311 249.0
SHD2_k127_3271485_21 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009669 247.0
SHD2_k127_3271485_22 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000000006648 192.0
SHD2_k127_3271485_23 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000002994 195.0
SHD2_k127_3271485_24 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000003857 192.0
SHD2_k127_3271485_25 methyltransferase activity - - - 0.0000000000000000000000000002505 120.0
SHD2_k127_3271485_26 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000002181 105.0
SHD2_k127_3271485_27 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000001161 96.0
SHD2_k127_3271485_3 response regulator, receiver - - - 4.198e-220 691.0
SHD2_k127_3271485_31 Domain of unknown function (DUF305) - - - 0.0000000002851 72.0
SHD2_k127_3271485_32 Putative transmembrane protein (PGPGW) - - - 0.0000002326 55.0
SHD2_k127_3271485_33 - - - - 0.000007225 49.0
SHD2_k127_3271485_4 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 2.104e-217 682.0
SHD2_k127_3271485_5 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 580.0
SHD2_k127_3271485_6 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006517 566.0
SHD2_k127_3271485_7 Efflux transporter, RND family, MFP subunit K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 548.0
SHD2_k127_3271485_8 penicillin-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 514.0
SHD2_k127_3271485_9 Domain of unknown function (DUF3471) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 504.0
SHD2_k127_3341428_0 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 0.0 1138.0
SHD2_k127_3341428_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 556.0
SHD2_k127_3341428_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 402.0
SHD2_k127_3341428_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 341.0
SHD2_k127_3341428_4 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000196 288.0
SHD2_k127_3341428_5 Domain of Unknown function (DUF542) K07322 - - 0.00000000000000000000000000000000000000000000000000000000000000000004965 239.0
SHD2_k127_3341428_6 Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000008779 168.0
SHD2_k127_3341428_7 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000001736 113.0
SHD2_k127_3341428_8 protein transport across the cell outer membrane K02453 - - 0.00000000001428 73.0
SHD2_k127_3344129_0 Carboxypeptidase regulatory-like domain - - - 0.0 1253.0
SHD2_k127_3344129_1 CarboxypepD_reg-like domain - - - 1.526e-244 775.0
SHD2_k127_3344129_10 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000000000009509 189.0
SHD2_k127_3344129_11 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000000000000000000000000000006127 164.0
SHD2_k127_3344129_12 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000003452 160.0
SHD2_k127_3344129_13 - - - - 0.00000000000000000000000000000000000000007784 151.0
SHD2_k127_3344129_14 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000004658 126.0
SHD2_k127_3344129_15 response regulator, receiver - - - 0.0000000000000000000000004311 111.0
SHD2_k127_3344129_16 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000000001024 94.0
SHD2_k127_3344129_17 Belongs to the BI1 family K06890 - - 0.0000000000002775 80.0
SHD2_k127_3344129_18 - - - - 0.000952 47.0
SHD2_k127_3344129_2 PFAM Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007904 527.0
SHD2_k127_3344129_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 450.0
SHD2_k127_3344129_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 424.0
SHD2_k127_3344129_5 Cytochrome c K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 392.0
SHD2_k127_3344129_6 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 333.0
SHD2_k127_3344129_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001885 276.0
SHD2_k127_3344129_8 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002328 273.0
SHD2_k127_3344129_9 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000008748 210.0
SHD2_k127_3372192_0 Histidine kinase K02482,K03557 - 2.7.13.3 0.0 1068.0
SHD2_k127_3372192_1 Protein of unknown function (DUF1343) - - - 6.765e-298 933.0
SHD2_k127_3372192_10 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000307 577.0
SHD2_k127_3372192_11 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 565.0
SHD2_k127_3372192_12 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 508.0
SHD2_k127_3372192_13 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 493.0
SHD2_k127_3372192_14 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 460.0
SHD2_k127_3372192_15 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 457.0
SHD2_k127_3372192_16 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 441.0
SHD2_k127_3372192_17 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 432.0
SHD2_k127_3372192_18 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00042 - 1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 327.0
SHD2_k127_3372192_19 - K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008388 318.0
SHD2_k127_3372192_2 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 3.603e-238 745.0
SHD2_k127_3372192_20 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 301.0
SHD2_k127_3372192_21 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 298.0
SHD2_k127_3372192_22 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 296.0
SHD2_k127_3372192_23 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002117 280.0
SHD2_k127_3372192_24 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001458 279.0
SHD2_k127_3372192_25 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001141 266.0
SHD2_k127_3372192_26 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000003022 239.0
SHD2_k127_3372192_27 Short chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000184 231.0
SHD2_k127_3372192_28 multi-organism process K03195 - - 0.00000000000000000000000000000000000000000000000000000000003884 213.0
SHD2_k127_3372192_29 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000002738 205.0
SHD2_k127_3372192_3 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 2.431e-227 710.0
SHD2_k127_3372192_30 PFAM Appr-1-p processing - - - 0.00000000000000000000000000000000000000000000000000002741 197.0
SHD2_k127_3372192_31 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000005833 184.0
SHD2_k127_3372192_32 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000002404 164.0
SHD2_k127_3372192_33 cellular response to heat K09807 - - 0.000000000000000000000000000000000000000001594 166.0
SHD2_k127_3372192_34 sequence-specific DNA binding - - - 0.0000000000000000000000000000274 128.0
SHD2_k127_3372192_35 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000001273 103.0
SHD2_k127_3372192_36 chaperone-mediated protein folding - - - 0.0000000000000000000001099 101.0
SHD2_k127_3372192_37 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000006852 99.0
SHD2_k127_3372192_38 PFAM Magnesium chelatase, ChlI subunit K07391 - - 0.000000000000005388 78.0
SHD2_k127_3372192_39 - - - - 0.00000000001327 70.0
SHD2_k127_3372192_4 von Willebrand factor (vWF) type A domain K07114 - - 1.556e-208 654.0
SHD2_k127_3372192_40 Carboxypeptidase regulatory-like domain - - - 0.00000003321 63.0
SHD2_k127_3372192_5 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 9.307e-202 634.0
SHD2_k127_3372192_6 HD domain - - - 1.136e-199 626.0
SHD2_k127_3372192_7 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 601.0
SHD2_k127_3372192_8 Elongator protein 3, MiaB family, Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 593.0
SHD2_k127_3372192_9 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 595.0
SHD2_k127_3402777_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.378e-239 746.0
SHD2_k127_3402777_1 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 4.058e-194 614.0
SHD2_k127_3402777_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 524.0
SHD2_k127_3402777_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000002035 143.0
SHD2_k127_3402777_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000133 119.0
SHD2_k127_3402777_5 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000000000003634 97.0
SHD2_k127_353404_0 DNA polymerase K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 477.0
SHD2_k127_3566003_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1312.0
SHD2_k127_3566003_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 7.419e-304 946.0
SHD2_k127_3566003_10 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003517 253.0
SHD2_k127_3566003_11 4Fe-4S dicluster domain K05524 - - 0.0000000000000000000000000000000000000000000000001805 176.0
SHD2_k127_3566003_12 Thioredoxin-like - - - 0.000000000000000000000000000000000005604 142.0
SHD2_k127_3566003_13 Hfq protein K03666 - - 0.0000000000000000000000000000000002257 135.0
SHD2_k127_3566003_14 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.00000000000000000000000003061 108.0
SHD2_k127_3566003_15 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K16079 - - 0.0000000000000000000001184 104.0
SHD2_k127_3566003_2 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 1.229e-234 744.0
SHD2_k127_3566003_3 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 518.0
SHD2_k127_3566003_4 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 421.0
SHD2_k127_3566003_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 323.0
SHD2_k127_3566003_6 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 325.0
SHD2_k127_3566003_7 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 318.0
SHD2_k127_3566003_8 MoaE protein K21142 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000101 281.0
SHD2_k127_3566003_9 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005048 288.0
SHD2_k127_3667914_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1101.0
SHD2_k127_3667914_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 2.932e-319 999.0
SHD2_k127_3667914_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000003382 231.0
SHD2_k127_3667914_11 Glutathione peroxidase K02199 - - 0.0000000000000000000000000000000000000000000000000000000001554 209.0
SHD2_k127_3667914_12 DUF218 domain K03748 - - 0.000000000000000000000000000000000000000000000000000000002029 208.0
SHD2_k127_3667914_13 HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.00000000000000000000000000000000000000000000000000000000464 205.0
SHD2_k127_3667914_14 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000002161 197.0
SHD2_k127_3667914_15 PEGA domain - - - 0.00000000000000000000000000000000000000000000000000001681 196.0
SHD2_k127_3667914_16 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000001426 182.0
SHD2_k127_3667914_17 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000000000000000001734 175.0
SHD2_k127_3667914_18 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.000000000000000000000000000000000000002577 150.0
SHD2_k127_3667914_19 bacterial (prokaryotic) histone like domain K03530 - - 0.000000000000000000000000000000000000005198 147.0
SHD2_k127_3667914_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 3.837e-230 723.0
SHD2_k127_3667914_20 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000007446 151.0
SHD2_k127_3667914_21 Disulphide bond corrector protein DsbC - - - 0.000000000000000000000000000000000001875 143.0
SHD2_k127_3667914_22 Thioesterase - - - 0.0000000000000000005656 93.0
SHD2_k127_3667914_24 - - - - 0.000000000002113 72.0
SHD2_k127_3667914_26 Bacterial regulatory proteins, tetR family - - - 0.00000000003752 71.0
SHD2_k127_3667914_27 Galactose oxidase, central domain - - - 0.0000000002855 64.0
SHD2_k127_3667914_28 Tetratricopeptide repeat - - - 0.000000007106 60.0
SHD2_k127_3667914_3 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 522.0
SHD2_k127_3667914_30 Cytochrome c K00412 - - 0.0003457 48.0
SHD2_k127_3667914_4 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 476.0
SHD2_k127_3667914_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 346.0
SHD2_k127_3667914_6 Cytochrome C biogenesis protein K06196,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 325.0
SHD2_k127_3667914_8 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 297.0
SHD2_k127_3667914_9 Transcriptional regulator K07506 - - 0.00000000000000000000000000000000000000000000000000000000000005548 223.0
SHD2_k127_3805637_0 Beta-galactosidase - - - 1.828e-248 796.0
SHD2_k127_3805637_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 444.0
SHD2_k127_3805637_2 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 347.0
SHD2_k127_3805637_3 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 318.0
SHD2_k127_387394_0 GDSL-like Lipase/Acylhydrolase family - GO:0000272,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006080,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010383,GO:0010391,GO:0010410,GO:0016052,GO:0016787,GO:0016788,GO:0017144,GO:0042737,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0045491,GO:0045493,GO:0046555,GO:0052689,GO:0071554,GO:0071704,GO:1901575,GO:2000884 - 0.000000000000000000000000000000000000000000000000000000000000000000000002965 250.0
SHD2_k127_387394_1 Glycosyl hydrolases family 28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001674 249.0
SHD2_k127_3971941_0 Dipeptidyl carboxypeptidase K01284 - 3.4.15.5 5.225e-296 929.0
SHD2_k127_3971941_1 Aminotransferase class-V K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 604.0
SHD2_k127_3971941_2 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 450.0
SHD2_k127_3971941_3 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K00486 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0019748,GO:0044550,GO:0055114 1.14.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000001548 244.0
SHD2_k127_3971941_4 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007903 246.0
SHD2_k127_3971941_5 Universal stress protein - - - 0.00000000000000003564 85.0
SHD2_k127_3971941_6 - - - - 0.00000223 53.0
SHD2_k127_3991994_0 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000000000000000003777 195.0
SHD2_k127_3991994_1 PAS PAC sensor signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000003825 170.0
SHD2_k127_3991994_3 Tetratricopeptide repeat - - - 0.00001205 56.0
SHD2_k127_4039548_0 - - - - 0.000000000000000000000000000000000005823 139.0
SHD2_k127_4039548_1 hydroperoxide reductase activity K01607 - 4.1.1.44 0.000000000000000000000000000000001326 131.0
SHD2_k127_4039548_2 Phosphate acyltransferases K01897 - 6.2.1.3 0.000000000000000000007743 94.0
SHD2_k127_4108624_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0 1184.0
SHD2_k127_4108624_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0 1160.0
SHD2_k127_4108624_10 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 409.0
SHD2_k127_4108624_11 Major facilitator Superfamily K08152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 401.0
SHD2_k127_4108624_12 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 374.0
SHD2_k127_4108624_13 polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 368.0
SHD2_k127_4108624_14 ABC transporter K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008346 353.0
SHD2_k127_4108624_15 TIGRFAM TonB K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 340.0
SHD2_k127_4108624_16 efflux protein, MATE family K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000917 345.0
SHD2_k127_4108624_17 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 330.0
SHD2_k127_4108624_18 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009008 295.0
SHD2_k127_4108624_19 Thioredoxin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 296.0
SHD2_k127_4108624_2 PFAM Organic solvent tolerance protein K04744 - - 2.757e-251 801.0
SHD2_k127_4108624_20 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001301 283.0
SHD2_k127_4108624_21 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002073 286.0
SHD2_k127_4108624_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001368 271.0
SHD2_k127_4108624_23 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000429 261.0
SHD2_k127_4108624_24 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008982 256.0
SHD2_k127_4108624_25 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000005032 238.0
SHD2_k127_4108624_26 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.0000000000000000000000000000000000000000000000000000000000000001775 226.0
SHD2_k127_4108624_27 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.000000000000000000000000000000000000000000000000000000000001335 212.0
SHD2_k127_4108624_28 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000000000000000000000002419 212.0
SHD2_k127_4108624_29 Biotin-requiring enzyme - - - 0.0000000000000000000000000000000000000000000000000000000246 204.0
SHD2_k127_4108624_3 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.251e-248 775.0
SHD2_k127_4108624_30 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000000000000000000000000000000000005036 188.0
SHD2_k127_4108624_31 - - - - 0.000000000000000000000000000000000000000000000005449 175.0
SHD2_k127_4108624_32 Yip1 domain - - - 0.00000000000000000000000000000000000000000002952 171.0
SHD2_k127_4108624_33 endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000001591 162.0
SHD2_k127_4108624_34 Domain of unknown function (DUF1990) - - - 0.000000000000000000000000000000000000000002782 161.0
SHD2_k127_4108624_35 pfam rdd - - - 0.0000000000000000000000000000000003503 147.0
SHD2_k127_4108624_36 Domain of unknown function (DUF2383) - - - 0.0000000000000000000000000000000003743 136.0
SHD2_k127_4108624_37 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000000000000001112 116.0
SHD2_k127_4108624_38 GAF domain - - - 0.0000000000000000000006689 102.0
SHD2_k127_4108624_39 Sodium/hydrogen exchanger family - - - 0.000000000000000003513 86.0
SHD2_k127_4108624_4 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 2.084e-237 743.0
SHD2_k127_4108624_40 Domain of unknown function (DUF4349) - - - 0.00000000000000009104 91.0
SHD2_k127_4108624_41 SnoaL-like polyketide cyclase - - - 0.0000000000001598 76.0
SHD2_k127_4108624_43 - - - - 0.0000000546 55.0
SHD2_k127_4108624_5 Protein kinase domain K08884 - 2.7.11.1 1.89e-200 654.0
SHD2_k127_4108624_6 Adenosine/AMP deaminase K01488,K18286 - 3.5.4.4,3.5.4.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007221 452.0
SHD2_k127_4108624_7 PFAM Amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 439.0
SHD2_k127_4108624_8 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 417.0
SHD2_k127_4108624_9 MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005747 404.0
SHD2_k127_4213911_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005123 539.0
SHD2_k127_4213911_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 398.0
SHD2_k127_4213911_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000007136 227.0
SHD2_k127_4213911_3 Transcriptional regulator K07979 - - 0.00000000000000000000000000000000000000000000002105 174.0
SHD2_k127_4213911_4 BON domain K04065 - - 0.00000000000000000000000006664 116.0
SHD2_k127_4213911_5 - - - - 0.000000000000000000000000331 111.0
SHD2_k127_4213911_6 Heavy-metal resistance - - - 0.00000000000000000002011 100.0
SHD2_k127_4239031_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1016.0
SHD2_k127_4239031_1 TIGRFAM malto-oligosyltrehalose trehalohydrolase K01236 - 3.2.1.141 2.182e-223 708.0
SHD2_k127_4239031_2 glutathione-regulated potassium exporter activity K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009439 453.0
SHD2_k127_4239031_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000003925 213.0
SHD2_k127_4239031_4 TIGRFAM outer membrane protein assembly complex, YaeT protein K07277 - - 0.00000000000000000000000000000000000002911 145.0
SHD2_k127_4239031_5 TIGRFAM TonB K03832 - - 0.00000000000000000000000001442 121.0
SHD2_k127_4239031_6 Outer membrane protein (OmpH-like) K06142 - - 0.00000000000000000000004002 108.0
SHD2_k127_4239031_7 protein secretion K03116 - - 0.0000000000000000006596 87.0
SHD2_k127_4239031_8 Bacterial PH domain K08981 - - 0.0000000001882 69.0
SHD2_k127_4276544_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1331.0
SHD2_k127_4276544_1 Elongation factor G, domain IV K02355 - - 1e-323 999.0
SHD2_k127_4276544_10 Domain of unknown function (DUF4440) - - - 0.00000000000000001071 88.0
SHD2_k127_4276544_11 alkyl hydroperoxide reductase K03386,K03564 - 1.11.1.15 0.000000000001381 69.0
SHD2_k127_4276544_12 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000006706 66.0
SHD2_k127_4276544_13 anaphase-promoting complex binding - - - 0.0000002756 63.0
SHD2_k127_4276544_2 PFAM natural resistance-associated macrophage protein K03322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 603.0
SHD2_k127_4276544_3 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 604.0
SHD2_k127_4276544_4 peroxiredoxin activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 355.0
SHD2_k127_4276544_5 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000001973 253.0
SHD2_k127_4276544_6 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000002559 237.0
SHD2_k127_4276544_7 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000002174 190.0
SHD2_k127_4276544_8 peroxiredoxin activity K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000002782 160.0
SHD2_k127_4276544_9 catechol 1,2-dioxygenase - - - 0.000000000000000000084 97.0
SHD2_k127_4309055_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 3.697e-316 981.0
SHD2_k127_4309055_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 8.282e-243 755.0
SHD2_k127_4309055_10 outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 429.0
SHD2_k127_4309055_11 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 396.0
SHD2_k127_4309055_12 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 334.0
SHD2_k127_4309055_13 cytokinin biosynthetic process K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000003632 245.0
SHD2_k127_4309055_14 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006867 248.0
SHD2_k127_4309055_15 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000005946 201.0
SHD2_k127_4309055_16 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.000000000000000000000000000000000000000005234 159.0
SHD2_k127_4309055_17 phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000007139 90.0
SHD2_k127_4309055_18 CHAD - - - 0.0000000000000000329 92.0
SHD2_k127_4309055_2 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 3.989e-232 728.0
SHD2_k127_4309055_3 Tetratricopeptide repeats K12132 - 2.7.11.1 2.293e-225 723.0
SHD2_k127_4309055_4 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 8.753e-221 692.0
SHD2_k127_4309055_5 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 614.0
SHD2_k127_4309055_6 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 563.0
SHD2_k127_4309055_7 cAMP biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 556.0
SHD2_k127_4309055_8 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008688 524.0
SHD2_k127_4309055_9 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 466.0
SHD2_k127_4403468_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 296.0
SHD2_k127_4403468_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000003787 262.0
SHD2_k127_4403468_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004134 265.0
SHD2_k127_4403468_3 binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000000000000000000000003144 209.0
SHD2_k127_4403468_4 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000000000000006084 161.0
SHD2_k127_4403468_5 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000001222 157.0
SHD2_k127_4403468_6 - - - - 0.0000000000000000005013 95.0
SHD2_k127_4519282_0 Amino acid permease - - - 8.777e-314 977.0
SHD2_k127_4519282_1 Amino acid permease - - - 6.464e-300 938.0
SHD2_k127_4519282_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 4.162e-247 771.0
SHD2_k127_4519282_3 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 419.0
SHD2_k127_4519282_4 TIGRFAM Outer membrane assembly lipoprotein YfiO K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 362.0
SHD2_k127_4519282_5 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007273 335.0
SHD2_k127_4519282_6 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 315.0
SHD2_k127_4519282_7 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000005885 212.0
SHD2_k127_4519282_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000002479 150.0
SHD2_k127_4519282_9 translation initiation factor activity K06996 - - 0.0000000000000109 79.0
SHD2_k127_4519502_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1281.0
SHD2_k127_4519502_1 Permease, YjgP YjgQ - - - 0.0 1044.0
SHD2_k127_4519502_10 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 383.0
SHD2_k127_4519502_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 330.0
SHD2_k127_4519502_12 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006343 316.0
SHD2_k127_4519502_13 formate dehydrogenase (NAD+) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 288.0
SHD2_k127_4519502_14 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002253 245.0
SHD2_k127_4519502_15 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000008994 208.0
SHD2_k127_4519502_16 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000003343 162.0
SHD2_k127_4519502_17 Lipid A 3-O-deacylase (PagL) - - - 0.000000000000000000000000000000000000005305 154.0
SHD2_k127_4519502_18 - - - - 0.0000000000000000001662 98.0
SHD2_k127_4519502_19 Uncharacterized protein conserved in bacteria (DUF2059) K09924 - - 0.00000000000001231 82.0
SHD2_k127_4519502_2 Glycosyl hydrolase family 57 - - - 5.778e-288 902.0
SHD2_k127_4519502_20 Redoxin - - - 0.0000000000608 67.0
SHD2_k127_4519502_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 5.003e-262 816.0
SHD2_k127_4519502_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 4.091e-242 757.0
SHD2_k127_4519502_5 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.828e-224 700.0
SHD2_k127_4519502_6 PFAM Formiminotransferase domain K00603,K13990 - 2.1.2.5,4.3.1.4 8.823e-224 703.0
SHD2_k127_4519502_7 dna ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 522.0
SHD2_k127_4519502_8 PFAM Aminotransferase, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 465.0
SHD2_k127_4519502_9 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 436.0
SHD2_k127_4650975_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 1.275e-261 818.0
SHD2_k127_4650975_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 415.0
SHD2_k127_4669305_0 Protein involved in outer membrane biogenesis K07289 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 417.0
SHD2_k127_4669305_1 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001789 265.0
SHD2_k127_4709050_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1300.0
SHD2_k127_4709050_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1030.0
SHD2_k127_4709050_10 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006403 523.0
SHD2_k127_4709050_11 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 527.0
SHD2_k127_4709050_12 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 517.0
SHD2_k127_4709050_13 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 465.0
SHD2_k127_4709050_14 Domain of unknown function (DUF4010) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 431.0
SHD2_k127_4709050_15 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 418.0
SHD2_k127_4709050_16 chlorophyll binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 426.0
SHD2_k127_4709050_17 YVTN family beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007563 416.0
SHD2_k127_4709050_18 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 399.0
SHD2_k127_4709050_19 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 396.0
SHD2_k127_4709050_2 ATPase BadF BadG BcrA BcrD type - - - 3.008e-312 985.0
SHD2_k127_4709050_20 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 372.0
SHD2_k127_4709050_21 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 370.0
SHD2_k127_4709050_22 outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 355.0
SHD2_k127_4709050_23 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 350.0
SHD2_k127_4709050_24 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 327.0
SHD2_k127_4709050_25 response regulator, receiver K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 312.0
SHD2_k127_4709050_27 SMART cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001033 270.0
SHD2_k127_4709050_28 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008334 256.0
SHD2_k127_4709050_29 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000008648 227.0
SHD2_k127_4709050_3 transferase activity, transferring glycosyl groups - - - 2.763e-304 951.0
SHD2_k127_4709050_30 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000005479 221.0
SHD2_k127_4709050_31 thiolester hydrolase activity K07000 - - 0.000000000000000000000000000000000000000000000000694 198.0
SHD2_k127_4709050_32 Protein of unknown function (DUF3309) - - - 0.0000000000000003211 79.0
SHD2_k127_4709050_33 Involved in the tonB-independent uptake of proteins - - - 0.00000000000001403 87.0
SHD2_k127_4709050_34 PFAM Mov34 MPN PAD-1 - - - 0.000001084 56.0
SHD2_k127_4709050_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 3.308e-263 823.0
SHD2_k127_4709050_5 TIGRFAM ornithine aminotransferase K00819 - 2.6.1.13 5.283e-204 641.0
SHD2_k127_4709050_6 cyclic 2,3-diphosphoglycerate synthetase activity - - - 6.841e-199 629.0
SHD2_k127_4709050_7 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 591.0
SHD2_k127_4709050_8 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 587.0
SHD2_k127_4709050_9 lipoprotein localization to outer membrane K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 529.0
SHD2_k127_4748616_0 PFAM Type II secretion system protein E K02652 - - 2.572e-276 858.0
SHD2_k127_4748616_1 PFAM Type II secretion system F domain K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 520.0
SHD2_k127_4748616_10 outer membrane lipoprotein carrier protein LolA K03634 - - 0.0003133 43.0
SHD2_k127_4748616_2 COG0349 Ribonuclease D K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002142 287.0
SHD2_k127_4748616_3 Pilus assembly protein K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000512 250.0
SHD2_k127_4748616_4 - - - - 0.00000000000000000000000000000000000000000000000000001866 200.0
SHD2_k127_4748616_5 Belongs to the HesB IscA family - - - 0.00000000000000000000000000000000000000000000000000005923 188.0
SHD2_k127_4748616_6 Pilus assembly protein K02662 - - 0.0000000000000000000000000000000000006924 148.0
SHD2_k127_4748616_7 - - - - 0.00000000000000000000000000001582 124.0
SHD2_k127_4748616_8 - - - - 0.00000000000000000001282 93.0
SHD2_k127_4748616_9 - K02664 - - 0.0000000005824 68.0
SHD2_k127_474995_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.355e-219 694.0
SHD2_k127_474995_1 PAS domain - - - 3.161e-196 623.0
SHD2_k127_474995_11 - - - - 0.0004335 47.0
SHD2_k127_474995_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0005206 47.0
SHD2_k127_474995_2 MviN-like protein K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 611.0
SHD2_k127_474995_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 386.0
SHD2_k127_474995_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008523 349.0
SHD2_k127_474995_5 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009682 349.0
SHD2_k127_474995_6 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 313.0
SHD2_k127_474995_7 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000000003889 210.0
SHD2_k127_474995_8 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000000000000000000000000000000001286 207.0
SHD2_k127_474995_9 Histidine kinase K02482,K03557 - 2.7.13.3 0.0000000000000000000000000000000000000000000000002751 199.0
SHD2_k127_4826623_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1309.0
SHD2_k127_4826623_1 PFAM peptidase M61 - - - 1e-323 1003.0
SHD2_k127_4826623_10 MoeZ MoeB K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006879 532.0
SHD2_k127_4826623_11 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309,K11102 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 529.0
SHD2_k127_4826623_12 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 478.0
SHD2_k127_4826623_13 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 457.0
SHD2_k127_4826623_14 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 436.0
SHD2_k127_4826623_15 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 434.0
SHD2_k127_4826623_16 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 415.0
SHD2_k127_4826623_17 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 407.0
SHD2_k127_4826623_18 Phosphoesterase family K01114 - 3.1.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 394.0
SHD2_k127_4826623_19 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 372.0
SHD2_k127_4826623_2 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 2.11e-301 931.0
SHD2_k127_4826623_20 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 361.0
SHD2_k127_4826623_21 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 353.0
SHD2_k127_4826623_22 galactose-1-phosphate K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 362.0
SHD2_k127_4826623_23 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 345.0
SHD2_k127_4826623_24 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007202 342.0
SHD2_k127_4826623_25 TIGRFAM cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 312.0
SHD2_k127_4826623_26 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009476 295.0
SHD2_k127_4826623_27 Metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005449 284.0
SHD2_k127_4826623_28 Dihydrodipicolinate reductase, C-terminus K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001076 274.0
SHD2_k127_4826623_3 Ftsk_gamma K03466 - - 2.853e-294 923.0
SHD2_k127_4826623_30 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005432 264.0
SHD2_k127_4826623_31 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007921 250.0
SHD2_k127_4826623_32 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003138 237.0
SHD2_k127_4826623_33 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000001652 210.0
SHD2_k127_4826623_34 AntiSigma factor - - - 0.0000000000000000000000000000000000000000000000000000001044 205.0
SHD2_k127_4826623_35 PFAM Cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000006051 195.0
SHD2_k127_4826623_37 - - - - 0.00000000000000000000000000000000000000000000000000004373 201.0
SHD2_k127_4826623_38 PFAM Peptidase family M20 M25 M40 K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000008904 199.0
SHD2_k127_4826623_39 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.0000000000000000000000000000000000000000000002794 173.0
SHD2_k127_4826623_4 surface antigen variable number - - - 1.908e-293 934.0
SHD2_k127_4826623_40 Transcriptional regulator PadR-like family K10947 - - 0.0000000000000000000000000000000000000000000832 164.0
SHD2_k127_4826623_41 PepSY-associated TM region - - - 0.000000000000000000000000000000000000000001336 170.0
SHD2_k127_4826623_42 - - - - 0.00000000000000000000000000000000000000001714 168.0
SHD2_k127_4826623_43 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000003991 162.0
SHD2_k127_4826623_44 Predicted membrane protein (DUF2306) - - - 0.00000000000000000000000000000000000004469 151.0
SHD2_k127_4826623_45 YjbR - - - 0.0000000000000000000000000000000000001627 149.0
SHD2_k127_4826623_46 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000002097 147.0
SHD2_k127_4826623_47 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.00000000000000000000000000000000004001 143.0
SHD2_k127_4826623_49 Response regulator, receiver - - - 0.0000000000000000000000000001256 124.0
SHD2_k127_4826623_5 TamB, inner membrane protein subunit of TAM complex K09800 - - 8.901e-284 919.0
SHD2_k127_4826623_50 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.0000000000000000000000000007735 117.0
SHD2_k127_4826623_51 Cupin domain - - - 0.000000000000000000000000006128 113.0
SHD2_k127_4826623_52 EamA-like transporter family - - - 0.0000000000000000000000000456 119.0
SHD2_k127_4826623_53 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000004834 109.0
SHD2_k127_4826623_54 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.000000000000000000001633 98.0
SHD2_k127_4826623_55 Crp Fnr family K21564 - - 0.0000000000000000002798 97.0
SHD2_k127_4826623_56 Sel1-like repeats. K07126 - - 0.00000000000000007167 85.0
SHD2_k127_4826623_57 - - - - 0.0000000000000002234 88.0
SHD2_k127_4826623_58 - - - - 0.000000000000002824 77.0
SHD2_k127_4826623_6 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.045e-255 790.0
SHD2_k127_4826623_60 Universal stress protein - - - 0.00000000003638 74.0
SHD2_k127_4826623_61 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.000000003631 67.0
SHD2_k127_4826623_62 - - - - 0.000000003965 63.0
SHD2_k127_4826623_63 - - - - 0.00000009815 62.0
SHD2_k127_4826623_64 PFAM beta-lactamase - - - 0.0006667 44.0
SHD2_k127_4826623_7 Belongs to the aspartokinase family K00928 - 2.7.2.4 2.406e-196 621.0
SHD2_k127_4826623_8 Aspartate-ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 599.0
SHD2_k127_4826623_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 567.0
SHD2_k127_4827270_0 Protein of unknown function (DUF763) K09003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 565.0
SHD2_k127_4827270_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 496.0
SHD2_k127_4827270_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 449.0
SHD2_k127_4827270_3 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 376.0
SHD2_k127_4827270_4 FR47-like protein - - - 0.00000000000000000000000000000000000000000000000000001092 197.0
SHD2_k127_4827270_5 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000000000000001026 132.0
SHD2_k127_4827270_6 membrane - - - 0.00000000000000000000000007625 113.0
SHD2_k127_4827270_7 PFAM Hemerythrin HHE cation binding domain protein K07216 - - 0.000000000000000000002101 98.0
SHD2_k127_4827270_8 PFAM Phosphoglycerate mutase - - - 0.000000000000000001785 91.0
SHD2_k127_4845256_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 511.0
SHD2_k127_4845256_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 312.0
SHD2_k127_4845256_2 Iodothyronine deiodinase - - - 0.00000000000000000000000000000000000687 140.0
SHD2_k127_4845256_3 - - - - 0.00000000000000000000000000005334 119.0
SHD2_k127_4845256_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03665 - - 0.000002145 53.0
SHD2_k127_4845256_5 Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c - - - 0.0002215 51.0
SHD2_k127_4845387_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1057.0
SHD2_k127_4845387_1 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 - 1.1.1.42 5.441e-251 782.0
SHD2_k127_4845387_10 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 286.0
SHD2_k127_4845387_11 SMART cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001948 259.0
SHD2_k127_4845387_12 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002985 256.0
SHD2_k127_4845387_13 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001303 256.0
SHD2_k127_4845387_14 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000008683 232.0
SHD2_k127_4845387_15 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000000000000000001632 181.0
SHD2_k127_4845387_16 - - - - 0.000000000000000000000000000000000000000000008775 172.0
SHD2_k127_4845387_17 Response regulator, receiver - - - 0.0000000000000000000000000000000000001931 150.0
SHD2_k127_4845387_18 Starch binding domain K01200 - 3.2.1.41 0.0000000000000000000000000000000002322 144.0
SHD2_k127_4845387_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 7.138e-222 694.0
SHD2_k127_4845387_20 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000252 122.0
SHD2_k127_4845387_21 - - - - 0.0000000000000000000000000001717 118.0
SHD2_k127_4845387_22 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.000000000000000000000000000601 117.0
SHD2_k127_4845387_23 - - - - 0.00000000004052 71.0
SHD2_k127_4845387_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 534.0
SHD2_k127_4845387_4 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 519.0
SHD2_k127_4845387_5 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009993 490.0
SHD2_k127_4845387_6 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005692 443.0
SHD2_k127_4845387_7 PFAM Peptidase M19, renal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 430.0
SHD2_k127_4845387_8 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 292.0
SHD2_k127_4845387_9 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007432 287.0
SHD2_k127_4858680_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 6.009e-273 850.0
SHD2_k127_4858680_1 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 0.0000000000000000000000000000000000000000000000000000000001652 210.0
SHD2_k127_4858680_2 - - - - 0.0000000000000000000000000006956 118.0
SHD2_k127_4859475_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 5.34e-291 905.0
SHD2_k127_4859475_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.017e-254 793.0
SHD2_k127_4859475_2 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 551.0
SHD2_k127_4859475_3 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 472.0
SHD2_k127_4859475_4 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 368.0
SHD2_k127_4859475_5 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 333.0
SHD2_k127_4859475_6 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 329.0
SHD2_k127_4859475_7 - - - - 0.0000000000000000000000000000000000000000000000000000002676 211.0
SHD2_k127_4859475_8 Disulphide isomerase - - - 0.000000000000000000000000000000000000000000000001286 177.0
SHD2_k127_4859475_9 Rhomboid K19225 - 3.4.21.105 0.000000000000000000000000000000000000000000000147 185.0
SHD2_k127_4883490_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1387.0
SHD2_k127_4883490_1 radical SAM domain protein K22318 - - 7.649e-251 783.0
SHD2_k127_4883490_2 PFAM Glycosyl transferase family 2 - - - 7.966e-196 618.0
SHD2_k127_4883490_3 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005838 602.0
SHD2_k127_4883490_4 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 296.0
SHD2_k127_4883490_5 DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003829 269.0
SHD2_k127_4883490_6 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000001532 219.0
SHD2_k127_4883490_7 PFAM S23 ribosomal protein - - - 0.0000000000000000000000000007448 117.0
SHD2_k127_4883490_8 Helix-hairpin-helix motif - - - 0.00000000000000000003778 96.0
SHD2_k127_4979789_0 Glycosyl hydrolase 38 domain protein K01191 - 3.2.1.24 4.877e-306 972.0
SHD2_k127_4979789_1 Lactonase, 7-bladed beta-propeller - - - 2.248e-285 906.0
SHD2_k127_4979789_10 pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000008198 236.0
SHD2_k127_4979789_11 Belongs to the uridine kinase family K00876 - 2.7.1.48 0.00000000000000000000000000000000000000000000000000001526 194.0
SHD2_k127_4979789_12 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000000000000009151 138.0
SHD2_k127_4979789_13 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000007467 102.0
SHD2_k127_4979789_2 Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 602.0
SHD2_k127_4979789_3 PFAM Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007918 547.0
SHD2_k127_4979789_4 PFAM Adenosine AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 496.0
SHD2_k127_4979789_5 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 459.0
SHD2_k127_4979789_6 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 367.0
SHD2_k127_4979789_7 S1/P1 Nuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 294.0
SHD2_k127_4979789_8 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000001747 269.0
SHD2_k127_4979789_9 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000005727 252.0
SHD2_k127_499567_0 Radical SAM K06937 - - 3.866e-247 773.0
SHD2_k127_499567_1 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 2.345e-243 773.0
SHD2_k127_499567_10 Redoxin - - - 0.00000000000000000000000000000000000002063 149.0
SHD2_k127_499567_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000002613 146.0
SHD2_k127_499567_12 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000000000000000137 128.0
SHD2_k127_499567_13 - - - - 0.000000000000000000000000001578 118.0
SHD2_k127_499567_16 CsbD-like - - - 0.000000000000003285 78.0
SHD2_k127_499567_17 - - - - 0.00000000000002103 81.0
SHD2_k127_499567_18 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.000000000004975 75.0
SHD2_k127_499567_19 Zinc-dependent metalloprotease - - - 0.0000000004682 72.0
SHD2_k127_499567_2 PA domain - - - 1.128e-197 631.0
SHD2_k127_499567_20 Phage tail tube, TTP, lambda-like - - - 0.000000006379 70.0
SHD2_k127_499567_21 pilus assembly protein PilW K02672 - - 0.0005888 50.0
SHD2_k127_499567_3 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 527.0
SHD2_k127_499567_4 FES K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 329.0
SHD2_k127_499567_5 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008654 304.0
SHD2_k127_499567_6 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000002702 256.0
SHD2_k127_499567_7 Protein of unknown function, DUF481 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002765 242.0
SHD2_k127_499567_8 Protein of unknown function, DUF481 - - - 0.000000000000000000000000000000000000000000000000000000000000001825 230.0
SHD2_k127_499567_9 - - - - 0.00000000000000000000000000000000000000000000004111 179.0
SHD2_k127_5025928_0 Belongs to the glycosyl hydrolase 57 family - - - 1.88e-315 987.0
SHD2_k127_5025928_1 Malate synthase K01638 - 2.3.3.9 2.787e-248 779.0
SHD2_k127_5025928_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 592.0
SHD2_k127_5025928_11 excinuclease ABC activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 505.0
SHD2_k127_5025928_12 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 404.0
SHD2_k127_5025928_13 IstB-like ATP binding protein K02315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 348.0
SHD2_k127_5025928_14 cyclic nucleotide-binding K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007042 334.0
SHD2_k127_5025928_15 ATPases associated with a variety of cellular activities K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 303.0
SHD2_k127_5025928_16 ABC-type glycine betaine transport system K05845 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 304.0
SHD2_k127_5025928_17 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000003622 242.0
SHD2_k127_5025928_18 PFAM Binding-protein-dependent transport system inner membrane component K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000001356 230.0
SHD2_k127_5025928_19 R3H domain K06346 - - 0.00000000000000000000000000000000000000000000000000000004204 201.0
SHD2_k127_5025928_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 1.518e-227 713.0
SHD2_k127_5025928_20 - - - - 0.0000000000000000000000000000000000000000000000000002106 190.0
SHD2_k127_5025928_21 - - - - 0.000000000000000000000000000000000000000004011 160.0
SHD2_k127_5025928_22 RNA recognition motif - - - 0.0000000000000000000000000001738 123.0
SHD2_k127_5025928_23 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000001365 111.0
SHD2_k127_5025928_24 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000000000000002831 112.0
SHD2_k127_5025928_25 - - - - 0.000000000000000000000001551 112.0
SHD2_k127_5025928_26 - - - - 0.00000000000000000000001062 103.0
SHD2_k127_5025928_28 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000000000004122 87.0
SHD2_k127_5025928_29 - - - - 0.0000000000009558 73.0
SHD2_k127_5025928_3 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 5.585e-220 689.0
SHD2_k127_5025928_31 Prokaryotic N-terminal methylation motif K02456,K02655 - - 0.0000008074 57.0
SHD2_k127_5025928_4 Belongs to the glycosyl hydrolase 2 family K01195 - 3.2.1.31 4.529e-218 692.0
SHD2_k127_5025928_5 RNA binding K06959 - - 2.365e-206 649.0
SHD2_k127_5025928_6 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 1.631e-202 639.0
SHD2_k127_5025928_7 Isocitrate lyase family K01637 - 4.1.3.1 1.86e-202 639.0
SHD2_k127_5025928_8 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.599e-198 634.0
SHD2_k127_5025928_9 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 600.0
SHD2_k127_5036818_0 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002827 283.0
SHD2_k127_5036818_1 Phosphate acyltransferases K00655,K01897 - 2.3.1.51,6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000006631 257.0
SHD2_k127_511981_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006863 257.0
SHD2_k127_511981_1 phosphatidate phosphatase activity K19302 - 3.6.1.27 0.00000000000000000000000000000000002747 143.0
SHD2_k127_511981_2 Glycosyl transferase family 1 - - - 0.0000000000000000357 82.0
SHD2_k127_5325634_0 PFAM FAD dependent oxidoreductase K03153 - 1.4.3.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 323.0
SHD2_k127_5325634_1 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 316.0
SHD2_k127_5325634_3 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000001786 172.0
SHD2_k127_5325634_4 - - - - 0.0000000000000000000000000000000000003205 148.0
SHD2_k127_5325634_5 Sortase family K07284 - 3.4.22.70 0.000000001176 61.0
SHD2_k127_5328733_0 TonB-dependent receptor K13735,K20276 - - 1.943e-314 1000.0
SHD2_k127_5328733_1 cAMP biosynthetic process K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 485.0
SHD2_k127_5328733_2 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 441.0
SHD2_k127_5328733_3 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 362.0
SHD2_k127_5328733_4 coenzyme F420 hydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009238 331.0
SHD2_k127_5328733_5 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000219 288.0
SHD2_k127_5328733_6 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002453 235.0
SHD2_k127_5328733_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000007662 193.0
SHD2_k127_5328733_8 - - - - 0.0000000000000000004015 95.0
SHD2_k127_5355240_0 Heat shock 70 kDa protein K04043 - - 2.923e-298 923.0
SHD2_k127_5355240_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000005357 199.0
SHD2_k127_5374955_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 3.335e-271 843.0
SHD2_k127_5374955_1 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 509.0
SHD2_k127_5374955_2 Pfam Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 440.0
SHD2_k127_5374955_3 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005545 349.0
SHD2_k127_5374955_4 Hydrogenase maturation protease K03605 - - 0.00000000000000000000000000000000000004393 150.0
SHD2_k127_5387603_0 TIGRFAM carbamoyl-phosphate synthase, large subunit K01955 - 6.3.5.5 0.0 1652.0
SHD2_k127_5387603_1 Histidine kinase K02482 - 2.7.13.3 6.923e-312 998.0
SHD2_k127_5387603_10 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007253 418.0
SHD2_k127_5387603_11 Chemotaxis protein CheA K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 407.0
SHD2_k127_5387603_12 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 391.0
SHD2_k127_5387603_13 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 381.0
SHD2_k127_5387603_14 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 371.0
SHD2_k127_5387603_15 Ku70/Ku80 beta-barrel domain K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008866 366.0
SHD2_k127_5387603_16 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K02660,K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 333.0
SHD2_k127_5387603_17 Protein of unknown function (DUF4256) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008345 317.0
SHD2_k127_5387603_18 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001942 285.0
SHD2_k127_5387603_19 protein-glutamate methylesterase activity K03412,K03413 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002792 266.0
SHD2_k127_5387603_2 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 1.317e-231 734.0
SHD2_k127_5387603_20 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000008455 236.0
SHD2_k127_5387603_21 Chemotaxis phosphatase CheX K03409 - - 0.000000000000000000000000000000000000000000000000000000000000000009171 229.0
SHD2_k127_5387603_22 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000000000000000000000000004345 211.0
SHD2_k127_5387603_23 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000006107 199.0
SHD2_k127_5387603_24 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000001707 181.0
SHD2_k127_5387603_25 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000002358 169.0
SHD2_k127_5387603_26 - - - - 0.00000000000000000000000000000000000000000352 164.0
SHD2_k127_5387603_27 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000007998 158.0
SHD2_k127_5387603_28 Response regulator, receiver - - - 0.00000000000000000000000000000000000004944 149.0
SHD2_k127_5387603_29 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000149 154.0
SHD2_k127_5387603_3 TIGRFAM Carbamoyl-phosphate synthase, small subunit K01956 - 6.3.5.5 4.313e-208 650.0
SHD2_k127_5387603_30 cheY-homologous receiver domain K02658 - - 0.00000000000000000000000000000000002762 139.0
SHD2_k127_5387603_31 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000000009725 145.0
SHD2_k127_5387603_32 amine dehydrogenase activity - - - 0.000000000000000000000000000000002367 145.0
SHD2_k127_5387603_34 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000000000003341 97.0
SHD2_k127_5387603_35 Domain of unknown function (DUF4440) - - - 0.000000000000000000007292 102.0
SHD2_k127_5387603_36 nuclear chromosome segregation K02666,K03497,K19622 - - 0.000000000000000000008134 102.0
SHD2_k127_5387603_37 chemotaxis signal transduction protein K03408 - - 0.0000000000000004283 85.0
SHD2_k127_5387603_38 Two component signalling adaptor domain K03408 - - 0.000001527 59.0
SHD2_k127_5387603_39 Response regulator receiver domain K07658 - - 0.00000375 57.0
SHD2_k127_5387603_4 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 564.0
SHD2_k127_5387603_40 TPR repeat - - - 0.00007118 54.0
SHD2_k127_5387603_5 Signal transducing histidine kinase, homodimeric domain K02487,K03407,K06596 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 528.0
SHD2_k127_5387603_6 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 499.0
SHD2_k127_5387603_7 CheR methyltransferase, all-alpha domain K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 484.0
SHD2_k127_5387603_8 Bacterial regulatory protein, Fis family K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 434.0
SHD2_k127_5387603_9 Required for morphogenesis under gluconeogenic growth conditions - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 415.0
SHD2_k127_5425385_0 ABC transporter transmembrane region K11085 - - 6.619e-259 811.0
SHD2_k127_5425385_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 569.0
SHD2_k127_5425385_2 Belongs to the glycosyl hydrolase 30 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 496.0
SHD2_k127_5425385_3 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 359.0
SHD2_k127_5425385_4 PLD-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007318 331.0
SHD2_k127_5425385_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 291.0
SHD2_k127_5425385_6 phosphatidate phosphatase activity K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000004288 215.0
SHD2_k127_5425385_7 TIGRFAM Carbohydrate kinase, thermoresistant glucokinase K00851 - 2.7.1.12 0.00000000000000000000000000000000000000000000000000008295 190.0
SHD2_k127_5425385_8 - - - - 0.0000000000000000000009293 102.0
SHD2_k127_5425385_9 CHASE3 domain - - - 0.0000000000006261 70.0
SHD2_k127_5438239_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1662.0
SHD2_k127_5438239_1 Bacterial protein of unknown function (DUF885) - - - 4.319e-217 687.0
SHD2_k127_5438239_10 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 466.0
SHD2_k127_5438239_11 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 450.0
SHD2_k127_5438239_12 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 445.0
SHD2_k127_5438239_13 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 437.0
SHD2_k127_5438239_14 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 413.0
SHD2_k127_5438239_15 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 410.0
SHD2_k127_5438239_16 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 373.0
SHD2_k127_5438239_17 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 326.0
SHD2_k127_5438239_18 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006961 319.0
SHD2_k127_5438239_19 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009051 304.0
SHD2_k127_5438239_2 PFAM Aminotransferase class-III K01845 - 5.4.3.8 8.528e-217 679.0
SHD2_k127_5438239_20 PFAM glycosyl transferase family 9 K02841 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 293.0
SHD2_k127_5438239_21 Transposase (IS116 IS110 IS902 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007124 296.0
SHD2_k127_5438239_22 polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002003 277.0
SHD2_k127_5438239_23 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000002381 269.0
SHD2_k127_5438239_24 outer membrane autotransporter barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007243 250.0
SHD2_k127_5438239_25 Bifunctional protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000007388 243.0
SHD2_k127_5438239_26 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000005198 235.0
SHD2_k127_5438239_27 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000007077 216.0
SHD2_k127_5438239_28 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000007047 202.0
SHD2_k127_5438239_29 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000158 181.0
SHD2_k127_5438239_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.503e-213 672.0
SHD2_k127_5438239_30 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000003795 171.0
SHD2_k127_5438239_31 - - - - 0.00000000000000000000000000000000000000000008659 168.0
SHD2_k127_5438239_32 hyperosmotic response - - - 0.000000000000000000000000000000000000000006588 160.0
SHD2_k127_5438239_33 OsmC-like protein - - - 0.00000000000000000000000000000000000000001554 157.0
SHD2_k127_5438239_34 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000004518 139.0
SHD2_k127_5438239_35 YCII-related domain K09780 - - 0.00000000000000000000000000004167 126.0
SHD2_k127_5438239_36 - - - - 0.000000000000000000000002437 108.0
SHD2_k127_5438239_37 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000005592 102.0
SHD2_k127_5438239_39 - - - - 0.0000000000000000001681 102.0
SHD2_k127_5438239_4 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 626.0
SHD2_k127_5438239_41 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000001523 69.0
SHD2_k127_5438239_5 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000924 591.0
SHD2_k127_5438239_6 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 582.0
SHD2_k127_5438239_7 Belongs to the OprB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 552.0
SHD2_k127_5438239_8 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 506.0
SHD2_k127_5438239_9 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 465.0
SHD2_k127_5461373_0 Hsp90 protein K04079 - - 5.571e-234 730.0
SHD2_k127_5461373_1 Protein of unknown function (DUF2971) - - - 0.000002501 53.0
SHD2_k127_5507564_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1463.0
SHD2_k127_5507564_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1006.0
SHD2_k127_5507564_10 carboxylic acid catabolic process K19802 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 493.0
SHD2_k127_5507564_11 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 452.0
SHD2_k127_5507564_12 Phosphate acyltransferases K05939 - 2.3.1.40,6.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 441.0
SHD2_k127_5507564_13 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 404.0
SHD2_k127_5507564_14 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 409.0
SHD2_k127_5507564_15 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 422.0
SHD2_k127_5507564_16 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 385.0
SHD2_k127_5507564_17 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 373.0
SHD2_k127_5507564_18 Transcriptional regulator, LysR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 366.0
SHD2_k127_5507564_19 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 360.0
SHD2_k127_5507564_2 Glycosyl hydrolases family 2 K15855 - 3.2.1.165 1.626e-270 859.0
SHD2_k127_5507564_20 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016020,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 371.0
SHD2_k127_5507564_21 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 347.0
SHD2_k127_5507564_22 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 329.0
SHD2_k127_5507564_23 NlpC/P60 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 327.0
SHD2_k127_5507564_24 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 320.0
SHD2_k127_5507564_25 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 312.0
SHD2_k127_5507564_26 Transcriptional regulator, DeoR K02081 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 308.0
SHD2_k127_5507564_27 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 299.0
SHD2_k127_5507564_28 Molybdate ABC transporter K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 295.0
SHD2_k127_5507564_29 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 298.0
SHD2_k127_5507564_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 3.059e-219 688.0
SHD2_k127_5507564_30 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 304.0
SHD2_k127_5507564_31 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006439 278.0
SHD2_k127_5507564_32 TOBE domain K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000001057 276.0
SHD2_k127_5507564_33 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001058 268.0
SHD2_k127_5507564_34 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000005636 259.0
SHD2_k127_5507564_35 Protein of unknown function (DUF1349) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002641 279.0
SHD2_k127_5507564_36 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000806 239.0
SHD2_k127_5507564_37 AntiSigma factor - - - 0.0000000000000000000000000000000000000000000000000000000000000003808 227.0
SHD2_k127_5507564_38 hemolysin iii K11068 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000001507 214.0
SHD2_k127_5507564_39 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0000000000000000000000000000000000000000000000000000000004508 205.0
SHD2_k127_5507564_4 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 596.0
SHD2_k127_5507564_40 Molybdate ABC transporter substrate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000005733 209.0
SHD2_k127_5507564_41 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000009073 199.0
SHD2_k127_5507564_42 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000001831 179.0
SHD2_k127_5507564_43 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000003711 170.0
SHD2_k127_5507564_44 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000004775 157.0
SHD2_k127_5507564_45 - - - - 0.00000000000000000000000000000000001426 143.0
SHD2_k127_5507564_46 Pfam:N_methyl_2 - - - 0.0000000000000000000000000000000006096 136.0
SHD2_k127_5507564_48 - - - - 0.00000000000000000000000000004038 126.0
SHD2_k127_5507564_49 Tetratricopeptide repeat - - - 0.00000000000000000000000006279 121.0
SHD2_k127_5507564_5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 567.0
SHD2_k127_5507564_50 Platelet-activating factor acetylhydrolase, plasma intracellular isoform II - - - 0.00000000000000000000008294 110.0
SHD2_k127_5507564_51 - - - - 0.0000000000000000000006281 102.0
SHD2_k127_5507564_52 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000008007 102.0
SHD2_k127_5507564_53 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000000107 75.0
SHD2_k127_5507564_54 - - - - 0.00000002687 58.0
SHD2_k127_5507564_55 deoxyhypusine monooxygenase activity - - - 0.0000001911 64.0
SHD2_k127_5507564_56 SMART Tetratricopeptide - - - 0.000003121 61.0
SHD2_k127_5507564_6 PFAM Major facilitator superfamily K08178 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 535.0
SHD2_k127_5507564_7 AsmA family K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004845 552.0
SHD2_k127_5507564_8 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 525.0
SHD2_k127_5507564_9 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 513.0
SHD2_k127_550940_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 2.75e-321 1002.0
SHD2_k127_550940_1 Belongs to the aldehyde dehydrogenase family K00130,K00135,K00146,K22187 - 1.2.1.16,1.2.1.20,1.2.1.39,1.2.1.79,1.2.1.8 9.027e-257 799.0
SHD2_k127_550940_10 Methyltransferase K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000009118 216.0
SHD2_k127_550940_11 PFAM Redoxin - - - 0.0000000000000000000000000000000000000000000000000001804 190.0
SHD2_k127_550940_12 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000001122 187.0
SHD2_k127_550940_13 DinB family - - - 0.000000000000000000000000000000000000000000000000003453 194.0
SHD2_k127_550940_14 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000002022 179.0
SHD2_k127_550940_15 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000000000000000000000963 128.0
SHD2_k127_550940_16 - - - - 0.000000000000000000000001878 108.0
SHD2_k127_550940_2 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 351.0
SHD2_k127_550940_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 340.0
SHD2_k127_550940_4 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 330.0
SHD2_k127_550940_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 332.0
SHD2_k127_550940_6 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000708 302.0
SHD2_k127_550940_7 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004223 273.0
SHD2_k127_550940_8 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001422 268.0
SHD2_k127_550940_9 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000005622 218.0
SHD2_k127_5547375_0 Glycosyl transferase, family 2 - - - 0.0 1550.0
SHD2_k127_5547375_1 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0 1108.0
SHD2_k127_5547375_10 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.42e-212 665.0
SHD2_k127_5547375_11 IgA Peptidase M64 - - - 8.695e-195 618.0
SHD2_k127_5547375_12 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 549.0
SHD2_k127_5547375_13 HI0933 family K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 527.0
SHD2_k127_5547375_14 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 528.0
SHD2_k127_5547375_15 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 519.0
SHD2_k127_5547375_16 ABC-type multidrug transport system ATPase and permease K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007458 520.0
SHD2_k127_5547375_17 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 480.0
SHD2_k127_5547375_18 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 472.0
SHD2_k127_5547375_19 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 436.0
SHD2_k127_5547375_2 Belongs to the transketolase family K00615 - 2.2.1.1 9.767e-315 975.0
SHD2_k127_5547375_20 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 404.0
SHD2_k127_5547375_21 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 391.0
SHD2_k127_5547375_22 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 372.0
SHD2_k127_5547375_23 Conserved hypothetical protein 698 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 365.0
SHD2_k127_5547375_24 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 357.0
SHD2_k127_5547375_25 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008032 359.0
SHD2_k127_5547375_26 ethanolamine kinase activity K07251 - 2.7.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 367.0
SHD2_k127_5547375_27 copper resistance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 338.0
SHD2_k127_5547375_28 COG2706 3-carboxymuconate cyclase K07404 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 327.0
SHD2_k127_5547375_29 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 312.0
SHD2_k127_5547375_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 9.961e-281 868.0
SHD2_k127_5547375_30 Sh3 type 3 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 316.0
SHD2_k127_5547375_31 Aldose 1-epimerase K01792 - 5.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 307.0
SHD2_k127_5547375_32 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002409 281.0
SHD2_k127_5547375_33 Protein phosphatase 2C K01090,K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008641 276.0
SHD2_k127_5547375_34 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005254 256.0
SHD2_k127_5547375_35 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000002232 254.0
SHD2_k127_5547375_36 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008434 270.0
SHD2_k127_5547375_37 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000000000001544 253.0
SHD2_k127_5547375_38 Sucrose-6F-phosphate phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002183 248.0
SHD2_k127_5547375_39 PFAM tRNA rRNA methyltransferase, SpoU K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000001687 243.0
SHD2_k127_5547375_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 7.95e-278 857.0
SHD2_k127_5547375_40 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000004375 219.0
SHD2_k127_5547375_41 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000887 218.0
SHD2_k127_5547375_42 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000001482 219.0
SHD2_k127_5547375_43 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000004668 215.0
SHD2_k127_5547375_44 peroxiredoxin activity K01607,K03469 - 3.1.26.4,4.1.1.44 0.00000000000000000000000000000000000000000000000000000000000008375 214.0
SHD2_k127_5547375_45 - - - - 0.00000000000000000000000000000000000000000000000000000000001022 211.0
SHD2_k127_5547375_46 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000139 212.0
SHD2_k127_5547375_47 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000003679 201.0
SHD2_k127_5547375_48 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000845 199.0
SHD2_k127_5547375_49 - - - - 0.000000000000000000000000000000000000000000000001009 180.0
SHD2_k127_5547375_5 Delta-1-pyrroline-5-carboxylate dehydrogenase K00294 - 1.2.1.88 4.57e-249 780.0
SHD2_k127_5547375_50 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000002112 176.0
SHD2_k127_5547375_51 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000003703 180.0
SHD2_k127_5547375_52 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000003937 173.0
SHD2_k127_5547375_53 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000003131 161.0
SHD2_k127_5547375_54 Belongs to the ATPase B chain family K02109 - - 0.0000000000000000000000000000000001554 137.0
SHD2_k127_5547375_55 RNA recognition motif - - - 0.000000000000000000000000000000003518 130.0
SHD2_k127_5547375_56 - - - - 0.00000000000000000000000000000001048 130.0
SHD2_k127_5547375_57 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000001775 130.0
SHD2_k127_5547375_58 - - - - 0.00000000000000000000000000000002434 130.0
SHD2_k127_5547375_59 Vitamin K epoxide reductase - - - 0.000000000000000000000000000005335 123.0
SHD2_k127_5547375_6 PFAM TonB-dependent Receptor Plug - - - 2.706e-244 794.0
SHD2_k127_5547375_60 RibD C-terminal domain - - - 0.00000000000000000000000000008907 124.0
SHD2_k127_5547375_61 Cytochrome c - - - 0.0000000000000000000000000001437 121.0
SHD2_k127_5547375_62 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000002436 122.0
SHD2_k127_5547375_63 PilZ domain - - - 0.000000000000000000000000009198 112.0
SHD2_k127_5547375_64 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K16079 - - 0.00000000000000000000000003384 116.0
SHD2_k127_5547375_66 Chemotaxis phosphatase CheX - - - 0.0000000000000000000000371 104.0
SHD2_k127_5547375_67 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000001508 104.0
SHD2_k127_5547375_68 Zincin-like metallopeptidase - - - 0.0000000000000000000002158 100.0
SHD2_k127_5547375_7 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 3.716e-237 743.0
SHD2_k127_5547375_70 (FHA) domain - - - 0.000000000000000001708 94.0
SHD2_k127_5547375_71 DNA-binding transcription factor activity - - - 0.00000000000000008 89.0
SHD2_k127_5547375_72 - - - - 0.00000000000002106 78.0
SHD2_k127_5547375_74 Putative zinc-finger - - - 0.000000000006308 70.0
SHD2_k127_5547375_76 - - - - 0.0000004287 56.0
SHD2_k127_5547375_8 PFAM TonB-dependent Receptor Plug - - - 2.145e-230 751.0
SHD2_k127_5547375_9 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 4.089e-226 708.0
SHD2_k127_5618728_0 Alpha amylase - - - 0.0 1459.0
SHD2_k127_5618728_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1272.0
SHD2_k127_5618728_10 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009312 591.0
SHD2_k127_5618728_11 Belongs to the aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 577.0
SHD2_k127_5618728_12 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K01635 - 4.1.2.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 550.0
SHD2_k127_5618728_13 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 544.0
SHD2_k127_5618728_14 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 535.0
SHD2_k127_5618728_15 ATP dependent DNA ligase C terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 512.0
SHD2_k127_5618728_16 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007655 499.0
SHD2_k127_5618728_17 Selenocysteine lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 501.0
SHD2_k127_5618728_18 Saccharopine dehydrogenase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 498.0
SHD2_k127_5618728_19 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 470.0
SHD2_k127_5618728_2 Dehydrogenase E1 component K11381 - 1.2.4.4 0.0 1109.0
SHD2_k127_5618728_20 PFAM Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 486.0
SHD2_k127_5618728_21 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 450.0
SHD2_k127_5618728_22 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 443.0
SHD2_k127_5618728_23 Belongs to the heat shock protein 70 family K04046 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 436.0
SHD2_k127_5618728_24 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000085 434.0
SHD2_k127_5618728_25 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 422.0
SHD2_k127_5618728_26 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 412.0
SHD2_k127_5618728_27 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 383.0
SHD2_k127_5618728_28 Peptidase M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005979 387.0
SHD2_k127_5618728_29 GlcNAc-PI de-N-acetylase K01463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 375.0
SHD2_k127_5618728_3 DNA polymerase X family K02347 - - 2.199e-272 864.0
SHD2_k127_5618728_30 pfam abc K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007886 373.0
SHD2_k127_5618728_31 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 374.0
SHD2_k127_5618728_32 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 366.0
SHD2_k127_5618728_33 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 366.0
SHD2_k127_5618728_34 Dihydrodipicolinate synthetase family K18123 - 4.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 351.0
SHD2_k127_5618728_35 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009739 339.0
SHD2_k127_5618728_36 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 341.0
SHD2_k127_5618728_37 PFAM Chlorite dismutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 330.0
SHD2_k127_5618728_38 Fungal family of unknown function (DUF1776) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 317.0
SHD2_k127_5618728_39 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 315.0
SHD2_k127_5618728_4 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 3.118e-232 733.0
SHD2_k127_5618728_40 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 302.0
SHD2_k127_5618728_41 HAD-hyrolase-like K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006638 298.0
SHD2_k127_5618728_42 PFAM Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005689 291.0
SHD2_k127_5618728_43 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001079 286.0
SHD2_k127_5618728_44 PAS PAC sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001365 285.0
SHD2_k127_5618728_45 TIGRFAM Phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000009867 252.0
SHD2_k127_5618728_46 Phenylacetate-CoA oxygenase K15512 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000000002579 229.0
SHD2_k127_5618728_47 - K01992 - - 0.000000000000000000000000000000000000000000000000000000000005712 231.0
SHD2_k127_5618728_48 CutC family K06201 - - 0.00000000000000000000000000000000000000000000000000000000002877 216.0
SHD2_k127_5618728_49 Carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000001433 205.0
SHD2_k127_5618728_5 Protein conserved in bacteria - - - 1.858e-209 655.0
SHD2_k127_5618728_50 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000001883 196.0
SHD2_k127_5618728_51 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000007762 173.0
SHD2_k127_5618728_52 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.000000000000000000000000000000000000000000002291 175.0
SHD2_k127_5618728_53 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000001199 161.0
SHD2_k127_5618728_54 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000002281 180.0
SHD2_k127_5618728_55 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000009351 164.0
SHD2_k127_5618728_56 Protein of unknown function (DUF420) K08976 - - 0.0000000000000000000000000000000000000002402 155.0
SHD2_k127_5618728_57 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000001296 154.0
SHD2_k127_5618728_58 Cytochrome oxidase assembly protein K02259 - - 0.00000000000000000000000000000000008966 143.0
SHD2_k127_5618728_59 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000001587 141.0
SHD2_k127_5618728_6 ATP-grasp domain K01921 - 6.3.2.4 8.456e-204 637.0
SHD2_k127_5618728_60 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000000000008944 120.0
SHD2_k127_5618728_61 Bacterial regulatory proteins, tetR family K09017 - - 0.00000000000000000000000000003062 126.0
SHD2_k127_5618728_63 Pfam:N_methyl_2 - - - 0.0000000000000000008204 102.0
SHD2_k127_5618728_64 deacetylase K22278 - 3.5.1.104 0.00000000000000009835 91.0
SHD2_k127_5618728_66 - - - - 0.00000000003529 66.0
SHD2_k127_5618728_67 Thioesterase superfamily - - - 0.0000000003479 67.0
SHD2_k127_5618728_68 Domain of unknown function (DUF4440) - - - 0.00000003199 62.0
SHD2_k127_5618728_69 Cupin 2, conserved barrel domain protein - - - 0.00000008347 62.0
SHD2_k127_5618728_7 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 5.827e-202 639.0
SHD2_k127_5618728_70 Regulatory protein, FmdB family - - - 0.0000005779 55.0
SHD2_k127_5618728_71 serine threonine protein kinase - - - 0.000002772 51.0
SHD2_k127_5618728_8 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 6.752e-202 641.0
SHD2_k127_5618728_9 extracellular solute-binding protein, family 5 K02035 - - 7.593e-202 643.0
SHD2_k127_5704122_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 497.0
SHD2_k127_5704122_1 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 297.0
SHD2_k127_5704122_2 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000002428 193.0
SHD2_k127_5704122_3 - - - - 0.0000000000000000007206 89.0
SHD2_k127_5708955_0 Protein of unknown function, DUF255 K06888 - - 1.428e-302 942.0
SHD2_k127_5708955_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 593.0
SHD2_k127_5708955_10 - - - - 0.0000000003501 66.0
SHD2_k127_5708955_2 PA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 589.0
SHD2_k127_5708955_3 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008545 563.0
SHD2_k127_5708955_4 Ferrous iron transport protein B K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 497.0
SHD2_k127_5708955_5 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 479.0
SHD2_k127_5708955_6 PFAM peptidase K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 452.0
SHD2_k127_5708955_7 PAS PAC sensor signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 317.0
SHD2_k127_5708955_8 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000002585 142.0
SHD2_k127_5734887_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 409.0
SHD2_k127_5734887_1 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000957 409.0
SHD2_k127_5734887_2 lipoprotein localization to outer membrane K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008883 352.0
SHD2_k127_5734887_3 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 317.0
SHD2_k127_5734887_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 316.0
SHD2_k127_5734887_5 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001675 262.0
SHD2_k127_5734887_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001013 244.0
SHD2_k127_5734887_7 Belongs to the glycosyl hydrolase 18 family - - - 0.00000000000000000000000000000000000000000000000000000004368 209.0
SHD2_k127_5734887_8 Likely ribonuclease with RNase H fold. K07447 - - 0.0000000000000000000000000000000000000000000000000003149 189.0
SHD2_k127_5796531_0 Heat shock 70 kDa protein K04043 - - 0.0 1076.0
SHD2_k127_5796531_1 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006704 585.0
SHD2_k127_5796531_10 chaperone-mediated protein folding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 343.0
SHD2_k127_5796531_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 310.0
SHD2_k127_5796531_12 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 295.0
SHD2_k127_5796531_13 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 296.0
SHD2_k127_5796531_14 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006021 286.0
SHD2_k127_5796531_15 DJ-1/PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000002469 251.0
SHD2_k127_5796531_16 outer membrane lipoprotein carrier protein LolA K03634 - - 0.00000000000000000000000000000000000000000000000000000000000000003697 227.0
SHD2_k127_5796531_17 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000007174 194.0
SHD2_k127_5796531_18 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000002793 190.0
SHD2_k127_5796531_19 MerR HTH family regulatory protein K13640 - - 0.00000000000000000000000000000000000000000000000001534 182.0
SHD2_k127_5796531_2 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 548.0
SHD2_k127_5796531_20 Pfam:N_methyl_2 - - - 0.00000000000000000000000000000000000000000000001498 175.0
SHD2_k127_5796531_21 Pfam:N_methyl_2 - - - 0.0000000000000000000000000000000000000000000006662 170.0
SHD2_k127_5796531_22 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000000000000000000001324 143.0
SHD2_k127_5796531_23 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000000002831 126.0
SHD2_k127_5796531_24 - - - - 0.0000000000000000000000007509 108.0
SHD2_k127_5796531_26 Protein of unknown function (DUF1161) - - - 0.000000000000672 73.0
SHD2_k127_5796531_27 Protein of unknown function (DUF1440) K08996 - - 0.0004564 50.0
SHD2_k127_5796531_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 499.0
SHD2_k127_5796531_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 488.0
SHD2_k127_5796531_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 435.0
SHD2_k127_5796531_6 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 439.0
SHD2_k127_5796531_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 405.0
SHD2_k127_5796531_8 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 385.0
SHD2_k127_5796531_9 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 353.0
SHD2_k127_5822802_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.014e-237 738.0
SHD2_k127_5822802_1 Domain of unknown function (DUF4139) - - - 0.00000000000000000000000001846 110.0
SHD2_k127_590747_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.262e-290 898.0
SHD2_k127_590747_1 4Fe-4S dicluster domain K00184 - - 5.351e-284 885.0
SHD2_k127_590747_10 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.0000000000002631 74.0
SHD2_k127_590747_11 mandelate racemase muconate lactonizing - - - 0.0000000002456 66.0
SHD2_k127_590747_2 PFAM Polysulphide reductase, NrfD K00185 - - 3.952e-222 696.0
SHD2_k127_590747_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 487.0
SHD2_k127_590747_4 signal sequence binding K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 326.0
SHD2_k127_590747_5 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 319.0
SHD2_k127_590747_6 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 289.0
SHD2_k127_590747_7 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001182 256.0
SHD2_k127_590747_8 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004149 238.0
SHD2_k127_590747_9 - - - - 0.0000000000000002066 87.0
SHD2_k127_5983016_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 2.608e-292 911.0
SHD2_k127_5983016_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.009e-262 816.0
SHD2_k127_5983016_10 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 404.0
SHD2_k127_5983016_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 396.0
SHD2_k127_5983016_12 Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008616 396.0
SHD2_k127_5983016_13 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 392.0
SHD2_k127_5983016_14 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 385.0
SHD2_k127_5983016_15 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 356.0
SHD2_k127_5983016_16 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 362.0
SHD2_k127_5983016_17 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 318.0
SHD2_k127_5983016_18 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 306.0
SHD2_k127_5983016_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 7.742e-237 736.0
SHD2_k127_5983016_20 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009521 277.0
SHD2_k127_5983016_21 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002303 273.0
SHD2_k127_5983016_22 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003193 261.0
SHD2_k127_5983016_23 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001194 261.0
SHD2_k127_5983016_24 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009046,GO:0009605,GO:0009991,GO:0016787,GO:0019538,GO:0031667,GO:0042594,GO:0043170,GO:0044238,GO:0050896,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000005646 224.0
SHD2_k127_5983016_25 - - - - 0.00000000000000000000000000000000000000000000000000000000001993 216.0
SHD2_k127_5983016_26 Putative adhesin - - - 0.000000000000000000000000000000000000000000000000000001157 211.0
SHD2_k127_5983016_27 - - - - 0.00000000000000000000000000000000000000000000000000002444 199.0
SHD2_k127_5983016_28 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000374 199.0
SHD2_k127_5983016_29 2'-5' RNA ligase superfamily - - - 0.000000000000000000000000000000000000000000000000001078 188.0
SHD2_k127_5983016_3 C-terminal, D2-small domain, of ClpB protein - - - 3.215e-214 670.0
SHD2_k127_5983016_30 Putative zinc-finger - - - 0.0000000000000000000000000000000000000000000000001036 186.0
SHD2_k127_5983016_31 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000001276 192.0
SHD2_k127_5983016_32 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000006742 174.0
SHD2_k127_5983016_33 BON domain - - - 0.00000000000000000000000000000000000000000000006275 176.0
SHD2_k127_5983016_34 - - - - 0.0000000000000000000000000000000000000000000001063 173.0
SHD2_k127_5983016_36 - - - - 0.00000000000000000000000000000000002609 142.0
SHD2_k127_5983016_37 cheY-homologous receiver domain K07671 - - 0.00000000000000000000000000001864 121.0
SHD2_k127_5983016_38 Uncharacterized conserved protein (DUF2164) - - - 0.00000000000000000000000000003246 123.0
SHD2_k127_5983016_39 - - - - 0.000000000000000000000001906 105.0
SHD2_k127_5983016_4 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 4.923e-212 662.0
SHD2_k127_5983016_40 PAS domain - - - 0.00000000000000000001531 96.0
SHD2_k127_5983016_41 Putative regulatory protein - - - 0.00000000000000009124 82.0
SHD2_k127_5983016_43 SNARE associated Golgi protein - - - 0.00000000003477 64.0
SHD2_k127_5983016_45 antisigma factor binding K04749,K06378 - - 0.000005759 57.0
SHD2_k127_5983016_47 - - - - 0.00009764 46.0
SHD2_k127_5983016_5 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 1.037e-199 632.0
SHD2_k127_5983016_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 507.0
SHD2_k127_5983016_7 Serine aminopeptidase, S33 K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 439.0
SHD2_k127_5983016_8 PFAM FAD dependent oxidoreductase K15736 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 439.0
SHD2_k127_5983016_9 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 418.0
SHD2_k127_6121453_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1512.0
SHD2_k127_6121453_1 cellulose binding - - - 0.0 1374.0
SHD2_k127_6121453_10 Periplasmic or secreted lipoprotein - - - 0.000000000000000000000000006683 117.0
SHD2_k127_6121453_11 Tetratricopeptide repeat - - - 0.0000000000000000000929 94.0
SHD2_k127_6121453_12 photosystem II stabilization K02237 - - 0.000001619 54.0
SHD2_k127_6121453_13 - - - - 0.000001749 55.0
SHD2_k127_6121453_2 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 339.0
SHD2_k127_6121453_3 WD40-like Beta Propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 325.0
SHD2_k127_6121453_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000271 223.0
SHD2_k127_6121453_5 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000009541 221.0
SHD2_k127_6121453_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000004046 194.0
SHD2_k127_6121453_8 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000001217 178.0
SHD2_k127_6121453_9 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000003162 145.0
SHD2_k127_6177931_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1917.0
SHD2_k127_6177931_1 Peptidase S46 - - - 2.301e-234 743.0
SHD2_k127_6177931_10 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000002773 208.0
SHD2_k127_6177931_11 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000000000000000000000005949 172.0
SHD2_k127_6177931_12 SnoaL-like domain - - - 0.00004392 51.0
SHD2_k127_6177931_2 IMS family HHH motif K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 570.0
SHD2_k127_6177931_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 430.0
SHD2_k127_6177931_4 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 434.0
SHD2_k127_6177931_5 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 404.0
SHD2_k127_6177931_6 3-beta hydroxysteroid dehydrogenase/isomerase family K01784,K10011,K12449 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315 1.1.1.305,2.1.2.13,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 377.0
SHD2_k127_6177931_7 Protein kinase domain K08884 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 353.0
SHD2_k127_6177931_8 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001658 278.0
SHD2_k127_6177931_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000009717 238.0
SHD2_k127_6370431_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 8.58e-199 623.0
SHD2_k127_6370431_1 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 316.0
SHD2_k127_6399541_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.0 1101.0
SHD2_k127_6399541_1 phosphorelay signal transduction system - - - 0.000000000000000000000000000000304 126.0
SHD2_k127_6430386_0 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00138,K00146,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85 0.0 1126.0
SHD2_k127_6430386_1 Amidohydrolase K03392,K22213 - 4.1.1.45,4.1.1.52 8.189e-305 945.0
SHD2_k127_6430386_2 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00138,K00146,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85 1.18e-246 769.0
SHD2_k127_6430386_3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 504.0
SHD2_k127_6430386_4 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K00486 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0019748,GO:0044550,GO:0055114 1.14.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 399.0
SHD2_k127_6430386_5 Cupin 2, conserved barrel domain protein K00452 GO:0000334,GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0044237,GO:0044248,GO:0051213,GO:0055114 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 340.0
SHD2_k127_6430386_6 oxidation-reduction process K01617,K15067 - 3.5.99.5,4.1.1.77 0.000000000000000000000000000000000000000000000000000000003736 202.0
SHD2_k127_6514250_0 domain protein - - - 0.0 1089.0
SHD2_k127_6514250_1 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 5.249e-310 966.0
SHD2_k127_6514250_10 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006854 526.0
SHD2_k127_6514250_11 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 516.0
SHD2_k127_6514250_12 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007811 501.0
SHD2_k127_6514250_13 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 492.0
SHD2_k127_6514250_14 Arginase family K01476 - 3.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 489.0
SHD2_k127_6514250_15 ResB-like family K07399 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 491.0
SHD2_k127_6514250_16 Nucleic acid binding K03698 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 482.0
SHD2_k127_6514250_17 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 488.0
SHD2_k127_6514250_18 peptidase S1 and S6 chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 482.0
SHD2_k127_6514250_19 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 479.0
SHD2_k127_6514250_2 class II (D K K01893 - 6.1.1.22 3.745e-249 775.0
SHD2_k127_6514250_20 Protein involved in outer membrane biogenesis K07289,K07290 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 502.0
SHD2_k127_6514250_21 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 475.0
SHD2_k127_6514250_22 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 448.0
SHD2_k127_6514250_23 PFAM alpha beta hydrolase K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 433.0
SHD2_k127_6514250_24 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 427.0
SHD2_k127_6514250_25 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 413.0
SHD2_k127_6514250_26 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 417.0
SHD2_k127_6514250_27 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 399.0
SHD2_k127_6514250_28 Peptidylprolyl isomerase K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 378.0
SHD2_k127_6514250_29 PFAM Response regulator receiver domain K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 353.0
SHD2_k127_6514250_3 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 4.966e-232 731.0
SHD2_k127_6514250_30 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 339.0
SHD2_k127_6514250_31 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 331.0
SHD2_k127_6514250_32 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 334.0
SHD2_k127_6514250_33 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 325.0
SHD2_k127_6514250_34 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 328.0
SHD2_k127_6514250_35 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 319.0
SHD2_k127_6514250_36 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 318.0
SHD2_k127_6514250_37 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002269 278.0
SHD2_k127_6514250_38 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000299 256.0
SHD2_k127_6514250_39 PASTA domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000005551 260.0
SHD2_k127_6514250_4 Peptidase family M1 domain - - - 1.433e-208 676.0
SHD2_k127_6514250_40 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000007995 239.0
SHD2_k127_6514250_41 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000000000000000000000000000000002103 214.0
SHD2_k127_6514250_42 Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000003537 218.0
SHD2_k127_6514250_43 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000004946 209.0
SHD2_k127_6514250_44 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000000000000000000000000000000000000000000000001537 199.0
SHD2_k127_6514250_45 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000008141 193.0
SHD2_k127_6514250_46 - - - - 0.00000000000000000000000000000000000000000000000009398 181.0
SHD2_k127_6514250_47 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000000000000000009788 186.0
SHD2_k127_6514250_48 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000002624 168.0
SHD2_k127_6514250_49 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000000000008607 161.0
SHD2_k127_6514250_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 608.0
SHD2_k127_6514250_50 Cupin - - - 0.000000000000000000000000000000000000000003603 160.0
SHD2_k127_6514250_51 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000006886 156.0
SHD2_k127_6514250_52 Glutathione peroxidase K02199 - - 0.0000000000000000000000000000000000006803 145.0
SHD2_k127_6514250_53 Prokaryotic N-terminal methylation motif K02650,K02679,K10926,K12285 - - 0.000000000000000000000000000000003941 133.0
SHD2_k127_6514250_54 YjbR - - - 0.0000000000000000000000000000005864 129.0
SHD2_k127_6514250_55 LytTr DNA-binding domain - - - 0.000000000000000000000000000001623 132.0
SHD2_k127_6514250_56 transferase activity, transferring acyl groups K15520 - 2.3.1.189 0.0000000000000000000000000000116 122.0
SHD2_k127_6514250_58 Ribosomal L32p protein family K02911 - - 0.00000000000000000000002295 100.0
SHD2_k127_6514250_59 Tetratricopeptide repeat - - - 0.0000000000000000000001032 106.0
SHD2_k127_6514250_6 PFAM Cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 603.0
SHD2_k127_6514250_60 - - - - 0.0000000000000008167 81.0
SHD2_k127_6514250_61 Acetyltransferase (GNAT) domain - - - 0.00000000000005451 74.0
SHD2_k127_6514250_62 PFAM von Willebrand factor type A - - - 0.0000000000001394 79.0
SHD2_k127_6514250_63 PFAM von Willebrand factor type A - - - 0.00000000000101 76.0
SHD2_k127_6514250_65 Lipocalin-like domain - - - 0.0000000008135 66.0
SHD2_k127_6514250_66 Putative adhesin - - - 0.0000005975 61.0
SHD2_k127_6514250_68 tigrfam pas - - - 0.0005322 49.0
SHD2_k127_6514250_7 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 596.0
SHD2_k127_6514250_8 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 580.0
SHD2_k127_6514250_9 pfam abc K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 549.0
SHD2_k127_6539937_0 CoA binding domain K09181 - - 1.517e-230 721.0
SHD2_k127_661921_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003321 359.0
SHD2_k127_661921_2 Tetratricopeptide repeat - - - 0.000000000001861 80.0
SHD2_k127_6621160_0 Phenazine biosynthesis protein, PhzF family K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 379.0
SHD2_k127_6621160_1 Redoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007005 310.0
SHD2_k127_6621160_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 309.0
SHD2_k127_6621160_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.0000000000000000000000000000000000000000000000000000000000000008029 224.0
SHD2_k127_6621160_4 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000001586 172.0
SHD2_k127_6621160_5 Belongs to the Fur family K09825 - - 0.000000000000000000000000000000000000000000001811 169.0
SHD2_k127_6621160_6 - - - - 0.0006314 45.0
SHD2_k127_6652106_0 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 6.59e-218 687.0
SHD2_k127_6652106_1 TIGRFAM Malto-oligosyltrehalose synthase K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 306.0
SHD2_k127_6652106_2 Peptidylprolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000003263 255.0
SHD2_k127_6682310_0 Belongs to the GSP D family K02453 - - 5.448e-257 815.0
SHD2_k127_6682310_1 Urocanase Rossmann-like domain K01712 - 4.2.1.49 2.154e-216 675.0
SHD2_k127_6682310_2 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006077 248.0
SHD2_k127_6682310_3 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000000000000000000000000000000000000000005773 222.0
SHD2_k127_6682310_4 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000699 206.0
SHD2_k127_6682310_5 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000000000000000000000969 163.0
SHD2_k127_6718892_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 0.0 1046.0
SHD2_k127_6718892_1 PFAM Response regulator receiver domain K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 429.0
SHD2_k127_6718892_2 Molybdopterin dehydrogenase K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 397.0
SHD2_k127_6718892_3 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 339.0
SHD2_k127_6718892_4 Glycine cleavage H-protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004164 265.0
SHD2_k127_6718892_5 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002711 248.0
SHD2_k127_6718892_6 2Fe-2S -binding K13483 - - 0.000000000000000000000000000000000000000000000000000000000000000007717 231.0
SHD2_k127_6718892_7 - - - - 0.000000000000000000000000000000000000000000000001541 177.0
SHD2_k127_6718892_8 - - - - 0.00000000000000000000000000001964 126.0
SHD2_k127_6718892_9 Lactonase, 7-bladed beta-propeller - - - 0.00000002823 64.0
SHD2_k127_6762423_0 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 571.0
SHD2_k127_6762423_1 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003915 256.0
SHD2_k127_6762423_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003193 252.0
SHD2_k127_6762423_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000001026 149.0
SHD2_k127_6792802_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 1.144e-309 963.0
SHD2_k127_6792802_1 GlcNAc-PI de-N-acetylase - - - 1.652e-225 732.0
SHD2_k127_6792802_10 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 549.0
SHD2_k127_6792802_11 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 526.0
SHD2_k127_6792802_12 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 495.0
SHD2_k127_6792802_13 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 463.0
SHD2_k127_6792802_14 Male sterility protein K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 443.0
SHD2_k127_6792802_15 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008813 447.0
SHD2_k127_6792802_16 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 400.0
SHD2_k127_6792802_17 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 398.0
SHD2_k127_6792802_18 Cell division protein FtsQ K03589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 355.0
SHD2_k127_6792802_19 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 310.0
SHD2_k127_6792802_2 Elongator protein 3, MiaB family, Radical SAM - - - 1.425e-218 683.0
SHD2_k127_6792802_20 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000004625 240.0
SHD2_k127_6792802_21 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000000000000000000003554 196.0
SHD2_k127_6792802_23 - K14340 - - 0.000000000000000000000000000000000000004142 161.0
SHD2_k127_6792802_24 DinB superfamily - - - 0.00000000000000000000000000000000000007005 148.0
SHD2_k127_6792802_25 DinB superfamily - - - 0.0000000000000000000000000000000000001178 158.0
SHD2_k127_6792802_26 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0000000000000000000000000000000000001864 150.0
SHD2_k127_6792802_27 - - - - 0.0000000000000000000000000000000000005091 147.0
SHD2_k127_6792802_28 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000006963 133.0
SHD2_k127_6792802_29 cell redox homeostasis - - - 0.0000000000000000000000000000008696 130.0
SHD2_k127_6792802_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 2.416e-209 661.0
SHD2_k127_6792802_30 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.00000000000000000000000000002165 124.0
SHD2_k127_6792802_31 nickel cation binding K04651 - - 0.00000000000000000000000007999 110.0
SHD2_k127_6792802_4 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.044e-202 640.0
SHD2_k127_6792802_5 Cellulase (glycosyl hydrolase family 5) - - - 8.499e-202 634.0
SHD2_k127_6792802_6 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 1.287e-197 621.0
SHD2_k127_6792802_7 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 3.007e-197 624.0
SHD2_k127_6792802_8 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 577.0
SHD2_k127_6792802_9 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 568.0
SHD2_k127_680671_0 TonB-dependent receptor - - - 0.0 1373.0
SHD2_k127_680671_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1327.0
SHD2_k127_680671_10 COG3209 Rhs family protein - - - 1.638e-229 736.0
SHD2_k127_680671_11 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 6.476e-222 715.0
SHD2_k127_680671_12 Lamin Tail Domain K07004 - - 2.414e-207 686.0
SHD2_k127_680671_13 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 9.736e-204 664.0
SHD2_k127_680671_14 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 567.0
SHD2_k127_680671_15 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 533.0
SHD2_k127_680671_16 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 529.0
SHD2_k127_680671_17 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 524.0
SHD2_k127_680671_18 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 492.0
SHD2_k127_680671_19 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 481.0
SHD2_k127_680671_2 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1e-323 1002.0
SHD2_k127_680671_20 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 465.0
SHD2_k127_680671_21 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 440.0
SHD2_k127_680671_22 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 418.0
SHD2_k127_680671_23 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 409.0
SHD2_k127_680671_24 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 363.0
SHD2_k127_680671_25 amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008299 347.0
SHD2_k127_680671_26 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 325.0
SHD2_k127_680671_27 ZIP Zinc transporter K07238,K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 324.0
SHD2_k127_680671_28 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 311.0
SHD2_k127_680671_29 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 300.0
SHD2_k127_680671_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 7.379e-297 920.0
SHD2_k127_680671_30 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 284.0
SHD2_k127_680671_31 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008694 250.0
SHD2_k127_680671_32 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000001495 241.0
SHD2_k127_680671_33 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000006476 192.0
SHD2_k127_680671_34 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000000000000002395 181.0
SHD2_k127_680671_35 - - - - 0.00000000000000000000000000000000000000000000001791 179.0
SHD2_k127_680671_36 TPR repeat - - - 0.00000000000000000000000000000000000000004166 166.0
SHD2_k127_680671_37 Glutaredoxin - - - 0.0000000000000000000000000000000000000003549 151.0
SHD2_k127_680671_38 Serine carboxypeptidase - - - 0.0000000000000000000000000000000000000007126 154.0
SHD2_k127_680671_39 methyltransferase activity K00587 - 2.1.1.100 0.00000000000000000000000000000001183 134.0
SHD2_k127_680671_4 WD40-like Beta Propeller Repeat - - - 2.444e-276 874.0
SHD2_k127_680671_40 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000002706 136.0
SHD2_k127_680671_41 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000000000000001763 127.0
SHD2_k127_680671_42 RESPONSE REGULATOR receiver - - - 0.0000000000000000000000000000004168 126.0
SHD2_k127_680671_43 DsrE/DsrF-like family K06039 - - 0.0000000000000000000000000003426 118.0
SHD2_k127_680671_44 Helix-hairpin-helix motif - - - 0.00000000000000000000003992 111.0
SHD2_k127_680671_45 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000000000007369 100.0
SHD2_k127_680671_46 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000001097 100.0
SHD2_k127_680671_47 Glyoxalase-like domain K01759 - 4.4.1.5 0.00000000000000000000955 96.0
SHD2_k127_680671_49 regulation of circadian rhythm - - - 0.0000000000000000001109 96.0
SHD2_k127_680671_5 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 2.829e-263 828.0
SHD2_k127_680671_50 - - - - 0.0000000000000000001179 91.0
SHD2_k127_680671_52 Tetratricopeptide repeat - - - 0.000000000000001438 83.0
SHD2_k127_680671_53 - - - - 0.00000000000001676 76.0
SHD2_k127_680671_54 - - - - 0.0000000001685 66.0
SHD2_k127_680671_55 - - - - 0.000000005478 61.0
SHD2_k127_680671_56 DNA uptake protein and related DNA-binding K02237 - - 0.000001113 60.0
SHD2_k127_680671_6 C-terminal, D2-small domain, of ClpB protein K03696 - - 7.916e-261 827.0
SHD2_k127_680671_7 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 6.336e-250 785.0
SHD2_k127_680671_8 SpoIVB peptidase S55 - - - 4.843e-243 765.0
SHD2_k127_680671_9 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 1.779e-237 741.0
SHD2_k127_6815589_0 RNA polymerase sigma-54 factor K03092 - - 4.293e-236 742.0
SHD2_k127_6815589_1 lipopolysaccharide transport K09774 - - 9.322e-221 712.0
SHD2_k127_6815589_2 Carboxypeptidase regulatory-like domain - - - 2.963e-219 717.0
SHD2_k127_6815589_3 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006698 575.0
SHD2_k127_6815589_4 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 414.0
SHD2_k127_6815589_5 NIPSNAP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 296.0
SHD2_k127_6815589_6 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 294.0
SHD2_k127_6815589_7 - - - - 0.000000000000000000000000000000000000000003207 171.0
SHD2_k127_6815589_8 RDD family - - - 0.00000000000000000000000000002366 120.0
SHD2_k127_6818130_0 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 3.351e-307 949.0
SHD2_k127_6818130_1 ABC transporter, transmembrane K18890 - - 1.843e-270 845.0
SHD2_k127_6818130_10 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 586.0
SHD2_k127_6818130_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 581.0
SHD2_k127_6818130_12 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 576.0
SHD2_k127_6818130_13 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 530.0
SHD2_k127_6818130_14 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 496.0
SHD2_k127_6818130_15 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 477.0
SHD2_k127_6818130_16 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 476.0
SHD2_k127_6818130_17 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 467.0
SHD2_k127_6818130_18 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008233 456.0
SHD2_k127_6818130_19 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 429.0
SHD2_k127_6818130_2 signal transduction histidine kinase - - - 6.013e-257 812.0
SHD2_k127_6818130_20 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006874 437.0
SHD2_k127_6818130_21 Semialdehyde dehydrogenase K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 414.0
SHD2_k127_6818130_22 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 412.0
SHD2_k127_6818130_23 phosphorelay signal transduction system K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 414.0
SHD2_k127_6818130_24 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 404.0
SHD2_k127_6818130_25 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 398.0
SHD2_k127_6818130_26 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 381.0
SHD2_k127_6818130_27 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 346.0
SHD2_k127_6818130_28 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 337.0
SHD2_k127_6818130_29 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 322.0
SHD2_k127_6818130_3 Two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 1.147e-238 744.0
SHD2_k127_6818130_30 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008927 271.0
SHD2_k127_6818130_31 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000000000004894 220.0
SHD2_k127_6818130_32 Redoxin - - - 0.000000000000000000000000000000000000000000000003351 190.0
SHD2_k127_6818130_33 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000000000000002685 166.0
SHD2_k127_6818130_34 Lipopolysaccharide-assembly - - - 0.0000000000000000000000000000000000000000006265 163.0
SHD2_k127_6818130_35 - - - - 0.000000000000000000000000000000000000000006366 159.0
SHD2_k127_6818130_36 domain, Protein K02450,K07126,K15539 - - 0.0000000000000000000000000000000000000001671 169.0
SHD2_k127_6818130_37 Low affinity iron permease - - - 0.00000000000000000000000000000000000001356 149.0
SHD2_k127_6818130_38 - - - - 0.0000000000000000000000000000000000003365 140.0
SHD2_k127_6818130_39 Putative adhesin - - - 0.000000000000000000000000000000002857 140.0
SHD2_k127_6818130_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 2.546e-208 654.0
SHD2_k127_6818130_40 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000005323 128.0
SHD2_k127_6818130_41 PFAM Peptidase M22, glycoprotease K14742 - - 0.00000000000000000000000000002463 126.0
SHD2_k127_6818130_42 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000008493 125.0
SHD2_k127_6818130_43 - - - - 0.000000000000000000000000183 110.0
SHD2_k127_6818130_44 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000001036 101.0
SHD2_k127_6818130_45 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000003008 98.0
SHD2_k127_6818130_46 PFAM von Willebrand factor type A - - - 0.00000000000000000004458 102.0
SHD2_k127_6818130_47 Protein of unknown function (DUF465) - - - 0.00000000000000004201 83.0
SHD2_k127_6818130_48 - - - - 0.0000000000000001683 87.0
SHD2_k127_6818130_49 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000001032 64.0
SHD2_k127_6818130_5 Tetratricopeptide repeats K12132 - 2.7.11.1 1.056e-206 671.0
SHD2_k127_6818130_50 - - - - 0.000000005811 67.0
SHD2_k127_6818130_51 Domain of unknown function (DUF4412) - - - 0.0000006592 60.0
SHD2_k127_6818130_52 - - - - 0.000003845 55.0
SHD2_k127_6818130_53 Polyketide cyclase / dehydrase and lipid transport - - - 0.00001278 53.0
SHD2_k127_6818130_6 Type II/IV secretion system protein K02669 - - 2.619e-197 619.0
SHD2_k127_6818130_7 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 623.0
SHD2_k127_6818130_8 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 603.0
SHD2_k127_6818130_9 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 594.0
SHD2_k127_6832909_0 Histidine kinase K02478 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 593.0
SHD2_k127_6832909_1 TIGRFAM Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 574.0
SHD2_k127_6832909_2 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 465.0
SHD2_k127_6832909_3 glycosyl transferase group 1 K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 436.0
SHD2_k127_6832909_4 HAD-superfamily hydrolase, subfamily IIB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 302.0
SHD2_k127_6832909_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006536 268.0
SHD2_k127_6832909_6 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000001093 190.0
SHD2_k127_7063778_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1276.0
SHD2_k127_7063778_1 Ribosomal protein S1 K02945 - - 2.203e-319 985.0
SHD2_k127_7063778_10 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 335.0
SHD2_k127_7063778_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009392 335.0
SHD2_k127_7063778_12 Maltogenic Amylase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 321.0
SHD2_k127_7063778_13 (Rhomboid) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004158 269.0
SHD2_k127_7063778_14 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000000000000000008098 239.0
SHD2_k127_7063778_15 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000007626 241.0
SHD2_k127_7063778_16 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000002428 191.0
SHD2_k127_7063778_17 - - - - 0.00000000000000000000000000000000002252 141.0
SHD2_k127_7063778_18 transferase activity, transferring acyl groups K03824,K15520 - 2.3.1.189 0.000000000000000000000000000000006534 132.0
SHD2_k127_7063778_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 7.748e-268 841.0
SHD2_k127_7063778_20 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000001072 96.0
SHD2_k127_7063778_21 - - - - 0.0000000005323 64.0
SHD2_k127_7063778_22 - K05826 - - 0.0000000005691 63.0
SHD2_k127_7063778_25 heme oxygenase (decyclizing) activity - - - 0.0006473 47.0
SHD2_k127_7063778_26 Protein of unknown function (DUF1579) - - - 0.0008867 52.0
SHD2_k127_7063778_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007541 591.0
SHD2_k127_7063778_4 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000725 588.0
SHD2_k127_7063778_5 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 535.0
SHD2_k127_7063778_6 Belongs to the peptidase S8 family K13275 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 475.0
SHD2_k127_7063778_7 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 445.0
SHD2_k127_7063778_8 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 395.0
SHD2_k127_7063778_9 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007121 362.0
SHD2_k127_7136006_0 PFAM peptidase M13 K01415 - 3.4.24.71 9.217e-199 641.0
SHD2_k127_7136006_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 610.0
SHD2_k127_7136006_10 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000004523 98.0
SHD2_k127_7136006_11 Anti-sigma-K factor rskA - - - 0.0000008977 53.0
SHD2_k127_7136006_2 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 535.0
SHD2_k127_7136006_3 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 323.0
SHD2_k127_7136006_4 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003355 262.0
SHD2_k127_7136006_5 Phosphoesterase family K21302 - 3.1.3.64 0.0000000000000000000000000000000000000000000000000000000000000000000002506 252.0
SHD2_k127_7136006_6 Domain of unknown function (DUF4126) - - - 0.00000000000000000000000000000000000000000000000000000000000000002774 228.0
SHD2_k127_7136006_7 PAS PAC sensor signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000001672 213.0
SHD2_k127_7136006_8 - - - - 0.00000000000000000000000000000000000000000005318 160.0
SHD2_k127_7136006_9 Protein of unknown function (DUF962) - - - 0.0000000000000000000000000000000001001 136.0
SHD2_k127_7155479_0 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000003476 198.0
SHD2_k127_7155479_1 - - - - 0.000000000000000000000000000000000000000879 151.0
SHD2_k127_7155479_2 cell adhesion involved in biofilm formation - - - 0.0000002214 61.0
SHD2_k127_7189690_0 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 592.0
SHD2_k127_7189690_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 523.0
SHD2_k127_7189690_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004373 284.0
SHD2_k127_7189690_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K00082 - 1.1.1.193 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004432 273.0
SHD2_k127_7189690_4 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000008956 236.0
SHD2_k127_7189690_5 HD domain - - - 0.00000000000000000000000000000000000000000000000000000001325 204.0
SHD2_k127_7189690_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000002056 135.0
SHD2_k127_7189690_7 - - - - 0.0000000000000000000000000000005066 125.0
SHD2_k127_723072_0 PFAM glycoside hydrolase family 3 K05349 - 3.2.1.21 0.0 1039.0
SHD2_k127_723072_1 ASPIC and UnbV - - - 5.582e-286 886.0
SHD2_k127_723072_2 Histidine kinase - - - 1.099e-200 634.0
SHD2_k127_723072_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 439.0
SHD2_k127_723072_4 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 377.0
SHD2_k127_723072_5 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 321.0
SHD2_k127_723072_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 316.0
SHD2_k127_723072_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001058 268.0
SHD2_k127_723072_8 - - - - 0.0000000000000000000000000000000000000000000000000000005297 214.0
SHD2_k127_723072_9 - - - - 0.0000000000000000000000000000000000000000005455 163.0
SHD2_k127_7326113_0 Sortilin, neurotensin receptor 3, - - - 0.0 1557.0
SHD2_k127_7326113_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0 1062.0
SHD2_k127_7326113_10 Bacterial regulatory protein, Fis family - - - 7.737e-235 736.0
SHD2_k127_7326113_100 phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000003781 209.0
SHD2_k127_7326113_101 AMMECR1 K09141 - - 0.0000000000000000000000000000000000000000000000000000000003235 207.0
SHD2_k127_7326113_102 PFAM Uncharacterised protein family UPF0126 - - - 0.000000000000000000000000000000000000000000000000000000009846 205.0
SHD2_k127_7326113_103 molybdenum ion binding K07140 - - 0.00000000000000000000000000000000000000000000000000000003947 202.0
SHD2_k127_7326113_104 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000001913 205.0
SHD2_k127_7326113_105 - - - - 0.0000000000000000000000000000000000000000000000000000002746 208.0
SHD2_k127_7326113_106 Ribose/Galactose Isomerase K01808,K01819,K21911 GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0008150,GO:0008152,GO:0009056,GO:0009743,GO:0009758,GO:0009987,GO:0010033,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0042221,GO:0044238,GO:0050896,GO:0051716,GO:0070887,GO:0071310,GO:0071322,GO:0071704,GO:1901575,GO:1901700,GO:1901701 5.3.1.26,5.3.1.34,5.3.1.6 0.0000000000000000000000000000000000000000000000000000003103 197.0
SHD2_k127_7326113_107 Belongs to the TrpC family K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000137 202.0
SHD2_k127_7326113_109 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000002015 200.0
SHD2_k127_7326113_11 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K05587 - 1.6.5.3 2.981e-224 707.0
SHD2_k127_7326113_110 nucleotidyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000008055 195.0
SHD2_k127_7326113_111 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.0000000000000000000000000000000000000000000000000000821 188.0
SHD2_k127_7326113_112 Serine hydrolase K07002 - - 0.0000000000000000000000000000000000000000000000000003535 190.0
SHD2_k127_7326113_113 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000004668 191.0
SHD2_k127_7326113_114 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000005264 183.0
SHD2_k127_7326113_115 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000004869 175.0
SHD2_k127_7326113_116 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000008581 178.0
SHD2_k127_7326113_117 - - - - 0.0000000000000000000000000000000000000000000001223 171.0
SHD2_k127_7326113_118 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000001585 178.0
SHD2_k127_7326113_119 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000003596 175.0
SHD2_k127_7326113_12 Phytochrome central region domain protein - - - 9.412e-224 716.0
SHD2_k127_7326113_120 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000004719 167.0
SHD2_k127_7326113_121 - - - - 0.00000000000000000000000000000000000000001251 155.0
SHD2_k127_7326113_122 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000001199 164.0
SHD2_k127_7326113_123 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000009908 152.0
SHD2_k127_7326113_124 Met-10+ like-protein - - - 0.00000000000000000000000000000000000000127 156.0
SHD2_k127_7326113_125 Hexameric tyrosine-coordinated heme protein (HTHP) - - - 0.0000000000000000000000000000000000009007 141.0
SHD2_k127_7326113_127 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000000002257 135.0
SHD2_k127_7326113_128 competence protein - - - 0.000000000000000000000000000000000802 136.0
SHD2_k127_7326113_129 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000000002002 130.0
SHD2_k127_7326113_13 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.353e-222 696.0
SHD2_k127_7326113_130 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000003056 134.0
SHD2_k127_7326113_131 4Fe-4S dicluster domain K00176 - 1.2.7.3 0.00000000000000000000000000000002217 128.0
SHD2_k127_7326113_134 - - - - 0.000000000000000000000000000003336 123.0
SHD2_k127_7326113_135 heme oxygenase - - - 0.000000000000000000000000000005462 127.0
SHD2_k127_7326113_136 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000002593 125.0
SHD2_k127_7326113_137 sirohydrochlorin cobaltochelatase activity K03794,K03795 - 4.99.1.3,4.99.1.4 0.00000000000000000000000000008168 123.0
SHD2_k127_7326113_138 - - - - 0.0000000000000000000000000001757 125.0
SHD2_k127_7326113_139 Biotin-requiring enzyme K17490 - 2.1.3.1 0.0000000000000000000000000001964 119.0
SHD2_k127_7326113_14 Carboxypeptidase regulatory-like domain - - - 3.175e-222 728.0
SHD2_k127_7326113_140 - - - - 0.0000000000000000000000004446 106.0
SHD2_k127_7326113_141 TIGRFAM hydrogenase maturation protease - - - 0.000000000000000000000001736 108.0
SHD2_k127_7326113_142 - - - - 0.00000000000000000000000534 109.0
SHD2_k127_7326113_143 carbon dioxide binding K04653 - - 0.00000000000000000000009663 109.0
SHD2_k127_7326113_144 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000000005858 102.0
SHD2_k127_7326113_145 - - - - 0.000000000000000000004861 103.0
SHD2_k127_7326113_146 - - - - 0.00000000000000000001393 103.0
SHD2_k127_7326113_147 phosphorelay signal transduction system - - - 0.000000000000000008642 88.0
SHD2_k127_7326113_148 Ankyrin repeat K06867 - - 0.000000000000000212 92.0
SHD2_k127_7326113_149 - - - - 0.0000000000000007555 79.0
SHD2_k127_7326113_15 TIGRFAM VWFA-related Acidobacterial domain - - - 1.054e-221 708.0
SHD2_k127_7326113_153 Tetratricopeptide repeat - - - 0.00000000000008009 76.0
SHD2_k127_7326113_154 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K02395 - - 0.000000000001577 75.0
SHD2_k127_7326113_155 - - - - 0.000000000002424 74.0
SHD2_k127_7326113_157 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.0000000000257 69.0
SHD2_k127_7326113_158 cyclic nucleotide binding K01420,K21556,K21562 - - 0.00000000003132 74.0
SHD2_k127_7326113_159 - - - - 0.0000000000798 74.0
SHD2_k127_7326113_16 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 1.127e-220 693.0
SHD2_k127_7326113_160 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.0000000001359 67.0
SHD2_k127_7326113_161 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000007142 68.0
SHD2_k127_7326113_162 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000008848 59.0
SHD2_k127_7326113_163 Amidohydrolase K07045 - - 0.00001758 56.0
SHD2_k127_7326113_164 Lipid A 3-O-deacylase (PagL) - - - 0.00002146 55.0
SHD2_k127_7326113_167 - - - - 0.0002033 49.0
SHD2_k127_7326113_17 PFAM glycosyl transferase family 39 - - - 3.895e-215 684.0
SHD2_k127_7326113_18 Sigma factor PP2C-like phosphatases - - - 5.872e-210 669.0
SHD2_k127_7326113_19 Nickel-dependent hydrogenase K00436 - 1.12.1.2 1.314e-199 632.0
SHD2_k127_7326113_2 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.0 1023.0
SHD2_k127_7326113_20 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 1.371e-196 632.0
SHD2_k127_7326113_21 e3 binding domain K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 613.0
SHD2_k127_7326113_22 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 606.0
SHD2_k127_7326113_23 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 599.0
SHD2_k127_7326113_24 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 565.0
SHD2_k127_7326113_25 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009539 565.0
SHD2_k127_7326113_26 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007961 562.0
SHD2_k127_7326113_27 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 557.0
SHD2_k127_7326113_28 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005724 555.0
SHD2_k127_7326113_29 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 547.0
SHD2_k127_7326113_3 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 1.145e-317 978.0
SHD2_k127_7326113_30 Acetyl-CoA hydrolase/transferase N-terminal domain K01067 - 3.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 550.0
SHD2_k127_7326113_31 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 544.0
SHD2_k127_7326113_32 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 511.0
SHD2_k127_7326113_33 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 540.0
SHD2_k127_7326113_34 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 500.0
SHD2_k127_7326113_35 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 497.0
SHD2_k127_7326113_36 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 492.0
SHD2_k127_7326113_37 Abhydrolase domain containing 18 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 492.0
SHD2_k127_7326113_38 Electron transfer flavoprotein FAD-binding domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008074 487.0
SHD2_k127_7326113_39 Dehydrogenase E1 component K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 473.0
SHD2_k127_7326113_4 PFAM HypF finger K04656 - - 1.437e-299 939.0
SHD2_k127_7326113_40 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 463.0
SHD2_k127_7326113_41 Manganese containing catalase K07217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008376 460.0
SHD2_k127_7326113_42 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 455.0
SHD2_k127_7326113_43 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 441.0
SHD2_k127_7326113_44 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002055 443.0
SHD2_k127_7326113_45 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 441.0
SHD2_k127_7326113_46 lactate/malate dehydrogenase, alpha/beta C-terminal domain K00016 - 1.1.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 430.0
SHD2_k127_7326113_47 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 422.0
SHD2_k127_7326113_48 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 424.0
SHD2_k127_7326113_49 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 426.0
SHD2_k127_7326113_5 Protein tyrosine kinase - - - 4.018e-273 865.0
SHD2_k127_7326113_50 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 432.0
SHD2_k127_7326113_51 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 411.0
SHD2_k127_7326113_52 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 404.0
SHD2_k127_7326113_53 TIGRFAM hopanoid biosynthesis associated glycosyl transferase protein HpnI K00720 - 2.4.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 392.0
SHD2_k127_7326113_54 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 389.0
SHD2_k127_7326113_55 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 383.0
SHD2_k127_7326113_56 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 385.0
SHD2_k127_7326113_57 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 383.0
SHD2_k127_7326113_58 Enoyl-CoA hydratase/isomerase K01715,K07537 - 4.2.1.100,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007381 378.0
SHD2_k127_7326113_59 PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K05299,K05588 - 1.17.1.10,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007643 374.0
SHD2_k127_7326113_6 Conserved carboxylase domain K03416 - 2.1.3.1 1.887e-262 814.0
SHD2_k127_7326113_60 Phosphoesterase family K01114 - 3.1.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 366.0
SHD2_k127_7326113_61 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009308 345.0
SHD2_k127_7326113_62 Formate/nitrite transporter K21990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 338.0
SHD2_k127_7326113_63 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 336.0
SHD2_k127_7326113_64 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 337.0
SHD2_k127_7326113_65 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 331.0
SHD2_k127_7326113_66 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006069 323.0
SHD2_k127_7326113_67 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 322.0
SHD2_k127_7326113_68 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 334.0
SHD2_k127_7326113_69 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 311.0
SHD2_k127_7326113_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 7.964e-262 817.0
SHD2_k127_7326113_70 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 307.0
SHD2_k127_7326113_71 - K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 307.0
SHD2_k127_7326113_72 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 306.0
SHD2_k127_7326113_73 Copper binding periplasmic protein CusF K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 303.0
SHD2_k127_7326113_74 domain protein K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000927 313.0
SHD2_k127_7326113_75 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 304.0
SHD2_k127_7326113_76 Gas vesicle - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 299.0
SHD2_k127_7326113_77 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 293.0
SHD2_k127_7326113_78 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 291.0
SHD2_k127_7326113_79 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000621 288.0
SHD2_k127_7326113_8 CoA carboxylase activity K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 1.186e-248 776.0
SHD2_k127_7326113_80 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005524 273.0
SHD2_k127_7326113_81 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007945 274.0
SHD2_k127_7326113_82 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002052 275.0
SHD2_k127_7326113_83 PFAM Cupin 2, conserved barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000103 263.0
SHD2_k127_7326113_84 anthranilate K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000003884 257.0
SHD2_k127_7326113_85 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003705 254.0
SHD2_k127_7326113_86 lipid kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006363 261.0
SHD2_k127_7326113_87 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001693 263.0
SHD2_k127_7326113_88 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000003328 254.0
SHD2_k127_7326113_89 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000004528 237.0
SHD2_k127_7326113_9 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 2.424e-245 772.0
SHD2_k127_7326113_90 Ferritin-like domain K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000021 236.0
SHD2_k127_7326113_91 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000002367 235.0
SHD2_k127_7326113_92 HD domain K07023 - - 0.000000000000000000000000000000000000000000000000000000000000000028 228.0
SHD2_k127_7326113_93 - - - - 0.00000000000000000000000000000000000000000000000000000000000000008579 234.0
SHD2_k127_7326113_94 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000001784 233.0
SHD2_k127_7326113_95 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000005508 231.0
SHD2_k127_7326113_96 Thioredoxin-like [2Fe-2S] ferredoxin K05586 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000006539 224.0
SHD2_k127_7326113_97 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14128,K18007 - 1.12.1.2,1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000008671 222.0
SHD2_k127_7326113_98 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000001254 226.0
SHD2_k127_7326113_99 - - - - 0.00000000000000000000000000000000000000000000000000000000001 212.0
SHD2_k127_7339437_0 ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.0 1086.0
SHD2_k127_7339437_1 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K07303 - 1.3.99.16 2.444e-263 829.0
SHD2_k127_7339437_10 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 445.0
SHD2_k127_7339437_11 aminopeptidase N - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004925 455.0
SHD2_k127_7339437_12 Two component transcriptional regulator, LytTR family K02477,K07705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 410.0
SHD2_k127_7339437_13 Aminotransferase class-V K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 399.0
SHD2_k127_7339437_14 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 377.0
SHD2_k127_7339437_15 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 375.0
SHD2_k127_7339437_16 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 366.0
SHD2_k127_7339437_17 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004377 359.0
SHD2_k127_7339437_18 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 334.0
SHD2_k127_7339437_19 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001312 283.0
SHD2_k127_7339437_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 7.569e-239 754.0
SHD2_k127_7339437_20 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005488 280.0
SHD2_k127_7339437_21 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001576 271.0
SHD2_k127_7339437_22 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006742 266.0
SHD2_k127_7339437_23 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K07302,K07303 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000004202 252.0
SHD2_k127_7339437_24 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000001215 220.0
SHD2_k127_7339437_25 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000000000000000000000000006966 227.0
SHD2_k127_7339437_26 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000002517 225.0
SHD2_k127_7339437_27 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.0000000000000000000000000000000000000000000000000000000005345 211.0
SHD2_k127_7339437_28 - - - - 0.000000000000000000000000000000000000000000000000000002083 198.0
SHD2_k127_7339437_29 Lipocalin / cytosolic fatty-acid binding protein family K03098 - - 0.000000000000000000000000000000000000000000000000000008794 194.0
SHD2_k127_7339437_3 Beta-Casp domain K07576 - - 1.95e-228 715.0
SHD2_k127_7339437_30 Predicted membrane protein (DUF2306) - - - 0.00000000000000000000000000000000000000000000000001002 188.0
SHD2_k127_7339437_31 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000001008 190.0
SHD2_k127_7339437_32 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.0000000000000000000000000000000000000002613 154.0
SHD2_k127_7339437_33 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000008587 131.0
SHD2_k127_7339437_34 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000004672 119.0
SHD2_k127_7339437_35 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.00000000000000000000000005252 109.0
SHD2_k127_7339437_36 DsrE/DsrF-like family K09004 - - 0.0000000000000135 79.0
SHD2_k127_7339437_37 Antibiotic biosynthesis monooxygenase - - - 0.00000000000001563 77.0
SHD2_k127_7339437_38 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000104 62.0
SHD2_k127_7339437_39 Transcriptional regulatory protein, C terminal K02483 - - 0.000776 48.0
SHD2_k127_7339437_4 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 8.557e-227 708.0
SHD2_k127_7339437_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 4.699e-196 617.0
SHD2_k127_7339437_6 aminoacyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 538.0
SHD2_k127_7339437_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 525.0
SHD2_k127_7339437_8 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 504.0
SHD2_k127_7339437_9 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 475.0
SHD2_k127_7351380_0 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 548.0
SHD2_k127_7351380_1 Peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008184 326.0
SHD2_k127_7351380_2 homoserine transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000002463 209.0
SHD2_k127_7365933_0 Aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 5.42e-218 680.0
SHD2_k127_7365933_1 Aminotransferase class I and II K14260 - 2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 578.0
SHD2_k127_7365933_2 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 582.0
SHD2_k127_7365933_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 542.0
SHD2_k127_7365933_4 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000000000000000002005 96.0
SHD2_k127_7365933_5 membrane protein (DUF2306) - - - 0.00000000000000000005261 98.0
SHD2_k127_7365933_6 TonB-dependent siderophore receptor K02014 - - 0.000000000000000001375 101.0
SHD2_k127_7374710_0 PFAM Amidase - - - 1.32e-221 702.0
SHD2_k127_7374710_1 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 612.0
SHD2_k127_7374710_10 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000001966 243.0
SHD2_k127_7374710_11 PLD-like domain - - - 0.0000000000000000000000000000000000000000000000000000002608 201.0
SHD2_k127_7374710_12 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000009432 193.0
SHD2_k127_7374710_13 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase - - - 0.0000000000000000000000000007448 117.0
SHD2_k127_7374710_14 integral membrane protein - - - 0.000000000000000003774 93.0
SHD2_k127_7374710_15 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000004009 84.0
SHD2_k127_7374710_16 Horizontally Transferred TransMembrane Domain - - - 0.0000000000001341 75.0
SHD2_k127_7374710_19 - - - - 0.0001912 48.0
SHD2_k127_7374710_2 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 459.0
SHD2_k127_7374710_3 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 400.0
SHD2_k127_7374710_4 D-ala-D-ala dipeptidase K08641 - 3.4.13.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005922 346.0
SHD2_k127_7374710_5 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 340.0
SHD2_k127_7374710_6 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 328.0
SHD2_k127_7374710_7 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000527 302.0
SHD2_k127_7374710_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003651 251.0
SHD2_k127_7374710_9 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000001612 241.0
SHD2_k127_7392820_0 Protein of unknown function (DUF1009) K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 425.0
SHD2_k127_7392820_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004799 392.0
SHD2_k127_7392820_2 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 387.0
SHD2_k127_7392820_3 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 378.0
SHD2_k127_7392820_4 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001499 252.0
SHD2_k127_7392820_5 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000002895 246.0
SHD2_k127_7392820_6 TonB C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000002041 237.0
SHD2_k127_7456772_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1280.0
SHD2_k127_7456772_1 PFAM Cytochrome c assembly protein K02198 - - 2.065e-309 960.0
SHD2_k127_7456772_10 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 572.0
SHD2_k127_7456772_11 Alpha-L-fucosidase K01206 - 3.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005587 542.0
SHD2_k127_7456772_12 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 527.0
SHD2_k127_7456772_13 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 522.0
SHD2_k127_7456772_14 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 503.0
SHD2_k127_7456772_15 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 521.0
SHD2_k127_7456772_16 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 490.0
SHD2_k127_7456772_17 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009246 482.0
SHD2_k127_7456772_18 FAE1/Type III polyketide synthase-like protein K16167 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 451.0
SHD2_k127_7456772_19 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 441.0
SHD2_k127_7456772_2 B12 binding domain - - - 2.336e-270 838.0
SHD2_k127_7456772_20 Nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 406.0
SHD2_k127_7456772_21 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 401.0
SHD2_k127_7456772_22 Coenzyme A transferase K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 391.0
SHD2_k127_7456772_23 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 390.0
SHD2_k127_7456772_24 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 384.0
SHD2_k127_7456772_25 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 357.0
SHD2_k127_7456772_26 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 359.0
SHD2_k127_7456772_27 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 370.0
SHD2_k127_7456772_28 Coenzyme A transferase K01029 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 353.0
SHD2_k127_7456772_29 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 350.0
SHD2_k127_7456772_3 B12 binding domain - - - 7.294e-245 765.0
SHD2_k127_7456772_30 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 340.0
SHD2_k127_7456772_31 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 334.0
SHD2_k127_7456772_32 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 319.0
SHD2_k127_7456772_33 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 318.0
SHD2_k127_7456772_34 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 323.0
SHD2_k127_7456772_35 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 320.0
SHD2_k127_7456772_36 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 288.0
SHD2_k127_7456772_37 MFS/sugar transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 299.0
SHD2_k127_7456772_38 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 282.0
SHD2_k127_7456772_39 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007269 279.0
SHD2_k127_7456772_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 6.178e-226 707.0
SHD2_k127_7456772_40 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000354 262.0
SHD2_k127_7456772_41 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002388 248.0
SHD2_k127_7456772_42 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000002607 249.0
SHD2_k127_7456772_43 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000007939 242.0
SHD2_k127_7456772_44 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000000000000000000000000000000000000003145 235.0
SHD2_k127_7456772_45 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004 237.0
SHD2_k127_7456772_46 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000002911 228.0
SHD2_k127_7456772_47 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000002349 228.0
SHD2_k127_7456772_48 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000006972 226.0
SHD2_k127_7456772_49 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000000000000000002248 222.0
SHD2_k127_7456772_5 B12 binding domain - - - 4.09e-212 667.0
SHD2_k127_7456772_50 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000003561 222.0
SHD2_k127_7456772_51 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000000000000048 217.0
SHD2_k127_7456772_52 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000003182 207.0
SHD2_k127_7456772_53 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000007122 205.0
SHD2_k127_7456772_54 - - - - 0.0000000000000000000000000000000000000000000000000000000002289 207.0
SHD2_k127_7456772_55 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0000000000000000000000000000000000000000000000000000000002986 214.0
SHD2_k127_7456772_56 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000109 203.0
SHD2_k127_7456772_57 peroxiredoxin, OsmC subfamily K04063 - - 0.0000000000000000000000000000000000000000000000000001243 188.0
SHD2_k127_7456772_58 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000008246 172.0
SHD2_k127_7456772_6 Bacterial protein of unknown function (DUF885) - - - 2.619e-210 668.0
SHD2_k127_7456772_60 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000002581 175.0
SHD2_k127_7456772_61 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000000000000000000000004452 167.0
SHD2_k127_7456772_62 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000000009007 164.0
SHD2_k127_7456772_64 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000002703 156.0
SHD2_k127_7456772_65 subunit of a heme lyase K02200 - - 0.00000000000000000000000000000000000000002758 157.0
SHD2_k127_7456772_66 recA bacterial DNA recombination protein - - - 0.0000000000000000000000000000000000000004012 161.0
SHD2_k127_7456772_67 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000000003378 143.0
SHD2_k127_7456772_69 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000235 137.0
SHD2_k127_7456772_7 radical SAM domain protein - - - 5.352e-195 624.0
SHD2_k127_7456772_70 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000001559 128.0
SHD2_k127_7456772_71 PFAM cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.00000000000000000000000000000001884 129.0
SHD2_k127_7456772_72 PFAM response regulator receiver - - - 0.0000000000000000000000000000002636 128.0
SHD2_k127_7456772_73 Cold shock protein K03704 - - 0.0000000000000000000000000000003992 126.0
SHD2_k127_7456772_74 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000001675 121.0
SHD2_k127_7456772_75 Ribosomal protein L30 K02907 - - 0.00000000000000000000000004409 109.0
SHD2_k127_7456772_76 PFAM Chorismate mutase, type II - - - 0.00000000000000000000000004675 110.0
SHD2_k127_7456772_77 - - - - 0.0000000000000000000001663 100.0
SHD2_k127_7456772_78 - - - - 0.0000000000000000000007656 96.0
SHD2_k127_7456772_79 - - - - 0.000000000000000000001763 100.0
SHD2_k127_7456772_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005675 604.0
SHD2_k127_7456772_80 - - - - 0.000000000000000000004939 96.0
SHD2_k127_7456772_81 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000003311 83.0
SHD2_k127_7456772_82 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.00000000000000003384 93.0
SHD2_k127_7456772_83 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000002431 76.0
SHD2_k127_7456772_85 PFAM PKD domain containing protein - - - 0.000000000000458 83.0
SHD2_k127_7456772_86 - - - - 0.00000000003316 67.0
SHD2_k127_7456772_87 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000001646 54.0
SHD2_k127_7456772_9 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 579.0
SHD2_k127_7456772_92 Protein of unknown function (DUF2934) - - - 0.0000621 48.0
SHD2_k127_7475506_0 Mur ligase middle domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007205 544.0
SHD2_k127_7475506_1 LD-carboxypeptidase K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000001928 177.0
SHD2_k127_7510186_0 PFAM peptidase K16922 - - 0.0000000000000000000000000000000000000000000000001534 200.0
SHD2_k127_7510186_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.0000000000000000000000000000000000000000000000001882 199.0
SHD2_k127_7510186_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000005326 101.0
SHD2_k127_7510186_3 Fis family transcriptional regulator K10941 - - 0.00004516 48.0
SHD2_k127_7540743_0 Belongs to the CinA family K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 526.0
SHD2_k127_7540743_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 488.0
SHD2_k127_7540743_2 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 472.0
SHD2_k127_7540743_3 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 425.0
SHD2_k127_7540743_4 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000005437 231.0
SHD2_k127_7540743_5 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000001276 197.0
SHD2_k127_7540743_6 PFAM Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.0000000000000000000000000000000000000000000000004725 181.0
SHD2_k127_7540743_7 2'-5' RNA ligase superfamily K01975 - 3.1.4.58 0.000000000000000000000000000000000000000000000001754 184.0
SHD2_k127_7589031_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1596.0
SHD2_k127_7589031_1 PFAM peptidase - - - 1.335e-245 766.0
SHD2_k127_7589031_10 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005433 257.0
SHD2_k127_7589031_11 PFAM Colicin V production K03558 - - 0.000000000000000000000000000000000000000000000000000003224 196.0
SHD2_k127_7589031_12 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000000004673 157.0
SHD2_k127_7589031_13 - - - - 0.0000000000000000000000000000000000004265 147.0
SHD2_k127_7589031_14 Ankyrin repeat - - - 0.0000000000000000000000000000000000008078 149.0
SHD2_k127_7589031_15 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000007546 141.0
SHD2_k127_7589031_16 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000004059 137.0
SHD2_k127_7589031_17 DinB superfamily - - - 0.000000000000000000000000000000000247 138.0
SHD2_k127_7589031_18 YtxH-like protein - - - 0.0000000000000000000000000000001483 127.0
SHD2_k127_7589031_19 Aldo/keto reductase family - - - 0.00000000000000000000000006286 111.0
SHD2_k127_7589031_2 Peptidase S46 - - - 3.413e-222 710.0
SHD2_k127_7589031_20 Phospholipid methyltransferase - - - 0.000000000000000000000000505 112.0
SHD2_k127_7589031_21 - - - - 0.00000001171 61.0
SHD2_k127_7589031_3 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.014e-196 617.0
SHD2_k127_7589031_4 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 602.0
SHD2_k127_7589031_5 PFAM aminotransferase class V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 547.0
SHD2_k127_7589031_6 SAICAR synthetase K01923,K13713 - 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 469.0
SHD2_k127_7589031_7 oxidoreductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 325.0
SHD2_k127_7589031_8 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001104 280.0
SHD2_k127_7589031_9 Phosphoesterase family K21302 - 3.1.3.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000004479 267.0
SHD2_k127_7593806_0 Glutamine--fructose-6-phosphate aminotransferase isomerizing K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 414.0
SHD2_k127_7593806_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 291.0
SHD2_k127_7593806_2 PFAM Ribonuclease II K01147 - 3.1.13.1 0.000000000000000000000000005198 111.0
SHD2_k127_7603015_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009406 501.0
SHD2_k127_7603015_1 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 324.0
SHD2_k127_7603015_3 - - - - 0.00000000000000000000000209 103.0
SHD2_k127_7631712_0 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 447.0
SHD2_k127_7631712_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000007115 237.0
SHD2_k127_7631712_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000000000003062 232.0
SHD2_k127_7631712_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000002565 225.0
SHD2_k127_7631712_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000002321 190.0
SHD2_k127_7631712_5 lipoprotein localization to outer membrane K02004 - - 0.00000000000000000000000000000000000000000000002192 173.0
SHD2_k127_7631712_6 xylan catabolic process - - - 0.000000000000000000000000000000000000000007358 174.0
SHD2_k127_7688046_0 Arginosuccinate synthase K01940 - 6.3.4.5 1.717e-204 642.0
SHD2_k127_7688046_1 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009875 578.0
SHD2_k127_7688046_2 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 439.0
SHD2_k127_7688046_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 429.0
SHD2_k127_7688046_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004606 409.0
SHD2_k127_7688046_5 Acetyltransferase (GNAT) family K00619 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000008708 204.0
SHD2_k127_7688046_6 - - - - 0.000000000000000000000000000000000000005409 156.0
SHD2_k127_7688046_7 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000000000000009567 144.0
SHD2_k127_7770483_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 386.0
SHD2_k127_7770483_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 297.0
SHD2_k127_7876060_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1144.0
SHD2_k127_7876060_1 peptidase K01415,K07386 - 3.4.24.71 2.513e-272 853.0
SHD2_k127_7876060_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 5.127e-206 647.0
SHD2_k127_7876060_11 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 4.619e-201 642.0
SHD2_k127_7876060_12 Involved in the tonB-independent uptake of proteins - - - 6.081e-197 643.0
SHD2_k127_7876060_13 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 592.0
SHD2_k127_7876060_14 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 589.0
SHD2_k127_7876060_15 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 583.0
SHD2_k127_7876060_16 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 563.0
SHD2_k127_7876060_17 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005149 566.0
SHD2_k127_7876060_18 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 556.0
SHD2_k127_7876060_19 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 499.0
SHD2_k127_7876060_2 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 5.721e-263 820.0
SHD2_k127_7876060_20 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 449.0
SHD2_k127_7876060_21 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 430.0
SHD2_k127_7876060_22 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005014 427.0
SHD2_k127_7876060_23 pfam abc K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007681 407.0
SHD2_k127_7876060_24 Cation efflux family K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 397.0
SHD2_k127_7876060_25 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 383.0
SHD2_k127_7876060_26 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 358.0
SHD2_k127_7876060_27 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 363.0
SHD2_k127_7876060_28 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 342.0
SHD2_k127_7876060_29 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 325.0
SHD2_k127_7876060_3 Dienelactone hydrolase family - - - 1.206e-245 776.0
SHD2_k127_7876060_30 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 324.0
SHD2_k127_7876060_31 Uncharacterized conserved protein (COG2071) K09166 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 312.0
SHD2_k127_7876060_32 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 310.0
SHD2_k127_7876060_33 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 286.0
SHD2_k127_7876060_34 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002376 286.0
SHD2_k127_7876060_35 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001078 277.0
SHD2_k127_7876060_36 YbbR-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001823 230.0
SHD2_k127_7876060_37 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000005353 223.0
SHD2_k127_7876060_38 D-Tyr-tRNA(Tyr) deacylase K07560 - - 0.00000000000000000000000000000000000000000000000000000000002632 209.0
SHD2_k127_7876060_39 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000000000000000000000000000000000001562 206.0
SHD2_k127_7876060_4 TonB-dependent Receptor Plug Domain K02014,K16092 - - 3.469e-240 763.0
SHD2_k127_7876060_40 - - - - 0.000000000000000000000000000000000000000000000000000004889 195.0
SHD2_k127_7876060_41 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000001343 188.0
SHD2_k127_7876060_42 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000002524 173.0
SHD2_k127_7876060_43 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000000000007916 145.0
SHD2_k127_7876060_44 response to heat K07090 - - 0.0000000000000000000000000000000000009586 142.0
SHD2_k127_7876060_45 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000009281 130.0
SHD2_k127_7876060_46 chaperone-mediated protein folding - - - 0.0000000000000000000000000009563 120.0
SHD2_k127_7876060_47 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000001082 116.0
SHD2_k127_7876060_48 exo-alpha-(2->6)-sialidase activity K01406 - 3.4.24.40 0.0000000000000000000000000317 124.0
SHD2_k127_7876060_49 membrane protein (DUF2306) - - - 0.000000000000000000000007626 111.0
SHD2_k127_7876060_5 peptidase K01415,K07386 - 3.4.24.71 2.455e-236 749.0
SHD2_k127_7876060_50 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000008179 112.0
SHD2_k127_7876060_51 hyperosmotic response K04065 - - 0.0000000000000000000009918 107.0
SHD2_k127_7876060_52 Thioredoxin-like - - - 0.000000000000000000001059 103.0
SHD2_k127_7876060_53 OsmC-like protein K04063 - - 0.000000000000003027 81.0
SHD2_k127_7876060_55 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000001666 78.0
SHD2_k127_7876060_56 lysine biosynthetic process via aminoadipic acid - - - 0.0000005564 55.0
SHD2_k127_7876060_57 antisigma factor binding K04749,K05946,K06378 - 2.4.1.187 0.0000008413 57.0
SHD2_k127_7876060_58 Type IV pilus biogenesis stability protein PilW - - - 0.0000008761 60.0
SHD2_k127_7876060_6 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 6.7e-224 707.0
SHD2_k127_7876060_7 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 1.103e-218 689.0
SHD2_k127_7876060_8 Amidohydrolase family - - - 8.035e-216 677.0
SHD2_k127_7876060_9 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 4.385e-215 676.0
SHD2_k127_7919753_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0 1247.0
SHD2_k127_7919753_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 607.0
SHD2_k127_7919753_2 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 315.0
SHD2_k127_7919753_3 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000000000000000000000005954 229.0
SHD2_k127_7919753_4 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000009509 189.0
SHD2_k127_7919753_5 - - - - 0.000000000000000000000000000000000000000000000000005814 193.0
SHD2_k127_7919753_6 - - - - 0.000000000000000000000000003637 123.0
SHD2_k127_7919753_7 YXWGXW repeat (2 copies) - - - 0.00000000000000000000002393 102.0
SHD2_k127_7919753_9 CoA binding domain - - - 0.0000001373 56.0
SHD2_k127_8001082_0 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.0 1043.0
SHD2_k127_8001082_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 4.823e-268 850.0
SHD2_k127_8001082_10 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000000000000000000004717 235.0
SHD2_k127_8001082_11 - - - - 0.00000000000000000000000000000000000000000000000001871 185.0
SHD2_k127_8001082_12 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000002439 178.0
SHD2_k127_8001082_13 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000000009455 151.0
SHD2_k127_8001082_14 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000001513 153.0
SHD2_k127_8001082_15 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000001697 146.0
SHD2_k127_8001082_16 Recombinase - - - 0.0000004663 51.0
SHD2_k127_8001082_2 Rhodanese-like domain K01069 - 3.1.2.6 4.965e-236 736.0
SHD2_k127_8001082_3 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 448.0
SHD2_k127_8001082_4 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 445.0
SHD2_k127_8001082_5 L-seryl-tRNASec selenium transferase activity K01042 GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 400.0
SHD2_k127_8001082_6 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 345.0
SHD2_k127_8001082_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 351.0
SHD2_k127_8001082_8 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 323.0
SHD2_k127_8001082_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001224 281.0
SHD2_k127_802732_0 Aminotransferase, class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000906 506.0
SHD2_k127_802732_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 484.0
SHD2_k127_802732_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 287.0
SHD2_k127_8068747_0 Acetyl-CoA hydrolase/transferase N-terminal domain K01067 - 3.1.2.1 3.878e-265 819.0
SHD2_k127_8068747_1 alpha beta alpha domain I - - - 1.058e-208 657.0
SHD2_k127_8068747_10 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000583 226.0
SHD2_k127_8068747_11 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000006669 203.0
SHD2_k127_8068747_12 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000000000000000003264 158.0
SHD2_k127_8068747_2 PFAM Aminotransferase, class I K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008683 573.0
SHD2_k127_8068747_3 mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 523.0
SHD2_k127_8068747_4 Phosphomannose isomerase type I K01809 - 5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 421.0
SHD2_k127_8068747_5 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005679 432.0
SHD2_k127_8068747_6 Peptidase M48 K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 411.0
SHD2_k127_8068747_7 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 335.0
SHD2_k127_8068747_8 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009163 320.0
SHD2_k127_8068747_9 OmpA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000011 296.0
SHD2_k127_8119065_0 Peptide methionine sulfoxide reductase K07304,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000002185 243.0
SHD2_k127_8119065_1 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000006668 122.0
SHD2_k127_8253439_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 388.0
SHD2_k127_8253439_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 395.0
SHD2_k127_8253439_2 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 295.0
SHD2_k127_8253439_3 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001423 278.0
SHD2_k127_8253439_4 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000004207 258.0
SHD2_k127_8253439_5 - - - - 0.000000000000000000000000000000000000000000000000000000678 198.0
SHD2_k127_8253439_7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000004743 132.0
SHD2_k127_826886_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 344.0
SHD2_k127_826886_1 Acetyltransferase (GNAT) domain - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 - 0.000000000000000000000000000000000000000000003148 170.0
SHD2_k127_8282765_0 Glycosyl hydrolases family 2 K01192 - 3.2.1.25 1.277e-206 656.0
SHD2_k127_8286671_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 4.609e-234 728.0
SHD2_k127_8286671_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 450.0
SHD2_k127_8286671_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 344.0
SHD2_k127_8286671_3 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000051 78.0
SHD2_k127_8286671_4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000002694 64.0
SHD2_k127_8286671_5 Beta-lactamase - - - 0.0008731 44.0
SHD2_k127_829735_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2528.0
SHD2_k127_829735_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 389.0
SHD2_k127_829735_2 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000737 343.0
SHD2_k127_829735_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007207 241.0
SHD2_k127_829735_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000004881 206.0
SHD2_k127_829735_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000000000000000006633 190.0
SHD2_k127_829735_6 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000000000000000001468 94.0
SHD2_k127_829735_7 Ribosomal protein L33 K02913 - - 0.00000000000000000002784 90.0
SHD2_k127_829735_8 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000305 75.0
SHD2_k127_8333213_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000326 240.0
SHD2_k127_8333213_1 Probable zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000000000000006154 190.0
SHD2_k127_8333213_2 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000000000000000001968 112.0
SHD2_k127_8333213_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00001663 48.0
SHD2_k127_8334446_0 transposase K07481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 421.0
SHD2_k127_8411960_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 6.232e-286 881.0
SHD2_k127_8411960_1 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008098 442.0
SHD2_k127_8411960_2 cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 403.0
SHD2_k127_8411960_3 PFAM Cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 323.0
SHD2_k127_8411960_4 PFAM Cytochrome c assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 289.0
SHD2_k127_8411960_5 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004286 265.0
SHD2_k127_8411960_6 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000001654 175.0
SHD2_k127_8411960_7 Protein of unknown function (DUF1442) - - - 0.000000000000000000000000000003437 127.0
SHD2_k127_853576_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 8.636e-245 773.0
SHD2_k127_853576_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 8.634e-208 657.0
SHD2_k127_853576_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 393.0
SHD2_k127_853576_11 Belongs to the 'phage' integrase family. XerC subfamily K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 383.0
SHD2_k127_853576_12 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 311.0
SHD2_k127_853576_13 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 302.0
SHD2_k127_853576_14 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001346 278.0
SHD2_k127_853576_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001023 248.0
SHD2_k127_853576_16 - - - - 0.00000000000000000000000000000000000000000000000000000000000000631 219.0
SHD2_k127_853576_17 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000001094 190.0
SHD2_k127_853576_18 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000007256 190.0
SHD2_k127_853576_19 Pyridoxamine 5'-phosphate oxidase like - - - 0.000000000000000000000000000000000000000000000000005826 192.0
SHD2_k127_853576_2 Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family - - - 6.781e-198 632.0
SHD2_k127_853576_20 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000004248 148.0
SHD2_k127_853576_21 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000005281 141.0
SHD2_k127_853576_22 - - - - 0.000000000000000000000000000000008297 135.0
SHD2_k127_853576_23 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.00000000000000000000000000002192 123.0
SHD2_k127_853576_24 - - - - 0.00000000000000000000000000009331 127.0
SHD2_k127_853576_25 Putative Ig domain - - - 0.0000000000006662 78.0
SHD2_k127_853576_26 Sigma-54 interaction domain - - - 0.00004585 53.0
SHD2_k127_853576_3 Domain of unknown function (DUF3488) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 603.0
SHD2_k127_853576_4 Inorganic ion transport and metabolism K03319 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 581.0
SHD2_k127_853576_5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 554.0
SHD2_k127_853576_6 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 451.0
SHD2_k127_853576_7 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007573 448.0
SHD2_k127_853576_8 Multicopper oxidase K00368,K22348 - 1.16.3.3,1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 427.0
SHD2_k127_853576_9 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 414.0
SHD2_k127_86203_0 cellulose binding - - - 0.0 1318.0
SHD2_k127_86203_1 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0 1129.0
SHD2_k127_86203_10 MmgE/PrpD family K01720 - 4.2.1.79 6.229e-211 664.0
SHD2_k127_86203_11 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 3.788e-207 650.0
SHD2_k127_86203_12 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007042 558.0
SHD2_k127_86203_13 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 534.0
SHD2_k127_86203_14 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 527.0
SHD2_k127_86203_15 Polysaccharide biosynthesis protein K17947 - 5.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 524.0
SHD2_k127_86203_16 Zinc-binding dehydrogenase K12957,K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 520.0
SHD2_k127_86203_17 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 521.0
SHD2_k127_86203_18 Glycosyl hydrolase catalytic core - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 512.0
SHD2_k127_86203_19 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000439 516.0
SHD2_k127_86203_2 Peptidase family M13 K01415,K07386 - 3.4.24.71 2.203e-311 969.0
SHD2_k127_86203_20 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 479.0
SHD2_k127_86203_21 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 477.0
SHD2_k127_86203_22 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 427.0
SHD2_k127_86203_23 Protein of unknown function (DUF1698) K15257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 411.0
SHD2_k127_86203_24 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 372.0
SHD2_k127_86203_25 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 341.0
SHD2_k127_86203_26 mRNA catabolic process K06950,K09163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001136 277.0
SHD2_k127_86203_27 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002416 257.0
SHD2_k127_86203_28 Putative zinc- or iron-chelating domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005264 243.0
SHD2_k127_86203_29 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000009814 240.0
SHD2_k127_86203_3 3-isopropylmalate dehydratase activity K01703,K01704,K01705 - 4.2.1.33,4.2.1.35,4.2.1.36 4.401e-285 890.0
SHD2_k127_86203_30 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000001929 239.0
SHD2_k127_86203_31 Pfam Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000001615 229.0
SHD2_k127_86203_32 DoxX K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000000000000002639 213.0
SHD2_k127_86203_33 Nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000000000000001096 204.0
SHD2_k127_86203_34 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000002354 207.0
SHD2_k127_86203_35 Membrane protein implicated in regulation of membrane protease activity - - - 0.00000000000000000000000000000000000000000000000005268 187.0
SHD2_k127_86203_36 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.0000000000000000000000000000000000000000000001518 172.0
SHD2_k127_86203_37 - - - - 0.00000000000000000000000000000000001244 143.0
SHD2_k127_86203_38 PFAM Iron sulphur-containing domain, CDGSH-type - - - 0.0000000000000000000000000000000003074 134.0
SHD2_k127_86203_39 Tfp pilus assembly protein FimV - - - 0.0000000000000000000000000000362 125.0
SHD2_k127_86203_4 Domain of unknown function (DUF5117) - - - 3.07e-279 882.0
SHD2_k127_86203_40 - - - - 0.00000000000000000000000002955 112.0
SHD2_k127_86203_41 - - - - 0.00000000000000000000008948 102.0
SHD2_k127_86203_42 aminotransferase class I and II K00375 - - 0.000000000000000009766 86.0
SHD2_k127_86203_43 - - - - 0.0000000000000000124 90.0
SHD2_k127_86203_44 - - - - 0.000000000003181 67.0
SHD2_k127_86203_45 -acetyltransferase - - - 0.000000000504 67.0
SHD2_k127_86203_48 - - - - 0.0000001335 63.0
SHD2_k127_86203_49 PAS fold - - - 0.00002552 51.0
SHD2_k127_86203_5 citrate CoA-transferase activity K01643 - 2.8.3.10 1.008e-264 824.0
SHD2_k127_86203_51 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0004192 53.0
SHD2_k127_86203_52 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0005538 52.0
SHD2_k127_86203_6 Bacterial regulatory protein, Fis family K07713 - - 2.834e-240 751.0
SHD2_k127_86203_7 PAS domain - - - 4.672e-239 754.0
SHD2_k127_86203_8 Flotillin K07192 - - 5.498e-222 698.0
SHD2_k127_86203_9 Sigma-54 interaction domain - - - 2.228e-218 687.0
SHD2_k127_91013_0 Belongs to the ClpA ClpB family K03696 - - 0.0 1173.0
SHD2_k127_91013_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 286.0
SHD2_k127_997333_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1371.0
SHD2_k127_997333_1 RNA binding K06959 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 496.0
SHD2_k127_997333_2 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 422.0
SHD2_k127_997333_3 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000007893 186.0
SHD2_k127_997333_4 isomerase activity K01821 - 5.3.2.6 0.00000000000000000000000000009019 117.0
SHD2_k127_997333_5 TonB dependent receptor - - - 0.00001536 55.0