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Overview

ID MAG03373
Name SHD2_bin.13
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Thermodesulfovibrionia
Order Thermodesulfovibrionales
Family UBA6898
Genus Sulfobium
Species
Assembly information
Completeness (%) 94.28
Contamination (%) 7.37
GC content (%) 51.0
N50 (bp) 12,314
Genome size (bp) 2,610,160

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2460

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1074676_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 8.101e-246 767.0
SHD2_k127_1074676_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 2.224e-237 752.0
SHD2_k127_1074676_10 - - - - 0.000000000000000000000001387 111.0
SHD2_k127_1074676_11 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000001106 95.0
SHD2_k127_1074676_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.458e-231 724.0
SHD2_k127_1074676_3 cytochrome C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 383.0
SHD2_k127_1074676_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 358.0
SHD2_k127_1074676_5 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 313.0
SHD2_k127_1074676_6 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005181 313.0
SHD2_k127_1074676_7 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000007417 271.0
SHD2_k127_1074676_8 - - - - 0.0000000000000000000000000000000000000000000721 183.0
SHD2_k127_1074676_9 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000275 118.0
SHD2_k127_109204_0 Elongation factor SelB, winged helix K03833 - - 4.076e-210 670.0
SHD2_k127_109204_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 529.0
SHD2_k127_109204_10 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000004188 179.0
SHD2_k127_109204_11 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000003605 160.0
SHD2_k127_109204_12 NTPase - - - 0.0000000000000000000000000000000000000001574 156.0
SHD2_k127_109204_13 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000002863 162.0
SHD2_k127_109204_15 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000003771 124.0
SHD2_k127_109204_16 peptidyl-tyrosine sulfation - - - 0.000000001088 71.0
SHD2_k127_109204_2 Ecdysteroid kinase K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 466.0
SHD2_k127_109204_3 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 447.0
SHD2_k127_109204_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 441.0
SHD2_k127_109204_5 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 338.0
SHD2_k127_109204_6 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 327.0
SHD2_k127_109204_7 PFAM CobQ CobB MinD ParA nucleotide binding domain K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 317.0
SHD2_k127_109204_8 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 286.0
SHD2_k127_109204_9 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000009045 179.0
SHD2_k127_1095735_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003863 295.0
SHD2_k127_1095735_1 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000001005 233.0
SHD2_k127_1098664_0 L,D-transpeptidase catalytic domain K16291 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009518 606.0
SHD2_k127_1098664_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 603.0
SHD2_k127_1098664_10 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 318.0
SHD2_k127_1098664_11 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 291.0
SHD2_k127_1098664_12 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
SHD2_k127_1098664_13 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000000000000000000000000000000001938 185.0
SHD2_k127_1098664_14 bacterial (prokaryotic) histone like domain K05788 - - 0.00000000000000000000000001732 111.0
SHD2_k127_1098664_15 Alanine-zipper, major outer membrane lipoprotein - - - 0.0000000000000003164 82.0
SHD2_k127_1098664_2 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 503.0
SHD2_k127_1098664_3 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 476.0
SHD2_k127_1098664_4 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 436.0
SHD2_k127_1098664_5 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00210,K00220,K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 1.3.1.12,1.3.1.43,2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 441.0
SHD2_k127_1098664_6 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 433.0
SHD2_k127_1098664_7 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 432.0
SHD2_k127_1098664_8 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 414.0
SHD2_k127_1098664_9 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003074 321.0
SHD2_k127_1099933_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.693e-204 653.0
SHD2_k127_1099933_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 610.0
SHD2_k127_1099933_2 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000000002575 207.0
SHD2_k127_1099933_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000004617 186.0
SHD2_k127_1099933_4 - - - - 0.00000000000000000000000001247 113.0
SHD2_k127_1099933_5 His Kinase A (phosphoacceptor) domain K07708 - 2.7.13.3 0.000000000001463 72.0
SHD2_k127_1107077_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 7.795e-198 623.0
SHD2_k127_1107077_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 453.0
SHD2_k127_1107077_10 proteolysis K03665 - - 0.000000000000000000000000000001638 126.0
SHD2_k127_1107077_11 - - - - 0.0000000000000001028 79.0
SHD2_k127_1107077_12 - - - - 0.00000000000001724 74.0
SHD2_k127_1107077_14 - - - - 0.000002525 49.0
SHD2_k127_1107077_15 - - - - 0.00001719 46.0
SHD2_k127_1107077_2 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 340.0
SHD2_k127_1107077_3 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000007251 261.0
SHD2_k127_1107077_4 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000001248 248.0
SHD2_k127_1107077_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000393 235.0
SHD2_k127_1107077_6 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000002478 233.0
SHD2_k127_1107077_7 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000001513 174.0
SHD2_k127_1107077_8 Universal stress protein family - - - 0.0000000000000000000000000000000000000005794 156.0
SHD2_k127_1107077_9 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03832 - - 0.00000000000000000000000000000000000004892 154.0
SHD2_k127_111749_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1085.0
SHD2_k127_111749_1 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 4.768e-307 950.0
SHD2_k127_111749_10 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000001144 192.0
SHD2_k127_111749_12 - - - - 0.0000000000000009668 79.0
SHD2_k127_111749_13 - - - - 0.00000000004425 67.0
SHD2_k127_111749_14 Positive regulator of sigma(E), RseC MucC K03803 - - 0.00005735 51.0
SHD2_k127_111749_15 diguanylate cyclase - - - 0.0003129 47.0
SHD2_k127_111749_2 Elongation factor G, domain IV K02355 - - 1.373e-296 924.0
SHD2_k127_111749_3 PFAM ferredoxin-dependent glutamate synthase - - - 7.367e-254 788.0
SHD2_k127_111749_4 Glucose-1-phosphate thymidylyltransferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 434.0
SHD2_k127_111749_5 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 425.0
SHD2_k127_111749_6 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 388.0
SHD2_k127_111749_7 PFAM Glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 293.0
SHD2_k127_111749_8 Male sterility protein K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000961 280.0
SHD2_k127_111749_9 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006668 282.0
SHD2_k127_1120433_0 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 421.0
SHD2_k127_1120433_1 Domain of unknown function (DUF4126) - - - 0.00000000000000000000000000000000000000000000000000002043 194.0
SHD2_k127_1120433_10 acetyltransferase K00661 - 2.3.1.79 0.0000002059 61.0
SHD2_k127_1120433_11 Protein of unknown function DUF116 K09729 - - 0.000159 53.0
SHD2_k127_1120433_2 - - - - 0.00000000000000000000000000000000000000000000002695 175.0
SHD2_k127_1120433_3 MarC family integral membrane protein - - - 0.0000000000000000000000000000000000000000000331 167.0
SHD2_k127_1120433_4 protein with SCP PR1 domains - - - 0.000000000000000000000000000000000000001067 158.0
SHD2_k127_1120433_5 Predicted membrane protein (DUF2127) - - - 0.00000000000000000000000000000000001566 138.0
SHD2_k127_1120433_6 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000001244 145.0
SHD2_k127_1120433_7 PFAM Transglycosylase-associated protein - - - 0.00000000000000000000000000001327 119.0
SHD2_k127_1120433_9 - - - - 0.0000000000001 74.0
SHD2_k127_1131964_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 395.0
SHD2_k127_1131964_1 - K07112 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000001084 168.0
SHD2_k127_1211681_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K13924 - 2.1.1.80,3.1.1.61 4.827e-287 934.0
SHD2_k127_1211681_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003516 282.0
SHD2_k127_1211681_2 part of a sulfur-relay system K11179 - - 0.000000000000000000000000000000000003878 140.0
SHD2_k127_1211681_3 glycosyltransferase 36 associated K00702,K13688 - 2.4.1.20 0.00000000000000000000000000000000001255 139.0
SHD2_k127_1217325_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.5e-323 1002.0
SHD2_k127_1217325_1 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009477 550.0
SHD2_k127_1217325_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 437.0
SHD2_k127_1217325_3 Methyl-viologen-reducing hydrogenase, delta subunit K16886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 422.0
SHD2_k127_1217325_4 nitrate reductase activity K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 398.0
SHD2_k127_1217325_5 pfkB family carbohydrate kinase K00847,K00852 - 2.7.1.15,2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 330.0
SHD2_k127_1217325_6 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 304.0
SHD2_k127_1217325_7 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004861 268.0
SHD2_k127_1217325_8 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000036 110.0
SHD2_k127_1217325_9 protein secretion K03116,K03117 - - 0.000000001775 61.0
SHD2_k127_1218955_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 522.0
SHD2_k127_1218955_1 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 415.0
SHD2_k127_1218955_2 Glycosyltransferase, group 4 family K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000008491 245.0
SHD2_k127_1218955_4 Domain of unknown function (DUF296) - - - 0.0000000000005533 69.0
SHD2_k127_1248868_0 Domain of unknown function (DUF4070) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 583.0
SHD2_k127_1248868_1 Domain of unknown function (DUF3943) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 513.0
SHD2_k127_1248868_2 - - - - 0.0000000004744 66.0
SHD2_k127_1258707_0 PD-(D/E)XK nuclease superfamily - - - 4.383e-241 779.0
SHD2_k127_1258707_1 Belongs to the helicase family. UvrD subfamily - - - 1.822e-227 736.0
SHD2_k127_1258707_10 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001132 278.0
SHD2_k127_1258707_11 dUTP biosynthetic process K01494 GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000002089 259.0
SHD2_k127_1258707_12 transcriptional regulator - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000005009 222.0
SHD2_k127_1258707_13 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000008659 220.0
SHD2_k127_1258707_14 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000007334 140.0
SHD2_k127_1258707_15 carbon dioxide binding K04653 - - 0.00000000000000004121 86.0
SHD2_k127_1258707_16 PFAM Tetratricopeptide repeat - - - 0.00000165 57.0
SHD2_k127_1258707_2 C-terminal domain of tail specific protease (DUF3340) K03797 - 3.4.21.102 1.421e-226 724.0
SHD2_k127_1258707_3 ABC-type antimicrobial peptide transport system, permease component K02004 - - 1.715e-199 627.0
SHD2_k127_1258707_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 454.0
SHD2_k127_1258707_5 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 449.0
SHD2_k127_1258707_6 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008711 407.0
SHD2_k127_1258707_7 HlyD membrane-fusion protein of T1SS K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 379.0
SHD2_k127_1258707_8 Sugar (and other) transporter K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 324.0
SHD2_k127_1258707_9 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 311.0
SHD2_k127_1258729_0 Pyridoxal-phosphate dependent enzyme K06001 - 4.2.1.20 4.082e-225 704.0
SHD2_k127_1258729_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 387.0
SHD2_k127_1258729_10 - - - - 0.0000000000000000000000000004854 119.0
SHD2_k127_1258729_11 Protein of unknown function DUF134 - - - 0.000000000000000000000000011 111.0
SHD2_k127_1258729_12 Antioxidant, AhpC TSA family - - - 0.0000000001513 63.0
SHD2_k127_1258729_14 Thioredoxin-like - - - 0.0002688 47.0
SHD2_k127_1258729_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000433 245.0
SHD2_k127_1258729_3 ATP cone domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002501 241.0
SHD2_k127_1258729_4 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000001583 198.0
SHD2_k127_1258729_5 Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000000000000000001205 153.0
SHD2_k127_1258729_6 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000004988 144.0
SHD2_k127_1258729_7 Protein of unknown function (DUF3617) - - - 0.000000000000000000000000000000000007821 140.0
SHD2_k127_1258729_8 Arginine-tRNA-protein transferase, N terminus K21420 - 2.3.2.29 0.00000000000000000000000000000000001116 145.0
SHD2_k127_1258729_9 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K13531 - 2.1.1.63 0.00000000000000000000000000000005369 131.0
SHD2_k127_1276085_0 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 4.611e-206 649.0
SHD2_k127_1276085_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 577.0
SHD2_k127_1276085_2 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 468.0
SHD2_k127_1276085_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 346.0
SHD2_k127_1276085_4 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001311 241.0
SHD2_k127_1276085_5 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000004902 207.0
SHD2_k127_1276085_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000007538 192.0
SHD2_k127_1276085_7 TIGRFAM transcriptional regulator, Rrf2 family - - - 0.00000000000000000000000000000000000000000001747 165.0
SHD2_k127_1276085_8 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000001909 124.0
SHD2_k127_1276085_9 AhpC/TSA family K03386 - 1.11.1.15 0.000000000000002557 76.0
SHD2_k127_1287234_0 Nitrite and sulphite reductase 4Fe-4S K11181 - 1.8.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 551.0
SHD2_k127_1287234_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 522.0
SHD2_k127_1287234_2 part of a sulfur-relay system K11179 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - 0.000000000000000000000000000000000000000000000000000005288 191.0
SHD2_k127_1287234_3 HEAT-like repeat - - - 0.00000000000000000000004247 108.0
SHD2_k127_1287234_4 lyase activity - - - 0.000000000000000001437 89.0
SHD2_k127_1287234_5 Nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 0.00000000000274 68.0
SHD2_k127_1292237_0 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 491.0
SHD2_k127_1292237_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 332.0
SHD2_k127_1292237_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007859 299.0
SHD2_k127_1292237_3 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000008127 197.0
SHD2_k127_1292237_4 protein tyrosine phosphatase activity K01104,K19302 - 3.1.3.48,3.6.1.27 0.000000000000000000000000000000000000000000000000003906 189.0
SHD2_k127_1292237_5 glycogen (starch) synthase activity - - - 0.000000000000000000000000000000000000000000000000005958 195.0
SHD2_k127_1292237_6 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000008376 173.0
SHD2_k127_1292237_7 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000001539 160.0
SHD2_k127_1292237_8 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000006024 98.0
SHD2_k127_1292237_9 GlcNAc-PI de-N-acetylase K01463 - - 0.000000000000000000002128 103.0
SHD2_k127_1293204_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 9.327e-209 657.0
SHD2_k127_1293204_1 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 4.292e-196 616.0
SHD2_k127_1293204_10 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000001469 174.0
SHD2_k127_1293204_11 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000003767 173.0
SHD2_k127_1293204_12 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000001475 145.0
SHD2_k127_1293204_13 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000001864 125.0
SHD2_k127_1293204_14 Belongs to the UPF0296 family K09777 - - 0.00000000000000000000000002723 111.0
SHD2_k127_1293204_15 Roadblock/LC7 domain - - - 0.0000000000000000002808 92.0
SHD2_k127_1293204_16 belongs to the thioredoxin family K14949,K20543 - 2.7.11.1 0.0000000000000000005237 99.0
SHD2_k127_1293204_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 497.0
SHD2_k127_1293204_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004728 383.0
SHD2_k127_1293204_4 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 312.0
SHD2_k127_1293204_5 Metallopeptidase family M24 K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004785 278.0
SHD2_k127_1293204_6 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000001628 245.0
SHD2_k127_1293204_7 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000001595 219.0
SHD2_k127_1293204_8 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000009917 214.0
SHD2_k127_1293204_9 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000001373 171.0
SHD2_k127_1368253_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 6.495e-202 634.0
SHD2_k127_1368253_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 5.295e-200 632.0
SHD2_k127_1368253_10 YtxH-like protein - - - 0.0000000000000000000000001584 109.0
SHD2_k127_1368253_11 SMART Rhodanese domain protein - - - 0.0000000000000000000000005871 106.0
SHD2_k127_1368253_12 peptidyl-tyrosine sulfation - - - 0.00000000009095 71.0
SHD2_k127_1368253_14 - - - - 0.0000743 53.0
SHD2_k127_1368253_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 434.0
SHD2_k127_1368253_3 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 421.0
SHD2_k127_1368253_4 S-methyl-5-thioadenosine phosphorylase activity K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004645,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0010033,GO:0016053,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0017061,GO:0017144,GO:0019221,GO:0019509,GO:0019752,GO:0023052,GO:0032259,GO:0034097,GO:0034641,GO:0035722,GO:0042221,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070671,GO:0070887,GO:0071265,GO:0071267,GO:0071310,GO:0071345,GO:0071349,GO:0071704,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 330.0
SHD2_k127_1368253_5 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 317.0
SHD2_k127_1368253_6 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 298.0
SHD2_k127_1368253_7 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 300.0
SHD2_k127_1368253_8 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000004001 193.0
SHD2_k127_1368253_9 nickel cation binding K04651,K19640 - - 0.00000000000000000000000000000006919 128.0
SHD2_k127_138062_0 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 2.563e-276 858.0
SHD2_k127_138062_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 4.359e-215 676.0
SHD2_k127_138062_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007723 522.0
SHD2_k127_138062_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 360.0
SHD2_k127_138062_4 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000005447 211.0
SHD2_k127_138062_5 Protein of unknown function (DUF1456) - - - 0.0000000000000000000000000000002268 123.0
SHD2_k127_138062_6 - - - - 0.000000000000000000000000001502 124.0
SHD2_k127_138062_7 Thioredoxin-like - - - 0.0002231 46.0
SHD2_k127_1386907_0 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 541.0
SHD2_k127_1386907_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 460.0
SHD2_k127_1386907_2 - - - - 0.00000000000000000000000000000000000000000000000000004498 192.0
SHD2_k127_1386907_3 HD domain K07814 - - 0.0000000000000000002943 98.0
SHD2_k127_1386907_4 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000003646 86.0
SHD2_k127_1401900_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.175e-264 832.0
SHD2_k127_1401900_1 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 447.0
SHD2_k127_1401900_2 Bacterial type II and III secretion system protein K02453,K03219 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007532 303.0
SHD2_k127_1401900_3 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000001317 229.0
SHD2_k127_1401900_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000003964 220.0
SHD2_k127_1401900_5 group 2 family protein - - - 0.000000000000000000000000000000000000000000000000000000000005149 215.0
SHD2_k127_1401900_6 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000004069 209.0
SHD2_k127_1401900_7 - - - - 0.0000000000000000000002272 111.0
SHD2_k127_1401900_8 Uncharacterized conserved protein (DUF2304) - - - 0.00000000008566 67.0
SHD2_k127_1401900_9 - - - - 0.0000001297 59.0
SHD2_k127_1411451_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1165.0
SHD2_k127_1411451_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 460.0
SHD2_k127_1411451_10 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000002264 102.0
SHD2_k127_1411451_11 DsrE/DsrF-like family - - - 0.00000001203 56.0
SHD2_k127_1411451_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 443.0
SHD2_k127_1411451_3 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 370.0
SHD2_k127_1411451_4 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 352.0
SHD2_k127_1411451_5 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 316.0
SHD2_k127_1411451_6 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005373 297.0
SHD2_k127_1411451_7 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000658 229.0
SHD2_k127_1411451_8 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000003381 173.0
SHD2_k127_1411451_9 Stage II sporulation protein M - - - 0.0000000000000000000000000004019 121.0
SHD2_k127_1413089_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 1.618e-194 635.0
SHD2_k127_1413089_1 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 399.0
SHD2_k127_1413089_2 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000003917 166.0
SHD2_k127_142945_0 Protein of unknown function, DUF255 K06888 - - 3.98e-254 799.0
SHD2_k127_142945_1 Domain in cystathionine beta-synthase and other proteins. K07182 - - 8.356e-198 635.0
SHD2_k127_142945_10 methyltransferase activity - - - 0.00000000000000000000000000000000000000005113 158.0
SHD2_k127_142945_13 Response regulator receiver - - - 0.000000000000000000000000004455 115.0
SHD2_k127_142945_14 Predicted membrane protein (DUF2318) - - - 0.0000000000000000002048 93.0
SHD2_k127_142945_15 - - - - 0.00000000000001646 75.0
SHD2_k127_142945_16 peroxiredoxin activity - - - 0.000007146 49.0
SHD2_k127_142945_2 PFAM natural resistance-associated macrophage protein K03322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 519.0
SHD2_k127_142945_3 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 444.0
SHD2_k127_142945_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 361.0
SHD2_k127_142945_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001877 282.0
SHD2_k127_142945_6 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003758 284.0
SHD2_k127_142945_7 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000003025 238.0
SHD2_k127_142945_8 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000000000000002003 223.0
SHD2_k127_142945_9 PFAM Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.00000000000000000000000000000000000000000000000000000001365 211.0
SHD2_k127_1434323_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.186e-198 624.0
SHD2_k127_1434323_1 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 359.0
SHD2_k127_1434323_10 - - - - 0.0000000000000000006593 89.0
SHD2_k127_1434323_11 CYTH K05873 - 4.6.1.1 0.0000000002135 68.0
SHD2_k127_1434323_12 PFAM Rhodanese domain protein - - - 0.00000001873 62.0
SHD2_k127_1434323_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 312.0
SHD2_k127_1434323_3 Fumarate hydratase (Fumerase) K01676 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001685 285.0
SHD2_k127_1434323_4 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000003854 241.0
SHD2_k127_1434323_5 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000008292 197.0
SHD2_k127_1434323_6 AMP binding - - - 0.00000000000000000000000000000000000000004116 157.0
SHD2_k127_1434323_7 AMP binding - - - 0.0000000000000000000000000000000000000006048 160.0
SHD2_k127_1434323_8 Transcriptional regulator - - - 0.000000000000000000000000000000002232 137.0
SHD2_k127_1434323_9 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000002822 128.0
SHD2_k127_1477226_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006016 501.0
SHD2_k127_1477226_1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 389.0
SHD2_k127_1477226_2 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 376.0
SHD2_k127_1477226_3 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 299.0
SHD2_k127_1477226_4 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000009754 237.0
SHD2_k127_1477226_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000002955 214.0
SHD2_k127_1499424_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.204e-286 895.0
SHD2_k127_1499424_1 Dehydratase family K01687 - 4.2.1.9 1.404e-264 826.0
SHD2_k127_1499424_2 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 456.0
SHD2_k127_1499424_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000004081 257.0
SHD2_k127_1499424_4 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002746 247.0
SHD2_k127_1499424_5 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000003161 184.0
SHD2_k127_1499424_6 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000858 129.0
SHD2_k127_1499424_7 Protein of unknown function (DUF465) K09794 - - 0.0000000000000000008201 88.0
SHD2_k127_1520871_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 2.55e-208 653.0
SHD2_k127_1520871_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 472.0
SHD2_k127_1520871_2 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 330.0
SHD2_k127_1520871_3 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005944 320.0
SHD2_k127_1520871_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000002671 109.0
SHD2_k127_1522128_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1160.0
SHD2_k127_1522128_1 K transport systems K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 381.0
SHD2_k127_1522128_2 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 321.0
SHD2_k127_1522128_3 LemA family K03744 - - 0.0000002624 57.0
SHD2_k127_1524210_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003577 437.0
SHD2_k127_1524210_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 349.0
SHD2_k127_1524210_2 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 340.0
SHD2_k127_1524210_3 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 293.0
SHD2_k127_1524210_4 Tetratricopeptide repeat K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000004207 238.0
SHD2_k127_1524210_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000001192 199.0
SHD2_k127_1524210_6 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000002787 175.0
SHD2_k127_154858_0 phosphoglucosamine mutase activity K01835,K01840 - 5.4.2.2,5.4.2.8 2.006e-226 713.0
SHD2_k127_154858_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 1.057e-203 636.0
SHD2_k127_154858_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 592.0
SHD2_k127_154858_3 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 592.0
SHD2_k127_154858_4 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 598.0
SHD2_k127_154858_5 S-adenosylhomocysteine deaminase activity K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 478.0
SHD2_k127_154858_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000005683 233.0
SHD2_k127_154858_7 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000001629 141.0
SHD2_k127_154858_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000002121 80.0
SHD2_k127_154858_9 Transposase K07483 - - 0.0000000813 59.0
SHD2_k127_155197_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1162.0
SHD2_k127_155197_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 572.0
SHD2_k127_155197_2 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 479.0
SHD2_k127_155197_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 439.0
SHD2_k127_155197_4 PFAM PfkB K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 386.0
SHD2_k127_155197_5 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003209 271.0
SHD2_k127_155197_6 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.00000000000000000000000000000000000000000000000000001743 196.0
SHD2_k127_155197_7 COG3209 Rhs family protein - - - 0.000000000000000000000002015 111.0
SHD2_k127_155197_8 SMART Tetratricopeptide - - - 0.000000000000000000000004705 109.0
SHD2_k127_1596320_0 Alpha-glucan water dikinase K08244 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009266,GO:0009409,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009608,GO:0009610,GO:0009620,GO:0009628,GO:0009631,GO:0009941,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0031967,GO:0031975,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0050521,GO:0050896,GO:0051704,GO:0051707,GO:0071704,GO:1901575 2.7.9.4 3.361e-232 754.0
SHD2_k127_1596320_1 Phosphoglucan, water dikinase K15535 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019200,GO:0019538,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044275,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046777,GO:0046835,GO:0051752,GO:0071704,GO:1901564,GO:1901575 2.7.9.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 586.0
SHD2_k127_1596320_2 Alpha amylase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 544.0
SHD2_k127_1596320_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000441 282.0
SHD2_k127_1596320_4 Desulfoferrodoxin ferrous iron-binding K05919 - 1.15.1.2 0.00000000000000000000000000000000000000000000000000004319 189.0
SHD2_k127_1596320_5 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000006997 120.0
SHD2_k127_167813_0 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009478 501.0
SHD2_k127_167813_1 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 331.0
SHD2_k127_167813_2 PFAM Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 293.0
SHD2_k127_167813_3 COG3209 Rhs family protein - - - 0.00000000000007095 85.0
SHD2_k127_1753718_0 Ftsk_gamma K03466 - - 1.175e-204 659.0
SHD2_k127_1753718_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 1.055e-200 640.0
SHD2_k127_1753718_10 sigma factor antagonist activity K04757 - 2.7.11.1 0.0000000000002347 83.0
SHD2_k127_1753718_11 - - - - 0.000000000003841 79.0
SHD2_k127_1753718_12 PFAM Sulfate transporter antisigma-factor antagonist STAS - - - 0.0000000001872 66.0
SHD2_k127_1753718_2 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 510.0
SHD2_k127_1753718_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007552 387.0
SHD2_k127_1753718_4 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 370.0
SHD2_k127_1753718_5 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004844 274.0
SHD2_k127_1753718_6 HD domain - - - 0.0000000000000000000000000000000000000000000001091 183.0
SHD2_k127_1753718_7 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.00000000000000000000000000000000002674 145.0
SHD2_k127_1753718_8 domain, Protein K00703,K07082 - 2.4.1.21 0.0000000000000002133 84.0
SHD2_k127_1753718_9 4Fe-4S dicluster domain - - - 0.00000000000000287 76.0
SHD2_k127_176489_0 Glucodextranase, domain N K01178 - 3.2.1.3 2.618e-198 626.0
SHD2_k127_176489_1 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 486.0
SHD2_k127_176489_2 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008007 338.0
SHD2_k127_176489_3 Copper resistance protein CopZ K07213 - - 0.00002848 49.0
SHD2_k127_1790842_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 496.0
SHD2_k127_1790842_1 geranylgeranyl reductase activity K14266 - 1.14.19.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 388.0
SHD2_k127_1790842_2 Phosphoglucose isomerase K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000009769 173.0
SHD2_k127_1790842_3 Belongs to the HesB IscA family K15724 - - 0.0000000000000000000000000000001798 126.0
SHD2_k127_1790842_4 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000002202 111.0
SHD2_k127_1790842_5 - - - - 0.000000004486 61.0
SHD2_k127_1790842_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000324 60.0
SHD2_k127_1799621_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 361.0
SHD2_k127_1799621_1 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000001767 154.0
SHD2_k127_1799621_2 PFAM transglutaminase domain protein - - - 0.000000000000000000000000000000000001749 153.0
SHD2_k127_1799621_3 Domain of unknown function (DUF4382) - - - 0.0000000000000000002698 94.0
SHD2_k127_1799621_4 Cupin domain - - - 0.0000000000008409 68.0
SHD2_k127_1799621_5 Domain of unknown function (DUF4382) - - - 0.000025 48.0
SHD2_k127_1812317_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 324.0
SHD2_k127_1812317_1 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 285.0
SHD2_k127_1812317_2 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000002012 148.0
SHD2_k127_185311_0 Belongs to the sulfate adenylyltransferase family K00958,K13811 - 2.7.1.25,2.7.7.4 9.149e-205 643.0
SHD2_k127_185311_1 PFAM DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005754 281.0
SHD2_k127_185311_2 reductase, beta subunit K00395 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000005828 228.0
SHD2_k127_185311_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000004146 225.0
SHD2_k127_185311_4 reductase, alpha subunit K00394 - 1.8.99.2 0.000000000000000002036 85.0
SHD2_k127_185351_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 375.0
SHD2_k127_185351_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 374.0
SHD2_k127_185351_2 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001127 284.0
SHD2_k127_185351_3 Vitamin K epoxide reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000005504 244.0
SHD2_k127_185351_4 Protein of unknown function (DUF4019) - - - 0.0000000000000000000000000000000000005328 142.0
SHD2_k127_1885436_0 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 311.0
SHD2_k127_1885436_1 Protein of unknown function (DUF1460) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004744 254.0
SHD2_k127_1885436_2 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000001447 243.0
SHD2_k127_1885436_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000003681 200.0
SHD2_k127_1885436_4 - - - - 0.0000000000000000000000421 107.0
SHD2_k127_1885436_5 Bifunctional purine biosynthesis protein PurH K00602 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.2.3,3.5.4.10 0.0002916 46.0
SHD2_k127_2027656_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 610.0
SHD2_k127_2027656_1 PFAM SPFH domain Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 528.0
SHD2_k127_2027656_2 oxidoreductase activity K00316 - 1.5.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 532.0
SHD2_k127_2027656_3 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 462.0
SHD2_k127_2027656_4 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 433.0
SHD2_k127_2027656_5 Tetratricopeptide repeat - - - 0.000000000000000000000000001304 126.0
SHD2_k127_2027656_6 Domain of Unknown Function (DUF350) - - - 0.00000000004698 65.0
SHD2_k127_2121713_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 4.551e-255 799.0
SHD2_k127_2121713_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 425.0
SHD2_k127_2121713_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007816 417.0
SHD2_k127_2121713_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000001088 234.0
SHD2_k127_2121713_4 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000001578 208.0
SHD2_k127_2121713_5 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000006718 205.0
SHD2_k127_2121713_6 Signal transduction response regulator, receiver domain - - - 0.00000000000000000000000000000000000000000000000000008649 195.0
SHD2_k127_2121713_7 Two component regulator propeller - - - 0.000000000000000000000396 106.0
SHD2_k127_2121713_8 Bacterial regulatory protein, Fis family - - - 0.00002283 49.0
SHD2_k127_2121713_9 YceI-like domain - - - 0.00002705 49.0
SHD2_k127_2128530_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 1.556e-262 822.0
SHD2_k127_2128530_1 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001422 257.0
SHD2_k127_2146261_0 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 582.0
SHD2_k127_2146261_1 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 486.0
SHD2_k127_2146261_10 - K07112 - - 0.0000000000000000000000000000000000001988 146.0
SHD2_k127_2146261_11 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.0000000000000000000000000000000002521 132.0
SHD2_k127_2146261_12 TM2 domain - - - 0.0000000000000000000000000000000004388 135.0
SHD2_k127_2146261_13 Ribosomal protein L36 K02919 - - 0.0000000000000003869 78.0
SHD2_k127_2146261_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 362.0
SHD2_k127_2146261_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004264 281.0
SHD2_k127_2146261_4 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000004143 240.0
SHD2_k127_2146261_5 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000002213 207.0
SHD2_k127_2146261_6 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000002999 178.0
SHD2_k127_2146261_7 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.000000000000000000000000000000000000000000000009281 175.0
SHD2_k127_2146261_8 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K00406,K01011,K07112 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000006512 178.0
SHD2_k127_2146261_9 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000008471 162.0
SHD2_k127_2147225_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.316e-224 701.0
SHD2_k127_2147225_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000131 243.0
SHD2_k127_2147225_2 PFAM Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000008083 169.0
SHD2_k127_2147225_3 SWI complex, BAF60b domains - - - 0.00000000000000000000000000002471 119.0
SHD2_k127_2147225_4 Diguanylate cyclase - - - 0.0000000000006027 71.0
SHD2_k127_2147225_5 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.00000001055 57.0
SHD2_k127_2158753_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 2.924e-267 834.0
SHD2_k127_2158753_1 PFAM Prenyltransferase squalene oxidase K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 4.019e-241 763.0
SHD2_k127_2158753_10 YdjC-like protein - - - 0.0000000000000000000000000000000000000000000000000203 191.0
SHD2_k127_2158753_11 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000001005 143.0
SHD2_k127_2158753_12 MlaC protein K07323 - - 0.0000000000000000000000000000000002862 139.0
SHD2_k127_2158753_13 PFAM RNA recognition motif - - - 0.000000000000000000000003781 106.0
SHD2_k127_2158753_14 - - - - 0.000000000000000000211 95.0
SHD2_k127_2158753_15 EamA-like transporter family - - - 0.000000000000000000302 94.0
SHD2_k127_2158753_16 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000006062 78.0
SHD2_k127_2158753_17 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000001308 78.0
SHD2_k127_2158753_18 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0005305 48.0
SHD2_k127_2158753_2 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009481 566.0
SHD2_k127_2158753_3 TIGRFAM hopanoid biosynthesis associated RND transporter like protein HpnN K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 565.0
SHD2_k127_2158753_4 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 415.0
SHD2_k127_2158753_5 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 376.0
SHD2_k127_2158753_6 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008628 303.0
SHD2_k127_2158753_7 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000195 269.0
SHD2_k127_2158753_8 - - - - 0.000000000000000000000000000000000000000000000000000000000001714 221.0
SHD2_k127_2158753_9 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.00000000000000000000000000000000000000000000000001046 190.0
SHD2_k127_2159664_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 7.273e-319 990.0
SHD2_k127_2159664_1 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000001641 136.0
SHD2_k127_2159664_2 membrane transporter protein K07090 - - 0.000000000001583 68.0
SHD2_k127_2161301_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1240.0
SHD2_k127_2161301_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000361 268.0
SHD2_k127_2161301_2 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000001172 179.0
SHD2_k127_2182776_0 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 484.0
SHD2_k127_2182776_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 327.0
SHD2_k127_2182776_10 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000002826 124.0
SHD2_k127_2182776_12 Regulatory protein, FmdB family - - - 0.000000003321 59.0
SHD2_k127_2182776_13 Resolvase - - - 0.000000382 52.0
SHD2_k127_2182776_2 ABC transporter K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000007474 241.0
SHD2_k127_2182776_3 Belongs to the bacterial solute-binding protein 9 family K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000003645 228.0
SHD2_k127_2182776_4 ABC 3 transport family K09816,K09819 - - 0.000000000000000000000000000000000000000000000000000000001486 209.0
SHD2_k127_2182776_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000000000000924 196.0
SHD2_k127_2182776_6 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.000000000000000000000000000000000000000000000000001187 192.0
SHD2_k127_2182776_7 Domain of unknown function (DUF1992) - - - 0.0000000000000000000000000000000000000004659 152.0
SHD2_k127_2182776_8 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000001615 129.0
SHD2_k127_2182776_9 cheY-homologous receiver domain - - - 0.0000000000000000000000000000003943 134.0
SHD2_k127_2210300_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 449.0
SHD2_k127_2210300_1 MlaC protein K07323 - - 0.000000000000000000000000000000000000000000000000000000000000000209 226.0
SHD2_k127_2210300_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000076 224.0
SHD2_k127_2210300_3 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000008167 210.0
SHD2_k127_2210300_4 Virulence factor BrkB K07058 - - 0.000000000000000000000000002987 122.0
SHD2_k127_2210300_5 ABC transporter K02065 - - 0.000000000000000000000175 100.0
SHD2_k127_2210300_6 AI-2E family transporter - - - 0.0000000000002422 74.0
SHD2_k127_2210300_7 arginine decarboxylase activity K02626 - 4.1.1.19 0.00000001305 59.0
SHD2_k127_2249322_0 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 337.0
SHD2_k127_2249322_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 293.0
SHD2_k127_2249322_2 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005897 281.0
SHD2_k127_2249322_3 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
SHD2_k127_2249322_4 histidine kinase HAMP region domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000005286 236.0
SHD2_k127_2249322_5 Predicted membrane protein (DUF2318) - - - 0.000000000000000000000000921 111.0
SHD2_k127_2251424_0 PFAM Mannosyl oligosaccharide glucosidase - - - 0.0 1139.0
SHD2_k127_2251424_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000003241 231.0
SHD2_k127_2251424_2 curli production assembly transport component CsgG - - - 0.00000000000008193 71.0
SHD2_k127_2261297_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.59e-257 811.0
SHD2_k127_2261297_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.536e-228 721.0
SHD2_k127_2261297_10 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 432.0
SHD2_k127_2261297_11 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 406.0
SHD2_k127_2261297_12 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 381.0
SHD2_k127_2261297_13 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 355.0
SHD2_k127_2261297_14 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 351.0
SHD2_k127_2261297_15 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 351.0
SHD2_k127_2261297_16 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 317.0
SHD2_k127_2261297_17 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000154 253.0
SHD2_k127_2261297_18 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000003628 231.0
SHD2_k127_2261297_19 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000886 227.0
SHD2_k127_2261297_2 AMP-binding enzyme C-terminal domain K05939 - 2.3.1.40,6.2.1.20 5.101e-209 661.0
SHD2_k127_2261297_20 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000001556 226.0
SHD2_k127_2261297_21 helix_turn_helix, cAMP Regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000126 205.0
SHD2_k127_2261297_22 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000008472 192.0
SHD2_k127_2261297_23 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.0000000000000000000000000000000000000000001208 162.0
SHD2_k127_2261297_24 Glu-tRNAGln amidotransferase C subunit K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000002258 110.0
SHD2_k127_2261297_25 nucleotidyltransferase activity K07075 - - 0.000000000000000000000001022 111.0
SHD2_k127_2261297_26 - - - - 0.0000000000000000000006546 100.0
SHD2_k127_2261297_27 Domain of unknown function (DUF1858) - - - 0.0000000000000000002748 89.0
SHD2_k127_2261297_28 Uncharacterized ACR, COG1678 - - - 0.000000000000001142 80.0
SHD2_k127_2261297_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 2.243e-201 644.0
SHD2_k127_2261297_30 Aldehyde dehydrogenase family K00141,K22187 - 1.2.1.28 0.00000001305 58.0
SHD2_k127_2261297_32 4Fe-4S binding domain - - - 0.00002308 50.0
SHD2_k127_2261297_4 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 582.0
SHD2_k127_2261297_5 Peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 537.0
SHD2_k127_2261297_6 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 509.0
SHD2_k127_2261297_7 Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 503.0
SHD2_k127_2261297_8 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 448.0
SHD2_k127_2261297_9 phosphosulfolactate synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 422.0
SHD2_k127_2277864_0 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 523.0
SHD2_k127_2277864_1 long-chain fatty acid transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 402.0
SHD2_k127_2277864_2 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 348.0
SHD2_k127_2277864_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002001 279.0
SHD2_k127_2277864_4 Evidence 5 No homology to any previously reported sequences K07156,K07245,K14166 - - 0.0000000000000000000000000000000000000000000348 174.0
SHD2_k127_2277864_5 response to copper ion K07156,K14166 - - 0.000000000000000000000000000000007845 131.0
SHD2_k127_2277864_6 NosL - - - 0.0000000000000000000000000000003813 140.0
SHD2_k127_2277864_7 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000001283 87.0
SHD2_k127_2286419_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - 0.0 1950.0
SHD2_k127_2286419_1 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 303.0
SHD2_k127_2299354_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 477.0
SHD2_k127_2299354_1 Phosphoglucose isomerase K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000003556 197.0
SHD2_k127_2299354_2 Phosphoglucose isomerase K01810 - 5.3.1.9 0.000000003015 58.0
SHD2_k127_2299354_3 serine threonine protein kinase K12132 - 2.7.11.1 0.000000004284 68.0
SHD2_k127_2315388_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 1.956e-278 887.0
SHD2_k127_2315388_1 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000001737 158.0
SHD2_k127_2315388_2 SurA N-terminal domain K03769 - 5.2.1.8 0.00000583 57.0
SHD2_k127_2316582_0 Phosphoglycerate kinase K00927 - 2.7.2.3 9.996e-200 628.0
SHD2_k127_2316582_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 481.0
SHD2_k127_2316582_2 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 293.0
SHD2_k127_2316582_3 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000000000000000000000000002541 153.0
SHD2_k127_2323695_0 metal-dependent phosphohydrolase HD - - - 8.544e-208 665.0
SHD2_k127_2323695_1 type IV pilus assembly PilZ - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 507.0
SHD2_k127_2323695_2 Membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 398.0
SHD2_k127_2323695_3 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003006 285.0
SHD2_k127_2324019_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 4.956e-301 930.0
SHD2_k127_2324019_1 - - - - 0.000000000000000000000000000000000001122 146.0
SHD2_k127_2324019_2 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.00000000003867 63.0
SHD2_k127_2325584_0 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 348.0
SHD2_k127_2325584_1 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007875 331.0
SHD2_k127_2325584_2 glycosyl transferase group 1 - - - 0.000000000000000000000000000000004051 138.0
SHD2_k127_2327919_0 nucleotide-excision repair K03701 - - 1.84e-261 833.0
SHD2_k127_2327919_1 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 1.82e-217 687.0
SHD2_k127_2327919_2 PFAM NAD-dependent epimerase dehydratase K08678 - 4.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 526.0
SHD2_k127_2327919_3 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 459.0
SHD2_k127_2327919_4 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 416.0
SHD2_k127_2327919_5 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 388.0
SHD2_k127_2346770_0 Molecular chaperone. Has ATPase activity K04079 - - 8.004e-269 841.0
SHD2_k127_2346770_1 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 437.0
SHD2_k127_2346770_2 nucleoside-triphosphate diphosphatase activity K06287 - - 0.0000000000000000000000000000000000000000000000000004086 191.0
SHD2_k127_2346770_3 SMART Cold shock protein K03704 - - 0.000000000000000000000000007154 110.0
SHD2_k127_2351931_0 Sigma54 specific transcriptional regulator, Fis family - - - 1.835e-210 669.0
SHD2_k127_2351931_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 341.0
SHD2_k127_2351931_2 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000000000000000007211 184.0
SHD2_k127_2351931_3 competence protein - - - 0.00000009468 64.0
SHD2_k127_2351931_5 type IV pilus secretin PilQ K02666 - - 0.0003204 50.0
SHD2_k127_2358591_0 isocitrate dehydrogenase activity K00031 GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 570.0
SHD2_k127_2358591_1 PFAM AICARFT IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 385.0
SHD2_k127_2358591_2 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001734 278.0
SHD2_k127_2368064_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 1.355e-264 825.0
SHD2_k127_2368064_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.326e-203 642.0
SHD2_k127_2368064_10 Protein of unknown function (DUF2950) - - - 0.000001602 51.0
SHD2_k127_2368064_11 Evidence 5 No homology to any previously reported sequences - - - 0.00004313 48.0
SHD2_k127_2368064_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 486.0
SHD2_k127_2368064_3 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 382.0
SHD2_k127_2368064_4 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 356.0
SHD2_k127_2368064_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 327.0
SHD2_k127_2368064_6 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001941 267.0
SHD2_k127_2368064_7 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000000000000006587 184.0
SHD2_k127_2368064_8 Domain of unknown function (DUF4115) - - - 0.00000000000000005354 89.0
SHD2_k127_2368064_9 phosphorelay sensor kinase activity - - - 0.00000004085 55.0
SHD2_k127_2369714_0 Conserved region in glutamate synthase - - - 1.013e-272 846.0
SHD2_k127_2369714_1 PFAM ferredoxin-dependent glutamate synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 534.0
SHD2_k127_2369714_2 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 388.0
SHD2_k127_2369714_3 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.00000000000000000000000000000000000005834 143.0
SHD2_k127_2377711_0 PFAM S-adenosylmethionine synthetase (MAT) K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 575.0
SHD2_k127_2377711_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 546.0
SHD2_k127_2377711_10 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000001836 194.0
SHD2_k127_2377711_11 Thiamine-binding protein - - - 0.0000000000000000000000000000000006061 133.0
SHD2_k127_2377711_12 two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.000000000000000000000000000001829 127.0
SHD2_k127_2377711_13 JAB/MPN domain K21140 - 3.13.1.6 0.0000000000000000000000003388 109.0
SHD2_k127_2377711_14 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000002559 87.0
SHD2_k127_2377711_15 Tetratricopeptide repeat K07452 - - 0.000000004842 66.0
SHD2_k127_2377711_2 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 389.0
SHD2_k127_2377711_3 ThiF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 375.0
SHD2_k127_2377711_4 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004304 294.0
SHD2_k127_2377711_5 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002482 262.0
SHD2_k127_2377711_6 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000008235 239.0
SHD2_k127_2377711_7 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) K00564,K15460 - 2.1.1.172,2.1.1.223 0.000000000000000000000000000000000000000000000000000000000000000002535 233.0
SHD2_k127_2377711_8 Putative ATP-binding cassette K01992 - - 0.0000000000000000000000000000000000000000000000000000000001606 223.0
SHD2_k127_2377711_9 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000009329 198.0
SHD2_k127_2398767_0 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 1.12e-202 640.0
SHD2_k127_2398767_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 596.0
SHD2_k127_2398767_10 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 288.0
SHD2_k127_2398767_11 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000006311 215.0
SHD2_k127_2398767_12 Nucleotidyl transferase K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000001973 168.0
SHD2_k127_2398767_13 methyltransferase K16215 - 2.1.1.243 0.0000000000000000000000000000000000000001853 158.0
SHD2_k127_2398767_14 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000001073 156.0
SHD2_k127_2398767_15 Amino acid permease - - - 0.00000000000000000009013 91.0
SHD2_k127_2398767_2 PFAM outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 473.0
SHD2_k127_2398767_3 Glycosyl transferase family 2 K00721,K20534 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 439.0
SHD2_k127_2398767_4 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 438.0
SHD2_k127_2398767_5 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 406.0
SHD2_k127_2398767_6 Elongator protein 3, MiaB family, Radical SAM K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003574 379.0
SHD2_k127_2398767_7 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 370.0
SHD2_k127_2398767_8 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 325.0
SHD2_k127_2398767_9 GDP-mannose 4,6 dehydratase K19180 - 1.1.1.339 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 307.0
SHD2_k127_2406717_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 3.494e-243 764.0
SHD2_k127_2406717_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 441.0
SHD2_k127_2406717_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009837 325.0
SHD2_k127_2406717_3 isopentenyl-diphosphate delta-isomerase activity K00949,K01823 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.6.2,5.3.3.2 0.000000000000000000000000000000000000000000000002955 180.0
SHD2_k127_2406717_4 - - - - 0.00000000000000000002267 94.0
SHD2_k127_2476930_0 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 316.0
SHD2_k127_2476930_1 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000001323 168.0
SHD2_k127_2476930_2 PFAM V-type ATPase 116 kDa K02123 - - 0.0000000000000000000000222 105.0
SHD2_k127_247709_0 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006822 509.0
SHD2_k127_247709_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 359.0
SHD2_k127_247709_2 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000001403 215.0
SHD2_k127_247709_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00004506 51.0
SHD2_k127_2485874_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1790.0
SHD2_k127_2485874_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 6.098e-311 975.0
SHD2_k127_2485874_10 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 483.0
SHD2_k127_2485874_11 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 438.0
SHD2_k127_2485874_12 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001773 248.0
SHD2_k127_2485874_13 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000000000000000000001002 198.0
SHD2_k127_2485874_14 Protein of unknown function (DUF1810) - - - 0.000000000000000000000000000000000000000000000000000003701 193.0
SHD2_k127_2485874_15 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000002199 195.0
SHD2_k127_2485874_16 CHRD domain - - - 0.000000000000000000000000000000000000002564 152.0
SHD2_k127_2485874_17 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.000000000000000000000000000000000002141 149.0
SHD2_k127_2485874_18 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.0000000000000000000000000000001431 130.0
SHD2_k127_2485874_19 Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.000000000000000000000000000006323 126.0
SHD2_k127_2485874_2 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 1.603e-217 685.0
SHD2_k127_2485874_20 PFAM Smr protein MutS2 - - - 0.000000000000000000000000001257 121.0
SHD2_k127_2485874_21 PQ loop repeat K15383 - - 0.000000000000000000001072 98.0
SHD2_k127_2485874_22 response to copper ion - - - 0.000000000000000000005216 104.0
SHD2_k127_2485874_23 protein-glutamate methylesterase activity K00575,K03412,K03413,K07719 - 2.1.1.80,3.1.1.61,3.5.1.44 0.000000000000000008986 91.0
SHD2_k127_2485874_24 - - - - 0.0000000000000001945 82.0
SHD2_k127_2485874_25 Modulates RecA activity K03565,K19002 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 0.0000000000000004177 84.0
SHD2_k127_2485874_26 TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein K02044 - - 0.0004057 51.0
SHD2_k127_2485874_27 Glucose / Sorbosone dehydrogenase - - - 0.0006629 48.0
SHD2_k127_2485874_3 Domain of unknown function (DUF4139) - - - 7.41e-198 630.0
SHD2_k127_2485874_4 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 3.469e-195 621.0
SHD2_k127_2485874_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 576.0
SHD2_k127_2485874_6 ABC1 family K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 580.0
SHD2_k127_2485874_7 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 569.0
SHD2_k127_2485874_8 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 499.0
SHD2_k127_2485874_9 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 497.0
SHD2_k127_25736_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 7.811e-291 903.0
SHD2_k127_25736_1 Putative RNA methylase family UPF0020 K07444,K12297 - 2.1.1.173,2.1.1.264 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008419 460.0
SHD2_k127_25736_10 PFAM Pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000002306 164.0
SHD2_k127_25736_11 Hydrogenase (NiFe) small subunit HydA K05927,K06282,K18008 - 1.12.2.1,1.12.5.1,1.12.99.6 0.000000000000000000000000000000000000005102 148.0
SHD2_k127_25736_12 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000001268 134.0
SHD2_k127_25736_13 Protein of unknown function (DUF1189) - - - 0.000000000000000000000773 105.0
SHD2_k127_25736_14 PFAM cytochrome c class I - - - 0.0000000003455 64.0
SHD2_k127_25736_15 Response regulator receiver domain K03413 - - 0.000000008957 65.0
SHD2_k127_25736_2 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 377.0
SHD2_k127_25736_3 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 303.0
SHD2_k127_25736_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 306.0
SHD2_k127_25736_5 Histidine kinase K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009967 284.0
SHD2_k127_25736_6 Oligopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008178 271.0
SHD2_k127_25736_7 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000226 247.0
SHD2_k127_25736_8 Belongs to the acetyltransferase family. ArgA subfamily K00619,K14681 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000004858 233.0
SHD2_k127_25736_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000003471 233.0
SHD2_k127_258327_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 426.0
SHD2_k127_258327_1 pfam abc K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 353.0
SHD2_k127_258327_2 ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 310.0
SHD2_k127_258327_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001205 267.0
SHD2_k127_258327_4 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000742 269.0
SHD2_k127_258327_5 succinate dehydrogenase K00241,K00247 - - 0.0000000174 56.0
SHD2_k127_2584362_0 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 289.0
SHD2_k127_2584362_1 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000002896 265.0
SHD2_k127_2584362_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000003803 178.0
SHD2_k127_2584362_3 Protein of unknown function (DUF3309) - - - 0.0000000000000000002654 89.0
SHD2_k127_2584362_4 Belongs to the UPF0337 (CsbD) family - - - 0.00000000000007929 75.0
SHD2_k127_2655584_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.219e-207 657.0
SHD2_k127_2655584_1 endonuclease III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004444 256.0
SHD2_k127_2655584_2 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000000000001451 172.0
SHD2_k127_2655584_3 translation release factor activity - - - 0.000000000000000000000000000000000000000611 152.0
SHD2_k127_2655584_4 1,4-alpha-glucan branching enzyme activity - - - 0.000000000000000000000000000001295 127.0
SHD2_k127_2655584_5 SMART Cold shock protein K03704 - - 0.000000000000000000000001952 103.0
SHD2_k127_2715575_0 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 302.0
SHD2_k127_2715575_1 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000881 254.0
SHD2_k127_2715575_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000008644 199.0
SHD2_k127_2715575_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000001432 172.0
SHD2_k127_2715575_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000001539 172.0
SHD2_k127_2715575_5 Domain of unknown function (DUF3786) - - - 0.00000000000000000000000000000000000000000004532 167.0
SHD2_k127_2715575_6 Universal stress protein family K07090 - - 0.0000000000000000000000000000000003327 140.0
SHD2_k127_2715575_7 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.00000000000000000000000000000004382 130.0
SHD2_k127_2737000_0 Peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 340.0
SHD2_k127_2737000_1 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000101 231.0
SHD2_k127_2737000_2 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000005372 166.0
SHD2_k127_2737000_3 B12 binding domain K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000009629 172.0
SHD2_k127_2737000_4 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000000000247 132.0
SHD2_k127_2737000_5 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000005533 69.0
SHD2_k127_2737000_6 - K06039,K07092 - - 0.000002079 55.0
SHD2_k127_2819973_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 518.0
SHD2_k127_2819973_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 451.0
SHD2_k127_2819973_10 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.00006526 55.0
SHD2_k127_2819973_11 peptidyl-prolyl isomerase K07533 - 5.2.1.8 0.0007971 52.0
SHD2_k127_2819973_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 380.0
SHD2_k127_2819973_3 PFAM cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 305.0
SHD2_k127_2819973_4 NlpC/P60 family K20742 - 3.4.14.13 0.000000000000000000000000000000000002053 151.0
SHD2_k127_2819973_5 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000000007236 132.0
SHD2_k127_2819973_6 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000002128 119.0
SHD2_k127_2819973_7 - - - - 0.000000000004254 67.0
SHD2_k127_2819973_8 PFAM amino acid-binding ACT domain protein - - - 0.0000000001452 67.0
SHD2_k127_2819973_9 Domain of unknown function (DUF4912) K09942 - - 0.0000001588 63.0
SHD2_k127_2825564_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 2.199e-271 861.0
SHD2_k127_2825564_1 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009366 283.0
SHD2_k127_2825564_2 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000000000000000000007244 223.0
SHD2_k127_2825564_3 Domain of unknown function (DUF3842) - - - 0.0000000000000000000000000000000000000000000000008203 178.0
SHD2_k127_2825564_4 PFAM Cytochrome b5 - - - 0.00000000006736 65.0
SHD2_k127_2825564_5 helix_turn_helix, Lux Regulon - - - 0.0000001865 59.0
SHD2_k127_285009_0 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 549.0
SHD2_k127_285009_1 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 355.0
SHD2_k127_285009_2 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003707 274.0
SHD2_k127_285009_3 GYD domain - - - 0.000000000000000000000000000000000009372 138.0
SHD2_k127_285009_4 sulfur carrier activity K04085 - - 0.00000000000000000000000117 104.0
SHD2_k127_285009_5 - - - - 0.00000001411 56.0
SHD2_k127_2870638_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 505.0
SHD2_k127_2870638_1 DHHA2 domain K15986 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 502.0
SHD2_k127_2870638_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 492.0
SHD2_k127_2870638_3 - - - - 0.0000000000000000000000003277 105.0
SHD2_k127_2870638_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000003027 103.0
SHD2_k127_2870638_5 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000007365 81.0
SHD2_k127_2870638_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.0000000000006889 74.0
SHD2_k127_3181628_0 ATPase BadF BadG BcrA BcrD type - - - 0.0 1547.0
SHD2_k127_3181628_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.858e-266 837.0
SHD2_k127_3181628_10 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000003555 193.0
SHD2_k127_3181628_11 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000000000000005136 160.0
SHD2_k127_3181628_12 SMART HNH nuclease K07451 - - 0.0000000000000000000000000000000000000005671 153.0
SHD2_k127_3181628_13 Pyridoxamine 5'-phosphate oxidase like - - - 0.000000000000000000000000000000000004855 141.0
SHD2_k127_3181628_14 Protein of unknown function (DUF507) - - - 0.0000000000000000000000000001202 117.0
SHD2_k127_3181628_15 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000115 115.0
SHD2_k127_3181628_16 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000001714 104.0
SHD2_k127_3181628_17 Protein of unknown function (DUF507) - - - 0.000000000000000000000003263 104.0
SHD2_k127_3181628_18 4Fe-4S binding domain - - - 0.000000000000000009756 84.0
SHD2_k127_3181628_19 Prokaryotic N-terminal methylation motif K02456,K02650 - - 0.000000009282 65.0
SHD2_k127_3181628_2 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 492.0
SHD2_k127_3181628_3 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 469.0
SHD2_k127_3181628_4 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 355.0
SHD2_k127_3181628_5 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 306.0
SHD2_k127_3181628_6 PFAM Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 289.0
SHD2_k127_3181628_7 PSP1 C-terminal conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001333 254.0
SHD2_k127_3181628_8 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000001009 219.0
SHD2_k127_3181628_9 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000007086 225.0
SHD2_k127_3188035_0 Tfp pilus assembly protein tip-associated adhesin K02674 - - 4.898e-204 703.0
SHD2_k127_3188035_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 557.0
SHD2_k127_3198311_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1089.0
SHD2_k127_3198311_1 Domain in cystathionine beta-synthase and other proteins. K07182 - - 5.759e-256 804.0
SHD2_k127_3198311_2 Sodium:solute symporter family K14393 - - 3.844e-196 627.0
SHD2_k127_3198311_3 His Kinase A (phospho-acceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007342 572.0
SHD2_k127_3198311_4 Sigma-54 interaction domain K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 471.0
SHD2_k127_3198311_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000002372 149.0
SHD2_k127_3198311_6 Protein of unknown function, DUF485 - - - 0.0000000000000000000000000003881 117.0
SHD2_k127_3198311_7 Protein of unknown function, DUF488 - - - 0.0000000000000001012 80.0
SHD2_k127_320281_0 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007808 528.0
SHD2_k127_320281_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000001322 208.0
SHD2_k127_320281_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000008353 198.0
SHD2_k127_320281_3 cheY-homologous receiver domain - - - 0.0000000000000000000000000000005391 126.0
SHD2_k127_320281_4 Conserved hypothetical protein 698 - - - 0.0000000007035 69.0
SHD2_k127_3228418_0 Domain of unknown function (DUF3458_C) ARM repeats K01256,K08776 - 3.4.11.2 0.0 1229.0
SHD2_k127_3228418_1 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002211 265.0
SHD2_k127_3232694_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 4.223e-278 869.0
SHD2_k127_3232694_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 3.254e-236 739.0
SHD2_k127_3232694_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 412.0
SHD2_k127_3232694_11 Type II secretion system (T2SS), protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 395.0
SHD2_k127_3232694_12 SMART AAA ATPase K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 391.0
SHD2_k127_3232694_13 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 346.0
SHD2_k127_3232694_14 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 339.0
SHD2_k127_3232694_15 Glycosyl transferase, family 2 K12992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 321.0
SHD2_k127_3232694_16 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 330.0
SHD2_k127_3232694_17 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 302.0
SHD2_k127_3232694_18 export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007596 284.0
SHD2_k127_3232694_19 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001642 278.0
SHD2_k127_3232694_2 DEAD DEAH box helicase K06877 - - 8.133e-213 685.0
SHD2_k127_3232694_20 Putative beta-barrel porin 2 K20920 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001476 285.0
SHD2_k127_3232694_21 glycolate biosynthetic process K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000004562 243.0
SHD2_k127_3232694_22 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005001 244.0
SHD2_k127_3232694_23 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000005662 243.0
SHD2_k127_3232694_24 PFAM NADH Ubiquinone - - - 0.00000000000000000000000000000000000000000000000000000000000000008964 227.0
SHD2_k127_3232694_25 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000000000006478 220.0
SHD2_k127_3232694_26 - - - - 0.000000000000000000000000000000000000000000000000000000001339 206.0
SHD2_k127_3232694_27 Peptidylprolyl isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000009107 203.0
SHD2_k127_3232694_28 Bacterial regulatory proteins, crp family - - - 0.00000000000000000000000000000000000000000000000001791 188.0
SHD2_k127_3232694_29 Cytidine and deoxycytidylate deaminase zinc-binding region K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000002536 179.0
SHD2_k127_3232694_3 Chain length determinant protein K16554 - - 6.921e-208 670.0
SHD2_k127_3232694_30 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000001391 173.0
SHD2_k127_3232694_31 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000008846 167.0
SHD2_k127_3232694_32 phosphatase activity K05967 - - 0.000000000000000000000000000000000000000006324 160.0
SHD2_k127_3232694_34 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000004262 149.0
SHD2_k127_3232694_35 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000001389 153.0
SHD2_k127_3232694_36 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.000000000000000000000000000000000001314 144.0
SHD2_k127_3232694_37 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000001337 148.0
SHD2_k127_3232694_38 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000003321 142.0
SHD2_k127_3232694_39 protein-disulfide reductase activity - - - 0.000000000000000000000000002159 116.0
SHD2_k127_3232694_4 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 1.813e-196 633.0
SHD2_k127_3232694_40 Glycosyltransferase like family 2 K20444 - - 0.00000000000000000000001373 113.0
SHD2_k127_3232694_42 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000004254 110.0
SHD2_k127_3232694_43 Type II secretion system protein B K02451 - - 0.000000000000001118 85.0
SHD2_k127_3232694_44 FHA domain - - - 0.00000000001382 75.0
SHD2_k127_3232694_45 Fimbrial assembly protein (PilN) - - - 0.0000000001753 74.0
SHD2_k127_3232694_46 - - - - 0.000000005053 57.0
SHD2_k127_3232694_47 General secretion pathway protein K02457 - - 0.000000008829 64.0
SHD2_k127_3232694_48 fimbrial assembly K02461 - - 0.00000002016 67.0
SHD2_k127_3232694_49 Belongs to the peptidase S26 family K13280 - 3.4.21.89 0.00000003294 65.0
SHD2_k127_3232694_5 NADH Ubiquinone plastoquinone (Complex I) K12141 - - 6.716e-195 618.0
SHD2_k127_3232694_50 - - - - 0.0000002514 55.0
SHD2_k127_3232694_51 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000007675 54.0
SHD2_k127_3232694_52 Prokaryotic N-terminal methylation motif K02458 - - 0.000003021 54.0
SHD2_k127_3232694_53 Type II secretion system (T2SS), protein M subtype b - - - 0.000006199 56.0
SHD2_k127_3232694_54 Protein of unknown function (DUF2934) - - - 0.00005518 49.0
SHD2_k127_3232694_55 Prokaryotic N-terminal methylation motif K02456,K02457,K02458,K02459,K02655,K10926 - - 0.0001581 52.0
SHD2_k127_3232694_56 - - - - 0.0005457 50.0
SHD2_k127_3232694_6 type II secretion system protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 565.0
SHD2_k127_3232694_7 Lipid A core-O-antigen ligase-like enyme K18814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 562.0
SHD2_k127_3232694_8 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 531.0
SHD2_k127_3232694_9 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000854 476.0
SHD2_k127_3235350_0 General secretory system II, protein E domain protein K02652 - - 2.353e-217 691.0
SHD2_k127_3235350_1 FAD binding domain K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 625.0
SHD2_k127_3235350_2 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 546.0
SHD2_k127_3235350_3 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 475.0
SHD2_k127_3235350_4 Type II secretion system (T2SS), protein F K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 378.0
SHD2_k127_3235350_5 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 335.0
SHD2_k127_3235350_6 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000002268 195.0
SHD2_k127_3235350_7 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.0000000000000000000000000000000000000005048 153.0
SHD2_k127_3235350_8 Uncharacterised protein family UPF0102 K07460 - - 0.0000000000000000000000000008242 116.0
SHD2_k127_3235350_9 Belongs to the LOG family K06966 - 3.2.2.10 0.000000001222 59.0
SHD2_k127_3235730_0 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 505.0
SHD2_k127_3235730_1 TIGRFAM cytochrome C family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 398.0
SHD2_k127_3235730_2 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007274 285.0
SHD2_k127_3235730_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000503 278.0
SHD2_k127_3235730_4 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000004401 206.0
SHD2_k127_3235730_5 Response regulator receiver - - - 0.00002168 55.0
SHD2_k127_3242530_0 DEAD DEAH box helicase K03654 - 3.6.4.12 1.587e-217 685.0
SHD2_k127_3297894_0 PFAM magnesium chelatase ChlI subunit K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 606.0
SHD2_k127_3297894_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 314.0
SHD2_k127_3297894_3 Regulatory protein, FmdB family - - - 0.000000000000000002533 86.0
SHD2_k127_3297894_4 - - - - 0.0001952 50.0
SHD2_k127_3298982_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.457e-311 973.0
SHD2_k127_3298982_1 Carbohydrate phosphorylase K00688 - 2.4.1.1 1.466e-258 807.0
SHD2_k127_3298982_2 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 432.0
SHD2_k127_3298982_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 410.0
SHD2_k127_3298982_4 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004374 271.0
SHD2_k127_3298982_5 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000003698 229.0
SHD2_k127_3298982_6 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000008795 112.0
SHD2_k127_3298982_7 RDD family - - - 0.00000000000000000000000003211 112.0
SHD2_k127_3298982_8 exodeoxyribonuclease I activity - - - 0.00000000000005541 75.0
SHD2_k127_3325499_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 365.0
SHD2_k127_3325499_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000626 349.0
SHD2_k127_3325499_2 Archaeal transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000002376 166.0
SHD2_k127_3325499_3 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000006448 154.0
SHD2_k127_3325499_5 - - - - 0.0000005263 51.0
SHD2_k127_3333061_0 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 468.0
SHD2_k127_3333061_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 310.0
SHD2_k127_3333061_2 PFAM TonB-dependent Receptor Plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009266 273.0
SHD2_k127_3333061_3 PFAM Phosphoglycerate mutase K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000007011 245.0
SHD2_k127_3333061_4 Pfam SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000002914 216.0
SHD2_k127_3333061_5 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000004416 219.0
SHD2_k127_3333061_6 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000002823 194.0
SHD2_k127_3333061_7 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000003431 200.0
SHD2_k127_3333061_8 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000000000000000000000000000000000003468 192.0
SHD2_k127_3333061_9 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000001742 148.0
SHD2_k127_3343991_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 417.0
SHD2_k127_3343991_1 Catalyzes the conversion of dihydroorotate to orotate K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 380.0
SHD2_k127_3343991_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000002861 232.0
SHD2_k127_3343991_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000000009922 236.0
SHD2_k127_3343991_4 FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000000000000000000000000000000000000000000000006648 192.0
SHD2_k127_3343991_5 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000000000000000000000000000000004599 184.0
SHD2_k127_3343991_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000007789 153.0
SHD2_k127_3343991_7 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000004732 121.0
SHD2_k127_3343991_8 Sulfurtransferase TusA - - - 0.000000000000000000000003548 104.0
SHD2_k127_3348170_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 7.122e-278 878.0
SHD2_k127_3348170_1 Glycosyl hydrolase family 57 - - - 4.18e-238 757.0
SHD2_k127_3348170_10 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000006955 146.0
SHD2_k127_3348170_11 - - - - 0.000000000000000000000000000000003158 145.0
SHD2_k127_3348170_12 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.000000000000000000009463 92.0
SHD2_k127_3348170_13 cell cycle K05589,K12065,K13052 - - 0.00000000000001849 77.0
SHD2_k127_3348170_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 596.0
SHD2_k127_3348170_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 484.0
SHD2_k127_3348170_4 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 479.0
SHD2_k127_3348170_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 431.0
SHD2_k127_3348170_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005606 391.0
SHD2_k127_3348170_7 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 380.0
SHD2_k127_3348170_8 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008862 275.0
SHD2_k127_3348170_9 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000000000000006275 156.0
SHD2_k127_3359360_0 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0 1097.0
SHD2_k127_3359360_1 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.0 1080.0
SHD2_k127_3359360_10 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 349.0
SHD2_k127_3359360_11 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 335.0
SHD2_k127_3359360_12 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 313.0
SHD2_k127_3359360_13 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 296.0
SHD2_k127_3359360_14 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006738 269.0
SHD2_k127_3359360_15 histidine kinase, HAMP K07642 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000005637 248.0
SHD2_k127_3359360_16 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000002253 235.0
SHD2_k127_3359360_17 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000008656 187.0
SHD2_k127_3359360_18 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000009765 186.0
SHD2_k127_3359360_19 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000000000000000000007217 177.0
SHD2_k127_3359360_2 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 2.314e-254 796.0
SHD2_k127_3359360_20 cyclic nucleotide-binding - - - 0.000000000000000000000000000000000000000000002916 169.0
SHD2_k127_3359360_21 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 - 2.5.1.17 0.0000000000000000000000000000000000000003575 154.0
SHD2_k127_3359360_22 Domain of unknown function (DUF4416) - - - 0.000000000000000000000000000000000000004753 155.0
SHD2_k127_3359360_23 Thioredoxin-like - - - 0.00000000000000000000000000000000001142 141.0
SHD2_k127_3359360_24 Poly A polymerase head domain K00970,K00974,K07276,K19545 - 2.7.7.19,2.7.7.72 0.00000000000000000000002758 113.0
SHD2_k127_3359360_25 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000002026 73.0
SHD2_k127_3359360_26 - - - - 0.00000886 48.0
SHD2_k127_3359360_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 2.254e-230 724.0
SHD2_k127_3359360_4 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 512.0
SHD2_k127_3359360_5 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 509.0
SHD2_k127_3359360_6 Ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 416.0
SHD2_k127_3359360_7 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 394.0
SHD2_k127_3359360_8 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00437,K05922,K06281 - 1.12.2.1,1.12.5.1,1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008572 383.0
SHD2_k127_3359360_9 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 374.0
SHD2_k127_3369645_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 3.651e-203 638.0
SHD2_k127_3369645_1 Cytochrome C assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 366.0
SHD2_k127_3369645_2 PFAM ResB family protein K07399 - - 0.00000000000000000000000000000000000000000000000000000007481 203.0
SHD2_k127_3369645_3 NmrA-like family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000002787 203.0
SHD2_k127_3369645_4 acetyltransferase - - - 0.000000000000000000000313 99.0
SHD2_k127_3369645_5 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000006367 93.0
SHD2_k127_3389_0 Domain of unknown function (DUF296) - - - 0.000000000000000000000000000000000000000000000000000001311 194.0
SHD2_k127_3473338_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 574.0
SHD2_k127_3483718_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 4.884e-215 674.0
SHD2_k127_3483718_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 357.0
SHD2_k127_3483718_10 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000009454 205.0
SHD2_k127_3483718_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000005801 201.0
SHD2_k127_3483718_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000001996 175.0
SHD2_k127_3483718_13 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000543 176.0
SHD2_k127_3483718_14 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000003155 163.0
SHD2_k127_3483718_15 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000005833 145.0
SHD2_k127_3483718_16 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000002822 134.0
SHD2_k127_3483718_17 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.000000000000000000000000000000001229 130.0
SHD2_k127_3483718_18 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000001207 133.0
SHD2_k127_3483718_19 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000001897 111.0
SHD2_k127_3483718_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 332.0
SHD2_k127_3483718_20 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000001906 105.0
SHD2_k127_3483718_21 Ribosomal protein L36 K02919 - - 0.00000000000000124 76.0
SHD2_k127_3483718_22 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000001063 74.0
SHD2_k127_3483718_23 Ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000005825 64.0
SHD2_k127_3483718_3 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 327.0
SHD2_k127_3483718_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 281.0
SHD2_k127_3483718_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003713 281.0
SHD2_k127_3483718_6 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000008933 229.0
SHD2_k127_3483718_7 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000001658 231.0
SHD2_k127_3483718_8 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000684 214.0
SHD2_k127_3483718_9 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000001176 208.0
SHD2_k127_3493394_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 8.262e-226 717.0
SHD2_k127_3493394_1 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 418.0
SHD2_k127_3493394_10 PFAM Nitrate reductase gamma subunit - - - 0.0000000008807 69.0
SHD2_k127_3493394_2 Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate K15527 - 2.5.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 340.0
SHD2_k127_3493394_3 Methionine synthase, cobalamin (vitamin B12)-binding module, cap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 319.0
SHD2_k127_3493394_4 PFAM Cysteine-rich domain K08264 - 1.8.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 328.0
SHD2_k127_3493394_5 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 323.0
SHD2_k127_3493394_6 TIGRFAM iron-sulfur cluster binding protein - - - 0.00000000000000000000000000000000000000000000005168 176.0
SHD2_k127_3493394_7 PFAM Nitrate reductase gamma subunit - - - 0.00000000000000000000000007061 115.0
SHD2_k127_3493394_8 - - - - 0.00000000000001215 78.0
SHD2_k127_3493394_9 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.0000000000004266 70.0
SHD2_k127_3545744_0 Cation transporter/ATPase, N-terminus K01531,K12955 - 3.6.3.2 0.0 1206.0
SHD2_k127_3545744_1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 481.0
SHD2_k127_3545744_2 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002072 253.0
SHD2_k127_3545744_3 S4 domain K14761 - - 0.000000000000000000003135 95.0
SHD2_k127_3545744_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000001104 91.0
SHD2_k127_3557491_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 612.0
SHD2_k127_3557491_1 PFAM phosphofructokinase K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 544.0
SHD2_k127_3557491_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000000000000000000000000000000000000000000002627 222.0
SHD2_k127_3557491_3 MGS-like domain - - - 0.0000000000000000000000000000000000000000003112 164.0
SHD2_k127_3557491_4 Belongs to the CarB family K01955 - 6.3.5.5 0.00000000001838 64.0
SHD2_k127_3565646_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.082e-254 789.0
SHD2_k127_3565646_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.133e-242 757.0
SHD2_k127_3565646_10 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 327.0
SHD2_k127_3565646_11 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000114 209.0
SHD2_k127_3565646_12 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000438 204.0
SHD2_k127_3565646_13 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000001625 159.0
SHD2_k127_3565646_14 ATP synthesis coupled proton transport K02109,K18682 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000004427 155.0
SHD2_k127_3565646_15 PFAM Amidohydrolase 2 - - - 0.00000000000000000000000000000000002937 148.0
SHD2_k127_3565646_16 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.000000000000000000000000000000007261 131.0
SHD2_k127_3565646_17 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000008493 133.0
SHD2_k127_3565646_18 Protein required for attachment to host cells - - - 0.000000000000000000000000006335 117.0
SHD2_k127_3565646_19 ATP synthesis coupled proton transport K02109 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - 0.0000000000000000000000001686 110.0
SHD2_k127_3565646_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 6.699e-237 756.0
SHD2_k127_3565646_21 Autoinducer binding domain K20334 - - 0.000000000000000615 80.0
SHD2_k127_3565646_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.362e-222 706.0
SHD2_k127_3565646_4 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 520.0
SHD2_k127_3565646_5 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 469.0
SHD2_k127_3565646_6 TonB dependent receptor K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 480.0
SHD2_k127_3565646_7 response regulator receiver K02481,K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 394.0
SHD2_k127_3565646_8 Domains HAMP, HisKA, HATPase_c, REC K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 391.0
SHD2_k127_3565646_9 radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 386.0
SHD2_k127_3582175_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 552.0
SHD2_k127_3582175_1 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 369.0
SHD2_k127_3582175_2 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 322.0
SHD2_k127_3582175_3 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008969 278.0
SHD2_k127_3582175_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007111 265.0
SHD2_k127_3594238_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 306.0
SHD2_k127_3594238_1 Domain of unknown function (DUF296) - - - 0.0000000000007216 68.0
SHD2_k127_3594238_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000006035 62.0
SHD2_k127_3598109_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 2.754e-241 760.0
SHD2_k127_3598109_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 5.343e-237 745.0
SHD2_k127_3598109_2 Aminotransferase class-III K01845 - 5.4.3.8 1.746e-202 638.0
SHD2_k127_3598109_3 Polysulphide reductase, NrfD - - - 1.973e-195 616.0
SHD2_k127_3598109_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006277 436.0
SHD2_k127_3598109_5 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000007308 233.0
SHD2_k127_3598109_6 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000001547 209.0
SHD2_k127_3598109_7 heat shock protein binding - - - 0.0000000000000000000000000000000000319 147.0
SHD2_k127_3598109_8 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds K01666 - 4.1.3.39 0.0000000004199 61.0
SHD2_k127_3624787_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044464,GO:0044769,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1902600 3.6.3.14,3.6.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 559.0
SHD2_k127_3624787_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 495.0
SHD2_k127_3624787_2 PFAM V-type ATPase 116 kDa K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 392.0
SHD2_k127_3624787_3 ATP synthase subunit D K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000007119 228.0
SHD2_k127_3624787_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000002562 124.0
SHD2_k127_3624787_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000000000005615 114.0
SHD2_k127_3624787_7 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.000000000000000000000002205 104.0
SHD2_k127_3624787_8 Protein of unknown function (DUF2892) - - - 0.000000134 56.0
SHD2_k127_39076_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 545.0
SHD2_k127_39076_1 oligosaccharyl transferase activity - - - 0.0000000036 62.0
SHD2_k127_39076_2 S-layer homology domain - - - 0.000003286 52.0
SHD2_k127_39076_3 SurA N-terminal domain K03771 - 5.2.1.8 0.00001293 55.0
SHD2_k127_39076_4 Glycosyl transferase family 2 - - - 0.0004736 42.0
SHD2_k127_4017532_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.696e-236 740.0
SHD2_k127_4017532_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005029 580.0
SHD2_k127_4017532_2 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 526.0
SHD2_k127_4017532_3 Metalloenzyme superfamily K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 524.0
SHD2_k127_4017532_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000002294 210.0
SHD2_k127_4017532_5 ThiS family K03636 - - 0.00000000000000000000000000000000113 132.0
SHD2_k127_4017532_6 NIL - - - 0.000000000000000000000000009561 113.0
SHD2_k127_4017532_7 PFAM response regulator receiver - - - 0.0000004302 60.0
SHD2_k127_40369_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 578.0
SHD2_k127_40369_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 573.0
SHD2_k127_40369_10 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 315.0
SHD2_k127_40369_11 metal-dependent enzyme K09153 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 298.0
SHD2_k127_40369_12 PFAM HPP family K07168 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005916 262.0
SHD2_k127_40369_13 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001704 265.0
SHD2_k127_40369_14 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000001577 235.0
SHD2_k127_40369_15 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000003496 201.0
SHD2_k127_40369_16 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000003688 201.0
SHD2_k127_40369_17 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000002168 197.0
SHD2_k127_40369_18 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000001436 185.0
SHD2_k127_40369_19 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000002835 183.0
SHD2_k127_40369_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 580.0
SHD2_k127_40369_20 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000008014 151.0
SHD2_k127_40369_21 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000000000000001715 151.0
SHD2_k127_40369_22 phosphorelay signal transduction system - - - 0.0000000000000000000000000000267 121.0
SHD2_k127_40369_23 Binds the 23S rRNA K02909 - - 0.00000000000000000000000002805 109.0
SHD2_k127_40369_24 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000001867 94.0
SHD2_k127_40369_26 PFAM Uncharacterised protein family UPF0150 - - - 0.0002689 46.0
SHD2_k127_40369_3 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 559.0
SHD2_k127_40369_4 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 560.0
SHD2_k127_40369_5 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 509.0
SHD2_k127_40369_6 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 495.0
SHD2_k127_40369_7 Chemotaxis sensory transducer K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 425.0
SHD2_k127_40369_8 response regulator K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 379.0
SHD2_k127_40369_9 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 342.0
SHD2_k127_4232415_0 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 492.0
SHD2_k127_4232415_2 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000002497 230.0
SHD2_k127_4274083_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.437e-276 863.0
SHD2_k127_4274083_1 membrane transporter protein K07090 - - 3.503e-204 642.0
SHD2_k127_4274083_2 isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 459.0
SHD2_k127_4274083_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001306 263.0
SHD2_k127_4274083_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000005471 191.0
SHD2_k127_4274083_5 PFAM UspA - - - 0.00000000000000000000000000000000000000000000000001384 190.0
SHD2_k127_4274083_6 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000004061 129.0
SHD2_k127_4297756_0 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 586.0
SHD2_k127_4297756_1 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 515.0
SHD2_k127_4297756_10 - - - - 0.000000000000000000000000000000000000000000000000005013 184.0
SHD2_k127_4297756_11 Protein of unknown function (DUF1255) K09913 - 2.4.2.1,2.4.2.2 0.0000000000000000000000000000000000000000000000147 172.0
SHD2_k127_4297756_12 UTRA K03710 - - 0.0000000000000000000000000000002419 132.0
SHD2_k127_4297756_13 Universal stress protein family K07090 - - 0.00000000000000000000000000001122 124.0
SHD2_k127_4297756_14 Cold shock K03704 - - 0.000000000000000000000000002764 111.0
SHD2_k127_4297756_16 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000000000004374 102.0
SHD2_k127_4297756_17 - - - - 0.000000000000000001242 88.0
SHD2_k127_4297756_18 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity K03182 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 0.0000000000000001272 79.0
SHD2_k127_4297756_19 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000409 65.0
SHD2_k127_4297756_2 protein secretion K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 533.0
SHD2_k127_4297756_3 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 490.0
SHD2_k127_4297756_4 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 461.0
SHD2_k127_4297756_5 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 476.0
SHD2_k127_4297756_6 TIGRFAM cysteine K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000552 423.0
SHD2_k127_4297756_7 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 409.0
SHD2_k127_4297756_8 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000000000007975 220.0
SHD2_k127_4297756_9 histidine kinase HAMP region domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000001722 220.0
SHD2_k127_4311862_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006 - 2.7.9.1 0.0 1193.0
SHD2_k127_4311862_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1131.0
SHD2_k127_4311862_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 589.0
SHD2_k127_4311862_11 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 587.0
SHD2_k127_4311862_12 family UPF0324 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 583.0
SHD2_k127_4311862_13 GAF domain K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 548.0
SHD2_k127_4311862_14 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 502.0
SHD2_k127_4311862_15 7TM receptor with intracellular HD hydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008629 498.0
SHD2_k127_4311862_16 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 454.0
SHD2_k127_4311862_17 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 441.0
SHD2_k127_4311862_18 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 391.0
SHD2_k127_4311862_19 Family 5 K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 366.0
SHD2_k127_4311862_2 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 1.5e-323 1000.0
SHD2_k127_4311862_20 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 344.0
SHD2_k127_4311862_21 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007997 347.0
SHD2_k127_4311862_22 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528,K16951 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000947 338.0
SHD2_k127_4311862_23 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 336.0
SHD2_k127_4311862_24 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 326.0
SHD2_k127_4311862_25 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 333.0
SHD2_k127_4311862_26 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 314.0
SHD2_k127_4311862_27 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 311.0
SHD2_k127_4311862_28 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 309.0
SHD2_k127_4311862_29 helix_turn_helix, Lux Regulon K02282,K07689 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002696 296.0
SHD2_k127_4311862_3 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 2.028e-292 913.0
SHD2_k127_4311862_30 tRNA (Guanine-1)-methyltransferase K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 286.0
SHD2_k127_4311862_31 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003817 277.0
SHD2_k127_4311862_32 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004534 277.0
SHD2_k127_4311862_33 PFAM Integral membrane protein TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003263 272.0
SHD2_k127_4311862_34 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005389 272.0
SHD2_k127_4311862_35 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000001115 265.0
SHD2_k127_4311862_36 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000001762 263.0
SHD2_k127_4311862_37 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000181 254.0
SHD2_k127_4311862_38 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004244 271.0
SHD2_k127_4311862_39 Cytidylate kinase-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000146 253.0
SHD2_k127_4311862_4 PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 1.789e-268 845.0
SHD2_k127_4311862_40 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000003537 236.0
SHD2_k127_4311862_41 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000008455 236.0
SHD2_k127_4311862_42 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000003383 227.0
SHD2_k127_4311862_43 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000001069 229.0
SHD2_k127_4311862_44 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000004584 214.0
SHD2_k127_4311862_45 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000008089 215.0
SHD2_k127_4311862_47 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000003152 219.0
SHD2_k127_4311862_48 Diacylglycerol kinase K00887,K00901 - 2.7.1.107,2.7.1.66 0.0000000000000000000000000000000000000000000000000000001635 202.0
SHD2_k127_4311862_49 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000187 198.0
SHD2_k127_4311862_5 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 4.364e-232 725.0
SHD2_k127_4311862_50 CHASE K02488,K21009 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000002422 207.0
SHD2_k127_4311862_51 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000004367 191.0
SHD2_k127_4311862_52 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - 0.00000000000000000000000000000000000000000000000000002044 194.0
SHD2_k127_4311862_53 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000003248 207.0
SHD2_k127_4311862_54 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000001955 189.0
SHD2_k127_4311862_55 Thioredoxin-like domain K03671 - - 0.00000000000000000000000000000000000000000000000002816 180.0
SHD2_k127_4311862_56 PFAM iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000000000063 185.0
SHD2_k127_4311862_57 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000001459 178.0
SHD2_k127_4311862_58 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.0000000000000000000000000000000000000000001105 170.0
SHD2_k127_4311862_59 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000001071 178.0
SHD2_k127_4311862_6 NADH dehydrogenase - - - 4.188e-227 719.0
SHD2_k127_4311862_60 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000005146 167.0
SHD2_k127_4311862_61 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000004057 148.0
SHD2_k127_4311862_62 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000007108 150.0
SHD2_k127_4311862_63 PFAM CBS domain - - - 0.000000000000000000000000000000000006378 141.0
SHD2_k127_4311862_64 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000000000000001135 128.0
SHD2_k127_4311862_65 cell redox homeostasis K02199 - - 0.00000000000000000000000000000001292 134.0
SHD2_k127_4311862_67 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000003072 125.0
SHD2_k127_4311862_68 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000001072 134.0
SHD2_k127_4311862_69 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000005932 118.0
SHD2_k127_4311862_7 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00123,K00336,K05299,K06441 - 1.12.7.2,1.17.1.10,1.17.1.9,1.6.5.3 5.741e-225 715.0
SHD2_k127_4311862_70 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000002545 112.0
SHD2_k127_4311862_71 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000000000002715 111.0
SHD2_k127_4311862_72 Hydrolase, P-loop family K06925 - - 0.0000000000000000000000002948 110.0
SHD2_k127_4311862_73 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000008716 100.0
SHD2_k127_4311862_74 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000001009 98.0
SHD2_k127_4311862_75 Protein of unknown function (DUF2905) - - - 0.00000000000000000006758 93.0
SHD2_k127_4311862_76 PFAM Methylamine - - - 0.0000000000000001263 86.0
SHD2_k127_4311862_78 AI-2E family transporter - - - 0.000000000121 64.0
SHD2_k127_4311862_79 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000002008 61.0
SHD2_k127_4311862_8 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 607.0
SHD2_k127_4311862_80 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000007749 64.0
SHD2_k127_4311862_81 COG2200 FOG EAL domain K20963 - 3.1.4.52 0.000000002317 66.0
SHD2_k127_4311862_83 protein secretion K03116,K03117 - - 0.0000008588 53.0
SHD2_k127_4311862_84 peptidyl-tyrosine sulfation - - - 0.0004021 47.0
SHD2_k127_4311862_9 5-formyltetrahydrofolate cyclo-ligase activity K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 604.0
SHD2_k127_4359311_0 FtsX-like permease family K02004 - - 4.522e-320 996.0
SHD2_k127_4359311_1 TIGRFAM efflux transporter, RND family, MFP subunit K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 387.0
SHD2_k127_4359311_2 PFAM ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 355.0
SHD2_k127_4359311_3 Chemotaxis sensory transducer K03406 - - 0.00000000001197 68.0
SHD2_k127_4360549_0 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 1.989e-262 822.0
SHD2_k127_4360549_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000319 242.0
SHD2_k127_4360549_2 4Fe-4S dicluster domain K00196 - - 0.00000000000000000000000000000000000000000000000007124 182.0
SHD2_k127_4366275_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 3.724e-218 686.0
SHD2_k127_4366275_1 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 561.0
SHD2_k127_4366275_10 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 364.0
SHD2_k127_4366275_11 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 368.0
SHD2_k127_4366275_12 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 309.0
SHD2_k127_4366275_13 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 328.0
SHD2_k127_4366275_14 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 304.0
SHD2_k127_4366275_15 Pfam:Arch_ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 288.0
SHD2_k127_4366275_16 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 286.0
SHD2_k127_4366275_17 ATPases associated with a variety of cellular activities K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000234 286.0
SHD2_k127_4366275_18 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000195 273.0
SHD2_k127_4366275_19 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004255 273.0
SHD2_k127_4366275_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 548.0
SHD2_k127_4366275_20 HEAT repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003727 276.0
SHD2_k127_4366275_21 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005898 274.0
SHD2_k127_4366275_22 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000000000000000000001487 221.0
SHD2_k127_4366275_23 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000002125 204.0
SHD2_k127_4366275_24 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000000000000000000000000000000004032 186.0
SHD2_k127_4366275_25 Response regulator receiver domain K03413 - - 0.000000000000000000000000000000000000000000009215 165.0
SHD2_k127_4366275_26 PFAM response regulator receiver K03413 - - 0.000000000000000000000000000000000000003253 149.0
SHD2_k127_4366275_27 regulator, PATAN and FRGAF domain-containing - - - 0.000000000000000000000000000000000000006759 159.0
SHD2_k127_4366275_28 OstA-like protein K09774 - - 0.0000000000000000000000000000000000001908 145.0
SHD2_k127_4366275_29 PFAM Archease protein family (DUF101 UPF0211) - - - 0.000000000000000000000000000000000375 136.0
SHD2_k127_4366275_3 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000804 519.0
SHD2_k127_4366275_30 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000007414 128.0
SHD2_k127_4366275_31 thiolester hydrolase activity - - - 0.00000000000000000000000000003485 123.0
SHD2_k127_4366275_32 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000004691 119.0
SHD2_k127_4366275_33 PFAM CheW domain protein K03408 - - 0.000000000000000000001859 103.0
SHD2_k127_4366275_34 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.000000000000000001956 87.0
SHD2_k127_4366275_35 - - - - 0.00000000001071 73.0
SHD2_k127_4366275_36 PASTA K12132 - 2.7.11.1 0.00000000009781 71.0
SHD2_k127_4366275_37 transferase activity, transferring glycosyl groups - - - 0.000000001134 65.0
SHD2_k127_4366275_38 - - - - 0.000003728 54.0
SHD2_k127_4366275_39 Lipopolysaccharide-assembly, LptC-related - - - 0.0000917 51.0
SHD2_k127_4366275_4 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005879 523.0
SHD2_k127_4366275_5 Response regulator receiver modulated diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 491.0
SHD2_k127_4366275_6 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009476 463.0
SHD2_k127_4366275_7 Protein of unknown function (DUF512) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 447.0
SHD2_k127_4366275_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007118 447.0
SHD2_k127_4366275_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 373.0
SHD2_k127_4384057_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1026.0
SHD2_k127_4384057_1 spermidine synthase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 511.0
SHD2_k127_4384057_10 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000001188 83.0
SHD2_k127_4384057_11 Cytochrome c K12263 - - 0.0000000000000001945 85.0
SHD2_k127_4384057_12 Protein of unknown function (DUF1573) - - - 0.00004129 48.0
SHD2_k127_4384057_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 362.0
SHD2_k127_4384057_3 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 346.0
SHD2_k127_4384057_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000005073 268.0
SHD2_k127_4384057_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000282 249.0
SHD2_k127_4384057_6 Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.0000000000000000000000000000000001204 141.0
SHD2_k127_4384057_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000006067 122.0
SHD2_k127_4384057_8 PFAM Rubredoxin-type Fe(Cys)4 protein - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592 - 0.000000000000000000000001011 104.0
SHD2_k127_4384057_9 NusG domain II K00805 - 2.5.1.30 0.000000000000000002261 89.0
SHD2_k127_4403610_0 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005884 516.0
SHD2_k127_4403610_1 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000000003059 144.0
SHD2_k127_4403610_2 PFAM thiamineS protein - - - 0.00000000000007439 73.0
SHD2_k127_4403610_3 Rhodanese-like domain - - - 0.0000000001154 64.0
SHD2_k127_4435797_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1250.0
SHD2_k127_4435797_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.697e-214 671.0
SHD2_k127_4435797_10 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 328.0
SHD2_k127_4435797_11 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 325.0
SHD2_k127_4435797_12 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007222 276.0
SHD2_k127_4435797_13 PFAM oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002373 272.0
SHD2_k127_4435797_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008401 250.0
SHD2_k127_4435797_15 amine dehydrogenase activity K15864,K19345 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.7.2.1,1.7.99.1 0.0000000000000000000000000000000000000000000000000000000000000000004342 243.0
SHD2_k127_4435797_16 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000001609 220.0
SHD2_k127_4435797_17 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000001531 224.0
SHD2_k127_4435797_18 ferrous iron binding K06990,K09141 - - 0.000000000000000000000000000000000000000000000000000000000006399 216.0
SHD2_k127_4435797_19 - - - - 0.0000000000000000000000000000000000000000000000000000006908 202.0
SHD2_k127_4435797_2 Fructose-bisphosphate aldolase class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 610.0
SHD2_k127_4435797_20 Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11783 - 3.2.2.26 0.000000000000000000000000000000000000000000000000000001304 201.0
SHD2_k127_4435797_21 PFAM Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000001231 177.0
SHD2_k127_4435797_22 membrane K00389 - - 0.0000000000000000000000000000000000000000009925 161.0
SHD2_k127_4435797_23 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000008392 148.0
SHD2_k127_4435797_24 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000001226 150.0
SHD2_k127_4435797_25 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000008491 128.0
SHD2_k127_4435797_26 redox protein regulator of disulfide bond formation K07397 - - 0.00000000000000000002749 96.0
SHD2_k127_4435797_28 heat shock protein binding K03686 - - 0.0000000002635 73.0
SHD2_k127_4435797_3 PFAM natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 527.0
SHD2_k127_4435797_30 transporter antisigma-factor antagonist STAS K03321 - - 0.0000000008426 60.0
SHD2_k127_4435797_31 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000003172 49.0
SHD2_k127_4435797_4 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007324 449.0
SHD2_k127_4435797_5 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 445.0
SHD2_k127_4435797_6 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 403.0
SHD2_k127_4435797_7 MgtE intracellular N domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 389.0
SHD2_k127_4435797_8 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 365.0
SHD2_k127_4435797_9 Polyprenyl synthetase K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006185 342.0
SHD2_k127_4469554_0 CAAX prenyl protease N-terminal, five membrane helices - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 415.0
SHD2_k127_4469554_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 353.0
SHD2_k127_4469554_2 peptidyl-prolyl cis-trans isomerase - - - 0.00000000000000000000000000000000000003217 147.0
SHD2_k127_4469554_3 Tetratricopeptide repeat - - - 0.000000000000000005125 93.0
SHD2_k127_4493173_0 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 462.0
SHD2_k127_4493173_1 Methylenetetrahydrofolate reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 298.0
SHD2_k127_4493173_10 COG2203 FOG GAF domain - - - 0.000005777 57.0
SHD2_k127_4493173_11 4Fe-4S binding domain - - - 0.00004165 46.0
SHD2_k127_4493173_12 Major Facilitator Superfamily - - - 0.0004424 45.0
SHD2_k127_4493173_2 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009582 252.0
SHD2_k127_4493173_3 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003146 248.0
SHD2_k127_4493173_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001832 254.0
SHD2_k127_4493173_5 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.00000000000000000000000000000000000000000000000000000000000001843 223.0
SHD2_k127_4493173_6 - - - - 0.000000000000000000000000000000000000000000000000000000003342 207.0
SHD2_k127_4493173_7 Type I restriction enzyme R protein N terminus (HSDR_N) - - - 0.000000000000000000000000000000000000000000001369 171.0
SHD2_k127_4493173_8 Histidine kinase A domain protein K01768 - 4.6.1.1 0.000000000000000000000000000000000000000003026 167.0
SHD2_k127_4493173_9 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000005069 48.0
SHD2_k127_45224_0 von Willebrand factor, type A K07114 - - 2.9e-312 973.0
SHD2_k127_45224_1 Putative Fe-S cluster K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 333.0
SHD2_k127_45224_2 Part of a membrane complex involved in electron transport K03617 - - 0.000000000000000000000000000000000000000000000000000000000000000006904 230.0
SHD2_k127_45224_3 Part of a membrane complex involved in electron transport K03613 - - 0.0000000000000000000000000000000000000000000000000000001024 203.0
SHD2_k127_45224_4 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000006454 168.0
SHD2_k127_45224_5 Part of a membrane complex involved in electron transport K03612 - - 0.0000000000000000000000001682 114.0
SHD2_k127_4558207_1 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 496.0
SHD2_k127_4558207_10 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.00000003119 59.0
SHD2_k127_4558207_2 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000000000003893 163.0
SHD2_k127_4558207_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000001206 137.0
SHD2_k127_4558207_4 YceI-like domain - - - 0.0000000000000000000000000003708 119.0
SHD2_k127_4558207_5 - - - - 0.0000000000000000000000000005855 120.0
SHD2_k127_4558207_6 protein complex oligomerization - - - 0.000000000000000000000008235 107.0
SHD2_k127_4558207_7 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000000000000000002622 102.0
SHD2_k127_4558207_8 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.000000000000004737 81.0
SHD2_k127_4558207_9 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00000001363 59.0
SHD2_k127_4569833_0 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 452.0
SHD2_k127_4569833_1 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 398.0
SHD2_k127_4569833_2 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 349.0
SHD2_k127_4569833_3 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000004338 179.0
SHD2_k127_4569833_4 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000000000001541 131.0
SHD2_k127_4569833_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000003844 70.0
SHD2_k127_4569833_6 histidine kinase HAMP region domain protein - - - 0.00000000007469 64.0
SHD2_k127_4578680_0 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 336.0
SHD2_k127_4578680_1 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000008982 213.0
SHD2_k127_4578680_2 nucleotide metabolic process - - - 0.0000000000000000000000000000000000000031 155.0
SHD2_k127_4603408_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009092 559.0
SHD2_k127_4603408_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000004207 214.0
SHD2_k127_4603408_10 Zn-ribbon protein possibly nucleic acid-binding - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00006791 54.0
SHD2_k127_4603408_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000005622 202.0
SHD2_k127_4603408_3 arabinan catabolic process K06113 - 3.2.1.99 0.00000000000000000000000000000000000000000001159 175.0
SHD2_k127_4603408_4 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.0000000000000000001185 93.0
SHD2_k127_4603408_5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000002287 80.0
SHD2_k127_4603408_6 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000001389 53.0
SHD2_k127_4603408_7 - - - - 0.0000002632 52.0
SHD2_k127_4603408_8 Evidence 5 No homology to any previously reported sequences - - - 0.00000152 50.0
SHD2_k127_4610140_0 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 436.0
SHD2_k127_4610140_1 PFAM Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001732 234.0
SHD2_k127_4610140_2 Protein of unknown function, DUF480 K09915 - - 0.000000000000000000000000000000000000000000000000000000000008761 214.0
SHD2_k127_4610140_3 GAF domain K02482 - 2.7.13.3 0.0000000005986 61.0
SHD2_k127_4636859_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 514.0
SHD2_k127_4636859_1 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000000000002683 193.0
SHD2_k127_4636859_2 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000002716 113.0
SHD2_k127_4636859_3 - - - - 0.000005398 56.0
SHD2_k127_46535_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 3.722e-203 641.0
SHD2_k127_46535_1 Amino acid kinase family K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 367.0
SHD2_k127_46535_2 Formylmethanofuran dehydrogenase, subunit e K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000004458 233.0
SHD2_k127_46535_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000004659 230.0
SHD2_k127_46535_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000004385 201.0
SHD2_k127_4655066_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2108.0
SHD2_k127_4655066_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1878.0
SHD2_k127_4655066_10 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001661 259.0
SHD2_k127_4655066_11 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001859 259.0
SHD2_k127_4655066_12 Psort location Cytoplasmic, score 8.96 K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006174 253.0
SHD2_k127_4655066_13 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000001011 212.0
SHD2_k127_4655066_14 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000004117 205.0
SHD2_k127_4655066_15 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000000004311 197.0
SHD2_k127_4655066_16 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000009633 212.0
SHD2_k127_4655066_17 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000004536 187.0
SHD2_k127_4655066_18 denitrification pathway - - - 0.0000000000000000000000000000000000000001753 162.0
SHD2_k127_4655066_19 12 heme-binding sites - - - 0.00000000000000000000000000000000000004504 153.0
SHD2_k127_4655066_2 Surface antigen K07277 - - 6.844e-260 823.0
SHD2_k127_4655066_20 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000004171 143.0
SHD2_k127_4655066_21 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000003657 128.0
SHD2_k127_4655066_22 protein kinase activity - - - 0.000000000000000000000000008558 118.0
SHD2_k127_4655066_23 PFAM outer membrane chaperone Skp (OmpH) K06142 - - 0.0000000000000000000004758 102.0
SHD2_k127_4655066_24 Ribosomal protein L33 K02913 - - 0.0000000000002434 72.0
SHD2_k127_4655066_25 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000005997 70.0
SHD2_k127_4655066_26 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000008385 50.0
SHD2_k127_4655066_3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 2.551e-230 716.0
SHD2_k127_4655066_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 580.0
SHD2_k127_4655066_5 phosphorelay signal transduction system K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 428.0
SHD2_k127_4655066_6 Nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 402.0
SHD2_k127_4655066_7 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 390.0
SHD2_k127_4655066_8 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 364.0
SHD2_k127_4655066_9 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 337.0
SHD2_k127_4675264_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 359.0
SHD2_k127_4675264_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 338.0
SHD2_k127_4675264_2 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009526 293.0
SHD2_k127_4675264_3 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000004572 231.0
SHD2_k127_4675264_4 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000000003502 133.0
SHD2_k127_4675264_5 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000003336 124.0
SHD2_k127_4700042_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008453 572.0
SHD2_k127_4700042_1 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 499.0
SHD2_k127_4700042_2 Haloacid dehalogenase domain protein hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000114 227.0
SHD2_k127_4700042_3 Lipoate-protein ligase K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.00000000000000000000000000000000000000000000002644 179.0
SHD2_k127_4700042_4 Preprotein translocase subunit K03210 - - 0.00000000000001008 75.0
SHD2_k127_4731039_0 O-methyltransferase activity - - - 2.077e-208 667.0
SHD2_k127_4731039_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 1.103e-204 646.0
SHD2_k127_4731039_10 LysM domain - - - 0.00000000000000000000000000000000000006823 155.0
SHD2_k127_4731039_11 PFAM Protein-tyrosine phosphatase, low molecular weight K01104,K20201 - 3.1.3.48,3.9.1.2 0.00000000000000000000000000891 115.0
SHD2_k127_4731039_12 Type I restriction enzyme R protein N terminus (HSDR_N) - - - 0.00000000000000000000000001248 117.0
SHD2_k127_4731039_2 Thiamine pyrophosphate enzyme, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 578.0
SHD2_k127_4731039_3 4 iron, 4 sulfur cluster binding K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 428.0
SHD2_k127_4731039_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000659 442.0
SHD2_k127_4731039_5 binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001132 261.0
SHD2_k127_4731039_6 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000001224 209.0
SHD2_k127_4731039_7 lyase activity - - - 0.00000000000000000000000000000000000000000000000000000001973 203.0
SHD2_k127_4731039_8 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000005806 197.0
SHD2_k127_4731039_9 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000004961 154.0
SHD2_k127_474387_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 574.0
SHD2_k127_474387_1 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004134 268.0
SHD2_k127_474387_2 Chalcone and stilbene synthases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008752 272.0
SHD2_k127_474387_3 - - - - 0.000000000000000000000000000000000000000000000000000005719 209.0
SHD2_k127_474387_4 - - - - 0.000000000000000000000000000000000000005054 151.0
SHD2_k127_474387_6 Cytochrome c - - - 0.0000000000000000002246 102.0
SHD2_k127_474387_7 PFAM Cytochrome C - - - 0.0001663 49.0
SHD2_k127_4748752_0 Succinyl-CoA ligase like flavodoxin domain K01905,K22224 - 6.2.1.13 7.817e-253 797.0
SHD2_k127_4748752_1 GTP-binding GTPase Middle Region K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 616.0
SHD2_k127_4748752_10 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000001176 226.0
SHD2_k127_4748752_11 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000008022 203.0
SHD2_k127_4748752_12 Erythromycin esterase K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000001149 201.0
SHD2_k127_4748752_13 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000001979 166.0
SHD2_k127_4748752_14 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.0001665 45.0
SHD2_k127_4748752_2 PFAM Radical SAM domain protein K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 593.0
SHD2_k127_4748752_3 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007302 580.0
SHD2_k127_4748752_4 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008911 466.0
SHD2_k127_4748752_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 459.0
SHD2_k127_4748752_6 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 436.0
SHD2_k127_4748752_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 433.0
SHD2_k127_4748752_8 belongs to the CobB CobQ family K06873 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 318.0
SHD2_k127_4748752_9 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 291.0
SHD2_k127_4770_0 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 537.0
SHD2_k127_4770_1 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 464.0
SHD2_k127_4770_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.000000000000000000000000000000000000000000000000004688 187.0
SHD2_k127_4770_3 Cold shock K03704 - - 0.000000000000000000000003942 102.0
SHD2_k127_4845024_0 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 331.0
SHD2_k127_4845024_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006864 258.0
SHD2_k127_4845024_3 UPF0182 protein K09118 - - 0.000000000000000000000000000000000000000000000000001975 198.0
SHD2_k127_4845024_4 Belongs to the universal stress protein A family - - - 0.000000000000000000000000004146 117.0
SHD2_k127_4845024_5 Transglycosylase SLT domain - - - 0.00000000008827 71.0
SHD2_k127_4845024_6 Protein of unknown function (DUF2934) - - - 0.00001029 52.0
SHD2_k127_4851840_0 Belongs to the aldehyde dehydrogenase family K13821 - 1.2.1.88,1.5.5.2 0.0 1078.0
SHD2_k127_4851840_1 DoxX K15977 - - 0.0000000000000000000000000000000000000000000000000000002367 197.0
SHD2_k127_4851840_2 NAD dependent epimerase dehydratase family protein - - - 0.0000000000000000000000000000000485 138.0
SHD2_k127_4851840_3 hydrolase, family 3 K01207 - 3.2.1.52 0.000000000000000000000000000008037 130.0
SHD2_k127_4851840_4 Cold shock K03704 - - 0.00000000000000000000000003491 108.0
SHD2_k127_4851840_5 Homologous to orf229 gp Streptococcus thermophilus bacteriophage Sfi19 gi 9632919 ref NP_049948.1 - - - 0.000000000000000008735 89.0
SHD2_k127_4886564_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 562.0
SHD2_k127_4886564_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 449.0
SHD2_k127_4886564_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000004399 141.0
SHD2_k127_4886564_3 Bacterial membrane protein YfhO - - - 0.0001414 51.0
SHD2_k127_4890138_0 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 5.444e-243 763.0
SHD2_k127_4890138_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 2.769e-198 631.0
SHD2_k127_4890138_2 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 481.0
SHD2_k127_4890138_3 NhaP-type Na H and K H antiporters with a unique C-terminal domain K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 417.0
SHD2_k127_4890138_4 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000025 171.0
SHD2_k127_4890138_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000008979 121.0
SHD2_k127_4890138_6 - - - - 0.0002677 44.0
SHD2_k127_4903480_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1700.0
SHD2_k127_4903480_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 1.295e-195 618.0
SHD2_k127_4903480_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 1.432e-194 613.0
SHD2_k127_4903480_3 Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 493.0
SHD2_k127_4903480_4 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000000000024 241.0
SHD2_k127_4903480_5 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000003785 202.0
SHD2_k127_4903480_6 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000002218 124.0
SHD2_k127_4903480_7 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000002491 125.0
SHD2_k127_4920932_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.911e-286 893.0
SHD2_k127_4920932_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.974e-223 700.0
SHD2_k127_4920932_2 cobalt ion transport K02007,K02009,K16915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 397.0
SHD2_k127_4920932_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 324.0
SHD2_k127_4920932_4 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001773 276.0
SHD2_k127_4920932_5 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004303 252.0
SHD2_k127_4920932_6 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000006302 183.0
SHD2_k127_4920932_7 MgtC family K07507 - - 0.0000000000000000000000000000000001116 140.0
SHD2_k127_4920932_8 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000000002694 132.0
SHD2_k127_4920932_9 DNA-damage-inducible protein d K14623 - - 0.000000000000000000000007657 102.0
SHD2_k127_4971219_0 Bacterial regulatory protein, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006053 532.0
SHD2_k127_4971219_1 GHKL domain K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 516.0
SHD2_k127_4971219_10 Transcription factor zinc-finger - - - 0.000000000000000000028 100.0
SHD2_k127_4971219_11 Glucose / Sorbosone dehydrogenase - - - 0.0000000000415 64.0
SHD2_k127_4971219_12 PAS fold - - - 0.00001756 47.0
SHD2_k127_4971219_2 Phosphonate ABC transporter, periplasmic K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 352.0
SHD2_k127_4971219_3 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002064 266.0
SHD2_k127_4971219_4 Pas domain s-box - - - 0.000000000000000000000000000000000000000000000000000000000000000000002393 256.0
SHD2_k127_4971219_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000616 241.0
SHD2_k127_4971219_6 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000000007944 167.0
SHD2_k127_4971219_7 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000007043 162.0
SHD2_k127_4971219_9 Phosphoribosyl-AMP cyclohydrolase K01496,K01497,K01523,K01814,K11755 GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16 0.0000000000000000000000004278 107.0
SHD2_k127_4979904_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.847e-227 715.0
SHD2_k127_4979904_1 Evidence 2b Function of strongly homologous gene - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 544.0
SHD2_k127_4979904_10 Tetratricopeptide repeat protein - - - 0.0001641 52.0
SHD2_k127_4979904_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009524 525.0
SHD2_k127_4979904_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 524.0
SHD2_k127_4979904_4 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 366.0
SHD2_k127_4979904_5 Large family of predicted nucleotide-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 333.0
SHD2_k127_4979904_6 zinc ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006648 271.0
SHD2_k127_4979904_7 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000003758 160.0
SHD2_k127_4979904_8 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000004805 158.0
SHD2_k127_4979904_9 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000003129 97.0
SHD2_k127_5044249_0 Methyl-viologen-reducing hydrogenase, delta subunit K16886 - - 8.479e-306 955.0
SHD2_k127_5044249_1 FAD dependent oxidoreductase K16885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 596.0
SHD2_k127_5044249_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 454.0
SHD2_k127_5044249_3 nitrate reductase activity K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 402.0
SHD2_k127_5044249_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000001805 108.0
SHD2_k127_5044249_5 reductase, alpha subunit K00394 - 1.8.99.2 0.000000000000579 68.0
SHD2_k127_504776_0 - K07112 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000001651 206.0
SHD2_k127_504776_1 Cytochrome c K08738 - - 0.0000000000000051 78.0
SHD2_k127_504776_2 Universal stress protein family - - - 0.00000000003119 71.0
SHD2_k127_504776_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000003034 64.0
SHD2_k127_504776_4 Universal stress protein family - - - 0.0000001167 60.0
SHD2_k127_5049540_0 Belongs to the peptidase S8 family - - - 5.614e-197 629.0
SHD2_k127_5049540_1 PFAM UBA THIF-type NAD FAD binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 380.0
SHD2_k127_5049540_2 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000002238 201.0
SHD2_k127_5049540_3 Secretion protein K01993 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.000000000000000000000255 109.0
SHD2_k127_5049540_4 Outer membrane efflux protein - - - 0.000000000007241 78.0
SHD2_k127_5049540_5 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0009165 42.0
SHD2_k127_50919_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 309.0
SHD2_k127_50919_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001438 267.0
SHD2_k127_50919_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000003005 252.0
SHD2_k127_50919_3 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000005658 240.0
SHD2_k127_50919_4 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003346 222.0
SHD2_k127_50919_5 PBP superfamily domain K02040 - - 0.000000000000000000000000000000000000000000000000000000009199 205.0
SHD2_k127_5147195_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.559e-222 728.0
SHD2_k127_5147195_1 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 533.0
SHD2_k127_5147195_10 - - - - 0.00000000001683 72.0
SHD2_k127_5147195_11 curli production assembly transport component CsgG - - - 0.0000009282 62.0
SHD2_k127_5147195_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 424.0
SHD2_k127_5147195_3 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 356.0
SHD2_k127_5147195_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 316.0
SHD2_k127_5147195_5 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000003132 262.0
SHD2_k127_5147195_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000000000000000005945 213.0
SHD2_k127_5147195_7 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000002706 205.0
SHD2_k127_5147195_8 Belongs to the Nudix hydrolase family - - - 0.00000000000000000000000000000000004125 138.0
SHD2_k127_5147195_9 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000003189 127.0
SHD2_k127_516637_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 354.0
SHD2_k127_516637_1 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008592 244.0
SHD2_k127_516637_2 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000002838 197.0
SHD2_k127_516637_3 - - - - 0.0000000000000000000000000000000004247 134.0
SHD2_k127_5294790_0 Domains REC, sigma54 interaction, HTH8 K02481 - - 2.14e-206 650.0
SHD2_k127_5294790_1 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 596.0
SHD2_k127_5294790_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 526.0
SHD2_k127_5294790_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 493.0
SHD2_k127_5294790_4 PEP-CTERM exosortase 1-associated glycosyltransferase, Daro_2409 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 403.0
SHD2_k127_5294790_5 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 397.0
SHD2_k127_5294790_6 eight transmembrane protein EpsH - - - 0.000000000000000000000000000000000000000000000000000000000000000000003016 245.0
SHD2_k127_5294790_7 Protein of unknown function (DUF3485) - - - 0.000000000000000000000000000000000000165 149.0
SHD2_k127_5294790_8 Methyltransferase domain - - - 0.000000000000000000000000000001362 129.0
SHD2_k127_5305113_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1406.0
SHD2_k127_5305113_1 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 487.0
SHD2_k127_5305113_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 432.0
SHD2_k127_5305113_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 381.0
SHD2_k127_5305113_4 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000000000001801 147.0
SHD2_k127_5305113_5 Catalyzes the reduction of arsenate As(V) to arsenite As(III) K03741 - 1.20.4.1 0.000000000000000000000000001247 114.0
SHD2_k127_5305113_6 cell redox homeostasis - - - 0.000000000000000000000007467 102.0
SHD2_k127_5305113_7 Membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.0000000000000000611 81.0
SHD2_k127_5305113_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000005985 74.0
SHD2_k127_5305113_9 redox protein regulator of disulfide bond formation K07397 - - 0.0006317 43.0
SHD2_k127_5311290_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.229e-295 915.0
SHD2_k127_5311290_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 5.536e-262 820.0
SHD2_k127_5311290_10 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 315.0
SHD2_k127_5311290_11 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 313.0
SHD2_k127_5311290_12 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004594 310.0
SHD2_k127_5311290_13 PFAM CheW domain protein K03408 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000469 258.0
SHD2_k127_5311290_14 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001215 260.0
SHD2_k127_5311290_15 Chemotaxis sensory transducer - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007037 269.0
SHD2_k127_5311290_16 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002939 247.0
SHD2_k127_5311290_17 Response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000002436 203.0
SHD2_k127_5311290_18 PFAM response regulator receiver K03413 - - 0.0000000000000000000000000000000000000000000000000001737 187.0
SHD2_k127_5311290_19 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000007249 196.0
SHD2_k127_5311290_2 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 1.513e-229 733.0
SHD2_k127_5311290_20 nuclease K00590,K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 2.1.1.113,3.1.31.1 0.00000000000000000000000000000000000000000003027 170.0
SHD2_k127_5311290_21 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000000006926 151.0
SHD2_k127_5311290_22 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000000000313 135.0
SHD2_k127_5311290_23 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.000000000000000000001058 108.0
SHD2_k127_5311290_24 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000002417 88.0
SHD2_k127_5311290_25 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000001639 78.0
SHD2_k127_5311290_26 Sporulation and spore germination - - - 0.00000000000002662 80.0
SHD2_k127_5311290_27 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000008578 75.0
SHD2_k127_5311290_29 STAS domain - - - 0.0000003198 59.0
SHD2_k127_5311290_3 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 2.524e-214 676.0
SHD2_k127_5311290_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 541.0
SHD2_k127_5311290_5 histidine kinase HAMP region domain protein K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 538.0
SHD2_k127_5311290_6 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K11384 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 440.0
SHD2_k127_5311290_7 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 370.0
SHD2_k127_5311290_8 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 368.0
SHD2_k127_5311290_9 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 351.0
SHD2_k127_5314285_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 528.0
SHD2_k127_5314285_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 447.0
SHD2_k127_5314285_2 diguanylate cyclase - - - 0.000000000000000000000000000000004773 147.0
SHD2_k127_5314285_3 PBP superfamily domain K02040 - - 0.00000000000000000000000000003689 121.0
SHD2_k127_5320369_0 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 366.0
SHD2_k127_5320369_1 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 341.0
SHD2_k127_5320369_2 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 295.0
SHD2_k127_5320369_3 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002824 275.0
SHD2_k127_5320369_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000005954 256.0
SHD2_k127_5320369_5 GGDEF domain - - - 0.000000000000000000000000000000000000000000000003533 190.0
SHD2_k127_5320369_6 4Fe-4S binding domain - - - 0.00000000000000000000000000000000005967 135.0
SHD2_k127_5320369_7 - - - - 0.000000000000000000000001453 106.0
SHD2_k127_5320369_8 toxin-antitoxin pair type II binding - - - 0.000000000000000000001226 97.0
SHD2_k127_5320369_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system - - - 0.000000000001182 70.0
SHD2_k127_5330434_0 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006688 519.0
SHD2_k127_5330434_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 396.0
SHD2_k127_5330434_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 396.0
SHD2_k127_5330434_3 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004262 301.0
SHD2_k127_5330434_4 membrane K09133 - - 0.0000000000000000000000143 104.0
SHD2_k127_5351738_0 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003149 497.0
SHD2_k127_5351738_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000007499 103.0
SHD2_k127_5351738_2 Psort location CytoplasmicMembrane, score - - - 0.0000000000000003179 89.0
SHD2_k127_5363255_0 Aminotransferase class I and II K14261 - - 6.437e-213 670.0
SHD2_k127_5363255_1 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 601.0
SHD2_k127_5363255_10 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000001497 202.0
SHD2_k127_5363255_11 Nitroreductase family - - - 0.000000000000000000000000000000006757 136.0
SHD2_k127_5363255_12 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000004163 134.0
SHD2_k127_5363255_13 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000000007043 119.0
SHD2_k127_5363255_14 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000001245 107.0
SHD2_k127_5363255_15 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00004249 47.0
SHD2_k127_5363255_2 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 539.0
SHD2_k127_5363255_3 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 411.0
SHD2_k127_5363255_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 331.0
SHD2_k127_5363255_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 329.0
SHD2_k127_5363255_6 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000893 250.0
SHD2_k127_5363255_7 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000005932 241.0
SHD2_k127_5363255_8 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000001146 225.0
SHD2_k127_5363255_9 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000001234 210.0
SHD2_k127_5375789_0 Belongs to the peptidase S16 family K01338,K04076 - 3.4.21.53 0.0 1066.0
SHD2_k127_5375789_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.227e-213 672.0
SHD2_k127_5375789_2 Metallo-beta-lactamase superfamily K22405 - 1.6.3.4 6.323e-199 625.0
SHD2_k127_5375789_3 CoA binding domain K09181 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 514.0
SHD2_k127_5375789_4 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 484.0
SHD2_k127_5375789_5 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 302.0
SHD2_k127_5375789_6 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002627 259.0
SHD2_k127_5375789_7 PFAM lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000002306 243.0
SHD2_k127_5375789_8 radical SAM K06871 - - 0.000000000000000000000000000000000000000001627 169.0
SHD2_k127_5398516_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1095.0
SHD2_k127_5398516_1 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 394.0
SHD2_k127_5398516_10 - - - - 0.00000002491 55.0
SHD2_k127_5398516_11 response regulator - - - 0.0004828 44.0
SHD2_k127_5398516_2 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 298.0
SHD2_k127_5398516_3 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003094 259.0
SHD2_k127_5398516_4 TPM domain - - - 0.000000000000000000000000000000000000000000000000000249 192.0
SHD2_k127_5398516_5 Domain of unknown function (DUF2703) - - - 0.000000000000000000000000000000000000000000000000002529 184.0
SHD2_k127_5398516_6 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000000000004668 138.0
SHD2_k127_5398516_7 copG family - - - 0.0000000000000000000000000000000001559 134.0
SHD2_k127_5398516_9 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000001122 73.0
SHD2_k127_5407151_0 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 457.0
SHD2_k127_5407151_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000001208 259.0
SHD2_k127_5407151_2 DivIVA protein K04074 - - 0.0000000000000000000000000000000000000000000000000000000000008191 213.0
SHD2_k127_5407151_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000004184 213.0
SHD2_k127_5407151_4 YGGT family K02221 - - 0.00000000000000000000000000000003085 129.0
SHD2_k127_5407504_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1156.0
SHD2_k127_5407504_1 C oxidoreductase subunit A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006092 423.0
SHD2_k127_5407504_10 Cytochrome c - - - 0.00000000000000004175 84.0
SHD2_k127_5407504_11 - - - - 0.0000000000003197 72.0
SHD2_k127_5407504_2 Protein of unknown function (DUF3443) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 420.0
SHD2_k127_5407504_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002069 289.0
SHD2_k127_5407504_4 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000002418 193.0
SHD2_k127_5407504_5 Protein of unknown function (DUF2844) - - - 0.000000000000000000000000000000000000000000002954 168.0
SHD2_k127_5407504_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000003713 168.0
SHD2_k127_5407504_7 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.00000000000000000000000000000000000000003144 153.0
SHD2_k127_5407504_8 PFAM Cold-shock protein DNA-binding K03704 - - 0.000000000000000000000003755 104.0
SHD2_k127_5407504_9 Ribbon-helix-helix protein, copG family - - - 0.00000000000000000000839 93.0
SHD2_k127_5439618_0 Heat shock 70 kDa protein K04043 - - 0.0 1020.0
SHD2_k127_5439618_1 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 492.0
SHD2_k127_5439618_10 DJ-1/PfpI family K03152 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001949 269.0
SHD2_k127_5439618_11 PFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000001438 252.0
SHD2_k127_5439618_12 SEC-C motif K09858 - - 0.0000000000000000000000000000000000000000000000000000000000001846 216.0
SHD2_k127_5439618_13 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000001421 220.0
SHD2_k127_5439618_14 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000004496 183.0
SHD2_k127_5439618_15 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000007014 149.0
SHD2_k127_5439618_16 PFAM DAHP synthetase I KDSA K03856,K04516 - 2.5.1.54,5.4.99.5 0.0000000000000000611 81.0
SHD2_k127_5439618_17 His Kinase A (phosphoacceptor - - - 0.00000000009317 73.0
SHD2_k127_5439618_18 integral membrane protein - - - 0.000001125 61.0
SHD2_k127_5439618_19 PFAM amino acid-binding ACT domain protein - - - 0.00002906 52.0
SHD2_k127_5439618_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 480.0
SHD2_k127_5439618_3 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 448.0
SHD2_k127_5439618_4 spermidine synthase activity K00797 GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 417.0
SHD2_k127_5439618_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 417.0
SHD2_k127_5439618_6 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 375.0
SHD2_k127_5439618_7 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 356.0
SHD2_k127_5439618_8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002922 308.0
SHD2_k127_5439618_9 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 291.0
SHD2_k127_5449992_0 PFAM peptidase K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 408.0
SHD2_k127_5449992_1 Mur ligase family, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007405 312.0
SHD2_k127_5449992_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000001016 208.0
SHD2_k127_5449992_3 - - - - 0.000000000000000000000001635 106.0
SHD2_k127_5449992_4 Transcriptional regulator - - - 0.00000000000000000000001347 104.0
SHD2_k127_5449992_5 - - - - 0.0001754 45.0
SHD2_k127_5458341_0 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 386.0
SHD2_k127_5458341_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 396.0
SHD2_k127_5458341_2 Cys/Met metabolism PLP-dependent enzyme K01760,K01761 - 4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006884 370.0
SHD2_k127_5458341_3 Transcriptional regulator K02019,K05772 - - 0.000000000000000000000000000000002206 136.0
SHD2_k127_5458341_4 PFAM 4Fe-4S K00176 - 1.2.7.3 0.00000000000000000003779 92.0
SHD2_k127_5458341_5 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000002079 64.0
SHD2_k127_550566_0 PFAM nickel-dependent hydrogenase large subunit K00436,K14126 - 1.12.1.2,1.8.98.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 598.0
SHD2_k127_550566_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006005 464.0
SHD2_k127_550566_2 PFAM Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 416.0
SHD2_k127_550566_3 Oxidoreductase FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 406.0
SHD2_k127_550566_4 NADH ubiquinone oxidoreductase 20 kDa subunit K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 361.0
SHD2_k127_550566_5 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.0000000000000000000000000003727 118.0
SHD2_k127_550566_6 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.000000000000000000000004397 108.0
SHD2_k127_550566_7 cheY-homologous receiver domain - - - 0.000000000000003391 85.0
SHD2_k127_5534444_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.0 1450.0
SHD2_k127_5534444_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 530.0
SHD2_k127_5534444_10 PFAM ATP-binding region, ATPase-like histidine kinase A-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 319.0
SHD2_k127_5534444_11 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008488 289.0
SHD2_k127_5534444_12 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007351 254.0
SHD2_k127_5534444_13 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000001696 241.0
SHD2_k127_5534444_14 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000002154 199.0
SHD2_k127_5534444_15 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000001077 205.0
SHD2_k127_5534444_16 CO dehydrogenase acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein) - - - 0.000000000000000000000000000000000000000003362 164.0
SHD2_k127_5534444_17 Cytochrome P460 - - - 0.00000000000000000000000000000000000001708 150.0
SHD2_k127_5534444_18 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.0000000000000000000000000001511 128.0
SHD2_k127_5534444_19 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000008341 126.0
SHD2_k127_5534444_2 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 475.0
SHD2_k127_5534444_20 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000001012 113.0
SHD2_k127_5534444_21 cheY-homologous receiver domain - - - 0.000000000000000000000794 99.0
SHD2_k127_5534444_22 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.000000000000000000003187 109.0
SHD2_k127_5534444_24 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000001004 98.0
SHD2_k127_5534444_26 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000974 62.0
SHD2_k127_5534444_27 YbbR-like protein - - - 0.00002947 55.0
SHD2_k127_5534444_28 PilZ domain - - - 0.00003278 52.0
SHD2_k127_5534444_29 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00003734 55.0
SHD2_k127_5534444_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000629 399.0
SHD2_k127_5534444_4 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 389.0
SHD2_k127_5534444_5 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 404.0
SHD2_k127_5534444_6 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 357.0
SHD2_k127_5534444_7 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 351.0
SHD2_k127_5534444_8 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 323.0
SHD2_k127_5534444_9 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 321.0
SHD2_k127_5540206_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 4.178e-311 960.0
SHD2_k127_5540206_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.834e-244 765.0
SHD2_k127_5540206_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 421.0
SHD2_k127_5540206_3 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 370.0
SHD2_k127_5540206_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000003442 250.0
SHD2_k127_5634245_0 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 353.0
SHD2_k127_5634245_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 350.0
SHD2_k127_5634245_10 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000004393 150.0
SHD2_k127_5634245_11 Outer membrane lipoprotein - - - 0.000000000000000000000000000000000004449 149.0
SHD2_k127_5634245_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 341.0
SHD2_k127_5634245_3 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 327.0
SHD2_k127_5634245_4 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000008811 238.0
SHD2_k127_5634245_5 cytochrome complex assembly - - - 0.000000000000000000000000000000000000000000000000000000000000000002001 235.0
SHD2_k127_5634245_6 Metal-dependent phosphohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000008287 232.0
SHD2_k127_5634245_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000003722 199.0
SHD2_k127_5634245_8 cytochrome c biogenesis protein - - - 0.000000000000000000000000000000000000000000000000008911 188.0
SHD2_k127_5634245_9 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000004503 171.0
SHD2_k127_572230_0 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 332.0
SHD2_k127_572230_1 PilZ domain - - - 0.0002886 50.0
SHD2_k127_572230_2 PFAM Transposase IS200 like - - - 0.0002926 46.0
SHD2_k127_5798018_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 571.0
SHD2_k127_5798018_1 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001873 285.0
SHD2_k127_5798018_2 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001143 160.0
SHD2_k127_5798018_3 DsrE/DsrF/DrsH-like family - - - 0.00000003307 55.0
SHD2_k127_5804684_0 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 376.0
SHD2_k127_5804684_1 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 286.0
SHD2_k127_5804684_2 Sigma-54 interaction domain K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000001744 204.0
SHD2_k127_584594_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1590.0
SHD2_k127_584594_1 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1493.0
SHD2_k127_584594_10 Outer membrane efflux protein - - - 0.000000000009485 69.0
SHD2_k127_584594_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.654e-207 653.0
SHD2_k127_584594_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 570.0
SHD2_k127_584594_4 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 489.0
SHD2_k127_584594_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 402.0
SHD2_k127_584594_6 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008717 354.0
SHD2_k127_584594_7 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006102 276.0
SHD2_k127_584594_8 PFAM phosphoesterase RecJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002696 237.0
SHD2_k127_584594_9 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000006975 229.0
SHD2_k127_5898446_0 Glycosyl transferase family group 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 318.0
SHD2_k127_5898446_1 glycosyl transferase family 2 K00786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002839 253.0
SHD2_k127_5898446_2 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000002984 149.0
SHD2_k127_5898446_3 Uncharacterized conserved protein (DUF2304) - - - 0.00000000000000000007335 93.0
SHD2_k127_5898446_4 Trypsin-like peptidase domain - - - 0.0000202 58.0
SHD2_k127_5934315_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 428.0
SHD2_k127_5934315_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009839 327.0
SHD2_k127_5934315_2 zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000000000000000422 194.0
SHD2_k127_5934315_3 PFAM Peptidase M16 - - - 0.000000000000000000000000000000000000000000000004201 178.0
SHD2_k127_5934315_4 GyrI-like small molecule binding domain - - - 0.0000000000000000000000000000000000000000000003431 169.0
SHD2_k127_5978247_0 NADH-quinone oxidoreductase K00341 - 1.6.5.3 3.793e-244 769.0
SHD2_k127_5978247_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 610.0
SHD2_k127_5978247_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 454.0
SHD2_k127_5978247_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000001213 203.0
SHD2_k127_5978247_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000004617 160.0
SHD2_k127_5978247_5 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000001336 147.0
SHD2_k127_5978247_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000001099 125.0
SHD2_k127_5991151_0 PFAM Type II secretion system protein E K02454 - - 5.186e-199 631.0
SHD2_k127_5991151_1 Type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 530.0
SHD2_k127_5991151_2 General secretion pathway protein F K02455,K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 300.0
SHD2_k127_5991151_3 SMART Rhodanese domain protein - - - 0.0000000000000000000000000000000000000000000000000000004269 204.0
SHD2_k127_5991151_4 protein transport across the cell outer membrane K02452,K02463 - - 0.00000000000000000000000000000000000003915 154.0
SHD2_k127_5991151_5 SMART Rhodanese domain protein - - - 0.0000000000000000007453 89.0
SHD2_k127_5991151_6 PFAM Phosphate-selective porin O and P - - - 0.000000000005747 72.0
SHD2_k127_6012339_0 Part of the ABC transporter complex PstSACB involved in phosphate import - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003891 271.0
SHD2_k127_6012339_1 SMART ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000195 277.0
SHD2_k127_6012339_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K13039 - 4.1.1.79 0.000000000000000000000000000000000000004531 150.0
SHD2_k127_6033742_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 388.0
SHD2_k127_6033742_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002959 282.0
SHD2_k127_6033742_2 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001454 272.0
SHD2_k127_6033742_3 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000004685 227.0
SHD2_k127_6033742_4 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000002094 167.0
SHD2_k127_6033742_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000001263 151.0
SHD2_k127_6033742_6 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000002695 134.0
SHD2_k127_6033742_7 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000006324 123.0
SHD2_k127_6033742_8 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000001528 99.0
SHD2_k127_6089480_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 534.0
SHD2_k127_6089480_1 alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 429.0
SHD2_k127_6089480_10 - - - - 0.0000000000000001374 82.0
SHD2_k127_6089480_11 ResB-like family K07399 - - 0.00006465 48.0
SHD2_k127_6089480_12 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00074 51.0
SHD2_k127_6089480_2 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 397.0
SHD2_k127_6089480_3 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 367.0
SHD2_k127_6089480_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 293.0
SHD2_k127_6089480_5 - K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003062 272.0
SHD2_k127_6089480_6 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004045 244.0
SHD2_k127_6089480_7 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000005036 192.0
SHD2_k127_6089480_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000009336 164.0
SHD2_k127_6089480_9 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000006242 141.0
SHD2_k127_6100474_0 TIGRFAM ATP-dependent helicase HrpB K03579 - 3.6.4.13 1.4e-235 749.0
SHD2_k127_6100474_1 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 521.0
SHD2_k127_6100474_2 Domain of unknown function (DUF4203) - - - 0.000000000000000000000000001068 118.0
SHD2_k127_6100474_3 - - - - 0.0000000000000000000000003039 109.0
SHD2_k127_6105749_0 Cell shape determining protein MreB Mrl K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 321.0
SHD2_k127_6105749_1 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000001524 175.0
SHD2_k127_6105749_2 Glycosyl transferase family 2 K12992 - - 0.00000000000000000000000000000000000000000003068 184.0
SHD2_k127_6105749_3 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000479 168.0
SHD2_k127_6105749_4 Glycosyltransferase like family 2 K12992 - - 0.0000000000000000000000000000000000001523 152.0
SHD2_k127_6105749_5 PFAM Response regulator receiver domain K07658 - - 0.0000000005128 71.0
SHD2_k127_6167112_0 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000000000000001394 206.0
SHD2_k127_6167112_1 Type II secretion system (T2SS), protein J K02459 - - 0.00000000000000000000000004938 115.0
SHD2_k127_6167112_2 - - - - 0.000000000000000000000003809 112.0
SHD2_k127_6167112_3 Prokaryotic N-terminal methylation motif K02457 - - 0.0000000000000000000001172 104.0
SHD2_k127_6167112_4 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.000000000001145 79.0
SHD2_k127_6167112_5 Prokaryotic N-terminal methylation motif K02458 - - 0.0000000001627 66.0
SHD2_k127_6167112_7 Type II secretion system (T2SS), protein K K02460 - - 0.00000003717 64.0
SHD2_k127_6192090_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.204e-284 883.0
SHD2_k127_6192090_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 594.0
SHD2_k127_6192090_2 ROK family K00845,K13967,K19979,K20433 - 2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000224 266.0
SHD2_k127_6192090_3 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000003451 256.0
SHD2_k127_6192090_4 ABC transporter K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000001108 239.0
SHD2_k127_6192090_5 TIGRFAM riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000003665 220.0
SHD2_k127_6192090_6 Peptidase family M23 K21471 - - 0.000000000000000000000000000000000000000000000000000000000005107 225.0
SHD2_k127_6192090_7 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.00000000000000000000000000003976 128.0
SHD2_k127_6192090_8 Transcriptional regulator, arsR family - - - 0.0000000000000000000000004427 108.0
SHD2_k127_6192090_9 - - - - 0.000000000000000000000008487 108.0
SHD2_k127_61936_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1235.0
SHD2_k127_61936_1 Telomere recombination K04656 - - 3.172e-246 785.0
SHD2_k127_61936_10 PAS domain containing protein K03406,K13924,K14986 - 2.1.1.80,2.7.13.3,3.1.1.61 0.00000000000000000001114 93.0
SHD2_k127_61936_11 - - - - 0.00000000000000001264 88.0
SHD2_k127_61936_12 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000005513 51.0
SHD2_k127_61936_13 Putative zinc- or iron-chelating domain K06940 - - 0.00006468 51.0
SHD2_k127_61936_14 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0004362 43.0
SHD2_k127_61936_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 496.0
SHD2_k127_61936_3 Hydrogenase formation hypA family K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 453.0
SHD2_k127_61936_4 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 369.0
SHD2_k127_61936_5 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 322.0
SHD2_k127_61936_6 TIGRFAM peptidase T-like protein K01258 - 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005671 286.0
SHD2_k127_61936_7 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001075 252.0
SHD2_k127_61936_8 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000000000000000000000000000000249 192.0
SHD2_k127_61936_9 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000004414 114.0
SHD2_k127_6353721_0 Sigma-54 interaction domain - - - 1.649e-242 761.0
SHD2_k127_6353721_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 402.0
SHD2_k127_6353721_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008981 371.0
SHD2_k127_6365505_0 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 0.0 1064.0
SHD2_k127_6365505_1 2-methylcitrate dehydratase K01720 - 4.2.1.79 5.455e-251 782.0
SHD2_k127_6365505_2 also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity K01659 - 2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 572.0
SHD2_k127_6365505_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841,K03417 - 4.1.3.30,5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 455.0
SHD2_k127_6365505_4 Protein of unknown function (DUF3187) - - - 0.000000000000000000000001745 115.0
SHD2_k127_6370239_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 4.268e-247 776.0
SHD2_k127_6370239_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 589.0
SHD2_k127_6370239_2 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 472.0
SHD2_k127_6387475_0 ABC transporter K06020 - 3.6.3.25 4.921e-310 955.0
SHD2_k127_6387475_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 550.0
SHD2_k127_6387475_10 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000005539 199.0
SHD2_k127_6387475_11 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.0000000000000000000000000000000000000000000000006794 184.0
SHD2_k127_6387475_12 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000000000003885 119.0
SHD2_k127_6387475_13 DNA-binding transcription factor activity K03655,K03892,K21903 - 3.6.4.12 0.00000000000000000006927 93.0
SHD2_k127_6387475_14 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000001513 59.0
SHD2_k127_6387475_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 527.0
SHD2_k127_6387475_3 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 523.0
SHD2_k127_6387475_4 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 446.0
SHD2_k127_6387475_5 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 335.0
SHD2_k127_6387475_6 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 333.0
SHD2_k127_6387475_7 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 325.0
SHD2_k127_6387475_8 Methylene-tetrahydrofolate reductase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006363 287.0
SHD2_k127_6387475_9 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000124 221.0
SHD2_k127_6411985_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1120.0
SHD2_k127_6411985_1 Haem-binding uptake, Tiki superfamily, ChaN - - - 2.965e-206 676.0
SHD2_k127_6411985_10 thiamine diphosphate biosynthetic process K03154 - - 0.0000000000009551 72.0
SHD2_k127_6411985_11 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000008382 65.0
SHD2_k127_6411985_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 585.0
SHD2_k127_6411985_3 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 443.0
SHD2_k127_6411985_4 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000007599 221.0
SHD2_k127_6411985_5 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000000000000002425 206.0
SHD2_k127_6411985_6 Adenylate kinase - - - 0.0000000000000000000000000000000000000000000000003281 183.0
SHD2_k127_6411985_7 GAF domain - - - 0.000000000000000000000000000000000000000000000109 183.0
SHD2_k127_6411985_8 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000412 101.0
SHD2_k127_6426089_0 myo-inosose-2 dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 307.0
SHD2_k127_6426089_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 310.0
SHD2_k127_6426089_2 HD domain - - - 0.000000000000000000000000000000000000000000000000000000031 206.0
SHD2_k127_6426089_3 PFAM CBS domain - - - 0.0000000000000000000000000000007063 130.0
SHD2_k127_6426089_4 Putative regulatory protein - - - 0.0000000000000000000005189 98.0
SHD2_k127_6426089_5 COG0526, thiol-disulfide isomerase and thioredoxins K21636 - 1.1.98.6 0.000000000000009766 79.0
SHD2_k127_6432667_0 proline betaine transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 536.0
SHD2_k127_6432667_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 483.0
SHD2_k127_6432667_2 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001723 258.0
SHD2_k127_6432667_3 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000000000000000000000000004704 180.0
SHD2_k127_6432667_4 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000008699 154.0
SHD2_k127_6432667_5 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000002595 113.0
SHD2_k127_6432667_6 EamA-like transporter family - - - 0.000000000000000000005608 104.0
SHD2_k127_6445711_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 5.426e-197 619.0
SHD2_k127_6445711_1 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 483.0
SHD2_k127_6445711_2 Spermidine synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006964 279.0
SHD2_k127_6445711_3 - - - - 0.0000000000002277 73.0
SHD2_k127_6445711_4 NAD(P)-binding Rossmann-like domain - - - 0.00000009054 53.0
SHD2_k127_64517_0 UDP-glucose 4-epimerase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 469.0
SHD2_k127_64517_1 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001094 286.0
SHD2_k127_64517_2 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000003515 121.0
SHD2_k127_64517_3 Radical SAM superfamily - - - 0.000000000000000000002513 100.0
SHD2_k127_64517_4 Methyltransferase domain - - - 0.00001814 56.0
SHD2_k127_6472919_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.754e-283 882.0
SHD2_k127_6472919_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000981 183.0
SHD2_k127_6481929_0 PFAM LemA family protein K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 293.0
SHD2_k127_6481929_1 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000133 285.0
SHD2_k127_6481929_10 positive regulation of MDA-5 signaling pathway K21440 - - 0.0004156 47.0
SHD2_k127_6481929_2 LysM domain K01449,K19223 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000004407 256.0
SHD2_k127_6481929_3 DegT/DnrJ/EryC1/StrS aminotransferase family K14260 - 2.6.1.2,2.6.1.66 0.000000000000000000000000000000000000000000000000000000000000009696 230.0
SHD2_k127_6481929_4 Pfam:TPM K08988 - - 0.000000000000000000000000000000000000000000000000000000000001732 222.0
SHD2_k127_6481929_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000002309 124.0
SHD2_k127_6481929_6 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000002577 126.0
SHD2_k127_6481929_7 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.000000000000000000000000000009373 122.0
SHD2_k127_6481929_8 CHASE K02488,K21009 - 2.7.7.65 0.000000000000000000000000001112 123.0
SHD2_k127_6481929_9 acr, cog1993 K09137 - - 0.0000000000000000000001323 100.0
SHD2_k127_6482689_0 Belongs to the peptidase M16 family K07263 - - 5e-324 1015.0
SHD2_k127_6482689_1 UvrD-like helicase C-terminal domain K03656,K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 609.0
SHD2_k127_6482689_10 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.000000000000000000000000000000000000000000000000000000000000007481 224.0
SHD2_k127_6482689_11 heat shock protein binding - - - 0.0000000000000000000000000000000000000000000000000000000000007673 222.0
SHD2_k127_6482689_12 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000000000000000000007569 186.0
SHD2_k127_6482689_13 organic phosphonate transport K02044 - - 0.00000000000000000000000000000000000000704 158.0
SHD2_k127_6482689_14 SWI complex, BAF60b domains - - - 0.0000000000000000000000000000000004332 135.0
SHD2_k127_6482689_15 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.000000000000000000000000000077 120.0
SHD2_k127_6482689_16 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000732 81.0
SHD2_k127_6482689_17 - - - - 0.00000000008027 65.0
SHD2_k127_6482689_18 - K07092 - - 0.00008467 50.0
SHD2_k127_6482689_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 480.0
SHD2_k127_6482689_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 418.0
SHD2_k127_6482689_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 388.0
SHD2_k127_6482689_5 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 340.0
SHD2_k127_6482689_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 333.0
SHD2_k127_6482689_7 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 319.0
SHD2_k127_6482689_8 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002873 265.0
SHD2_k127_6482689_9 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000001775 227.0
SHD2_k127_6516901_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1023.0
SHD2_k127_6516901_1 Major Facilitator Superfamily K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 466.0
SHD2_k127_6516901_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008925 418.0
SHD2_k127_6516901_3 phosphatase activity K20881 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008387 278.0
SHD2_k127_6516901_4 denitrification pathway K02569,K15876 - - 0.00000000000000000000000000000000000000000000000003354 192.0
SHD2_k127_6516901_6 Cysteine-rich small domain K07162 - - 0.000000000000000009357 86.0
SHD2_k127_6516901_7 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000002615 82.0
SHD2_k127_6523205_0 Virulence factor BrkB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 304.0
SHD2_k127_6523205_1 retrograde transport, endosome to Golgi K07095 - - 0.0000000000000000000000000000000000000000000000000006015 188.0
SHD2_k127_6523205_2 Peptidase MA superfamily - - - 0.00000000000000000000000000000000000000000000000008327 193.0
SHD2_k127_6523205_3 Transcriptional regulator, LysR - - - 0.00000000002975 68.0
SHD2_k127_6523205_4 Protein of unknown function (DUF1059) - - - 0.000000006154 58.0
SHD2_k127_6523874_0 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 580.0
SHD2_k127_6523874_1 glucose sorbosone K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 441.0
SHD2_k127_6523874_2 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 370.0
SHD2_k127_6523874_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 328.0
SHD2_k127_6523874_4 Ecdysteroid kinase - - - 0.0000000000000000000000000000000000000000000000000000001279 207.0
SHD2_k127_6523874_5 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.000000000000000000000000000000001014 136.0
SHD2_k127_6523874_6 Protein of unknown function (DUF1264) - - - 0.000000000000002845 83.0
SHD2_k127_6529302_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 406.0
SHD2_k127_6529302_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 320.0
SHD2_k127_6529302_2 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000002781 230.0
SHD2_k127_6529302_3 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000002308 176.0
SHD2_k127_6529302_4 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000005068 133.0
SHD2_k127_6529302_5 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - 0.000000000000000000004043 94.0
SHD2_k127_6568571_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 4.455e-312 972.0
SHD2_k127_6568571_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.149e-287 903.0
SHD2_k127_6568571_10 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 397.0
SHD2_k127_6568571_11 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 389.0
SHD2_k127_6568571_12 Transglycosylase SLT domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 376.0
SHD2_k127_6568571_13 Signal transduction histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 358.0
SHD2_k127_6568571_14 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 343.0
SHD2_k127_6568571_15 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 350.0
SHD2_k127_6568571_16 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 325.0
SHD2_k127_6568571_17 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 292.0
SHD2_k127_6568571_18 Transcriptional regulatory protein, C terminal K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 289.0
SHD2_k127_6568571_19 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000205 297.0
SHD2_k127_6568571_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 1.154e-201 635.0
SHD2_k127_6568571_20 Type II and III secretion system protein K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000808 290.0
SHD2_k127_6568571_21 phosphoesterase RecJ domain protein K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000321 248.0
SHD2_k127_6568571_22 metal ion binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000006081 239.0
SHD2_k127_6568571_23 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000002368 232.0
SHD2_k127_6568571_24 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000000000495 211.0
SHD2_k127_6568571_25 Protein of unknown function DUF47 K02039,K07220 - - 0.00000000000000000000000000000000000000000000000009549 184.0
SHD2_k127_6568571_26 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000000000109 179.0
SHD2_k127_6568571_27 Archaea-specific editing domain of threonyl-tRNA synthetase - - - 0.0000000000000000000000000000000000000000000001397 173.0
SHD2_k127_6568571_28 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000001493 158.0
SHD2_k127_6568571_29 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000006899 137.0
SHD2_k127_6568571_3 pathogenesis K13669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004943 635.0
SHD2_k127_6568571_30 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000002832 108.0
SHD2_k127_6568571_31 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000001014 89.0
SHD2_k127_6568571_32 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000000004304 91.0
SHD2_k127_6568571_33 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000003969 86.0
SHD2_k127_6568571_34 Pilus assembly protein, PilP K02665 - - 0.00000000002045 71.0
SHD2_k127_6568571_35 CAAX protease self-immunity K07052 - - 0.0000000003456 68.0
SHD2_k127_6568571_36 Pilus assembly protein, PilO K02664 - - 0.000000005518 64.0
SHD2_k127_6568571_37 PFAM Fimbrial assembly K02663 - - 0.00000003838 61.0
SHD2_k127_6568571_4 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 596.0
SHD2_k127_6568571_5 Belongs to the PstS family K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 479.0
SHD2_k127_6568571_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 441.0
SHD2_k127_6568571_7 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 427.0
SHD2_k127_6568571_8 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 400.0
SHD2_k127_6568571_9 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003816 394.0
SHD2_k127_6587398_0 Sigma-54 interaction domain K02481,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 444.0
SHD2_k127_6587398_1 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000001841 245.0
SHD2_k127_6587398_2 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000001549 127.0
SHD2_k127_6593401_0 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 557.0
SHD2_k127_6593401_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009111 501.0
SHD2_k127_6593401_2 HELICc2 K03722 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007782 363.0
SHD2_k127_6593401_3 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 286.0
SHD2_k127_6593401_4 GDP-mannose mannosyl hydrolase activity - - - 0.00000000000000000002306 93.0
SHD2_k127_6597161_0 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 302.0
SHD2_k127_6597161_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 300.0
SHD2_k127_6597161_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000005499 240.0
SHD2_k127_6597161_3 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000000000000000004413 185.0
SHD2_k127_66094_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1302.0
SHD2_k127_66094_1 Molybdopterin oxidoreductase Fe4S4 domain K00336 - 1.6.5.3 0.0 1215.0
SHD2_k127_66094_10 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 610.0
SHD2_k127_66094_11 SEFIR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 550.0
SHD2_k127_66094_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 499.0
SHD2_k127_66094_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 490.0
SHD2_k127_66094_14 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000791 494.0
SHD2_k127_66094_15 UDP binding domain K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 466.0
SHD2_k127_66094_16 AAA ATPase K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008112 450.0
SHD2_k127_66094_17 Sulphur transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 434.0
SHD2_k127_66094_18 GDP-mannose 4,6 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 425.0
SHD2_k127_66094_19 PFAM Radical SAM K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008758 415.0
SHD2_k127_66094_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K13378 - 1.6.5.3 6.886e-307 947.0
SHD2_k127_66094_20 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 398.0
SHD2_k127_66094_21 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 402.0
SHD2_k127_66094_22 MatE K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 394.0
SHD2_k127_66094_23 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 385.0
SHD2_k127_66094_24 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 381.0
SHD2_k127_66094_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 342.0
SHD2_k127_66094_26 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 342.0
SHD2_k127_66094_27 PFAM Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 349.0
SHD2_k127_66094_29 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 339.0
SHD2_k127_66094_3 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 3.181e-276 868.0
SHD2_k127_66094_30 Cytochrome b/b6/petB K00412,K03888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 341.0
SHD2_k127_66094_31 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 328.0
SHD2_k127_66094_32 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 333.0
SHD2_k127_66094_33 SagB-type dehydrogenase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 319.0
SHD2_k127_66094_34 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 312.0
SHD2_k127_66094_35 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 318.0
SHD2_k127_66094_36 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004719 313.0
SHD2_k127_66094_37 rRNA (uridine-N3-)-methyltransferase activity K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 293.0
SHD2_k127_66094_38 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 292.0
SHD2_k127_66094_39 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001063 281.0
SHD2_k127_66094_4 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 6.471e-237 754.0
SHD2_k127_66094_40 COGs COG0463 Glycosyltransferase involved in cell wall biogenesis K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001614 280.0
SHD2_k127_66094_41 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002911 234.0
SHD2_k127_66094_42 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000003791 224.0
SHD2_k127_66094_43 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000001761 214.0
SHD2_k127_66094_44 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000002717 188.0
SHD2_k127_66094_45 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000003467 176.0
SHD2_k127_66094_46 PFAM PHP domain - - - 0.000000000000000000000000000000000000000000001693 171.0
SHD2_k127_66094_47 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000000000000229 164.0
SHD2_k127_66094_48 Universal stress protein family - - - 0.0000000000000000000000000000000000000000001356 164.0
SHD2_k127_66094_49 Universal stress protein family - - - 0.00000000000000000000000000000000000000001695 157.0
SHD2_k127_66094_5 cell redox homeostasis - - - 2.238e-220 692.0
SHD2_k127_66094_50 PFAM Carboxymuconolactone decarboxylase - - - 0.00000000000000000000000000000000001131 138.0
SHD2_k127_66094_51 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000002202 138.0
SHD2_k127_66094_52 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000000000000006772 141.0
SHD2_k127_66094_53 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000225 125.0
SHD2_k127_66094_54 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000003712 117.0
SHD2_k127_66094_55 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000006086 103.0
SHD2_k127_66094_56 - - - - 0.000000000000000000001109 98.0
SHD2_k127_66094_57 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000009227 93.0
SHD2_k127_66094_58 FecR protein - - - 0.00000000000000000519 93.0
SHD2_k127_66094_59 - - - - 0.0000000000006812 72.0
SHD2_k127_66094_6 SMART Elongator protein 3 MiaB NifB - - - 3.989e-216 680.0
SHD2_k127_66094_60 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.000000000002005 80.0
SHD2_k127_66094_61 Universal stress protein family - - - 0.000000000002311 73.0
SHD2_k127_66094_62 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.000000000008716 68.0
SHD2_k127_66094_63 Tetratricopeptide repeat - - - 0.000000009302 68.0
SHD2_k127_66094_65 - - - - 0.000001831 55.0
SHD2_k127_66094_66 PFAM DsrE DsrF-like family - - - 0.000002597 53.0
SHD2_k127_66094_67 PKD domain - - - 0.000361 53.0
SHD2_k127_66094_7 Endoribonuclease that initiates mRNA decay K18682 - - 1.516e-208 664.0
SHD2_k127_66094_8 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 3.801e-208 654.0
SHD2_k127_66094_9 Proton-conducting membrane transporter K00342 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 6.66e-199 635.0
SHD2_k127_6680282_0 GAF domain - - - 1.057e-201 679.0
SHD2_k127_6680282_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 535.0
SHD2_k127_6680282_10 SpoVT / AbrB like domain - - - 0.00000000000000000005697 91.0
SHD2_k127_6680282_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 427.0
SHD2_k127_6680282_3 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 329.0
SHD2_k127_6680282_4 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 302.0
SHD2_k127_6680282_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000002522 250.0
SHD2_k127_6680282_6 protocatechuate 3,4-dioxygenase activity K03381 - 1.13.11.1 0.0000000000000000000000000000000000000000000000007712 179.0
SHD2_k127_6680282_7 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000001516 170.0
SHD2_k127_6680282_8 radical SAM domain protein - - - 0.00000000000000000000000000000000897 139.0
SHD2_k127_6680282_9 nucleic-acid-binding protein contains PIN domain - - - 0.00000000000000000000000000000002614 130.0
SHD2_k127_6693593_0 Actin K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 519.0
SHD2_k127_6693593_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 505.0
SHD2_k127_6693593_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 426.0
SHD2_k127_6693593_3 shape-determining protein MreC K03570 - - 0.00000000000000000000000000000000000000000000004426 179.0
SHD2_k127_6730811_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 1.494e-199 634.0
SHD2_k127_6730811_1 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 567.0
SHD2_k127_6730811_11 - - - - 0.000000006668 57.0
SHD2_k127_6730811_2 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 451.0
SHD2_k127_6730811_3 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 395.0
SHD2_k127_6730811_4 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 373.0
SHD2_k127_6730811_5 ABC-type sugar transport system, permease component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 355.0
SHD2_k127_6730811_6 Binding-protein-dependent transport system inner membrane component K02025,K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 354.0
SHD2_k127_6730811_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 289.0
SHD2_k127_6730811_8 Calcineurin-like phosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000192 227.0
SHD2_k127_6730811_9 PFAM Transglycosylase-associated protein - - - 0.000000000000002274 79.0
SHD2_k127_6736151_0 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 594.0
SHD2_k127_6736151_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 308.0
SHD2_k127_6736151_2 PFAM PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002529 273.0
SHD2_k127_6736151_3 lactate metabolic process K11473,K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000001722 245.0
SHD2_k127_6736151_4 - - - - 0.0000000000000000000000000000000000579 138.0
SHD2_k127_6736151_5 - - - - 0.00000000000000000004097 91.0
SHD2_k127_6736151_6 addiction module toxin, RelE StbE family K06218 - - 0.00002197 50.0
SHD2_k127_6772443_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 1.925e-269 843.0
SHD2_k127_6772443_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 378.0
SHD2_k127_6772443_2 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005524 273.0
SHD2_k127_6772443_3 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000005139 57.0
SHD2_k127_6837249_0 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 327.0
SHD2_k127_6837249_1 metalloendopeptidase activity K03799 - - 0.000000000000000000000002928 113.0
SHD2_k127_6837249_2 denitrification pathway - - - 0.000005071 50.0
SHD2_k127_6900125_0 Ammonium Transporter Family K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 587.0
SHD2_k127_6900125_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000002121 80.0
SHD2_k127_6916811_0 HMGL-like K01666 - 4.1.3.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 391.0
SHD2_k127_6916811_1 Response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 318.0
SHD2_k127_6916811_2 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000000000000001112 161.0
SHD2_k127_6916811_3 Domain of unknown function DUF302 - - - 0.0000000000000003308 89.0
SHD2_k127_69935_0 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 369.0
SHD2_k127_69935_1 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 283.0
SHD2_k127_69935_2 Phospholipase, patatin family K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001284 278.0
SHD2_k127_69935_3 Protein of unknown function (DUF3617) - - - 0.000000000000000000000000000000001644 132.0
SHD2_k127_69935_4 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000009713 76.0
SHD2_k127_6997641_0 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007078 402.0
SHD2_k127_6997641_1 Chromate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 381.0
SHD2_k127_6997641_2 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002119 265.0
SHD2_k127_7056943_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 336.0
SHD2_k127_7056943_1 Glycine zipper 2TM domain - - - 0.0000000000000000000000000000000000000000292 156.0
SHD2_k127_7056943_2 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.000000000000000000000000000008787 126.0
SHD2_k127_7056943_3 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.00000000000000000000000001474 113.0
SHD2_k127_7056943_4 PLD-like domain K06131 - - 0.0000000000000000000000004738 110.0
SHD2_k127_7056943_5 - - - - 0.0000000000000006559 81.0
SHD2_k127_7056943_6 PFAM Rubrerythrin - - - 0.000000000002635 73.0
SHD2_k127_7101863_0 ABC transporter K06158 - - 1.541e-228 721.0
SHD2_k127_7101863_1 PilZ domain - - - 0.0000000000000000000005736 105.0
SHD2_k127_7101863_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000002114 52.0
SHD2_k127_7151656_0 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 355.0
SHD2_k127_7151656_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K14080 - 2.1.1.246,4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 315.0
SHD2_k127_7151656_2 PFAM Carboxymuconolactone decarboxylase - - - 0.0000000000000000000000000000000000000006709 154.0
SHD2_k127_7151656_3 OsmC-like protein - - - 0.00000000000000003342 88.0
SHD2_k127_7151656_4 PBS lyase HEAT-like repeat - - - 0.000000000001145 74.0
SHD2_k127_7151656_5 Protein of unknown function (DUF2934) - - - 0.000002799 53.0
SHD2_k127_726498_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 386.0
SHD2_k127_726498_1 Yip1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001153 244.0
SHD2_k127_726498_2 ATPase (AAA superfamily) K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000001016 243.0
SHD2_k127_726498_3 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000002867 225.0
SHD2_k127_726498_4 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000008488 182.0
SHD2_k127_726498_5 PFAM aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000591 171.0
SHD2_k127_726498_6 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000001977 147.0
SHD2_k127_7416285_0 GTP-binding protein TypA K06207 - - 2.372e-264 826.0
SHD2_k127_7416285_1 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008952 547.0
SHD2_k127_7416285_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000002648 259.0
SHD2_k127_7416285_11 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000003385 240.0
SHD2_k127_7416285_12 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000003279 218.0
SHD2_k127_7416285_13 Signal transduction histidine kinase, nitrogen specific K07708 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 0.0000000000000000000000000000000000000000000000000246 192.0
SHD2_k127_7416285_14 C4-type zinc ribbon domain K07164 - - 0.000000000000000000000000000000000000000000436 167.0
SHD2_k127_7416285_15 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000001428 169.0
SHD2_k127_7416285_16 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000004017 153.0
SHD2_k127_7416285_17 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000005429 93.0
SHD2_k127_7416285_19 - - - - 0.000359 49.0
SHD2_k127_7416285_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 506.0
SHD2_k127_7416285_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 435.0
SHD2_k127_7416285_4 response regulator K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 411.0
SHD2_k127_7416285_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 412.0
SHD2_k127_7416285_6 Transcriptional regulator K11921,K19338 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007108 378.0
SHD2_k127_7416285_7 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 359.0
SHD2_k127_7416285_8 Thiamine biosynthesis protein (ThiI) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 309.0
SHD2_k127_7418462_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.688e-271 842.0
SHD2_k127_7418462_1 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335,K00355,K18331 - 1.12.1.3,1.6.5.2,1.6.5.3 5.077e-262 820.0
SHD2_k127_7418462_10 PHP-associated K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000007789 224.0
SHD2_k127_7418462_11 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000000000001608 184.0
SHD2_k127_7418462_12 SMART ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000008521 180.0
SHD2_k127_7418462_13 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K18330 - 1.12.1.3 0.000000000000000000000000000000000000000000000001869 185.0
SHD2_k127_7418462_14 zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000008064 181.0
SHD2_k127_7418462_15 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000000000000000000000000004356 158.0
SHD2_k127_7418462_16 Ferredoxin K17992 - 1.12.1.3 0.0000000000000000000000000000000000001492 145.0
SHD2_k127_7418462_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000001352 146.0
SHD2_k127_7418462_18 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.0000000000000000000000000000000002802 134.0
SHD2_k127_7418462_19 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000508 134.0
SHD2_k127_7418462_2 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 579.0
SHD2_k127_7418462_20 SCO1 SenC K07152 - - 0.00000000000000000000000000000007282 128.0
SHD2_k127_7418462_21 DRTGG domain - - - 0.000000000000000000000000000003221 124.0
SHD2_k127_7418462_22 phosphorelay signal transduction system K02437 - - 0.00000000000000000000000001361 119.0
SHD2_k127_7418462_23 DRTGG domain protein - - - 0.00000000000000000000000001631 112.0
SHD2_k127_7418462_24 Universal stress protein family - - - 0.00000000000001462 85.0
SHD2_k127_7418462_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000002417 53.0
SHD2_k127_7418462_26 SdpI/YhfL protein family - - - 0.00001098 48.0
SHD2_k127_7418462_3 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 548.0
SHD2_k127_7418462_4 response regulator K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 495.0
SHD2_k127_7418462_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 469.0
SHD2_k127_7418462_6 histidine kinase, HAMP K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 351.0
SHD2_k127_7418462_7 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 335.0
SHD2_k127_7418462_8 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 322.0
SHD2_k127_7418462_9 (Rhomboid) family K07059 - - 0.00000000000000000000000000000000000000000000000000000000000000000003583 238.0
SHD2_k127_7428275_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 2.592e-295 914.0
SHD2_k127_7428275_1 COG1233 Phytoene dehydrogenase and related proteins K09516,K09835 - 1.3.99.23,5.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 494.0
SHD2_k127_7428275_2 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 387.0
SHD2_k127_7428275_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 310.0
SHD2_k127_7428275_4 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000009538 259.0
SHD2_k127_7428275_5 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006401 261.0
SHD2_k127_7428275_6 Transposase (IS116 IS110 IS902 family) K07486 - - 0.0000000000000000000000000000000000000000000000000000000007395 204.0
SHD2_k127_7428275_7 Transposase IS116/IS110/IS902 family - - - 0.000000000000000000000000000000000000000000001325 177.0
SHD2_k127_7428275_8 NosL - - - 0.000000000000000000000000000000000000001336 154.0
SHD2_k127_7428275_9 - - - - 0.00000000000001092 77.0
SHD2_k127_7437581_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 607.0
SHD2_k127_7437581_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000005168 198.0
SHD2_k127_7437581_2 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000002037 121.0
SHD2_k127_7437581_3 - - - - 0.00000000000000000003596 101.0
SHD2_k127_7441282_0 COG3901 Regulator of nitric oxide reductase transcription K19339,K19343 - - 1.191e-200 637.0
SHD2_k127_7441282_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 352.0
SHD2_k127_7441282_2 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005679 245.0
SHD2_k127_7441666_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 0.0 1093.0
SHD2_k127_7441666_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 493.0
SHD2_k127_7441666_10 nucleic acid-binding protein contains PIN domain - - - 0.0009765 48.0
SHD2_k127_7441666_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000001314 222.0
SHD2_k127_7441666_3 Peptidase S24-like K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000002973 209.0
SHD2_k127_7441666_4 pfam nudix - - - 0.000000000000000000000000000000000000000000000000000000003258 203.0
SHD2_k127_7441666_5 AMP binding K09118,K13693 - 2.4.1.266 0.0000000000000000000000001322 117.0
SHD2_k127_7441666_6 Domain of unknown function (DUF4412) - - - 0.0000000000000000000001871 106.0
SHD2_k127_7441666_7 protein conserved in bacteria - - - 0.000000000000000002002 89.0
SHD2_k127_7441666_8 phosphorelay signal transduction system - - - 0.00005936 47.0
SHD2_k127_7441666_9 toxin-antitoxin pair type II binding - - - 0.00009889 48.0
SHD2_k127_7443142_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 423.0
SHD2_k127_7443142_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 358.0
SHD2_k127_7443142_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 319.0
SHD2_k127_7443142_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004676 311.0
SHD2_k127_7443142_4 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 296.0
SHD2_k127_7443142_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000215 224.0
SHD2_k127_7443142_6 OsmC-like protein K07397 - - 0.00000000000000000000002478 106.0
SHD2_k127_7449883_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 6.732e-263 829.0
SHD2_k127_7449883_1 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 2.114e-243 774.0
SHD2_k127_7449883_10 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 339.0
SHD2_k127_7449883_11 DNA recombination-mediator protein A K03168,K04096 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000789 320.0
SHD2_k127_7449883_12 TIGRFAM riboflavin biosynthesis protein RibF K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 292.0
SHD2_k127_7449883_13 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 288.0
SHD2_k127_7449883_14 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 286.0
SHD2_k127_7449883_15 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001039 266.0
SHD2_k127_7449883_16 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001344 258.0
SHD2_k127_7449883_17 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008805 244.0
SHD2_k127_7449883_18 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002958 244.0
SHD2_k127_7449883_19 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008074 243.0
SHD2_k127_7449883_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 3.278e-196 617.0
SHD2_k127_7449883_20 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000005158 234.0
SHD2_k127_7449883_21 HNH nucleases - - - 0.00000000000000000000000000000000000000000000001171 174.0
SHD2_k127_7449883_22 mRNA catabolic process - - - 0.00000000000000000000000000000000000000000000008103 178.0
SHD2_k127_7449883_23 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000002175 152.0
SHD2_k127_7449883_24 TIGRFAM diguanylate cyclase - - - 0.0000000000000000000000000000000000002188 160.0
SHD2_k127_7449883_25 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000002225 139.0
SHD2_k127_7449883_26 Transcriptional regulator, MerR family - - - 0.0000000000000000000000000000000001958 137.0
SHD2_k127_7449883_27 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000000000000000009998 126.0
SHD2_k127_7449883_28 isomerase activity K01821 - 5.3.2.6 0.0000000000000000000000001572 109.0
SHD2_k127_7449883_29 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000003009 107.0
SHD2_k127_7449883_3 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 603.0
SHD2_k127_7449883_30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000002821 97.0
SHD2_k127_7449883_31 Diguanylate cyclase - - - 0.000000000000000000556 102.0
SHD2_k127_7449883_32 GAF domain - - - 0.0000000000000001103 94.0
SHD2_k127_7449883_34 Seven times multi-haem cytochrome CxxCH - - - 0.00000000000002292 72.0
SHD2_k127_7449883_36 Belongs to the peptidase M48B family - - - 0.00000001974 58.0
SHD2_k127_7449883_37 Histidine kinase K02660,K11525 - - 0.0002142 54.0
SHD2_k127_7449883_39 His Kinase A (phosphoacceptor) domain - - - 0.0008243 50.0
SHD2_k127_7449883_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006916 570.0
SHD2_k127_7449883_5 PFAM binding-protein-dependent transport systems inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008193 424.0
SHD2_k127_7449883_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003944 414.0
SHD2_k127_7449883_7 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 388.0
SHD2_k127_7449883_8 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006998 375.0
SHD2_k127_7449883_9 Mur ligase, middle domain protein K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 347.0
SHD2_k127_7457644_0 Sigma-54 interaction domain - - - 9.098e-212 666.0
SHD2_k127_7457644_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 386.0
SHD2_k127_7457644_2 Histidine kinase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 333.0
SHD2_k127_7457644_3 methyl-accepting chemotaxis protein K03406 - - 0.000000000889 63.0
SHD2_k127_7465323_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 451.0
SHD2_k127_7465323_1 PFAM Fatty acid hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 325.0
SHD2_k127_7465323_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 314.0
SHD2_k127_7465323_3 Belongs to the peptidase M48B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000186 246.0
SHD2_k127_7465323_4 PFAM Glycosyl transferase family 2 K09931 - - 0.00000000000000000000000000000000000000000000000000003981 195.0
SHD2_k127_7465323_5 Uncharacterized protein conserved in bacteria (DUF2064) K09931,K20742 - 3.4.14.13 0.00000000000000000000000000000000000000001461 163.0
SHD2_k127_7465323_6 Acetyltransferase (GNAT) domain K00663 - 2.3.1.82 0.0006926 49.0
SHD2_k127_7478776_0 TIGRFAM hopanoid biosynthesis associated glycosyl transferase protein HpnI K00720 - 2.4.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000134 282.0
SHD2_k127_7478776_1 Carotenoid biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002066 262.0
SHD2_k127_7478776_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000004047 73.0
SHD2_k127_7478776_3 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively K01243 - 3.2.2.9 0.00000000000941 74.0
SHD2_k127_7478776_4 Histidine kinase-like ATPases - - - 0.00000000005817 74.0
SHD2_k127_7478776_5 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain K07720 - - 0.00003671 55.0
SHD2_k127_7478776_6 OmpA family K02557 - - 0.0004688 51.0
SHD2_k127_7484505_0 Belongs to the glycosyl hydrolase 57 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008616 396.0
SHD2_k127_7484505_1 COG0564 Pseudouridylate synthases, 23S RNA-specific K06177 - 5.4.99.28,5.4.99.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006201 275.0
SHD2_k127_7484505_2 PFAM Smr protein MutS2 - - - 0.0000000000000000000000000006174 118.0
SHD2_k127_7484505_3 signal transduction histidine kinase - - - 0.00000000000000000000001295 113.0
SHD2_k127_7484505_4 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000002275 95.0
SHD2_k127_7486450_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1077.0
SHD2_k127_7486450_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 2.255e-198 620.0
SHD2_k127_7490888_0 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 2.608e-244 770.0
SHD2_k127_7490888_1 domain, Protein K01176,K03332 - 3.2.1.1,3.2.1.80 3.74e-221 708.0
SHD2_k127_7490888_2 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009219 416.0
SHD2_k127_7490888_3 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 374.0
SHD2_k127_7490888_4 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009744 369.0
SHD2_k127_7490888_5 Formyl transferase - - - 0.000000000000000000000000000000002324 140.0
SHD2_k127_7490888_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000005997 111.0
SHD2_k127_7490888_7 Tetratricopeptide repeat - - - 0.0000000000003222 79.0
SHD2_k127_7490888_8 Polysaccharide deacetylase - - - 0.000000000002642 78.0
SHD2_k127_7512488_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007758 569.0
SHD2_k127_7512488_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 533.0
SHD2_k127_7512488_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007032 484.0
SHD2_k127_7512488_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007229 419.0
SHD2_k127_7512488_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003169 252.0
SHD2_k127_7512488_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000648 201.0
SHD2_k127_7512488_6 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000001387 154.0
SHD2_k127_7512488_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000001442 147.0
SHD2_k127_7533343_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 1.166e-272 861.0
SHD2_k127_7533343_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 555.0
SHD2_k127_7533343_10 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007818 334.0
SHD2_k127_7533343_11 CHASE K02488,K21009 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000007918 225.0
SHD2_k127_7533343_12 aminopeptidase N - - - 0.0000000000000000000000000000000000000000000000000000001101 208.0
SHD2_k127_7533343_14 - - - - 0.000000000000000000000000000000000000000000000001893 179.0
SHD2_k127_7533343_16 Glycine-zipper domain - - - 0.000000000000000000000000000000000000000004081 160.0
SHD2_k127_7533343_17 Membrane - - - 0.00000000000000000000001066 109.0
SHD2_k127_7533343_18 - - - - 0.00000000000000002447 89.0
SHD2_k127_7533343_19 Membrane - - - 0.0000000000000006002 87.0
SHD2_k127_7533343_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 535.0
SHD2_k127_7533343_20 Protein of unknown function (DUF2892) - - - 0.000000000001126 72.0
SHD2_k127_7533343_21 ABC transporter K06158 - - 0.00000002141 57.0
SHD2_k127_7533343_22 - - - - 0.0000001166 54.0
SHD2_k127_7533343_23 Transposase IS200 like - - - 0.0004132 44.0
SHD2_k127_7533343_3 HlyD family secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 497.0
SHD2_k127_7533343_4 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 479.0
SHD2_k127_7533343_5 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005834 444.0
SHD2_k127_7533343_6 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 431.0
SHD2_k127_7533343_7 PFAM MscS Mechanosensitive ion channel K03442 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 382.0
SHD2_k127_7533343_8 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 357.0
SHD2_k127_7533343_9 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 339.0
SHD2_k127_7575188_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 399.0
SHD2_k127_7575188_1 sugar transferase K00996 - 2.7.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 391.0
SHD2_k127_7575188_2 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001069 280.0
SHD2_k127_7575188_3 transferase activity, transferring glycosyl groups K00745,K12988,K18704 - 2.4.1.166,2.7.8.14,2.7.8.47 0.00000000000000000000000000000000000000000000000000000000000000000004377 237.0
SHD2_k127_7575188_4 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000000000000000000000000000000000000000000002631 235.0
SHD2_k127_7575188_5 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000004429 227.0
SHD2_k127_7575188_7 - - - - 0.000000000003836 68.0
SHD2_k127_7578303_0 ABC transporter K02021,K06147,K11085 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 501.0
SHD2_k127_7578303_1 transferase activity, transferring glycosyl groups K13500 - 2.4.1.175,2.4.1.226 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 296.0
SHD2_k127_7578303_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000009998 126.0
SHD2_k127_7578303_3 O-Antigen ligase K02847 - - 0.000000000000331 81.0
SHD2_k127_7578303_4 CYTH K05873 - 4.6.1.1 0.000000000002791 74.0
SHD2_k127_75836_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 467.0
SHD2_k127_75836_1 DsrE/DsrF-like family K06039 - - 0.000000000000000000000000000000000000002431 148.0
SHD2_k127_75836_2 DNA-binding transcription factor activity K03655,K03892,K21903 - 3.6.4.12 0.0000000000000000003733 91.0
SHD2_k127_75836_3 MMPL family K07003 - - 0.000000000000001066 78.0
SHD2_k127_75836_4 Receptor - - - 0.0000000004453 61.0
SHD2_k127_75836_5 sulfur relay protein TusB DsrH K07237 - - 0.0000002969 55.0
SHD2_k127_75836_6 PFAM DsrE family protein K07235 - - 0.0001619 49.0
SHD2_k127_75836_7 MMPL family K07003 - - 0.0005693 43.0
SHD2_k127_75836_8 DsrE/DsrF-like family K07235 - - 0.0007284 46.0
SHD2_k127_7587990_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 417.0
SHD2_k127_7587990_1 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008455 318.0
SHD2_k127_7587990_2 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002852 285.0
SHD2_k127_7587990_3 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000004483 235.0
SHD2_k127_7587990_4 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000008107 147.0
SHD2_k127_7587990_5 denitrification pathway - - - 0.00000000000000000000000000004954 123.0
SHD2_k127_7587990_6 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000009855 57.0
SHD2_k127_7587990_7 histidine kinase-, DNA gyrase B - - - 0.0002469 51.0
SHD2_k127_7655542_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 517.0
SHD2_k127_7655542_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008885 431.0
SHD2_k127_7655542_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000006168 241.0
SHD2_k127_7655542_3 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000001251 217.0
SHD2_k127_7655542_4 metal-dependent phosphohydrolase HD region - - - 0.000000000000000000000000000000000000000000000000000000002806 216.0
SHD2_k127_7655542_5 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000000000000000000000000001314 154.0
SHD2_k127_7681135_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.329e-211 664.0
SHD2_k127_7681135_1 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 468.0
SHD2_k127_7681135_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 363.0
SHD2_k127_7681135_3 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 287.0
SHD2_k127_7681135_4 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000002138 235.0
SHD2_k127_7681135_5 PFAM amino acid-binding ACT domain protein - - - 0.000000000000000000000000000000000000000000000000000000000007723 209.0
SHD2_k127_7692990_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 595.0
SHD2_k127_7692990_1 Apoptosis-inducing factor, mitochondrion-associated, C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 380.0
SHD2_k127_7692990_2 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000005738 244.0
SHD2_k127_7692990_3 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000002811 231.0
SHD2_k127_7692990_4 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000004546 195.0
SHD2_k127_7692990_5 Dihydroneopterin aldolase - - - 0.0000000000000000000000000000000000000008114 156.0
SHD2_k127_7692990_6 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000002308 151.0
SHD2_k127_7692990_7 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633,K07589 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 1.13.11.81,4.1.2.25,5.1.99.7,5.1.99.8 0.000000000000000000000000000004595 127.0
SHD2_k127_7692990_8 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000006605 99.0
SHD2_k127_7815176_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 301.0
SHD2_k127_7815176_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000124 277.0
SHD2_k127_7815176_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000007427 244.0
SHD2_k127_7815176_3 Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.000000000000000000000000000000000000000000000000001771 203.0
SHD2_k127_7815176_4 response regulator, receiver - - - 0.000000000000000000000000000009223 136.0
SHD2_k127_7828349_0 cell redox homeostasis - - - 1.013e-209 665.0
SHD2_k127_7828349_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 602.0
SHD2_k127_7828349_10 Signal transduction histidine kinase, nitrogen specific, NtrB K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000004806 238.0
SHD2_k127_7828349_11 NapC/NirT cytochrome c family, N-terminal region K15876 - - 0.0000000000000000000000000000000000000000000000000000000000000008623 221.0
SHD2_k127_7828349_12 response regulator - - - 0.0000000000000000000000000000000000009523 147.0
SHD2_k127_7828349_13 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000005742 141.0
SHD2_k127_7828349_14 iron-sulfur cluster assembly - - - 0.000000000000000000000004936 102.0
SHD2_k127_7828349_15 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.00000000000000000000002516 100.0
SHD2_k127_7828349_16 TIGRFAM desulfoferrodoxin FeS4 iron-binding domain K05919 - 1.15.1.2 0.000000003542 58.0
SHD2_k127_7828349_18 PFAM Cobalt transport protein K16785 - - 0.0000607 53.0
SHD2_k127_7828349_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007036 493.0
SHD2_k127_7828349_3 N-Acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 477.0
SHD2_k127_7828349_4 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 437.0
SHD2_k127_7828349_5 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 334.0
SHD2_k127_7828349_6 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 326.0
SHD2_k127_7828349_7 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 290.0
SHD2_k127_7828349_8 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000005039 256.0
SHD2_k127_7828349_9 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005527 249.0
SHD2_k127_7839235_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K07303 - 1.3.99.16 1.337e-210 670.0
SHD2_k127_7839235_1 Mechanosensitive ion channel K03442 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 402.0
SHD2_k127_7839235_2 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 345.0
SHD2_k127_7839235_3 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008256 246.0
SHD2_k127_7839235_4 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000003628 231.0
SHD2_k127_7839235_5 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000000000000000000001887 226.0
SHD2_k127_7839235_6 HD domain K06950 - - 0.00000000000000000000000000000000000000000000000000001516 195.0
SHD2_k127_7839235_7 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000000000006045 181.0
SHD2_k127_7845408_0 Exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007443 284.0
SHD2_k127_7845408_1 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000003241 125.0
SHD2_k127_7845408_2 PFAM phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000005109 87.0
SHD2_k127_7845408_3 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.000000000000002827 76.0
SHD2_k127_7845408_4 Cupin domain - - - 0.00000006976 58.0
SHD2_k127_7846_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 335.0
SHD2_k127_7846_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006158 279.0
SHD2_k127_7846_2 Uncharacterized ACR, COG1678 - - - 0.00000000000000000000000000000000001942 144.0
SHD2_k127_7851969_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005096 404.0
SHD2_k127_7851969_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 352.0
SHD2_k127_7851969_10 PFAM Mammalian cell entry related K02067 - - 0.0000000000000001758 90.0
SHD2_k127_7851969_11 antisigma factor binding K04749,K05946,K06378 - 2.4.1.187 0.0000000000000002405 82.0
SHD2_k127_7851969_12 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00004516 53.0
SHD2_k127_7851969_2 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000909 336.0
SHD2_k127_7851969_3 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 324.0
SHD2_k127_7851969_4 PLD-like domain K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001188 277.0
SHD2_k127_7851969_5 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002331 262.0
SHD2_k127_7851969_6 Protein phosphatase 2C domain K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000002792 252.0
SHD2_k127_7851969_7 Zinc dependent phospholipase C - - - 0.00000000000000000000000000000000000000000000000000002417 198.0
SHD2_k127_7851969_8 SPTR Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000006058 176.0
SHD2_k127_7851969_9 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000000000001017 117.0
SHD2_k127_7851977_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 592.0
SHD2_k127_7851977_1 Mannose-6-phosphate isomerase, type K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008901 575.0
SHD2_k127_7851977_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 426.0
SHD2_k127_7851977_3 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 400.0
SHD2_k127_7853913_0 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 294.0
SHD2_k127_7853913_1 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000001973 153.0
SHD2_k127_7853913_2 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.000000000000000000001409 98.0
SHD2_k127_7898014_0 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 2.529e-194 621.0
SHD2_k127_7898014_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 567.0
SHD2_k127_7898014_10 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 366.0
SHD2_k127_7898014_11 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 326.0
SHD2_k127_7898014_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 317.0
SHD2_k127_7898014_13 Histidine kinase K07641,K07642,K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000004943 275.0
SHD2_k127_7898014_14 phosphatidate phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003612 263.0
SHD2_k127_7898014_15 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000001112 262.0
SHD2_k127_7898014_16 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004214 247.0
SHD2_k127_7898014_17 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000006859 240.0
SHD2_k127_7898014_18 Metallo-beta-lactamase superfamily K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000004818 234.0
SHD2_k127_7898014_19 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000009864 222.0
SHD2_k127_7898014_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 525.0
SHD2_k127_7898014_20 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000002144 177.0
SHD2_k127_7898014_21 MraZ protein, putative antitoxin-like K03925 - - 0.00000000000000000000000000000000000000000000007078 173.0
SHD2_k127_7898014_22 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000008693 152.0
SHD2_k127_7898014_23 RNA-binding protein containing a PIN domain K06962 - - 0.000000000000000000000000000000001181 135.0
SHD2_k127_7898014_24 - - - - 0.00000000000000000000000000007835 119.0
SHD2_k127_7898014_25 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000002829 113.0
SHD2_k127_7898014_26 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000001942 107.0
SHD2_k127_7898014_27 PFAM pyridoxamine 5-phosphate - - - 0.000000000000000807 79.0
SHD2_k127_7898014_28 Belongs to the UPF0235 family K09131 - - 0.00000000000001046 77.0
SHD2_k127_7898014_29 Arylsulfotransferase (ASST) - - - 0.00000000000002944 85.0
SHD2_k127_7898014_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 460.0
SHD2_k127_7898014_30 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000002026 73.0
SHD2_k127_7898014_31 cell division protein FtsQ K03589 - - 0.000000000001211 78.0
SHD2_k127_7898014_34 Protein of unknown function (DUF861) K06995 - - 0.00002443 47.0
SHD2_k127_7898014_36 Evidence 5 No homology to any previously reported sequences - - - 0.0001933 51.0
SHD2_k127_7898014_4 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 458.0
SHD2_k127_7898014_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 419.0
SHD2_k127_7898014_6 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 408.0
SHD2_k127_7898014_7 Cell cycle protein K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 396.0
SHD2_k127_7898014_8 Cell wall formation K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 379.0
SHD2_k127_7898014_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 368.0
SHD2_k127_8036133_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 332.0
SHD2_k127_8036133_1 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000002526 231.0
SHD2_k127_8036133_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000634 155.0
SHD2_k127_8036133_3 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000001314 154.0
SHD2_k127_8036133_4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000001044 135.0
SHD2_k127_8036133_5 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000001493 70.0
SHD2_k127_914197_0 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 1.613e-227 709.0
SHD2_k127_914197_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005878 436.0
SHD2_k127_914197_2 phenylalanine-tRNA ligase activity K01890 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 417.0
SHD2_k127_914197_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 335.0
SHD2_k127_914197_4 histidine kinase, HAMP K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000004528 223.0
SHD2_k127_914197_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000002113 124.0
SHD2_k127_914197_6 mercury ion transmembrane transporter activity K07213 - - 0.0000000000000006051 79.0