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Overview

ID MAG03377
Name SHD2_bin.23
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Eisenbacteria
Class RBG-16-71-46
Order JAGVPR01
Family JAGVPR01
Genus JAGVPR01
Species
Assembly information
Completeness (%) 67.68
Contamination (%) 0.64
GC content (%) 66.0
N50 (bp) 7,333
Genome size (bp) 2,888,460

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2539

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1000129_0 ATPase associated with various cellular K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 441.0
SHD2_k127_1000129_1 Oxygen tolerance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000636 383.0
SHD2_k127_1000129_2 PFAM von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 357.0
SHD2_k127_1000129_3 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 331.0
SHD2_k127_1000129_4 Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 319.0
SHD2_k127_1000129_5 - - - - 0.000000000000000008093 98.0
SHD2_k127_1000984_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1197.0
SHD2_k127_1000984_1 PglZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 561.0
SHD2_k127_1000984_2 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 327.0
SHD2_k127_1000984_3 PFAM Peptidase M22, glycoprotease K14742 - - 0.000000000000000000000000000316 127.0
SHD2_k127_1000984_4 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000003202 110.0
SHD2_k127_1000984_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000002149 105.0
SHD2_k127_1033653_0 drug transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 410.0
SHD2_k127_1033653_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008393 284.0
SHD2_k127_1033653_2 - - - - 0.000000000000000000000000000000000000000000000000000000426 196.0
SHD2_k127_1033653_3 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000001659 169.0
SHD2_k127_1033653_4 Histidine kinase - - - 0.0000000000009867 76.0
SHD2_k127_1047111_0 Prokaryotic cytochrome b561 - - - 0.0 1026.0
SHD2_k127_1047111_1 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 417.0
SHD2_k127_1047111_10 Protein of unknown function (DUF507) - - - 0.0005888 47.0
SHD2_k127_1047111_2 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 389.0
SHD2_k127_1047111_3 Histidine ammonia-lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 379.0
SHD2_k127_1047111_4 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000005714 254.0
SHD2_k127_1047111_5 (Rhomboid) family K07059 - - 0.00000000000000000000000000000000000000000000000000000000000001086 223.0
SHD2_k127_1047111_6 Belongs to the DapA family - - - 0.000000000000000000000000000000000000000001952 174.0
SHD2_k127_1047111_7 TIGRFAM TIGR00725 family protein K06966 - 3.2.2.10 0.00000000000000000000000000000000001029 142.0
SHD2_k127_1047111_8 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000001022 128.0
SHD2_k127_1047111_9 Protein of unknown function (DUF507) K09804 - - 0.000006036 55.0
SHD2_k127_1049395_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 2.25e-219 709.0
SHD2_k127_1049395_1 Bacterial regulatory protein, Fis family K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 471.0
SHD2_k127_1049395_2 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 458.0
SHD2_k127_1049395_3 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 364.0
SHD2_k127_1049395_4 Domains HisKA, HATPase_c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008108 341.0
SHD2_k127_1049395_5 Phosphoglucose isomerase K00616,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000004331 254.0
SHD2_k127_1049395_6 mRNA catabolic process K06950 - - 0.00000000000000000000000000000000000000000000504 181.0
SHD2_k127_1049395_7 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000928 143.0
SHD2_k127_1049395_8 PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.00000000000000000000000000006968 124.0
SHD2_k127_1049395_9 Heavy metal translocating P-type atpase K17686 - 3.6.3.54 0.000007579 58.0
SHD2_k127_1060110_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 5.095e-247 778.0
SHD2_k127_1060110_1 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 328.0
SHD2_k127_1060110_2 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000013 266.0
SHD2_k127_1060110_3 PFAM regulatory protein TetR - - - 0.000000983 56.0
SHD2_k127_1063571_0 oxidoreductase K00311,K00313 - 1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 608.0
SHD2_k127_1063571_1 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 417.0
SHD2_k127_1063571_2 electron transfer activity K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 412.0
SHD2_k127_1063571_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 306.0
SHD2_k127_1063571_4 - - - - 0.0000000000000004328 91.0
SHD2_k127_1063747_0 Protein of unknown function, DUF255 K06888 - - 2.644e-206 667.0
SHD2_k127_1063747_1 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 7.456e-203 650.0
SHD2_k127_1063747_2 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 351.0
SHD2_k127_1063747_3 spermidine synthase activity K00797 GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 353.0
SHD2_k127_1063747_4 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000004675 229.0
SHD2_k127_1063747_5 Putative zinc-finger - - - 0.0001715 54.0
SHD2_k127_1063747_6 COG0457 FOG TPR repeat - - - 0.0007001 53.0
SHD2_k127_1063747_7 TIGRFAM parallel beta-helix repeat (two copies) - - - 0.0008583 52.0
SHD2_k127_1070663_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1270.0
SHD2_k127_1070663_1 Tricorn protease PDZ domain K08676 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 544.0
SHD2_k127_1070663_2 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 346.0
SHD2_k127_1070663_3 Inositol monophosphatase family K01092,K05602 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008934,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016053,GO:0016137,GO:0016138,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0052745,GO:0052803,GO:0052834,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659 3.1.3.15,3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000002667 220.0
SHD2_k127_1070663_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000007909 227.0
SHD2_k127_1070663_5 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000002511 183.0
SHD2_k127_1070663_6 PFAM Aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000004239 181.0
SHD2_k127_1070663_7 Nucleotidyl transferase - - - 0.0000000000000000000000001134 118.0
SHD2_k127_1070663_8 - - - - 0.000000000000000000007324 104.0
SHD2_k127_1070663_9 DNA polymerase K02347 - - 0.000000000000000026 86.0
SHD2_k127_1090704_0 Involved in the tonB-independent uptake of proteins - - - 7.978e-220 712.0
SHD2_k127_1090704_1 PFAM Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000001775 139.0
SHD2_k127_1095554_0 Endopeptidase La K04076 - 3.4.21.53 9.867e-233 747.0
SHD2_k127_1095554_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 6.563e-221 694.0
SHD2_k127_1095554_10 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
SHD2_k127_1095554_11 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000000000000000192 199.0
SHD2_k127_1095554_12 PFAM regulatory protein, LysR - - - 0.00000000000000000000000000000000000000157 159.0
SHD2_k127_1095554_13 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000002079 151.0
SHD2_k127_1095554_14 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.00000000000000000000000000000001053 140.0
SHD2_k127_1095554_15 Acetyltransferase (GNAT) domain K01246 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 3.2.2.20 0.00000000000000000000012 109.0
SHD2_k127_1095554_16 - - - - 0.00000000000001171 86.0
SHD2_k127_1095554_17 - - - - 0.00000002359 65.0
SHD2_k127_1095554_18 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000002053 64.0
SHD2_k127_1095554_2 synthase K01858 - 5.5.1.4 1.124e-212 667.0
SHD2_k127_1095554_3 Peptidase, M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009398 580.0
SHD2_k127_1095554_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002803 574.0
SHD2_k127_1095554_5 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 548.0
SHD2_k127_1095554_6 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 404.0
SHD2_k127_1095554_7 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 350.0
SHD2_k127_1095554_8 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 310.0
SHD2_k127_1095554_9 Glycine cleavage H-protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 287.0
SHD2_k127_1099878_0 undecaprenyl-diphosphatase activity K06153 GO:0006950,GO:0008150,GO:0050896,GO:0051409 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000001393 228.0
SHD2_k127_1099878_1 Tryptophan synthase alpha chain K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000225 207.0
SHD2_k127_1099878_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000001429 221.0
SHD2_k127_1099878_3 Histidine kinase K02668,K07709 - 2.7.13.3 0.00000000000000000000003614 112.0
SHD2_k127_1143864_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 8.48e-217 687.0
SHD2_k127_1143864_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006331 278.0
SHD2_k127_1143864_2 Outer membrane protein beta-barrel domain - - - 0.0003014 47.0
SHD2_k127_1161849_0 PFAM basic membrane lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002992 385.0
SHD2_k127_1161849_1 Phosphoribulokinase / Uridine kinase family K00855,K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19,2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000004462 261.0
SHD2_k127_1161849_2 Thymidine kinase K00857 GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000007059 242.0
SHD2_k127_1161849_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760,K15780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000139 214.0
SHD2_k127_1161849_4 deoxynucleoside kinase - - - 0.000000000000000000000000000000000000000000000000000004551 204.0
SHD2_k127_1161849_5 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K20447 - 1.17.1.5 0.00000000000000000000000000000000003265 142.0
SHD2_k127_1161849_6 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.00000000000000009476 84.0
SHD2_k127_1162023_0 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000001689 184.0
SHD2_k127_1162023_1 D-glucuronyl C5-epimerase C-terminus - - - 0.0000000000000000000000000000000000247 153.0
SHD2_k127_1162023_2 NAD-dependent aldehyde dehydrogenases K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000001688 70.0
SHD2_k127_1162023_3 PFAM DivIVA family protein K04074 - - 0.0000001914 53.0
SHD2_k127_116255_0 cystathionine gamma-synthase activity K01739,K01758,K01760,K01761 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 496.0
SHD2_k127_116255_1 sequence-specific DNA binding K01697,K01738 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 2.5.1.47,4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009216 467.0
SHD2_k127_116255_10 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000001159 142.0
SHD2_k127_116255_11 JAB/MPN domain - - - 0.00000000000000000000000000000004972 131.0
SHD2_k127_116255_12 ThiS family K03636 - - 0.00000000000000000000000004697 111.0
SHD2_k127_116255_13 TM2 domain - - - 0.0000000000000000000000101 104.0
SHD2_k127_116255_14 - - - - 0.000000000000000000001545 105.0
SHD2_k127_116255_15 Histidine kinase - - - 0.0000000000000003206 92.0
SHD2_k127_116255_16 HEPN domain - - - 0.000000005577 63.0
SHD2_k127_116255_17 phosphorelay signal transduction system - - - 0.0009392 49.0
SHD2_k127_116255_2 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 445.0
SHD2_k127_116255_3 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 394.0
SHD2_k127_116255_4 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000008276 216.0
SHD2_k127_116255_5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000000005401 205.0
SHD2_k127_116255_6 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000003144 220.0
SHD2_k127_116255_7 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000002142 202.0
SHD2_k127_116255_8 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000001053 192.0
SHD2_k127_116255_9 nucleotide catabolic process - - - 0.0000000000000000000000000000000000000004792 164.0
SHD2_k127_1172961_0 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 403.0
SHD2_k127_1172961_1 Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 351.0
SHD2_k127_1172961_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008806 278.0
SHD2_k127_1172961_3 Belongs to the peptidase S11 family K01286,K07258 GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000001989 265.0
SHD2_k127_1172961_4 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000001082 220.0
SHD2_k127_1172961_5 ACR, YhhQ family COG1738 K09125 - - 0.000000000000000000000000000000000000000007051 164.0
SHD2_k127_1172961_6 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000000000000000000000000000001391 131.0
SHD2_k127_1172961_7 carboxylic ester hydrolase activity - - - 0.000000001342 68.0
SHD2_k127_118505_0 7TM-HD extracellular K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007575 327.0
SHD2_k127_118505_1 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K07042 - 3.5.4.5 0.00000000000000000000003306 104.0
SHD2_k127_1189318_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 2.348e-204 656.0
SHD2_k127_1189318_1 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000002143 243.0
SHD2_k127_1189318_3 N-acetyltransferase - - - 0.000000000000000000003359 108.0
SHD2_k127_1189318_5 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000004515 65.0
SHD2_k127_1199835_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000001142 284.0
SHD2_k127_1199835_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000003195 234.0
SHD2_k127_1199835_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000002108 118.0
SHD2_k127_1199835_3 Phosphatidylglycerophosphatase A K01095 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 0.0000000000000000000002062 103.0
SHD2_k127_121081_0 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 480.0
SHD2_k127_121081_1 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000002075 234.0
SHD2_k127_121081_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000001705 116.0
SHD2_k127_1236141_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 5.325e-299 945.0
SHD2_k127_1236141_1 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 291.0
SHD2_k127_1236141_2 PFAM asparagine synthase K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001162 250.0
SHD2_k127_1236141_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000002386 224.0
SHD2_k127_1236141_4 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000000000125 130.0
SHD2_k127_1236141_5 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000005069 129.0
SHD2_k127_1236141_6 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000004464 117.0
SHD2_k127_1236141_7 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000002325 100.0
SHD2_k127_1236141_8 STAS domain K04749 - - 0.00000000000000000002584 98.0
SHD2_k127_125551_0 benzoyl-CoA reductase K04113 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 597.0
SHD2_k127_125551_1 BadF/BadG/BcrA/BcrD ATPase family K04114 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 459.0
SHD2_k127_125551_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 425.0
SHD2_k127_125551_3 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 302.0
SHD2_k127_125551_4 Alanine dehydrogenase/PNT, C-terminal domain K07538 - 1.1.1.368 0.00000000000000000000000000000000000000000000000000000000001139 212.0
SHD2_k127_125551_5 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000001774 127.0
SHD2_k127_1298194_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 481.0
SHD2_k127_1298194_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 470.0
SHD2_k127_1298194_2 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 374.0
SHD2_k127_1298194_3 SMART regulatory protein ArsR - - - 0.000000000000000000000004867 105.0
SHD2_k127_1298194_4 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.0000000000001445 83.0
SHD2_k127_1305541_0 PFAM Type II secretion system protein E K02283,K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 534.0
SHD2_k127_1305541_1 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 456.0
SHD2_k127_1305541_10 PFAM Flp Fap pilin component K02651 - - 0.00005188 48.0
SHD2_k127_1305541_2 Belongs to the GSP D family K02280 - - 0.0000000000000000000000000000000000000000000000000000002662 208.0
SHD2_k127_1305541_3 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000000000000005638 203.0
SHD2_k127_1305541_4 type II secretion system protein K12510 - - 0.00000000000000000000000000000000000000000000000000008285 198.0
SHD2_k127_1305541_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000001432 172.0
SHD2_k127_1305541_6 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000003541 168.0
SHD2_k127_1305541_7 PFAM SAF domain K02279 - - 0.0000000000000000000000000000000003059 143.0
SHD2_k127_1305541_8 PFAM Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.00000000000001744 81.0
SHD2_k127_1305541_9 TadE-like protein - - - 0.000000003401 69.0
SHD2_k127_130758_0 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 394.0
SHD2_k127_130758_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 375.0
SHD2_k127_130758_2 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000001123 197.0
SHD2_k127_1313410_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.379e-297 942.0
SHD2_k127_1313410_1 NADH ubiquinone oxidoreductase, NADH-binding K00124,K00335,K18331 - 1.12.1.3,1.6.5.3 4.619e-247 784.0
SHD2_k127_1313410_2 Putative Fe-S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 318.0
SHD2_k127_1313410_3 Thioredoxin-like [2Fe-2S] ferredoxin K05586 - 1.6.5.3 0.000000000000000000000000000000000000000000002299 171.0
SHD2_k127_1313410_4 PFAM ATP-binding region, ATPase domain protein - - - 0.000000000000000000000000000000000015 146.0
SHD2_k127_1313410_5 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 0.0000000000000000000000000000009831 127.0
SHD2_k127_1313410_6 PFAM DRTGG domain - - - 0.0000000000000000000000003745 110.0
SHD2_k127_1313410_7 DRTGG domain - - - 0.0000000000000000007023 90.0
SHD2_k127_1313798_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 4.175e-321 1002.0
SHD2_k127_1313798_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000002694 78.0
SHD2_k127_1313798_2 Protein of unknown function (DUF3179) - - - 0.0000000008194 69.0
SHD2_k127_1320811_0 hmm pf01447 K01400,K01401 - 3.4.24.28,3.4.24.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000261 288.0
SHD2_k127_1320811_1 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000002405 139.0
SHD2_k127_1328330_0 XdhC and CoxI family K07402 - - 0.00000000000000000000000000000000000000000000000000000001494 207.0
SHD2_k127_1328330_1 Selenium-dependent molybdenum hydroxylase system protein, YqeB family K07402 - - 0.0000000000000000000000000000003086 141.0
SHD2_k127_1328330_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.000000000000000000000000001365 128.0
SHD2_k127_1328330_3 Mo-molybdopterin cofactor biosynthetic process - - - 0.000000000000001302 87.0
SHD2_k127_1328330_4 aldehyde oxidase and xanthine dehydrogenase a b hammerhead - - - 0.000000000000002608 76.0
SHD2_k127_1455737_0 PFAM glycoside hydrolase family 77 K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 587.0
SHD2_k127_1455737_1 Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 354.0
SHD2_k127_1455737_2 Linear amide C-N hydrolases, choloylglycine hydrolase family K01442 - 3.5.1.24 0.00000000000000000000000000000000000000000000000000000001303 219.0
SHD2_k127_1455737_3 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.000000000000000000000000004961 128.0
SHD2_k127_1455737_4 N-Acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000001466 68.0
SHD2_k127_1461098_0 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 312.0
SHD2_k127_1461098_1 Peptide-methionine (R)-S-oxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000729 200.0
SHD2_k127_1461098_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000145 167.0
SHD2_k127_1482143_0 Belongs to the TPP enzyme family K00156 - 1.2.5.1 7.618e-300 929.0
SHD2_k127_1482143_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 4.012e-254 811.0
SHD2_k127_1482143_2 Protein involved in amylo-alpha-1,6-glucosidase activity and glycogen biosynthetic process - - - 4.272e-196 641.0
SHD2_k127_1482143_3 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 358.0
SHD2_k127_1482143_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 344.0
SHD2_k127_1482143_5 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000008967 213.0
SHD2_k127_1482143_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000001343 174.0
SHD2_k127_1482143_7 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000001092 106.0
SHD2_k127_1482143_8 Bacterial protein of unknown function (DUF853) K06915 - - 0.000000000000001825 77.0
SHD2_k127_1482143_9 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.00000000000002255 79.0
SHD2_k127_1533807_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 363.0
SHD2_k127_1533807_1 amino acid activation for nonribosomal peptide biosynthetic process K20952 - - 0.00000000000000000000000000000000000000000000000000000009967 213.0
SHD2_k127_1533807_2 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000529 207.0
SHD2_k127_1533807_3 diguanylate cyclase - - - 0.00000000000000000000000002539 121.0
SHD2_k127_1533807_5 Protein of unknown function, DUF488 - - - 0.0000005972 53.0
SHD2_k127_1533807_6 domain protein - - - 0.0005712 47.0
SHD2_k127_1534255_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 2.652e-283 889.0
SHD2_k127_1534255_1 Psort location OuterMembrane, score - - - 0.0003721 53.0
SHD2_k127_1543946_0 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 349.0
SHD2_k127_1543946_1 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 331.0
SHD2_k127_1543946_2 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000001683 211.0
SHD2_k127_1543946_3 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000001108 163.0
SHD2_k127_1543946_4 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000007275 132.0
SHD2_k127_1543946_5 Carbamoyltransferase C-terminus K00612 - - 0.000000000000000000000000006062 120.0
SHD2_k127_1548757_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 535.0
SHD2_k127_1548757_1 DNA polymerase LigD, polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008462 334.0
SHD2_k127_1548757_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001152 235.0
SHD2_k127_1548757_3 DNA polymerase Ligase (LigD) - - - 0.000000000000000000000000000000000000000000000000000000001063 222.0
SHD2_k127_1548757_4 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000001508 193.0
SHD2_k127_1548757_5 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000001887 185.0
SHD2_k127_1548757_6 Ku70/Ku80 beta-barrel domain - - - 0.000000000000000000000000000000000000000005122 171.0
SHD2_k127_1548757_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000008605 163.0
SHD2_k127_1548757_8 - - - - 0.0000000000000000000000000000001274 130.0
SHD2_k127_157602_0 Elongation factor Tu domain 2 K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 524.0
SHD2_k127_157602_1 Belongs to the EPSP synthase family. MurA subfamily K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009379 470.0
SHD2_k127_157602_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006036 395.0
SHD2_k127_157602_3 Psort location CytoplasmicMembrane, score 10.00 - - - 0.000000000000000000000000000000000000000000000000000000000000000001349 235.0
SHD2_k127_157602_4 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000009634 206.0
SHD2_k127_1586247_0 3-isopropylmalate dehydratase activity K01703 - 4.2.1.33,4.2.1.35 3.731e-206 648.0
SHD2_k127_1586247_1 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 593.0
SHD2_k127_1586247_2 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 588.0
SHD2_k127_1586247_3 HMGL-like K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 353.0
SHD2_k127_1586247_4 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000001511 222.0
SHD2_k127_1586247_5 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000173 199.0
SHD2_k127_1586247_6 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000000000000000000000000000001636 161.0
SHD2_k127_1586247_7 EamA-like transporter family - - - 0.0000000000000000000000000000000000000002044 165.0
SHD2_k127_1586247_8 TIGRFAM Transcriptional regulator, Rrf2 - - - 0.000000000000000000000002477 113.0
SHD2_k127_158743_0 winged helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 564.0
SHD2_k127_158743_1 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 375.0
SHD2_k127_158743_2 Wzt C-terminal domain K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 331.0
SHD2_k127_158743_3 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 313.0
SHD2_k127_158743_4 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 299.0
SHD2_k127_158743_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007428 293.0
SHD2_k127_158743_6 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003202 274.0
SHD2_k127_158743_7 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000216 254.0
SHD2_k127_158743_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000008434 216.0
SHD2_k127_158743_9 cellulose binding - - - 0.00000000000000000000000000001727 135.0
SHD2_k127_1589688_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 359.0
SHD2_k127_1589688_1 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 345.0
SHD2_k127_1589688_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000745 199.0
SHD2_k127_1589688_3 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K16785 - - 0.0000000000000000000002779 108.0
SHD2_k127_1589688_4 Oxidoreductase - - - 0.00000001203 56.0
SHD2_k127_1599165_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 563.0
SHD2_k127_1599165_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 439.0
SHD2_k127_1599165_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000895 209.0
SHD2_k127_1599165_3 Glycine cleavage H-protein K02437 - - 0.0000000000000000000000000000000000000000000003007 169.0
SHD2_k127_1611434_0 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843 - - 0.0000000000000000000000000000000000000000000003271 183.0
SHD2_k127_1611434_1 O-Antigen ligase K18814 - - 0.000000000001448 80.0
SHD2_k127_165664_0 Isocitrate lyase K01637 GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350 4.1.3.1 2.154e-286 897.0
SHD2_k127_165664_1 Belongs to the malate synthase family K01638 - 2.3.3.9 1.083e-281 882.0
SHD2_k127_166437_0 Urocanase C-terminal domain K01712 - 4.2.1.49 2.763e-268 836.0
SHD2_k127_166437_1 General secretory system II protein E domain protein K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000855 618.0
SHD2_k127_166437_10 Tetratricopeptide repeat - - - 0.000000000000006529 87.0
SHD2_k127_166437_11 ComEA protein K02237 - - 0.00000000000005505 79.0
SHD2_k127_166437_12 Tetratricopeptide repeats - - - 0.0000000005716 71.0
SHD2_k127_166437_13 Psort location CytoplasmicMembrane, score K16927 - - 0.000009908 55.0
SHD2_k127_166437_2 Formiminotransferase-cyclodeaminase K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 474.0
SHD2_k127_166437_3 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 460.0
SHD2_k127_166437_4 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 393.0
SHD2_k127_166437_5 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07713,K07714,K19641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008361 387.0
SHD2_k127_166437_6 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 296.0
SHD2_k127_166437_7 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000003893 250.0
SHD2_k127_166437_8 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.000000000000000000000000000000000000000000000000000000000002209 212.0
SHD2_k127_166437_9 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000000001828 214.0
SHD2_k127_17274_0 Alpha-2-Macroglobulin K06894 - - 0.0000000000000000000000000000000000000000000000000004289 210.0
SHD2_k127_17274_1 PFAM Uncharacterised BCR, COG1649 - - - 0.0000000000107 69.0
SHD2_k127_1737991_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000002323 267.0
SHD2_k127_1737991_1 ADP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007012 280.0
SHD2_k127_1737991_2 Cupin 2, conserved barrel - - - 0.0000000000000000000000000000000000000000000000000003658 187.0
SHD2_k127_1737991_3 Glyoxalase-like domain K06996 - - 0.00000000000000000000000007349 109.0
SHD2_k127_1737991_4 ABC-2 family transporter protein K09696 - - 0.0000005956 57.0
SHD2_k127_1741633_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 6.6e-214 683.0
SHD2_k127_1741633_1 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 492.0
SHD2_k127_1741633_2 PFAM CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000001492 252.0
SHD2_k127_1741633_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000002027 224.0
SHD2_k127_1741633_4 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000006534 209.0
SHD2_k127_1741633_5 Transcriptional - - - 0.0000000000000000000000000000004543 126.0
SHD2_k127_1741633_6 Lipid A biosynthesis K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.265 0.0000001523 63.0
SHD2_k127_1774635_0 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001737 143.0
SHD2_k127_1774635_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000003096 132.0
SHD2_k127_1774635_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000004492 116.0
SHD2_k127_1774635_3 Bifunctional nuclease K08999 - - 0.0000000000000000000003467 103.0
SHD2_k127_1774635_4 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000009722 98.0
SHD2_k127_1774635_5 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000004718 90.0
SHD2_k127_1774635_6 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000007596 74.0
SHD2_k127_1774635_7 protein trimerization - - - 0.00002459 56.0
SHD2_k127_177719_0 PFAM helicase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 480.0
SHD2_k127_177719_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 337.0
SHD2_k127_177719_2 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005362 294.0
SHD2_k127_177719_3 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000002547 123.0
SHD2_k127_177719_4 Tetratricopeptide repeat - - - 0.0000008247 60.0
SHD2_k127_1783798_0 ABC 3 transport family K09816,K09819 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 349.0
SHD2_k127_1783798_1 Zinc-uptake complex component A periplasmic K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 316.0
SHD2_k127_1783798_2 ABC transporter K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 296.0
SHD2_k127_1783798_3 Multicopper oxidase K04753 - - 0.0000000000000000000000000000000000000000000000005665 200.0
SHD2_k127_1783798_4 Ferric uptake regulator family K03711 - - 0.00000000000000000000001763 105.0
SHD2_k127_1783798_5 Protein of unknown function (DUF3179) - - - 0.0000000000000001156 88.0
SHD2_k127_1783798_6 cellulose binding K00505 - 1.14.18.1 0.0000000000001228 85.0
SHD2_k127_1783798_7 Methyltransferase domain - - - 0.00002788 56.0
SHD2_k127_1794844_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009871 286.0
SHD2_k127_1794844_1 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008348 276.0
SHD2_k127_1794844_2 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000003517 233.0
SHD2_k127_1794844_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000003346 175.0
SHD2_k127_1794844_4 receptor K02014,K16089 - - 0.000000000000000000000000000000699 141.0
SHD2_k127_1794844_5 DinB family - - - 0.0000000000000000000000008001 111.0
SHD2_k127_1794844_6 - - - - 0.000000000000000000000003642 115.0
SHD2_k127_1794844_7 ABC transporter substrate binding protein K01989 - - 0.000000000000000009449 94.0
SHD2_k127_181524_0 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000002817 151.0
SHD2_k127_181524_1 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000001492 108.0
SHD2_k127_181524_2 Aminotransferase class I and II - - - 0.0000000000188 70.0
SHD2_k127_181524_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000016 61.0
SHD2_k127_1855303_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 535.0
SHD2_k127_1855303_1 Cytochrome bd-type quinol oxidase, subunit 2 K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 318.0
SHD2_k127_1855303_2 metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 309.0
SHD2_k127_18794_0 extracellular matrix structural constituent - - - 0.000001581 61.0
SHD2_k127_1887372_0 lyase activity K01387,K03301 - 3.4.24.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 372.0
SHD2_k127_1887372_1 PFAM Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000002284 264.0
SHD2_k127_1887372_2 cellulose binding - - - 0.0000000002432 72.0
SHD2_k127_1887372_3 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000002715 63.0
SHD2_k127_1887372_4 Hypothetical glycosyl hydrolase family 15 - - - 0.00004403 55.0
SHD2_k127_1901573_0 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 427.0
SHD2_k127_1901573_1 - - - - 0.0000000000000000000000000000000000000000000000001731 185.0
SHD2_k127_1901573_2 AIR carboxylase K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000005247 180.0
SHD2_k127_1901573_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000002547 163.0
SHD2_k127_1901573_4 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000000000000003459 145.0
SHD2_k127_1901573_5 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.000000000000000000000000000003684 133.0
SHD2_k127_1901573_6 cellulase activity - - - 0.000000001226 70.0
SHD2_k127_19020_0 Aminotransferase class I and II K00639,K21784 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 362.0
SHD2_k127_19020_1 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006277 332.0
SHD2_k127_19020_2 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 301.0
SHD2_k127_19020_3 NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001984 285.0
SHD2_k127_19020_4 PFAM Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000000000000000219 186.0
SHD2_k127_19020_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000001195 128.0
SHD2_k127_19020_6 PFAM UbiA prenyltransferase family K17105 - 2.5.1.42 0.000000000000000000000000001257 114.0
SHD2_k127_19020_7 polyketide synthase K21792 - - 0.00000000000000000000000004241 121.0
SHD2_k127_19020_9 Tetratricopeptide repeat - - - 0.00004054 57.0
SHD2_k127_1903306_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 365.0
SHD2_k127_1903306_1 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000001931 214.0
SHD2_k127_1903306_2 amino acid K01999 - - 0.0000000000000003437 91.0
SHD2_k127_1922365_0 PFAM glycosyl transferase family 51 K05366,K21464 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000946 457.0
SHD2_k127_1922365_1 TIGRFAM Pyrimidine-nucleoside phosphorylase K00756,K00758 - 2.4.2.2,2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005585 418.0
SHD2_k127_1922365_2 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000001887 217.0
SHD2_k127_1922365_3 efflux transmembrane transporter activity - - - 0.000004811 57.0
SHD2_k127_1922965_0 two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 448.0
SHD2_k127_1922965_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000009272 177.0
SHD2_k127_1922965_2 Polymer-forming cytoskeletal - - - 0.0001663 49.0
SHD2_k127_1922965_3 LVIVD repeat K01179 - 3.2.1.4 0.0005583 51.0
SHD2_k127_1940481_0 Electron transfer flavoprotein K03522 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 304.0
SHD2_k127_1940481_1 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000007345 229.0
SHD2_k127_1940481_2 acyl-coa hydrolase K01073 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.2.20 0.0000000000000000000000000000000000000000000004178 185.0
SHD2_k127_198293_0 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000002844 224.0
SHD2_k127_198293_1 Uracil DNA glycosylase superfamily K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000004509 77.0
SHD2_k127_198293_2 anaphase-promoting complex binding - - - 0.000000000001611 76.0
SHD2_k127_198293_3 Winged helix DNA-binding domain - - - 0.000000575 62.0
SHD2_k127_2013565_0 - - - - 0.0000000006614 72.0
SHD2_k127_2013565_1 Amino acid permease K03294 - - 0.0009153 44.0
SHD2_k127_2020212_0 Sigma-54 interaction domain K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006406 281.0
SHD2_k127_2020212_1 CAAX protease self-immunity K07052 - - 0.000000000000000000000001236 121.0
SHD2_k127_2020212_2 Peptidase M56, BlaR1 - - - 0.0002098 55.0
SHD2_k127_2051267_0 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007814 258.0
SHD2_k127_2051267_1 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000001497 216.0
SHD2_k127_2051267_2 ATP cob(I)alamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000003662 195.0
SHD2_k127_2051267_4 aminopeptidase N - - - 0.000005017 57.0
SHD2_k127_2075891_0 Glycosyl hydrolase family 57 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 473.0
SHD2_k127_2075891_1 PFAM Peptidase M16 inactive domain K07263 - - 0.000000000000000000003713 98.0
SHD2_k127_2092243_0 Pfam Zn-finger in ubiquitin-hydrolases and other protein K03455 - - 0.0000000000000000000000000000000000000000007715 160.0
SHD2_k127_2092243_1 - - - - 0.00000000000000000000000003064 109.0
SHD2_k127_2092243_2 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.000000001057 70.0
SHD2_k127_2092243_3 TonB-dependent receptor plug - - - 0.000002167 61.0
SHD2_k127_209456_0 MutL protein K00854 - 2.7.1.17 9.899e-261 822.0
SHD2_k127_209456_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000005372 220.0
SHD2_k127_209456_2 - - - - 0.000000000000000000003122 96.0
SHD2_k127_209541_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 400.0
SHD2_k127_209541_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 358.0
SHD2_k127_209541_2 PFAM HhH-GPD K07457 - - 0.000000000000000000000000000000000000000000000000000000000000000004244 235.0
SHD2_k127_209541_3 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000006613 225.0
SHD2_k127_209541_4 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.000000000000000000000000000000000000000000001543 178.0
SHD2_k127_209541_5 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000191 172.0
SHD2_k127_209541_6 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000005344 164.0
SHD2_k127_209541_7 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000004006 112.0
SHD2_k127_209541_8 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.000144 50.0
SHD2_k127_21156_0 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 459.0
SHD2_k127_21156_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 402.0
SHD2_k127_21156_10 Fumarase C-terminus K01676 - 4.2.1.2 0.0000000004224 61.0
SHD2_k127_21156_11 Putative zinc-finger - - - 0.000000007545 59.0
SHD2_k127_21156_2 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 314.0
SHD2_k127_21156_3 Related to alanyl-tRNA synthetase HxxxH domain K01872,K07050 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000007371 250.0
SHD2_k127_21156_4 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000001962 197.0
SHD2_k127_21156_5 RNA polymerase sigma factor K03088 - - 0.0000000000000000000000000000000000000001032 162.0
SHD2_k127_21156_6 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000001134 130.0
SHD2_k127_21156_7 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000001301 113.0
SHD2_k127_21156_8 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000003264 93.0
SHD2_k127_21156_9 C4-type zinc ribbon domain K07164 - - 0.000000000002695 71.0
SHD2_k127_2130284_0 Ribosomal protein S1 K02945,K03527,K12132 GO:0005575,GO:0005576,GO:0018995,GO:0020003,GO:0030430,GO:0033643,GO:0033646,GO:0033655,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0065010 1.17.7.4,2.7.11.1 6.502e-224 712.0
SHD2_k127_2130284_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007121 362.0
SHD2_k127_2130284_2 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000003445 99.0
SHD2_k127_2130284_3 Histidine kinase - - - 0.0004444 48.0
SHD2_k127_21444_0 Peptidase M36 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009474 267.0
SHD2_k127_21444_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000003094 184.0
SHD2_k127_21444_2 Fungalysin metallopeptidase (M36) - - - 0.000003155 61.0
SHD2_k127_21444_3 bacterial-type flagellum-dependent cell motility K01119,K06113,K12685,K20276 - 3.1.3.6,3.1.4.16,3.2.1.99 0.000009526 59.0
SHD2_k127_217046_0 ATP synthase alpha/beta family, beta-barrel domain K02412 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 536.0
SHD2_k127_217046_1 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 370.0
SHD2_k127_217046_2 FliG N-terminal domain K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000172 291.0
SHD2_k127_217046_3 The M ring may be actively involved in energy transduction K02409 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003766 280.0
SHD2_k127_217046_4 Belongs to the flagella basal body rod proteins family K02388 - - 0.00000000000000000000000000003253 121.0
SHD2_k127_217046_5 Flagellar hook-basal body complex protein FliE K02408 - - 0.0000000000000000002666 90.0
SHD2_k127_217046_6 Flagellar assembly protein FliH K02411 - - 0.00000000000002868 83.0
SHD2_k127_217046_7 bacterial-type flagellum-dependent cell motility K02387 - - 0.0001317 49.0
SHD2_k127_217046_8 - - - - 0.0003695 46.0
SHD2_k127_217715_0 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000004125 161.0
SHD2_k127_217715_1 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000005128 156.0
SHD2_k127_217715_2 Histidine kinase - - - 0.0000000000000000000000000000000001145 154.0
SHD2_k127_217715_3 Polysaccharide biosynthesis C-terminal domain - - - 0.000000000000000003064 88.0
SHD2_k127_217715_4 - - - - 0.0000005564 55.0
SHD2_k127_2202319_0 PFAM Glycoside hydrolase, family 38 K01191,K15524 - 3.2.1.170,3.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 388.0
SHD2_k127_2202319_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008144 325.0
SHD2_k127_2202319_2 lipolytic protein G-D-S-L family K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000002223 250.0
SHD2_k127_2202319_4 converts alpha-aldose to the beta-anomer - - - 0.000000000000000000000000000009672 130.0
SHD2_k127_2202319_5 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000346 110.0
SHD2_k127_2202319_6 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000001601 100.0
SHD2_k127_2202319_7 - - - - 0.0000000000003719 74.0
SHD2_k127_2212175_0 PFAM UBA THIF-type NAD FAD binding protein K21029,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 438.0
SHD2_k127_2212175_1 O-methyltransferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000007221 222.0
SHD2_k127_2212175_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000003231 165.0
SHD2_k127_2212175_3 PFAM Rhomboid family protein - - - 0.00000000000000000000000000000000000000004758 164.0
SHD2_k127_2212175_4 nUDIX hydrolase K03574,K03575 - 3.6.1.55 0.0000000000000000000000000000004061 129.0
SHD2_k127_2212175_5 KR domain K00046 - 1.1.1.69 0.00000000000000004703 85.0
SHD2_k127_2223035_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 1.77e-232 730.0
SHD2_k127_2223035_1 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 307.0
SHD2_k127_2223035_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 294.0
SHD2_k127_2223035_3 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000002534 247.0
SHD2_k127_2223035_4 dCMP deaminase activity K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000006992 213.0
SHD2_k127_2223035_5 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000001723 178.0
SHD2_k127_2223035_6 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000002745 168.0
SHD2_k127_2223035_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000001656 149.0
SHD2_k127_2223035_8 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000292 130.0
SHD2_k127_2235125_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175,K00177,K00187 - 1.2.7.11,1.2.7.3,1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 533.0
SHD2_k127_2235125_1 Pyruvate:ferredoxin oxidoreductase core domain II K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 443.0
SHD2_k127_2235125_2 peroxiredoxin activity K03564,K07638 - 1.11.1.15,2.7.13.3 0.000000000000000000000000000000000000000002629 160.0
SHD2_k127_2235125_3 4 iron, 4 sulfur cluster binding K00176,K05524 - 1.2.7.3 0.00000000000000000000001989 102.0
SHD2_k127_22450_0 TIGRFAM RNA polymerase sigma-54 factor K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 354.0
SHD2_k127_22450_1 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 335.0
SHD2_k127_22450_2 PFAM ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007984 325.0
SHD2_k127_22450_3 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000003256 97.0
SHD2_k127_22450_4 system, fructose subfamily IIA component K02793,K02794 - 2.7.1.191 0.000000000000000002171 89.0
SHD2_k127_22450_5 Lipopolysaccharide-assembly, LptC-related K09774,K11719 - - 0.000000000008716 68.0
SHD2_k127_22450_6 PTS system mannose fructose sorbose family K02793,K02794 - 2.7.1.191 0.0000000001987 65.0
SHD2_k127_2262880_0 PFAM Prolyl oligopeptidase family - - - 7.028e-196 623.0
SHD2_k127_2262880_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 493.0
SHD2_k127_2262880_2 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 490.0
SHD2_k127_2262880_3 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 420.0
SHD2_k127_2262880_4 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000007368 265.0
SHD2_k127_2262880_5 - - - - 0.000000000000000000000000000000000000000000000000000000000724 216.0
SHD2_k127_2276147_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1037.0
SHD2_k127_2276147_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 7.693e-285 887.0
SHD2_k127_2276147_2 lysine biosynthetic process via aminoadipic acid - - - 2.197e-200 649.0
SHD2_k127_2276147_3 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 413.0
SHD2_k127_2276147_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000002745 272.0
SHD2_k127_2276147_5 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.0000000000000000000000000000000000000000000000000000004081 203.0
SHD2_k127_2276147_7 Protein of unknown function (DUF721) - - - 0.0000000000007804 73.0
SHD2_k127_2287113_0 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 353.0
SHD2_k127_2287113_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 307.0
SHD2_k127_2287113_2 WD40 domain protein beta Propeller - - - 0.0000000000000000000000000004384 130.0
SHD2_k127_230991_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 452.0
SHD2_k127_230991_1 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 376.0
SHD2_k127_230991_2 cellulase activity K01183 - 3.2.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007437 283.0
SHD2_k127_230991_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000019 252.0
SHD2_k127_230991_4 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000000000000002762 173.0
SHD2_k127_230991_5 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000002415 149.0
SHD2_k127_230991_6 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000231 162.0
SHD2_k127_230991_7 extracellular matrix structural constituent - - - 0.000000003616 68.0
SHD2_k127_230991_8 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K00587 - 2.1.1.100 0.0001211 45.0
SHD2_k127_2320585_0 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 615.0
SHD2_k127_2320585_1 MreB/Mbl protein K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 462.0
SHD2_k127_2320585_10 TIGRFAM rod shape-determining protein MreD K03571 - - 0.0000000003904 71.0
SHD2_k127_2320585_2 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 434.0
SHD2_k127_2320585_3 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000009747 270.0
SHD2_k127_2320585_4 NlpC P60 family - - - 0.000000000000000000000000000000000000008662 156.0
SHD2_k127_2320585_5 Peptidase M56 - - - 0.00000000000000000000000000000000000003436 163.0
SHD2_k127_2320585_6 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000001626 129.0
SHD2_k127_2320585_7 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000001094 123.0
SHD2_k127_2320585_8 - - - - 0.00000000000007224 83.0
SHD2_k127_2320585_9 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000214 84.0
SHD2_k127_2322483_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 529.0
SHD2_k127_2322483_1 Cytochrome C assembly protein - GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - 0.0000000000000000000000000000000000000000000000000000000004698 214.0
SHD2_k127_2322483_2 glutamyl-tRNA reductase activity K02407,K02492 GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 0.000000000000000000000000000000000000000000000000003581 188.0
SHD2_k127_2322483_3 PFAM ResB family protein K07399 - - 0.0000000000000000000000000000000000000000000002234 185.0
SHD2_k127_2322483_4 VanZ like family - - - 0.0000001206 59.0
SHD2_k127_2362026_0 Belongs to the peptidase M16 family K07263 - - 1.546e-308 993.0
SHD2_k127_2362026_1 Bacterial DNA topoisomeraes I ATP-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009473 576.0
SHD2_k127_2362026_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008176 341.0
SHD2_k127_2362026_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 307.0
SHD2_k127_2362026_4 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001343 275.0
SHD2_k127_2362026_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000003726 229.0
SHD2_k127_2362026_6 N-acetylglucosaminylinositol deacetylase activity K22135 - - 0.0000000000000000000000000294 118.0
SHD2_k127_2389884_0 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003539 284.0
SHD2_k127_2389884_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 0.0000000000000000002646 91.0
SHD2_k127_2389884_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000007308 68.0
SHD2_k127_2395285_0 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 531.0
SHD2_k127_2395285_1 ABC transporter C-terminal domain K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 439.0
SHD2_k127_2395285_2 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004739 309.0
SHD2_k127_2405077_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 502.0
SHD2_k127_2405077_1 Phenylacetate-CoA oxygenase subunit PaaA K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 396.0
SHD2_k127_2405077_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000004649 254.0
SHD2_k127_2405077_3 ABC transporter substrate-binding protein K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044464 - 0.000000000000000000000000000000001183 138.0
SHD2_k127_2405077_4 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.0000000000000000000000000456 119.0
SHD2_k127_2405077_5 Pfam:DUF59 K02612 - - 0.00000000000000000000001451 108.0
SHD2_k127_2405077_6 phenylacetate catabolic process K02610 - - 0.00000000000008934 74.0
SHD2_k127_2405077_7 metal-sulfur cluster biosynthetic enzyme - - - 0.00000000194 61.0
SHD2_k127_2415675_0 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007227 273.0
SHD2_k127_2415675_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000576 268.0
SHD2_k127_2415675_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000004673 261.0
SHD2_k127_2415675_3 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000006541 163.0
SHD2_k127_2415675_4 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000003848 143.0
SHD2_k127_2415675_5 helix_turn_helix, mercury resistance - - - 0.0000000000000000001447 95.0
SHD2_k127_2415675_6 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000003113 85.0
SHD2_k127_2415675_7 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000002415 60.0
SHD2_k127_2426170_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00066 - 1.1.1.132 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 451.0
SHD2_k127_2426170_1 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000008334 232.0
SHD2_k127_2426170_2 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000005707 150.0
SHD2_k127_2426170_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000003353 148.0
SHD2_k127_2437496_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 411.0
SHD2_k127_2437496_1 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000003639 209.0
SHD2_k127_2437496_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000007843 104.0
SHD2_k127_2444581_0 T4-like virus tail tube protein gp19 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005565 243.0
SHD2_k127_2444581_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000002888 229.0
SHD2_k127_2444581_2 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000003448 187.0
SHD2_k127_2444581_3 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000005757 189.0
SHD2_k127_2444581_4 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000000000000000000000000000003031 145.0
SHD2_k127_2444581_5 LVIVD repeat K01179 - 3.2.1.4 0.000000000000000001504 101.0
SHD2_k127_2444581_6 peptidase activity, acting on L-amino acid peptides K01179 - 3.2.1.4 0.0000000000004289 72.0
SHD2_k127_2493898_0 3-beta hydroxysteroid dehydrogenase isomerase - - - 0.0000000000000000000000000000000000007723 146.0
SHD2_k127_2493898_1 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.0000000000000000000000000000001892 140.0
SHD2_k127_2493898_2 type II secretion system protein K - - - 0.0000000000000000000000000000008812 139.0
SHD2_k127_2493898_3 Tetratricopeptide repeat - - - 0.000000000000000004642 96.0
SHD2_k127_2493898_4 Prokaryotic N-terminal methylation motif K02672 - - 0.0000000002355 71.0
SHD2_k127_2493898_5 protein transport across the cell outer membrane K02457,K02458,K08084 - - 0.000002094 58.0
SHD2_k127_2493898_6 Prokaryotic N-terminal methylation motif K02671 - - 0.0000095 55.0
SHD2_k127_2526959_0 asparagine synthase K01953 - 6.3.5.4 7.887e-212 677.0
SHD2_k127_2526959_1 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007876 492.0
SHD2_k127_2526959_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 463.0
SHD2_k127_2526959_3 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000001366 248.0
SHD2_k127_2526959_4 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000000002568 146.0
SHD2_k127_2526959_5 Phosphopantetheine attachment site - - - 0.00000000000000000005727 93.0
SHD2_k127_2526959_6 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000605 94.0
SHD2_k127_2526959_7 YceI-like domain - - - 0.000000000000000000111 97.0
SHD2_k127_2526959_8 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000004307 77.0
SHD2_k127_2567156_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 3.734e-244 761.0
SHD2_k127_2567156_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 459.0
SHD2_k127_2567156_10 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000001438 120.0
SHD2_k127_2567156_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000001668 94.0
SHD2_k127_2567156_12 cellulose binding K00505 - 1.14.18.1 0.000000000000005732 88.0
SHD2_k127_2567156_13 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000000001618 79.0
SHD2_k127_2567156_14 Domain of unknown function DUF11 - - - 0.0002665 53.0
SHD2_k127_2567156_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001814 278.0
SHD2_k127_2567156_3 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004764 284.0
SHD2_k127_2567156_4 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007853 254.0
SHD2_k127_2567156_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000741 257.0
SHD2_k127_2567156_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000005434 244.0
SHD2_k127_2567156_7 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000001514 174.0
SHD2_k127_2567156_8 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000002466 143.0
SHD2_k127_2567156_9 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000001546 126.0
SHD2_k127_2586556_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 494.0
SHD2_k127_2586556_1 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 331.0
SHD2_k127_2586556_2 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000001024 114.0
SHD2_k127_2586556_3 COG0226 ABC-type phosphate transport system, periplasmic component - - - 0.00001535 53.0
SHD2_k127_2600059_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009918 299.0
SHD2_k127_2600059_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000945 184.0
SHD2_k127_2600059_2 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000002179 102.0
SHD2_k127_2602171_0 major facilitator superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002852 521.0
SHD2_k127_2602171_1 Auxiliary transport protein, membrane fusion protein (MFP) family protein K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005395 254.0
SHD2_k127_2602171_2 PFAM Phenazine biosynthesis PhzC PhzF protein - - - 0.00000000000000000000000000000000000000000000000000000000000001806 221.0
SHD2_k127_2629890_0 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 334.0
SHD2_k127_2629890_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000503 254.0
SHD2_k127_2629890_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000001155 232.0
SHD2_k127_2629890_3 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000006303 226.0
SHD2_k127_2629890_4 Kinase domain K12132 - 2.7.11.1 0.000000000000008026 84.0
SHD2_k127_263764_0 response regulator K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 406.0
SHD2_k127_263764_1 Abc transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 316.0
SHD2_k127_263764_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000003198 206.0
SHD2_k127_263764_3 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000001033 183.0
SHD2_k127_263764_4 NUDIX domain - - - 0.0000000000000000000004754 101.0
SHD2_k127_2643906_0 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 444.0
SHD2_k127_2775529_0 TonB-dependent receptor K16092 - - 0.000000000000000000000000000000000000000000000000000000684 216.0
SHD2_k127_2775529_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000001626 85.0
SHD2_k127_2775529_2 amine dehydrogenase activity K01224,K13372,K15229,K17285 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1,1.4.9.2,3.2.1.89 0.000000001978 70.0
SHD2_k127_2775529_3 Outer membrane protein beta-barrel domain - - - 0.000007061 56.0
SHD2_k127_2775529_4 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins K03286 - - 0.00002395 55.0
SHD2_k127_2808261_0 PFAM Uncharacterised protein family UPF0182 K09118 - - 1.647e-198 653.0
SHD2_k127_2808261_1 translation initiation factor activity K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003674 254.0
SHD2_k127_2808261_2 transmembrane transporter activity K03296 - - 0.000000000000000000000000000000000000000000002516 175.0
SHD2_k127_2808261_3 - - - - 0.000000000000000000000000000000000000000000002613 171.0
SHD2_k127_2808261_4 Permease for cytosine/purines, uracil, thiamine, allantoin K03457 - - 0.00000000000000000000000000000000000003554 146.0
SHD2_k127_2808261_5 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000008598 142.0
SHD2_k127_2808261_6 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000003627 114.0
SHD2_k127_282863_0 extracellular matrix structural constituent - - - 0.000000000000406 84.0
SHD2_k127_282863_1 cellulose binding K01179,K21449 - 3.2.1.4 0.0000000000996 76.0
SHD2_k127_2831255_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001027 305.0
SHD2_k127_2831255_1 PFAM Glycosyl transferases group 1 K20444 - - 0.00000000000000000000000000000000004457 146.0
SHD2_k127_2831255_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000072 115.0
SHD2_k127_2831255_3 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0002938 54.0
SHD2_k127_2833282_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 482.0
SHD2_k127_2833282_1 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 442.0
SHD2_k127_2833282_2 Integral membrane sensor signal transduction histidine kinase K07709,K13924 - 2.1.1.80,2.7.13.3,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 299.0
SHD2_k127_2833282_3 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000002953 271.0
SHD2_k127_2833282_4 Belongs to the peptidase S8 family - - - 0.00000000000006543 78.0
SHD2_k127_2839914_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0 1084.0
SHD2_k127_2839914_1 NAD+ binding K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001931 256.0
SHD2_k127_2839914_2 Putative glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001071 253.0
SHD2_k127_2839914_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 2.7.8.41 0.000000000000000003749 97.0
SHD2_k127_2839914_4 Lamin Tail Domain - - - 0.00000008711 64.0
SHD2_k127_2839914_5 Serine threonine protein kinase K12132 - 2.7.11.1 0.0005426 49.0
SHD2_k127_2840140_0 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 349.0
SHD2_k127_2840140_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000006733 196.0
SHD2_k127_2840140_2 Subtilase family - - - 0.000000000000000000000000000000000001508 158.0
SHD2_k127_2840140_3 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000005438 118.0
SHD2_k127_2840140_4 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000001625 61.0
SHD2_k127_2841780_0 4Fe-4S dicluster domain K00184 - - 1.437e-307 979.0
SHD2_k127_2841780_1 Polysulphide reductase, NrfD K00185 - - 1.496e-210 676.0
SHD2_k127_2841780_2 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000002418 239.0
SHD2_k127_2841780_3 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000000000000000001192 211.0
SHD2_k127_2841780_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000001939 67.0
SHD2_k127_284664_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 294.0
SHD2_k127_284664_1 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000009519 264.0
SHD2_k127_284664_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000001609 196.0
SHD2_k127_284664_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000001653 150.0
SHD2_k127_284664_4 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000000000575 111.0
SHD2_k127_284664_5 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000005362 110.0
SHD2_k127_284664_6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000000002116 110.0
SHD2_k127_284664_7 Belongs to the UPF0102 family K07460 - - 0.000000000000000004838 89.0
SHD2_k127_2936428_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 531.0
SHD2_k127_2936428_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008595 406.0
SHD2_k127_2936428_2 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 343.0
SHD2_k127_2936428_3 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.00000000000000000000000000000000000000000000000000000199 204.0
SHD2_k127_2936428_4 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000004481 190.0
SHD2_k127_2936428_5 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000000000000000000000000000000004102 176.0
SHD2_k127_2936428_6 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000008519 164.0
SHD2_k127_2936428_7 - - - - 0.000000000000000000000000000009856 129.0
SHD2_k127_2936428_8 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000004088 55.0
SHD2_k127_301921_0 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009697 290.0
SHD2_k127_301921_1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006375 263.0
SHD2_k127_301921_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.0000000000000000000000000000000000000000000000000000000000000000379 230.0
SHD2_k127_301921_3 Diguanylate cyclase K21084 - 2.7.7.65 0.000000000000000000000000000000000001235 155.0
SHD2_k127_301921_4 protein secretion K20276 - - 0.000000000594 62.0
SHD2_k127_3116038_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1322.0
SHD2_k127_3116038_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0 1264.0
SHD2_k127_3116038_10 - K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 289.0
SHD2_k127_3116038_11 Protein of unknown function (DUF3570) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004171 265.0
SHD2_k127_3116038_12 MarR family - - - 0.00000000000000000000000000000000000000000000000000006217 199.0
SHD2_k127_3116038_13 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000307 185.0
SHD2_k127_3116038_14 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000000000000000000000000000000000006241 175.0
SHD2_k127_3116038_15 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000002476 177.0
SHD2_k127_3116038_16 Fungal family of unknown function (DUF1776) - - - 0.0000000000000000000000000000000000000000000007658 177.0
SHD2_k127_3116038_17 Redoxin - - - 0.00000000000000000000000000000000000004944 149.0
SHD2_k127_3116038_18 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000008272 155.0
SHD2_k127_3116038_19 peptidyl-tyrosine sulfation K13992 - - 0.000000000000000000000000000000000006038 147.0
SHD2_k127_3116038_2 lysine biosynthetic process via aminoadipic acid - - - 6.661e-217 704.0
SHD2_k127_3116038_20 Divergent PAP2 family - - - 0.00000000000000000000000000000001681 131.0
SHD2_k127_3116038_21 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000001687 145.0
SHD2_k127_3116038_22 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000002722 140.0
SHD2_k127_3116038_23 - - - - 0.00000000000000000000000000000716 126.0
SHD2_k127_3116038_24 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000001703 125.0
SHD2_k127_3116038_25 Cold shock protein K03704 - - 0.000000000000000000000000002071 114.0
SHD2_k127_3116038_26 Domain of unknown function (DUF4266) - - - 0.0000000000000008348 86.0
SHD2_k127_3116038_27 cellulase activity - - - 0.00000000005177 76.0
SHD2_k127_3116038_28 - - - - 0.00000001294 64.0
SHD2_k127_3116038_29 TIR domain - - - 0.00000007718 62.0
SHD2_k127_3116038_3 L-asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 582.0
SHD2_k127_3116038_30 L-asparaginase K01424 - 3.5.1.1 0.000001333 49.0
SHD2_k127_3116038_4 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 441.0
SHD2_k127_3116038_5 GatB/GatE catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 454.0
SHD2_k127_3116038_6 tail specific protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 346.0
SHD2_k127_3116038_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 329.0
SHD2_k127_3116038_8 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 310.0
SHD2_k127_3116038_9 ApbE family K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 299.0
SHD2_k127_3117738_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 565.0
SHD2_k127_3117738_1 chlorophyll binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 479.0
SHD2_k127_3117738_2 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 325.0
SHD2_k127_3117738_3 TIGRFAM DNA binding domain protein, excisionase family K22491 - - 0.0000000000000000000004877 109.0
SHD2_k127_3117738_4 Outer membrane protein beta-barrel domain - - - 0.0002146 51.0
SHD2_k127_313327_0 PFAM OPT oligopeptide transporter protein - - - 1.393e-211 673.0
SHD2_k127_313327_1 extracellular matrix structural constituent - - - 0.000000000000001046 92.0
SHD2_k127_3145364_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 490.0
SHD2_k127_3145364_1 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000636 449.0
SHD2_k127_3145364_2 PFAM peptidase M1, membrane alanine aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004699 294.0
SHD2_k127_3145364_3 PAS domain - - - 0.00000000000000000000000000000000000000446 166.0
SHD2_k127_3145364_4 Belongs to the ompA family - - - 0.00000000000000000000775 101.0
SHD2_k127_3145364_5 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000006119 60.0
SHD2_k127_3175907_0 Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues K01791,K08068 GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008761,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576 3.2.1.183,5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 372.0
SHD2_k127_3175907_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 289.0
SHD2_k127_3175907_2 SpoIVB peptidase S55 K00973,K02414,K21449 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000006265 240.0
SHD2_k127_3190372_0 cAMP biosynthetic process K08884,K12132 - 2.7.11.1 7.31e-230 745.0
SHD2_k127_3190372_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 308.0
SHD2_k127_3209591_0 Ser Thr phosphatase family protein - - - 0.0 1054.0
SHD2_k127_3209591_1 PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K00256 - 1.3.99.16 6.854e-260 820.0
SHD2_k127_3209591_10 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000009549 117.0
SHD2_k127_3209591_11 Sigma-70, region 4 - - - 0.00000000005086 69.0
SHD2_k127_3209591_12 Protein of unknown function (DUF3494) - - - 0.0000000007418 74.0
SHD2_k127_3209591_2 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001737 273.0
SHD2_k127_3209591_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000001002 230.0
SHD2_k127_3209591_4 2Fe-2S -binding domain protein K18029 - 1.17.2.1 0.0000000000000000000000000000000000000000000000000000000000001542 222.0
SHD2_k127_3209591_5 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000000000000001137 204.0
SHD2_k127_3209591_6 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000003887 169.0
SHD2_k127_3209591_7 - - - - 0.00000000000000000000000000000000000000000007392 172.0
SHD2_k127_3209591_8 membrane - - - 0.000000000000000000000000000000000212 143.0
SHD2_k127_3209591_9 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000004969 131.0
SHD2_k127_3222327_0 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02372,K02535,K13599,K16363 GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 435.0
SHD2_k127_3222327_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 342.0
SHD2_k127_3222327_2 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001438 286.0
SHD2_k127_3228783_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 1.217e-317 996.0
SHD2_k127_3228783_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 1.408e-276 860.0
SHD2_k127_3228783_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 2.149e-199 636.0
SHD2_k127_3228783_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 326.0
SHD2_k127_3228783_4 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000002734 207.0
SHD2_k127_3228783_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone - - - 0.00000000000000000000000000000000000000158 150.0
SHD2_k127_3228783_6 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.00000000000000000000000000000004175 127.0
SHD2_k127_3247101_0 Domain of unknown function (DUF3520) K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 486.0
SHD2_k127_3247101_1 DEAD DEAH box helicase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 409.0
SHD2_k127_3247101_2 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.00000000000000000000000000000000000000000000000000000001826 205.0
SHD2_k127_3247101_3 Von Willebrand factor type A K07114 - - 0.0000000000000000000000000000000000001489 162.0
SHD2_k127_3247101_4 Acetyltransferase (GNAT) domain - - - 0.00000001177 66.0
SHD2_k127_3256763_0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 570.0
SHD2_k127_3256763_1 plastoquinone (Complex I) K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 526.0
SHD2_k127_3256763_2 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 314.0
SHD2_k127_3256763_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 302.0
SHD2_k127_3256763_4 Hydrogenase 4 membrane K12140 - - 0.000000000000000000000000000000000000000000000000009962 187.0
SHD2_k127_3256763_5 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.0000000000000000000000004098 109.0
SHD2_k127_3256763_6 cell wall binding repeat 2 - - - 0.0004732 49.0
SHD2_k127_3274051_0 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 409.0
SHD2_k127_3274051_1 Phosphoenolpyruvate carboxykinase K01610 GO:0000166,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004603 312.0
SHD2_k127_3274051_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000004173 250.0
SHD2_k127_3336472_0 chorismate binding enzyme K02552 - 5.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000006002 235.0
SHD2_k127_3336472_1 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.000000000000000000000000000000000000000000000000000000000005049 221.0
SHD2_k127_3336472_2 outer membrane efflux protein - - - 0.0003404 52.0
SHD2_k127_3340611_0 Heparinase II/III N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 316.0
SHD2_k127_3340611_1 SMART AAA ATPase K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009441 255.0
SHD2_k127_3340611_10 Capsular exopolysaccharide family - - - 0.00000000002362 76.0
SHD2_k127_3340611_11 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.00000000187 71.0
SHD2_k127_3340611_12 biosynthesis protein K19420 - - 0.0000005519 57.0
SHD2_k127_3340611_2 Sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002907 244.0
SHD2_k127_3340611_3 mannose-ethanolamine phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000003403 248.0
SHD2_k127_3340611_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000004074 243.0
SHD2_k127_3340611_5 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000000000000000000000000000008365 216.0
SHD2_k127_3340611_6 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.00000000000000000000000000000000288 145.0
SHD2_k127_3340611_7 -O-antigen K18814 - - 0.00000000000000000000000000006943 132.0
SHD2_k127_3340611_8 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000009838 129.0
SHD2_k127_3340611_9 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000002515 101.0
SHD2_k127_3351165_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005928 284.0
SHD2_k127_3351165_1 Sugar transferase, PEP-CTERM EpsH1 system associated - - - 0.00000000000000000000000000000000000000007329 169.0
SHD2_k127_3351165_2 G-rich domain on putative tyrosine kinase - - - 0.0000000000000000000000000000000000000001537 166.0
SHD2_k127_3351165_3 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000001115 158.0
SHD2_k127_3351165_4 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000001179 135.0
SHD2_k127_3351165_5 Glycosyl transferase - - - 0.000000002379 66.0
SHD2_k127_3351165_6 polysaccharide export K01991 - - 0.00002705 49.0
SHD2_k127_3359257_0 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 422.0
SHD2_k127_3359257_1 POT family K03305 - - 0.00000000000000000000000000000000000000000000000000000000001523 211.0
SHD2_k127_3359257_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000219 209.0
SHD2_k127_3360469_0 Tricorn protease PDZ domain K08676 - - 7.367e-264 832.0
SHD2_k127_3360469_1 RNA ligase activity K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 543.0
SHD2_k127_3371766_0 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 9.243e-233 729.0
SHD2_k127_3371766_1 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007528 433.0
SHD2_k127_3371766_2 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001686 293.0
SHD2_k127_3371766_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000008928 131.0
SHD2_k127_3371766_4 Domain of unknown function (DUF1844) - - - 0.000004602 56.0
SHD2_k127_337997_0 purine nucleobase transmembrane transporter activity K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007405 482.0
SHD2_k127_337997_1 IMG reference gene - - - 0.00000008065 66.0
SHD2_k127_337997_2 Domain of unknown function (DUF362) - - - 0.0000292 51.0
SHD2_k127_337997_3 Malate synthase K01638 - 2.3.3.9 0.0006574 46.0
SHD2_k127_3384726_0 Cys/Met metabolism PLP-dependent enzyme K01760,K01761 - 4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 524.0
SHD2_k127_3384726_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 385.0
SHD2_k127_3384726_2 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008826 294.0
SHD2_k127_3384726_3 Sodium/hydrogen exchanger family - - - 0.000000000000004616 76.0
SHD2_k127_3389026_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 614.0
SHD2_k127_3389026_1 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 349.0
SHD2_k127_3389026_2 PFAM OmpA MotB domain protein K03640 - - 0.00000005679 63.0
SHD2_k127_3400194_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 418.0
SHD2_k127_3400194_1 Peptidase M1 K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000009272 271.0
SHD2_k127_3400194_2 - - - - 0.0000000001961 72.0
SHD2_k127_3443630_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 461.0
SHD2_k127_3443630_1 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 294.0
SHD2_k127_3443630_2 NnrS protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000503 262.0
SHD2_k127_3443630_3 Transcriptional regulator - - - 0.000000000000000000000005375 107.0
SHD2_k127_3443630_4 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.00000000000000004247 90.0
SHD2_k127_3443630_6 pfam yhs - - - 0.0000000000003057 72.0
SHD2_k127_3446121_0 XFP C-terminal domain K01621 - 4.1.2.22,4.1.2.9 6.647e-198 617.0
SHD2_k127_3446121_1 COG COG1132 ABC-type multidrug transport system ATPase and permease components Defense mechanisms K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 411.0
SHD2_k127_3446121_2 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 402.0
SHD2_k127_3446121_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 335.0
SHD2_k127_3446121_4 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004999 299.0
SHD2_k127_3446121_5 Belongs to the peptidase S8 family K14645 - - 0.00000000000000000000000000000000000000000007144 177.0
SHD2_k127_3446121_6 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000005166 135.0
SHD2_k127_3446121_7 Phosphotransferase enzyme family - - - 0.000000000000000002433 98.0
SHD2_k127_3460503_0 cellulose binding K00505 - 1.14.18.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009031 396.0
SHD2_k127_3460503_1 LacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000572 301.0
SHD2_k127_3462959_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 462.0
SHD2_k127_3462959_1 Thymidylate synthase complementing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000671 415.0
SHD2_k127_3462959_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000001886 202.0
SHD2_k127_3462959_3 RibD C-terminal domain K00082 - 1.1.1.193 0.000007562 48.0
SHD2_k127_3471277_0 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 1.958e-230 731.0
SHD2_k127_3471277_1 cellular manganese ion homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006739 349.0
SHD2_k127_3471277_2 Superoxide dismutase K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 290.0
SHD2_k127_3471277_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005613 285.0
SHD2_k127_3471277_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000006282 233.0
SHD2_k127_3471277_5 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000001072 243.0
SHD2_k127_3471277_6 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000002877 187.0
SHD2_k127_3471277_7 Protein involved in outer membrane biogenesis K07289,K09800 - - 0.00000000000000000000000000000000000000000004278 185.0
SHD2_k127_3471277_8 extracellular matrix structural constituent - - - 0.000000001069 72.0
SHD2_k127_3471277_9 Oxidoreductase family, NAD-binding Rossmann fold K00118,K13020 - 1.1.1.335,1.1.99.28 0.0000001517 58.0
SHD2_k127_3503482_0 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 305.0
SHD2_k127_3503482_1 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000181 229.0
SHD2_k127_3503482_10 - - - - 0.00005236 53.0
SHD2_k127_3503482_2 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000003615 235.0
SHD2_k127_3503482_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000002288 230.0
SHD2_k127_3503482_4 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000004744 211.0
SHD2_k127_3503482_5 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000000000114 207.0
SHD2_k127_3503482_6 - - - - 0.00000000000000000000000000000000000000000000000003317 188.0
SHD2_k127_3503482_7 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.00000000000000000000000001412 113.0
SHD2_k127_3503482_8 Vitamin B12 dependent methionine synthase, activation domain - - - 0.000000000000000939 86.0
SHD2_k127_3503482_9 Outer membrane protein beta-barrel domain - - - 0.000004961 57.0
SHD2_k127_3510273_0 transferase activity, transferring amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004633 330.0
SHD2_k127_3510273_1 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 332.0
SHD2_k127_3510273_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000003618 229.0
SHD2_k127_3510273_3 Acetyltransferase (GNAT) family - - - 0.0004732 49.0
SHD2_k127_3516744_0 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001576 282.0
SHD2_k127_3516744_1 TGS domain K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001592 271.0
SHD2_k127_3516744_2 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000002101 239.0
SHD2_k127_3529074_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 598.0
SHD2_k127_3529074_1 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000001135 88.0
SHD2_k127_3529074_2 COG0457 FOG TPR repeat - - - 0.0001622 52.0
SHD2_k127_3532043_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000000000000003868 255.0
SHD2_k127_3532043_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000008014 251.0
SHD2_k127_3532043_2 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000003764 200.0
SHD2_k127_3532043_3 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.0000000000000000000000000000001005 138.0
SHD2_k127_3532043_5 Subtilase family - - - 0.0000000000000004378 89.0
SHD2_k127_3532043_6 S4 RNA-binding domain - GO:0008150,GO:0040007 - 0.00000004759 63.0
SHD2_k127_3572926_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002841 292.0
SHD2_k127_3572926_1 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002168 276.0
SHD2_k127_3572926_2 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000005051 198.0
SHD2_k127_3572926_3 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000002952 189.0
SHD2_k127_3572926_4 - - - - 0.0000000000000002027 86.0
SHD2_k127_3588139_0 Putative modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 356.0
SHD2_k127_3588139_1 COG1653 ABC-type sugar transport system, periplasmic component - - - 0.000000000003786 79.0
SHD2_k127_3591093_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007807 262.0
SHD2_k127_3591093_1 Glycosyl transferase - - - 0.0000000000000000000003238 109.0
SHD2_k127_3591093_2 Glycosyltransferase Family 4 - - - 0.0000000002838 66.0
SHD2_k127_359589_0 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000524 212.0
SHD2_k127_359589_1 - - - - 0.00000000000000000000000000000000000000000000007884 181.0
SHD2_k127_359589_2 Nitrous oxide-stimulated promoter - - - 0.000000000000000000000000000000002808 139.0
SHD2_k127_359589_3 YCII-related domain - - - 0.0000000000000000000000002799 109.0
SHD2_k127_359589_4 - - - - 0.0000000000000000004713 88.0
SHD2_k127_3608334_0 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 325.0
SHD2_k127_3608334_1 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 318.0
SHD2_k127_3608334_2 PFAM biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.00000000000000000000000000000000332 143.0
SHD2_k127_3608334_3 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000001575 83.0
SHD2_k127_3633660_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008596 438.0
SHD2_k127_3633660_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 303.0
SHD2_k127_3633660_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000001368 199.0
SHD2_k127_364138_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 356.0
SHD2_k127_364138_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 296.0
SHD2_k127_364138_2 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000000000000004682 212.0
SHD2_k127_364138_3 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000001284 154.0
SHD2_k127_364138_4 - - - - 0.0000000000000000000000000000000000162 143.0
SHD2_k127_3666979_0 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000002314 216.0
SHD2_k127_3666979_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000007611 154.0
SHD2_k127_3666979_2 AAA domain - - - 0.0000000000000000501 96.0
SHD2_k127_3666979_3 Major facilitator superfamily - - - 0.0000000002199 63.0
SHD2_k127_3676728_0 PFAM Glycosyl transferase, group 1 - - - 2.442e-304 952.0
SHD2_k127_3676728_1 PFAM glycosidase PH1107-related K18785,K20885 - 2.4.1.319,2.4.1.320,2.4.1.339,2.4.1.340 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004436 445.0
SHD2_k127_3676728_2 Zinc metalloprotease (Elastase) K20274 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 392.0
SHD2_k127_3676728_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 328.0
SHD2_k127_3676728_4 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000008957 207.0
SHD2_k127_3676728_5 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000004461 176.0
SHD2_k127_3676728_6 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000004913 176.0
SHD2_k127_3676728_7 Lipid A Biosynthesis N-terminal domain - - - 0.00000000000000000000000000002667 123.0
SHD2_k127_3684428_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004803 273.0
SHD2_k127_3684428_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001311 244.0
SHD2_k127_3684428_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000008684 123.0
SHD2_k127_3699794_0 Peptidase family M1 domain K01992 - - 0.0 1183.0
SHD2_k127_3699794_1 arsenical-resistance protein K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 536.0
SHD2_k127_3699794_2 (ABC) transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 378.0
SHD2_k127_3699794_3 major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 355.0
SHD2_k127_3699794_4 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000002415 96.0
SHD2_k127_3699794_5 PEP-CTERM motif - - - 0.000000000000001077 91.0
SHD2_k127_3717173_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002467 282.0
SHD2_k127_3717173_1 - - - - 0.00000000000000000000000000000000000000003404 167.0
SHD2_k127_3717173_2 Tetratricopeptide repeat - - - 0.0000000000000001179 88.0
SHD2_k127_3717173_3 Prokaryotic N-terminal methylation motif K02456,K02650 - - 0.0000000000001066 81.0
SHD2_k127_3717173_4 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07713,K07714,K19641 - - 0.00000001723 58.0
SHD2_k127_3717173_5 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000001494 62.0
SHD2_k127_3727311_0 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 519.0
SHD2_k127_3727311_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 462.0
SHD2_k127_3727311_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 435.0
SHD2_k127_3727311_3 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 400.0
SHD2_k127_3727311_4 Secretion protein K01993 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 346.0
SHD2_k127_3727311_5 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 334.0
SHD2_k127_3727311_6 Tryptophan-rich sensory protein K05770 - - 0.0000000000000000000000000000000000001104 147.0
SHD2_k127_3727311_7 efflux transmembrane transporter activity K12340,K15725 - - 0.00000005367 63.0
SHD2_k127_37610_0 Seven times multi-haem cytochrome CxxCH K10535 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114 1.7.2.6 2.57e-196 620.0
SHD2_k127_37610_1 all-trans-retinol 13,14-reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 497.0
SHD2_k127_37610_2 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 340.0
SHD2_k127_37610_3 PFAM Ornithine cyclodeaminase mu-crystallin K01750,K19244 - 1.4.1.1,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 321.0
SHD2_k127_37610_4 peptidase activity, acting on L-amino acid peptides K01448,K07260,K09955,K13276 GO:0005575,GO:0005576 3.4.17.14,3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000006081 287.0
SHD2_k127_37610_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000378 248.0
SHD2_k127_37610_6 Histidine kinase - - - 0.000000000000000000000000000000000000000002334 173.0
SHD2_k127_37610_7 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000003866 124.0
SHD2_k127_37610_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000004835 113.0
SHD2_k127_37610_9 peroxiredoxin activity - - - 0.00000000000000289 85.0
SHD2_k127_3769266_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001245 283.0
SHD2_k127_3769266_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000004163 256.0
SHD2_k127_3769266_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000004447 213.0
SHD2_k127_3769266_3 serine-type endopeptidase activity - - - 0.00000000000000000000000000000002141 139.0
SHD2_k127_3769266_4 Belongs to the peptidase S8 family - - - 0.000000000002673 79.0
SHD2_k127_3769266_5 domain protein K20276 - - 0.000002971 60.0
SHD2_k127_3769266_6 - - - - 0.0005507 48.0
SHD2_k127_3769266_7 domain protein K20276 - - 0.0007581 53.0
SHD2_k127_3807047_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 629.0
SHD2_k127_3807047_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000734 398.0
SHD2_k127_3817383_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009709 480.0
SHD2_k127_3817383_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005406 466.0
SHD2_k127_3817383_2 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 403.0
SHD2_k127_3817383_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009701 368.0
SHD2_k127_3817383_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002246 272.0
SHD2_k127_3829676_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 406.0
SHD2_k127_3829676_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 351.0
SHD2_k127_3829676_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 302.0
SHD2_k127_3829676_3 YmdB-like protein K02029,K02030,K09769 GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 290.0
SHD2_k127_3829676_4 isoprenoid biosynthetic process K00795,K02523,K13789 GO:0003674,GO:0003824,GO:0004161,GO:0004311,GO:0004337,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033383,GO:0033384,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045337,GO:0045338,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000001674 252.0
SHD2_k127_3829676_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000003698 166.0
SHD2_k127_3829676_6 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000007464 88.0
SHD2_k127_3829676_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000004773 76.0
SHD2_k127_3848678_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 439.0
SHD2_k127_3848678_1 Hydrogenase accessory protein HypB K04652 - - 0.000000000000000000000000000000000000000000000000000000000008966 222.0
SHD2_k127_3848678_2 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000000000000000000000000000001479 207.0
SHD2_k127_3848678_3 nickel cation binding K04651 - - 0.0000000000000000002311 92.0
SHD2_k127_3852588_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 389.0
SHD2_k127_3852588_1 Bacterial sugar transferase K03606 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005422 341.0
SHD2_k127_3852588_2 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001526 256.0
SHD2_k127_3852588_3 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000001179 165.0
SHD2_k127_3852588_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.000000000000000000000001425 114.0
SHD2_k127_3852588_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000007095 71.0
SHD2_k127_3852636_0 response regulator K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 445.0
SHD2_k127_3852636_1 Histidine kinase K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000001888 209.0
SHD2_k127_3852636_2 - - - - 0.000455 49.0
SHD2_k127_385400_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.312e-277 863.0
SHD2_k127_385400_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 316.0
SHD2_k127_3856184_0 glutamate dehydrogenase [NAD(P)+] activity K00260,K00261,K00262 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 1.281e-221 693.0
SHD2_k127_3856184_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 471.0
SHD2_k127_3856184_2 FAD binding domain K00103,K00279 - 1.1.3.8,1.5.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 325.0
SHD2_k127_3856184_3 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002411 279.0
SHD2_k127_3856184_4 Xanthine and CO dehydrogenases maturation factor XdhC CoxF family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000008107 228.0
SHD2_k127_3856184_5 methyltransferase - - - 0.00000000000000000000000000000000000000000002173 169.0
SHD2_k127_3856184_7 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000003653 84.0
SHD2_k127_3876581_0 Domain of Unknown Function (DUF1259) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 329.0
SHD2_k127_3876581_1 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 321.0
SHD2_k127_3876581_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000002529 203.0
SHD2_k127_3876581_3 Glucose-methanol-choline oxidoreductase K00108 - 1.1.99.1 0.0000000006944 63.0
SHD2_k127_3876581_4 Chorismate mutase type II - - - 0.00003488 53.0
SHD2_k127_3878430_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000003659 138.0
SHD2_k127_3879240_0 PFAM ATP-binding region, ATPase domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007945 314.0
SHD2_k127_3879240_1 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000002091 223.0
SHD2_k127_3879240_2 Putative porin - - - 0.0000000000000000000000000000000000001499 157.0
SHD2_k127_3907885_0 transferase activity, transferring glycosyl groups K00694,K00786 - 2.4.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 497.0
SHD2_k127_3907885_1 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 306.0
SHD2_k127_3907885_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000002007 169.0
SHD2_k127_3907885_3 TIGRFAM molybdenum cofactor synthesis - - - 0.0000000000000000000000000000000000000002937 163.0
SHD2_k127_3907885_4 Glycosyltransferase family 87 - - - 0.0000000000000000000000000000000000001468 156.0
SHD2_k127_3911248_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 445.0
SHD2_k127_3911248_1 belongs to the iron- containing alcohol dehydrogenase family K04072 - 1.1.1.1,1.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 422.0
SHD2_k127_3911248_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 392.0
SHD2_k127_3911248_3 Domain of unknown function (DUF4912) K02040 - - 0.00000000000000000000000000000000000000000000000000008952 203.0
SHD2_k127_3911248_4 Protein of unknown function (DUF3175) - - - 0.000000000000000000000000000000001949 133.0
SHD2_k127_3911248_5 Surface antigen - - - 0.00000000000000002986 85.0
SHD2_k127_3911248_6 Peptidase M56 - - - 0.0000000000006549 78.0
SHD2_k127_3916601_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 373.0
SHD2_k127_3916601_1 transferase activity, transferring alkyl or aryl (other than methyl) groups K00806,K14215,K21273 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001777 273.0
SHD2_k127_3916601_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000004948 240.0
SHD2_k127_3916601_3 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000002535 219.0
SHD2_k127_3916601_4 phosphatidate cytidylyltransferase activity K00981 - 2.7.7.41 0.000000000000000000000000000000000000000002664 171.0
SHD2_k127_3919534_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 552.0
SHD2_k127_3919534_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903,K14067 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009361,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0042709,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494 6.2.1.5,6.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 428.0
SHD2_k127_3919534_10 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000008999 92.0
SHD2_k127_3919534_11 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000001132 96.0
SHD2_k127_3919534_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 399.0
SHD2_k127_3919534_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 383.0
SHD2_k127_3919534_4 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 331.0
SHD2_k127_3919534_5 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 291.0
SHD2_k127_3919534_6 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 295.0
SHD2_k127_3919534_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000009379 262.0
SHD2_k127_3919534_8 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000002652 158.0
SHD2_k127_3919534_9 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000587 103.0
SHD2_k127_3938670_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 2.582e-217 704.0
SHD2_k127_3938670_1 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 510.0
SHD2_k127_3938670_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 406.0
SHD2_k127_3938670_3 phosphoglucosamine mutase activity K01835,K01840,K15778 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000965 366.0
SHD2_k127_3938670_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K03574 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.6.1.55 0.0000000000000000000000000000000000000000004698 168.0
SHD2_k127_3938670_5 outer membrane assembly lipoprotein YfiO K05807 - - 0.0000000000000000000000002465 121.0
SHD2_k127_3938670_6 dephospho-CoA kinase K00859 GO:0003674,GO:0003824,GO:0004140,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005777,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009507,GO:0009536,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000002461 86.0
SHD2_k127_3938670_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - 0.00000000002783 76.0
SHD2_k127_395231_0 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.132e-318 989.0
SHD2_k127_395231_1 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 425.0
SHD2_k127_395231_2 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 312.0
SHD2_k127_395231_3 Methyl-viologen-reducing hydrogenase, delta subunit K14127,K14128 - 1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000009675 218.0
SHD2_k127_395231_4 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000005189 185.0
SHD2_k127_395231_5 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.000000001332 70.0
SHD2_k127_3969986_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 2.614e-284 889.0
SHD2_k127_3969986_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 5.384e-217 686.0
SHD2_k127_3969986_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000003356 215.0
SHD2_k127_3969986_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000004274 199.0
SHD2_k127_3969986_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00002856 46.0
SHD2_k127_3973416_0 nodulation K00612 - - 2.819e-213 672.0
SHD2_k127_3973416_1 SIS domain K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 443.0
SHD2_k127_3973416_2 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008569 408.0
SHD2_k127_3973416_3 Polynucleotide kinase 3 phosphatase - - - 0.00000000000000000000000000000000000000000000000003447 205.0
SHD2_k127_3975043_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000002661 174.0
SHD2_k127_3975043_1 - - - - 0.000000000000000000000000004857 112.0
SHD2_k127_3975043_2 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000009203 115.0
SHD2_k127_3984617_0 PKD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 440.0
SHD2_k127_3984617_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000001444 280.0
SHD2_k127_3984617_2 - K01278,K03561 - 3.4.14.5 0.000000000000000000000000000000000000002768 170.0
SHD2_k127_3984617_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000004143 83.0
SHD2_k127_3984617_4 Belongs to the peptidase S8 family K01361,K20276 - 3.4.21.96 0.000000000000002811 91.0
SHD2_k127_3990822_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 319.0
SHD2_k127_3990822_1 PFAM molybdopterin biosynthesis MoaE protein K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000000009102 139.0
SHD2_k127_3990822_2 HIT domain K19710 - 2.7.7.53 0.00000000000000000000000000000002714 134.0
SHD2_k127_3990822_3 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K10697 - - 0.000000000000000000000000007299 116.0
SHD2_k127_3990822_4 Single cache domain 3 K07709 - 2.7.13.3 0.00000000000000000000000001602 118.0
SHD2_k127_3990822_5 Mo-molybdopterin cofactor metabolic process K03636,K21142 - 2.8.1.12 0.00000000000002922 79.0
SHD2_k127_4017477_0 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008646 330.0
SHD2_k127_4017477_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001792 236.0
SHD2_k127_4017477_10 - - - - 0.00000000000007818 85.0
SHD2_k127_4017477_2 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000001142 237.0
SHD2_k127_4017477_3 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000006243 230.0
SHD2_k127_4017477_4 - - - - 0.00000000000000000000000000000000000000000000000000000000001059 213.0
SHD2_k127_4017477_5 DNA methylase K00571 - 2.1.1.72 0.00000000000000000000000000000000008283 134.0
SHD2_k127_4017477_6 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000003213 132.0
SHD2_k127_4017477_7 - - - - 0.00000000000000000000000000001646 121.0
SHD2_k127_4017477_8 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.000000000000000000002299 96.0
SHD2_k127_4017477_9 Regulatory protein ArsR - - - 0.0000000000000005161 83.0
SHD2_k127_4032709_0 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000009459 163.0
SHD2_k127_4032709_1 Transmembrane and TPR repeat-containing protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827 - 0.000000000000000005941 96.0
SHD2_k127_4039257_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000002091 201.0
SHD2_k127_4039257_1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000002873 95.0
SHD2_k127_4039257_2 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000003215 65.0
SHD2_k127_404574_0 argininosuccinate synthase K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 490.0
SHD2_k127_404574_1 acetylornithine aminotransferase K00821,K00840 - 2.6.1.11,2.6.1.17,2.6.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 326.0
SHD2_k127_404574_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000004641 263.0
SHD2_k127_404574_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000504 178.0
SHD2_k127_404574_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000003694 108.0
SHD2_k127_4075940_0 Propeptide_C25 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006866 456.0
SHD2_k127_4075940_1 Two component regulator propeller - - - 0.000000000000000000000000000000007206 139.0
SHD2_k127_4075940_2 Trm112p-like protein K00912,K09791 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 0.000000000000000000503 89.0
SHD2_k127_4088236_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 378.0
SHD2_k127_4088236_1 PFAM Ribonuclease BN-like family K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 323.0
SHD2_k127_4088236_2 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001171 288.0
SHD2_k127_4088236_3 Domain of unknown function (DUF305) - - - 0.0000000000000000000001962 104.0
SHD2_k127_4088236_4 Glycosyl transferase 4-like - - - 0.00001602 51.0
SHD2_k127_4114454_0 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005207 389.0
SHD2_k127_4114454_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008579 332.0
SHD2_k127_4114454_2 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000003943 229.0
SHD2_k127_4114454_3 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000002035 168.0
SHD2_k127_4184184_0 Glycosyl transferases group 1 K00754 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004988 381.0
SHD2_k127_4184184_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001618 255.0
SHD2_k127_4184184_2 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.000000000000000000000000000000000000000000005629 174.0
SHD2_k127_4212255_0 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 371.0
SHD2_k127_4212255_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000002346 267.0
SHD2_k127_4212255_2 synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000000000000000008236 242.0
SHD2_k127_4212255_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000001995 111.0
SHD2_k127_4212255_4 cellulose binding - - - 0.00000000008269 74.0
SHD2_k127_4224222_0 uridine kinase K00876 - 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 548.0
SHD2_k127_4224222_1 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 506.0
SHD2_k127_4224222_2 beta-1,4-mannooligosaccharide phosphorylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 489.0
SHD2_k127_4224222_3 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 328.0
SHD2_k127_4224222_4 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000002974 213.0
SHD2_k127_4224222_5 LemA family K03744 - - 0.0000000000000000000000000000000000000000000002571 174.0
SHD2_k127_4224222_6 NUDIX domain - - - 0.0000000000000000000000000000000000000004924 156.0
SHD2_k127_4224222_7 Belongs to the glycosyl hydrolase 30 family K15924 - 3.2.1.136 0.00000000000004175 84.0
SHD2_k127_4224222_8 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07658 - - 0.0000007591 61.0
SHD2_k127_4224222_9 PFAM ATP-binding region ATPase domain protein - - - 0.000001693 61.0
SHD2_k127_4226742_0 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 6.593e-207 661.0
SHD2_k127_4226742_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 482.0
SHD2_k127_4226742_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000004536 123.0
SHD2_k127_4226742_3 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000004216 119.0
SHD2_k127_4226742_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000006362 105.0
SHD2_k127_4242627_0 class II (D K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 592.0
SHD2_k127_4242627_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000006284 251.0
SHD2_k127_4242627_10 Domain of unknown function (DUF4388) - - - 0.0002586 53.0
SHD2_k127_4242627_2 MotA/TolQ/ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000000000000000000000002709 205.0
SHD2_k127_4242627_3 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000005981 174.0
SHD2_k127_4242627_4 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000004471 171.0
SHD2_k127_4242627_5 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.00000000000000000000000000000002191 141.0
SHD2_k127_4242627_6 PFAM outer membrane efflux protein K12340 - - 0.0000000000000000000000001135 122.0
SHD2_k127_4242627_7 biopolymer transport protein K03559 - - 0.0000000000000000008072 93.0
SHD2_k127_4242627_8 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.0000000000103 71.0
SHD2_k127_4242627_9 Tetratricopeptide repeat - - - 0.00000003004 67.0
SHD2_k127_4251623_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 3.483e-236 740.0
SHD2_k127_4251623_1 PFAM Carbamoyl-phosphate synthase L chain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 558.0
SHD2_k127_4251623_10 PFAM Mo-dependent nitrogenase - - - 0.000000000000002931 79.0
SHD2_k127_4251623_11 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 0.000000000001537 75.0
SHD2_k127_4251623_12 M6 family metalloprotease domain protein - - - 0.000004393 57.0
SHD2_k127_4251623_2 PFAM Thiolase K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 436.0
SHD2_k127_4251623_3 Belongs to the UPF0219 family K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 427.0
SHD2_k127_4251623_4 helicase involved in DNA repair and perhaps also replication K02342,K03722 - 2.7.7.7,3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 346.0
SHD2_k127_4251623_5 - - - - 0.00000000000000000000000000000000000000000000000000000005487 204.0
SHD2_k127_4251623_6 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000001499 144.0
SHD2_k127_4251623_7 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000007078 133.0
SHD2_k127_4251623_8 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000000000002716 113.0
SHD2_k127_4251623_9 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000002266 81.0
SHD2_k127_4255667_0 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 553.0
SHD2_k127_4255667_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 486.0
SHD2_k127_4255667_2 Leucyl aminopeptidase (Aminopeptidase T) K19689 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 470.0
SHD2_k127_4255667_3 ATPase activity K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 296.0
SHD2_k127_4255667_4 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000002957 240.0
SHD2_k127_4255667_5 deoxyhypusine monooxygenase activity K01256 - 3.4.11.2 0.00000000000000000000000000000000000000001925 164.0
SHD2_k127_4255667_6 tRNA synthetase subunit beta - - - 0.000000000000000000000000000000004927 138.0
SHD2_k127_4255667_7 - - - - 0.00000002246 66.0
SHD2_k127_4256560_0 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 336.0
SHD2_k127_4256560_1 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 341.0
SHD2_k127_4256560_2 RNA pseudouridylate synthase K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000003211 212.0
SHD2_k127_4256560_3 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000001076 196.0
SHD2_k127_4256560_4 Histidine kinase K13040 - 2.7.13.3 0.00000000000000000000000000000000000001672 166.0
SHD2_k127_4256560_5 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.00000000000000000000000000000000000002546 149.0
SHD2_k127_4256560_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000004982 132.0
SHD2_k127_4256560_7 - - - - 0.0000002121 63.0
SHD2_k127_4256560_8 Right handed beta helix region - - - 0.00002636 57.0
SHD2_k127_4268404_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 612.0
SHD2_k127_4268404_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 399.0
SHD2_k127_4270305_0 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005235 325.0
SHD2_k127_4270305_1 Domains REC, sigma54 interaction, HTH8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001232 243.0
SHD2_k127_4270305_2 Histidine kinase HAMP - - - 0.00000000000000000000000000000000000000000000000000000000000000000002834 251.0
SHD2_k127_4270305_3 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000000000000000001137 211.0
SHD2_k127_4270305_4 - - - - 0.00000000000000000000000000000000000000000000002457 177.0
SHD2_k127_4270305_5 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000000000000000000000003088 173.0
SHD2_k127_4270305_6 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000001224 183.0
SHD2_k127_4270305_7 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000001986 99.0
SHD2_k127_4270305_8 HEAT repeats - - - 0.000000000000003959 87.0
SHD2_k127_4277653_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 473.0
SHD2_k127_4277653_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002124 291.0
SHD2_k127_4277653_2 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000779 228.0
SHD2_k127_4278916_0 Fungal trichothecene efflux pump (TRI12) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 500.0
SHD2_k127_4278916_1 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002562 254.0
SHD2_k127_4278916_2 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000027 251.0
SHD2_k127_4287029_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 547.0
SHD2_k127_4287029_1 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 350.0
SHD2_k127_4287029_2 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000004291 158.0
SHD2_k127_4287029_3 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.000000000000000000000000001725 114.0
SHD2_k127_4287029_4 cellulose binding - - - 0.0000000000001846 83.0
SHD2_k127_4288037_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 391.0
SHD2_k127_4288037_1 Ornithine cyclodeaminase/mu-crystallin family K01750,K18258,K19244 - 1.4.1.1,1.5.1.25,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 376.0
SHD2_k127_4288037_10 SnoaL-like domain - - - 0.0000000000000000000000000000000001517 138.0
SHD2_k127_4288037_11 PFAM PAS fold - - - 0.0000000000000000000000000000004659 126.0
SHD2_k127_4288037_12 SnoaL-like polyketide cyclase - - - 0.00000000000000000000104 106.0
SHD2_k127_4288037_13 Phosphotransferase enzyme family K17880 - 2.7.1.119 0.00000000002564 69.0
SHD2_k127_4288037_14 - - - - 0.00005027 53.0
SHD2_k127_4288037_2 AdoMet dependent proline di-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005385 267.0
SHD2_k127_4288037_3 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000000000000000000000000000000000000000000000000000000000000000099 253.0
SHD2_k127_4288037_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003095 250.0
SHD2_k127_4288037_5 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000007562 161.0
SHD2_k127_4288037_6 GrpB protein - - - 0.0000000000000000000000000000000000000002459 162.0
SHD2_k127_4288037_7 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000000000000000007428 155.0
SHD2_k127_4288037_8 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000003466 149.0
SHD2_k127_4288037_9 - - - - 0.00000000000000000000000000000000003519 136.0
SHD2_k127_4346734_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 8.002e-279 880.0
SHD2_k127_4346734_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 4.765e-227 710.0
SHD2_k127_4346734_10 PFAM Membrane protein of K08972 - - 0.000000000000000000005283 98.0
SHD2_k127_4346734_11 Putative zinc ribbon domain - - - 0.0000000000000000008978 89.0
SHD2_k127_4346734_12 - - - - 0.000000000005588 79.0
SHD2_k127_4346734_13 energy transducer activity K03832 - - 0.00000000001187 74.0
SHD2_k127_4346734_2 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 395.0
SHD2_k127_4346734_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 304.0
SHD2_k127_4346734_4 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009408 298.0
SHD2_k127_4346734_5 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.000000000000000000000000000000000000000000000000000000007678 202.0
SHD2_k127_4346734_6 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.00000000000000000000000000000000000004779 148.0
SHD2_k127_4346734_8 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000001169 112.0
SHD2_k127_4346734_9 Sigma-70 region 2 - - - 0.0000000000000000000003443 107.0
SHD2_k127_4364731_0 TOBE domain K02017,K02018 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000005361 269.0
SHD2_k127_4364731_1 Binding-protein-dependent transport system inner membrane component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001397 257.0
SHD2_k127_4364731_2 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000452 248.0
SHD2_k127_4364731_3 Molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.00000000000000000000000000000000000000000001726 177.0
SHD2_k127_4364731_4 TOBE domain - - - 0.0000000001237 68.0
SHD2_k127_4383049_0 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004878 486.0
SHD2_k127_4383049_1 Uncharacterized protein conserved in bacteria (DUF2344) - - - 0.0000000000000000000000000000000000000000007026 177.0
SHD2_k127_4383552_0 Acyl-CoA synthetase (NDP forming) K09181 - - 2.08e-314 985.0
SHD2_k127_4383552_1 ATP hydrolysis coupled proton transport - - - 0.000000000000000000000000000003378 135.0
SHD2_k127_4385035_0 Elongator protein 3, MiaB family, Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 358.0
SHD2_k127_4385035_1 AMMECR1 K06990,K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007348 262.0
SHD2_k127_4385035_2 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000794 259.0
SHD2_k127_4385035_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.000000000000000000000000000000000000000005867 177.0
SHD2_k127_4393597_0 GDP-mannose mannosyl hydrolase activity K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000008929 167.0
SHD2_k127_4393597_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000002942 136.0
SHD2_k127_4393597_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000001973 125.0
SHD2_k127_4393597_3 Cupin 2 conserved barrel domain protein - - - 0.00000003849 64.0
SHD2_k127_4393597_4 Cupin domain - - - 0.000000172 61.0
SHD2_k127_4393597_5 TIGRFAM RHS repeat-associated core domain - - - 0.0006203 52.0
SHD2_k127_4403927_0 PFAM Glycosyl transferases group 1 K12995 - 2.4.1.348 0.000000000000000000000000000000000000000000004806 182.0
SHD2_k127_4403927_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000009578 143.0
SHD2_k127_4403927_2 Bacterial capsule synthesis protein K07282 - - 0.000000000000000000000001906 117.0
SHD2_k127_4403927_3 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000001719 77.0
SHD2_k127_4416662_0 helicase superfamily c-terminal domain K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 531.0
SHD2_k127_4416662_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 319.0
SHD2_k127_4416662_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000003553 253.0
SHD2_k127_4416662_3 Protein of unknown function (DUF1572) - - - 0.00000000000000000000000000000000000000000000001795 178.0
SHD2_k127_4416662_4 Cytochrome C biogenesis K02200 - - 0.0000006031 62.0
SHD2_k127_4425640_0 PFAM SpoVR like protein K06415 - - 6.843e-206 652.0
SHD2_k127_4425640_1 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 333.0
SHD2_k127_4425640_2 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000001861 145.0
SHD2_k127_4425640_3 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000004514 97.0
SHD2_k127_4425640_4 - - - - 0.000000000000001494 91.0
SHD2_k127_4461114_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 541.0
SHD2_k127_4461114_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 377.0
SHD2_k127_4461114_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000001509 92.0
SHD2_k127_4470520_0 protein kinase activity K07180 GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.0 1022.0
SHD2_k127_4470520_1 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 436.0
SHD2_k127_4470520_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 384.0
SHD2_k127_4509801_0 Domain of unknown function (DUF1998) K06877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 616.0
SHD2_k127_4509801_1 RNase_H superfamily K07502 - - 0.000000000000000000000000000003117 130.0
SHD2_k127_4524462_0 serine-type peptidase activity K08676 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.0 1109.0
SHD2_k127_4524462_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 3.517e-319 992.0
SHD2_k127_4524462_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 352.0
SHD2_k127_4524462_3 WD40-like Beta Propeller Repeat - - - 0.00004187 55.0
SHD2_k127_4530969_0 PFAM Mg2 transporter protein CorA family protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 336.0
SHD2_k127_4530969_1 Domain of unknown function (DUF1732) K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000004109 245.0
SHD2_k127_4530969_2 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000003317 185.0
SHD2_k127_4530969_3 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000003537 160.0
SHD2_k127_4530969_4 Domain of unknown function (DUF814) - - - 0.00000000000000000000000000000002972 145.0
SHD2_k127_4530969_5 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000002728 108.0
SHD2_k127_4530969_6 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000002288 78.0
SHD2_k127_4546736_0 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 1.427e-222 711.0
SHD2_k127_4546736_1 PFAM CobQ CobB MinD ParA nucleotide binding domain K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 332.0
SHD2_k127_4546736_10 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000003494 99.0
SHD2_k127_4546736_11 PFAM SMP-30 Gluconolaconase - - - 0.000000002646 68.0
SHD2_k127_4546736_2 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 321.0
SHD2_k127_4546736_3 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000001829 230.0
SHD2_k127_4546736_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000625 217.0
SHD2_k127_4546736_5 SurA N-terminal domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000002218 202.0
SHD2_k127_4546736_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000003327 149.0
SHD2_k127_4546736_7 - - - - 0.00000000000000000000000000000000003142 145.0
SHD2_k127_4546736_8 Histidine kinase K07679,K07716 - 2.7.13.3 0.00000000000000000000000000000007692 139.0
SHD2_k127_4546736_9 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000003057 103.0
SHD2_k127_4560668_0 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007506 249.0
SHD2_k127_4560668_1 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.00000000000000000000000000000000000000000000000000000001802 211.0
SHD2_k127_4560668_2 PFAM NAD-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000002134 182.0
SHD2_k127_4560668_3 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000003712 77.0
SHD2_k127_4622141_0 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 329.0
SHD2_k127_4622141_1 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004878 254.0
SHD2_k127_4622141_2 Domain of unknown function (DUF374) K09778 - - 0.000000000000000000000000000000000000000000007419 175.0
SHD2_k127_4622141_3 PFAM Three-deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000002597 119.0
SHD2_k127_4685746_0 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 287.0
SHD2_k127_4685746_1 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.00000000000000000000000000004519 124.0
SHD2_k127_4685746_2 Peptidase M36 - - - 0.00000000000000000009411 102.0
SHD2_k127_4691289_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008647 340.0
SHD2_k127_4691289_1 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002695 280.0
SHD2_k127_4691289_2 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000001594 214.0
SHD2_k127_4691289_3 PFAM response regulator receiver K02483,K07658,K07668 - - 0.0000000000000000000000002949 107.0
SHD2_k127_4691289_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000007086 66.0
SHD2_k127_4691289_5 - - - - 0.00005682 53.0
SHD2_k127_4691289_6 - - - - 0.0001967 53.0
SHD2_k127_470253_0 LytB protein K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 431.0
SHD2_k127_470253_1 Catalyzes the reversible hydration of fumarate to (S)- malate K01676,K03780 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 320.0
SHD2_k127_470253_2 Catalyzes the reversible hydration of fumarate to (S)- malate K01676,K03780 - 4.2.1.2,4.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000002475 231.0
SHD2_k127_4711772_0 Cellulose biosynthesis protein BcsQ K04562 - - 0.000000000000000000000000000000000001698 151.0
SHD2_k127_4711772_1 CheY-like receiver AAA-type ATPase and DNA-binding domains K11384 - - 0.0000000261 64.0
SHD2_k127_4711772_2 Sigma-54 interaction domain K10943 - - 0.00001041 48.0
SHD2_k127_4723121_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 458.0
SHD2_k127_4723121_1 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007792 350.0
SHD2_k127_4723121_2 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000003297 235.0
SHD2_k127_4723121_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000008225 218.0
SHD2_k127_4723121_4 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000003531 102.0
SHD2_k127_4723121_5 PTS system mannose/fructose/sorbose family IID component K02796,K19509 - - 0.0000000000000000003253 97.0
SHD2_k127_4723121_6 PTS system sorbose-specific iic component K02746 - - 0.00000004784 63.0
SHD2_k127_4723121_7 PTS system sorbose subfamily IIB component K02793,K02794 - 2.7.1.191 0.0000004411 55.0
SHD2_k127_4726192_0 Fibronectin type III domain - - - 0.000000000000000265 91.0
SHD2_k127_4726192_1 transcriptional regulator, SARP family - - - 0.00000000000009543 83.0
SHD2_k127_4734608_0 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 307.0
SHD2_k127_4734608_1 Protein of unknown function (DUF2723) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 314.0
SHD2_k127_4734608_2 - - - - 0.000000003796 66.0
SHD2_k127_4734608_3 peptidyl-tyrosine sulfation - - - 0.00000002512 63.0
SHD2_k127_4754025_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 433.0
SHD2_k127_4754025_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000003251 274.0
SHD2_k127_4754025_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000001151 138.0
SHD2_k127_4759237_0 4Fe-4S binding domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 340.0
SHD2_k127_4759237_1 FAD linked oxidases, C-terminal domain K11472 - - 0.0000000000000000000000000000000000000000000000000001318 205.0
SHD2_k127_4759237_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000005026 147.0
SHD2_k127_4824925_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 534.0
SHD2_k127_4824925_1 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 384.0
SHD2_k127_4824925_2 YidE YbjL duplication domain protein K07085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 360.0
SHD2_k127_4824925_3 PhoD-like phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006778 280.0
SHD2_k127_4824925_4 Pyruvate phosphate dikinase, PEP pyruvate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000001097 219.0
SHD2_k127_4824925_5 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000497 125.0
SHD2_k127_4824925_6 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000004336 103.0
SHD2_k127_4824925_7 - - - - 0.00006843 55.0
SHD2_k127_4824971_0 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 383.0
SHD2_k127_4824971_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000276 226.0
SHD2_k127_4824971_2 Putative modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000857 148.0
SHD2_k127_4846316_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 3.055e-258 810.0
SHD2_k127_4846316_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016625,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0047553,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 452.0
SHD2_k127_4846316_2 BtpA family K06971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001832 256.0
SHD2_k127_4846316_3 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001046 237.0
SHD2_k127_4846316_4 - - - - 0.0000000000000000000000000000000000000000001077 175.0
SHD2_k127_4846316_5 Belongs to the UPF0109 family K06960 - - 0.0000000000000007214 83.0
SHD2_k127_4846316_6 extracellular matrix structural constituent - - - 0.00000003183 66.0
SHD2_k127_484658_0 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 424.0
SHD2_k127_484658_1 GYD domain - - - 0.0000000000000000000000001033 116.0
SHD2_k127_484658_2 LVIVD repeat K01179 - 3.2.1.4 0.000000000000000007671 98.0
SHD2_k127_484658_3 Parallel beta-helix repeats - - - 0.000000000421 73.0
SHD2_k127_4916042_0 Nitrate reductase alpha subunit K17050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 351.0
SHD2_k127_4916042_1 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 335.0
SHD2_k127_4916042_2 PFAM Cytochrome b b6 domain - - - 0.0000000000000000000000000000009402 126.0
SHD2_k127_4916042_3 Belongs to the glycosyl hydrolase 43 family K22350 - 1.16.3.3 0.0008576 48.0
SHD2_k127_4920376_0 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002029 266.0
SHD2_k127_4920376_1 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000003577 211.0
SHD2_k127_4920376_2 Capsule assembly protein Wzi - - - 0.000000000000000000000000000007322 131.0
SHD2_k127_4932343_0 6-phosphofructokinase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007117 467.0
SHD2_k127_4932343_1 phosphoglycerate kinase activity K00927,K01803 GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3,5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 462.0
SHD2_k127_4932343_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 444.0
SHD2_k127_4932343_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 293.0
SHD2_k127_4932343_4 long-chain fatty acid transport protein - - - 0.00000000000000000000000000000000000000000000000000000006037 209.0
SHD2_k127_4932343_5 Peptidase M56 - - - 0.00000000000000000000006677 114.0
SHD2_k127_4932343_6 PFAM Preprotein translocase SecG subunit K03075 - - 0.00000000000001955 81.0
SHD2_k127_4932343_7 - - - - 0.00000000004158 77.0
SHD2_k127_4946931_0 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 460.0
SHD2_k127_4946931_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 405.0
SHD2_k127_4946931_10 Transglycosylase SLT domain K08307 - - 0.000000000000000000000000000000000000000000000000000001615 211.0
SHD2_k127_4946931_11 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.00000000000000000000000000000000000000000000000000001705 192.0
SHD2_k127_4946931_12 RNA polymerase sigma factor K02405 - - 0.00000000000000000000000000000000000000000000000000004756 198.0
SHD2_k127_4946931_13 SRP54-type protein, GTPase domain K02404 - - 0.0000000000000000000000000000000000000000000000000007589 195.0
SHD2_k127_4946931_14 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000000000000000002859 186.0
SHD2_k127_4946931_15 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000003348 190.0
SHD2_k127_4946931_16 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000001656 172.0
SHD2_k127_4946931_17 Flagella basal body rod protein K02392 - - 0.000000000000000000000000000000000000000000004071 173.0
SHD2_k127_4946931_18 SMART metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000265 148.0
SHD2_k127_4946931_19 COG0455 ATPases involved in chromosome partitioning K04562 - - 0.0000000000000000000000001422 123.0
SHD2_k127_4946931_2 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 389.0
SHD2_k127_4946931_20 Chemotaxis phosphatase CheX - - - 0.0000000000000001327 85.0
SHD2_k127_4946931_21 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000004646 80.0
SHD2_k127_4946931_22 Rod binding protein K02395 - - 0.000000000334 73.0
SHD2_k127_4946931_23 FlgN protein - - - 0.000000002154 68.0
SHD2_k127_4946931_24 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.00000001559 65.0
SHD2_k127_4946931_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 366.0
SHD2_k127_4946931_4 Flagella basal body rod protein K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 324.0
SHD2_k127_4946931_5 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 328.0
SHD2_k127_4946931_6 Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008515 323.0
SHD2_k127_4946931_7 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004233 276.0
SHD2_k127_4946931_8 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001791 284.0
SHD2_k127_4946931_9 Flagella basal body rod protein K02396 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001603 274.0
SHD2_k127_4950106_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 558.0
SHD2_k127_4950106_1 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 305.0
SHD2_k127_4950106_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000001054 216.0
SHD2_k127_4950106_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000202 211.0
SHD2_k127_4950106_4 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001674 190.0
SHD2_k127_4950106_5 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000396 175.0
SHD2_k127_4950106_6 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000004571 167.0
SHD2_k127_4950106_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.000000000000000000000000000000000001669 138.0
SHD2_k127_4950106_8 ribosomal protein l30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000001071 73.0
SHD2_k127_4950106_9 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000004708 69.0
SHD2_k127_5022254_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 504.0
SHD2_k127_5022254_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006765 381.0
SHD2_k127_5022254_2 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008119 265.0
SHD2_k127_5022254_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000002508 97.0
SHD2_k127_5022254_4 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000855 72.0
SHD2_k127_5025619_0 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 518.0
SHD2_k127_5025619_1 BNR repeat-like domain - - - 0.000000000000000001319 101.0
SHD2_k127_5025619_2 Domain of unknown function (DUF2341) K03561 - - 0.00000000000000004916 96.0
SHD2_k127_5041298_0 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001402 269.0
SHD2_k127_5041298_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000126 217.0
SHD2_k127_5041298_2 Multicopper oxidase K04753 - - 0.000000000000000000000000000000000000000002868 180.0
SHD2_k127_5041298_3 extracellular matrix structural constituent - - - 0.00000000005213 77.0
SHD2_k127_5085833_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 1.727e-241 769.0
SHD2_k127_5085833_1 Winged helix-turn-helix domain (DUF2582) - - - 0.00000000005596 66.0
SHD2_k127_5116686_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520,K20447,K20448 - 1.17.1.5,1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 632.0
SHD2_k127_5116686_1 gas vesicle protein - - - 0.00000731 51.0
SHD2_k127_5178572_0 diguanylate cyclase - - - 0.000000000000000000000000000002695 136.0
SHD2_k127_5178572_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.00000000000000000000002731 101.0
SHD2_k127_5190316_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000004076 223.0
SHD2_k127_5190316_1 PFAM 4Fe-4S K00184 - - 0.00000000000000000000000000000000000000000003746 164.0
SHD2_k127_5190316_2 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000007056 69.0
SHD2_k127_5190316_3 Histidine kinase HAMP - - - 0.00000005301 64.0
SHD2_k127_5219295_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.468e-224 711.0
SHD2_k127_5219295_1 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005983 504.0
SHD2_k127_5219295_10 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000184 277.0
SHD2_k127_5219295_11 PFAM Integrase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000001252 246.0
SHD2_k127_5219295_12 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000008786 221.0
SHD2_k127_5219295_13 negative regulation of ribosome biogenesis K00969,K09710 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 0.0000000000000000000000000000004335 131.0
SHD2_k127_5219295_14 - - - - 0.000000000000001452 87.0
SHD2_k127_5219295_2 tRNA nucleotidyltransferase domain 2 putative K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 416.0
SHD2_k127_5219295_3 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 393.0
SHD2_k127_5219295_4 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 357.0
SHD2_k127_5219295_5 family 5 K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 329.0
SHD2_k127_5219295_6 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 304.0
SHD2_k127_5219295_7 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003944 284.0
SHD2_k127_5219295_8 phosphoribosylformylglycinamidine cyclo-ligase activity K01933,K11788 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000001321 275.0
SHD2_k127_5219295_9 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007556 277.0
SHD2_k127_5314830_0 PFAM Aspartate glutamate uridylate kinase K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008314 337.0
SHD2_k127_5314830_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001726 291.0
SHD2_k127_5314830_10 Domain of unknown function (DUF296) K06934 - - 0.00006763 47.0
SHD2_k127_5314830_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001931 294.0
SHD2_k127_5314830_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000007157 184.0
SHD2_k127_5314830_4 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000001279 171.0
SHD2_k127_5314830_5 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000002409 172.0
SHD2_k127_5314830_6 Sporulation and spore germination K06298 - - 0.00000000000000000000000534 109.0
SHD2_k127_5314830_7 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000004709 94.0
SHD2_k127_5314830_9 - - - - 0.000001403 57.0
SHD2_k127_5320497_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337,K05572 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 354.0
SHD2_k127_5320497_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 329.0
SHD2_k127_5320497_2 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000002933 192.0
SHD2_k127_5320497_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03615,K05580 - 1.6.5.3 0.0000000000000000000000000000000000000009353 167.0
SHD2_k127_5320497_4 PFAM NADH-ubiquinone plastoquinone oxidoreductase, chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000000001612 139.0
SHD2_k127_5320497_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000004375 121.0
SHD2_k127_532058_0 magnesium chelatase K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 584.0
SHD2_k127_532058_1 von Willebrand factor (vWF) type A domain K07114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 407.0
SHD2_k127_532058_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000006494 198.0
SHD2_k127_532058_3 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000004088 110.0
SHD2_k127_5334717_0 domain, Protein K20276 - - 0.00000000000000000000000000000000000000000000000006259 193.0
SHD2_k127_5334717_1 HD domain - - - 0.0000000000000000000000000000000000000006971 169.0
SHD2_k127_5375255_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 425.0
SHD2_k127_5375255_1 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 403.0
SHD2_k127_5375255_2 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.000000000000000000000000000000000000000000000000001367 194.0
SHD2_k127_5375255_3 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000006003 142.0
SHD2_k127_5375255_4 Cold-shock protein K03704 - - 0.00000000000000000000000000009167 118.0
SHD2_k127_5382235_0 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 403.0
SHD2_k127_5382235_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001307 243.0
SHD2_k127_5382235_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000001224 91.0
SHD2_k127_5382235_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000003378 63.0
SHD2_k127_5383032_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000002615 243.0
SHD2_k127_5383032_1 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000001047 184.0
SHD2_k127_5383032_2 palmitoyl-(protein) hydrolase activity K06999 - - 0.0000000000000000000000000000000000000002032 159.0
SHD2_k127_5383032_3 Enolase, C-terminal TIM barrel domain K01689 - 4.2.1.11 0.00000000001025 65.0
SHD2_k127_5383032_4 - - - - 0.0000003975 53.0
SHD2_k127_5424565_0 OPT oligopeptide transporter protein - - - 1.779e-201 644.0
SHD2_k127_5424565_1 NADH flavin oxidoreductase NADH oxidase K00354 - 1.6.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 421.0
SHD2_k127_5424565_10 Fungal trichothecene efflux pump (TRI12) - - - 0.000007203 57.0
SHD2_k127_5424565_2 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007394 303.0
SHD2_k127_5424565_3 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000005625 244.0
SHD2_k127_5424565_4 metallopeptidase activity K06974 - - 0.0000000000000000000000000000001205 132.0
SHD2_k127_5424565_5 Trypsin-like serine protease K01337 - 3.4.21.50 0.00000000000000000000000004907 122.0
SHD2_k127_5424565_6 Trypsin-like serine protease K01337 - 3.4.21.50 0.000000000000000000003627 108.0
SHD2_k127_5424565_7 Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000001127 79.0
SHD2_k127_5424565_8 protein histidine kinase activity - - - 0.000000000002253 80.0
SHD2_k127_5424565_9 Bacterial Ig-like domain (group 1) - - - 0.00000002264 66.0
SHD2_k127_5445254_0 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.0 1064.0
SHD2_k127_5445254_1 Major Facilitator Superfamily K02445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 434.0
SHD2_k127_5445254_2 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001022 252.0
SHD2_k127_5445254_3 - - - - 0.00000000000000000000000000000000000000000005564 164.0
SHD2_k127_5445254_4 - - - - 0.0000000000009008 77.0
SHD2_k127_5462237_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 511.0
SHD2_k127_5462237_1 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 499.0
SHD2_k127_5462237_10 PFAM SMP-30 Gluconolaconase - - - 0.00000000002106 71.0
SHD2_k127_5462237_11 Antioxidant AhpC TSA family K03564 - 1.11.1.15 0.0000000001797 64.0
SHD2_k127_5462237_2 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008553 372.0
SHD2_k127_5462237_3 AsnC-type helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 357.0
SHD2_k127_5462237_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000005033 227.0
SHD2_k127_5462237_5 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000004064 189.0
SHD2_k127_5462237_6 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000002571 138.0
SHD2_k127_5462237_7 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000698 127.0
SHD2_k127_5462237_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000005998 133.0
SHD2_k127_5462237_9 AhpC/TSA family K03564 - 1.11.1.15 0.0000000000000000000000001515 109.0
SHD2_k127_5468802_0 Major facilitator Superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 423.0
SHD2_k127_5468802_1 dna ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 415.0
SHD2_k127_5468802_10 with different specificities (related to short-chain alcohol K00059 - 1.1.1.100 0.0000000004463 62.0
SHD2_k127_5468802_2 PFAM ATP dependent DNA ligase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 399.0
SHD2_k127_5468802_3 Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway K00068,K18124,K18125 GO:0000166,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005515,GO:0005534,GO:0005536,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006012,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009987,GO:0016043,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019320,GO:0019388,GO:0019595,GO:0022607,GO:0030246,GO:0033498,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046430,GO:0046872,GO:0046914,GO:0046983,GO:0047910,GO:0047936,GO:0048029,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051262,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.140,1.1.1.359,1.1.1.360 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004083 336.0
SHD2_k127_5468802_4 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000002519 275.0
SHD2_k127_5468802_5 - - - - 0.0000000000000000000000000000000000000000000000000001279 198.0
SHD2_k127_5468802_6 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000005461 194.0
SHD2_k127_5468802_7 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000005177 134.0
SHD2_k127_5468802_8 Trypsin-like serine protease K01337 - 3.4.21.50 0.0000000000000000000001552 113.0
SHD2_k127_5468802_9 - - - - 0.0000000000000001333 83.0
SHD2_k127_5483209_0 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005848 359.0
SHD2_k127_5483209_1 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.00000000000000000000636 104.0
SHD2_k127_5489832_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K11392 - 2.1.1.178 0.00000000000000000000000000000000000000000000000000000000000000000000000000003241 270.0
SHD2_k127_5489832_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006191 267.0
SHD2_k127_5489832_2 PBS lyase HEAT-like repeat - - - 0.0000000000000000000000002546 117.0
SHD2_k127_5489832_3 Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA - - - 0.000000000000000009321 93.0
SHD2_k127_5489832_4 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000002203 59.0
SHD2_k127_5492563_0 FlgD Ig-like domain K21449 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005394 259.0
SHD2_k127_5492563_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000005211 206.0
SHD2_k127_5492563_2 Zinc metalloprotease (Elastase) - - - 0.00000000000000000000000000000000000000000000000000003646 215.0
SHD2_k127_5492563_3 Evidence 5 No homology to any previously reported sequences K01361,K13277 - 3.4.21.96 0.00000000002349 78.0
SHD2_k127_5498501_0 Methylenetetrahydrofolate reductase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 497.0
SHD2_k127_5498501_1 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 389.0
SHD2_k127_5498501_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738,K12339,K21949 - 2.5.1.140,2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005165 312.0
SHD2_k127_5498501_3 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 317.0
SHD2_k127_5498501_4 peptidyl-prolyl isomerase K03769,K03770 - 5.2.1.8 0.000000000000171 84.0
SHD2_k127_5501903_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 2.033e-200 643.0
SHD2_k127_5501903_1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000003107 188.0
SHD2_k127_5501903_2 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000002605 155.0
SHD2_k127_5501903_3 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000001209 158.0
SHD2_k127_5503449_0 COG1613 ABC-type sulfate transport system, periplasmic component K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 486.0
SHD2_k127_5503449_1 sulfate ABC transporter, inner membrane subunit CysT K02046,K15496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001598 270.0
SHD2_k127_5503449_2 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000317 176.0
SHD2_k127_5503449_3 Domain of unknown function (DUF309) - - - 0.00000000000000000000000000000000001466 141.0
SHD2_k127_5503449_4 Domain of unknown function (DUF1905) - - - 0.00000000000000000000000000002041 127.0
SHD2_k127_5503449_5 Transcriptional regulator - - - 0.0000000000000000000000000001493 120.0
SHD2_k127_5527222_0 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 482.0
SHD2_k127_5527222_1 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 403.0
SHD2_k127_5527222_2 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000001503 247.0
SHD2_k127_5527222_3 Anabaena sensory rhodopsin transducer - - - 0.000000000000000000000000000000000000000000000000000000000005013 209.0
SHD2_k127_5527222_4 - - - - 0.000000000000000000000000000000000000000000000001954 188.0
SHD2_k127_5527222_5 DoxX K15977 - - 0.000000000000000000000000000000000000005771 149.0
SHD2_k127_5527222_6 Cytochrome c - - - 0.0000000000000000000000000000000002119 138.0
SHD2_k127_5527222_7 PFAM PKD domain containing protein - - - 0.000000000000004174 91.0
SHD2_k127_5527222_8 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000007646 73.0
SHD2_k127_5527222_9 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 0.000001293 63.0
SHD2_k127_5570101_0 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 585.0
SHD2_k127_5570101_1 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 354.0
SHD2_k127_5570101_2 DUF3160 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008773 284.0
SHD2_k127_5570101_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004045 273.0
SHD2_k127_5570101_4 Bacterial capsule synthesis protein K07282 - - 0.00000000000000000000000000000000000000000000000001046 198.0
SHD2_k127_5583891_0 glycogen (starch) synthase activity K16148 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576 2.4.1.342 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 588.0
SHD2_k127_5583891_1 Mur ligase middle domain K01925,K01932 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005644 284.0
SHD2_k127_5583891_2 - - - - 0.000000000000000000000000000000000000000000000000000000000001704 226.0
SHD2_k127_5583891_3 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000001107 217.0
SHD2_k127_5583891_4 - - - - 0.0000000000000000000000000000000000000000000000008624 181.0
SHD2_k127_5583891_5 Capsule biosynthesis CapC K22116 - - 0.00000000000000000000000000000002978 132.0
SHD2_k127_5583891_6 Domain of unknown function (DUF4342) - - - 0.00000000000000000000004508 101.0
SHD2_k127_5583891_7 - - - - 0.00000000000000000002488 91.0
SHD2_k127_5583891_8 O-methyltransferase family 3 - - - 0.000001866 52.0
SHD2_k127_5592228_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 536.0
SHD2_k127_5592228_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 516.0
SHD2_k127_5592228_2 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 377.0
SHD2_k127_5592228_3 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 364.0
SHD2_k127_5592228_4 Catalyzes the specific phosphorylation of arginine residues in proteins K19405 - 2.7.14.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 325.0
SHD2_k127_5592228_5 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778 - 0.000000000000000000000000000000000000000000000000000000000000000001991 242.0
SHD2_k127_5592228_6 protein with conserved CXXC pairs K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 - 0.00000000000000000000000000000000000003007 149.0
SHD2_k127_5596099_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 5.423e-239 748.0
SHD2_k127_5596099_1 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 3.158e-202 651.0
SHD2_k127_5596099_2 TIGRFAM ornithine aminotransferase K00819 - 2.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 556.0
SHD2_k127_5596099_3 carboxylase, biotin carboxylase K01961,K01965,K01968,K11263 - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 522.0
SHD2_k127_5596099_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759,K05606 - 4.4.1.5,5.1.99.1 0.00000000000000000000000000000004789 144.0
SHD2_k127_5596099_5 Biotin-requiring enzyme - - - 0.00000000000166 77.0
SHD2_k127_5596099_6 oligoendopeptidase F K08602 - - 0.000009616 55.0
SHD2_k127_5597001_0 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005083 370.0
SHD2_k127_5597001_1 phosphonoacetaldehyde hydrolase activity K00817,K07025,K20866 - 2.6.1.9,3.1.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002738 280.0
SHD2_k127_5597001_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K12976,K22110 - - 0.00000000000000000004018 103.0
SHD2_k127_5605098_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0 1127.0
SHD2_k127_5605098_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0 1126.0
SHD2_k127_5618474_0 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.000000000000000000000000000000000000000000000000000000000000001155 233.0
SHD2_k127_5618474_1 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000005402 220.0
SHD2_k127_5618474_2 Nitroreductase family - - - 0.0000000000000000000000000000000000000003257 156.0
SHD2_k127_5618474_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000474 154.0
SHD2_k127_5618474_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752,K13818 - 2.7.7.77 0.00000000000000000000000000001246 126.0
SHD2_k127_5618474_5 - - - - 0.0000000000000000000000000003771 127.0
SHD2_k127_5618474_6 Putative zinc ribbon domain - - - 0.000000000001965 68.0
SHD2_k127_5618474_7 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00002407 57.0
SHD2_k127_5618474_8 COG0526, thiol-disulfide isomerase and thioredoxins K03671 - - 0.00004623 51.0
SHD2_k127_5618474_9 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.00005541 56.0
SHD2_k127_5622578_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 318.0
SHD2_k127_5622578_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004734 298.0
SHD2_k127_5622578_2 Deoxynucleoside kinase K15518 - 2.7.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000004776 245.0
SHD2_k127_5622578_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000001609 252.0
SHD2_k127_5622578_4 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000000000000000000004172 168.0
SHD2_k127_5625640_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 498.0
SHD2_k127_5625640_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 339.0
SHD2_k127_5625640_2 MATE efflux family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000208 255.0
SHD2_k127_5625640_3 PFAM Glycosyl transferases group 1 K16703 - - 0.000000000000000000000000000000000000000000000000000001447 209.0
SHD2_k127_5625640_4 Photosynthesis system II assembly factor YCF48 - - - 0.0000000000001053 85.0
SHD2_k127_5625640_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000001144 69.0
SHD2_k127_5625640_6 aminopeptidase activity - - - 0.0000259 58.0
SHD2_k127_5630801_0 PFAM Asparagine synthase K01953 - 6.3.5.4 1.177e-224 716.0
SHD2_k127_5630801_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 472.0
SHD2_k127_5630801_2 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000005591 162.0
SHD2_k127_5724001_0 lipid A export permease ATP-binding protein MsbA K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 427.0
SHD2_k127_5724001_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 334.0
SHD2_k127_5724001_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000001718 142.0
SHD2_k127_5724001_3 - K07275 - - 0.0000000000000000000000000001062 127.0
SHD2_k127_5724001_4 Protein of unknown function (DUF1326) - - - 0.0001428 50.0
SHD2_k127_5724733_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002295 285.0
SHD2_k127_5724733_1 arsR family K03892 - - 0.00000000003752 71.0
SHD2_k127_5724733_2 phosphorelay sensor kinase activity K13598 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000008128 58.0
SHD2_k127_5737548_0 Glycosyl hydrolase family 63 C-terminal domain - - - 0.0 1319.0
SHD2_k127_5737548_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 554.0
SHD2_k127_5739276_0 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000002989 192.0
SHD2_k127_5739276_1 NHL repeat - - - 0.000004835 58.0
SHD2_k127_576728_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 589.0
SHD2_k127_576728_1 Cytochrome c - - - 0.0000004574 60.0
SHD2_k127_5774566_0 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 504.0
SHD2_k127_5774566_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 343.0
SHD2_k127_5774566_2 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000149 79.0
SHD2_k127_5781917_0 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.0000000000000000000000000000000000000000000000000000000174 225.0
SHD2_k127_5781917_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000006438 214.0
SHD2_k127_5781917_2 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000002016 154.0
SHD2_k127_5781917_3 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000002132 153.0
SHD2_k127_5781917_4 Periplasmic copper-binding protein (NosD) - - - 0.0000000005979 73.0
SHD2_k127_5781917_5 collagen metabolic process K08677 - - 0.0000001639 66.0
SHD2_k127_5781917_6 S-layer homology domain - - - 0.000007708 60.0
SHD2_k127_5781917_7 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0002498 54.0
SHD2_k127_5784358_0 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005119 462.0
SHD2_k127_5784358_1 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 377.0
SHD2_k127_5784358_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 335.0
SHD2_k127_5784358_3 Abc transporter K01995 - - 0.0000000000000000000000000000000000000007075 154.0
SHD2_k127_5784358_4 BNR repeat-like domain - - - 0.00000000009851 75.0
SHD2_k127_578842_0 Bacterial sugar transferase - - - 0.0000000000000000000000000000000000000000000000000000002394 211.0
SHD2_k127_578842_1 TIGRFAM sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family K13006 - - 0.00000000000000000000000000000000000000000000005029 178.0
SHD2_k127_578842_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000002091 155.0
SHD2_k127_578842_3 PFAM Methicillin resistance protein - - - 0.000000000000000000007897 107.0
SHD2_k127_578842_4 Polysaccharide biosynthesis protein K03328 - - 0.000001078 61.0
SHD2_k127_578842_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000121 59.0
SHD2_k127_5802710_0 Nickel-dependent hydrogenase K14126 - 1.8.98.5 5.203e-205 653.0
SHD2_k127_5802710_1 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 481.0
SHD2_k127_5802710_2 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 393.0
SHD2_k127_5802710_3 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000002038 208.0
SHD2_k127_5802710_4 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000005815 203.0
SHD2_k127_5802710_5 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000001226 180.0
SHD2_k127_5802710_6 Hydrogenase maturation protease K03605 - - 0.00000000000000874 79.0
SHD2_k127_5816961_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 2.616e-197 642.0
SHD2_k127_5816961_1 DHH family K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 466.0
SHD2_k127_5816961_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008774 317.0
SHD2_k127_5816961_3 amine dehydrogenase activity - - - 0.0000002179 58.0
SHD2_k127_5816961_4 Two component regulator propeller - - - 0.0003394 53.0
SHD2_k127_5821826_0 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000001977 237.0
SHD2_k127_5821826_1 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000002437 237.0
SHD2_k127_5821826_2 Pilus assembly protein, PilO K02664 - - 0.000000000000000005822 93.0
SHD2_k127_5821826_3 PFAM Fimbrial assembly K02663 - - 0.000000001006 72.0
SHD2_k127_5821826_4 Tetratricopeptide repeat - - - 0.00003161 49.0
SHD2_k127_5824453_0 Belongs to the peptidase S8 family K01280 - 3.4.14.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 441.0
SHD2_k127_5824453_1 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000007399 261.0
SHD2_k127_5824453_2 two component, sigma54 specific, transcriptional regulator, Fis family K11384 - - 0.000007527 56.0
SHD2_k127_5868812_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 490.0
SHD2_k127_5868812_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007736 306.0
SHD2_k127_5868812_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000003693 255.0
SHD2_k127_5868812_3 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000009712 135.0
SHD2_k127_5868812_4 - - - - 0.000000003505 66.0
SHD2_k127_5891285_0 Beta-eliminating lyase K01667 - 4.1.99.1 2.034e-197 626.0
SHD2_k127_5891285_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 512.0
SHD2_k127_5891285_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000002557 239.0
SHD2_k127_5891285_3 - - - - 0.00000000000093 79.0
SHD2_k127_5891285_4 Tetratricopeptide repeat - - - 0.0000000001632 74.0
SHD2_k127_5891285_5 COG3209 Rhs family protein - - - 0.0000003811 63.0
SHD2_k127_5932864_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.772e-262 832.0
SHD2_k127_5932864_1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000003917 256.0
SHD2_k127_5932864_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007222 261.0
SHD2_k127_5932864_3 FES K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000008413 229.0
SHD2_k127_5932864_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000004813 173.0
SHD2_k127_5932864_5 TM2 domain - - - 0.000000000006412 74.0
SHD2_k127_593523_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K00087 - 1.17.1.4 1.855e-264 861.0
SHD2_k127_593523_1 Belongs to the thiolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000305 250.0
SHD2_k127_593523_2 3-hydroxyacyl-CoA dehydrogenase K00074 GO:0003674,GO:0003824,GO:0003857,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0008691,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000001455 229.0
SHD2_k127_593523_3 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM-like protein K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000115 206.0
SHD2_k127_593523_4 carbon monoxide dehydrogenase small subunit K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000006429 202.0
SHD2_k127_593523_5 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K01661 - 4.1.3.36 0.00000003408 57.0
SHD2_k127_5937063_0 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 307.0
SHD2_k127_5937063_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001434 259.0
SHD2_k127_5937063_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000001863 196.0
SHD2_k127_5937063_3 Fe-S oxidoreductase K18928 - - 0.000000000000000000000000000000000000000538 154.0
SHD2_k127_5937063_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000001281 135.0
SHD2_k127_5937063_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000006439 107.0
SHD2_k127_5947682_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 451.0
SHD2_k127_5947682_1 TIGRFAM pseudaminic acid synthase K01654 - 2.5.1.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 400.0
SHD2_k127_5947682_2 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008637 298.0
SHD2_k127_5947682_3 transferase activity, transferring amino-acyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004135 242.0
SHD2_k127_5947682_4 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000004099 233.0
SHD2_k127_5947682_5 PFAM polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000006616 251.0
SHD2_k127_5947682_6 Cytidylyltransferase - - - 0.000000000000000000000000000000000003366 149.0
SHD2_k127_5947682_7 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.0000000000000000000000000002429 129.0
SHD2_k127_5947682_8 TIGRFAM pseudaminic acid biosynthesis-associated protein PseG - - - 0.0000000000000000000001784 113.0
SHD2_k127_5947682_9 Capsule polysaccharide biosynthesis protein - - - 0.0000000004276 73.0
SHD2_k127_5950962_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 518.0
SHD2_k127_5950962_1 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000002507 163.0
SHD2_k127_5950962_2 Tetratricopeptide repeat - - - 0.00000001919 66.0
SHD2_k127_5985177_0 Glycosyl transferase 4-like domain K08256,K12995 - 2.4.1.345,2.4.1.348 0.00000000000000000000000000000000000000000000000002577 199.0
SHD2_k127_5985177_1 Transmembrane secretion effector - - - 0.0000000000000000000000000008694 132.0
SHD2_k127_5985177_2 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000002343 67.0
SHD2_k127_6015521_0 Soluble NSF attachment protein, SNAP - - - 0.000000000000000000000000000000000000000002367 180.0
SHD2_k127_6015521_1 COG1595 DNA-directed RNA polymerase specialized sigma K03088 - - 0.0000000000000000083 91.0
SHD2_k127_6049448_0 FAD dependent oxidoreductase - - - 4.129e-203 646.0
SHD2_k127_6049448_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 558.0
SHD2_k127_6049448_2 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006548 467.0
SHD2_k127_6049448_3 DEAD DEAH box helicase K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 441.0
SHD2_k127_6049448_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000001103 172.0
SHD2_k127_6049448_5 Domain of unknown function (DUF4932) - - - 0.000000000002561 70.0
SHD2_k127_6059857_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 474.0
SHD2_k127_6059857_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003399 278.0
SHD2_k127_6059857_2 major facilitator superfamily - - - 0.000000000000000000000000000000000004313 143.0
SHD2_k127_6059857_3 Acylphosphatase K01512 - 3.6.1.7 0.00000000000000000000000141 108.0
SHD2_k127_6059857_4 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.000000001894 69.0
SHD2_k127_606637_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 306.0
SHD2_k127_606637_1 MotA/TolQ/ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000001439 238.0
SHD2_k127_606637_2 biopolymer transport protein K03559 - - 0.0000000000000000000000000000000009735 136.0
SHD2_k127_606637_3 Tetratricopeptide repeat - - - 0.00000000000000000009755 105.0
SHD2_k127_606637_4 PBP superfamily domain K02040 - - 0.000000000000000001331 97.0
SHD2_k127_606637_5 PFAM Biopolymer transport protein ExbD TolR - - - 0.0000000000001558 78.0
SHD2_k127_606637_6 Tetratricopeptide repeat - - - 0.000005096 60.0
SHD2_k127_606637_7 STAS domain K04749 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0005554 51.0
SHD2_k127_607825_0 Bacterial protein of unknown function (DUF853) K06915 - - 4.668e-206 651.0
SHD2_k127_607825_1 Queuosine biosynthesis protein QueC K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000001889 229.0
SHD2_k127_607825_2 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000009948 237.0
SHD2_k127_607825_3 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000001041 144.0
SHD2_k127_6103543_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1175.0
SHD2_k127_6103543_1 4fe-4S ferredoxin, iron-sulfur binding domain protein K00207,K00219,K00317,K02293,K10797,K12527,K17723 - 1.3.1.1,1.3.1.2,1.3.1.31,1.3.1.34,1.3.5.5,1.5.8.1,1.5.8.2,1.97.1.9 3.289e-279 886.0
SHD2_k127_6103543_2 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 524.0
SHD2_k127_6103543_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 495.0
SHD2_k127_6103543_4 acyl-coa dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000766 434.0
SHD2_k127_6103543_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 318.0
SHD2_k127_6103543_6 methylated-DNA-[protein]-cysteine S-methyltransferase activity K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000000005738 169.0
SHD2_k127_6103543_7 Cold-shock protein K03704 - - 0.0000000000000000000000000002476 117.0
SHD2_k127_6110587_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 473.0
SHD2_k127_6110587_1 response regulator receiver - - - 0.000000000000000000000000000002563 134.0
SHD2_k127_6110587_2 overlaps another CDS with the same product name - - - 0.0000000000000000000000001359 115.0
SHD2_k127_6110587_3 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000008682 113.0
SHD2_k127_6116053_0 PFAM Peptidase M16 inactive domain - - - 0.000000000000000000000000000000000000000000003422 183.0
SHD2_k127_6116053_1 aminoacyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000008458 165.0
SHD2_k127_6116053_2 Belongs to the peptidase M16 family - - - 0.000000000002314 77.0
SHD2_k127_614090_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 458.0
SHD2_k127_614090_1 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000006513 167.0
SHD2_k127_614090_2 - - - - 0.0000002245 63.0
SHD2_k127_614132_0 radical SAM domain protein K22226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 544.0
SHD2_k127_614132_1 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 458.0
SHD2_k127_614132_2 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000009915 211.0
SHD2_k127_614132_3 Penicillin-Binding Protein C-terminus Family - - - 0.00000000000000000000000000000000000000001767 164.0
SHD2_k127_6155653_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 469.0
SHD2_k127_6155653_1 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 442.0
SHD2_k127_6155653_2 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007257 349.0
SHD2_k127_6155653_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 337.0
SHD2_k127_6155653_4 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000001065 175.0
SHD2_k127_6213365_0 Uncharacterized protein family (UPF0051) K09014 - - 1.172e-274 853.0
SHD2_k127_6213365_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 565.0
SHD2_k127_6213365_2 ABC transporter K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 383.0
SHD2_k127_6213365_3 Uncharacterized protein family (UPF0051) K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007947 390.0
SHD2_k127_6213365_4 transcriptional regulator - - - 0.0000007005 54.0
SHD2_k127_6215423_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 447.0
SHD2_k127_6215423_1 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 323.0
SHD2_k127_6215423_2 TIGRFAM DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009074 286.0
SHD2_k127_6215423_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000007255 265.0
SHD2_k127_6215423_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000003424 199.0
SHD2_k127_6215423_5 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000003103 113.0
SHD2_k127_6215423_6 zinc-ribbon domain - - - 0.0000000000000000000001293 115.0
SHD2_k127_6215423_7 cell adhesion involved in biofilm formation - - - 0.00000000002793 78.0
SHD2_k127_6256855_0 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001958 258.0
SHD2_k127_6256855_1 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000002336 169.0
SHD2_k127_6256855_2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.000000000000000000000000000000000000009365 153.0
SHD2_k127_6317793_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 433.0
SHD2_k127_6317793_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004847 285.0
SHD2_k127_6317793_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000007423 219.0
SHD2_k127_6317793_3 peptidase K04773 - - 0.0000000000000000000000000000000000239 156.0
SHD2_k127_6334808_0 TonB-dependent receptor K02014 - - 2.004e-233 749.0
SHD2_k127_6334808_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 424.0
SHD2_k127_6334808_2 symporter activity K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 345.0
SHD2_k127_6334808_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000002789 182.0
SHD2_k127_6334808_4 Methyltransferase domain - - - 0.000000000000000000000000000000000000227 154.0
SHD2_k127_6338855_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 422.0
SHD2_k127_6338855_1 bacterial-type flagellum-dependent cell motility K01119,K06113,K12685,K20276 - 3.1.3.6,3.1.4.16,3.2.1.99 0.000000000457 74.0
SHD2_k127_6338855_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.1,3.5.4.33 0.0000002778 52.0
SHD2_k127_6362615_0 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 515.0
SHD2_k127_6362615_1 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 463.0
SHD2_k127_6362615_2 inositol 2-dehydrogenase activity K13016 - 1.1.1.335 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 424.0
SHD2_k127_6362615_3 Sigma-54 interaction domain K02481,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 385.0
SHD2_k127_6362615_4 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008181 317.0
SHD2_k127_6362615_5 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003762 279.0
SHD2_k127_6362615_6 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000001099 238.0
SHD2_k127_6362615_7 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000004917 216.0
SHD2_k127_6362615_8 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000007321 128.0
SHD2_k127_6362615_9 Cyclic nucleotide-monophosphate binding domain - - - 0.000000001387 65.0
SHD2_k127_6364347_0 Major Facilitator Superfamily K02445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 375.0
SHD2_k127_6364347_1 N-acetylglucosaminylinositol deacetylase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000007266 238.0
SHD2_k127_6364347_2 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000002073 219.0
SHD2_k127_6364347_3 Domain of unknown function (DUF4386) - - - 0.0000000000000000000000000000000000000000000000000002513 193.0
SHD2_k127_6364347_4 - - - - 0.0000000000006965 80.0
SHD2_k127_6364347_5 YCII-related domain - - - 0.00005418 46.0
SHD2_k127_6364347_6 Polymer-forming cytoskeletal - - - 0.0001297 52.0
SHD2_k127_6364604_0 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000006177 214.0
SHD2_k127_6364604_1 Propeptide_C25 - - - 0.00000000000000001183 98.0
SHD2_k127_6364604_2 Bacteriochlorophyll chlorophyll K04040 - 2.5.1.133,2.5.1.62 0.0000000000001598 76.0
SHD2_k127_6397244_0 PFAM Alcohol dehydrogenase GroES-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 562.0
SHD2_k127_6397244_1 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 491.0
SHD2_k127_6397244_2 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009943 306.0
SHD2_k127_6397244_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000001093 211.0
SHD2_k127_6397244_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000000003363 184.0
SHD2_k127_6397244_5 phosphatase activity - - - 0.0000000000000000000000000000000000000000004276 160.0
SHD2_k127_6397244_6 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000003778 164.0
SHD2_k127_6397244_7 - - - - 0.000000000000000000000000000000003018 136.0
SHD2_k127_6401634_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 2.901e-213 678.0
SHD2_k127_6401634_1 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000616 241.0
SHD2_k127_6401634_2 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000001159 220.0
SHD2_k127_6401634_3 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000008722 100.0
SHD2_k127_6401634_4 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.00000000001248 69.0
SHD2_k127_6401634_5 - - - - 0.0002061 44.0
SHD2_k127_6404412_0 Aminotransferase K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 409.0
SHD2_k127_6404412_1 PFAM DinB family - - - 0.0000000000000000000000000000000000000000000000000303 184.0
SHD2_k127_6404412_2 PFAM PEBP family protein K06910 - - 0.000000000000000003612 88.0
SHD2_k127_6404412_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000005268 98.0
SHD2_k127_6418284_0 PFAM Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009219 481.0
SHD2_k127_6418284_1 - - - - 0.000000000000005651 88.0
SHD2_k127_6424175_0 Amino acid permease - - - 1.18e-221 708.0
SHD2_k127_6424175_1 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 501.0
SHD2_k127_6424175_10 Protein tyrosine kinase - - - 0.00000000000000000000007761 115.0
SHD2_k127_6424175_11 stage II sporulation K07315 - 3.1.3.3 0.0000000000000000005903 91.0
SHD2_k127_6424175_12 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000001101 73.0
SHD2_k127_6424175_13 Evidence 5 No homology to any previously reported sequences - - - 0.000000001269 72.0
SHD2_k127_6424175_2 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 430.0
SHD2_k127_6424175_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00167,K11381,K21417 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 416.0
SHD2_k127_6424175_4 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 390.0
SHD2_k127_6424175_5 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008974 370.0
SHD2_k127_6424175_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009439 353.0
SHD2_k127_6424175_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006333 344.0
SHD2_k127_6424175_8 alginic acid biosynthetic process K01729 - 4.2.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 312.0
SHD2_k127_6424175_9 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002289 294.0
SHD2_k127_6430864_0 Tricorn protease C1 domain K08676 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000702 647.0
SHD2_k127_6430864_1 Response regulator receiver domain protein K07670 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000003799 233.0
SHD2_k127_6430864_2 histidine kinase HAMP region domain protein - - - 0.0000000000000000000005892 111.0
SHD2_k127_6448381_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004149 353.0
SHD2_k127_6448381_1 Protein of unknown function (DUF2400) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000339 255.0
SHD2_k127_6451679_0 Alcohol dehydrogenase zinc-binding domain protein K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 391.0
SHD2_k127_6451679_1 PFAM Bacterial regulatory protein, arsR family K21903 - - 0.0000000000000000000000000702 109.0
SHD2_k127_6451679_2 - - - - 0.00000000000000000000003972 112.0
SHD2_k127_6451679_3 Endonuclease I - - - 0.00000001965 66.0
SHD2_k127_6451679_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.0001815 45.0
SHD2_k127_6452568_0 COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K12528 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 451.0
SHD2_k127_6452568_1 COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K12528 - - 0.0000000000000000000000000000000000000000000000000001324 192.0
SHD2_k127_6452568_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000003342 171.0
SHD2_k127_6452568_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000002852 128.0
SHD2_k127_6452568_4 Peptidase family M50 - - - 0.000000000000000000000003755 104.0
SHD2_k127_6452568_5 Gram-negative-bacterium-type cell outer membrane assembly K06186 - - 0.00003785 56.0
SHD2_k127_645729_0 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.000000000000000000000000000000000000000000000000000001359 196.0
SHD2_k127_645729_2 Tetratricopeptide repeat - - - 0.00005757 56.0
SHD2_k127_6483455_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 509.0
SHD2_k127_6483455_1 Pkd domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 406.0
SHD2_k127_6483455_2 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006414 252.0
SHD2_k127_6483455_3 amine dehydrogenase activity - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000006221 93.0
SHD2_k127_6518304_0 Pfam:KaiC K08482 - - 3.156e-205 653.0
SHD2_k127_6518304_1 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000002676 256.0
SHD2_k127_6518304_2 KaiB K08481 - - 0.00000000000000000000000000000000000002476 146.0
SHD2_k127_6518304_3 KaiB K08481 - - 0.0000000000000000000000000000002634 127.0
SHD2_k127_6518304_4 Calcium/calmodulin dependent protein kinase II association domain - - - 0.000000000000224 78.0
SHD2_k127_6518304_5 Glycosyl hydrolase family 70 K01142,K01176 - 3.1.11.2,3.2.1.1 0.0000000000004453 79.0
SHD2_k127_6518304_6 Redoxin K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.0000000000009652 72.0
SHD2_k127_6518304_7 Redoxin K03386 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000001527 60.0
SHD2_k127_6519010_0 PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000001922 232.0
SHD2_k127_6519010_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000000000000000000000000000000000000000000006584 211.0
SHD2_k127_6519010_2 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000005003 171.0
SHD2_k127_6519010_3 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000005394 154.0
SHD2_k127_6519010_4 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000000003913 139.0
SHD2_k127_6519010_5 - - - - 0.000000000001934 75.0
SHD2_k127_6519010_6 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.00000000001306 66.0
SHD2_k127_6529012_0 PFAM FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 568.0
SHD2_k127_6529012_1 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004977 327.0
SHD2_k127_6529012_2 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005043 275.0
SHD2_k127_6529012_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002167 279.0
SHD2_k127_6529012_4 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002668 243.0
SHD2_k127_6529012_5 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000008606 197.0
SHD2_k127_6529012_6 COG1985 Pyrimidine reductase, riboflavin biosynthesis K00082,K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000001893 182.0
SHD2_k127_6529012_7 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000000000002477 164.0
SHD2_k127_6529012_8 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.000000000000000000000000000000000000002321 160.0
SHD2_k127_653048_0 Response regulator, receiver K01007 - 2.7.9.2 2.707e-227 730.0
SHD2_k127_653048_1 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 464.0
SHD2_k127_653048_2 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 417.0
SHD2_k127_653048_3 Branched-chain amino acid transport system / permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000002155 213.0
SHD2_k127_653048_4 Protein of unknown function (DUF423) - - - 0.00000000000000000000000000000000000001913 150.0
SHD2_k127_6558222_1 Zinc metalloprotease (Elastase) - - - 0.000000000000000001116 102.0
SHD2_k127_6627000_0 Zinc metalloprotease (Elastase) K20274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008319 377.0
SHD2_k127_6627000_1 peptidyl-tyrosine sulfation - - - 0.0000000009869 70.0
SHD2_k127_6627000_3 cellulose binding K00505 - 1.14.18.1 0.00000987 48.0
SHD2_k127_6653170_0 AcrB/AcrD/AcrF family K03296 - - 6.586e-321 1012.0
SHD2_k127_6653170_1 PFAM FAD linked oxidase domain protein - - - 2.85e-197 625.0
SHD2_k127_6653170_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 375.0
SHD2_k127_6653170_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000003512 173.0
SHD2_k127_6653170_4 transcriptional activator domain - - - 0.000000000000000000000000000000000000001228 171.0
SHD2_k127_6653170_5 Outer membrane efflux protein - - - 0.00000000000000000006978 104.0
SHD2_k127_6653170_6 Bacterial regulatory proteins, tetR family - - - 0.0000000000001195 79.0
SHD2_k127_6653170_7 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000006067 65.0
SHD2_k127_6653170_8 cellulase activity - - - 0.000005113 59.0
SHD2_k127_6659021_0 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 563.0
SHD2_k127_6659021_1 (ABC) transporter K06147,K06148,K11085,K16787,K18104,K18889 - 3.6.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 417.0
SHD2_k127_6659021_2 Tetratricopeptide repeat K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008253 402.0
SHD2_k127_6659021_3 ABC transporter transmembrane region K18890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 364.0
SHD2_k127_6659021_4 major facilitator superfamily MFS_1 K08225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 357.0
SHD2_k127_6659021_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K07752 - 3.4.17.18,3.4.17.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 338.0
SHD2_k127_6659021_6 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000002095 184.0
SHD2_k127_6659021_7 Exodeoxyribonuclease III - - - 0.0000000000000004629 92.0
SHD2_k127_6659021_8 Evidence 5 No homology to any previously reported sequences K03088 - - 0.00000000000004851 82.0
SHD2_k127_666561_0 Male sterility protein K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002731 274.0
SHD2_k127_666561_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005077 267.0
SHD2_k127_666561_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000004596 211.0
SHD2_k127_666561_3 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000003269 179.0
SHD2_k127_666561_4 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000001782 169.0
SHD2_k127_6678_0 Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH K22136 - - 0.000000000000000000000000000000000000001564 164.0
SHD2_k127_6691384_0 Surface antigen K07277 GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 508.0
SHD2_k127_6691384_1 Belongs to the ClpA ClpB family K03696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 432.0
SHD2_k127_6691384_2 unfolded protein binding K06142 - - 0.00000000000000000004476 106.0
SHD2_k127_6691384_3 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000004556 71.0
SHD2_k127_6693561_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 2.248e-207 667.0
SHD2_k127_6693561_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K07106 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009254,GO:0016787,GO:0016801,GO:0016803,GO:0016829,GO:0016835,GO:0030203,GO:0043170,GO:0046348,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901575 4.2.1.126 0.000000000000000000000000000004574 123.0
SHD2_k127_6693561_2 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.0000000000000000000001194 103.0
SHD2_k127_6693561_3 - - - - 0.0008138 45.0
SHD2_k127_6706678_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 440.0
SHD2_k127_6706678_1 Belongs to the 5'-nucleotidase family K01081,K11751 - 3.1.3.5,3.6.1.45 0.000000000000979 77.0
SHD2_k127_6709961_0 AIR synthase related protein, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007213 481.0
SHD2_k127_6709961_1 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 372.0
SHD2_k127_6709961_2 transcription activator K03707 - 3.5.99.2 0.0000000000000000000000000000000000000000000000000000001228 204.0
SHD2_k127_6709961_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0004079 51.0
SHD2_k127_6715218_0 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 428.0
SHD2_k127_6715218_1 Sterol carrier protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 351.0
SHD2_k127_6715218_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000002766 231.0
SHD2_k127_6715218_3 COGs COG1392 Phosphate transport regulator (distant homolog of PhoU) K07220 - - 0.000000000000000000000000000000000000000002055 163.0
SHD2_k127_6715218_4 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000001864 105.0
SHD2_k127_6715218_5 4Fe-4S dicluster domain - - - 0.000000000000000000003466 95.0
SHD2_k127_6715218_6 O-linked GlcNAc transferase-putative TPR-containing transmembrane protein - - - 0.00000000000000007695 95.0
SHD2_k127_6715218_7 protein heterodimerization activity - - - 0.0000000000000004271 81.0
SHD2_k127_6715218_8 Tetratricopeptide repeat - - - 0.00000006564 66.0
SHD2_k127_6728250_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 354.0
SHD2_k127_6728250_1 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001113 284.0
SHD2_k127_6728250_2 Quinol cytochrome C oxidoreductase - - - 0.0000000000000000000000177 104.0
SHD2_k127_6744406_0 Metalloenzyme superfamily K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 419.0
SHD2_k127_6744406_1 Glycosyl transferase, family 2 - - - 0.000000000000000001972 93.0
SHD2_k127_6744406_2 mercuric transport protein - - - 0.0000004091 61.0
SHD2_k127_6744406_3 N-Acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000007625 51.0
SHD2_k127_6779444_0 PFAM PQQ enzyme repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 305.0
SHD2_k127_6779444_1 glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000169 246.0
SHD2_k127_6779444_2 glycosyl transferase group 1 - - - 0.0000000000181 74.0
SHD2_k127_6783662_0 Binding-protein-dependent transport system inner membrane component K02050 - - 8.459e-230 725.0
SHD2_k127_6783662_1 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 604.0
SHD2_k127_6788577_0 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006976 309.0
SHD2_k127_6788577_1 GTP cyclohydrolase I K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000003889 243.0
SHD2_k127_6788577_2 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000004375 229.0
SHD2_k127_6788577_3 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000011 82.0
SHD2_k127_6788577_4 Tetratricopeptide repeat - - - 0.000000009624 66.0
SHD2_k127_6807128_0 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 335.0
SHD2_k127_6825214_0 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 522.0
SHD2_k127_6825214_1 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000002249 84.0
SHD2_k127_6830795_0 C-terminal AAA-associated domain K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 552.0
SHD2_k127_6830795_1 permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001947 266.0
SHD2_k127_6830795_2 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000002164 89.0
SHD2_k127_6833210_0 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 489.0
SHD2_k127_6833210_1 Pyruvate ferredoxin oxidoreductase and related K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 490.0
SHD2_k127_6833210_10 BMC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006504 269.0
SHD2_k127_6833210_11 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001975 235.0
SHD2_k127_6833210_12 Metallo-beta-lactamase superfamily K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000003958 229.0
SHD2_k127_6833210_13 Histidine kinase A domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000007576 222.0
SHD2_k127_6833210_14 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000003549 196.0
SHD2_k127_6833210_15 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503 - - 0.0000000000000000000000000000000000000000000001318 170.0
SHD2_k127_6833210_16 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03388 - 1.6.5.3,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000001763 171.0
SHD2_k127_6833210_17 BNR repeat-like domain - - - 0.00000000000000000000002243 116.0
SHD2_k127_6833210_18 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000002047 74.0
SHD2_k127_6833210_19 TIGRFAM regulatory protein, FmdB - - - 0.000002469 60.0
SHD2_k127_6833210_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 395.0
SHD2_k127_6833210_3 Sodium/calcium exchanger protein K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 387.0
SHD2_k127_6833210_4 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 401.0
SHD2_k127_6833210_5 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 351.0
SHD2_k127_6833210_6 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 340.0
SHD2_k127_6833210_7 Heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002365 328.0
SHD2_k127_6833210_8 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 313.0
SHD2_k127_6833210_9 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002983 295.0
SHD2_k127_6852118_0 Carbamoyltransferase C-terminus K00612 - - 7.59e-295 914.0
SHD2_k127_6852118_1 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 532.0
SHD2_k127_6852118_10 Putative regulatory protein - - - 0.0000000000000000000000132 102.0
SHD2_k127_6852118_11 - - - - 0.000000000009593 68.0
SHD2_k127_6852118_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000002075 66.0
SHD2_k127_6852118_13 PFAM glutamate synthase alpha subunit - - - 0.00002712 57.0
SHD2_k127_6852118_15 Armadillo/beta-catenin-like repeats - - - 0.00007341 54.0
SHD2_k127_6852118_16 Peptidase, M28 - - - 0.0008835 45.0
SHD2_k127_6852118_2 Type II restriction enzyme K01155 - 3.1.21.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 514.0
SHD2_k127_6852118_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 370.0
SHD2_k127_6852118_4 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000385 229.0
SHD2_k127_6852118_5 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000006759 218.0
SHD2_k127_6852118_6 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000007124 179.0
SHD2_k127_6852118_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000001083 181.0
SHD2_k127_6852118_8 Pfam:Methyltransf_26 K08316 - 2.1.1.171 0.00000000000000000000000000000000000002748 150.0
SHD2_k127_6852118_9 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000418 132.0
SHD2_k127_6880567_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1049.0
SHD2_k127_6880567_1 PFAM Pyridoxal-dependent decarboxylase K01580 - 4.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 576.0
SHD2_k127_6880567_2 O-methyltransferase family 3 - - - 0.000000000000000000000000000000000000000000000000000000000000002113 222.0
SHD2_k127_6880567_3 Uncharacterised ArCR, COG2043 - - - 0.0000000000000000000000000000000000000000000000000000000000001032 220.0
SHD2_k127_6884663_0 M42 glutamyl aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 356.0
SHD2_k127_6884663_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 363.0
SHD2_k127_6884663_2 domain protein K01179,K02238,K20276 - 3.2.1.4 0.000000000000000000000000000000000000000001589 176.0
SHD2_k127_689743_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1187.0
SHD2_k127_689743_1 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002215 279.0
SHD2_k127_689743_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000006689 180.0
SHD2_k127_689743_3 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.0006003 48.0
SHD2_k127_6905438_0 MMPL family - - - 1.214e-308 981.0
SHD2_k127_6905438_1 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000282 249.0
SHD2_k127_6905438_2 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000006771 183.0
SHD2_k127_6913272_0 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 533.0
SHD2_k127_6913272_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 425.0
SHD2_k127_6913272_2 Peptidase family C25 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 357.0
SHD2_k127_6913272_3 Peptidase family M20/M25/M40 K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 312.0
SHD2_k127_6913272_4 Polysaccharide export protein K01991,K20988 - - 0.000000000000000000000000000000002113 142.0
SHD2_k127_6913272_5 protein involved in exopolysaccharide biosynthesis K16554,K16692 - - 0.00000000000000006083 95.0
SHD2_k127_6913272_6 Psort location OuterMembrane, score - - - 0.0000000001151 72.0
SHD2_k127_6913272_7 amino acid activation for nonribosomal peptide biosynthetic process K01183 - 3.2.1.14 0.000000001924 72.0
SHD2_k127_6924732_0 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006478 249.0
SHD2_k127_6924732_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000003776 158.0
SHD2_k127_6924732_2 Two component transcriptional regulator, winged helix family K02483 - - 0.000000000000000000000000002366 114.0
SHD2_k127_6948120_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 457.0
SHD2_k127_6948120_1 NmrA-like family K15891 - 1.1.1.354 0.00000000000000000000000000000000000000000000000000000003101 209.0
SHD2_k127_6948120_2 Yip1 domain - - - 0.0001739 50.0
SHD2_k127_6982813_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 405.0
SHD2_k127_6982813_1 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001452 235.0
SHD2_k127_6982813_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000003385 194.0
SHD2_k127_6982813_3 Por secretion system C-terminal sorting domain-containing protein - - - 0.0000000000000000000000000000000000000000000000000002299 194.0
SHD2_k127_6982813_4 RNA recognition motif - - - 0.000000000000000000000000000001574 123.0
SHD2_k127_6982813_5 RNA recognition motif - - - 0.000000000000000004523 91.0
SHD2_k127_6995865_0 Molydopterin dinucleotide binding domain K17050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 488.0
SHD2_k127_6995865_1 4Fe-4S dicluster domain K16965 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 327.0
SHD2_k127_6995865_2 4Fe-4S dicluster domain K00371,K17051 - 1.7.5.1 0.0000000000000000000006281 102.0
SHD2_k127_6995865_3 Nitrate reductase delta subunit - - - 0.000000005 67.0
SHD2_k127_6995865_4 Ethylbenzene dehydrogenase - - - 0.000002044 59.0
SHD2_k127_7009124_0 PFAM sigma-54 factor interaction domain-containing protein K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 417.0
SHD2_k127_7009124_1 Histidine kinase - - - 0.0000000000000000000000000000000000000002156 155.0
SHD2_k127_7023318_0 DNA polymerase K02337,K14162 - 2.7.7.7 4.993e-206 683.0
SHD2_k127_7023318_1 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 490.0
SHD2_k127_7023318_2 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007063 483.0
SHD2_k127_7023318_3 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 378.0
SHD2_k127_7023318_4 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000001198 201.0
SHD2_k127_7023318_5 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000006225 197.0
SHD2_k127_7023318_6 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000002034 186.0
SHD2_k127_7023318_7 IMS family HHH motif K02346 - 2.7.7.7 0.00000000000000000000000000000000000003102 156.0
SHD2_k127_7023318_8 IMS family HHH motif K02346 - 2.7.7.7 0.00000000000000000000003037 109.0
SHD2_k127_7030056_0 DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 570.0
SHD2_k127_7030056_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000001655 90.0
SHD2_k127_707498_0 Fumarate reductase flavoprotein C-term K00239,K00244 - 1.3.5.1,1.3.5.4 2.175e-266 832.0
SHD2_k127_707498_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 422.0
SHD2_k127_707498_2 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 341.0
SHD2_k127_707498_3 FAD binding domain K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 325.0
SHD2_k127_707498_4 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain - - - 0.00000000000000000000000000000000000000000000008151 171.0
SHD2_k127_707498_5 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000001301 156.0
SHD2_k127_707498_6 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000001165 110.0
SHD2_k127_707498_7 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000000004015 105.0
SHD2_k127_707498_8 nucleotidyltransferase activity K17882 - - 0.0000003422 58.0
SHD2_k127_7075551_0 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K20444 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000008676 218.0
SHD2_k127_7075551_1 Belongs to the metal hydrolase YfiT family - - - 0.00000000000000000000000000000000000000000000000000000000001069 211.0
SHD2_k127_7075551_2 - - - - 0.0000000000000000000000000000000000000000000000001095 185.0
SHD2_k127_7075551_3 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000001067 178.0
SHD2_k127_7075551_4 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000004923 171.0
SHD2_k127_7075551_5 Low affinity iron permease - - - 0.0000000000000000000000000000000000000000000005697 172.0
SHD2_k127_7075813_0 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 337.0
SHD2_k127_7075813_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008277 287.0
SHD2_k127_7075813_2 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003293 277.0
SHD2_k127_7075813_3 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000005547 153.0
SHD2_k127_7075813_4 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K16786 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 - 0.0000000000000000001803 103.0
SHD2_k127_7077594_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008205 528.0
SHD2_k127_7077594_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007772 462.0
SHD2_k127_7077594_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 339.0
SHD2_k127_7077594_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000006197 275.0
SHD2_k127_7077594_4 Stage V sporulation protein E K03588 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000001158 254.0
SHD2_k127_7077594_5 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000008589 59.0
SHD2_k127_7077594_6 Cell division protein FtsQ K03589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0071944 - 0.000000938 57.0
SHD2_k127_7108824_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006341 434.0
SHD2_k127_7108824_1 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 359.0
SHD2_k127_7108824_2 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000004376 203.0
SHD2_k127_7108824_3 - - - - 0.00000000000000000000000000000000001836 142.0
SHD2_k127_7108824_4 Cro/C1-type HTH DNA-binding domain K07729 - - 0.00000000000001726 75.0
SHD2_k127_7108824_5 translation initiation factor activity K03699 - - 0.0000000000005869 78.0
SHD2_k127_7108824_6 domain protein - - - 0.0000000003016 65.0
SHD2_k127_7119193_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 8.116e-297 935.0
SHD2_k127_7119193_1 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006684 441.0
SHD2_k127_7119193_2 Polysaccharide biosynthesis protein K12454 - 5.1.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004372 370.0
SHD2_k127_7119193_3 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000003276 267.0
SHD2_k127_7119193_4 Nitrogen fixation master sensor histidine kinase, PAS domain-containing K02668,K07708,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000002404 222.0
SHD2_k127_7119193_5 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000001653 150.0
SHD2_k127_7119193_6 Lipopolysaccharide-assembly - - - 0.00000000008497 70.0
SHD2_k127_7119193_7 DNA-directed DNA polymerase activity K02340 - 2.7.7.7 0.000000002238 70.0
SHD2_k127_7127517_0 Belongs to the serpin family K13963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006339 287.0
SHD2_k127_7127517_1 Belongs to the serpin family K13963 - - 0.00000000000000000000000000000000000000000000000000003184 197.0
SHD2_k127_7127517_2 Glycosyl Transferase - - - 0.0000000008652 61.0
SHD2_k127_7127517_3 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000868 53.0
SHD2_k127_7127517_4 Serine (or cysteine) peptidase inhibitor, clade F, member 1 K19614 GO:0003008,GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005604,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0007275,GO:0007399,GO:0007610,GO:0007611,GO:0007613,GO:0007614,GO:0008150,GO:0008283,GO:0008285,GO:0009892,GO:0009987,GO:0010466,GO:0010468,GO:0010594,GO:0010596,GO:0010605,GO:0010629,GO:0010632,GO:0010633,GO:0010720,GO:0010941,GO:0010951,GO:0010975,GO:0010976,GO:0016525,GO:0019222,GO:0022008,GO:0022603,GO:0030154,GO:0030162,GO:0030234,GO:0030334,GO:0030336,GO:0030414,GO:0030424,GO:0031012,GO:0031323,GO:0031324,GO:0031344,GO:0031346,GO:0031347,GO:0031348,GO:0032101,GO:0032102,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032879,GO:0033267,GO:0036477,GO:0040012,GO:0040013,GO:0042127,GO:0042995,GO:0043005,GO:0043025,GO:0043086,GO:0043203,GO:0044092,GO:0044297,GO:0044421,GO:0044424,GO:0044444,GO:0044463,GO:0044464,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045765,GO:0045861,GO:0048471,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050678,GO:0050680,GO:0050727,GO:0050728,GO:0050767,GO:0050769,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050877,GO:0050890,GO:0051093,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051248,GO:0051270,GO:0051271,GO:0051336,GO:0051346,GO:0051960,GO:0051962,GO:0052547,GO:0052548,GO:0060255,GO:0060284,GO:0060548,GO:0060768,GO:0060770,GO:0061134,GO:0061135,GO:0062023,GO:0065007,GO:0065009,GO:0080090,GO:0080134,GO:0097458,GO:0098772,GO:0120025,GO:0120035,GO:0120038,GO:1901214,GO:1901215,GO:1901342,GO:1901343,GO:2000026,GO:2000145,GO:2000146,GO:2000181,GO:2000241,GO:2000242 - 0.000316 44.0
SHD2_k127_7132573_0 Amidohydrolase family K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 603.0
SHD2_k127_7132573_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 587.0
SHD2_k127_7132573_2 Carbon-nitrogen hydrolase K01431,K12251 - 3.5.1.53,3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 503.0
SHD2_k127_7132573_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K17722 - 1.3.1.1 0.00000000000000000000000000000000000000000000007019 173.0
SHD2_k127_7155981_0 Dehydrogenase E1 component K11381 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 392.0
SHD2_k127_7155981_1 LytB protein K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 313.0
SHD2_k127_7155981_2 - - - - 0.0000000000000000000000000000000000000001659 166.0
SHD2_k127_7156006_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 323.0
SHD2_k127_7156006_1 response to pH - - - 0.00000000000000000000000000000000000000000000000000007192 193.0
SHD2_k127_7156006_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000006727 106.0
SHD2_k127_7156006_3 - - - - 0.0003659 50.0
SHD2_k127_7166070_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 1.783e-215 687.0
SHD2_k127_7166070_1 Proton-conducting membrane transporter K00342 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005345 584.0
SHD2_k127_7166070_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.00000000000000000000000000000000000000000000000000000000000000000007439 239.0
SHD2_k127_7166070_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000000001207 160.0
SHD2_k127_7166070_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000002099 140.0
SHD2_k127_7166070_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000001971 88.0
SHD2_k127_7207772_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.327e-208 673.0
SHD2_k127_7207772_1 Participates in both transcription termination and antitermination K02600 GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005938 440.0
SHD2_k127_7207772_2 Peptidase M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002876 248.0
SHD2_k127_7207772_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000006956 232.0
SHD2_k127_7207772_4 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000007899 141.0
SHD2_k127_7207772_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000326 108.0
SHD2_k127_7207772_6 Protein of unknown function (DUF503) K09764 - - 0.000000000008595 78.0
SHD2_k127_7207781_0 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 350.0
SHD2_k127_7207781_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 308.0
SHD2_k127_7207781_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000141 250.0
SHD2_k127_7207781_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000002068 200.0
SHD2_k127_7207781_4 Bacterial Ig-like domain - - - 0.000001588 60.0
SHD2_k127_7229171_0 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000003314 258.0
SHD2_k127_7229171_1 - - - - 0.0000000000000000000000000000000000000000000000000000005642 214.0
SHD2_k127_7229171_3 Evidence 5 No homology to any previously reported sequences - - - 0.00000000008304 68.0
SHD2_k127_7229171_4 SPTR Peptidase S8 and S53 subtilisin kexin sedolisin K14645,K17713,K20952 - - 0.0005219 53.0
SHD2_k127_7278822_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 431.0
SHD2_k127_7278822_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 361.0
SHD2_k127_7278822_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000002109 148.0
SHD2_k127_7278822_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.0000000000000000000000000000005867 123.0
SHD2_k127_7278822_4 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.0000000000000000000000001716 112.0
SHD2_k127_7278822_5 Protein of unknown function (DUF2905) - - - 0.00000000000004479 74.0
SHD2_k127_7278822_6 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000005811 68.0
SHD2_k127_7285324_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 376.0
SHD2_k127_7285324_1 Carbon dioxide concentrating mechanism carboxysome shell protein - - - 0.000000000000000000000000000000000008802 143.0
SHD2_k127_7285324_2 PFAM GCN5-related N-acetyltransferase K00657 - 2.3.1.57 0.0000000000000000000116 103.0
SHD2_k127_7285324_3 Ethanolamine utilisation protein EutN/carboxysome - - - 0.0000000000000004687 80.0
SHD2_k127_7305654_0 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000000001717 88.0
SHD2_k127_7348718_0 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000316 640.0
SHD2_k127_7348718_1 Fic/DOC family K07341 - - 0.0000000000000000000000000000000004376 138.0
SHD2_k127_7348718_2 PFAM SpoVT AbrB K07172,K18842 - - 0.0000000000002651 72.0
SHD2_k127_7348718_3 Mur ligase middle domain K01932 - - 0.0000000003092 62.0
SHD2_k127_7368051_0 flagellar basal body FlaE domain protein K02390 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 315.0
SHD2_k127_7368051_1 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001273 256.0
SHD2_k127_7368051_2 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.00000000000000000000000000000000000000000000000000000002521 219.0
SHD2_k127_7368051_3 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000000000000000000000000008642 121.0
SHD2_k127_7368051_4 Flagellar motor switch protein FliM K02416 - - 0.00000000000000000000007987 111.0
SHD2_k127_7368051_5 Type III flagellar switch regulator (C-ring) FliN C-term K02417 - - 0.0000000000000000001015 100.0
SHD2_k127_7368051_6 Role in flagellar biosynthesis K02420 - - 0.00000000000005213 74.0
SHD2_k127_7368051_7 Flagellar biosynthetic protein FliR K02421 - - 0.0000000000007948 79.0
SHD2_k127_7368051_8 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.0000000003446 69.0
SHD2_k127_7368051_9 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.0002392 48.0
SHD2_k127_7394672_0 Cytochrome bd-type quinol oxidase subunit 1 K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 522.0
SHD2_k127_7394672_1 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000002522 247.0
SHD2_k127_7394672_2 Cytochrome bd-type quinol oxidase, subunit 2 K00426 - 1.10.3.14 0.0000000006833 62.0
SHD2_k127_7398820_0 synthase K00705,K06044 GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 4.627e-305 967.0
SHD2_k127_7398820_1 SMART Elongator protein 3 MiaB NifB - - - 1.668e-207 677.0
SHD2_k127_7398820_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 296.0
SHD2_k127_7398820_3 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000001087 208.0
SHD2_k127_7398820_4 succinate dehydrogenase K00241 - - 0.000000000000000000000000000000002116 142.0
SHD2_k127_7398820_5 ABC transporter substrate-binding protein K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0042597,GO:0043167,GO:0043168,GO:0044464 - 0.00000000000000000000000000000006543 134.0
SHD2_k127_7398820_6 cheY-homologous receiver domain - - - 0.00000000000000000000000000003027 124.0
SHD2_k127_7399923_0 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 467.0
SHD2_k127_7399923_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000888 81.0
SHD2_k127_7399923_2 PFAM Bacterial regulatory proteins, gntR family K07979 - - 0.00000000001941 66.0
SHD2_k127_7399923_3 O-Antigen ligase K18814 - - 0.000000001193 70.0
SHD2_k127_7414679_0 High confidence in function and specificity - - - 9.073e-215 688.0
SHD2_k127_7414679_1 PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000005577 244.0
SHD2_k127_7414679_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000159 122.0
SHD2_k127_7414679_3 CsbD-like - - - 0.00000000000000000000003598 102.0
SHD2_k127_7416070_0 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000003517 241.0
SHD2_k127_7416070_1 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000365 198.0
SHD2_k127_7417423_0 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000001395 211.0
SHD2_k127_7417423_1 periplasmic or secreted lipoprotein - - - 0.00000000000000000000000002534 122.0
SHD2_k127_7417423_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000001128 73.0
SHD2_k127_7431018_0 asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 327.0
SHD2_k127_7431018_1 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007263 293.0
SHD2_k127_7431018_3 Metallo-beta-lactamase domain protein K06167 - 3.1.4.55 0.000000000000000004156 94.0
SHD2_k127_7431018_4 - - - - 0.0000002005 59.0
SHD2_k127_7447542_0 ABC transporter, transmembrane K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 476.0
SHD2_k127_7447542_1 serine-type endopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002903 253.0
SHD2_k127_7447542_2 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000004782 205.0
SHD2_k127_7447542_3 COG3119 Arylsulfatase A and related enzymes K01130 - 3.1.6.1 0.000000000000000000000000000000000000000000002035 182.0
SHD2_k127_7447542_4 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000001862 167.0
SHD2_k127_7447542_5 cell redox homeostasis K03671 - - 0.000000000000008839 85.0
SHD2_k127_7447542_6 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00003383 49.0
SHD2_k127_7447542_7 Thiol-disulfide isomerase and thioredoxins - - - 0.00008754 53.0
SHD2_k127_7516246_0 peptidase activity, acting on L-amino acid peptides K01337,K05994,K20276 - 3.4.11.10,3.4.21.50 0.000000000000000000000000000000000000000000000000000000002086 226.0
SHD2_k127_7516246_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000005975 151.0
SHD2_k127_7516246_2 PFAM flagellar FlbT family protein K06601 - - 0.0000000000000000000000000002391 122.0
SHD2_k127_7516246_3 PFAM flagellar FlaF family protein K06602 - - 0.0000000000000000000000004361 108.0
SHD2_k127_7516246_4 response regulator receiver K03413 - - 0.0000000000000000000006401 101.0
SHD2_k127_7516246_5 - - - - 0.00000000000000004885 85.0
SHD2_k127_7516246_6 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - 0.000000000009721 65.0
SHD2_k127_7522752_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 372.0
SHD2_k127_7522752_1 DinB family - - - 0.00000000000000000000000000000000000000001202 161.0
SHD2_k127_7522752_2 - - - - 0.0000000000000000000000000000000000009987 142.0
SHD2_k127_7522752_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000009959 67.0
SHD2_k127_7525935_0 4Fe-4S dicluster domain K17723 - 1.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000094 617.0
SHD2_k127_7525935_1 ATP:ADP antiporter activity K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 533.0
SHD2_k127_7525935_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K17722 - 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000008758 215.0
SHD2_k127_7525935_3 - - - - 0.0000000000000000000000000000000000000000000000000000004377 217.0
SHD2_k127_7525935_4 ATP ADP translocase K03301 - - 0.000000000000000000000000000000000000002187 155.0
SHD2_k127_7525935_5 cyclic nucleotide binding K00384,K10914,K16922 - 1.8.1.9 0.0000000000000000000000000000000000005655 156.0
SHD2_k127_7525935_6 acid phosphatase activity K22390 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000001039 81.0
SHD2_k127_7525935_7 Surface antigen - - - 0.0004306 53.0
SHD2_k127_7525935_8 - - - - 0.0008285 47.0
SHD2_k127_7534277_0 Glycosyltransferase 36 associated - - - 2.718e-287 908.0
SHD2_k127_7534277_1 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 525.0
SHD2_k127_7534277_2 regulation of microtubule-based process K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 418.0
SHD2_k127_7534277_3 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0000000000000000000000000000000000000000000000000000003338 210.0
SHD2_k127_7534277_4 regulation of translation K03530 - - 0.00000000000000000000000000004406 120.0
SHD2_k127_7534277_5 acid phosphatase activity K07498 - - 0.00000000000000000000005066 113.0
SHD2_k127_7534277_6 - - - - 0.000000000002811 77.0
SHD2_k127_7534277_7 Belongs to the glycosyl hydrolase 1 family K05350 - 3.2.1.21 0.0000003161 54.0
SHD2_k127_7536838_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 450.0
SHD2_k127_7536838_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 303.0
SHD2_k127_7536838_2 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001725 282.0
SHD2_k127_7536838_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000001125 254.0
SHD2_k127_7551973_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003433 268.0
SHD2_k127_7551973_1 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000008777 106.0
SHD2_k127_7551973_2 PFAM Single-stranded nucleic acid binding R3H K06346 - - 0.000000000000000000001692 99.0
SHD2_k127_7551973_3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000000000003111 83.0
SHD2_k127_7551973_4 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000001102 68.0
SHD2_k127_7564237_0 COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K12528 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 462.0
SHD2_k127_7564237_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 454.0
SHD2_k127_7564237_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 455.0
SHD2_k127_7564237_3 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000009015 245.0
SHD2_k127_7564237_5 CbiX - - - 0.0000000000000000000000003961 120.0
SHD2_k127_7564237_6 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.00000004946 55.0
SHD2_k127_7564237_7 - - - - 0.0000001392 59.0
SHD2_k127_7564237_8 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000002391 60.0
SHD2_k127_7585453_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 550.0
SHD2_k127_7585453_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 418.0
SHD2_k127_7585453_2 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000004239 151.0
SHD2_k127_7595051_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 4.614e-219 702.0
SHD2_k127_7595051_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.000000000000000000000000000000000000000000000006413 181.0
SHD2_k127_7596773_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000001265 63.0
SHD2_k127_7649023_0 Amino-transferase class IV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 366.0
SHD2_k127_7649023_1 PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001735 265.0
SHD2_k127_7654845_0 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 336.0
SHD2_k127_7654845_1 PFAM MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000002376 152.0
SHD2_k127_7654845_2 PFAM OmpA MotB domain protein K03640 - - 0.00000000000000000000000000000000001811 143.0
SHD2_k127_7654845_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000002329 121.0
SHD2_k127_7654845_4 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000000000000000101 118.0
SHD2_k127_7654845_5 energy transducer activity K03646,K03832 - - 0.00000000000001576 83.0
SHD2_k127_7654845_6 Transcriptional regulatory protein, C terminal K07658 - - 0.0001011 44.0
SHD2_k127_7656228_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 468.0
SHD2_k127_7656228_1 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 370.0
SHD2_k127_7656228_2 iron-sulfur cluster assembly K07400 - - 0.000000000000000000000000000000000000002635 154.0
SHD2_k127_7681847_0 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000009868 189.0
SHD2_k127_7681847_1 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000003296 170.0
SHD2_k127_7681847_2 Sigma-70 region 2 K03088 - - 0.000000000000000000000000003666 114.0
SHD2_k127_7681847_3 - - - - 0.00000000000000000000000001168 118.0
SHD2_k127_7681847_4 - - - - 0.0000000000000000000003194 109.0
SHD2_k127_7681847_5 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000009002 79.0
SHD2_k127_7685779_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 3.537e-261 824.0
SHD2_k127_7685779_1 Belongs to the peptidase M16 family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 367.0
SHD2_k127_7685779_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 299.0
SHD2_k127_7685779_3 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000001241 253.0
SHD2_k127_7685779_4 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000001562 170.0
SHD2_k127_7685779_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000007456 128.0
SHD2_k127_7685779_6 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000001012 119.0
SHD2_k127_7685779_7 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000001755 93.0
SHD2_k127_7685779_8 Protein of unknown function (DUF3108) - - - 0.00000000000000984 84.0
SHD2_k127_7687957_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 411.0
SHD2_k127_7687957_1 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 386.0
SHD2_k127_7687957_2 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 310.0
SHD2_k127_7687957_3 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000001135 218.0
SHD2_k127_7690058_0 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000004383 250.0
SHD2_k127_7690058_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000002047 154.0
SHD2_k127_7690058_2 Tryptophan synthase alpha chain K01695 - 4.2.1.20 0.00000000000000000000000000002185 123.0
SHD2_k127_7690058_3 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.000000001171 66.0
SHD2_k127_769102_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 3.469e-310 966.0
SHD2_k127_769102_1 Peptidase family M13 K07386 - - 4.106e-229 729.0
SHD2_k127_769102_2 ROK family K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 404.0
SHD2_k127_769102_3 homocysteine catabolic process K01372,K02316 - 3.4.22.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 377.0
SHD2_k127_769102_4 Poly-gamma-glutamate hydrolase - - - 0.0000000000000000000000000000000000007781 147.0
SHD2_k127_769102_5 - - - - 0.000000000000008802 83.0
SHD2_k127_7753298_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 432.0
SHD2_k127_7753298_1 Two component transcriptional regulator, winged helix family K07658,K07668 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001792 253.0
SHD2_k127_7753298_2 phosphorelay sensor kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000003387 248.0
SHD2_k127_7753298_3 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000001425 226.0
SHD2_k127_7753298_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07636 - 2.7.13.3 0.00000000000000000000007093 106.0
SHD2_k127_7753298_5 Extracellular solute-binding protein K02035 - - 0.0000001085 65.0
SHD2_k127_7753298_6 Integrin alpha (beta-propellor repeats). - - - 0.00004578 55.0
SHD2_k127_7761996_0 The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation K16899 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 514.0
SHD2_k127_7761996_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000116 230.0
SHD2_k127_777433_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 458.0
SHD2_k127_777433_1 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000003217 262.0
SHD2_k127_777433_2 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000006218 238.0
SHD2_k127_777433_3 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.000000000000000000000000000000000000000000000000000001173 204.0
SHD2_k127_777433_4 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.0000000007456 71.0
SHD2_k127_7784033_0 Bacterial regulatory protein, Fis family K02584 - - 0.000000000000000000000000000000000000000002374 178.0
SHD2_k127_7786482_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 308.0
SHD2_k127_7786482_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000002918 201.0
SHD2_k127_7786482_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.00000000000000000000000000000000000000001121 159.0
SHD2_k127_7787057_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 520.0
SHD2_k127_7787057_1 GDP-mannose 4,6 dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 475.0
SHD2_k127_7787057_10 phosphoprotein phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000007918 208.0
SHD2_k127_7787057_11 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000000000000007812 193.0
SHD2_k127_7787057_12 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000002368 173.0
SHD2_k127_7787057_13 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000001202 117.0
SHD2_k127_7787057_2 Protein of unknown function (DUF2723) K16928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 410.0
SHD2_k127_7787057_3 Polysaccharide biosynthesis protein K01784,K08679 - 5.1.3.2,5.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 364.0
SHD2_k127_7787057_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 346.0
SHD2_k127_7787057_5 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 323.0
SHD2_k127_7787057_6 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 317.0
SHD2_k127_7787057_7 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005456 312.0
SHD2_k127_7787057_8 Glycosyltransferase like family 2 K03606,K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005586 302.0
SHD2_k127_7787057_9 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000002353 228.0
SHD2_k127_7809631_0 Nickel-dependent hydrogenase K14126 - 1.8.98.5 1.481e-237 742.0
SHD2_k127_7809631_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008374 346.0
SHD2_k127_7814236_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 3.107e-202 640.0
SHD2_k127_7814236_1 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005077 296.0
SHD2_k127_7814236_2 Male sterility protein - - - 0.0000000000000000000000000000000000000000000001745 183.0
SHD2_k127_7814236_3 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000000005433 117.0
SHD2_k127_7814236_4 PFAM glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000006968 123.0
SHD2_k127_7814236_5 polysaccharide biosynthetic process - - - 0.000000000000000008786 97.0
SHD2_k127_7814236_6 Glycosyl transferase family 2 K07011 - - 0.000000000000001762 81.0
SHD2_k127_7814236_7 response regulator - - - 0.000000000000004743 89.0
SHD2_k127_7814236_8 transferase activity, transferring glycosyl groups - - - 0.0000991 54.0
SHD2_k127_7832020_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 311.0
SHD2_k127_7832020_1 Evidence 5 No homology to any previously reported sequences - - - 0.000000000000000000000000001956 130.0
SHD2_k127_7832020_2 Domain of unknown function (DUF2341) - - - 0.00000000000000000925 99.0
SHD2_k127_7832020_3 BNR repeat-like domain - - - 0.000000000000001336 92.0
SHD2_k127_7832020_4 COG3209 Rhs family protein - - - 0.00000000000002974 86.0
SHD2_k127_7832020_5 NHL repeat - - - 0.0000003754 61.0
SHD2_k127_7844808_0 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000233 243.0
SHD2_k127_7844808_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000002029 169.0
SHD2_k127_7844808_2 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000002554 108.0
SHD2_k127_7844808_3 Phosphoribosyl transferase domain - - - 0.00000000000000000001414 101.0
SHD2_k127_7889230_0 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 413.0
SHD2_k127_7889230_1 Hexapeptide repeat of succinyl-transferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 304.0
SHD2_k127_7889230_2 PFAM Uncharacterised protein family (UPF0164) - - - 0.000000000000000000000003655 117.0
SHD2_k127_7889230_3 Oxidoreductase family, NAD-binding Rossmann fold K13018 - 2.3.1.201 0.0000000000000002073 80.0
SHD2_k127_79000_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 6.096e-196 631.0
SHD2_k127_79000_1 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000001385 231.0
SHD2_k127_79000_2 Domain of unknown function (DUF305) - - - 0.000000000000000000000001775 110.0
SHD2_k127_7906492_0 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 371.0
SHD2_k127_7906492_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000001381 204.0
SHD2_k127_7906492_2 - - - - 0.000000000001045 80.0
SHD2_k127_7913548_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 368.0
SHD2_k127_7913548_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001181 197.0
SHD2_k127_7913548_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000001348 139.0
SHD2_k127_7913548_3 Could be involved in septation K06412 - - 0.00000000000000000000000002453 110.0
SHD2_k127_7913548_4 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000001102 58.0
SHD2_k127_7916268_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 621.0
SHD2_k127_7916268_1 oligosaccharyl transferase activity - - - 0.000000000000000000000186 105.0
SHD2_k127_7916268_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000125 64.0
SHD2_k127_7919488_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1392.0
SHD2_k127_7919488_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.551e-317 986.0
SHD2_k127_7919488_2 PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000003697 259.0
SHD2_k127_7919488_3 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.00000000000000000000000000000000002224 136.0
SHD2_k127_7919784_0 Peptidase family M41 K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 617.0
SHD2_k127_7919784_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760,K00939,K15780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,2.7.4.3,6.3.4.19 0.000000001871 59.0
SHD2_k127_7926072_0 coagulation factor 5 8 type - - - 2.647e-264 854.0
SHD2_k127_7926072_1 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 564.0
SHD2_k127_7948270_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006715 425.0
SHD2_k127_7948270_1 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002156 277.0
SHD2_k127_7948270_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007982 278.0
SHD2_k127_7948270_3 SecD/SecF GG Motif K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001456 252.0
SHD2_k127_7948270_4 DNA recombination - - - 0.00000006776 64.0
SHD2_k127_7948270_5 Divergent polysaccharide deacetylase K09798 - - 0.0000817 47.0
SHD2_k127_7961554_0 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002308 258.0
SHD2_k127_7984279_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 3.179e-248 777.0
SHD2_k127_7984279_1 Heme copper-type cytochrome quinol oxidase, subunit K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003743 276.0
SHD2_k127_7984279_2 PSP1 C-terminal conserved region - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000001366 252.0
SHD2_k127_7984279_3 TIGRFAM hydrolase, TatD family K03424 - - 0.0000000000000000000000000000000000000000000000000000000001528 217.0
SHD2_k127_7984279_4 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000000000000001227 210.0
SHD2_k127_7984279_5 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000001314 196.0
SHD2_k127_7984279_6 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000001805 182.0
SHD2_k127_7984279_7 Cytochrome oxidase assembly protein K02259,K03110 - - 0.00000000000000000000000000000000000352 154.0
SHD2_k127_7984279_8 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000000000000000003328 103.0
SHD2_k127_7984279_9 cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000001418 108.0
SHD2_k127_7991283_0 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 2.834e-269 845.0
SHD2_k127_7991283_1 DinB family - - - 0.000000000000000000000000000000000000000000000007861 177.0
SHD2_k127_7991283_2 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000004486 170.0
SHD2_k127_7991283_3 DinB family - - - 0.0000000000000000000000000000000000000000002261 164.0
SHD2_k127_7991283_4 Thioredoxin domain - - - 0.000000000000000000000000000000000000000003408 161.0
SHD2_k127_7991283_5 OsmC-like protein - - - 0.000000000000000000000000000000003291 134.0
SHD2_k127_7991283_6 methyltransferase activity K00587 - 2.1.1.100 0.0000000000000000000000000006242 121.0
SHD2_k127_7991283_7 alkyl hydroperoxide reductase activity - - - 0.00000000000000000000001408 101.0
SHD2_k127_7991283_8 PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily K06996 - - 0.000000000000000009431 89.0
SHD2_k127_7998060_0 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 374.0
SHD2_k127_7998060_1 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 348.0
SHD2_k127_7998060_2 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004805 265.0
SHD2_k127_7998060_3 Evidence 5 No homology to any previously reported sequences - - - 0.00001681 48.0
SHD2_k127_8004544_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 331.0
SHD2_k127_8004544_1 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 323.0
SHD2_k127_8004544_2 unfolded protein binding K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000000000002 167.0
SHD2_k127_8004544_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000004708 129.0
SHD2_k127_8010667_0 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005163 374.0
SHD2_k127_8010667_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000003348 236.0
SHD2_k127_8010667_2 - - - - 0.0000000000000000000000001577 121.0
SHD2_k127_8010667_3 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.000000000000000000709 102.0
SHD2_k127_8017029_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 358.0
SHD2_k127_8017029_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000004571 221.0
SHD2_k127_8017029_2 Evidence 5 No homology to any previously reported sequences - - - 0.0000001822 64.0
SHD2_k127_8041311_0 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 593.0
SHD2_k127_8041311_1 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 465.0
SHD2_k127_8041311_2 Phospholipase D. Active site motifs. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 403.0
SHD2_k127_8041311_3 alanine dehydrogenase activity K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 338.0
SHD2_k127_8041311_4 ADP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000004487 265.0
SHD2_k127_8041311_5 - - - - 0.00000000000000000000000000000001359 132.0
SHD2_k127_8041311_6 - - - - 0.0000000000003424 70.0
SHD2_k127_8041311_7 Evidence 5 No homology to any previously reported sequences - - - 0.00000003114 67.0
SHD2_k127_8064567_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 520.0
SHD2_k127_8064567_1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 459.0
SHD2_k127_8064567_10 - - - - 0.00000000000000000000378 108.0
SHD2_k127_8064567_11 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0002743 47.0
SHD2_k127_8064567_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 428.0
SHD2_k127_8064567_3 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 383.0
SHD2_k127_8064567_4 PFAM SPFH domain Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 353.0
SHD2_k127_8064567_5 Protein of unknown function (DUF512) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 353.0
SHD2_k127_8064567_6 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000004469 252.0
SHD2_k127_8064567_7 PFAM glycosyl transferase family 9 K02843 - - 0.0000000000000000000000000000000000000000000008843 182.0
SHD2_k127_8064567_8 MgtC SapB transporter K07507 - - 0.00000000000000000000000000000000005066 142.0
SHD2_k127_8064567_9 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000004573 122.0
SHD2_k127_8089342_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 6.017e-259 810.0
SHD2_k127_8089342_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000005255 199.0
SHD2_k127_8089342_2 TIGRFAM TonB family protein K03832 - - 0.000008339 49.0
SHD2_k127_8099990_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 321.0
SHD2_k127_8099990_1 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.0000000000000000000000000000000000000000000008083 169.0
SHD2_k127_8099990_2 Maf-like protein K06287 GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - 0.0000000000000000000000000000000000000000002037 166.0
SHD2_k127_8099990_3 methyltransferase - - - 0.000000000000000000000000000000000003724 156.0
SHD2_k127_8102423_0 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 464.0
SHD2_k127_8102423_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 424.0
SHD2_k127_8102423_2 Thioredoxin - - - 0.0000000000000000000000128 115.0
SHD2_k127_8102423_3 DinB family - - - 0.000000008142 63.0
SHD2_k127_8102423_4 - - - - 0.00000003374 64.0
SHD2_k127_8103224_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000002741 247.0
SHD2_k127_8103224_1 purine ribonucleoside salvage K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000002484 196.0
SHD2_k127_8103224_2 Zinc metalloprotease (Elastase) - - - 0.000000000000000000000000152 123.0
SHD2_k127_8103224_3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000002783 104.0
SHD2_k127_8103224_4 Calcineurin-like phosphoesterase - - - 0.000000000000001877 92.0
SHD2_k127_8103224_5 cellulose binding K00505 - 1.14.18.1 0.0000000000288 78.0
SHD2_k127_8103224_6 Metallo-peptidase family M12B Reprolysin-like - - - 0.00000002808 68.0
SHD2_k127_8103224_7 TIGRFAM conserved repeat domain - - - 0.00007782 53.0
SHD2_k127_8103637_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 563.0
SHD2_k127_8103637_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 449.0
SHD2_k127_8103637_2 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 425.0
SHD2_k127_8103637_3 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 419.0
SHD2_k127_8103637_4 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000001032 80.0
SHD2_k127_8103637_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000002838 57.0
SHD2_k127_8104280_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 449.0
SHD2_k127_8104280_1 amidohydrolase K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 375.0
SHD2_k127_8104280_2 Class II Aldolase and Adducin N-terminal domain K01628,K11216 - 2.7.1.189,4.1.2.17 0.0000000000000000000000000000000000000000000000000000002727 204.0
SHD2_k127_8104280_3 CYTH domain - - - 0.00000000000000000000000000000000000000000000002512 195.0
SHD2_k127_8104280_4 Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro K07025 - - 0.00000000000000000000000001499 119.0
SHD2_k127_8104280_5 - - - - 0.0000000000000000000000001988 108.0
SHD2_k127_8152678_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 502.0
SHD2_k127_8152678_1 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 342.0
SHD2_k127_8152678_2 Phosphodiester glycosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 303.0
SHD2_k127_8152678_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000003455 187.0
SHD2_k127_8152678_4 WxcM-like, C-terminal K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000002152 172.0
SHD2_k127_8152678_5 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.0000000000000000000000000000000000000001162 162.0
SHD2_k127_8152678_6 Tetratricopeptide repeat - - - 0.0000002932 61.0
SHD2_k127_8161826_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 325.0
SHD2_k127_8161826_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 301.0
SHD2_k127_8161826_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000005472 188.0
SHD2_k127_8161826_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000007562 48.0
SHD2_k127_8184286_0 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008681 484.0
SHD2_k127_8184286_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 428.0
SHD2_k127_8184286_10 3D domain protein - - - 0.0000000000001385 81.0
SHD2_k127_8184286_2 Type II/IV secretion system protein K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 383.0
SHD2_k127_8184286_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000394 328.0
SHD2_k127_8184286_4 Belongs to the arginase family K01476,K01480 - 3.5.3.1,3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000001208 264.0
SHD2_k127_8184286_5 TIGRFAM MazG family protein K02499,K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000007351 235.0
SHD2_k127_8184286_6 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000001749 235.0
SHD2_k127_8184286_7 glutathione-regulated potassium exporter activity - - - 0.0000000000000000000000000000000000000000003669 165.0
SHD2_k127_8184286_8 Cupin domain - - - 0.0000000000000000000007816 106.0
SHD2_k127_8184286_9 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000001047 92.0
SHD2_k127_8194220_0 PFAM Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 514.0
SHD2_k127_8194220_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 398.0
SHD2_k127_8194220_2 CHAD domain containing protein - - - 0.00000000148 63.0
SHD2_k127_8195935_0 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000001123 218.0
SHD2_k127_8195935_1 glycosyl transferase family 2 K20444 - - 0.000000000007186 79.0
SHD2_k127_8195935_2 Sodium:sulfate symporter transmembrane region K14445 - - 0.000003861 51.0
SHD2_k127_8268846_0 Yqey-like protein K09117 - - 0.0000000000000000000000000000000004107 137.0
SHD2_k127_8268846_1 PFAM peptidase M14, carboxypeptidase A - - - 0.00000001652 56.0
SHD2_k127_8270227_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003435 455.0
SHD2_k127_8270227_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 328.0
SHD2_k127_8270227_3 C4-type zinc ribbon domain K07164,K22391 - 3.5.4.16 0.000004913 56.0
SHD2_k127_8276424_0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 336.0
SHD2_k127_8276424_1 oligopeptide transport K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 328.0
SHD2_k127_8276424_2 acetyltransferase - - - 0.000000000000000000000000000000000000000000000517 175.0
SHD2_k127_8286259_0 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 443.0
SHD2_k127_8286259_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000001917 111.0
SHD2_k127_8286259_2 NmrA-like family K00091 - 1.1.1.219 0.000000653 53.0
SHD2_k127_8298032_0 Polysulphide reductase K00185 - - 1.159e-214 679.0
SHD2_k127_8298032_1 Molybdopterin oxidoreductase, iron-sulfur binding subunit K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000556 379.0
SHD2_k127_8298032_2 Protein of unknown function (DUF3341) - - - 0.0000003604 57.0
SHD2_k127_8325155_0 Belongs to the glutamate synthase family K00284 - 1.4.7.1 0.000000000000000000000000000001299 142.0
SHD2_k127_8325155_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.00002136 52.0
SHD2_k127_8348786_0 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001091 269.0
SHD2_k127_8348786_1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001936 200.0
SHD2_k127_8348786_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000004923 186.0
SHD2_k127_8348786_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000005196 172.0
SHD2_k127_8348786_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000001145 136.0
SHD2_k127_8348786_5 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000006976 130.0
SHD2_k127_8348786_6 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000001322 105.0
SHD2_k127_8348786_7 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000007242 102.0
SHD2_k127_8348786_8 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000001124 63.0
SHD2_k127_8395035_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 324.0
SHD2_k127_8395035_1 phosphinothricin N-acetyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000006235 248.0
SHD2_k127_8395035_2 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000008541 198.0
SHD2_k127_8395035_3 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000004009 74.0
SHD2_k127_8395035_4 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000006643 78.0
SHD2_k127_8395035_5 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000003394 49.0
SHD2_k127_8399471_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 7.939e-208 680.0
SHD2_k127_8399471_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 443.0
SHD2_k127_8399471_2 Cytochrome C biogenesis protein transmembrane region K06196,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000173 258.0
SHD2_k127_8399471_3 Fumarylacetoacetate (FAA) hydrolase family K16165 - 3.7.1.20 0.0000000000000000000000000000000000000000000000000000002346 209.0
SHD2_k127_8399471_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000007504 151.0
SHD2_k127_8399471_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000004856 145.0
SHD2_k127_8399471_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000000001324 143.0
SHD2_k127_8431206_0 electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 474.0
SHD2_k127_8431206_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 465.0
SHD2_k127_8431206_2 Belongs to the HesB IscA family K13628,K15724 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.00000000000000000000000000000000834 130.0
SHD2_k127_8431206_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00030 - 1.1.1.41 0.00000000000000000000005821 104.0
SHD2_k127_8431206_4 MerR, DNA binding - - - 0.0000000000000001633 85.0
SHD2_k127_884958_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 408.0
SHD2_k127_884958_1 Peptidase family M23 K01406 - 3.4.24.40 0.00000000000000000000000000000000000000000000009956 190.0
SHD2_k127_884958_2 Glycosyltransferase family 9 (heptosyltransferase) K02843,K02849 - - 0.000000000000000000000000000000000000000001684 171.0
SHD2_k127_884958_3 domain protein - - - 0.000000000000000000000000000000000000004551 168.0
SHD2_k127_884958_4 FlgD Ig-like domain K21449 - - 0.000000000000002182 91.0
SHD2_k127_896981_0 (ABC) transporter K06147,K18890 - - 0.00000000000000000000000000000000000003511 145.0
SHD2_k127_896981_1 lipolytic protein G-D-S-L family K20306 - - 0.0000000000000000002673 100.0
SHD2_k127_896981_2 Belongs to the peptidase S8 family - - - 0.000000000000000001617 102.0
SHD2_k127_896981_3 PFAM Fibronectin, type III domain K01179,K06882 - 3.2.1.4 0.00000000000007323 87.0
SHD2_k127_896981_4 pyrroloquinoline quinone binding - - - 0.0000000003672 75.0
SHD2_k127_902554_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 377.0
SHD2_k127_902554_1 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 338.0
SHD2_k127_902554_2 YCII-related domain - - - 0.0000000000000000000004003 111.0
SHD2_k127_902554_3 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000004594 71.0
SHD2_k127_902554_5 - - - - 0.000005218 54.0
SHD2_k127_927612_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 593.0
SHD2_k127_927612_1 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 593.0
SHD2_k127_927612_10 Tetratricopeptide repeat K11935 - - 0.00000000000000000000000000000000000000000001236 183.0
SHD2_k127_927612_11 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000004346 160.0
SHD2_k127_927612_12 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K01571,K01960 - 4.1.1.3,6.4.1.1 0.00000000000000000000000000000000000000595 150.0
SHD2_k127_927612_13 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000167 164.0
SHD2_k127_927612_15 Belongs to the peptidase S1C family K04771,K04772 - 3.4.21.107 0.0000000000000000000000000828 123.0
SHD2_k127_927612_16 transmembrane transcriptional regulator (anti-sigma factor) - - - 0.0004125 51.0
SHD2_k127_927612_2 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 430.0
SHD2_k127_927612_3 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 412.0
SHD2_k127_927612_4 Permease YjgP YjgQ family protein K07091,K11720 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 327.0
SHD2_k127_927612_5 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 301.0
SHD2_k127_927612_6 Permease YjgP YjgQ K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000006339 248.0
SHD2_k127_927612_7 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000009966 213.0
SHD2_k127_927612_8 2-phosphosulfolactate phosphatase activity K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.000000000000000000000000000000000000000000000000000000005635 207.0
SHD2_k127_927612_9 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000003533 181.0