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Overview

ID MAG03379
Name SHD2_bin.27
Sample SMP0083
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA288
Species
Assembly information
Completeness (%) 57.25
Contamination (%) 0.28
GC content (%) 69.0
N50 (bp) 4,277
Genome size (bp) 1,454,865

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1631

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1000234_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 487.0
SHD2_k127_1000234_1 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 414.0
SHD2_k127_1000234_2 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000002066 205.0
SHD2_k127_1000234_3 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000002439 154.0
SHD2_k127_1069420_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000009705 232.0
SHD2_k127_1069420_1 WLM domain K07043 - - 0.00000000000000000000000000000000000000001799 161.0
SHD2_k127_1069420_2 Phosphate-starvation-inducible E - - - 0.0000000000000000001877 95.0
SHD2_k127_1099790_0 Involved in cell shape control K22222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 605.0
SHD2_k127_1099790_1 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 299.0
SHD2_k127_1120018_0 Glycoside hydrolase family 28 - - - 0.00000000000000000000000000000000000000000000000000000000000000005322 246.0
SHD2_k127_1120018_1 PFAM PEGA domain - - - 0.0008397 52.0
SHD2_k127_1124265_0 Parallel beta-helix repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001396 286.0
SHD2_k127_1143877_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 3.104e-195 615.0
SHD2_k127_1143877_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 355.0
SHD2_k127_1143877_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 0.00000000000000000000000000000000000000000000000000000000000000000002435 238.0
SHD2_k127_1149874_0 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000009236 140.0
SHD2_k127_1172045_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.00000000000000000000000000000000000008425 156.0
SHD2_k127_1172045_1 Winged helix-turn-helix - - - 0.000000000000000000000000000000000001048 143.0
SHD2_k127_1172045_2 Flavodoxin domain - - - 0.000000000000000000000000000001588 136.0
SHD2_k127_1172045_3 - - - - 0.0000000000000000000000005858 114.0
SHD2_k127_1172045_4 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000008782 74.0
SHD2_k127_1172045_5 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000001868 77.0
SHD2_k127_1172983_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 2.144e-266 827.0
SHD2_k127_1172983_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 552.0
SHD2_k127_1172983_2 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 544.0
SHD2_k127_1172983_3 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008325 422.0
SHD2_k127_1172983_4 coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003127 256.0
SHD2_k127_1172983_5 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.00000004705 55.0
SHD2_k127_1186735_0 Glycoside hydrolase family 28 - - - 0.00000000000000000000000000000000000000000000000000000000000001757 238.0
SHD2_k127_1186735_1 - - - - 0.00001652 58.0
SHD2_k127_1186735_2 MASE1 - - - 0.0001391 53.0
SHD2_k127_1214989_0 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 516.0
SHD2_k127_1214989_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 500.0
SHD2_k127_1214989_2 Bacterial Na+/H+ antiporter B (NhaB) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 461.0
SHD2_k127_1222583_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1176.0
SHD2_k127_1222583_1 Methyltransferase type - - - 0.0000000000000000000000000000000000000000000000000000000001418 212.0
SHD2_k127_1222583_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000001923 199.0
SHD2_k127_1222583_3 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000000008055 166.0
SHD2_k127_1222583_4 Armadillo/beta-catenin-like repeats - - - 0.00000000008223 73.0
SHD2_k127_1222583_5 PFAM Uncharacterised protein family UPF0150 - - - 0.0001534 49.0
SHD2_k127_1224609_0 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 421.0
SHD2_k127_1224609_1 Domain of unknown function (DUF1743) - - - 0.000000000000000002705 91.0
SHD2_k127_1230420_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000975 552.0
SHD2_k127_1230420_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 555.0
SHD2_k127_1230420_2 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 326.0
SHD2_k127_1230420_3 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 313.0
SHD2_k127_1230420_4 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000001143 145.0
SHD2_k127_1235324_0 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002603 237.0
SHD2_k127_1235324_1 PFAM PKD domain containing protein - - - 0.000002024 59.0
SHD2_k127_1235324_2 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.00002031 55.0
SHD2_k127_1263064_0 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 610.0
SHD2_k127_1263064_1 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001507 266.0
SHD2_k127_1263064_2 PFAM membrane-bound metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000003736 233.0
SHD2_k127_1263064_3 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000005553 201.0
SHD2_k127_1263064_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.000000000000000000000000000000000000000000000000000001461 209.0
SHD2_k127_1263064_5 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000002258 96.0
SHD2_k127_1263736_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 3.345e-300 936.0
SHD2_k127_1263736_1 Involved in regulation of DNA replication K10725 - - 3.012e-236 735.0
SHD2_k127_1263736_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 491.0
SHD2_k127_1263736_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 483.0
SHD2_k127_1263736_4 serine threonine protein kinase K07178 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008772 341.0
SHD2_k127_1263736_5 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein K00335,K00390,K18853 - 1.5.99.15,1.6.5.3,1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 323.0
SHD2_k127_1263736_6 KH domain protein K06961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000824 254.0
SHD2_k127_1263736_7 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000008245 187.0
SHD2_k127_1263736_8 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000000000000000000000000000001137 173.0
SHD2_k127_1263736_9 methyltransferase activity - - - 0.000000000001554 75.0
SHD2_k127_1299239_0 Flavodoxin-like fold K00355 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000001889 229.0
SHD2_k127_1299239_1 PFAM AMMECR1 domain protein K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000002052 225.0
SHD2_k127_1299239_2 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000211 147.0
SHD2_k127_1299239_3 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000005895 87.0
SHD2_k127_132800_0 Auxin Efflux Carrier K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001399 262.0
SHD2_k127_132800_1 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K07533 - 5.2.1.8 0.0000000000000000000000000000000071 129.0
SHD2_k127_132800_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000006128 113.0
SHD2_k127_132800_3 META domain - - - 0.00000000000000000000000003676 118.0
SHD2_k127_132800_4 META domain - - - 0.0000000000000417 83.0
SHD2_k127_133043_0 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 353.0
SHD2_k127_133043_1 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001011 269.0
SHD2_k127_133043_2 Secreted repeat of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000008921 224.0
SHD2_k127_133043_3 SMART Elongator protein 3 MiaB NifB K22227 - - 0.00000000000000000000000000000000000000000000000000000001448 206.0
SHD2_k127_133043_4 Belongs to the NifH BchL ChlL family K02588 - 1.18.6.1 0.000000000000000000000000000000000001292 143.0
SHD2_k127_133043_5 Uncharacterized conserved protein (DUF2196) - - - 0.0000000000005315 82.0
SHD2_k127_133043_6 PBS lyase HEAT-like repeat - - - 0.0000008413 57.0
SHD2_k127_1342818_0 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 352.0
SHD2_k127_1342818_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 344.0
SHD2_k127_1342818_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000004659 228.0
SHD2_k127_1342818_3 - - - - 0.00000000000000000000000000000000004244 137.0
SHD2_k127_1342818_4 - - - - 0.0000038 56.0
SHD2_k127_1395459_0 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 312.0
SHD2_k127_1395459_1 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000001392 202.0
SHD2_k127_1395459_2 HPP family - - - 0.000000000000003877 79.0
SHD2_k127_1395459_3 Belongs to the UPF0173 family - - - 0.0000000000001251 71.0
SHD2_k127_1405974_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.454e-225 705.0
SHD2_k127_1405974_1 - K16785 - - 0.000000000000000000000000000000000001225 149.0
SHD2_k127_1405974_2 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.0000000000000000000000000000000006345 136.0
SHD2_k127_14472_0 5'-nucleotidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006679 483.0
SHD2_k127_14472_1 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 410.0
SHD2_k127_14472_2 NfeD-like C-terminal, partner-binding - - - 0.00000000000000000000000000000000000000000000001755 174.0
SHD2_k127_14472_3 DsrE/DsrF-like family K09004 - - 0.00000000000005434 79.0
SHD2_k127_1447848_0 TIGRFAM UbiD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 584.0
SHD2_k127_1447848_1 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 538.0
SHD2_k127_1447848_2 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 313.0
SHD2_k127_1447848_3 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000006985 253.0
SHD2_k127_1447848_4 PHP-associated - - - 0.00000000000000000000000000000000000000000000000000000001273 205.0
SHD2_k127_1447848_5 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000002771 183.0
SHD2_k127_1447848_6 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000000003917 117.0
SHD2_k127_1447848_7 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.00000000000003009 77.0
SHD2_k127_1447848_8 PHP-associated - - - 0.00001304 49.0
SHD2_k127_1459540_0 PFAM TrkA-N domain protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 608.0
SHD2_k127_1459540_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008927 306.0
SHD2_k127_1459540_2 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000001208 248.0
SHD2_k127_1459540_3 COG1361 S-layer domain - - - 0.000000000000421 70.0
SHD2_k127_1465821_0 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004334 375.0
SHD2_k127_1465821_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001218 260.0
SHD2_k127_1465821_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.0000000000000000000000000000000000000001709 156.0
SHD2_k127_1481354_0 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 378.0
SHD2_k127_1481354_1 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001306 244.0
SHD2_k127_1481354_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003197 238.0
SHD2_k127_1481354_3 COG1045 Serine acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000012 209.0
SHD2_k127_1481354_4 TIGRFAM small GTP-binding protein K06944 - - 0.00000000002393 64.0
SHD2_k127_1481354_5 - - - - 0.00003235 56.0
SHD2_k127_1531514_0 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000004348 249.0
SHD2_k127_1531514_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000136 244.0
SHD2_k127_1531514_2 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.000000000000000000000000000000000000000000000001566 198.0
SHD2_k127_1531514_3 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000197 146.0
SHD2_k127_1531514_4 - - - - 0.000000000000000003827 94.0
SHD2_k127_1539759_0 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 533.0
SHD2_k127_1539759_1 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 337.0
SHD2_k127_1539759_2 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002816 251.0
SHD2_k127_1539759_3 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000001052 148.0
SHD2_k127_1539759_4 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000000005006 78.0
SHD2_k127_1560395_0 - - - - 0.000000000000000000000000000000000000000000003177 169.0
SHD2_k127_1560395_1 Glycoside hydrolase family 28 - - - 0.0000000000000000000000000004455 116.0
SHD2_k127_1560395_2 Signal peptidase K13280 - 3.4.21.89 0.0000000000281 72.0
SHD2_k127_1570512_0 Predicted metal-binding protein (DUF2284) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 303.0
SHD2_k127_1570512_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000006044 165.0
SHD2_k127_1570512_2 LURP-one-related - - - 0.0000000000000000000000000000000001373 142.0
SHD2_k127_1570512_3 CHAT domain - - - 0.0002154 52.0
SHD2_k127_1589404_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.499e-319 990.0
SHD2_k127_1589404_1 - - - - 0.000000000000000000000000000000000000000000000006292 181.0
SHD2_k127_1589404_2 HEAT repeats - - - 0.0000000000000000000000000000156 124.0
SHD2_k127_1589404_3 Uncharacterised protein family UPF0058 - - - 0.000006361 48.0
SHD2_k127_1662283_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 447.0
SHD2_k127_1662283_1 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.000000000000000000000000000000000000000000004512 167.0
SHD2_k127_1665151_0 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 328.0
SHD2_k127_1665151_1 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000001999 241.0
SHD2_k127_1665151_2 Protein of unknown function (DUF4013) - - - 0.000000000000000000000000000000000000000000000000000000000001711 215.0
SHD2_k127_1665151_3 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000000009543 174.0
SHD2_k127_1665151_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03471 - 3.1.26.4 0.000000000000000000000000000000000000000002689 169.0
SHD2_k127_1665151_5 DNA polymerase beta domain protein region K09717 - - 0.0008459 49.0
SHD2_k127_1681969_0 Putative neutral zinc metallopeptidase K06973 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003041 268.0
SHD2_k127_1681969_1 COG0433 Predicted ATPase - - - 0.0000000000000003054 79.0
SHD2_k127_1681969_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00002726 49.0
SHD2_k127_1683770_0 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.00000000000000000000000000000000000000000000009306 175.0
SHD2_k127_1683770_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000004059 166.0
SHD2_k127_1683770_2 KaiB K08481 - - 0.000000000000000000000000000000003545 131.0
SHD2_k127_1708691_0 PFAM Methyl-coenzyme M reductase, beta subunit K00401 - 2.8.4.1 2.734e-230 719.0
SHD2_k127_1708691_1 PFAM Methyl-coenzyme M reductase gamma subunit K00402 - 2.8.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 451.0
SHD2_k127_1708691_2 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 389.0
SHD2_k127_1708691_3 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 0.0000000000000000000000000000000000000000000000000000000000000008849 219.0
SHD2_k127_1708691_4 PFAM Methyl-coenzyme M reductase, protein D K03422 - - 0.00000000000000000000000000000000000000000000000000000000000001058 232.0
SHD2_k127_1722573_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002648 271.0
SHD2_k127_1767215_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000268 228.0
SHD2_k127_1767215_1 Pas domain - - - 0.0000000000000000000000000000000000000002095 159.0
SHD2_k127_1767215_2 4Fe-4S dicluster domain - - - 0.0000000000000000000000009065 104.0
SHD2_k127_1767215_3 methyltransferase activity K21310 - 2.1.1.334 0.00000000000000000000003174 107.0
SHD2_k127_1767215_4 - - - - 0.00000008343 59.0
SHD2_k127_1767215_5 DNA binding protein K06930 - - 0.000000129 61.0
SHD2_k127_1794241_0 Alpha/beta hydrolase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 511.0
SHD2_k127_1794241_1 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 359.0
SHD2_k127_1794241_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 331.0
SHD2_k127_1794241_3 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.0000000005304 61.0
SHD2_k127_1830187_0 PFAM ABC transporter K00400 - - 1.548e-274 851.0
SHD2_k127_1830187_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 415.0
SHD2_k127_1830187_2 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 301.0
SHD2_k127_1830187_3 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000811 266.0
SHD2_k127_1904302_0 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 298.0
SHD2_k127_1904302_1 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000005276 173.0
SHD2_k127_1904302_2 PFAM response regulator receiveR - - - 0.0000000000000000000000000000000000000000008787 160.0
SHD2_k127_1904302_3 NUDIX domain K03574 - 3.6.1.55 0.0000000000000007971 84.0
SHD2_k127_1904302_4 Histidine kinase-like ATPases - - - 0.0000000000001705 71.0
SHD2_k127_1941304_0 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00125 - 1.17.1.9 1.031e-216 682.0
SHD2_k127_1941304_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 2.661e-204 649.0
SHD2_k127_1941304_2 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 1.772e-198 625.0
SHD2_k127_1941304_3 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 367.0
SHD2_k127_1941304_4 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 314.0
SHD2_k127_1941304_5 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000001883 149.0
SHD2_k127_1941304_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000004938 111.0
SHD2_k127_1943630_0 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000007285 196.0
SHD2_k127_1943630_1 - - - - 0.000000000003708 74.0
SHD2_k127_1943630_2 - - - - 0.000002799 53.0
SHD2_k127_1943630_3 - - - - 0.0006473 47.0
SHD2_k127_1972980_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000001475 254.0
SHD2_k127_1972980_1 PAS domain - - - 0.000000000000000000000000000005428 126.0
SHD2_k127_1972980_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 0.000000000000003909 89.0
SHD2_k127_1977398_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000003659 149.0
SHD2_k127_1977398_1 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000003862 135.0
SHD2_k127_1977398_2 PFAM Carboxymuconolactone decarboxylase - - - 0.000000000000000000000000000133 119.0
SHD2_k127_1977398_3 PFAM NHL repeat containing protein - - - 0.0000000000000000000001439 115.0
SHD2_k127_1977398_4 DNA binding protein - - - 0.0002061 44.0
SHD2_k127_1989302_0 Glycoside hydrolase family 28 - - - 0.00000000000000000003178 93.0
SHD2_k127_2036929_0 Belongs to the peptidase M24B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 535.0
SHD2_k127_2036929_1 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.000000000000000000000000000000000000000000000000000000000000001455 225.0
SHD2_k127_2036929_2 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000005715 189.0
SHD2_k127_2036929_3 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000302 138.0
SHD2_k127_2047062_0 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000001577 176.0
SHD2_k127_2047062_1 RuvA, C-terminal domain K03550 - 3.6.4.12 0.00000000000000000000000000000000000000005353 158.0
SHD2_k127_2047062_2 Rieske 2Fe-2S - - - 0.00000000000000000000003122 103.0
SHD2_k127_2047062_3 Competence protein K06198 - - 0.0005739 51.0
SHD2_k127_2113215_0 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 385.0
SHD2_k127_2113215_1 Diphthamide synthase K06927 - 6.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 298.0
SHD2_k127_2113215_2 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000007495 236.0
SHD2_k127_2113215_3 Belongs to the UPF0212 family K09731 - - 0.0000000000000000000000000000000000000000000007799 171.0
SHD2_k127_2113215_4 Predicted membrane protein (DUF2070) K08979 - - 0.00000000000000000000000000000000000009348 151.0
SHD2_k127_2113215_5 Family of unknown function (DUF5350) - - - 0.00000000000000000000000000002589 120.0
SHD2_k127_2113215_6 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.000000000000001465 78.0
SHD2_k127_2116519_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 7.148e-230 732.0
SHD2_k127_2116519_1 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001501 270.0
SHD2_k127_2146892_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 3.562e-233 741.0
SHD2_k127_2146892_1 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001008 272.0
SHD2_k127_2146892_2 Involved in protein export. The function of the beta subunit is - GO:0003674,GO:0005085,GO:0005086,GO:0005488,GO:0005515,GO:0008150,GO:0019899,GO:0051020,GO:0065007,GO:0065009,GO:0098772 - 0.000000000000003561 76.0
SHD2_k127_2148057_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 340.0
SHD2_k127_2148057_1 Flavodoxin domain - - - 0.000000000000000000000000000000000000000000000000001064 188.0
SHD2_k127_2148057_2 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000001309 148.0
SHD2_k127_2163210_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 1.987e-239 746.0
SHD2_k127_2163210_1 Domain of unknown function (DUF3821) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000985 443.0
SHD2_k127_2163210_2 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000003206 187.0
SHD2_k127_2175528_0 LUD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 292.0
SHD2_k127_2175528_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001252 278.0
SHD2_k127_2175528_2 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.00000000000000000000000000000000000000000000000000000336 193.0
SHD2_k127_2180789_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 523.0
SHD2_k127_2180789_1 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000000000000000000000000000002851 155.0
SHD2_k127_2180789_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000004072 152.0
SHD2_k127_2180789_3 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000004939 96.0
SHD2_k127_2213268_0 DEAD DEAH box helicase domain protein K10896 - - 3.592e-281 890.0
SHD2_k127_2213268_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 6.819e-268 844.0
SHD2_k127_2213268_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 306.0
SHD2_k127_2213268_3 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 310.0
SHD2_k127_2213268_4 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 300.0
SHD2_k127_2213268_5 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000568 150.0
SHD2_k127_2213268_6 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.000000000000003052 79.0
SHD2_k127_2213976_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 436.0
SHD2_k127_2213976_1 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 357.0
SHD2_k127_2213976_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.0000000000000000000000000000004806 126.0
SHD2_k127_2213976_3 hydrolase K04794 - 3.1.1.29 0.00000000000003699 72.0
SHD2_k127_2214251_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004531 288.0
SHD2_k127_2214251_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001177 281.0
SHD2_k127_2214251_2 - - - - 0.00000000000000000000000006286 111.0
SHD2_k127_2253451_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 6.213e-227 710.0
SHD2_k127_2253451_1 Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000004245 130.0
SHD2_k127_2256734_0 Uncharacterized membrane protein (DUF2298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 569.0
SHD2_k127_22577_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 3.722e-210 658.0
SHD2_k127_22577_1 Glycogen debranching enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 512.0
SHD2_k127_22577_2 - - - - 0.0000000000000000000000000000000259 143.0
SHD2_k127_22577_3 PFAM membrane-bound metal-dependent hydrolase - - - 0.00000000000000000000000000001494 122.0
SHD2_k127_227726_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 484.0
SHD2_k127_227726_1 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 325.0
SHD2_k127_227726_2 PFAM GHMP kinase K06982 - 2.7.1.169 0.00000000000000000000000000000000000000000000000000000000000000000002588 243.0
SHD2_k127_227726_3 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000006878 173.0
SHD2_k127_227726_4 COG0470 ATPase involved in DNA replication K04801 - - 0.0000000000000000000000000000001565 136.0
SHD2_k127_227726_5 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000158 108.0
SHD2_k127_2287241_0 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 424.0
SHD2_k127_2287241_1 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 373.0
SHD2_k127_2287241_2 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008329 284.0
SHD2_k127_2287241_3 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000006793 194.0
SHD2_k127_2287241_4 Histidine kinase - - - 0.0000000000000000000000000005556 117.0
SHD2_k127_2306259_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000004235 178.0
SHD2_k127_2306259_1 - - - - 0.0000000000000001306 89.0
SHD2_k127_2315210_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001266 244.0
SHD2_k127_2315210_1 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000001832 136.0
SHD2_k127_2315210_2 Hemerythrin - - - 0.00001158 53.0
SHD2_k127_2331167_0 Cache_2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 412.0
SHD2_k127_2331167_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007402 314.0
SHD2_k127_2337639_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 290.0
SHD2_k127_2337639_1 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000009596 166.0
SHD2_k127_2337639_2 EVE domain - - - 0.000000000000000000000000000000000000000001446 160.0
SHD2_k127_2337639_3 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000001263 91.0
SHD2_k127_2337639_4 PFAM blue (type 1) copper domain protein - - - 0.00000000000000004368 91.0
SHD2_k127_2337639_5 PFAM Yip1 domain - - - 0.000000000000007313 82.0
SHD2_k127_2393128_0 PFAM PKD domain containing protein - - - 0.00000000000008224 77.0
SHD2_k127_2393128_1 PKD domain - - - 0.0000001094 63.0
SHD2_k127_2395100_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 599.0
SHD2_k127_2395100_1 Sulfide dehydrogenase (Flavoprotein) subunit SudB K00528,K02823 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 374.0
SHD2_k127_2417201_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 3.773e-202 639.0
SHD2_k127_2417201_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000004049 190.0
SHD2_k127_2440480_0 PFAM aldo keto reductase K07079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 383.0
SHD2_k127_2440480_1 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 303.0
SHD2_k127_2440480_2 - - - - 0.000000000000000000000000000000000000000000000000000000003974 204.0
SHD2_k127_2440480_3 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000000000009261 171.0
SHD2_k127_2440480_4 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.00000000000000000000000000001371 117.0
SHD2_k127_2463693_1 alpha/beta hydrolase fold - - - 0.0000000000000000000000002927 119.0
SHD2_k127_2463693_2 hemerythrin HHE cation binding domain - - - 0.00004705 51.0
SHD2_k127_2503138_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000001589 163.0
SHD2_k127_2503138_1 structural constituent of ribosome K02962 - - 0.0000000000000000000005337 96.0
SHD2_k127_2503138_2 Transcriptional regulator K21219,K21220 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000008049 83.0
SHD2_k127_2558075_0 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 355.0
SHD2_k127_2558075_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 309.0
SHD2_k127_2558075_2 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000002463 207.0
SHD2_k127_2558075_3 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000000001744 165.0
SHD2_k127_2558075_4 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000008951 146.0
SHD2_k127_2558075_5 Peptidase A4 family - - - 0.000000000000000000000000000000000004916 149.0
SHD2_k127_256142_0 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000009521 151.0
SHD2_k127_256142_1 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000007805 87.0
SHD2_k127_256142_2 Protein of unknown function (DUF2953) - - - 0.000000000000421 78.0
SHD2_k127_2562021_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 8.583e-229 712.0
SHD2_k127_2562021_1 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 319.0
SHD2_k127_2562021_2 - - - - 0.0000000000000000000000000000000824 126.0
SHD2_k127_2577208_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 474.0
SHD2_k127_2577208_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 394.0
SHD2_k127_2577208_2 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000003278 244.0
SHD2_k127_2577208_3 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.0000000000000000000000000000000000002072 150.0
SHD2_k127_2584251_0 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 400.0
SHD2_k127_2584251_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 334.0
SHD2_k127_2584251_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002899 263.0
SHD2_k127_2584251_3 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001291 241.0
SHD2_k127_2584251_4 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000005228 182.0
SHD2_k127_2584251_5 Transport of potassium into the cell K03549 - - 0.0000000000000005018 78.0
SHD2_k127_2586516_0 PFAM PilT protein domain protein K06865 - - 8.749e-261 817.0
SHD2_k127_2586516_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006329 551.0
SHD2_k127_2586516_2 parallel beta-helix repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009931 353.0
SHD2_k127_2586516_3 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000001191 228.0
SHD2_k127_2586516_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.00000000000000000000000000000000000000000000000000004201 190.0
SHD2_k127_2606709_0 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 2.639e-197 624.0
SHD2_k127_2606709_1 PFAM SOUL heme-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000006406 213.0
SHD2_k127_2606709_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000001863 192.0
SHD2_k127_2606709_3 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000001212 147.0
SHD2_k127_2606709_4 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000009062 138.0
SHD2_k127_2606709_5 protein conserved in archaea - - - 0.000000000000000000148 98.0
SHD2_k127_2606709_6 Conserved repeat domain - - - 0.00000000004341 72.0
SHD2_k127_2606709_7 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000007424 56.0
SHD2_k127_2609109_0 Stage II sporulation protein E K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 563.0
SHD2_k127_2609109_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 519.0
SHD2_k127_2609109_2 PFAM Radical SAM domain protein K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005304 274.0
SHD2_k127_2609109_3 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000002109 156.0
SHD2_k127_2609109_4 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.0000000000000000000000000001101 119.0
SHD2_k127_2609109_5 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.000000000000001832 80.0
SHD2_k127_2615306_0 Domain of unknown function (DUF4445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 539.0
SHD2_k127_2615306_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 439.0
SHD2_k127_2635293_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1429.0
SHD2_k127_2635293_1 Helix-turn-helix domain - - - 0.000000000000000000000000000008978 122.0
SHD2_k127_2635293_2 Protein of unknown function (DUF2769) - - - 0.000000000000000003467 88.0
SHD2_k127_2635293_3 - - - - 0.000000000000003721 81.0
SHD2_k127_2635293_4 Hemerythrin HHE cation binding domain - - - 0.000000648 58.0
SHD2_k127_2643321_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1187.0
SHD2_k127_2643321_1 chromosome segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000000000000000000000000000164 215.0
SHD2_k127_2643321_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000009651 158.0
SHD2_k127_2643321_3 - - - - 0.00000000000000000000000000000000003031 142.0
SHD2_k127_2670185_0 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001665 280.0
SHD2_k127_2670185_1 sensor histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000248 301.0
SHD2_k127_2685515_0 parallel beta-helix repeat - - - 0.000000000000000000000000000000000000000000000000000000000000106 235.0
SHD2_k127_2685515_1 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.0000000000000008407 91.0
SHD2_k127_2685515_2 serine-type endopeptidase activity - - - 0.00000000000003155 86.0
SHD2_k127_2685515_3 COG3210 Large exoproteins involved in heme utilization or adhesion K15125 - - 0.000326 52.0
SHD2_k127_271320_0 ATP-binding region, ATPase domain protein K03413,K07662,K07667 - - 3.829e-198 627.0
SHD2_k127_271320_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000001195 158.0
SHD2_k127_2725800_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009297 391.0
SHD2_k127_2725800_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 339.0
SHD2_k127_2725800_2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 302.0
SHD2_k127_2725800_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000008018 115.0
SHD2_k127_2725800_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000005433 98.0
SHD2_k127_2725800_5 Psort location Periplasmic, score K09807 - - 0.0000008372 56.0
SHD2_k127_2731616_0 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 577.0
SHD2_k127_2731616_1 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008376 256.0
SHD2_k127_2731616_2 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000007593 192.0
SHD2_k127_2790130_0 SMART Elongator protein 3 MiaB NifB - - - 1.534e-252 790.0
SHD2_k127_2790130_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 546.0
SHD2_k127_2790695_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 596.0
SHD2_k127_2790695_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 443.0
SHD2_k127_2790695_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 334.0
SHD2_k127_2790695_3 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009104 287.0
SHD2_k127_2790695_4 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000001112 244.0
SHD2_k127_2800330_0 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 531.0
SHD2_k127_2800330_1 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001688 283.0
SHD2_k127_2800330_2 PFAM Glycosyl transferase, group 1 K12996 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000003672 241.0
SHD2_k127_2800330_3 to orf2, orf11, orf12, orf13, orf14, orf15 of fosmid clone 4B7mr3 - - - 0.000000000000000000000000000000000000000000000000001586 195.0
SHD2_k127_2800330_4 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000003015 58.0
SHD2_k127_280548_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 392.0
SHD2_k127_280548_1 ATP-grasp domain K06914 - 6.3.4.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 370.0
SHD2_k127_280548_2 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 351.0
SHD2_k127_2858499_0 LURP-one-related - - - 0.000000000000000000000000000000000000000000000000000000000000000001553 235.0
SHD2_k127_2858499_1 Permease - - - 0.0000000000000000000000000000000002296 147.0
SHD2_k127_2858499_3 membrane protein of uknown function UCP014873 - - - 0.00000000000001408 83.0
SHD2_k127_2859007_0 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 381.0
SHD2_k127_2859007_1 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005333 262.0
SHD2_k127_2859007_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000004576 207.0
SHD2_k127_2859007_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000086 66.0
SHD2_k127_2890165_0 Glycoside hydrolase family 28 K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 411.0
SHD2_k127_2890165_1 toxin activity - - - 0.00000000000000000000000000000005267 137.0
SHD2_k127_2890165_2 toxin activity - - - 0.0000000007474 66.0
SHD2_k127_2898768_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 3.464e-229 721.0
SHD2_k127_2898768_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004479 490.0
SHD2_k127_2898768_2 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 321.0
SHD2_k127_2898768_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000008646 208.0
SHD2_k127_2898768_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000008593 152.0
SHD2_k127_2898768_5 PFAM PUA domain containing protein K07398 - - 0.000000000000005799 78.0
SHD2_k127_2898768_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000975 75.0
SHD2_k127_291216_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008017 317.0
SHD2_k127_291216_1 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 285.0
SHD2_k127_291216_2 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001979 248.0
SHD2_k127_291216_3 Predicted membrane protein (DUF2085) - - - 0.000000006351 66.0
SHD2_k127_2952668_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 477.0
SHD2_k127_2952668_1 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 445.0
SHD2_k127_2952668_2 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007751 314.0
SHD2_k127_2952668_3 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000003772 247.0
SHD2_k127_2952668_4 DNA methylase K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000009347 202.0
SHD2_k127_2952668_5 - - - - 0.000001143 58.0
SHD2_k127_2981293_0 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 529.0
SHD2_k127_2981293_1 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004404 268.0
SHD2_k127_2981293_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000001526 231.0
SHD2_k127_2981293_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000001554 185.0
SHD2_k127_2986438_0 Ferrous iron transport B domain protein K04759 - - 2.064e-243 765.0
SHD2_k127_2986438_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000009132 224.0
SHD2_k127_2992068_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 2.701e-196 619.0
SHD2_k127_2992068_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 522.0
SHD2_k127_2992068_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000001658 258.0
SHD2_k127_2992068_3 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000186 206.0
SHD2_k127_2992068_4 - - - - 0.00000000000000000000000000000000000001301 159.0
SHD2_k127_3022026_0 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 287.0
SHD2_k127_3022026_1 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000128 109.0
SHD2_k127_3022026_2 membrane - - - 0.00000000000000000000003572 104.0
SHD2_k127_3056098_0 PFAM SufBD protein K07033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 505.0
SHD2_k127_3056098_1 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 374.0
SHD2_k127_3056098_2 sugar phosphatases of the HAD superfamily K02566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000241 260.0
SHD2_k127_3056098_3 - - - - 0.000000000000000000000000000000000000000000000000000000000002213 228.0
SHD2_k127_3056098_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000005517 101.0
SHD2_k127_3067193_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 465.0
SHD2_k127_3067193_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.000000000000000000000000000000000000000002667 157.0
SHD2_k127_3089878_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.833e-251 787.0
SHD2_k127_3089878_1 PFAM regulatory protein, MarR - - - 0.000000000000000000000000000000000000000003189 175.0
SHD2_k127_3089878_2 PAS domain K00974,K02485 - 2.7.7.72 0.00000000000000000000000001208 124.0
SHD2_k127_3124684_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 603.0
SHD2_k127_3124684_1 membrane-associated protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001762 247.0
SHD2_k127_3124684_2 Probably functions as a manganese efflux pump - - - 0.000000000000009717 77.0
SHD2_k127_3127811_0 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 336.0
SHD2_k127_3127811_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000001078 245.0
SHD2_k127_3127811_2 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000002865 202.0
SHD2_k127_3127811_3 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000006425 133.0
SHD2_k127_3127811_4 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.000008681 56.0
SHD2_k127_313961_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 4.315e-287 889.0
SHD2_k127_313961_1 HTH-type transcriptional regulatory protein K07728 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 294.0
SHD2_k127_313961_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000141 219.0
SHD2_k127_31551_0 DEAD DEAH box helicase domain protein K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 540.0
SHD2_k127_31551_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 323.0
SHD2_k127_31551_2 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 303.0
SHD2_k127_3158105_0 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 386.0
SHD2_k127_3172742_0 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 344.0
SHD2_k127_3172742_1 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000000000000000000000001497 143.0
SHD2_k127_321285_0 - - - - 0.000000000000000000000000000000000000000000000001197 182.0
SHD2_k127_3230046_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.831e-283 880.0
SHD2_k127_3230046_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 451.0
SHD2_k127_3230046_2 transferase hexapeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001843 272.0
SHD2_k127_3230046_3 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.000000000000000000000000000000000000000000000000000000000000005518 226.0
SHD2_k127_3230046_4 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.0000000000000000000000001469 106.0
SHD2_k127_3237941_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 1.343e-239 754.0
SHD2_k127_3237941_1 Archaeal Type IV pilin, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 463.0
SHD2_k127_3237941_2 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.000000000000000000000000000000000000000003904 157.0
SHD2_k127_3279977_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 511.0
SHD2_k127_3279977_1 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000005641 167.0
SHD2_k127_3279977_2 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000001918 64.0
SHD2_k127_328587_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 2.553e-247 771.0
SHD2_k127_328587_1 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000000000000000000000000000000003836 184.0
SHD2_k127_328587_2 Cupin domain - - - 0.0000000000000000000000000000000000000000001154 162.0
SHD2_k127_328587_3 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 0.0000002859 51.0
SHD2_k127_3303407_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 561.0
SHD2_k127_3303407_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 468.0
SHD2_k127_3303407_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.0000000000000000000000000000000000002951 143.0
SHD2_k127_3303407_3 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000006379 103.0
SHD2_k127_3310775_0 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 344.0
SHD2_k127_3310775_1 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000002029 226.0
SHD2_k127_3310775_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000003961 103.0
SHD2_k127_3310775_3 PFAM phosphatidate cytidylyltransferase - - - 0.000000237 53.0
SHD2_k127_3315920_0 AAA domain, putative AbiEii toxin, Type IV TA system K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 324.0
SHD2_k127_3315920_1 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 305.0
SHD2_k127_3315920_2 PFAM Cobalt transport protein K16785 - - 0.000000000000000000000000000000000000000000000000000000000000002519 226.0
SHD2_k127_3315920_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000002134 196.0
SHD2_k127_3335245_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 410.0
SHD2_k127_3335245_1 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 396.0
SHD2_k127_3335245_2 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 380.0
SHD2_k127_3335245_3 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 310.0
SHD2_k127_3335245_4 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007922 303.0
SHD2_k127_3335245_5 parallel beta-helix repeat - - - 0.0000000000000000000000000000000000000000000000141 185.0
SHD2_k127_3335245_6 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000000346 110.0
SHD2_k127_3335245_7 - - - - 0.000000000000000000000001047 107.0
SHD2_k127_3335245_8 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000001269 94.0
SHD2_k127_3339712_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0 1010.0
SHD2_k127_3339712_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 600.0
SHD2_k127_3339712_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 338.0
SHD2_k127_3339712_3 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006688 297.0
SHD2_k127_3339712_4 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 287.0
SHD2_k127_3339712_5 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000000000008156 140.0
SHD2_k127_3382607_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 1.549e-290 902.0
SHD2_k127_3382607_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.638e-224 703.0
SHD2_k127_3382607_10 binds to the 23S rRNA K02922 - - 0.00000000000000000000000000003111 117.0
SHD2_k127_3382607_11 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.00000000000000000000000001206 111.0
SHD2_k127_3382607_12 RNA-binding protein involved in rRNA processing K07569 - - 0.000000000000000000000001634 104.0
SHD2_k127_3382607_13 Cellulosome anchoring protein cohesin region - - - 0.00000002055 63.0
SHD2_k127_3382607_2 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 352.0
SHD2_k127_3382607_3 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 343.0
SHD2_k127_3382607_4 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005185 271.0
SHD2_k127_3382607_5 PFAM ribosomal protein S8E K02995 - - 0.000000000000000000000000000000000000000000000000000000000005689 209.0
SHD2_k127_3382607_6 PFAM PUA domain containing protein K07575 - - 0.00000000000000000000000000000000000000000000000000000000001467 209.0
SHD2_k127_3382607_7 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000000000005123 201.0
SHD2_k127_3382607_8 protein conserved in archaea - - - 0.000000000000000000000000000000000000004718 154.0
SHD2_k127_3382607_9 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.000000000000000000000000000000000001112 139.0
SHD2_k127_341224_0 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 393.0
SHD2_k127_3444442_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 370.0
SHD2_k127_3444442_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009233 284.0
SHD2_k127_3444442_2 protein conserved in archaea - - - 0.0000000000000000000000000004727 122.0
SHD2_k127_3444442_3 - - - - 0.000000000001861 72.0
SHD2_k127_3450936_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 404.0
SHD2_k127_3450936_1 Domain of unknown function DUF128 K21640 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 365.0
SHD2_k127_3450936_2 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 351.0
SHD2_k127_3450936_3 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003506 331.0
SHD2_k127_3450936_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 319.0
SHD2_k127_3450936_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000000000000000000002718 221.0
SHD2_k127_3450936_6 Yip1 domain - - - 0.0000000000000000000000000000000000000000000000000000003871 202.0
SHD2_k127_3450936_7 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000001586 108.0
SHD2_k127_3453049_0 Ribonuclease R winged-helix domain K09720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 468.0
SHD2_k127_3453049_1 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000006207 166.0
SHD2_k127_3453049_2 META domain - - - 0.000000000000000000001444 109.0
SHD2_k127_3469085_0 deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 376.0
SHD2_k127_3469927_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007983 477.0
SHD2_k127_3469927_1 COG0491 Zn-dependent K01069 - 3.1.2.6 0.000000000001281 69.0
SHD2_k127_3475170_0 Conserved region in glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 557.0
SHD2_k127_3475170_1 Multicopper K06324 - 1.16.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 331.0
SHD2_k127_3475170_2 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000002105 89.0
SHD2_k127_3475170_3 PFAM PKD domain containing protein - - - 0.0000000000525 73.0
SHD2_k127_3526241_0 Domain of unknown function (DUF1890) - - - 0.00000000000000000000000000000000000000000000000000000000000415 212.0
SHD2_k127_3526241_1 Glyoxalase-like domain K06996 - - 0.00000000000000000000000000000002795 134.0
SHD2_k127_3526241_2 Domain of unknown function (DUF1894) - - - 0.00000000000000000000016 99.0
SHD2_k127_3526241_3 Glyoxalase-like domain K06996 - - 0.0000000000000002762 79.0
SHD2_k127_3526241_4 PFAM Uncharacterised protein family UPF0118 - - - 0.0000527 53.0
SHD2_k127_3534628_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 430.0
SHD2_k127_3534628_1 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 363.0
SHD2_k127_3534628_2 Mitochondrial small ribosomal subunit Rsm22 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 342.0
SHD2_k127_3534628_3 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000013 260.0
SHD2_k127_3534628_4 - - - - 0.000000000000000000000000000000000000000008776 162.0
SHD2_k127_3534628_5 Multicopper K06324 - 1.16.3.3 0.0000000000000000000001826 103.0
SHD2_k127_3534628_6 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000117 75.0
SHD2_k127_3538904_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000003234 152.0
SHD2_k127_3562449_0 Glycoside hydrolase family 28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 459.0
SHD2_k127_3562449_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 301.0
SHD2_k127_3562449_2 B-block binding subunit of TFIIIC - - - 0.0000000000000000000000000000000000000000000002367 169.0
SHD2_k127_3562449_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K00619 - 2.3.1.1 0.000000000000000000000000000000000000000001947 160.0
SHD2_k127_3562449_4 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000000003888 134.0
SHD2_k127_3562449_5 - - - - 0.0000000000000000000001743 106.0
SHD2_k127_3609016_0 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 329.0
SHD2_k127_3609016_1 Histidine kinase - - - 0.000000001639 58.0
SHD2_k127_3620945_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 495.0
SHD2_k127_3620945_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000006293 76.0
SHD2_k127_3621736_0 Pas domain - - - 5.702e-265 836.0
SHD2_k127_3621736_2 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000003838 174.0
SHD2_k127_3628916_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 5.787e-291 907.0
SHD2_k127_3628916_1 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000000744 136.0
SHD2_k127_3628916_2 PFAM Radical SAM domain protein - - - 0.0000000000000000000000003291 106.0
SHD2_k127_3628916_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000006871 88.0
SHD2_k127_3674236_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 3.173e-224 706.0
SHD2_k127_3674236_1 ADP-ribosylglycohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001944 296.0
SHD2_k127_3674236_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000001635 191.0
SHD2_k127_3675370_0 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000000002161 256.0
SHD2_k127_3675370_1 - - - - 0.0000000000000000000001108 103.0
SHD2_k127_3675370_2 - - - - 0.00000000000000004445 83.0
SHD2_k127_3675370_3 - - - - 0.000000000001156 71.0
SHD2_k127_369580_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 9.071e-300 942.0
SHD2_k127_369580_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 473.0
SHD2_k127_369580_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001132 250.0
SHD2_k127_369580_3 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007893 247.0
SHD2_k127_369580_4 PFAM peptidase zinc-dependent K06974 - - 0.000000000000000000000000000000000000000000000000000000000801 212.0
SHD2_k127_369580_5 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000002573 158.0
SHD2_k127_369580_6 Belongs to the UPF0146 family K09713 - - 0.0000000000000000000000000000000426 138.0
SHD2_k127_369580_7 - - - - 0.000000000000000000000000003139 123.0
SHD2_k127_369580_8 - - - - 0.0000000253 66.0
SHD2_k127_3696375_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 6.187e-251 778.0
SHD2_k127_3696375_1 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 473.0
SHD2_k127_3696375_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 421.0
SHD2_k127_3696375_3 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000648 282.0
SHD2_k127_3696375_4 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000003731 241.0
SHD2_k127_3696375_5 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000612 203.0
SHD2_k127_3696375_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000008224 92.0
SHD2_k127_3699455_0 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 519.0
SHD2_k127_3699455_1 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 372.0
SHD2_k127_3699455_2 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00004984 51.0
SHD2_k127_3703170_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 469.0
SHD2_k127_3703170_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 430.0
SHD2_k127_3703170_2 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 413.0
SHD2_k127_3703170_3 Oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000002108 267.0
SHD2_k127_3703170_4 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000003958 251.0
SHD2_k127_3703170_5 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000004873 126.0
SHD2_k127_3732557_0 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006012 244.0
SHD2_k127_3732557_1 Domain of unknown function (DUF305) - - - 0.00000000000000000000001631 110.0
SHD2_k127_3740547_0 Helix-hairpin-helix domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 338.0
SHD2_k127_3740547_1 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000002221 263.0
SHD2_k127_3740547_2 secretion by the type IV secretion system K07332 - - 0.000000000043 71.0
SHD2_k127_3749876_0 Belongs to the UPF0305 family K07012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001183 263.0
SHD2_k127_3749876_1 Conserved repeat domain - - - 0.000000000000000000000000000000000000000000002896 181.0
SHD2_k127_3749876_2 SMART cellulose binding type IV - - - 0.0000000000000000006385 100.0
SHD2_k127_3749876_3 Histidine kinase A domain protein - - - 0.0000002897 59.0
SHD2_k127_3759673_0 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005989 277.0
SHD2_k127_3759673_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002744 243.0
SHD2_k127_3759673_2 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000137 173.0
SHD2_k127_376207_0 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005756 295.0
SHD2_k127_376207_1 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000002749 167.0
SHD2_k127_376207_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000002612 57.0
SHD2_k127_3780149_0 Heat shock 70 kDa protein K04043 - - 2.806e-250 786.0
SHD2_k127_3780149_1 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 1.187e-208 660.0
SHD2_k127_3780149_2 Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001365 260.0
SHD2_k127_3780149_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000003694 169.0
SHD2_k127_3780149_4 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000000000000000002183 162.0
SHD2_k127_3780149_5 Protein of unknown function (DUF4013) - - - 0.00000000000000000000000000000007751 134.0
SHD2_k127_3787483_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.073e-236 739.0
SHD2_k127_3787483_1 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000000000001129 154.0
SHD2_k127_3787483_2 - - - - 0.00000004056 64.0
SHD2_k127_3787483_3 SMP-30/Gluconolaconase/LRE-like region - - - 0.0007365 43.0
SHD2_k127_3796134_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 432.0
SHD2_k127_3796134_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 325.0
SHD2_k127_3796134_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000001653 201.0
SHD2_k127_3796134_3 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000000000000001465 164.0
SHD2_k127_3796134_4 GAF domain protein - - - 0.00000000000000000000000000002801 135.0
SHD2_k127_3796134_5 nucleic acid binding OB-fold tRNA helicase-type - - - 0.0000000000000001942 83.0
SHD2_k127_3811600_0 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 338.0
SHD2_k127_3811600_1 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000009922 232.0
SHD2_k127_3811600_2 - - - - 0.000000000000000000000000000000000000000000000000008617 195.0
SHD2_k127_3811600_3 Flavodoxin - - - 0.00000000000000000000000000000000000000000481 160.0
SHD2_k127_3811600_4 Transcription factor Pcc1 K09741 - - 0.000000002486 64.0
SHD2_k127_3811600_5 Probably involved in the biogenesis of the ribosome K14561 - - 0.0002451 48.0
SHD2_k127_3814222_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.8e-242 755.0
SHD2_k127_3814222_1 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 580.0
SHD2_k127_3814222_2 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 425.0
SHD2_k127_3814222_3 - - - - 0.000000000000000000000000000000000000000000000002079 181.0
SHD2_k127_3836471_0 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007926 529.0
SHD2_k127_3836471_1 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 402.0
SHD2_k127_3836471_2 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 320.0
SHD2_k127_3836471_3 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000001493 254.0
SHD2_k127_3836471_4 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000176 241.0
SHD2_k127_3836471_5 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000002825 194.0
SHD2_k127_3836471_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000003028 106.0
SHD2_k127_3906863_0 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 509.0
SHD2_k127_393045_0 GTP-binding signal recognition particle SRP54 K02404 - - 0.0000000000000000000000000000000000000000000000000000000000000001585 238.0
SHD2_k127_393045_1 bacterial-type flagellum organization K02282,K04562 - - 0.0000000000000000000000000000000000000000000000004407 187.0
SHD2_k127_3944096_0 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 450.0
SHD2_k127_3944195_0 phosphoesterase RecJ domain protein - - - 8.271e-228 715.0
SHD2_k127_3944195_1 Multicopper - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 572.0
SHD2_k127_3944195_2 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.000000000000000000000000000000000000000000000009698 175.0
SHD2_k127_3944195_3 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000000000000242 82.0
SHD2_k127_3945639_0 AAA domain K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 368.0
SHD2_k127_3945639_1 - - - - 0.0000000000000000000000000000000000000000000003612 170.0
SHD2_k127_396715_0 Transport of potassium into the cell K03549 - - 1.872e-262 821.0
SHD2_k127_396715_1 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002022 268.0
SHD2_k127_396715_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000001081 65.0
SHD2_k127_3977255_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005915 522.0
SHD2_k127_3977255_1 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000002087 241.0
SHD2_k127_3977255_2 Rubrerythrin K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000001696 236.0
SHD2_k127_3977255_3 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000001959 207.0
SHD2_k127_3990619_0 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 383.0
SHD2_k127_3990619_1 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000006335 134.0
SHD2_k127_4008236_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 9.764e-260 806.0
SHD2_k127_4008236_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.846e-237 747.0
SHD2_k127_4008236_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 430.0
SHD2_k127_4029239_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 428.0
SHD2_k127_4029239_1 PFAM Cysteine-rich small domain K02232,K04720,K05934,K07162,K08260 - 2.1.1.131,3.5.1.90,4.1.1.81,6.3.5.10 0.0000000000000000000000000000000000000000004858 168.0
SHD2_k127_4029239_2 Domain of unknown function (DUF1858) - - - 0.00000000000000000000003578 101.0
SHD2_k127_4029239_3 Anaerobic ribonucleoside-triphosphate reductase - - - 0.000000000000001371 76.0
SHD2_k127_4041665_0 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 479.0
SHD2_k127_4041665_1 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000002085 216.0
SHD2_k127_4041665_2 PFAM NHL repeat containing protein - - - 0.000000000000000000001191 109.0
SHD2_k127_4041665_3 Phospholipid methyltransferase - - - 0.000000000003478 74.0
SHD2_k127_4041665_4 - - - - 0.00000003136 61.0
SHD2_k127_4041665_5 HTH DNA binding domain - - - 0.00000008364 62.0
SHD2_k127_4049263_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 583.0
SHD2_k127_4049263_1 PFAM LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002703 274.0
SHD2_k127_4049263_2 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000001159 259.0
SHD2_k127_4049263_3 by modhmm - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004091 254.0
SHD2_k127_4049263_4 Rhodanese Homology Domain - - - 0.0000000000000000000000000002409 120.0
SHD2_k127_4075006_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002469 273.0
SHD2_k127_4075006_1 Protein of unknown function (DUF1616) - - - 0.000000000000000000001085 106.0
SHD2_k127_4075006_2 Glycosyltransferase Family 4 - - - 0.0000000000002434 72.0
SHD2_k127_4076064_0 PFAM conserved K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 398.0
SHD2_k127_4076064_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 397.0
SHD2_k127_4076064_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001745 281.0
SHD2_k127_4087006_0 Archaeal Type IV pilin, N-terminal - - - 0.00000000000000006191 94.0
SHD2_k127_4102527_0 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 498.0
SHD2_k127_4102527_1 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000000000008739 201.0
SHD2_k127_4102527_2 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000000000000000000000000000000001283 173.0
SHD2_k127_4102527_3 PFAM ABC transporter K16786 - - 0.0000000000000000000000000000000000000000000004918 181.0
SHD2_k127_4102527_4 Histidine kinase - - - 0.0000004889 54.0
SHD2_k127_4104205_0 PFAM Cache, type 2 domain protein K02030 - - 2.989e-259 815.0
SHD2_k127_4104205_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 510.0
SHD2_k127_4104205_2 Domain of unknown function (DU1801) - - - 0.0000000000000167 75.0
SHD2_k127_4118664_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 464.0
SHD2_k127_4118664_1 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000449 259.0
SHD2_k127_4118664_2 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000000002372 151.0
SHD2_k127_4118664_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.00000000000000000000000003985 113.0
SHD2_k127_4129767_0 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 415.0
SHD2_k127_4129767_1 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000002067 147.0
SHD2_k127_4129767_2 Citrate transporter - - - 0.00000000000000000000000000000005673 140.0
SHD2_k127_4129767_3 Citrate transporter - - - 0.000000000000000000000001267 116.0
SHD2_k127_4129767_4 TIR domain - - - 0.0000000009761 65.0
SHD2_k127_4136628_0 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003141 591.0
SHD2_k127_4136628_1 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 527.0
SHD2_k127_4136628_2 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 331.0
SHD2_k127_4136628_3 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.00000000000000000000000000000000000000000004036 162.0
SHD2_k127_413794_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009533 260.0
SHD2_k127_413794_1 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000006659 90.0
SHD2_k127_4142080_0 SOS response associated peptidase (SRAP) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 289.0
SHD2_k127_4142080_1 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000001683 263.0
SHD2_k127_4142080_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000002376 236.0
SHD2_k127_4142080_3 InterPro IPR014922 - - - 0.00000000000000000000000289 108.0
SHD2_k127_4142080_4 Domain of unknown function (DU1801) - - - 0.000000000000000000001998 104.0
SHD2_k127_4142080_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000004877 81.0
SHD2_k127_4243927_0 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 536.0
SHD2_k127_4243927_1 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 511.0
SHD2_k127_4243927_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 362.0
SHD2_k127_4243927_3 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000786 260.0
SHD2_k127_4243927_4 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000005573 215.0
SHD2_k127_4243927_5 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000000000000000005164 150.0
SHD2_k127_4243927_6 Sodium/hydrogen exchanger family - - - 0.0000003519 58.0
SHD2_k127_4265839_0 PFAM GTP-binding protein HSR1-related K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005757 376.0
SHD2_k127_4265839_1 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000000000000000000000000000000000000000008532 199.0
SHD2_k127_4265839_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000004785 192.0
SHD2_k127_4265839_3 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000000000000000006389 152.0
SHD2_k127_4265839_4 ribosomal protein S15 K02956 - - 0.00000000000000000000000001007 112.0
SHD2_k127_4269236_0 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 326.0
SHD2_k127_4269236_1 KaiB K08481 - - 0.00000000000000000000000000000000994 133.0
SHD2_k127_4273876_0 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 421.0
SHD2_k127_4273876_1 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 343.0
SHD2_k127_4281353_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009552 558.0
SHD2_k127_4281353_1 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 354.0
SHD2_k127_4281353_2 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 359.0
SHD2_k127_4287847_0 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000001503 233.0
SHD2_k127_4287847_1 membrane protein (DUF2078) K08982 - - 0.00000000000000000000000000000000137 133.0
SHD2_k127_4287847_2 Prolyl oligopeptidase family - - - 0.000000009653 69.0
SHD2_k127_4288747_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 604.0
SHD2_k127_4288747_1 Uncharacterised protein family UPF0058 - - - 0.000000000000000000001083 96.0
SHD2_k127_4315791_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 5.741e-216 681.0
SHD2_k127_4315791_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 520.0
SHD2_k127_4315791_10 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.000000000007092 71.0
SHD2_k127_4315791_2 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 420.0
SHD2_k127_4315791_3 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 328.0
SHD2_k127_4315791_4 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006053 246.0
SHD2_k127_4315791_5 Belongs to the UPF0179 family K09730 - - 0.00000000000000000000000000000000000000000000000000000000000002554 218.0
SHD2_k127_4315791_6 Stage II sporulation protein M K06384 - - 0.00000000000000000000000000000000000006251 149.0
SHD2_k127_4315791_7 protein conserved in archaea K09723 - - 0.00000000000000000000000000001424 126.0
SHD2_k127_4315791_8 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000001982 115.0
SHD2_k127_4315791_9 metal-binding protein - - - 0.0000000000000000000000167 102.0
SHD2_k127_4363826_0 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.000000000000000000000000000000000000000006937 170.0
SHD2_k127_4363826_1 ABC-type transport system involved in cytochrome c biogenesis permease component K02195 - - 0.0000000000000000000000000000000000000008114 156.0
SHD2_k127_4373616_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 577.0
SHD2_k127_4373616_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 517.0
SHD2_k127_4373616_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 372.0
SHD2_k127_4373616_3 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000966 104.0
SHD2_k127_4374932_0 LOR SDH bifunctional enzyme conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 608.0
SHD2_k127_4374932_1 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 385.0
SHD2_k127_4374932_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000001607 242.0
SHD2_k127_4374932_3 SMART Elongator protein 3 MiaB NifB K06936 - - 0.000000000000000000000000000000000000000000000000000000000000000003139 237.0
SHD2_k127_4374932_4 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.0000000000000000000000000000000000000003096 157.0
SHD2_k127_4374932_5 - - - - 0.0000000000000000000001077 109.0
SHD2_k127_4374932_6 - - - - 0.000000000000000005501 85.0
SHD2_k127_4385528_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 519.0
SHD2_k127_4436652_0 COG0306 Phosphate sulphate permeases K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 349.0
SHD2_k127_4436652_1 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000001817 242.0
SHD2_k127_4436652_2 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000001357 201.0
SHD2_k127_4436652_3 PFAM PKD domain containing protein - - - 0.000000000000001174 88.0
SHD2_k127_4436652_4 - - - - 0.000006086 52.0
SHD2_k127_4436652_5 metallopeptidase activity - - - 0.0001242 44.0
SHD2_k127_4441425_0 PFAM Aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 488.0
SHD2_k127_4441425_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001931 295.0
SHD2_k127_4441425_2 VTC domain - - - 0.0000000000000000000000001064 117.0
SHD2_k127_4441425_3 Glutaredoxin - - - 0.0000000000000001547 89.0
SHD2_k127_4452223_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 1.671e-201 633.0
SHD2_k127_4452223_1 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 389.0
SHD2_k127_4452223_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006818 359.0
SHD2_k127_4452223_3 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 344.0
SHD2_k127_4452223_4 - - - - 0.000000000000000000000000000000000022 140.0
SHD2_k127_448940_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 392.0
SHD2_k127_448940_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.0000000000000002287 80.0
SHD2_k127_4495333_0 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001638 247.0
SHD2_k127_4576049_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.132e-218 684.0
SHD2_k127_4576049_1 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 394.0
SHD2_k127_4576049_2 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.000000000000000000000000000000000000000000000000000000000000001199 224.0
SHD2_k127_4576049_3 SMART cellulose binding type IV - - - 0.00000002416 63.0
SHD2_k127_4606928_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 429.0
SHD2_k127_4606928_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000001477 92.0
SHD2_k127_4606928_2 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000002578 60.0
SHD2_k127_4616700_0 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008073 281.0
SHD2_k127_4616700_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000000000000004676 196.0
SHD2_k127_4616700_2 TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000001981 167.0
SHD2_k127_4624734_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 475.0
SHD2_k127_4624734_1 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 447.0
SHD2_k127_4624734_10 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000003514 172.0
SHD2_k127_4624734_11 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000001072 108.0
SHD2_k127_4624734_12 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000009177 97.0
SHD2_k127_4624734_13 Protein of unknown function (DUF1294) - - - 0.00000000000006419 75.0
SHD2_k127_4624734_2 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 343.0
SHD2_k127_4624734_3 PFAM ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 337.0
SHD2_k127_4624734_4 neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 302.0
SHD2_k127_4624734_5 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000108 278.0
SHD2_k127_4624734_6 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001641 271.0
SHD2_k127_4624734_7 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002229 245.0
SHD2_k127_4624734_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000007342 227.0
SHD2_k127_4624734_9 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000002012 211.0
SHD2_k127_4641981_0 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 487.0
SHD2_k127_4641981_1 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 297.0
SHD2_k127_4787211_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 406.0
SHD2_k127_4787211_1 membrane-associated protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000004205 229.0
SHD2_k127_4787211_2 permease - - - 0.00000000000005072 72.0
SHD2_k127_481283_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.811e-202 633.0
SHD2_k127_481283_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009015 498.0
SHD2_k127_481283_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 404.0
SHD2_k127_481283_3 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 321.0
SHD2_k127_481283_4 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 299.0
SHD2_k127_481283_5 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000001829 267.0
SHD2_k127_4812897_0 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001053 283.0
SHD2_k127_4812897_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000004607 258.0
SHD2_k127_4812897_2 PFAM dihydropteroate synthase, DHPS - - - 0.00000000000000000000000000000000000000000000000000000001105 201.0
SHD2_k127_4812897_3 - - - - 0.000002219 50.0
SHD2_k127_4831048_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000009705 89.0
SHD2_k127_4831048_1 - - - - 0.0000000000002975 75.0
SHD2_k127_4831048_2 Domain of unknown function (DUF378) K09779 - - 0.0000000003883 64.0
SHD2_k127_4831048_3 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) K19091 - - 0.00000009362 55.0
SHD2_k127_4854221_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 400.0
SHD2_k127_4854221_1 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 346.0
SHD2_k127_4854221_2 - - - - 0.0000000000000000000000000000001972 126.0
SHD2_k127_4854221_3 signal transduction protein with CBS domains K07744 - - 0.00000000002146 64.0
SHD2_k127_4859029_0 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004377 474.0
SHD2_k127_4859029_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 370.0
SHD2_k127_4859029_2 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 345.0
SHD2_k127_4859029_3 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000004033 190.0
SHD2_k127_4859029_4 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.000000000000000000001524 93.0
SHD2_k127_4862882_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 1.369e-299 949.0
SHD2_k127_4862882_1 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008042 257.0
SHD2_k127_4862882_2 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000006158 186.0
SHD2_k127_4862882_3 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000001596 102.0
SHD2_k127_4881435_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 435.0
SHD2_k127_4881435_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006373 359.0
SHD2_k127_4881435_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 355.0
SHD2_k127_4881435_3 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000009389 208.0
SHD2_k127_4881435_4 TIGRFAM methionine-R-sulfoxide reductase K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000004037 191.0
SHD2_k127_4881435_5 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000006374 179.0
SHD2_k127_4881435_6 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000143 174.0
SHD2_k127_4881435_7 - - - - 0.0000000000000000001225 99.0
SHD2_k127_4911423_0 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 447.0
SHD2_k127_4911423_1 methanogen marker protein 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000186 261.0
SHD2_k127_4911472_0 PFAM type II secretion system protein E K07332 - - 6.425e-278 863.0
SHD2_k127_4911472_1 type II secretion system protein K07333 - - 1.402e-265 833.0
SHD2_k127_4911472_2 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 384.0
SHD2_k127_4911472_3 Pfam:KaiC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 332.0
SHD2_k127_4911472_4 PFAM TspO MBR family K05770 - - 0.00000000000000000000000000000000000000000008076 165.0
SHD2_k127_4911472_5 - - - - 0.000000000000001895 78.0
SHD2_k127_4946182_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 558.0
SHD2_k127_4946182_1 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005764 304.0
SHD2_k127_4946182_2 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000463 203.0
SHD2_k127_4946182_3 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000000000000002515 137.0
SHD2_k127_4971474_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000001503 131.0
SHD2_k127_4972667_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 589.0
SHD2_k127_4972667_1 PFAM ABC-1 domain protein K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 518.0
SHD2_k127_4972667_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 493.0
SHD2_k127_4972667_3 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 416.0
SHD2_k127_4972667_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 344.0
SHD2_k127_4972667_5 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000172 278.0
SHD2_k127_4972667_6 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000004767 239.0
SHD2_k127_4972667_7 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000008283 186.0
SHD2_k127_4972667_8 - - - - 0.00000000000000000000000000000000000000401 153.0
SHD2_k127_4972667_9 Belongs to the UPF0434 family - - - 0.0000000000000000001025 91.0
SHD2_k127_4992885_0 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 497.0
SHD2_k127_4992885_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534 - 3.6.3.3,3.6.3.5 0.0000000000000000000000000000000000000000000000000000000000001124 231.0
SHD2_k127_4992885_2 DGC domain - - - 0.0000000000000000000000000000000000002183 149.0
SHD2_k127_4992885_3 PFAM regulatory protein, ArsR K21903 - - 0.0000000000000000000000000000001199 127.0
SHD2_k127_4992885_4 TIGRFAM C_GCAxxG_C_C family - - - 0.000000000000000000000000000001632 127.0
SHD2_k127_4992885_5 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.0000000000000000000000002 113.0
SHD2_k127_4992885_6 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000004244 97.0
SHD2_k127_4992885_7 Protease prsW family - - - 0.00000000000000001801 83.0
SHD2_k127_50039_0 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006736 261.0
SHD2_k127_50039_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000003708 155.0
SHD2_k127_50039_2 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000009607 157.0
SHD2_k127_50039_3 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000002636 164.0
SHD2_k127_5075269_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001094 284.0
SHD2_k127_5075269_1 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000005715 189.0
SHD2_k127_5075269_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000008739 124.0
SHD2_k127_5075269_3 toxin-antitoxin pair type II binding - - - 0.0000000000000000258 84.0
SHD2_k127_5081307_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 437.0
SHD2_k127_5081307_1 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000001414 115.0
SHD2_k127_5081307_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0001651 44.0
SHD2_k127_5149679_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1268.0
SHD2_k127_5149679_1 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 334.0
SHD2_k127_5149679_2 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.000000000000000000000001212 106.0
SHD2_k127_5149679_3 lactoylglutathione lyase activity - - - 0.0000000000000000000001864 111.0
SHD2_k127_5149679_4 Protein of unknown function (DUF541) K09807 - - 0.0000000006203 68.0
SHD2_k127_5154418_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 529.0
SHD2_k127_5154418_1 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 454.0
SHD2_k127_5154418_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 332.0
SHD2_k127_5154418_3 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000000185 95.0
SHD2_k127_5154671_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 604.0
SHD2_k127_5154671_1 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 315.0
SHD2_k127_5154671_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000002737 151.0
SHD2_k127_5159374_0 DEAD DEAH box helicase K06877 - - 3.386e-247 787.0
SHD2_k127_5159374_1 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000000000000001857 207.0
SHD2_k127_5159374_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000003577 64.0
SHD2_k127_5179401_0 PFAM ABC transporter K00400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 321.0
SHD2_k127_5179401_1 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000004314 233.0
SHD2_k127_5192962_0 PHP domain protein K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003687 274.0
SHD2_k127_5192962_1 metal-dependent phosphoesterases (PHP family) K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000008362 195.0
SHD2_k127_5203246_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001072 235.0
SHD2_k127_5203246_1 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000001181 197.0
SHD2_k127_5203246_2 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000003336 70.0
SHD2_k127_5203246_4 ChaB K06197 - - 0.00000005527 57.0
SHD2_k127_5265854_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000495 527.0
SHD2_k127_5265854_1 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 423.0
SHD2_k127_5265854_2 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 384.0
SHD2_k127_5265854_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001562 283.0
SHD2_k127_5265854_4 Belongs to the UPF0305 family - - - 0.00000000000000000000000000000000000000000000000000000000000000004083 236.0
SHD2_k127_5265854_5 Functions by promoting the formation of the first peptide bond K03263 - - 0.0000000000000000000000000000000000000000000000000000005246 202.0
SHD2_k127_5265854_6 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000001938 95.0
SHD2_k127_5265854_7 - - - - 0.0000000000000000002721 91.0
SHD2_k127_5272295_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.076e-232 728.0
SHD2_k127_5272295_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006217 608.0
SHD2_k127_5272295_10 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.000000000000000000000000000000000000002855 147.0
SHD2_k127_5272295_11 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.000000000000000000000000001122 113.0
SHD2_k127_5272295_12 helicase activity K06915 - - 0.000000000000000000000001019 110.0
SHD2_k127_5272295_13 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000004262 83.0
SHD2_k127_5272295_2 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 588.0
SHD2_k127_5272295_3 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 531.0
SHD2_k127_5272295_4 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 512.0
SHD2_k127_5272295_5 Involved in regulation of DNA replication K10725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 462.0
SHD2_k127_5272295_6 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009289 453.0
SHD2_k127_5272295_7 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 394.0
SHD2_k127_5272295_8 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002365 278.0
SHD2_k127_5272295_9 PFAM regulatory protein, ArsR K07721 - - 0.000000000000000000000000000000000000000000000004609 195.0
SHD2_k127_5272966_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1601.0
SHD2_k127_5272966_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1100.0
SHD2_k127_5272966_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004981 452.0
SHD2_k127_5272966_3 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 330.0
SHD2_k127_5286864_0 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 441.0
SHD2_k127_5286864_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000007994 253.0
SHD2_k127_5286864_2 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000000000000003493 182.0
SHD2_k127_5286864_3 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000007666 176.0
SHD2_k127_5286864_4 acetylornithine aminotransferase K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.00002301 49.0
SHD2_k127_5290729_0 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.478e-217 681.0
SHD2_k127_5290729_1 methanogenesis marker protein 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 468.0
SHD2_k127_5290729_2 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001019 271.0
SHD2_k127_5290729_3 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004207 246.0
SHD2_k127_5290729_4 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000001836 181.0
SHD2_k127_5290729_5 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000000000000000964 171.0
SHD2_k127_5308295_0 Transport of potassium into the cell K03549 - - 3.862e-237 751.0
SHD2_k127_5308295_1 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003985 361.0
SHD2_k127_5308295_2 NADPH-dependent FMN reductase - - - 0.0000000000000000005476 87.0
SHD2_k127_5318120_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.802e-257 803.0
SHD2_k127_5318120_1 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 289.0
SHD2_k127_5318120_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 291.0
SHD2_k127_5318120_3 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000008665 163.0
SHD2_k127_5318120_4 - - - - 0.00000000000002403 75.0
SHD2_k127_5324953_0 Belongs to the RtcB family K14415 - 6.5.1.3 6.031e-210 662.0
SHD2_k127_5324953_1 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 382.0
SHD2_k127_5324953_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002349 228.0
SHD2_k127_5324953_3 Alkaline phosphatase homologues K01077 GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564 3.1.3.1 0.000000000000000000000000000000000000000000000000000000002359 220.0
SHD2_k127_5324953_4 Protein of unknown function (DUF2551) - - - 0.000000000000000000000000000000002754 133.0
SHD2_k127_5324953_5 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000001479 125.0
SHD2_k127_5324953_6 - - - - 0.000000000000000000000002993 104.0
SHD2_k127_5367898_0 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006578 475.0
SHD2_k127_5367898_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 460.0
SHD2_k127_5367898_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 292.0
SHD2_k127_5367898_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000122 248.0
SHD2_k127_5367898_4 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000008126 218.0
SHD2_k127_5367898_5 Pfam:Gp37_Gp68 - - - 0.000000000000000000000000000000000000000000000000000000789 200.0
SHD2_k127_5367898_6 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000001854 194.0
SHD2_k127_5367898_7 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000001211 156.0
SHD2_k127_5367898_8 - - - - 0.000000001026 59.0
SHD2_k127_5367898_9 - K06193 - - 0.000001063 62.0
SHD2_k127_5408284_0 - - - - 0.00000000000000000000000000000742 133.0
SHD2_k127_5408284_1 Glycoside hydrolase family 28 - - - 0.000000000000000000000001769 119.0
SHD2_k127_5427421_0 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009926 390.0
SHD2_k127_5427421_1 Matrixin - - - 0.00000000000000000000000000000001866 138.0
SHD2_k127_5427421_2 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.00004862 52.0
SHD2_k127_5428388_0 CBS domain containing protein K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 477.0
SHD2_k127_5428388_1 Protein of unknown function (DUF2769) - - - 0.000000000000000001618 88.0
SHD2_k127_5428388_2 - - - - 0.00000000000005212 79.0
SHD2_k127_5428388_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03471 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000003885 65.0
SHD2_k127_5455029_0 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 496.0
SHD2_k127_5455029_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000086 486.0
SHD2_k127_5455029_2 Molybdate transporter of MFS superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005225 329.0
SHD2_k127_5455029_3 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002182 233.0
SHD2_k127_5455029_4 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000002211 168.0
SHD2_k127_5455029_5 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000001248 141.0
SHD2_k127_5455029_6 SpoVT / AbrB like domain - - - 0.00000000000000000000000000000001792 128.0
SHD2_k127_5471633_0 parallel beta-helix repeat - - - 0.0000000000000000000000000000000000000000000000000000000000001098 233.0
SHD2_k127_5471633_1 parallel beta-helix repeat - - - 0.00000000000000000000000000000000000000000000000000000000002199 222.0
SHD2_k127_5471633_2 PFAM PKD domain containing protein - - - 0.0000000000000000003312 102.0
SHD2_k127_5474993_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 4.626e-194 614.0
SHD2_k127_5474993_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000002334 244.0
SHD2_k127_5474993_2 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000002998 147.0
SHD2_k127_5474993_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000002206 93.0
SHD2_k127_5478130_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 492.0
SHD2_k127_5478130_1 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 464.0
SHD2_k127_5478130_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 373.0
SHD2_k127_5478130_3 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.0000000000000241 83.0
SHD2_k127_5478130_4 - - - - 0.0000000000001942 80.0
SHD2_k127_5478852_0 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 342.0
SHD2_k127_5503968_0 signal transduction histidine kinase - - - 2.557e-228 749.0
SHD2_k127_5503968_1 Pfam:KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 602.0
SHD2_k127_5503968_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006707 308.0
SHD2_k127_5503968_3 Pfam:KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007323 269.0
SHD2_k127_5503968_4 KaiB K08481 - - 0.000000000000000000000000000000000000000000001498 170.0
SHD2_k127_5503968_5 KaiB K08481 - - 0.00000000000000000000000000001965 121.0
SHD2_k127_5503968_6 KaiB K08481 - - 0.0000000000000000000000000001708 132.0
SHD2_k127_5503968_7 KaiB K08481 - - 0.00000000002351 68.0
SHD2_k127_5516146_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 598.0
SHD2_k127_5516146_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 571.0
SHD2_k127_5516146_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006818 381.0
SHD2_k127_5516146_3 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000008334 256.0
SHD2_k127_5516146_4 PFAM PRC-barrel domain - - - 0.00000000000000000000000000000000000000004974 153.0
SHD2_k127_5516146_5 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000003556 120.0
SHD2_k127_5516146_6 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000003499 112.0
SHD2_k127_55416_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 484.0
SHD2_k127_55416_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 365.0
SHD2_k127_55416_10 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000006293 126.0
SHD2_k127_55416_11 PFAM NHL repeat containing protein - - - 0.00000000000000000000009354 111.0
SHD2_k127_55416_12 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.000000000000000000353 88.0
SHD2_k127_55416_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001255 251.0
SHD2_k127_55416_3 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001152 243.0
SHD2_k127_55416_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000000000001464 236.0
SHD2_k127_55416_5 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000000000000002555 222.0
SHD2_k127_55416_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000003735 218.0
SHD2_k127_55416_7 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000002339 197.0
SHD2_k127_55416_8 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.00000000000000000000000000000000000000000000004701 171.0
SHD2_k127_55416_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.00000000000000000000000000000002642 126.0
SHD2_k127_5548853_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 601.0
SHD2_k127_5568599_0 PFAM Yip1 domain - - - 0.0000000000001293 76.0
SHD2_k127_557067_0 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000000000000000000000000000000000000000000000000000000000185 214.0
SHD2_k127_557067_1 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000005333 196.0
SHD2_k127_557067_2 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000001527 160.0
SHD2_k127_5616802_0 CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 529.0
SHD2_k127_5616802_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001891 268.0
SHD2_k127_5616802_10 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000009813 85.0
SHD2_k127_5616802_2 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000005588 234.0
SHD2_k127_5616802_3 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.00000000000000000000000000000000000000000000000000000000000000009381 224.0
SHD2_k127_5616802_4 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.000000000000000000000000000000000000000000000000000000000000002449 225.0
SHD2_k127_5616802_5 Belongs to the PDCD5 family K06875 - - 0.0000000000000000000000000000000000000000008244 161.0
SHD2_k127_5616802_6 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.00000000000000000000000000000000000000003414 155.0
SHD2_k127_5616802_7 CRS1_YhbY K07574 - - 0.00000000000000000000000003212 109.0
SHD2_k127_5616802_8 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.0000000000000000000000007509 108.0
SHD2_k127_5616802_9 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000002168 97.0
SHD2_k127_5638799_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 323.0
SHD2_k127_5638799_1 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000002647 186.0
SHD2_k127_5652643_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.265e-229 728.0
SHD2_k127_5652643_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 478.0
SHD2_k127_5652643_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000000000000000000000000000000001103 201.0
SHD2_k127_5652643_3 - - - - 0.00000000000000000000000000000000000000000000005164 173.0
SHD2_k127_5652643_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000000000000000000000000000000000006707 152.0
SHD2_k127_5652643_5 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0000000000000000000000000000000071 129.0
SHD2_k127_5652643_6 H subunit K02107 - - 0.00000000000000000000000000000001312 130.0
SHD2_k127_5652643_7 - - - - 0.0000000000000004758 79.0
SHD2_k127_5660729_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 477.0
SHD2_k127_5660729_1 Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000001068 178.0
SHD2_k127_5678884_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 584.0
SHD2_k127_5678884_1 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008436 321.0
SHD2_k127_5678884_2 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000005635 161.0
SHD2_k127_5678884_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.0000000000000000000000000000002567 124.0
SHD2_k127_5678884_4 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000000000000004411 118.0
SHD2_k127_5678884_5 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000000000005738 117.0
SHD2_k127_5678884_6 Large family of predicted nucleotide-binding domains K07158 - - 0.0000000000000000000002734 111.0
SHD2_k127_5678884_7 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000006496 89.0
SHD2_k127_5683421_0 PFAM PKD domain containing protein - - - 3.61e-221 709.0
SHD2_k127_5683421_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000003162 266.0
SHD2_k127_5683421_2 response regulator, receiver K03413,K07662,K07667 - - 0.00000000000000000000000000000000003556 139.0
SHD2_k127_5683421_3 - - - - 0.000000000000000001862 90.0
SHD2_k127_5687467_0 PFAM ABC transporter K00400 - - 4.33e-272 847.0
SHD2_k127_5702730_0 Peptidase M56 - - - 0.0000000000000000000000000000001763 141.0
SHD2_k127_5702730_1 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000007778 53.0
SHD2_k127_5704351_0 PFAM Glycosyl transferase family 2 - - - 0.0 2072.0
SHD2_k127_5704351_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 594.0
SHD2_k127_5719171_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 594.0
SHD2_k127_5719171_1 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 366.0
SHD2_k127_5719171_2 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 327.0
SHD2_k127_5719171_3 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 300.0
SHD2_k127_5719171_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004798 296.0
SHD2_k127_5719171_5 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000197 106.0
SHD2_k127_5719171_6 PBS lyase HEAT-like repeat - - - 0.000000006512 61.0
SHD2_k127_572100_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 460.0
SHD2_k127_572100_1 Conserved region in glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007454 321.0
SHD2_k127_572100_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000829 146.0
SHD2_k127_5730805_0 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 1.126e-238 755.0
SHD2_k127_5730805_1 PFAM Radical SAM domain protein K06871 - - 0.000000000000000000000001647 104.0
SHD2_k127_5730805_2 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000003761 116.0
SHD2_k127_5734018_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 3.803e-213 669.0
SHD2_k127_5734018_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 9.621e-196 615.0
SHD2_k127_5734018_2 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004611 290.0
SHD2_k127_5742796_0 ABC transporter K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 357.0
SHD2_k127_5742796_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 348.0
SHD2_k127_5742796_2 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 302.0
SHD2_k127_5742796_3 amino acid ABC transporter K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 287.0
SHD2_k127_5742796_4 Amino acid ABC transporter substrate-binding protein, PAAT family K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008474 278.0
SHD2_k127_5751491_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 298.0
SHD2_k127_5751491_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000003777 181.0
SHD2_k127_5791805_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 415.0
SHD2_k127_5791805_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 340.0
SHD2_k127_5791805_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 341.0
SHD2_k127_5791805_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 312.0
SHD2_k127_5791805_4 Molybdopterin converting factor K03635 - 2.8.1.12 0.00000000000000000000000000000000000121 144.0
SHD2_k127_5791805_5 Transcriptional regulator K07108 - - 0.000000000000000000000000004464 117.0
SHD2_k127_5791805_6 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000005351 78.0
SHD2_k127_5822455_0 Fasciclin domain protein - GO:0005575,GO:0005576,GO:0005615,GO:0044421 - 0.00000000000000000000000000000000001593 143.0
SHD2_k127_5822455_1 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000009281 83.0
SHD2_k127_5822455_2 Protein of unknown function (DUF475) K09799 - - 0.000000000000003979 75.0
SHD2_k127_5834702_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 600.0
SHD2_k127_5834702_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 446.0
SHD2_k127_5834702_2 ZPR1-related zinc finger protein K06874 - - 0.00000000000000000000000000000000000000000000000000000000000004734 220.0
SHD2_k127_5834702_3 Pfam:DUF552 K09152 - - 0.000000000000000000000000000000000000000000000000000000000005885 213.0
SHD2_k127_5834702_4 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000001905 175.0
SHD2_k127_5834702_5 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000006992 162.0
SHD2_k127_5834702_6 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 0.0000000000006674 81.0
SHD2_k127_5838840_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 535.0
SHD2_k127_5838840_1 Cache_2 - - - 0.000000000000000000000000001618 115.0
SHD2_k127_5838840_2 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000002963 121.0
SHD2_k127_5838840_3 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.000000000000000002873 89.0
SHD2_k127_5838840_4 GYD domain - - - 0.000000000000000003357 87.0
SHD2_k127_5922219_0 Archaeal Nre, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003871 520.0
SHD2_k127_5922219_1 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000000000000000000000000000000000000000000001197 182.0
SHD2_k127_5951990_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 499.0
SHD2_k127_5987941_0 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000992 249.0
SHD2_k127_5987941_1 Thioredoxin - - - 0.0000000000000000000000000000000000003799 144.0
SHD2_k127_5994610_0 parallel beta-helix repeat - - - 0.00000000000000000000000000000000000000000000001776 186.0
SHD2_k127_5994610_1 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000003018 102.0
SHD2_k127_6011000_0 in RNase L inhibitor, RLI K06174 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 490.0
SHD2_k127_6011000_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 282.0
SHD2_k127_6011000_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000001593 214.0
SHD2_k127_603169_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005137 572.0
SHD2_k127_6057672_0 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008059 248.0
SHD2_k127_6057672_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000003658 186.0
SHD2_k127_6057672_2 PDGLE domain K02009 - - 0.0006305 51.0
SHD2_k127_6057672_3 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.0006689 46.0
SHD2_k127_6093754_0 metallopeptidase activity K20276 - - 0.00000000000000000000000000000000000000000000008439 194.0
SHD2_k127_6093754_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000004522 149.0
SHD2_k127_6151662_0 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004891 358.0
SHD2_k127_6151662_1 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000002099 210.0
SHD2_k127_6151662_2 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000008208 201.0
SHD2_k127_6163348_0 Predicted membrane protein (DUF2206) - - - 2.264e-293 919.0
SHD2_k127_6163348_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 5.523e-196 622.0
SHD2_k127_6163348_2 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 429.0
SHD2_k127_6163348_3 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 430.0
SHD2_k127_6163348_4 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008634 273.0
SHD2_k127_6163348_5 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000000005445 211.0
SHD2_k127_6163348_6 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000000001291 194.0
SHD2_k127_6163348_7 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000003528 194.0
SHD2_k127_6163348_8 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000003342 133.0
SHD2_k127_6163348_9 chorismate mutase K04093 - 5.4.99.5 0.0000000000000000000000007207 108.0
SHD2_k127_6177062_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.822e-218 681.0
SHD2_k127_6177062_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000003928 219.0
SHD2_k127_6261010_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 4.68e-216 678.0
SHD2_k127_6261010_1 Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000000000000000001338 117.0
SHD2_k127_6261010_2 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000002107 115.0
SHD2_k127_6269190_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 598.0
SHD2_k127_6269190_1 - - - - 0.0000000000000006159 78.0
SHD2_k127_6275686_0 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 444.0
SHD2_k127_6275686_1 - - - - 0.00000000000000000000005019 104.0
SHD2_k127_6275686_2 Ferredoxin K05337 - - 0.000000000000000000001587 96.0
SHD2_k127_6275686_3 PFAM PKD domain containing protein - - - 0.000000000000000002713 100.0
SHD2_k127_6276796_0 PFAM Radical SAM domain protein K06937 - - 3.194e-235 737.0
SHD2_k127_6276796_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 563.0
SHD2_k127_6276796_2 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 436.0
SHD2_k127_6276796_3 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005514 323.0
SHD2_k127_6276796_4 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000000000000000000005596 204.0
SHD2_k127_6276796_5 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000003799 198.0
SHD2_k127_6276796_6 Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000002904 111.0
SHD2_k127_6295874_0 acid binding OB-fold tRNA helicase-type K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 577.0
SHD2_k127_6295874_1 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004722 287.0
SHD2_k127_6346498_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.566e-226 711.0
SHD2_k127_6346498_1 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 404.0
SHD2_k127_6346498_2 KilA-N - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 336.0
SHD2_k127_6346498_3 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000001786 229.0
SHD2_k127_6346498_4 - - - - 0.00000000000000000000000000000000000000000000000000000001564 202.0
SHD2_k127_6346498_5 Pas domain - - - 0.00000000000000000000000000000000000000000000000000001441 211.0
SHD2_k127_6346498_6 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000000000000000000004065 143.0
SHD2_k127_6346498_7 PFAM Tetratricopeptide repeat - - - 0.000000000001187 76.0
SHD2_k127_6346498_8 Tetratricopeptide repeat - - - 0.0001758 50.0
SHD2_k127_6356081_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 613.0
SHD2_k127_6356081_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 369.0
SHD2_k127_6356081_2 Sulfide dehydrogenase (Flavoprotein) subunit SudB K00528,K02823 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000003164 173.0
SHD2_k127_638595_0 Belongs to the MCM family K10726 - - 1.603e-301 933.0
SHD2_k127_6430844_0 peptidyl-tyrosine sulfation - - - 0.0 1427.0
SHD2_k127_6430844_1 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 3.009e-221 691.0
SHD2_k127_6430844_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 465.0
SHD2_k127_6430844_3 transcription termination protein NusA K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008442 244.0
SHD2_k127_6430844_4 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.0000000000000000000000000000000000000000000000000000000000000003507 230.0
SHD2_k127_6430844_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000002373 155.0
SHD2_k127_6430844_6 PFAM ribosomal protein L7Ae L30e S12e Gadd45 K02908 - - 0.00000000000000000000000000000000001079 138.0
SHD2_k127_6430844_7 A G-specific K03575 - - 0.00000000000000000000000000000000005089 137.0
SHD2_k127_6430844_8 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000000000000000001761 127.0
SHD2_k127_6454245_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009325 566.0
SHD2_k127_6454245_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 430.0
SHD2_k127_6454245_10 KTSC domain - - - 0.0000002728 63.0
SHD2_k127_6454245_11 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000003386 59.0
SHD2_k127_6454245_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 404.0
SHD2_k127_6454245_3 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 323.0
SHD2_k127_6454245_4 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001111 293.0
SHD2_k127_6454245_5 TIGRFAM Por secretion system C-terminal sorting domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005488 265.0
SHD2_k127_6454245_6 Glycoside hydrolase family 28 - - - 0.0000000000000000000000000000000000000000000003912 184.0
SHD2_k127_6454245_7 Periplasmic copper-binding protein (NosD) - - - 0.0000000000000000000000000000000000000002165 154.0
SHD2_k127_6454245_8 Flavodoxin - - - 0.000000000000000000000000000000000000002713 155.0
SHD2_k127_6454245_9 PFAM NHL repeat containing protein - - - 0.00000000000000000000006068 114.0
SHD2_k127_6467030_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 6.404e-231 723.0
SHD2_k127_6467030_1 PFAM Cys Met metabolism K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 469.0
SHD2_k127_6467030_2 Cysteine synthase A K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 453.0
SHD2_k127_6467030_3 Cysteine desulfurase K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 326.0
SHD2_k127_6468610_0 Glycoside hydrolase family 28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 610.0
SHD2_k127_6468610_1 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 383.0
SHD2_k127_6468610_2 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008608 332.0
SHD2_k127_6474168_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 5.355e-314 970.0
SHD2_k127_6474168_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 510.0
SHD2_k127_6474168_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000001007 110.0
SHD2_k127_6474168_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000002504 104.0
SHD2_k127_6515979_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 481.0
SHD2_k127_6515979_1 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 311.0
SHD2_k127_6515979_2 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000872 132.0
SHD2_k127_6515979_3 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000002116 107.0
SHD2_k127_6515979_4 protein conserved in archaea K09746 - - 0.00000000000000000001246 101.0
SHD2_k127_6515979_5 DEAD DEAH box helicase domain protein K03724 - - 0.0005303 44.0
SHD2_k127_6527253_0 PFAM Glycoside hydrolase 15-related - - - 7.371e-197 634.0
SHD2_k127_6527253_1 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 615.0
SHD2_k127_6527253_2 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 307.0
SHD2_k127_6527253_3 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000002014 198.0
SHD2_k127_6527253_4 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000000009485 152.0
SHD2_k127_6580749_0 stage II sporulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 315.0
SHD2_k127_6580749_1 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000004427 103.0
SHD2_k127_6580749_2 SAM dependent carboxyl methyltransferase - - - 0.000000000000000002444 97.0
SHD2_k127_6588588_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 424.0
SHD2_k127_6588588_1 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000722 220.0
SHD2_k127_6588588_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000003107 93.0
SHD2_k127_6588588_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000003442 63.0
SHD2_k127_6594263_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 439.0
SHD2_k127_6594263_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 433.0
SHD2_k127_6594263_2 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000005524 173.0
SHD2_k127_6595564_0 Aldo/keto reductase family K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 464.0
SHD2_k127_6595564_1 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000002281 213.0
SHD2_k127_6595564_2 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000008632 221.0
SHD2_k127_6595564_3 PFAM ribonuclease II K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000006972 193.0
SHD2_k127_6595564_4 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000008071 140.0
SHD2_k127_6595564_5 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000000000000005764 130.0
SHD2_k127_6595564_6 multicopper oxidases - - - 0.0000000000000000000000000009967 112.0
SHD2_k127_6619793_0 Lon protease (S16) C-terminal proteolytic domain - - - 0.00000000000000000000000000005702 117.0
SHD2_k127_6619793_1 COG1361 S-layer domain - - - 0.00000000000000000000003941 108.0
SHD2_k127_6619793_2 Helix-turn-helix domain K07729 - - 0.00000000000001159 78.0
SHD2_k127_6619793_3 membrane protein (DUF2178) - - - 0.00007035 49.0
SHD2_k127_6620936_0 DNA methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 385.0
SHD2_k127_6620936_1 PFAM AAA ATPase central domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 378.0
SHD2_k127_6620936_2 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 321.0
SHD2_k127_6620936_3 Oxidoreductase, molybdopterin binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000006071 237.0
SHD2_k127_6620936_4 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000002674 134.0
SHD2_k127_6620936_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000000000000003067 119.0
SHD2_k127_6620936_6 - - - - 0.00000000001657 72.0
SHD2_k127_665789_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1501.0
SHD2_k127_665789_1 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 0.0000000000000000000000000000000000000189 147.0
SHD2_k127_665789_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000001803 126.0
SHD2_k127_6662545_0 Glycoside hydrolase family 28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 566.0
SHD2_k127_6662545_1 SMART Elongator protein 3 MiaB NifB K22226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 425.0
SHD2_k127_6662545_2 - - - - 0.000000000000000000000000000000003827 132.0
SHD2_k127_6662545_3 SMART regulatory protein AsnC Lrp family K22225 - - 0.000000000000000000000000000000004713 134.0
SHD2_k127_6662545_4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.00000000000000001477 95.0
SHD2_k127_6662545_5 PspC domain K03973 - - 0.0000000000000001247 83.0
SHD2_k127_6662545_6 COG1522 Transcriptional regulators - - - 0.00000000000005867 73.0
SHD2_k127_6674849_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006457 296.0
SHD2_k127_6674849_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002428 247.0
SHD2_k127_6674849_2 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000002322 180.0
SHD2_k127_6674849_3 Belongs to the UPF0216 family K09737 - - 0.000000000000000000000000007624 118.0
SHD2_k127_6674849_4 YHS domain - - - 0.00000000000000000142 86.0
SHD2_k127_6674849_5 Glycosyl transferase family 2 - - - 0.000000000001242 77.0
SHD2_k127_6684405_0 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 337.0
SHD2_k127_6684405_1 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000000000000000000000001269 222.0
SHD2_k127_6684405_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000001185 152.0
SHD2_k127_6684405_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000003499 93.0
SHD2_k127_6704297_0 catalase activity K03781 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.6 5.507e-275 852.0
SHD2_k127_6704297_1 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000001342 168.0
SHD2_k127_6704297_2 divalent heavy-metal cations transporter K07238 - - 0.0000000000000004197 79.0
SHD2_k127_6710129_0 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000000003221 179.0
SHD2_k127_6710129_1 ATP cone domain - - - 0.000000000000000001093 89.0
SHD2_k127_6717525_0 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 444.0
SHD2_k127_6717525_1 TGS domain protein K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 436.0
SHD2_k127_6717525_2 - - - - 0.0000000000000000000000000000000000000000002654 160.0
SHD2_k127_6717525_3 archaeal coiled-coil protein - - - 0.0000000000000000000000000000000000000004489 149.0
SHD2_k127_6743098_0 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 567.0
SHD2_k127_6743098_1 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001172 268.0
SHD2_k127_6743098_2 PFAM regulatory protein AsnC Lrp family - - - 0.00000000000000000000000000000000000000000000000000000001985 201.0
SHD2_k127_6752643_0 metallopeptidase activity - - - 1.104e-252 807.0
SHD2_k127_6752643_1 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000001816 230.0
SHD2_k127_6752643_2 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000004684 248.0
SHD2_k127_6752643_3 PFAM phosphoesterase, PA-phosphatase related K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.00000000000000000000000000000000000005266 155.0
SHD2_k127_6754457_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 394.0
SHD2_k127_6754457_1 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 316.0
SHD2_k127_6754457_2 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 324.0
SHD2_k127_6754457_3 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004821 268.0
SHD2_k127_6754457_4 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001809 254.0
SHD2_k127_6754457_5 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003155 235.0
SHD2_k127_6754457_6 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000005519 199.0
SHD2_k127_6754457_7 Helix-turn-helix domain - - - 0.00000000000000000000000000000002136 130.0
SHD2_k127_6787784_0 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 412.0
SHD2_k127_6787784_1 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 318.0
SHD2_k127_6787784_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000007152 214.0
SHD2_k127_6787784_3 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000000004039 166.0
SHD2_k127_6787784_4 PFAM PKD domain containing protein - - - 0.000000000000000000002916 106.0
SHD2_k127_686964_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 2.804e-230 727.0
SHD2_k127_686964_1 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 577.0
SHD2_k127_686964_2 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 315.0
SHD2_k127_686964_3 COG1045 Serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000003644 246.0
SHD2_k127_686964_4 COG0526 Thiol-disulfide isomerase and thioredoxins K03671 - - 0.00000000000000000000000000000000000000003899 155.0
SHD2_k127_686964_5 DEAD DEAH box helicase K03724 - - 0.000000000000000000000001276 107.0
SHD2_k127_6936801_0 PFAM NADH Ubiquinone plastoquinone (complex I) K14086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 495.0
SHD2_k127_6936801_1 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000008968 165.0
SHD2_k127_6936801_2 PFAM HEPN domain - - - 0.000000003503 63.0
SHD2_k127_6959754_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004477 572.0
SHD2_k127_6959754_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009878 367.0
SHD2_k127_6959754_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000001376 273.0
SHD2_k127_6959754_3 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000172 281.0
SHD2_k127_6959754_4 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002734 232.0
SHD2_k127_6959754_5 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.0000000000000000000000000000000007961 134.0
SHD2_k127_6959754_6 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.00000000000000000000002393 100.0
SHD2_k127_6959754_7 PBS lyase HEAT-like repeat - - - 0.0000004448 60.0
SHD2_k127_7003744_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 591.0
SHD2_k127_7003744_1 SMART zinc finger, CDGSH-type domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007949 354.0
SHD2_k127_7003744_2 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008519 252.0
SHD2_k127_7003744_3 PHP-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000385 246.0
SHD2_k127_7003744_4 - - - - 0.000000000000000000000000000000000000000000008724 177.0
SHD2_k127_7003744_5 - - - - 0.000000007842 63.0
SHD2_k127_7023991_0 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 492.0
SHD2_k127_7023991_1 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 342.0
SHD2_k127_7023991_2 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.000000000000000000000000000000000000000000002666 166.0
SHD2_k127_7023991_3 Protein of unknown function (DUF447) K09154 - - 0.0000000000000000000000000000000000000000001797 170.0
SHD2_k127_7069160_0 ATPases associated with a variety of cellular activities K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 347.0
SHD2_k127_7069160_1 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000009564 224.0
SHD2_k127_7069160_2 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000001233 216.0
SHD2_k127_7069160_3 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000007667 238.0
SHD2_k127_7069160_4 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000005356 212.0
SHD2_k127_7069160_5 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000003675 207.0
SHD2_k127_7069160_6 - - - - 0.00000000000000000000000000000000000000000000000000003658 190.0
SHD2_k127_706977_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 1.122e-311 959.0
SHD2_k127_706977_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 298.0
SHD2_k127_706977_2 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000002724 240.0
SHD2_k127_706977_3 COG1881 Phospholipid-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000313 183.0
SHD2_k127_7072844_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006913 330.0
SHD2_k127_7072844_2 - - - - 0.000000000000000000000000009834 119.0
SHD2_k127_7072844_3 STAS-like domain of unknown function (DUF4325) - - - 0.00004521 54.0
SHD2_k127_7127308_0 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000006061 205.0
SHD2_k127_7127308_1 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.00000000000004329 74.0
SHD2_k127_7127308_2 Alpha/beta hydrolase family - - - 0.00000002173 61.0
SHD2_k127_7127308_3 4Fe-4S binding domain - - - 0.00001774 47.0
SHD2_k127_7131515_0 TIGRFAM acetate--CoA ligase K01895 - 6.2.1.1 1.795e-201 635.0
SHD2_k127_7131515_1 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 321.0
SHD2_k127_7131947_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 454.0
SHD2_k127_7131947_1 PFAM CRISPR-associated protein TM1812 K19143 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002206 260.0
SHD2_k127_7131947_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001509 246.0
SHD2_k127_7131947_3 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000002823 213.0
SHD2_k127_7131947_4 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000001433 149.0
SHD2_k127_7131947_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000002331 118.0
SHD2_k127_7131947_6 Short repeat of unknown function (DUF308) - - - 0.00000000000000000001586 104.0
SHD2_k127_7131947_7 TIGRFAM PAS sensor protein - - - 0.0003791 49.0
SHD2_k127_7160247_0 divalent heavy-metal cations transporter K07238 - - 0.0000000000000000000000000000000000000000000000313 181.0
SHD2_k127_7160247_1 Glycoside hydrolase family 28 - - - 0.000000000000000000000000008883 126.0
SHD2_k127_7161487_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 486.0
SHD2_k127_7161487_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004899 404.0
SHD2_k127_7161487_2 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 381.0
SHD2_k127_7161487_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 331.0
SHD2_k127_7161487_4 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 295.0
SHD2_k127_7161487_5 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002904 249.0
SHD2_k127_7162302_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 598.0
SHD2_k127_7162302_1 L-lactate permease K03303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 358.0
SHD2_k127_7162302_2 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007379 250.0
SHD2_k127_7162302_3 redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000000000001804 138.0
SHD2_k127_7162302_4 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000001248 139.0
SHD2_k127_7162302_5 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000000000000002477 111.0
SHD2_k127_719395_0 Protein of unknown function (DUF475) K09799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 437.0
SHD2_k127_719395_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009526 273.0
SHD2_k127_719395_2 COG2335 Secreted and surface protein containing fasciclin-like repeats K19519 - - 0.000000000000000000000000000000000001841 155.0
SHD2_k127_719395_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000004437 115.0
SHD2_k127_7212811_0 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 523.0
SHD2_k127_7212811_1 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 385.0
SHD2_k127_7212811_2 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 303.0
SHD2_k127_7276180_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004022 277.0
SHD2_k127_7276180_1 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000007578 249.0
SHD2_k127_7276180_2 PFAM Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000000000000000000000001716 190.0
SHD2_k127_7276180_3 YCII-related domain - - - 0.0000000000000000001405 91.0
SHD2_k127_729208_0 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009896 289.0
SHD2_k127_729208_1 - - - - 0.00000000000000000000000000000000000000000004589 168.0
SHD2_k127_729208_2 - - - - 0.000000000000000000001089 101.0
SHD2_k127_7361070_0 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 358.0
SHD2_k127_7361070_1 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000524 268.0
SHD2_k127_7361070_2 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000001882 258.0
SHD2_k127_7361070_3 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000006021 211.0
SHD2_k127_7361070_4 SMART Excinuclease ABC, C subunit - - - 0.000000000000000000000000000000000000000002786 160.0
SHD2_k127_7361070_5 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000002899 160.0
SHD2_k127_7364419_0 PFAM Glycosyl transferase family 2 - - - 2.208e-301 941.0
SHD2_k127_7368728_0 Helix-turn-helix domain protein K07731 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 361.0
SHD2_k127_7368728_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000143 248.0
SHD2_k127_7368728_2 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000005427 92.0
SHD2_k127_7378795_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.016e-249 777.0
SHD2_k127_7378795_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 7.688e-226 711.0
SHD2_k127_7378795_2 WxcM-like, C-terminal K01790 - 5.1.3.13 0.0000000001455 62.0
SHD2_k127_7393555_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 592.0
SHD2_k127_7393555_1 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 401.0
SHD2_k127_7393555_2 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 351.0
SHD2_k127_7393555_3 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 355.0
SHD2_k127_7393555_4 Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000002632 175.0
SHD2_k127_7393555_5 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000009723 146.0
SHD2_k127_7414984_0 Type II IV secretion system protein K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 528.0
SHD2_k127_7414984_1 PFAM Bacterial type II secretion system protein F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002335 253.0
SHD2_k127_7414984_2 TIGRFAM prepilin-type N-terminal cleavage methylation domain - - - 0.0000000004703 70.0
SHD2_k127_7420280_0 Co Zn Cd efflux system component K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002828 255.0
SHD2_k127_7420280_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000004198 124.0
SHD2_k127_7426477_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 8.105e-218 686.0
SHD2_k127_7426477_1 PFAM Cys Met metabolism K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000000000000254 196.0
SHD2_k127_7426477_2 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000001947 184.0
SHD2_k127_7426477_3 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.000000000000000000000000000000000000000001803 160.0
SHD2_k127_7426477_4 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000000000001559 128.0
SHD2_k127_7437391_0 UV-endonuclease UvdE K13281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 358.0
SHD2_k127_7437391_1 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000158 241.0
SHD2_k127_7437391_2 PFAM HhH-GPD family protein K03575 - - 0.000000000000000000000000000000000000000000000000000009851 202.0
SHD2_k127_7447234_0 COG3119 Arylsulfatase A and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000006534 209.0
SHD2_k127_7449638_0 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000009417 143.0
SHD2_k127_7449638_1 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000002615 65.0
SHD2_k127_7450888_0 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000002214 253.0
SHD2_k127_7450888_1 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000000000000000000000001436 217.0
SHD2_k127_7450888_2 - - - - 0.00000000000000000000000000000000003275 146.0
SHD2_k127_7450888_3 Glutaredoxin - - - 0.00000000000000000000000000000008577 125.0
SHD2_k127_7450888_4 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000002262 103.0
SHD2_k127_7470787_0 PFAM Radical SAM domain protein K02585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000988 488.0
SHD2_k127_7470787_1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 340.0
SHD2_k127_7470787_10 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000001218 172.0
SHD2_k127_7470787_11 DNA ligase D, 3-phosphoesterase domain - - - 0.0000000000000000000000000000000000000000000003439 179.0
SHD2_k127_7470787_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000001229 147.0
SHD2_k127_7470787_13 TGS domain protein K06942 - - 0.0000000000000000000000000000000005787 133.0
SHD2_k127_7470787_14 Zinc-ribbon containing domain - - - 0.000000000000000000000000000000002014 130.0
SHD2_k127_7470787_15 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.0000000000000005579 79.0
SHD2_k127_7470787_16 PFAM Protein kinase domain - - - 0.00000006111 63.0
SHD2_k127_7470787_2 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 301.0
SHD2_k127_7470787_3 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002789 261.0
SHD2_k127_7470787_4 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007197 249.0
SHD2_k127_7470787_5 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000544 211.0
SHD2_k127_7470787_6 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000004962 206.0
SHD2_k127_7470787_7 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.000000000000000000000000000000000000000000000000000006958 192.0
SHD2_k127_7470787_8 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000000000000000000000000000000001958 191.0
SHD2_k127_7470787_9 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000001969 190.0
SHD2_k127_7479305_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 559.0
SHD2_k127_7479305_1 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.00000000000000000000000000000000000000000000000000000000000000000000000000003309 262.0
SHD2_k127_7479305_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000003519 215.0
SHD2_k127_7479305_3 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000001345 160.0
SHD2_k127_7502269_0 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 554.0
SHD2_k127_7502269_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000002141 156.0
SHD2_k127_7502269_2 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.000000000000000000000000000000000002252 155.0
SHD2_k127_7502269_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000002922 139.0
SHD2_k127_7502269_4 KaiB K08481 - - 0.00000000000000000000000000000008488 124.0
SHD2_k127_7502269_5 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000006154 56.0
SHD2_k127_7511019_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006394 543.0
SHD2_k127_7511019_1 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000006961 134.0
SHD2_k127_7511019_2 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.000000000000000000002799 109.0
SHD2_k127_7536008_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 451.0
SHD2_k127_7536008_1 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 358.0
SHD2_k127_7536008_2 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 310.0
SHD2_k127_7536008_3 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 293.0
SHD2_k127_7536008_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000002675 88.0
SHD2_k127_7536008_5 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000000007844 74.0
SHD2_k127_7569830_0 two-component system sensor protein - - - 0.000000000000000000000000000000000000000000000000001835 195.0
SHD2_k127_7609617_0 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000000000000000000000000004252 178.0
SHD2_k127_7609617_1 PFAM TfuA domain protein, core - - - 0.00000000000000000000000000000000000000958 148.0
SHD2_k127_7609617_2 Metallo-beta-lactamase superfamily K02238 - - 0.0000001494 57.0
SHD2_k127_7652670_0 in RNase L inhibitor, RLI K06174 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 533.0
SHD2_k127_7652670_1 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002055 252.0
SHD2_k127_7652670_2 RNase L inhibitor, RLI - - - 0.000000000000000000000000000000000505 134.0
SHD2_k127_7686299_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 5.832e-224 707.0
SHD2_k127_7686299_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.0000000000000000000000000000000000000000000000000000977 195.0
SHD2_k127_7686299_2 PFAM PKD domain containing protein - - - 0.000000000009968 79.0
SHD2_k127_7688823_0 Rhodanese-like domain K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 451.0
SHD2_k127_7688823_1 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 339.0
SHD2_k127_7688823_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001124 261.0
SHD2_k127_7688823_3 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000004003 223.0
SHD2_k127_7688823_4 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000002544 182.0
SHD2_k127_7688823_5 extracellular matrix structural constituent - - - 0.00000000000000000002656 93.0
SHD2_k127_7708079_0 Voltage gated chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006161 386.0
SHD2_k127_7708079_1 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000002742 183.0
SHD2_k127_7708079_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000003918 177.0
SHD2_k127_7708079_3 LURP-one-related - - - 0.000000000000000000000000000000000002207 145.0
SHD2_k127_7708079_4 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000307 117.0
SHD2_k127_7708079_5 LURP-one-related - - - 0.00000000000000000000001159 112.0
SHD2_k127_7708079_6 Glutaredoxin - - - 0.0000000000000004028 84.0
SHD2_k127_7802108_0 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 617.0
SHD2_k127_781098_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 5e-324 1008.0
SHD2_k127_781098_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 407.0
SHD2_k127_781098_2 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000003548 217.0
SHD2_k127_781098_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000002292 204.0
SHD2_k127_788248_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 513.0
SHD2_k127_788248_1 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000000004977 210.0
SHD2_k127_788248_2 Transcriptional regulator K07108 - - 0.0000000000000000000000000000001678 130.0
SHD2_k127_788248_3 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000000000000003846 121.0
SHD2_k127_788248_4 transcriptional regulators K03724 - - 0.000000000000000000000000003183 112.0
SHD2_k127_788248_5 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000000000005111 110.0
SHD2_k127_788248_6 nucleic acid binding OB-fold tRNA helicase-type - - - 0.00001716 49.0
SHD2_k127_7899437_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1841.0
SHD2_k127_7900730_0 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 2.555e-218 684.0
SHD2_k127_7900730_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.115e-197 620.0
SHD2_k127_7900730_2 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000506 352.0
SHD2_k127_7900730_3 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002989 280.0
SHD2_k127_7900730_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.000000000000000000000000000000000005651 138.0
SHD2_k127_7900730_5 Roadblock LC7 family protein K06945,K07131 - - 0.00000000000000000000000000000000002149 138.0
SHD2_k127_792327_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 8.478e-200 625.0
SHD2_k127_792327_1 PFAM NAD dependent epimerase dehydratase family K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 405.0
SHD2_k127_792327_2 PFAM Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006138 258.0
SHD2_k127_792327_3 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000002395 199.0
SHD2_k127_792327_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000001013 193.0
SHD2_k127_792327_5 PFAM NAD-dependent epimerase dehydratase K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000001155 177.0
SHD2_k127_792327_6 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000002918 147.0
SHD2_k127_7928844_0 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 1.63e-200 637.0
SHD2_k127_7928844_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000003163 157.0
SHD2_k127_7934079_0 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 430.0
SHD2_k127_7934079_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000003297 231.0
SHD2_k127_7934079_2 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000004909 200.0
SHD2_k127_7934079_3 amino acid K16263 - - 0.000000000000000000000000000000000000000000000000001246 198.0
SHD2_k127_7934079_4 Domain of unknown function (DUF371) K09738 - - 0.00000000000000000000000000000000000000000002395 164.0
SHD2_k127_7934079_5 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000003083 134.0
SHD2_k127_7934079_6 Binds to the 23S rRNA K02896 - - 0.000000000000000000000000000009006 119.0
SHD2_k127_7934079_7 Acyl-CoA thioester hydrolase/BAAT N-terminal region K06889 - - 0.00000000000000000000000001103 120.0
SHD2_k127_7934079_8 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000004169 111.0
SHD2_k127_7934079_9 exodeoxyribonuclease VII activity K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.00009747 47.0
SHD2_k127_7945298_0 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 512.0
SHD2_k127_7945298_1 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007537 361.0
SHD2_k127_7945298_2 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 337.0
SHD2_k127_7945298_3 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000003008 223.0
SHD2_k127_7945298_4 NfeD-like C-terminal, partner-binding - - - 0.000000002994 59.0
SHD2_k127_8007379_0 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 355.0
SHD2_k127_8007379_1 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000005451 74.0
SHD2_k127_8007379_2 COG1361 S-layer domain - - - 0.0000000000001695 73.0
SHD2_k127_8009058_0 permease K03299 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 372.0
SHD2_k127_8009058_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000004464 153.0
SHD2_k127_8009058_2 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000001285 131.0
SHD2_k127_8009058_3 PAS domain K03406 - - 0.0000000000000000002382 89.0
SHD2_k127_8012046_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1138.0
SHD2_k127_8012046_1 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 438.0
SHD2_k127_8012046_2 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 404.0
SHD2_k127_8012046_3 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000008728 192.0
SHD2_k127_8012046_4 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000003432 173.0
SHD2_k127_8053447_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 417.0
SHD2_k127_8053447_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 347.0
SHD2_k127_8053447_2 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000000002427 157.0
SHD2_k127_8053447_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000004335 89.0
SHD2_k127_8053447_4 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000037 76.0
SHD2_k127_8053447_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000657 67.0
SHD2_k127_8071126_0 L-lactate permease K03303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 542.0
SHD2_k127_8071126_1 Protein of unknown function (DUF1232) - - - 0.000000000000002254 85.0
SHD2_k127_8092276_0 Hydrolase CocE NonD family K06978 - - 6.428e-255 797.0
SHD2_k127_8092276_1 Hydrolase CocE NonD family K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001314 275.0
SHD2_k127_8092490_0 TIGRFAM ribosomal protein L30P K02907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003948 261.0
SHD2_k127_8092490_1 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000000000000000000000000000000000000000000000000000000002016 218.0
SHD2_k127_8092490_2 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000005157 179.0
SHD2_k127_8092490_3 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000001434 114.0
SHD2_k127_8095365_0 protein with protein kinase and helix-hairpin-helix DNA-binding domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000055 364.0
SHD2_k127_8095365_1 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000000000000000000000004952 222.0
SHD2_k127_8127714_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1206.0
SHD2_k127_8127714_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 547.0
SHD2_k127_8127714_2 - - - - 0.00000000000000000000000000000000000000000000000000000006969 215.0
SHD2_k127_8127714_3 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000001256 198.0
SHD2_k127_8161446_0 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 467.0
SHD2_k127_8161446_1 phosphatidylinositol N-acetylglucosaminyltransferase activity K03857 - 2.4.1.198 0.00000000000000000000000000000000000000001568 165.0
SHD2_k127_816859_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 620.0
SHD2_k127_816859_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 382.0
SHD2_k127_816859_2 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000006955 140.0
SHD2_k127_816859_3 PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily K06996 - - 0.000002443 50.0
SHD2_k127_8171093_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 3.942e-255 797.0
SHD2_k127_8171093_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 2.633e-202 641.0
SHD2_k127_8171093_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.000000000000000000000000000002729 139.0
SHD2_k127_8171093_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000005942 103.0
SHD2_k127_8181574_0 PFAM AMP-dependent synthetase and ligase K00666 - - 4.39e-301 938.0
SHD2_k127_8181574_1 deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 344.0
SHD2_k127_8181574_2 Protein of unknown function (DUF421) - - - 0.0000000000000003239 83.0
SHD2_k127_8181574_3 Protein of unknown function (DUF421) - - - 0.0009536 48.0
SHD2_k127_8188911_0 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000000000000000000000001673 246.0
SHD2_k127_8188911_1 - - - - 0.0000000000000000000000000000000000000000000000000001472 202.0
SHD2_k127_8188911_2 PFAM HEPN domain - - - 0.0000000000000000000000000000000000005218 146.0
SHD2_k127_8188911_3 PFAM PKD domain containing protein - - - 0.00000000000000000001393 108.0
SHD2_k127_8220858_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006787 392.0
SHD2_k127_8220858_1 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.00000415 51.0
SHD2_k127_8221626_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 514.0
SHD2_k127_8272195_0 cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 452.0
SHD2_k127_8272195_1 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 302.0
SHD2_k127_8272195_2 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000000000000009035 140.0
SHD2_k127_8272195_3 - - - - 0.0000000000007321 74.0
SHD2_k127_8272195_4 - - - - 0.0000007673 59.0
SHD2_k127_8294727_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 1.735e-237 767.0
SHD2_k127_8294727_1 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 387.0
SHD2_k127_8294727_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 374.0
SHD2_k127_8294727_3 TIGRFAM phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006504 273.0
SHD2_k127_8294727_4 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000009674 234.0
SHD2_k127_8294727_5 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000004204 226.0
SHD2_k127_8294727_6 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000001269 137.0
SHD2_k127_8340895_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007795 508.0
SHD2_k127_8340895_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 371.0
SHD2_k127_8340895_2 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 341.0
SHD2_k127_8340895_3 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000001693 271.0
SHD2_k127_8340895_4 Domain of unknown function (DUF1743) - - - 0.00000000000000000000000002072 111.0
SHD2_k127_8354930_0 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 346.0
SHD2_k127_8354930_1 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000000000000000000003476 185.0
SHD2_k127_8354930_2 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.000000000000000007644 83.0
SHD2_k127_8354930_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000906 76.0
SHD2_k127_8356057_0 DEAD DEAH box helicase K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 304.0
SHD2_k127_8388958_0 Flavodoxin-like fold K00355 - 1.6.5.2 0.0000000000000000000000000000000000000000001021 168.0
SHD2_k127_897665_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 438.0
SHD2_k127_897665_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 315.0
SHD2_k127_90200_0 Lon protease (S16) C-terminal proteolytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 299.0
SHD2_k127_90200_1 Matrixin - - - 0.00000000000000000000000000000000004449 153.0
SHD2_k127_90200_2 - - - - 0.0000000000000000000000000000002286 135.0
SHD2_k127_90200_3 - - - - 0.000000001171 63.0
SHD2_k127_911820_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 568.0
SHD2_k127_911820_1 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 389.0
SHD2_k127_911820_2 PFAM PKD domain containing protein - - - 0.00000000000882 72.0
SHD2_k127_911820_3 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000001396 73.0
SHD2_k127_911820_4 PFAM Methyltransferase type - - - 0.000003098 58.0
SHD2_k127_926463_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 1.721e-214 672.0
SHD2_k127_926463_1 PFAM phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 480.0
SHD2_k127_926463_2 Helix-turn-helix domain protein K03627 - - 0.000000000000000000000000000000000000000000000000101 182.0
SHD2_k127_926463_3 beta-lactamase domain protein - - - 0.00000000000000000000000000000000007546 135.0
SHD2_k127_926463_4 - - - - 0.00002656 46.0
SHD2_k127_931394_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1227.0
SHD2_k127_931394_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 535.0
SHD2_k127_947275_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1506.0
SHD2_k127_947275_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 1.817e-239 753.0
SHD2_k127_947275_2 SMART Elongator protein 3 MiaB NifB - - - 1.314e-222 707.0
SHD2_k127_947275_3 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 516.0
SHD2_k127_947275_4 tRNAHis guanylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003456 278.0
SHD2_k127_947275_5 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006224 269.0
SHD2_k127_947275_6 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000006088 173.0
SHD2_k127_947275_7 PFAM PRC-barrel domain - - - 0.000000000000000000000000000000000000001152 151.0
SHD2_k127_947275_8 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000003292 124.0
SHD2_k127_947275_9 phosphoesterase RecJ domain protein - - - 0.000000000000008676 75.0
SHD2_k127_963367_0 AAA domain - - - 3.728e-320 1025.0
SHD2_k127_963367_1 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000001715 169.0
SHD2_k127_969124_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K02474 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 499.0
SHD2_k127_969124_1 PFAM NAD dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008427 279.0
SHD2_k127_969124_2 COG1202 Superfamily II helicase, archaea-specific - - - 0.00000000000000000000000000000000000000000000000000000004881 204.0
SHD2_k127_969124_3 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.0000000000000000000000000000000000008594 141.0