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Overview

ID MAG03381
Name SHD2_bin.4
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Gemmatimonadales
Family GWC2-71-9
Genus JAGGAG01
Species
Assembly information
Completeness (%) 71.88
Contamination (%) 1.75
GC content (%) 71.0
N50 (bp) 9,116
Genome size (bp) 2,301,759

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2078

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1022083_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 4.507e-251 787.0
SHD2_k127_1022083_1 C-terminus of AA_permease K03294 - - 6.987e-213 673.0
SHD2_k127_1022083_2 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 511.0
SHD2_k127_1022083_3 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 499.0
SHD2_k127_1022083_4 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 400.0
SHD2_k127_1022083_5 DHH family K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000258 253.0
SHD2_k127_1022083_6 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000007104 207.0
SHD2_k127_1022083_7 - - - - 0.00000000000000006226 87.0
SHD2_k127_1055361_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003229 626.0
SHD2_k127_1055361_1 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005262 272.0
SHD2_k127_1055361_2 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000004255 158.0
SHD2_k127_1055361_3 LysM domain K13735 GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605 - 0.0000000000000000000000000000000000000003183 158.0
SHD2_k127_1055361_4 Chromate resistance exported protein - - - 0.00000000000000000000000504 108.0
SHD2_k127_1055361_5 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000005317 70.0
SHD2_k127_1059199_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 305.0
SHD2_k127_1059199_1 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000003311 239.0
SHD2_k127_1059199_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000004909 137.0
SHD2_k127_1067315_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 2.448e-214 673.0
SHD2_k127_1067315_1 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 504.0
SHD2_k127_1067315_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 320.0
SHD2_k127_1067315_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000008353 150.0
SHD2_k127_1072801_0 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 632.0
SHD2_k127_1072801_1 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 405.0
SHD2_k127_1072801_2 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 363.0
SHD2_k127_1072801_3 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000003322 185.0
SHD2_k127_1072801_4 protein kinase activity - - - 0.000000000000000000000000002437 130.0
SHD2_k127_1080978_0 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 339.0
SHD2_k127_1080978_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 304.0
SHD2_k127_1080978_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003771 274.0
SHD2_k127_1080978_3 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000002147 191.0
SHD2_k127_1080978_4 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) - - - 0.0000000000000000000000000003705 130.0
SHD2_k127_1080978_5 Isocitrate lyase K01637 - 4.1.3.1 0.0000000000000000000000005695 115.0
SHD2_k127_1080978_6 3-demethylubiquinone-9 3-O-methyltransferase activity K15257 - - 0.0000000000000000000001198 115.0
SHD2_k127_1080978_7 Belongs to the malate synthase family K01637,K01638 GO:0003674,GO:0003824,GO:0004451,GO:0004474,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008340,GO:0009987,GO:0010259,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0046912,GO:0048856,GO:0071704 2.3.3.9,4.1.3.1 0.00004633 46.0
SHD2_k127_108545_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 372.0
SHD2_k127_108545_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 311.0
SHD2_k127_108545_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000004131 231.0
SHD2_k127_108545_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000001342 203.0
SHD2_k127_108545_4 dioxygenase of extradiol dioxygenase family K06991 - - 0.00000000000000000000000000000000000000000000000007578 186.0
SHD2_k127_108545_5 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000001938 171.0
SHD2_k127_112493_0 Elongation factor G, domain IV K02355 - - 4.825e-239 757.0
SHD2_k127_112493_1 Group II decarboxylase family protein K01580 - 4.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 404.0
SHD2_k127_112493_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059,K07124 - 1.1.1.100 0.00000000000000000000000000000000000000008817 160.0
SHD2_k127_112493_3 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000009663 157.0
SHD2_k127_112493_4 - - - - 0.00000000000000000000000002884 119.0
SHD2_k127_112493_5 - - - - 0.0000000000000000000008164 109.0
SHD2_k127_112493_6 - - - - 0.000000000000000003905 91.0
SHD2_k127_112493_7 Lysin motif - - - 0.0000000000007236 71.0
SHD2_k127_1183371_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 1.534e-238 749.0
SHD2_k127_1183371_1 PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein K01740,K10764 - 2.5.1.49 4.472e-206 648.0
SHD2_k127_1183371_10 - - - - 0.0000000000000000006966 91.0
SHD2_k127_1183371_11 Cupin 2, conserved barrel domain protein - - - 0.000000000000009057 82.0
SHD2_k127_1183371_12 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000001163 69.0
SHD2_k127_1183371_2 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001805 306.0
SHD2_k127_1183371_3 membrane protein, hemolysin III homolog K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001089 251.0
SHD2_k127_1183371_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008937 265.0
SHD2_k127_1183371_5 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000929 222.0
SHD2_k127_1183371_6 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000006854 201.0
SHD2_k127_1183371_7 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000004629 172.0
SHD2_k127_1183371_8 domain protein K06929 - - 0.000000000000000000000000000000000000001256 161.0
SHD2_k127_1183371_9 hydroperoxide reductase activity - - - 0.0000000000000000000000000000000000002758 146.0
SHD2_k127_1203720_0 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 516.0
SHD2_k127_1203720_1 Phosphoribosyl transferase domain K07101 - - 0.000000000000000000000000000000000000000000000001568 181.0
SHD2_k127_1203720_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000111 178.0
SHD2_k127_1203720_3 - - - - 0.0000000000000007774 85.0
SHD2_k127_1203720_4 Bacterial Ig-like domain 2 - - - 0.00007234 55.0
SHD2_k127_1203720_5 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0003777 48.0
SHD2_k127_122472_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 505.0
SHD2_k127_122472_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 454.0
SHD2_k127_122472_2 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 299.0
SHD2_k127_122472_3 hydrolase, TatD K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000001314 222.0
SHD2_k127_122472_4 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000002214 214.0
SHD2_k127_122472_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000001245 97.0
SHD2_k127_122472_6 protein conserved in bacteria K09764 - - 0.0000000000001075 74.0
SHD2_k127_1252744_0 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA K01638 - 2.3.3.9 0.0 1064.0
SHD2_k127_1252744_1 Multicopper oxidase K22348 - 1.16.3.3 5.623e-195 627.0
SHD2_k127_1252744_10 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000003687 144.0
SHD2_k127_1252744_11 - - - - 0.00000000000001466 76.0
SHD2_k127_1252744_12 Cupin 2, conserved barrel domain protein - - - 0.000003356 49.0
SHD2_k127_1252744_2 arylsulfatase activity K01132 - 3.1.6.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 523.0
SHD2_k127_1252744_3 Alpha/beta hydrolase family K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 447.0
SHD2_k127_1252744_4 amine dehydrogenase activity K17285 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001905 316.0
SHD2_k127_1252744_5 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005284 271.0
SHD2_k127_1252744_6 Amidinotransferase K01482 - 3.5.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000151 259.0
SHD2_k127_1252744_7 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001439 231.0
SHD2_k127_1252744_8 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000004395 214.0
SHD2_k127_1252744_9 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000000000000000247 147.0
SHD2_k127_1262505_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 5.724e-207 664.0
SHD2_k127_1262505_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 1.467e-199 642.0
SHD2_k127_1262505_10 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 450.0
SHD2_k127_1262505_11 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 402.0
SHD2_k127_1262505_12 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 369.0
SHD2_k127_1262505_13 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 327.0
SHD2_k127_1262505_14 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003805 331.0
SHD2_k127_1262505_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 336.0
SHD2_k127_1262505_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 321.0
SHD2_k127_1262505_17 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 311.0
SHD2_k127_1262505_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 306.0
SHD2_k127_1262505_19 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 309.0
SHD2_k127_1262505_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 7.075e-199 628.0
SHD2_k127_1262505_20 Acyl transferase domain K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000192 299.0
SHD2_k127_1262505_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001976 272.0
SHD2_k127_1262505_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000002269 257.0
SHD2_k127_1262505_23 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000001271 244.0
SHD2_k127_1262505_24 NDK K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000001337 214.0
SHD2_k127_1262505_25 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000003987 182.0
SHD2_k127_1262505_26 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000004911 125.0
SHD2_k127_1262505_27 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000001187 121.0
SHD2_k127_1262505_28 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000004437 115.0
SHD2_k127_1262505_29 Uncharacterised protein family (UPF0182) K09118 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000001294 128.0
SHD2_k127_1262505_3 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007764 578.0
SHD2_k127_1262505_30 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000002369 114.0
SHD2_k127_1262505_31 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000001907 80.0
SHD2_k127_1262505_32 Ribosomal L32p protein family K02911 - - 0.0000000000002651 72.0
SHD2_k127_1262505_33 SNARE associated Golgi protein - - - 0.0000000000005055 83.0
SHD2_k127_1262505_34 PFAM Outer membrane efflux protein K15725 - - 0.0000000005748 71.0
SHD2_k127_1262505_4 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 535.0
SHD2_k127_1262505_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 505.0
SHD2_k127_1262505_6 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009895 501.0
SHD2_k127_1262505_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 488.0
SHD2_k127_1262505_8 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009451 481.0
SHD2_k127_1262505_9 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 490.0
SHD2_k127_1313750_0 protein secretion by the type I secretion system K11085 - - 4.131e-238 752.0
SHD2_k127_1313750_1 PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 535.0
SHD2_k127_1313750_10 - - - - 0.0001868 54.0
SHD2_k127_1313750_2 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 428.0
SHD2_k127_1313750_3 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 422.0
SHD2_k127_1313750_4 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 419.0
SHD2_k127_1313750_5 MatE K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007669 389.0
SHD2_k127_1313750_6 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000002034 156.0
SHD2_k127_1313750_7 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000000000004832 151.0
SHD2_k127_1313750_8 - - - - 0.00000000008721 70.0
SHD2_k127_1313750_9 - - - - 0.000000001591 65.0
SHD2_k127_1323647_0 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004501 280.0
SHD2_k127_1323647_1 Protein involved in cellulose biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002726 283.0
SHD2_k127_1323647_2 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.00000000000000000000000000000001892 141.0
SHD2_k127_1343400_0 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000105 218.0
SHD2_k127_1343400_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000003844 173.0
SHD2_k127_1343400_2 helix_turn_helix, mercury resistance K22491 - - 0.0000000000000004251 85.0
SHD2_k127_1343400_3 YceI-like domain - - - 0.00000000000004967 81.0
SHD2_k127_1343400_5 - - - - 0.000001491 59.0
SHD2_k127_135970_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004433 471.0
SHD2_k127_135970_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 485.0
SHD2_k127_135970_10 NUDIX domain K08310 - 3.6.1.67 0.00000000000000000000000000000000000829 151.0
SHD2_k127_135970_11 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000008895 147.0
SHD2_k127_135970_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 299.0
SHD2_k127_135970_3 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000003347 245.0
SHD2_k127_135970_4 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000001929 244.0
SHD2_k127_135970_5 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817,K04720 - 2.6.1.9,4.1.1.81 0.000000000000000000000000000000000000000000000000000000000004711 238.0
SHD2_k127_135970_6 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000000000000000001708 226.0
SHD2_k127_135970_7 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000000007509 192.0
SHD2_k127_135970_8 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000006232 198.0
SHD2_k127_135970_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000163 167.0
SHD2_k127_1362190_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 367.0
SHD2_k127_1362190_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 312.0
SHD2_k127_1362190_2 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002076 263.0
SHD2_k127_1362190_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000001161 220.0
SHD2_k127_1362190_4 Glutathione peroxidase - - - 0.0000000000000000000000000000000000000000007697 167.0
SHD2_k127_1362190_5 DinB family - - - 0.000000000000000000000000000000000002493 143.0
SHD2_k127_1362190_6 - - - - 0.0000000000000000001237 91.0
SHD2_k127_1362190_9 PFAM PASTA domain - - - 0.00001111 55.0
SHD2_k127_1367028_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 432.0
SHD2_k127_1367028_1 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000005277 210.0
SHD2_k127_1367028_2 - - - - 0.0000000000000005877 80.0
SHD2_k127_1367028_3 lyase activity - - - 0.00000000000001924 87.0
SHD2_k127_1367028_4 Carboxypeptidase regulatory-like domain - - - 0.000000004038 64.0
SHD2_k127_1367028_5 - - - - 0.00001132 56.0
SHD2_k127_1370639_0 Putative RNA methylase family UPF0020 K07444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 342.0
SHD2_k127_1370639_1 antibiotic catabolic process K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003561 334.0
SHD2_k127_1370639_3 - - - - 0.0000000000000000000000000000000000000000000001176 188.0
SHD2_k127_1370639_4 Phosphodiester glycosidase - - - 0.00000000000000000000000000000000000000000001882 183.0
SHD2_k127_1377161_0 AcrB/AcrD/AcrF family - - - 1.648e-317 1002.0
SHD2_k127_1377161_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.582e-257 803.0
SHD2_k127_1377161_10 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.000000000000000000000000000000000000000000000000001983 188.0
SHD2_k127_1377161_11 Lipopolysaccharide-assembly, LptC-related - - - 0.000000000000000000000001994 118.0
SHD2_k127_1377161_12 Outer membrane efflux protein - - - 0.00000000000000000004181 100.0
SHD2_k127_1377161_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000001664 73.0
SHD2_k127_1377161_14 - - - - 0.0000000002174 72.0
SHD2_k127_1377161_15 DinB superfamily - - - 0.0008036 52.0
SHD2_k127_1377161_2 SIS domain K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 353.0
SHD2_k127_1377161_3 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000061 321.0
SHD2_k127_1377161_4 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 289.0
SHD2_k127_1377161_5 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003193 258.0
SHD2_k127_1377161_6 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000001016 246.0
SHD2_k127_1377161_7 Peptidase C26 K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000746 252.0
SHD2_k127_1377161_8 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000007938 239.0
SHD2_k127_1377161_9 Putative ABC exporter - - - 0.000000000000000000000000000000000000000000000000001496 205.0
SHD2_k127_1388369_0 Bacterial regulatory protein, Fis family - - - 2.554e-206 653.0
SHD2_k127_1388369_1 Beta-eliminating lyase K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 565.0
SHD2_k127_1388369_2 Chain length determinant protein K16554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006935 561.0
SHD2_k127_1388369_3 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007898 437.0
SHD2_k127_1388369_4 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008766 374.0
SHD2_k127_1388369_5 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003025 265.0
SHD2_k127_1388369_6 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000003385 179.0
SHD2_k127_1388369_7 short-chain dehydrogenase reductase - - - 0.000000000000000000000000000000000000000003076 159.0
SHD2_k127_1388369_9 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0004293 46.0
SHD2_k127_1448471_0 Xaa-Pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 591.0
SHD2_k127_1448471_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 503.0
SHD2_k127_1448471_2 Nitronate monooxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 326.0
SHD2_k127_1448471_3 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 285.0
SHD2_k127_1448471_4 Glyoxalase-like domain K07032 - - 0.000000000000000000000000000000000000000000000000006747 185.0
SHD2_k127_1448471_5 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000001989 154.0
SHD2_k127_1448471_6 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000004285 146.0
SHD2_k127_1454244_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 471.0
SHD2_k127_1454244_1 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 464.0
SHD2_k127_1454244_10 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000008576 198.0
SHD2_k127_1454244_11 Hydrolase - - - 0.00000000000000000000000000000000007213 149.0
SHD2_k127_1454244_12 Peptidase dimerisation domain K01438 - 3.5.1.16 0.000006897 51.0
SHD2_k127_1454244_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 422.0
SHD2_k127_1454244_3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00857,K01920,K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 340.0
SHD2_k127_1454244_4 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 325.0
SHD2_k127_1454244_5 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 293.0
SHD2_k127_1454244_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002504 300.0
SHD2_k127_1454244_7 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000002721 265.0
SHD2_k127_1454244_8 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145,K05829 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000004141 226.0
SHD2_k127_1454244_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000002207 209.0
SHD2_k127_146015_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 5.567e-311 972.0
SHD2_k127_146015_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 8.047e-253 799.0
SHD2_k127_146015_2 transporter MgtE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 517.0
SHD2_k127_146015_3 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 482.0
SHD2_k127_146015_4 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 344.0
SHD2_k127_146015_5 - - - - 0.0000000000000000000005478 112.0
SHD2_k127_1484981_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 390.0
SHD2_k127_1484981_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000006494 195.0
SHD2_k127_1484981_2 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000001106 180.0
SHD2_k127_1484981_3 SnoaL-like domain - - - 0.00000000000000005653 87.0
SHD2_k127_1507755_0 PglZ domain - - - 4.638e-196 623.0
SHD2_k127_1507755_1 ABC transporter transmembrane region K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 402.0
SHD2_k127_1507755_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000412 181.0
SHD2_k127_1507755_3 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000005423 196.0
SHD2_k127_1507755_4 Glycosyltransferase Family 4 K13668 - 2.4.1.346 0.000000000000000000000000000000007188 140.0
SHD2_k127_1507755_5 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.0000000000000000000001056 111.0
SHD2_k127_1507755_6 Glycosyltransferase Family 4 - - - 0.000000000000000004207 97.0
SHD2_k127_1507755_7 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.0000001084 64.0
SHD2_k127_1520304_0 Zn_pept - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 449.0
SHD2_k127_1520304_1 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000001515 221.0
SHD2_k127_1520304_2 peroxiredoxin activity K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.000000000000000000000000000000000000000000000000000000003183 210.0
SHD2_k127_1520304_3 Major facilitator superfamily K08151 - - 0.0000000006467 66.0
SHD2_k127_152739_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1427.0
SHD2_k127_152739_1 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007908 511.0
SHD2_k127_152739_2 Sulfatase K01130 - 3.1.6.1 0.0000000000000000000000000000000000000005848 151.0
SHD2_k127_152739_3 Tetratricopeptide repeat - - - 0.0000000007452 70.0
SHD2_k127_152739_4 C-terminal domain of histone - - - 0.00001372 57.0
SHD2_k127_1536094_0 AIR synthase related protein, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008037 250.0
SHD2_k127_1536094_1 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000000000000000000000000000000000001841 216.0
SHD2_k127_1536094_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000001033 126.0
SHD2_k127_1536094_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000243 121.0
SHD2_k127_1536094_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000003093 123.0
SHD2_k127_1536094_5 Domain of unknown function (DUF3943) - - - 0.000000000001771 79.0
SHD2_k127_1536094_6 Domain of unknown function (DUF4824) - - - 0.00000000808 68.0
SHD2_k127_1546214_0 Amidohydrolase family K00200 - 1.2.7.12 2.259e-268 857.0
SHD2_k127_1546214_1 Formylmethanofuran dehydrogenase subunit A K00200 GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281 1.2.7.12 1.039e-206 658.0
SHD2_k127_1546214_10 Methylene-tetrahydromethanopterin dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001309 276.0
SHD2_k127_1546214_11 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000001724 272.0
SHD2_k127_1546214_12 formylmethanofuran dehydrogenase activity K00202 GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000003948 261.0
SHD2_k127_1546214_13 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001696 262.0
SHD2_k127_1546214_14 TIGRFAM formylmethanofuran dehydrogenase subunit C K00202 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000004542 254.0
SHD2_k127_1546214_15 ATP:dephospho-CoA triphosphoribosyl transferase K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000000000000004915 244.0
SHD2_k127_1546214_16 PFAM Formaldehyde-activating enzyme (Fae) K10713 - 4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000004903 226.0
SHD2_k127_1546214_17 CO2 hydration protein (ChpXY) - - - 0.0000000000000000000000000000000000000000000000000000000000003996 233.0
SHD2_k127_1546214_18 ATP-grasp domain K01499,K06913 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000001843 228.0
SHD2_k127_1546214_19 outer membrane protein W K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000036 157.0
SHD2_k127_1546214_2 Atp-dependent helicase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 564.0
SHD2_k127_1546214_20 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000002032 152.0
SHD2_k127_1546214_21 OmpW family K07275 - - 0.000000000000000000000000000000004418 145.0
SHD2_k127_1546214_22 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000008941 130.0
SHD2_k127_1546214_23 PFAM molydopterin dinucleotide-binding region K00203,K00336 - 1.2.7.12,1.6.5.3 0.00000000000037 76.0
SHD2_k127_1546214_24 EthD domain - - - 0.0000000003946 73.0
SHD2_k127_1546214_25 EthD domain - - - 0.00000007745 65.0
SHD2_k127_1546214_3 Molybdopterin oxidoreductase K00201 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 450.0
SHD2_k127_1546214_4 Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) K00672 - 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 442.0
SHD2_k127_1546214_5 TIGRFAM formylmethanofuran dehydrogenase subunit B K00201 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 410.0
SHD2_k127_1546214_6 Formylmethanofuran-tetrahydromethanopterin formyltransferase K00672 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0071704 2.3.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 349.0
SHD2_k127_1546214_7 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0044424,GO:0044464,GO:0071704 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 320.0
SHD2_k127_1546214_8 C1 transfer pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 311.0
SHD2_k127_1546214_9 Formaldehyde-activating enzyme (Fae) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 289.0
SHD2_k127_155787_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1064.0
SHD2_k127_155787_1 Nicastrin K01301 - 3.4.17.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 563.0
SHD2_k127_155787_2 4Fe-4S binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 380.0
SHD2_k127_155787_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 294.0
SHD2_k127_155787_4 LVIVD repeat - - - 0.00000000000000000000000000000000000000000001047 184.0
SHD2_k127_155787_5 - K00241 - - 0.0000000000000000000000000000000000000000001298 164.0
SHD2_k127_155787_6 TIGRFAM outer membrane autotransporter barrel - - - 0.00000002231 62.0
SHD2_k127_1560180_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 7.535e-307 947.0
SHD2_k127_1560180_1 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000002686 183.0
SHD2_k127_1560180_2 - - - - 0.000000000000000000000000000000000000000001205 166.0
SHD2_k127_1560180_3 SCP-2 sterol transfer family - - - 0.000000000000000000000000000001764 126.0
SHD2_k127_1560180_4 Putative adhesin - - - 0.0000000000000000000000004303 115.0
SHD2_k127_1560180_5 PFAM ribonucleotide reductase K00526 - 1.17.4.1 0.00000000000000000001928 94.0
SHD2_k127_1560180_6 AntiSigma factor K03088 - - 0.0005551 51.0
SHD2_k127_1572303_0 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000043 488.0
SHD2_k127_1572303_1 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 446.0
SHD2_k127_1572303_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 440.0
SHD2_k127_1572303_3 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 389.0
SHD2_k127_1572303_4 Methyltransferase small domain K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000002568 180.0
SHD2_k127_1572303_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000001701 154.0
SHD2_k127_1572303_6 PFAM NADP oxidoreductase coenzyme F420-dependent - - - 0.00000000000000000000000000000000000162 149.0
SHD2_k127_1572303_7 Binds the 23S rRNA K02909 - - 0.0000000000000000000001081 101.0
SHD2_k127_1572303_8 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000146 111.0
SHD2_k127_1572303_9 Control of competence regulator ComK, YlbF/YmcA - - - 0.0000000000001016 79.0
SHD2_k127_1572760_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 9.737e-314 991.0
SHD2_k127_1572760_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000004197 210.0
SHD2_k127_1572760_2 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000001984 175.0
SHD2_k127_1583958_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 604.0
SHD2_k127_1583958_1 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 347.0
SHD2_k127_1583958_2 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000219 314.0
SHD2_k127_160654_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1039.0
SHD2_k127_160654_1 Belongs to the glycosyl hydrolase 1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 568.0
SHD2_k127_160654_2 Peptidase S9, prolyl oligopeptidase active site domain protein K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 505.0
SHD2_k127_160654_3 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 420.0
SHD2_k127_160654_4 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005829 383.0
SHD2_k127_160654_5 - - - - 0.00000000000000000000000000000000000000000000000003773 195.0
SHD2_k127_160654_6 Glucose / Sorbosone dehydrogenase - - - 0.000000000000005608 80.0
SHD2_k127_160654_7 Sugar-specific transcriptional regulator TrmB - - - 0.000000003092 66.0
SHD2_k127_160654_8 Rdx family K07401 - - 0.0005303 44.0
SHD2_k127_1644340_0 AcrB/AcrD/AcrF family K07787,K15726 - - 0.0 1456.0
SHD2_k127_1644340_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008331 429.0
SHD2_k127_1644340_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 350.0
SHD2_k127_1666708_0 Collagenase K08303 - - 0.0 1125.0
SHD2_k127_1666708_1 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01668 - 4.1.99.2 1.014e-255 811.0
SHD2_k127_1666708_10 Heat shock 70 kDa protein K04043 - - 0.000002599 50.0
SHD2_k127_1666708_11 Damage-inducible protein DinB - - - 0.000006807 57.0
SHD2_k127_1666708_2 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 568.0
SHD2_k127_1666708_3 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 374.0
SHD2_k127_1666708_4 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 332.0
SHD2_k127_1666708_5 PFAM Uncharacterised BCR, COG1649 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 321.0
SHD2_k127_1666708_6 Inositol monophosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 302.0
SHD2_k127_1666708_7 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002432 263.0
SHD2_k127_1666708_8 creatininase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000005244 232.0
SHD2_k127_1666708_9 Subtilase family - - - 0.0000000000000005323 79.0
SHD2_k127_1704557_0 FtsX-like permease family K02004 - - 2.557e-194 644.0
SHD2_k127_1704557_1 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005556 416.0
SHD2_k127_1704557_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006582 292.0
SHD2_k127_1704557_3 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000142 222.0
SHD2_k127_1704557_4 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000000000000000001932 165.0
SHD2_k127_1704557_5 FCD - - - 0.000001182 55.0
SHD2_k127_1744904_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1079.0
SHD2_k127_1744904_1 ABC transporter transmembrane region K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 616.0
SHD2_k127_1744904_2 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 298.0
SHD2_k127_1744904_3 integral membrane protein K07027 - - 0.000000000000000000003798 106.0
SHD2_k127_1744904_4 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000009919 96.0
SHD2_k127_179801_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 537.0
SHD2_k127_179801_1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 497.0
SHD2_k127_179801_10 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000006824 75.0
SHD2_k127_179801_11 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000002726 56.0
SHD2_k127_179801_12 cAMP biosynthetic process - - - 0.0002298 44.0
SHD2_k127_179801_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 462.0
SHD2_k127_179801_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 434.0
SHD2_k127_179801_4 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002039 258.0
SHD2_k127_179801_5 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.000000000000000000000000000000000000000000001159 168.0
SHD2_k127_179801_6 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000002831 149.0
SHD2_k127_179801_7 Molybdopterin converting factor subunit K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000000009685 141.0
SHD2_k127_179801_8 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 0.00000000000000000000004489 108.0
SHD2_k127_179801_9 Preprotein translocase SecG subunit K03075 - - 0.00000000000000001124 89.0
SHD2_k127_180413_0 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006961 460.0
SHD2_k127_180413_1 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 364.0
SHD2_k127_180413_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 378.0
SHD2_k127_180413_3 cation diffusion facilitator family transporter K16264 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.00000000000000000000000000000000000000000000000000000000000000000000007682 265.0
SHD2_k127_1805858_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 1.761e-212 674.0
SHD2_k127_1805858_1 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 554.0
SHD2_k127_1805858_2 C4-dicarboxylate anaerobic carrier - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 428.0
SHD2_k127_1805858_3 Fatty acid desaturase K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 415.0
SHD2_k127_1805858_4 tungstate binding K15495 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004325 254.0
SHD2_k127_1805858_5 Thioredoxin-like domain K03672 - 1.8.1.8 0.0000000000000000000000000000000000002526 148.0
SHD2_k127_1805858_6 Divalent ion tolerance protein K03926 - - 0.000000000000000000000000001653 114.0
SHD2_k127_1805858_7 GCN5 family acetyltransferase - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 - 0.0003772 49.0
SHD2_k127_1812136_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 605.0
SHD2_k127_1812136_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000458 501.0
SHD2_k127_1812136_10 Domain of unknown function (DUF3473) - - - 0.000000000000000000000003928 104.0
SHD2_k127_1812136_11 - - - - 0.00009168 54.0
SHD2_k127_1812136_12 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000189 53.0
SHD2_k127_1812136_2 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 394.0
SHD2_k127_1812136_3 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 317.0
SHD2_k127_1812136_4 hydroxy-methylglutaryl-CoA lyase K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 309.0
SHD2_k127_1812136_5 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 301.0
SHD2_k127_1812136_6 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000009436 219.0
SHD2_k127_1812136_7 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000003606 216.0
SHD2_k127_1812136_8 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000007373 140.0
SHD2_k127_1812136_9 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000002742 131.0
SHD2_k127_186397_0 ATP-dependent helicase K03579 - 3.6.4.13 1.315e-306 962.0
SHD2_k127_186397_1 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 570.0
SHD2_k127_186397_2 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001115 284.0
SHD2_k127_186397_3 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000007265 246.0
SHD2_k127_186397_4 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000006621 209.0
SHD2_k127_186397_5 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000007153 83.0
SHD2_k127_193_0 membrane organization - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 460.0
SHD2_k127_193_1 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001335 279.0
SHD2_k127_193_2 metallophosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000009183 223.0
SHD2_k127_193_3 Domain of unknown function (DUF4956) - - - 0.0000000000000000000000000000000000000000000000000000005843 206.0
SHD2_k127_1937420_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 322.0
SHD2_k127_1937420_1 PFAM binding-protein-dependent transport systems inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005648 307.0
SHD2_k127_1937420_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001578 278.0
SHD2_k127_1937420_3 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001019 290.0
SHD2_k127_1937420_4 PFAM binding-protein-dependent transport systems inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000003571 256.0
SHD2_k127_1944027_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 542.0
SHD2_k127_1944027_1 - - - - 0.00000000000000000000000000000000000001622 154.0
SHD2_k127_1944027_2 SnoaL-like domain - - - 0.0000000000000000004482 98.0
SHD2_k127_1944027_3 SnoaL-like domain - - - 0.000000000000000001552 93.0
SHD2_k127_1944027_4 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000002474 62.0
SHD2_k127_1944027_5 - - - - 0.00000006042 63.0
SHD2_k127_2003468_0 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 1.824e-206 655.0
SHD2_k127_2003468_1 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 582.0
SHD2_k127_2003468_10 DNA-templated transcription, initiation K02405 - - 0.00000000000001747 74.0
SHD2_k127_2003468_11 Methyltransferase - - - 0.00000000000006154 80.0
SHD2_k127_2003468_2 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008964 413.0
SHD2_k127_2003468_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 413.0
SHD2_k127_2003468_4 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000195 273.0
SHD2_k127_2003468_5 iron ion binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008577 252.0
SHD2_k127_2003468_6 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000001847 226.0
SHD2_k127_2003468_7 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000005708 218.0
SHD2_k127_2003468_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000449 228.0
SHD2_k127_2003468_9 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000001068 192.0
SHD2_k127_2014_0 Domain of unknown function DUF87 - - - 6.091e-279 880.0
SHD2_k127_2014_1 Sugar (and other) transporter K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 376.0
SHD2_k127_2014_2 Peptidase M66 - - - 0.0000000000000000000000000000000000000000000000000000004285 207.0
SHD2_k127_2030164_0 Amidohydrolase family K06015 - 3.5.1.81 7.28e-208 662.0
SHD2_k127_2030164_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 352.0
SHD2_k127_2030164_2 Acetyltransferase (Isoleucine patch superfamily) K18234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 327.0
SHD2_k127_2030164_3 3-oxo-5-alpha-steroid 4-dehydrogenase K12343 - 1.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000006521 250.0
SHD2_k127_2030164_4 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000000003576 163.0
SHD2_k127_2030164_6 - - - - 0.000000009495 68.0
SHD2_k127_20712_0 Glycosyl hydrolase family 1 K00067 - 1.1.1.133 8.606e-232 739.0
SHD2_k127_20712_1 DNA ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 515.0
SHD2_k127_20712_2 COG0438 Glycosyltransferase K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 435.0
SHD2_k127_20712_3 protoporphyrinogen oxidase activity K01854 - 5.4.99.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 388.0
SHD2_k127_20712_4 PFAM short chain dehydrogenase - - - 0.0000000000000000000000000000000000003086 144.0
SHD2_k127_20712_5 Pyridoxamine 5'-phosphate oxidase K00275 - 1.4.3.5 0.0000000000000000000000000000929 123.0
SHD2_k127_20712_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000004144 59.0
SHD2_k127_2082292_0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 509.0
SHD2_k127_2082292_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 510.0
SHD2_k127_2082292_2 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000007548 220.0
SHD2_k127_2082292_3 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000025 94.0
SHD2_k127_2129969_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1284.0
SHD2_k127_2129969_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000001047 251.0
SHD2_k127_2129969_2 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000263 177.0
SHD2_k127_2129969_3 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000001576 66.0
SHD2_k127_2179510_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 620.0
SHD2_k127_2179510_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 445.0
SHD2_k127_2179510_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000003595 218.0
SHD2_k127_2179510_3 SprT-like family - - - 0.00000000000000000000000000000000000000003251 163.0
SHD2_k127_2179510_4 Domain of unknown function (DUF4139) - - - 0.0000000000000000000000000000000000007718 158.0
SHD2_k127_2179510_5 reductase K00059 - 1.1.1.100 0.0000000000000000000008823 96.0
SHD2_k127_2179510_6 Sigma-70, region 4 K03088 - - 0.00000000000000000001773 98.0
SHD2_k127_2183228_0 lysine 2,3-aminomutase activity K01843 - 5.4.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 436.0
SHD2_k127_2183228_1 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 384.0
SHD2_k127_2183228_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 373.0
SHD2_k127_2183228_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 339.0
SHD2_k127_2183228_4 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000002365 193.0
SHD2_k127_2183228_5 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000004738 131.0
SHD2_k127_2183228_6 Acetyltransferase (GNAT) family - - - 0.000000000000000000000005589 117.0
SHD2_k127_2192595_0 chlorophyllide reductase subunit Z K11335 - 1.3.7.14,1.3.7.15 1.374e-259 831.0
SHD2_k127_2192595_1 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein K02587,K04038,K04039,K11334,K11335 - 1.3.7.14,1.3.7.15,1.3.7.7 1.683e-245 768.0
SHD2_k127_2192595_10 Alpha/beta hydrolase family K06049 - - 0.00000000000000000000000000000000000000000000000000000004117 212.0
SHD2_k127_2192595_11 cobalamin synthesis protein - - - 0.000000000000000000000000000000000000000000000000001129 199.0
SHD2_k127_2192595_12 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000005486 130.0
SHD2_k127_2192595_13 Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers K08926 - - 0.000000000002093 68.0
SHD2_k127_2192595_14 Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers K08927 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000001184 66.0
SHD2_k127_2192595_15 Insulinase (Peptidase family M16) K07263 - - 0.0000001547 53.0
SHD2_k127_2192595_2 oxidoreductase activity, acting on iron-sulfur proteins as donors K04037,K11333 - 1.3.7.14,1.3.7.15,1.3.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 575.0
SHD2_k127_2192595_3 PFAM Photosynthetic reaction centre K08928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 498.0
SHD2_k127_2192595_4 The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis K08929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 499.0
SHD2_k127_2192595_5 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 491.0
SHD2_k127_2192595_6 von Willebrand factor (vWF) type A domain K03404 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 472.0
SHD2_k127_2192595_7 Dehydrogenase K11337 - 1.1.1.396 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 431.0
SHD2_k127_2192595_8 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 331.0
SHD2_k127_2192595_9 The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor K13992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 297.0
SHD2_k127_219520_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 518.0
SHD2_k127_219520_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005255 461.0
SHD2_k127_219520_2 Surface antigen K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 416.0
SHD2_k127_219520_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 359.0
SHD2_k127_219520_4 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000002379 158.0
SHD2_k127_219520_5 Response regulator receiver K07669,K07672 - - 0.0000000000000147 80.0
SHD2_k127_2276301_0 Fumarase C C-terminus K01744 - 4.3.1.1 3.817e-197 626.0
SHD2_k127_2276301_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 460.0
SHD2_k127_2276301_10 Cupin 2, conserved barrel domain protein - - - 0.000000000000000005583 89.0
SHD2_k127_2276301_11 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000001629 67.0
SHD2_k127_2276301_12 Peroxiredoxin K03386 - 1.11.1.15 0.00002691 50.0
SHD2_k127_2276301_13 Redoxin K03564 - 1.11.1.15 0.0008038 46.0
SHD2_k127_2276301_2 Glycosyltransferase Family 4 K14335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 396.0
SHD2_k127_2276301_3 KR domain K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000006333 241.0
SHD2_k127_2276301_4 COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - 0.00000000000000000000000000000000000000000000000000000003426 205.0
SHD2_k127_2276301_5 deacetylase K06986 - - 0.00000000000000000000000000000000000000000000000000000008447 219.0
SHD2_k127_2276301_6 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000008174 194.0
SHD2_k127_2276301_7 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.000000000000000000000000000000001352 134.0
SHD2_k127_2276301_8 Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000897 139.0
SHD2_k127_2276301_9 PFAM UBA THIF-type NAD FAD binding protein K21147 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006732,GO:0006777,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0018130,GO:0019344,GO:0019538,GO:0019637,GO:0019720,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043170,GO:0043207,GO:0043436,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0061605,GO:0070566,GO:0071704,GO:0071944,GO:0075136,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.80,2.8.1.11 0.00000000000000000002095 95.0
SHD2_k127_2343962_0 Heavy-metal-associated domain K01533,K17686 - 3.6.3.4,3.6.3.54 5.123e-226 726.0
SHD2_k127_2343962_1 Peptidase S46 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 555.0
SHD2_k127_2343962_2 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 409.0
SHD2_k127_2343962_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003449 247.0
SHD2_k127_2343962_4 Acid phosphatase homologues - - - 0.000000000000000000000000000000000000007365 154.0
SHD2_k127_2343962_5 Complex I intermediate-associated protein 30 (CIA30) - - - 0.0000000000000000000000000002285 127.0
SHD2_k127_2343962_6 Metal-sensitive transcriptional repressor K21600 - - 0.0000000000000000000000000003828 133.0
SHD2_k127_2343962_7 Regulatory protein, FmdB family - - - 0.00000000000004698 74.0
SHD2_k127_2343962_8 mercury ion transmembrane transporter activity K07213 - - 0.000000000006677 70.0
SHD2_k127_2343962_9 Major facilitator superfamily MFS_1 - - - 0.00001005 49.0
SHD2_k127_2348531_0 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000904 502.0
SHD2_k127_2348531_1 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 462.0
SHD2_k127_2348531_2 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 353.0
SHD2_k127_2348531_3 Putative esterase K07017 - - 0.00000000000000000000000000000000000000000000000000000000000000000001829 243.0
SHD2_k127_2348531_4 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000003862 179.0
SHD2_k127_2348531_5 glutamate-cysteine ligase activity K00836 - 2.6.1.76 0.000000000000000000000000000000000696 141.0
SHD2_k127_2348531_6 Resolvase, N terminal domain - - - 0.000006089 53.0
SHD2_k127_2348531_7 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0003438 43.0
SHD2_k127_2352329_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.754e-236 734.0
SHD2_k127_2352329_1 Peptidase dimerisation domain K01439,K13049 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 497.0
SHD2_k127_2352329_2 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 378.0
SHD2_k127_2383332_0 arylsulfatase A K01130 - 3.1.6.1 4.298e-262 825.0
SHD2_k127_2383332_1 Doubled CXXCH motif (Paired_CXXCH_1) - - - 5.875e-203 653.0
SHD2_k127_2383332_2 - K07221 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009202 369.0
SHD2_k127_2383332_3 LysR substrate binding domain - - - 0.0000000000000000000000000000000008825 143.0
SHD2_k127_2383332_4 Predicted membrane protein (DUF2243) - - - 0.0000000000000000000000000002691 119.0
SHD2_k127_2390485_0 - - - - 2.528e-299 953.0
SHD2_k127_2390485_1 Tfp pilus assembly protein FimV - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 411.0
SHD2_k127_2390485_2 Class III cytochrome C family - - - 0.0000000000000000000000000000000000000000000000000000000001816 221.0
SHD2_k127_2390485_3 - - - - 0.000000000000000000000000000000000000000000000000000002025 210.0
SHD2_k127_2390485_4 - - - - 0.0000000000000000000000000000000000000000000000000004417 194.0
SHD2_k127_2390485_5 Contains one ATP-binding region, ATPase-like domain (IPR003594) - - - 0.00000000000000000000000000000000000000000000002305 189.0
SHD2_k127_2390485_6 cheY-homologous receiver domain - - - 0.0000000000000000000000001618 110.0
SHD2_k127_2390485_7 HWE histidine kinase - - - 0.00000000000000000000003726 114.0
SHD2_k127_2390485_8 - - - - 0.0000000000000001519 88.0
SHD2_k127_2390485_9 Endonuclease Exonuclease Phosphatase - - - 0.00000000000000017 95.0
SHD2_k127_2473496_0 TonB-dependent receptor - - - 4.674e-241 767.0
SHD2_k127_2473496_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 344.0
SHD2_k127_2473496_2 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 299.0
SHD2_k127_2473496_3 Domain of unknown function (DUF4384) - - - 0.0002364 52.0
SHD2_k127_248081_0 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.571e-210 695.0
SHD2_k127_248081_1 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 618.0
SHD2_k127_248081_2 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 536.0
SHD2_k127_248081_3 Tellurite resistance protein TehB - - - 0.000000000000000000000001045 110.0
SHD2_k127_248081_4 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.00000000000001843 85.0
SHD2_k127_248081_5 general stress protein - - - 0.000000000001207 75.0
SHD2_k127_2496685_0 LVIVD repeat - - - 4.618e-231 737.0
SHD2_k127_2496685_1 Nickel-dependent hydrogenase K06281 - 1.12.99.6 1.737e-225 714.0
SHD2_k127_2496685_10 Tetratricopeptide repeat K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000006258 226.0
SHD2_k127_2496685_11 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000001668 201.0
SHD2_k127_2496685_12 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000008807 192.0
SHD2_k127_2496685_13 Protein of unknown function (DUF541) K09797 - - 0.0000000000000000000000000000000000000000000000000011 192.0
SHD2_k127_2496685_14 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000001653 205.0
SHD2_k127_2496685_15 Domain of unknown function (DUF4142) - - - 0.00000000000000000000000000000000000000000000000000595 193.0
SHD2_k127_2496685_16 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000001316 191.0
SHD2_k127_2496685_17 respiratory electron transport chain K03620 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.0000000000000000000000000000000000000000002613 170.0
SHD2_k127_2496685_18 Protein of unknown function (DUF1097) - - - 0.0000000000000000000000000000000000000393 153.0
SHD2_k127_2496685_19 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000001257 148.0
SHD2_k127_2496685_2 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 599.0
SHD2_k127_2496685_20 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000003082 127.0
SHD2_k127_2496685_21 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000002217 119.0
SHD2_k127_2496685_22 Lytic transglycosylase catalytic K08307 - - 0.00000000000000000000000004594 117.0
SHD2_k127_2496685_23 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000002128 108.0
SHD2_k127_2496685_24 Belongs to the carbamoyltransferase HypF family K04656 - - 0.00000000000000000007816 100.0
SHD2_k127_2496685_25 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000938 57.0
SHD2_k127_2496685_3 small subunit K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 436.0
SHD2_k127_2496685_4 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 338.0
SHD2_k127_2496685_5 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 291.0
SHD2_k127_2496685_6 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000011 282.0
SHD2_k127_2496685_7 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000003556 237.0
SHD2_k127_2496685_8 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000001029 229.0
SHD2_k127_2496685_9 COG3209 Rhs family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001229 243.0
SHD2_k127_2572779_0 - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - 5.987e-296 981.0
SHD2_k127_2572779_1 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 424.0
SHD2_k127_2572779_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 331.0
SHD2_k127_2572779_3 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 306.0
SHD2_k127_2572779_4 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006689 282.0
SHD2_k127_2572779_5 Peptidase M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000002212 237.0
SHD2_k127_2587447_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0 1129.0
SHD2_k127_2587447_1 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 478.0
SHD2_k127_2587447_2 KR domain K07124 - - 0.0000000000000000000000000000000000000000000000000008583 207.0
SHD2_k127_2621052_0 Multicopper oxidase K22348 - 1.16.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 444.0
SHD2_k127_2621052_1 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 431.0
SHD2_k127_2621052_2 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 420.0
SHD2_k127_2621052_3 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 382.0
SHD2_k127_2621052_4 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 389.0
SHD2_k127_2621052_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001794 278.0
SHD2_k127_2624658_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1260.0
SHD2_k127_2624658_1 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003912 485.0
SHD2_k127_2624658_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 402.0
SHD2_k127_2624658_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000001634 158.0
SHD2_k127_2624658_4 Outer membrane lipoprotein K05807 - - 0.00000000000000000000000000000000001896 149.0
SHD2_k127_2624658_5 Tetratricopeptide repeat - - - 0.0000000000000002576 91.0
SHD2_k127_2641695_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1600.0
SHD2_k127_2641695_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 555.0
SHD2_k127_2641695_2 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 436.0
SHD2_k127_2641695_3 ACT domain K12524 - 1.1.1.3,2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 422.0
SHD2_k127_2641695_4 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 399.0
SHD2_k127_2641695_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 321.0
SHD2_k127_2641695_6 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000001461 226.0
SHD2_k127_2641695_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000001562 128.0
SHD2_k127_2641695_8 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000000000005193 128.0
SHD2_k127_271008_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 394.0
SHD2_k127_271008_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005767 269.0
SHD2_k127_271008_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000002079 218.0
SHD2_k127_271008_3 PFAM PEGA domain - - - 0.0000001828 63.0
SHD2_k127_271008_4 SnoaL-like domain - - - 0.00003972 53.0
SHD2_k127_2721291_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 471.0
SHD2_k127_2721291_1 Protein of unknown function (DUF933) K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 449.0
SHD2_k127_2721291_10 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000001389 168.0
SHD2_k127_2721291_11 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000241 100.0
SHD2_k127_2721291_12 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000001303 103.0
SHD2_k127_2721291_13 TIGRFAM DAK2 domain fusion protein YloV K07030 - - 0.00000000000000001196 85.0
SHD2_k127_2721291_14 - - - - 0.00000000000001374 88.0
SHD2_k127_2721291_15 - - - - 0.00006764 51.0
SHD2_k127_2721291_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004155 282.0
SHD2_k127_2721291_3 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002714 228.0
SHD2_k127_2721291_4 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000001131 203.0
SHD2_k127_2721291_5 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000008845 183.0
SHD2_k127_2721291_6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000001193 180.0
SHD2_k127_2721291_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000001323 163.0
SHD2_k127_2721291_8 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000002535 167.0
SHD2_k127_2721291_9 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000001123 159.0
SHD2_k127_2736335_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 587.0
SHD2_k127_2736335_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 533.0
SHD2_k127_2736335_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004334 270.0
SHD2_k127_2736335_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000102 108.0
SHD2_k127_2736335_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000004502 56.0
SHD2_k127_2746463_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 504.0
SHD2_k127_2746463_1 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008312 397.0
SHD2_k127_2746463_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 385.0
SHD2_k127_2746463_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 372.0
SHD2_k127_2746463_4 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 345.0
SHD2_k127_2746463_5 creatininase K01470,K22232 - 3.5.2.10 0.000000000000000000000000003842 131.0
SHD2_k127_2746463_6 Belongs to the ompA family - - - 0.0000000000000000000000001155 117.0
SHD2_k127_2746463_7 MacB-like periplasmic core domain K02004 - - 0.000000000000000000004305 94.0
SHD2_k127_2746463_8 Belongs to the glycosyl hydrolase 18 family - - - 0.00000000000000003188 94.0
SHD2_k127_2746463_9 Outer membrane efflux protein - - - 0.000276 53.0
SHD2_k127_2749699_0 Participates in both transcription termination and antitermination K02600 - - 3.769e-195 617.0
SHD2_k127_2749699_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 577.0
SHD2_k127_2749699_2 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000002346 135.0
SHD2_k127_2749699_3 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000002352 117.0
SHD2_k127_2749699_4 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - 0.000000000001788 74.0
SHD2_k127_2749699_5 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00026 50.0
SHD2_k127_2768191_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 408.0
SHD2_k127_2768191_1 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000017 141.0
SHD2_k127_2768191_2 heat shock protein binding - - - 0.000003951 54.0
SHD2_k127_2835024_0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 316.0
SHD2_k127_2835024_1 PFAM ABC transporter related K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000004065 254.0
SHD2_k127_2835024_2 ATPase-coupled sulfate transmembrane transporter activity K15496 - - 0.0000000000000000000000000000000000000000000000000000000000000001055 231.0
SHD2_k127_2835024_3 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000003399 230.0
SHD2_k127_2835024_4 Ferritin-like domain K02217 - 1.16.3.2 0.0000000000000000000000000000000000000000000000005694 191.0
SHD2_k127_2835024_5 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.00000000000000000000000000000000000000000004579 177.0
SHD2_k127_2835024_6 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.000000000000000000000000000000000003396 154.0
SHD2_k127_2835024_7 PFAM Cytochrome c, class I - - - 0.00000000000000000000000000002289 126.0
SHD2_k127_2835024_8 haloacid dehalogenase-like hydrolase - - - 0.00000000000002496 85.0
SHD2_k127_2890009_0 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 507.0
SHD2_k127_2890009_1 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 389.0
SHD2_k127_2890009_10 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000001227 97.0
SHD2_k127_2890009_11 - - - - 0.0000000000000001875 92.0
SHD2_k127_2890009_2 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000577 380.0
SHD2_k127_2890009_3 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 310.0
SHD2_k127_2890009_4 NAD(P)H quinone oxidoreductase, PIG3 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 300.0
SHD2_k127_2890009_5 - K12065 - - 0.000000000000000000000000000000000000000000000000000000000000002482 231.0
SHD2_k127_2890009_6 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000005314 197.0
SHD2_k127_2890009_7 converts alpha-aldose to the beta-anomer - - - 0.00000000000000000000000000000006552 139.0
SHD2_k127_2890009_8 - - - - 0.000000000000000000000000003044 128.0
SHD2_k127_2890009_9 PFAM FMN-binding domain protein - - - 0.0000000000000000061 96.0
SHD2_k127_2943107_0 COG0433 Predicted ATPase K06915 - - 3.3e-250 790.0
SHD2_k127_2943107_1 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000007969 100.0
SHD2_k127_2943107_2 COGs COG2380 conserved - - - 0.00000000008417 63.0
SHD2_k127_2974140_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 550.0
SHD2_k127_2974140_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005809 370.0
SHD2_k127_2974140_2 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008899 291.0
SHD2_k127_2974141_0 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 502.0
SHD2_k127_2974141_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 464.0
SHD2_k127_2974141_2 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 399.0
SHD2_k127_2974141_3 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000001148 266.0
SHD2_k127_2974141_4 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000116 254.0
SHD2_k127_2974141_5 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000937 220.0
SHD2_k127_2974141_6 - K07071 - - 0.00000000000000000000000000000000001363 138.0
SHD2_k127_2974141_7 - - - - 0.0000000000000000000001423 112.0
SHD2_k127_2974141_8 - - - - 0.0000003106 59.0
SHD2_k127_298326_0 Helix-hairpin-helix motif K02337 - 2.7.7.7 6.424e-241 761.0
SHD2_k127_298326_1 tRNA synthetases class I (M) K01874 - 6.1.1.10 1.187e-210 665.0
SHD2_k127_298326_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 430.0
SHD2_k127_298326_3 PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004168 300.0
SHD2_k127_298326_4 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000006442 170.0
SHD2_k127_2983305_0 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007753 447.0
SHD2_k127_2983305_1 phosphate ion binding K02040 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 363.0
SHD2_k127_2983305_10 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.0000000000000000000000000003858 119.0
SHD2_k127_2983305_11 - - - - 0.00000000000000001723 96.0
SHD2_k127_2983305_2 HAMP domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 365.0
SHD2_k127_2983305_3 Pfam Phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 347.0
SHD2_k127_2983305_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 325.0
SHD2_k127_2983305_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 336.0
SHD2_k127_2983305_6 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 326.0
SHD2_k127_2983305_7 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 310.0
SHD2_k127_2983305_8 Phosphate transport system permease protein PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001833 300.0
SHD2_k127_2983305_9 negative regulation of phosphate transmembrane transport K02039 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000000000001139 242.0
SHD2_k127_298650_0 GNAT family acetyltransferase K03802 - 6.3.2.29,6.3.2.30 0.0 1343.0
SHD2_k127_298650_1 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 2.106e-221 707.0
SHD2_k127_298650_2 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01305,K01443 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008270,GO:0008798,GO:0016787,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 505.0
SHD2_k127_298650_3 Mur ligase family, glutamate ligase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 462.0
SHD2_k127_298650_4 Peptidase family S51 K13282 - 3.4.15.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008511 365.0
SHD2_k127_298650_5 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001037 278.0
SHD2_k127_298650_6 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000009055 134.0
SHD2_k127_3039827_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 576.0
SHD2_k127_3039827_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005186 512.0
SHD2_k127_3039827_2 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009063 391.0
SHD2_k127_3039827_3 GIY-YIG type nucleases (URI domain) K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002673 284.0
SHD2_k127_3039827_4 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000005601 247.0
SHD2_k127_3039827_5 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000015 213.0
SHD2_k127_3077377_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 583.0
SHD2_k127_3077377_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 338.0
SHD2_k127_3077377_10 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000009616 143.0
SHD2_k127_3077377_11 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000006875 123.0
SHD2_k127_3077377_12 AraC-like ligand binding domain - - - 0.000000000000000000000000002451 115.0
SHD2_k127_3077377_13 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000004894 111.0
SHD2_k127_3077377_14 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000001067 119.0
SHD2_k127_3077377_15 - - - - 0.0000000000000000000002078 111.0
SHD2_k127_3077377_16 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000007158 104.0
SHD2_k127_3077377_17 Ribosomal protein S16 K02959 - - 0.000000000000000000001663 96.0
SHD2_k127_3077377_18 - - - - 0.000000000000000000007729 103.0
SHD2_k127_3077377_19 - - - - 0.0000000000000000000187 97.0
SHD2_k127_3077377_2 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 294.0
SHD2_k127_3077377_20 Large extracellular alpha-helical protein K12548,K13735 - - 0.00000000000000000002565 104.0
SHD2_k127_3077377_21 - - - - 0.0000000002917 69.0
SHD2_k127_3077377_22 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000001058 56.0
SHD2_k127_3077377_23 - - - - 0.000007465 55.0
SHD2_k127_3077377_24 Protein of unknown function (DUF1697) - - - 0.00005419 53.0
SHD2_k127_3077377_3 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002244 285.0
SHD2_k127_3077377_4 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003785 260.0
SHD2_k127_3077377_5 response regulator K07782 - - 0.0000000000000000000000000000000000000000000000000000000000000004142 236.0
SHD2_k127_3077377_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000003571 201.0
SHD2_k127_3077377_7 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000164 214.0
SHD2_k127_3077377_8 - - - - 0.00000000000000000000000000000000000000000000004463 193.0
SHD2_k127_3077377_9 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000005904 163.0
SHD2_k127_3080151_0 Peptidase family M1 domain - - - 1.414e-228 720.0
SHD2_k127_3080151_1 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 325.0
SHD2_k127_3080151_2 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002117 258.0
SHD2_k127_3080151_3 DinB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003397 246.0
SHD2_k127_3080151_4 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000004006 205.0
SHD2_k127_3080151_5 Amidohydrolase family K01487 - 3.5.4.3 0.0000000000000000000000000000000000000000005369 161.0
SHD2_k127_3080151_6 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000007964 101.0
SHD2_k127_3138137_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1189.0
SHD2_k127_3138137_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 569.0
SHD2_k127_3138137_10 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000155 267.0
SHD2_k127_3138137_11 Ion transport 2 domain protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000003127 248.0
SHD2_k127_3138137_12 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000006848 213.0
SHD2_k127_3138137_13 diguanylate cyclase - - - 0.00000000000000000000000000000000537 146.0
SHD2_k127_3138137_14 Fimbrial assembly protein (PilN) - - - 0.00000000000000000000000000000001047 136.0
SHD2_k127_3138137_15 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000001295 116.0
SHD2_k127_3138137_16 Pilus assembly protein, PilO K02664 - - 0.000000000000000000009001 100.0
SHD2_k127_3138137_17 - - - - 0.000000000000000001243 96.0
SHD2_k127_3138137_2 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 553.0
SHD2_k127_3138137_3 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 566.0
SHD2_k127_3138137_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 517.0
SHD2_k127_3138137_5 Type IV pilus assembly protein PilM; K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 450.0
SHD2_k127_3138137_6 AMIN domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 456.0
SHD2_k127_3138137_7 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 409.0
SHD2_k127_3138137_8 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 399.0
SHD2_k127_3138137_9 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 317.0
SHD2_k127_3161643_0 - - - - 0.00000000000000000000000000000000000000000000000000007453 195.0
SHD2_k127_3161643_1 Glycosyl transferase family 2 K08301 - - 0.00000000000000000000000000000000000000000000000003332 202.0
SHD2_k127_3161643_2 PFAM Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000005068 195.0
SHD2_k127_3161643_3 Glycine oxidase K03153 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19 0.0000000000000000000000000000000000000000000000009946 192.0
SHD2_k127_3161643_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000001114 168.0
SHD2_k127_3161643_5 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000004288 151.0
SHD2_k127_3161643_6 Protein of unknown function (DUF1684) K09164 - - 0.00000000000001066 83.0
SHD2_k127_3161643_7 - - - - 0.0002123 47.0
SHD2_k127_3162979_0 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 488.0
SHD2_k127_3162979_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001702 244.0
SHD2_k127_3162979_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000006061 184.0
SHD2_k127_3162979_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K03286 - - 0.0000000000000000000000000000004249 125.0
SHD2_k127_3162979_5 - - - - 0.0000000000000009623 90.0
SHD2_k127_3162979_6 glyoxalase III activity - - - 0.00000000004476 70.0
SHD2_k127_3162979_7 - - - - 0.0000009329 60.0
SHD2_k127_3162979_8 NHL repeat - - - 0.0002928 52.0
SHD2_k127_3180452_0 C-terminus of AA_permease K03294 - - 3.903e-232 727.0
SHD2_k127_3180452_1 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 494.0
SHD2_k127_3180452_2 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004941 325.0
SHD2_k127_3180452_3 - - - - 0.00000006283 61.0
SHD2_k127_3211592_0 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 619.0
SHD2_k127_3211592_1 cystathionine K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 488.0
SHD2_k127_3211592_2 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006765 282.0
SHD2_k127_3211592_3 - - - - 0.000000000000000000000000000000000000000000000000000000000001048 221.0
SHD2_k127_3211592_4 GYD domain - - - 0.0000000000001385 81.0
SHD2_k127_3261261_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000625 617.0
SHD2_k127_3261261_1 Putative adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000001679 249.0
SHD2_k127_3261261_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000002603 114.0
SHD2_k127_3261261_3 sensor histidine kinase response - - - 0.00000000000000001805 89.0
SHD2_k127_3261261_4 4-vinyl reductase, 4VR - - - 0.0000000000000000482 89.0
SHD2_k127_3288135_0 imidazolonepropionase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 546.0
SHD2_k127_3288135_1 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 420.0
SHD2_k127_3288135_2 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 340.0
SHD2_k127_3294859_0 Ketoacyl-synthetase C-terminal extension - - - 0.0 1778.0
SHD2_k127_3294859_1 Non-ribosomal peptide synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 473.0
SHD2_k127_3318824_0 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 454.0
SHD2_k127_3318824_1 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 319.0
SHD2_k127_3318824_2 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004419 271.0
SHD2_k127_3318824_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003159 264.0
SHD2_k127_3318824_4 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000009159 239.0
SHD2_k127_3318824_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000000002039 209.0
SHD2_k127_3318824_6 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000001431 179.0
SHD2_k127_3318824_7 SMART metal-dependent phosphohydrolase, HD region K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000007839 190.0
SHD2_k127_3318824_8 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000001699 62.0
SHD2_k127_3339826_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 578.0
SHD2_k127_3339826_1 Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 516.0
SHD2_k127_3339826_10 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000001448 157.0
SHD2_k127_3339826_11 Regulatory protein, FmdB family - - - 0.000000000000000000007278 96.0
SHD2_k127_3339826_12 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000009571 98.0
SHD2_k127_3339826_2 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 439.0
SHD2_k127_3339826_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 405.0
SHD2_k127_3339826_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 410.0
SHD2_k127_3339826_5 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 364.0
SHD2_k127_3339826_6 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 338.0
SHD2_k127_3339826_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 309.0
SHD2_k127_3339826_8 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000004709 214.0
SHD2_k127_3339826_9 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000007191 201.0
SHD2_k127_334946_0 Formate dehydrogenase subunit alpha - - - 0.0 1274.0
SHD2_k127_334946_1 COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - - 1.544e-202 648.0
SHD2_k127_334946_2 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 450.0
SHD2_k127_334946_3 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 414.0
SHD2_k127_334946_4 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009518 265.0
SHD2_k127_334946_5 Bacterial transferase hexapeptide (six repeats) K13006 - - 0.000000000000000000000000000000000000000000000000000000000000001714 231.0
SHD2_k127_334946_6 COG NOG14600 non supervised orthologous group - - - 0.000000000000000000000000000000000000000000001854 166.0
SHD2_k127_334946_7 CBS domain - - - 0.00000000000000000000000003629 127.0
SHD2_k127_334946_8 Trm112p-like protein K09791 - - 0.000000000000000002396 97.0
SHD2_k127_334946_9 ATPase family associated with various cellular activities (AAA) K03696 - - 0.000000009177 67.0
SHD2_k127_3355309_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 8.29e-296 928.0
SHD2_k127_3355309_1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 386.0
SHD2_k127_3355309_2 PFAM DivIVA protein K04074 - - 0.000000000000002723 84.0
SHD2_k127_3355309_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000003867 63.0
SHD2_k127_3362501_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 1.888e-214 691.0
SHD2_k127_3362501_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 486.0
SHD2_k127_3362501_2 Anthranilate synthase component I K01657,K01665,K13950 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 400.0
SHD2_k127_3362501_3 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001501 273.0
SHD2_k127_3362501_4 PFAM glutamine amidotransferase class-I K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000002433 247.0
SHD2_k127_3362501_5 Pterin 4 alpha carbinolamine dehydratase K01724,K11991 - 3.5.4.33,4.2.1.96 0.00000000000000000000000000000000000000000002858 164.0
SHD2_k127_3362501_6 Protein of unknown function (DUF447) K09154 - - 0.000000000000000000000000000000000000000000144 183.0
SHD2_k127_3362501_7 TIGRFAM beta-ribofuranosylaminobenzene 5'-phosphate synthase family - - - 0.00000000000000000000000000000000000000003721 171.0
SHD2_k127_3362501_8 lyase activity K09733 - 4.2.3.153 0.000000000000000000000000007481 121.0
SHD2_k127_3362501_9 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000002122 108.0
SHD2_k127_3448169_0 Proto-chlorophyllide reductase 57 kD subunit K04039 - 1.3.7.7 4.135e-212 690.0
SHD2_k127_3448169_1 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex K04038 - 1.3.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 613.0
SHD2_k127_3448169_10 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000207 273.0
SHD2_k127_3448169_11 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004006 260.0
SHD2_k127_3448169_12 2-vinyl bacteriochlorophyllide hydratase K11336 GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.165 0.00000000000000000000000000000000000000000000000000000000000000001205 228.0
SHD2_k127_3448169_13 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008729 230.0
SHD2_k127_3448169_14 PFAM TspO MBR family protein K05770 - - 0.00000000000000000000000000000000000000000179 172.0
SHD2_k127_3448169_15 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000003444 106.0
SHD2_k127_3448169_16 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000001614 64.0
SHD2_k127_3448169_2 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K21231 - 1.12.98.1,1.3.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006915 524.0
SHD2_k127_3448169_3 Lycopene cyclase protein K10960,K21401 - 1.3.1.111,1.3.1.83,1.3.99.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 542.0
SHD2_k127_3448169_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008727 507.0
SHD2_k127_3448169_5 phosphorelay signal transduction system K03413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 500.0
SHD2_k127_3448169_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008821 405.0
SHD2_k127_3448169_7 Coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 413.0
SHD2_k127_3448169_8 UbiA prenyltransferase family K04040 - 2.5.1.133,2.5.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 349.0
SHD2_k127_3448169_9 PFAM PUCC protein K08226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 355.0
SHD2_k127_3466850_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 534.0
SHD2_k127_3466850_1 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004964 507.0
SHD2_k127_3466850_2 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007284 280.0
SHD2_k127_3466850_3 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000003864 227.0
SHD2_k127_3466850_4 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000002648 186.0
SHD2_k127_3466850_5 Sporulation related domain - - - 0.000000000000005649 87.0
SHD2_k127_3466850_6 DUF218 domain - - - 0.00000000003329 65.0
SHD2_k127_349980_0 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004627 540.0
SHD2_k127_349980_1 coenzyme F420 hydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 377.0
SHD2_k127_349980_2 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 372.0
SHD2_k127_349980_3 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002394 260.0
SHD2_k127_349980_4 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000000000000000000000001638 201.0
SHD2_k127_349980_5 Hydrogenase maturation protease - - - 0.000008046 58.0
SHD2_k127_3511600_0 DNA ligase N terminus K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.95e-204 679.0
SHD2_k127_3511600_1 Exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 495.0
SHD2_k127_3511600_2 TonB-dependent receptor - - - 0.000000000000000000000000000000000004862 160.0
SHD2_k127_3511600_3 membrane transporter protein K07090 - - 0.0000000000000000000000000000000938 128.0
SHD2_k127_3511600_5 salt-induced outer membrane protein K07283 - - 0.000034 54.0
SHD2_k127_3511600_6 Protein of unknown function (DUF1499) - - - 0.0003443 52.0
SHD2_k127_3622833_0 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000000000000000000000000000000000000006504 235.0
SHD2_k127_3622833_1 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity K16038 GO:0002682,GO:0002684,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0030312,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 - 0.00000000000000000000000000000000000000000000000000000000000079 228.0
SHD2_k127_3622833_10 Domain of unknown function (DUF4440) - - - 0.000000002482 66.0
SHD2_k127_3622833_11 - - - - 0.00011 54.0
SHD2_k127_3622833_3 SnoaL-like domain - - - 0.0000000000000000000000000000000001371 138.0
SHD2_k127_3622833_4 - - - - 0.0000000000000000000000000000000004327 151.0
SHD2_k127_3622833_5 - - - - 0.0000000000000000000000000000000129 144.0
SHD2_k127_3622833_6 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000000003986 130.0
SHD2_k127_3622833_7 - - - - 0.000000000000000000000000001165 124.0
SHD2_k127_3622833_8 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000001454 106.0
SHD2_k127_3622833_9 - - - - 0.000000000002358 78.0
SHD2_k127_3623587_0 Belongs to the glycosyl hydrolase 13 family K01214,K02438 - 3.2.1.196,3.2.1.68 2.221e-202 652.0
SHD2_k127_3623587_1 DNA synthesis involved in double-strand break repair via homologous recombination K07455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003181 267.0
SHD2_k127_3623587_2 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000000000000000004882 186.0
SHD2_k127_3623587_3 UPF0365 protein - - - 0.0000000000000000000000000000000000001133 143.0
SHD2_k127_3623587_4 Protein of unknown function, DUF393 - - - 0.0000000000000000000000000000007836 125.0
SHD2_k127_3665928_0 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 506.0
SHD2_k127_3665928_1 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 427.0
SHD2_k127_3665928_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000007426 275.0
SHD2_k127_3665928_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000005118 229.0
SHD2_k127_3717082_0 DEAD/H associated K03724 - - 0.0 1133.0
SHD2_k127_3717082_1 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 536.0
SHD2_k127_3717082_2 Ring hydroxylating alpha subunit (catalytic domain) K00479 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 370.0
SHD2_k127_3717082_3 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 361.0
SHD2_k127_3717082_4 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006035 355.0
SHD2_k127_3717082_5 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000003843 235.0
SHD2_k127_3717082_6 DinB family - - - 0.00000000000000000000000000002626 122.0
SHD2_k127_3776467_0 Amidohydrolase family K06015 - 3.5.1.81 1.421e-217 689.0
SHD2_k127_3776467_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 413.0
SHD2_k127_3776467_2 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000009773 206.0
SHD2_k127_3776467_3 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.000000000000000000000000000000000000000000000000000000009985 218.0
SHD2_k127_3776467_4 acetyltransferase K18816 - 2.3.1.82 0.00000000000000000000000000000000000000000000001943 176.0
SHD2_k127_3776467_5 - - - - 0.0000000000000000000000000000000000000000000001107 178.0
SHD2_k127_3776467_6 - - - - 0.0000000000000000000000000000001503 131.0
SHD2_k127_3776467_7 lactoylglutathione lyase activity - - - 0.00000000000000000000006865 115.0
SHD2_k127_3776467_9 cytochrome c oxidase K00406 - - 0.0001088 51.0
SHD2_k127_3783663_0 Ammonium Transporter K03320 - - 1.708e-194 616.0
SHD2_k127_3783663_1 Psort location CytoplasmicMembrane, score 10.00 K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002676 284.0
SHD2_k127_3783663_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000001756 262.0
SHD2_k127_3783663_3 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000001717 227.0
SHD2_k127_3783663_4 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000384 214.0
SHD2_k127_3783663_5 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000006261 196.0
SHD2_k127_3783663_6 ABC transporter K02017,K15497 - 3.6.3.29,3.6.3.55 0.000000000000000000000000000000000000000000000000006778 188.0
SHD2_k127_3783663_7 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000008826 173.0
SHD2_k127_3783663_8 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000001504 149.0
SHD2_k127_3783663_9 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0000000000000000000001209 112.0
SHD2_k127_384335_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1092.0
SHD2_k127_384335_1 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 389.0
SHD2_k127_384335_10 - - - - 0.0000000000000000000000000001033 134.0
SHD2_k127_384335_11 Methyl-accepting chemotaxis protein (MCP) signalling domain - - - 0.0000000000000000000000005264 119.0
SHD2_k127_384335_2 Sodium:sulfate symporter transmembrane region K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 351.0
SHD2_k127_384335_3 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 296.0
SHD2_k127_384335_4 N-terminal domain of Peptidase_S41 in eukaryotic IRBP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001722 285.0
SHD2_k127_384335_5 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004568 271.0
SHD2_k127_384335_6 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000002229 185.0
SHD2_k127_384335_7 Vitamin K epoxide reductase family - - - 0.0000000000000000000000000000000000000004811 154.0
SHD2_k127_384335_8 glyoxalase III activity - - - 0.0000000000000000000000000000000003913 139.0
SHD2_k127_384335_9 Cold shock K03704 - - 0.0000000000000000000000000000000006521 130.0
SHD2_k127_3866689_0 PFAM sodium hydrogen exchanger K03316 - - 3.069e-198 631.0
SHD2_k127_3866689_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 481.0
SHD2_k127_3866689_2 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 470.0
SHD2_k127_3866689_3 amino acid K20265 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 469.0
SHD2_k127_3866689_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 382.0
SHD2_k127_3866689_5 PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 400.0
SHD2_k127_3866689_7 Protein of unknown function (DUF1254) - - - 0.0002445 46.0
SHD2_k127_3872344_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 471.0
SHD2_k127_3872344_1 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 319.0
SHD2_k127_3872344_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 314.0
SHD2_k127_3872344_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01450,K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.31,3.5.1.88 0.000000000000000000000000000000000000000001374 170.0
SHD2_k127_3872344_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000001236 109.0
SHD2_k127_3872344_5 DinB superfamily - - - 0.00000000000002026 78.0
SHD2_k127_3872344_6 thiamine biosynthesis protein ThiS K03154 - - 0.0000000000001836 81.0
SHD2_k127_3872344_7 COG1862 Preprotein translocase subunit YajC K03210 - - 0.000000000009702 70.0
SHD2_k127_3879833_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 537.0
SHD2_k127_3879833_1 - - - - 0.000000000000000000000004384 115.0
SHD2_k127_3879833_2 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000695 85.0
SHD2_k127_3879833_3 PFAM Late competence development protein ComFB K02241 - - 0.0000001509 61.0
SHD2_k127_3894232_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 2.205e-307 990.0
SHD2_k127_3894232_1 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 1.268e-261 841.0
SHD2_k127_3894232_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 345.0
SHD2_k127_3894232_3 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005443 284.0
SHD2_k127_3895230_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 524.0
SHD2_k127_3895230_1 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 458.0
SHD2_k127_3895230_2 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 402.0
SHD2_k127_3895230_3 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 302.0
SHD2_k127_3895230_4 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000005933 213.0
SHD2_k127_3896416_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.221e-267 841.0
SHD2_k127_3896416_1 secondary active sulfate transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 316.0
SHD2_k127_3896416_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K00950,K01633 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 0.00000000000000000000000000000000000000000000000000000000000000000004053 257.0
SHD2_k127_3896416_3 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000007303 226.0
SHD2_k127_3896416_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000009693 163.0
SHD2_k127_3896416_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075 - 2.4.2.8,6.3.4.19 0.0000000000000000000000000000000000001587 156.0
SHD2_k127_3896476_0 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 436.0
SHD2_k127_3896476_1 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 358.0
SHD2_k127_3896476_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000001494 249.0
SHD2_k127_3896476_3 Mazg nucleotide pyrophosphohydrolase K00800 - 2.5.1.19 0.0000000000000000000005236 95.0
SHD2_k127_3896476_4 - - - - 0.00000000001805 73.0
SHD2_k127_3896476_5 phosphorelay signal transduction system - - - 0.0000003236 61.0
SHD2_k127_3925653_0 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 396.0
SHD2_k127_3925653_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 350.0
SHD2_k127_3925653_2 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 320.0
SHD2_k127_3925653_3 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 335.0
SHD2_k127_3925653_4 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000000000001236 174.0
SHD2_k127_3957994_0 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 491.0
SHD2_k127_3957994_1 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 449.0
SHD2_k127_3957994_2 cellular manganese ion homeostasis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000089 379.0
SHD2_k127_3957994_3 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002066 295.0
SHD2_k127_3957994_4 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000005883 120.0
SHD2_k127_3957994_5 Transcriptional - - - 0.00000006948 54.0
SHD2_k127_3957994_6 Protein kinase domain K12132 - 2.7.11.1 0.0001175 53.0
SHD2_k127_3971300_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001444 305.0
SHD2_k127_3971300_1 Rossmann-like domain K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000633 249.0
SHD2_k127_3971300_2 FMN-dependent dehydrogenase K16422 - 1.1.3.46 0.000000000000000000000000000000000000000000004623 179.0
SHD2_k127_3971300_3 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000006778 167.0
SHD2_k127_3971300_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000001467 124.0
SHD2_k127_398758_0 Voltage gated chloride channel K03281 - - 1.382e-228 723.0
SHD2_k127_398758_1 Uncharacterized protein conserved in bacteria (DUF2252) - - - 1.836e-206 653.0
SHD2_k127_398758_10 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000003903 184.0
SHD2_k127_398758_11 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000125 130.0
SHD2_k127_398758_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.000000000000000000000000001425 128.0
SHD2_k127_398758_13 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000001058 98.0
SHD2_k127_398758_14 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K00332 - 1.6.5.3 0.000000000000000000003725 102.0
SHD2_k127_398758_15 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000001545 79.0
SHD2_k127_398758_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.000000004152 67.0
SHD2_k127_398758_2 Aminotransferase class-V - - - 5.73e-204 646.0
SHD2_k127_398758_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 537.0
SHD2_k127_398758_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 445.0
SHD2_k127_398758_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 368.0
SHD2_k127_398758_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 338.0
SHD2_k127_398758_7 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 337.0
SHD2_k127_398758_8 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 325.0
SHD2_k127_398758_9 PFAM YbaK prolyl-tRNA synthetase associated region K19055 - - 0.00000000000000000000000000000000000000000000000000000187 198.0
SHD2_k127_399294_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 433.0
SHD2_k127_399294_1 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 422.0
SHD2_k127_399294_2 Putative zinc-binding metallo-peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 394.0
SHD2_k127_399294_3 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000251 270.0
SHD2_k127_399294_4 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000001933 175.0
SHD2_k127_399294_5 4 iron, 4 sulfur cluster binding K02572,K02573 - - 0.00000000000000000000000000000005533 132.0
SHD2_k127_399294_6 Peptidase family M1 domain K01256 - 3.4.11.2 0.00000000004076 74.0
SHD2_k127_4028559_0 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001242 284.0
SHD2_k127_4028559_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000001969 263.0
SHD2_k127_4028559_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000001252 237.0
SHD2_k127_4028559_3 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000001305 229.0
SHD2_k127_4028559_4 Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000002023 200.0
SHD2_k127_4028559_5 SIS domain K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000001002 175.0
SHD2_k127_4028559_6 protein tyrosine phosphatase activity K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000007381 171.0
SHD2_k127_4045623_0 transmembrane transporter activity K18138 - - 0.0 1326.0
SHD2_k127_4045623_1 - - - - 1.208e-203 677.0
SHD2_k127_4045623_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 377.0
SHD2_k127_4045623_3 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 353.0
SHD2_k127_4045623_4 Domain of unknown function (DUF3943) - - - 0.000000000000000000000000000000000000000000000000000000000004635 228.0
SHD2_k127_4045623_5 response regulator receiver K13041 - - 0.00000000000000000000000000000000000000000000000000485 188.0
SHD2_k127_4045623_6 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000667 181.0
SHD2_k127_4045623_7 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000005792 108.0
SHD2_k127_4074530_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 4.495e-271 844.0
SHD2_k127_4074530_1 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 8.103e-208 675.0
SHD2_k127_4074530_10 PFAM Ammonium Transporter Family K03320 - - 0.00000000000001809 76.0
SHD2_k127_4074530_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007201 609.0
SHD2_k127_4074530_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 448.0
SHD2_k127_4074530_4 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 392.0
SHD2_k127_4074530_5 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 365.0
SHD2_k127_4074530_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000179 245.0
SHD2_k127_4074530_7 Nitrogen regulatory protein P-II K04751 - - 0.00000000000000000000000000000000000000000000000000000001784 199.0
SHD2_k127_4074530_8 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000002211 96.0
SHD2_k127_4074530_9 Acetolactate synthase small K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.000000000000001139 89.0
SHD2_k127_4120099_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 449.0
SHD2_k127_4120099_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 433.0
SHD2_k127_4120099_2 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006931 408.0
SHD2_k127_4120099_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000137 301.0
SHD2_k127_4120099_4 Cell cycle protein K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000636 293.0
SHD2_k127_4120099_5 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007928 298.0
SHD2_k127_4120099_6 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000001268 55.0
SHD2_k127_4139695_0 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 368.0
SHD2_k127_4139695_1 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.000000000000000000000000000000000000000001107 159.0
SHD2_k127_4139695_2 Translation initiation factor SUI1 K03113 - - 0.0000000000000000000000000000000000000007991 160.0
SHD2_k127_4139695_3 - - - - 0.000000000000000000000000000000000000004833 154.0
SHD2_k127_4139695_4 Cold shock K03704 - - 0.000000000000000000000000000000004609 129.0
SHD2_k127_4139695_5 Ribosomal protein S21 K02970 - - 0.00000000007709 66.0
SHD2_k127_4144060_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 8.187e-283 891.0
SHD2_k127_4144060_1 Serine dehydratase beta chain K01752 - 4.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000001525 258.0
SHD2_k127_4144060_2 Serine dehydratase alpha chain K01752 - 4.3.1.17 0.000000000000000000000000000000000000000000005417 178.0
SHD2_k127_4144060_3 LVIVD repeat - - - 0.00000000000000000000007562 106.0
SHD2_k127_4195402_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 4.707e-296 923.0
SHD2_k127_4195402_1 DNA polymerase alpha chain like domain K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 550.0
SHD2_k127_4195402_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 307.0
SHD2_k127_4195402_11 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000001941 244.0
SHD2_k127_4195402_12 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000305 236.0
SHD2_k127_4195402_13 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000006584 242.0
SHD2_k127_4195402_14 Peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000004742 203.0
SHD2_k127_4195402_15 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000006798 205.0
SHD2_k127_4195402_16 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000001072 160.0
SHD2_k127_4195402_17 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000002534 163.0
SHD2_k127_4195402_18 HEAT repeats - - - 0.000000000000000000000000000000000136 151.0
SHD2_k127_4195402_19 GAF domain-containing protein K08968 - 1.8.4.14 0.00000000000000000000002612 115.0
SHD2_k127_4195402_2 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 496.0
SHD2_k127_4195402_20 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000003097 98.0
SHD2_k127_4195402_21 Cysteine-rich CPXCG - - - 0.0000000000000001001 83.0
SHD2_k127_4195402_22 MacB-like periplasmic core domain - - - 0.0000002411 64.0
SHD2_k127_4195402_23 - - - - 0.000008518 54.0
SHD2_k127_4195402_24 - - - - 0.00001869 55.0
SHD2_k127_4195402_3 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 420.0
SHD2_k127_4195402_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 377.0
SHD2_k127_4195402_5 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 360.0
SHD2_k127_4195402_6 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 351.0
SHD2_k127_4195402_7 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 327.0
SHD2_k127_4195402_8 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 302.0
SHD2_k127_4195402_9 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 299.0
SHD2_k127_4204052_0 Polysaccharide biosynthesis/export protein - - - 1.377e-266 844.0
SHD2_k127_4204052_1 CoA-binding domain - - - 4.057e-217 690.0
SHD2_k127_4204052_2 Asparagine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 561.0
SHD2_k127_4204052_3 Glycosyl transferases group 1 K21011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 308.0
SHD2_k127_4204052_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006957 293.0
SHD2_k127_4204052_5 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001807 282.0
SHD2_k127_4204052_6 Male sterility protein K00091,K01784 - 1.1.1.219,5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000004574 262.0
SHD2_k127_4204052_7 PFAM Glycosyl transferase family 4 K02851,K13007 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000001381 183.0
SHD2_k127_4233448_0 isocitrate dehydrogenase activity K00031 GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 1.862e-208 654.0
SHD2_k127_4233448_1 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 537.0
SHD2_k127_4233448_2 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002635 297.0
SHD2_k127_4233448_3 TM2 domain - - - 0.0000000000000000005795 92.0
SHD2_k127_4233448_4 - - - - 0.0000000000001404 72.0
SHD2_k127_4233448_5 - - - - 0.0000000001693 61.0
SHD2_k127_4307672_0 Peptidase family M1 domain - - - 1.68e-239 757.0
SHD2_k127_4307672_1 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 623.0
SHD2_k127_4307672_10 DinB superfamily - - - 0.0000000000000000008879 93.0
SHD2_k127_4307672_11 Protein of unknown function (DUF445) - - - 0.000000001941 58.0
SHD2_k127_4307672_12 protein kinase activity K12132 - 2.7.11.1 0.000000005525 69.0
SHD2_k127_4307672_2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 513.0
SHD2_k127_4307672_3 Cysteine synthase cystathionine beta-synthase family protein K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 435.0
SHD2_k127_4307672_4 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009907 303.0
SHD2_k127_4307672_5 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000000000000000000007464 202.0
SHD2_k127_4307672_6 Protein of unknown function (DUF3011) - - - 0.000000000000000000000000000000000000000000000000004966 195.0
SHD2_k127_4307672_7 coenzyme F420 binding K07226 - - 0.0000000000000000000000003394 111.0
SHD2_k127_4307672_8 D-aminopeptidase K16203 - - 0.0000000000000000000002179 112.0
SHD2_k127_4307672_9 Diacylglycerol kinase K00901 - 2.7.1.107 0.0000000000000000000002948 111.0
SHD2_k127_4309697_0 DNA helicase K03654 - 3.6.4.12 8.382e-233 737.0
SHD2_k127_4309697_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008513 516.0
SHD2_k127_4309697_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006833 316.0
SHD2_k127_4309697_3 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000105 188.0
SHD2_k127_4309697_4 Putative thioesterase (yiiD_Cterm) - - - 0.000000000000000000000000000000004692 134.0
SHD2_k127_4309697_5 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000001096 128.0
SHD2_k127_4309697_6 - - - - 0.00000000000000000000000000001964 122.0
SHD2_k127_4309697_7 acetyltransferase - - - 0.00000000000000000008667 102.0
SHD2_k127_4309697_8 - - - - 0.00000000000000006845 88.0
SHD2_k127_4309697_9 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase K07006 - - 0.000000004244 64.0
SHD2_k127_4318888_0 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000009053 155.0
SHD2_k127_4318888_2 aminopeptidase activity - - - 0.00000000000104 70.0
SHD2_k127_4318888_3 Bacterial transcriptional activator domain - - - 0.0000000001776 74.0
SHD2_k127_4348084_0 Carboxyl transferase domain - - - 8.596e-240 764.0
SHD2_k127_4348084_1 Sulfate permease family K03321 - - 1.282e-205 653.0
SHD2_k127_4348084_2 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 387.0
SHD2_k127_4348084_3 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 354.0
SHD2_k127_4348084_4 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001536 271.0
SHD2_k127_4348084_5 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.00000000000000000000000000000000000000000000000009756 195.0
SHD2_k127_4348084_6 CBS domain containing protein K06189 - - 0.00000000000000000000000000000000000007155 156.0
SHD2_k127_4348084_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.0000000000000000000000000000000000005442 148.0
SHD2_k127_4348084_8 Outer membrane protein beta-barrel domain - - - 0.000001127 59.0
SHD2_k127_4350175_0 COG0493 NADPH-dependent glutamate synthase beta chain and related K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 502.0
SHD2_k127_4350175_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 322.0
SHD2_k127_4350175_2 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000002303 233.0
SHD2_k127_4350175_3 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000006349 199.0
SHD2_k127_4350175_4 Peptidase family M28 - - - 0.0000000000002478 73.0
SHD2_k127_4350898_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 1.392e-216 701.0
SHD2_k127_4350898_1 Alcohol dehydrogenase GroES-like domain K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006298 522.0
SHD2_k127_4350898_10 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000002542 119.0
SHD2_k127_4350898_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000001505 129.0
SHD2_k127_4350898_12 Sugar (and other) transporter - - - 0.000000000000000000000001173 107.0
SHD2_k127_4350898_14 response to abiotic stimulus - - - 0.00000000419 68.0
SHD2_k127_4350898_15 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.000001495 49.0
SHD2_k127_4350898_2 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 441.0
SHD2_k127_4350898_3 PFAM pyridoxamine 5-phosphate K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006971 280.0
SHD2_k127_4350898_4 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000719 240.0
SHD2_k127_4350898_5 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000001157 241.0
SHD2_k127_4350898_6 MOSC domain - - - 0.00000000000000000000000000000000000000000000000000001891 196.0
SHD2_k127_4350898_7 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000000002078 183.0
SHD2_k127_4350898_8 - - - - 0.000000000000000000000000000000000003298 143.0
SHD2_k127_4350898_9 YCII-related domain K09780 - - 0.00000000000000000000000000000000004743 153.0
SHD2_k127_4351593_0 Luciferase-like monooxygenase - - - 1.478e-307 977.0
SHD2_k127_437072_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 608.0
SHD2_k127_437072_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 521.0
SHD2_k127_437072_10 CAAX protease self-immunity K07052 - - 0.0000000000000000001745 91.0
SHD2_k127_437072_11 Septum formation initiator K05589 - - 0.00000002594 66.0
SHD2_k127_437072_12 KR domain K07124 - - 0.000003497 51.0
SHD2_k127_437072_13 diguanylate cyclase - - - 0.00001785 57.0
SHD2_k127_437072_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 413.0
SHD2_k127_437072_3 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 384.0
SHD2_k127_437072_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000002365 275.0
SHD2_k127_437072_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000001312 233.0
SHD2_k127_437072_6 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000003397 196.0
SHD2_k127_437072_7 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000001916 184.0
SHD2_k127_437072_8 - - - - 0.0000000000000000000000000000000000000000126 157.0
SHD2_k127_437072_9 - - - - 0.00000000000000000000000008691 114.0
SHD2_k127_4455335_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 573.0
SHD2_k127_4455335_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000002028 203.0
SHD2_k127_4455335_2 EVE domain - - - 0.0000000000000000000000000000000000000000000000002205 179.0
SHD2_k127_4533751_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.165e-248 786.0
SHD2_k127_4533751_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 505.0
SHD2_k127_4533751_10 Roadblock/LC7 domain - - - 0.00000000000000000000000000000000000000000000000000000001357 207.0
SHD2_k127_4533751_12 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000002747 161.0
SHD2_k127_4533751_13 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000001423 134.0
SHD2_k127_4533751_14 PFAM membrane protein of K08972 - - 0.000000000000000000000006304 105.0
SHD2_k127_4533751_15 Virulence factor BrkB K07058 - - 0.0000000001138 73.0
SHD2_k127_4533751_16 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000002055 60.0
SHD2_k127_4533751_17 YtxH-like protein - - - 0.00003487 52.0
SHD2_k127_4533751_2 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 483.0
SHD2_k127_4533751_3 Phosphoglucose isomerase K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 425.0
SHD2_k127_4533751_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 410.0
SHD2_k127_4533751_5 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 377.0
SHD2_k127_4533751_6 Competence-damaged protein K03742 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 388.0
SHD2_k127_4533751_7 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 365.0
SHD2_k127_4533751_8 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 329.0
SHD2_k127_4533751_9 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000001062 241.0
SHD2_k127_4554045_0 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 533.0
SHD2_k127_4554045_1 Tellurite resistance protein TehB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001089 253.0
SHD2_k127_4554045_10 Cytochrome c' - - - 0.0002086 51.0
SHD2_k127_4554045_11 - - - - 0.0002612 52.0
SHD2_k127_4554045_2 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000009877 226.0
SHD2_k127_4554045_3 Protein of unknown function (DUF1194) K07114 - - 0.0000000000000000000000000000000000000000000000000000000007015 217.0
SHD2_k127_4554045_4 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000366 185.0
SHD2_k127_4554045_5 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000003091 188.0
SHD2_k127_4554045_6 PQQ-like domain K00114 - 1.1.2.8 0.00000000000000000000000000000000000000004047 158.0
SHD2_k127_4554045_7 - - - - 0.00000000000000000000000000000000776 136.0
SHD2_k127_4554045_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.0000000000000000000000000001099 122.0
SHD2_k127_4572915_0 Major Facilitator Superfamily K08177 - - 3.631e-215 677.0
SHD2_k127_4572915_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 606.0
SHD2_k127_4572915_10 Protein of unknown function (DUF1684) K09164 - - 0.000000003487 59.0
SHD2_k127_4572915_11 Major Facilitator Superfamily - - - 0.000005312 50.0
SHD2_k127_4572915_2 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 500.0
SHD2_k127_4572915_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 499.0
SHD2_k127_4572915_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 428.0
SHD2_k127_4572915_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 389.0
SHD2_k127_4572915_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 388.0
SHD2_k127_4572915_7 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000003412 231.0
SHD2_k127_4572915_8 AhpC/TSA family - - - 0.000000000000000000000000000000000000000000000000000000001947 216.0
SHD2_k127_4572915_9 Gram-negative porin - - - 0.000000000000000000000000000000000000003832 162.0
SHD2_k127_4577106_0 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000009865 271.0
SHD2_k127_4577106_1 Microcin C7 resistance K01297 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000816 220.0
SHD2_k127_461011_0 Beta-eliminating lyase K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 501.0
SHD2_k127_461011_1 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 357.0
SHD2_k127_461011_2 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000002625 194.0
SHD2_k127_461011_3 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.0000000000000000000001723 113.0
SHD2_k127_461011_4 Sulfur oxidation protein SoxY K17226 - - 0.00000000000000000001173 107.0
SHD2_k127_461011_5 Sulphur oxidation protein SoxZ K17227 - - 0.00000000000007101 74.0
SHD2_k127_4611707_0 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 520.0
SHD2_k127_4611707_1 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 434.0
SHD2_k127_4613109_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 610.0
SHD2_k127_4613109_1 MMPL family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 503.0
SHD2_k127_4637003_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 638.0
SHD2_k127_4637003_1 Na+ dependent nucleoside transporter C-terminus K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 396.0
SHD2_k127_4637003_2 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 338.0
SHD2_k127_4637003_3 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 302.0
SHD2_k127_4637003_4 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007952 274.0
SHD2_k127_4637003_5 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.0000000000000000000000000000000000000000000000000004926 205.0
SHD2_k127_4637003_6 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000001568 91.0
SHD2_k127_4725119_0 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 422.0
SHD2_k127_4725119_1 Iron-sulphur cluster biosynthesis - - - 0.0000000000000000000000000000000000000000004294 161.0
SHD2_k127_4725119_2 cAMP biosynthetic process - - - 0.00000000000000000000000000000000000000000136 174.0
SHD2_k127_4725119_3 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.0000000000000000000007766 103.0
SHD2_k127_4725119_4 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.0000000000000000004662 103.0
SHD2_k127_4748702_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 4.413e-281 872.0
SHD2_k127_4748702_1 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002441 565.0
SHD2_k127_4748702_2 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 486.0
SHD2_k127_4748702_3 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 342.0
SHD2_k127_4748702_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002057 282.0
SHD2_k127_4748702_5 Rhodanese Homology Domain - - - 0.000000000000000000001146 108.0
SHD2_k127_4748702_6 HEAT repeat - - - 0.00001966 52.0
SHD2_k127_476031_0 pyridoxal-dependent decarboxylase K01580 - 4.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 552.0
SHD2_k127_476031_1 TrkA-C domain K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 533.0
SHD2_k127_476031_2 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 470.0
SHD2_k127_476031_3 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000003235 237.0
SHD2_k127_476031_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000002082 133.0
SHD2_k127_476031_5 Phosphatase K01126,K07093 - 3.1.4.46 0.000000000000000001294 100.0
SHD2_k127_4794363_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.88e-273 868.0
SHD2_k127_4794363_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 4.265e-272 851.0
SHD2_k127_4794363_2 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 520.0
SHD2_k127_4794363_3 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000009922 217.0
SHD2_k127_4794363_4 PFAM BioY protein K03523 - - 0.0000000000000000000000001341 123.0
SHD2_k127_4794363_5 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0000000000309 68.0
SHD2_k127_4874462_0 B12 binding domain K00548 - 2.1.1.13 0.0 1686.0
SHD2_k127_4874462_1 Methylenetetrahydrofolate reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 401.0
SHD2_k127_4874462_10 metal cluster binding K19302 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.1.27 0.0001766 51.0
SHD2_k127_4874462_11 Protein kinase domain K12132 - 2.7.11.1 0.000192 55.0
SHD2_k127_4874462_12 acyl-coa dehydrogenase K00248 - 1.3.8.1 0.0004293 44.0
SHD2_k127_4874462_2 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 366.0
SHD2_k127_4874462_3 Fatty acid desaturase K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000003778 261.0
SHD2_k127_4874462_4 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000221 257.0
SHD2_k127_4874462_5 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000001857 243.0
SHD2_k127_4874462_6 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000006367 181.0
SHD2_k127_4874462_7 YGGT family K02221 - - 0.00000000000000000000000000000000004417 147.0
SHD2_k127_4874462_8 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000001393 141.0
SHD2_k127_4874462_9 Belongs to the UPF0235 family K09131 - - 0.00000000000000000008722 100.0
SHD2_k127_4878015_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 1.92e-266 845.0
SHD2_k127_4878015_1 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 462.0
SHD2_k127_4878015_2 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 409.0
SHD2_k127_4878015_3 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 290.0
SHD2_k127_4878015_4 anaerobic respiration K02568 - - 0.00000000000000000000000000000000000529 150.0
SHD2_k127_4878015_5 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000006279 121.0
SHD2_k127_4912822_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1163.0
SHD2_k127_4912822_1 Elongation factor SelB winged helix 3 K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 404.0
SHD2_k127_4912822_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000002299 98.0
SHD2_k127_4912822_3 protein secretion K21449 - - 0.000000000004917 72.0
SHD2_k127_4912822_4 cobalamin-transporting ATPase activity K02014,K16092 - - 0.00000000002351 68.0
SHD2_k127_4913009_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 556.0
SHD2_k127_4913009_1 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 487.0
SHD2_k127_4913009_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 368.0
SHD2_k127_4913009_3 serine O-acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001578 278.0
SHD2_k127_4913009_4 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000003313 226.0
SHD2_k127_4913009_5 - - - - 0.0000000000000000000000000000000000000000000000000003037 205.0
SHD2_k127_4913009_6 Heat induced stress protein YflT - - - 0.00000000000000000000000002228 126.0
SHD2_k127_4951420_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 504.0
SHD2_k127_4951420_1 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000000000000000000001442 199.0
SHD2_k127_4951420_2 - - - - 0.0000000000000000000000000000000000000009317 158.0
SHD2_k127_4951420_3 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000002134 118.0
SHD2_k127_4951420_4 - - - - 0.000000000000000000000000023 115.0
SHD2_k127_4951420_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102 - 2.7.1.221 0.0000000000000000000004369 111.0
SHD2_k127_4951420_6 - - - - 0.0000000000000000000008835 102.0
SHD2_k127_4951420_7 Protein of unknown function (DUF983) - - - 0.00000000000000000003779 92.0
SHD2_k127_4951420_8 COG1214 Inactive homolog of metal-dependent proteases K01409,K14742 GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000002776 82.0
SHD2_k127_4953802_0 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 608.0
SHD2_k127_4953802_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001046 278.0
SHD2_k127_4953802_2 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000002482 216.0
SHD2_k127_4953802_3 Fibronectin type 3 domain K12685,K16785,K16786,K16787 - - 0.0000000000000000000000000000000000000005829 164.0
SHD2_k127_4953802_4 Psort location Cytoplasmic, score K00945 - 2.7.4.25 0.000000000000000000002254 111.0
SHD2_k127_4953802_5 domain, Protein - - - 0.0000000000001426 83.0
SHD2_k127_4993796_0 TIGRFAM magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase K04034 - 1.21.98.3 1.015e-235 745.0
SHD2_k127_4993796_1 Periplasmic copper-binding protein (NosD) K07218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 369.0
SHD2_k127_4993796_2 ABC-2 family transporter protein K19341 - - 0.00000000000000000000000000000000000000000000000000000000000001008 239.0
SHD2_k127_4993796_3 ABC-type multidrug transport system ATPase component K19340 - - 0.0000000000000000000000000000000000000000000000000000000005458 224.0
SHD2_k127_4993796_4 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.000000000000000000000000000000000000002636 164.0
SHD2_k127_4993796_5 metal-sulfur cluster biosynthetic enzyme - - - 0.000000000000000000005388 108.0
SHD2_k127_4993796_6 Uncharacterized conserved protein (DUF2249) - - - 0.00000000000002199 83.0
SHD2_k127_4993796_7 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.00002898 55.0
SHD2_k127_5029886_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 569.0
SHD2_k127_5029886_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 449.0
SHD2_k127_5029886_2 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 398.0
SHD2_k127_5029886_3 Aldehyde dehydrogenase family K22187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 316.0
SHD2_k127_5029886_4 Homoserine dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 323.0
SHD2_k127_5029886_5 Domain of unknown function (DUF4105) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001328 275.0
SHD2_k127_5029886_6 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000003711 258.0
SHD2_k127_5029886_7 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000001995 222.0
SHD2_k127_5029886_8 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000008357 228.0
SHD2_k127_5029886_9 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000004399 188.0
SHD2_k127_5050558_0 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 2.945e-217 685.0
SHD2_k127_5050558_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 296.0
SHD2_k127_5050558_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000004281 260.0
SHD2_k127_5050558_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000004511 152.0
SHD2_k127_5050558_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000006939 149.0
SHD2_k127_5050558_5 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 0.0000000000000000000143 106.0
SHD2_k127_5050558_6 Peptidase family M23 - - - 0.0006033 49.0
SHD2_k127_5092296_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 9.034e-194 611.0
SHD2_k127_5092296_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008824 467.0
SHD2_k127_5092296_2 HEAT repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 340.0
SHD2_k127_5092296_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006286 298.0
SHD2_k127_5092296_4 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002034 280.0
SHD2_k127_5092296_5 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000436 214.0
SHD2_k127_5092296_6 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.000000000000000000000000000001268 141.0
SHD2_k127_5092296_7 Cache 3/Cache 2 fusion domain - - - 0.0000000000000000000004477 113.0
SHD2_k127_5092296_8 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000002094 97.0
SHD2_k127_5100465_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 3.935e-214 713.0
SHD2_k127_5100465_1 Short chain fatty K02106 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 443.0
SHD2_k127_5100465_10 Lipopolysaccharide-assembly - - - 0.000000000000000000001352 98.0
SHD2_k127_5100465_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 362.0
SHD2_k127_5100465_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003992 281.0
SHD2_k127_5100465_4 Diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001188 250.0
SHD2_k127_5100465_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000008984 203.0
SHD2_k127_5100465_6 Protein of unknown function (DUF1460) - - - 0.0000000000000000000000000000000000000000000000000000002732 205.0
SHD2_k127_5100465_7 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000006689 185.0
SHD2_k127_5100465_8 - - - - 0.000000000000000000000000000000000000000000000001123 184.0
SHD2_k127_5100465_9 Ham1 family K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000005574 176.0
SHD2_k127_5138444_0 PFAM Bile acid sodium symporter K03325 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 543.0
SHD2_k127_5138444_1 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000006926 223.0
SHD2_k127_5138444_2 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.0000000000000000000000000000000000000000000000000000000007028 208.0
SHD2_k127_5138444_3 Endonuclease Exonuclease Phosphatase - - - 0.000000000000000000000000000000000000000000002775 178.0
SHD2_k127_5138444_4 Helix-hairpin-helix motif - - - 0.0000000000000000003284 91.0
SHD2_k127_5138444_5 PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.000000000000005897 76.0
SHD2_k127_5138444_7 Helix-hairpin-helix motif - - - 0.0000000000007889 75.0
SHD2_k127_5138444_8 - - - - 0.0000008183 57.0
SHD2_k127_5327595_0 P2 response regulator binding domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 440.0
SHD2_k127_5327595_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 308.0
SHD2_k127_5327595_2 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000000000000002488 212.0
SHD2_k127_5327595_3 CheC-like family K03410 - - 0.0000000000000000000000000000000000000000000000000000000002383 218.0
SHD2_k127_5327595_4 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000002705 200.0
SHD2_k127_5327595_5 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000000000000000000000000000003066 190.0
SHD2_k127_5327595_6 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000003055 162.0
SHD2_k127_5327595_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000005091 155.0
SHD2_k127_5327595_8 Two component signalling adaptor domain K03408 - - 0.00004571 52.0
SHD2_k127_5357121_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 6.634e-223 732.0
SHD2_k127_5357121_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 397.0
SHD2_k127_5357121_10 - - - - 0.000000000000007397 77.0
SHD2_k127_5357121_2 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 385.0
SHD2_k127_5357121_3 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004998 286.0
SHD2_k127_5357121_4 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000007548 226.0
SHD2_k127_5357121_6 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000001737 116.0
SHD2_k127_5357121_7 hydrolase (HAD superfamily) K01560 - 3.8.1.2 0.00000000000000000007224 93.0
SHD2_k127_5357121_8 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000001095 92.0
SHD2_k127_5357121_9 Zincin-like metallopeptidase - - - 0.000000000000002034 85.0
SHD2_k127_5380716_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.756e-222 702.0
SHD2_k127_5380716_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 3.275e-203 649.0
SHD2_k127_5380716_2 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 426.0
SHD2_k127_5380716_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 374.0
SHD2_k127_5380716_4 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 345.0
SHD2_k127_5380716_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000125 273.0
SHD2_k127_5380716_6 META domain - - - 0.0000000000000000000000000000006355 132.0
SHD2_k127_5380716_7 GMC oxidoreductase K03333 - 1.1.3.6 0.0000000000009922 73.0
SHD2_k127_5439930_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 636.0
SHD2_k127_5439930_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 557.0
SHD2_k127_5439930_11 - - - - 0.00000000000000001956 95.0
SHD2_k127_5439930_15 Protein involved in calmodulin-dependent protein kinase activity and protein amino acid phosphorylation - - - 0.0009476 50.0
SHD2_k127_5439930_2 proline dipeptidase activity K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 437.0
SHD2_k127_5439930_3 Amidohydrolase family K01487 - 3.5.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 416.0
SHD2_k127_5439930_4 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 314.0
SHD2_k127_5439930_5 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 294.0
SHD2_k127_5439930_6 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000001386 185.0
SHD2_k127_5439930_7 - - - - 0.000000000000000000000000000000000000000000004257 173.0
SHD2_k127_5439930_8 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000003902 156.0
SHD2_k127_5439930_9 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000003713 154.0
SHD2_k127_5461682_0 Domain of unknown function (DUF3471) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 473.0
SHD2_k127_5461682_1 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 383.0
SHD2_k127_5461682_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000198 248.0
SHD2_k127_5461682_3 Domain of unknown function (DUF4396) - - - 0.00000000000000000000000000000000000000000000000002064 184.0
SHD2_k127_5461682_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000002101 191.0
SHD2_k127_5461682_5 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000003089 140.0
SHD2_k127_5461682_6 D-aminopeptidase K16203 - - 0.00000000000000000000000000001367 131.0
SHD2_k127_5469892_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 617.0
SHD2_k127_5469892_1 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004616 389.0
SHD2_k127_5469892_2 aminopeptidase - - - 0.000000000000000000000000000000000000754 152.0
SHD2_k127_5469892_3 Matrixin - - - 0.00000000000000000000000002334 119.0
SHD2_k127_5481165_0 Phosphoenolpyruvate carboxylase K01595 - 4.1.1.31 0.0 1045.0
SHD2_k127_5481165_1 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 426.0
SHD2_k127_5481165_2 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 402.0
SHD2_k127_5481165_3 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009769 432.0
SHD2_k127_5481165_4 CoA binding domain K01902,K08692 - 6.2.1.5,6.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 363.0
SHD2_k127_5481165_5 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.0000000000000003299 79.0
SHD2_k127_5547370_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 455.0
SHD2_k127_5547370_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 391.0
SHD2_k127_5547370_2 Protein of unknown function (DUF1194) K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 326.0
SHD2_k127_5547370_3 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002016 299.0
SHD2_k127_5547370_4 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005143 256.0
SHD2_k127_5547370_5 von Willebrand factor type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000026 257.0
SHD2_k127_5547370_6 S4 RNA-binding domain K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000007071 234.0
SHD2_k127_5547370_7 Oxygen tolerance - - - 0.000009046 60.0
SHD2_k127_5568357_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 8.449e-292 912.0
SHD2_k127_5568357_1 Hsp70 protein K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 588.0
SHD2_k127_5568357_10 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000001406 187.0
SHD2_k127_5568357_11 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000229 186.0
SHD2_k127_5568357_12 Cell cycle protein K05837 - - 0.000000000000000000000000000000000000000000001069 189.0
SHD2_k127_5568357_13 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000000000009983 176.0
SHD2_k127_5568357_14 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000000002791 132.0
SHD2_k127_5568357_15 rod shape-determining protein MreD K03571 - - 0.000000000000000000000553 111.0
SHD2_k127_5568357_2 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 571.0
SHD2_k127_5568357_3 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 550.0
SHD2_k127_5568357_4 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 409.0
SHD2_k127_5568357_5 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 343.0
SHD2_k127_5568357_6 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 330.0
SHD2_k127_5568357_7 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000002089 259.0
SHD2_k127_5568357_8 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000004701 254.0
SHD2_k127_5568357_9 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000004911 227.0
SHD2_k127_5586869_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 444.0
SHD2_k127_5586869_1 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 398.0
SHD2_k127_5586869_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 400.0
SHD2_k127_5586869_3 DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000002534 218.0
SHD2_k127_5586869_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000001036 196.0
SHD2_k127_5586869_5 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000001985 194.0
SHD2_k127_5586869_6 Capsule assembly protein Wzi - - - 0.00000000000001672 86.0
SHD2_k127_5646522_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006461 321.0
SHD2_k127_5646522_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000008945 196.0
SHD2_k127_5646522_2 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.00000000000000000000000008969 117.0
SHD2_k127_5646522_3 FAD binding domain K10960,K21401 - 1.3.1.111,1.3.1.83,1.3.99.38 0.0000000000000000000000001796 115.0
SHD2_k127_5646522_4 - - - - 0.00000000000000002015 91.0
SHD2_k127_5646522_5 - - - - 0.00000007699 56.0
SHD2_k127_5646679_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1155.0
SHD2_k127_5646679_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.0000000000000000005491 91.0
SHD2_k127_5670111_0 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 337.0
SHD2_k127_5670111_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000005158 115.0
SHD2_k127_5670111_2 - - - - 0.000000000001005 69.0
SHD2_k127_5729079_0 ABC transporter transmembrane region K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 541.0
SHD2_k127_5729079_1 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 472.0
SHD2_k127_5729079_2 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 297.0
SHD2_k127_5729079_3 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004875 277.0
SHD2_k127_5729079_4 Ferric uptake regulator family K03711 - - 0.00000000000000000000000000000000000000002064 163.0
SHD2_k127_5729079_5 - - - - 0.00000032 61.0
SHD2_k127_5776632_0 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 489.0
SHD2_k127_5776632_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000002241 200.0
SHD2_k127_5776632_2 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000005041 133.0
SHD2_k127_5776632_3 Domain of unknown function (DUF1844) - - - 0.000001092 60.0
SHD2_k127_5798221_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 6.198e-277 879.0
SHD2_k127_5798221_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 552.0
SHD2_k127_5798221_10 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000007168 89.0
SHD2_k127_5798221_2 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 559.0
SHD2_k127_5798221_3 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 507.0
SHD2_k127_5798221_4 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 386.0
SHD2_k127_5798221_5 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003777 383.0
SHD2_k127_5798221_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 284.0
SHD2_k127_5798221_7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000007588 265.0
SHD2_k127_5798221_8 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000001258 220.0
SHD2_k127_5798221_9 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000001188 222.0
SHD2_k127_5865312_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 6.081e-296 924.0
SHD2_k127_5865312_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - 2.703e-200 631.0
SHD2_k127_5865312_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 562.0
SHD2_k127_5865312_3 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002426 353.0
SHD2_k127_5865312_4 - - - - 0.00000000000000000000001664 116.0
SHD2_k127_5877442_0 FeoA - - - 4.53e-281 884.0
SHD2_k127_5877442_1 isomerase activity K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 349.0
SHD2_k127_5877442_2 lipoprotein localization to outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000007573 237.0
SHD2_k127_5877442_3 iron ion homeostasis K03322,K03709,K04758 - - 0.0000000000000000000000000000000000000000000000000000000000000000009369 241.0
SHD2_k127_5877442_4 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.00000000000000000000000000000000000000000000000000000000001493 214.0
SHD2_k127_5877442_5 Putative MetA-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000008591 184.0
SHD2_k127_5877442_6 MacB-like periplasmic core domain K02004 - - 0.0000000000009673 81.0
SHD2_k127_5877796_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 4.08e-286 892.0
SHD2_k127_5877796_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 6.536e-195 621.0
SHD2_k127_5877796_10 Ribonuclease B OB domain K03704 - - 0.000000000000000000000000000002352 123.0
SHD2_k127_5877796_11 HD domain - - - 0.0000000000000000000000000001579 123.0
SHD2_k127_5877796_12 nuclease K00590,K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 2.1.1.113,3.1.31.1 0.000000000000000000000000001256 124.0
SHD2_k127_5877796_13 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000001832 109.0
SHD2_k127_5877796_14 Peptidase family M28 - - - 0.000001509 54.0
SHD2_k127_5877796_2 Peptidase family M3 K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 512.0
SHD2_k127_5877796_3 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 457.0
SHD2_k127_5877796_4 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 342.0
SHD2_k127_5877796_5 nucleotide catabolic process K01081,K11751,K17224 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 362.0
SHD2_k127_5877796_6 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 317.0
SHD2_k127_5877796_7 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001076 302.0
SHD2_k127_5877796_8 Peptidase family M3 K08602 - - 0.0000000000000000000000000000000000000000007361 160.0
SHD2_k127_5877796_9 Diguanylate cyclase with PAS PAC and GAF sensors - - - 0.00000000000000000000000000000000009489 149.0
SHD2_k127_5889464_0 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 568.0
SHD2_k127_5889464_1 Bacterial transglutaminase-like N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 352.0
SHD2_k127_5889464_2 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009881 271.0
SHD2_k127_5889464_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000001846 215.0
SHD2_k127_5889464_4 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000001139 163.0
SHD2_k127_5889464_5 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000003937 138.0
SHD2_k127_5889464_6 Polymer-forming cytoskeletal - - - 0.000000000000000000008051 106.0
SHD2_k127_5889464_7 - - - - 0.00000002013 63.0
SHD2_k127_5889464_8 membrane - - - 0.0000008668 62.0
SHD2_k127_5894477_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004155 534.0
SHD2_k127_5894477_1 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 411.0
SHD2_k127_5894477_10 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000006578 123.0
SHD2_k127_5894477_11 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000007261 114.0
SHD2_k127_5894477_2 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 391.0
SHD2_k127_5894477_3 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 398.0
SHD2_k127_5894477_4 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 379.0
SHD2_k127_5894477_5 Uncharacterized protein family (UPF0051) K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 282.0
SHD2_k127_5894477_6 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000000003134 201.0
SHD2_k127_5894477_7 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000000007566 194.0
SHD2_k127_5894477_8 Belongs to the UPF0403 family - - - 0.0000000000000000000000000000000000000000000004266 171.0
SHD2_k127_5894477_9 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000000000000004046 175.0
SHD2_k127_5941936_0 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 482.0
SHD2_k127_5941936_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 350.0
SHD2_k127_5941936_2 Bacterial membrane protein, YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 320.0
SHD2_k127_5941936_3 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000002156 213.0
SHD2_k127_5941936_4 Lysylphosphatidylglycerol synthase TM region K07027,K20468 - - 0.0000000000000001572 93.0
SHD2_k127_5945067_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005485 352.0
SHD2_k127_5945067_1 seryl-tRNA synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 346.0
SHD2_k127_5945067_2 Domain of unknown function (DUF1839) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001198 270.0
SHD2_k127_5945067_3 membrane protein involved in D-alanine export K19294 - - 0.0000000000000000000000000000000001733 138.0
SHD2_k127_5945067_4 Phosphopantetheine attachment site - - - 0.0000000000000000000002743 99.0
SHD2_k127_5945067_5 beta-mannosidase K01192 - 3.2.1.25 0.0009007 49.0
SHD2_k127_601085_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 474.0
SHD2_k127_601085_1 3-phosphoshikimate 1-carboxyvinyltransferase activity K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009117 351.0
SHD2_k127_601085_2 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000001406 162.0
SHD2_k127_601085_3 Prephenate dehydrogenase K04517 - 1.3.1.12 0.000000000000000000000000000000000001215 151.0
SHD2_k127_601085_4 Prepilin-type N-terminal cleavage methylation domain K02456,K02650 - - 0.000000616 62.0
SHD2_k127_6011825_0 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 341.0
SHD2_k127_6011825_1 Protein of unknown function (DUF2911) - - - 0.0000000000000000000000000000000000000000000000000000000000000009854 232.0
SHD2_k127_6011825_2 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000003532 196.0
SHD2_k127_6011825_3 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000002557 183.0
SHD2_k127_602187_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 1.241e-213 670.0
SHD2_k127_602187_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 529.0
SHD2_k127_602187_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002459 284.0
SHD2_k127_602187_3 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003576 282.0
SHD2_k127_602187_4 Bacillithiol biosynthesis BshC K22136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005605 257.0
SHD2_k127_602187_5 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000001561 222.0
SHD2_k127_602187_6 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000005726 169.0
SHD2_k127_602187_7 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000001969 140.0
SHD2_k127_602187_8 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000003189 127.0
SHD2_k127_602187_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000004677 75.0
SHD2_k127_6025484_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007629 587.0
SHD2_k127_6025484_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008813 535.0
SHD2_k127_6025484_10 Anti-sigma-K factor rskA - - - 0.00000001073 68.0
SHD2_k127_6025484_2 Nucleoside H+ symporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 491.0
SHD2_k127_6025484_3 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 291.0
SHD2_k127_6025484_4 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000003454 226.0
SHD2_k127_6025484_5 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - 0.0000000000000000000000000000000000000000000000000000000001074 212.0
SHD2_k127_6025484_6 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000001325 196.0
SHD2_k127_6025484_7 Thioredoxin-like - - - 0.00000000000000000000000000000000000001347 158.0
SHD2_k127_6025484_8 Gluconate 2-dehydrogenase subunit 3 - - - 0.00000000000000000000000000000000001144 150.0
SHD2_k127_6025484_9 Sigma-70, region 4 K03088 - - 0.00000000000000000000001047 110.0
SHD2_k127_6070771_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1170.0
SHD2_k127_6070771_1 isoleucine patch - - - 0.00000000000000000000000000000000000000000000000000000000006734 213.0
SHD2_k127_6070771_2 peptidyl-tyrosine sulfation - - - 0.000000008991 69.0
SHD2_k127_6087483_0 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 331.0
SHD2_k127_6087483_1 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006467 306.0
SHD2_k127_6087483_10 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00003015 56.0
SHD2_k127_6087483_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000001101 216.0
SHD2_k127_6087483_3 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000000918 214.0
SHD2_k127_6087483_4 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.0000000000000000000000000000000000000000000000132 191.0
SHD2_k127_6087483_5 TonB C terminal K03832 - - 0.000000000000000000000000000000000000002844 160.0
SHD2_k127_6087483_6 OmpA family K03640 - - 0.00000000000000000000000000000000000003617 150.0
SHD2_k127_6087483_7 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000000000000000007861 137.0
SHD2_k127_6087483_8 LysM domain - - - 0.000000000000000007695 96.0
SHD2_k127_6087483_9 Predicted membrane protein (DUF2243) - - - 0.00000000005847 67.0
SHD2_k127_6141271_0 PFAM Alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 606.0
SHD2_k127_6141271_1 Hsp70 protein K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008241 400.0
SHD2_k127_6141271_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 321.0
SHD2_k127_6147492_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 1.66e-196 625.0
SHD2_k127_6147492_1 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 572.0
SHD2_k127_6147492_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 567.0
SHD2_k127_6147492_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001708 278.0
SHD2_k127_6147492_4 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000002398 264.0
SHD2_k127_6147492_5 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000005947 74.0
SHD2_k127_6159193_0 TonB dependent receptor K16089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 479.0
SHD2_k127_6159193_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004921 257.0
SHD2_k127_6159193_2 HmuY protein - - - 0.0000000000000000000000000000000000000000000000000001329 200.0
SHD2_k127_6159193_3 Prolyl oligopeptidase family K06889 - - 0.000000000000000000000000000000000000000000000006101 185.0
SHD2_k127_6159193_4 NUDIX domain - - - 0.0000000000000000000000000000009971 130.0
SHD2_k127_6159193_5 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000001756 72.0
SHD2_k127_6205400_0 Aminotransferase class-V - - - 1.029e-195 629.0
SHD2_k127_6205400_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 364.0
SHD2_k127_6205400_2 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 338.0
SHD2_k127_6205400_3 metal-dependent phosphohydrolase, HD sub domain K03698 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001781 259.0
SHD2_k127_6205400_4 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000003034 199.0
SHD2_k127_6205400_5 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000002579 171.0
SHD2_k127_6205400_6 MerR HTH family regulatory protein - - - 0.00000000000000000000000000007066 130.0
SHD2_k127_6205400_7 Cold shock protein K03704 - - 0.0000000000000000000000000001575 117.0
SHD2_k127_6205400_8 - - - - 0.0000000000000000000000001271 115.0
SHD2_k127_6205400_9 acetoacetate metabolism regulatory protein AtoC K07714 K07713 - - 0.00008898 53.0
SHD2_k127_6285007_0 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 495.0
SHD2_k127_6285007_1 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 481.0
SHD2_k127_6285007_2 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007212 441.0
SHD2_k127_6285007_3 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007336 395.0
SHD2_k127_6285007_4 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 385.0
SHD2_k127_6285007_5 COG3911 Predicted ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000002884 232.0
SHD2_k127_6285007_6 phosphorelay signal transduction system K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000006219 189.0
SHD2_k127_6285007_7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01479,K12255 - 3.5.3.7,3.5.3.8 0.0000000000000000000000000000000000000005091 169.0
SHD2_k127_63283_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 593.0
SHD2_k127_63283_1 Biotin carboxylase C-terminal domain K01941,K01961 - 6.3.4.14,6.3.4.6,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 481.0
SHD2_k127_63283_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004823 439.0
SHD2_k127_63283_3 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002204 254.0
SHD2_k127_63283_4 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000009381 224.0
SHD2_k127_63283_5 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.00000000000000000000000000000000000000005487 162.0
SHD2_k127_6359934_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 5.819e-224 715.0
SHD2_k127_6359934_1 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005492 338.0
SHD2_k127_6417489_0 phosphoribosylamine-glycine ligase activity K01945,K01955 - 6.3.4.13,6.3.5.5 8.115e-198 624.0
SHD2_k127_6417489_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 382.0
SHD2_k127_6417489_2 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000706 268.0
SHD2_k127_6419103_0 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 477.0
SHD2_k127_6419103_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000002595 98.0
SHD2_k127_6419103_2 - - - - 0.0000000000001017 81.0
SHD2_k127_6485342_0 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 5.328e-216 684.0
SHD2_k127_6485342_1 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000006399 198.0
SHD2_k127_6485342_2 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000000000534 218.0
SHD2_k127_6485342_3 bis(5'-adenosyl)-triphosphatase activity - - - 0.00000000000000000000000000000000000000000000000000005952 196.0
SHD2_k127_6485342_4 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000001115 194.0
SHD2_k127_6485342_5 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000006732 61.0
SHD2_k127_6516450_0 PFAM Tetratricopeptide - - - 7.823e-273 886.0
SHD2_k127_6516450_1 Electron transfer flavoprotein domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 305.0
SHD2_k127_6516450_2 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003839 275.0
SHD2_k127_6516450_3 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000003628 231.0
SHD2_k127_6562187_0 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 402.0
SHD2_k127_6562187_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000614 397.0
SHD2_k127_6562187_2 PFAM FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000003566 177.0
SHD2_k127_6562187_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000001609 64.0
SHD2_k127_6599402_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 383.0
SHD2_k127_6599402_1 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 310.0
SHD2_k127_6599402_3 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000002423 125.0
SHD2_k127_6612749_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 451.0
SHD2_k127_6612749_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006337 471.0
SHD2_k127_6612749_2 Belongs to the peptidase S51 family K05995 - 3.4.13.21 0.000000000000000000000000000000000000000000000000000000000000000000004771 256.0
SHD2_k127_6612749_3 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000001338 217.0
SHD2_k127_6612749_4 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000007071 201.0
SHD2_k127_6612749_5 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000004397 141.0
SHD2_k127_6612749_6 - - - - 0.000000000009607 72.0
SHD2_k127_6615467_0 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 612.0
SHD2_k127_6615467_1 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005669 442.0
SHD2_k127_6615467_2 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 391.0
SHD2_k127_6615467_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 312.0
SHD2_k127_6615467_4 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 338.0
SHD2_k127_6615467_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 295.0
SHD2_k127_6615467_6 COGs COG3752 membrane protein - - - 0.00000000000000000000000000000000000000000000000008171 186.0
SHD2_k127_6615467_7 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000004049 149.0
SHD2_k127_6615467_8 Amino-transferase class IV K02619,K03342 - 2.6.1.85,4.1.3.38 0.000000000001789 80.0
SHD2_k127_6619313_0 Circularly permuted ATP-grasp type 2 - - - 1.318e-200 637.0
SHD2_k127_6619313_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 400.0
SHD2_k127_6619313_2 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000001694 261.0
SHD2_k127_6619313_3 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000002479 113.0
SHD2_k127_6619313_4 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000001401 74.0
SHD2_k127_6619313_5 transglutaminase - - - 0.000005778 50.0
SHD2_k127_6653631_0 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0 1519.0
SHD2_k127_6653631_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 332.0
SHD2_k127_6674496_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1659.0
SHD2_k127_6674496_1 B12 binding domain K01847 - 5.4.99.2 0.0 1041.0
SHD2_k127_6674496_10 Outer membrane protein beta-barrel domain - - - 0.0000001339 60.0
SHD2_k127_6674496_2 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 597.0
SHD2_k127_6674496_3 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 353.0
SHD2_k127_6674496_4 DNA helicase K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 317.0
SHD2_k127_6674496_5 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003 260.0
SHD2_k127_6674496_6 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000001229 243.0
SHD2_k127_6674496_7 enoyl-CoA hydratase isomerase family K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000003853 200.0
SHD2_k127_6674496_8 Subtilase family - - - 0.000000000000000007162 98.0
SHD2_k127_6674496_9 Outer membrane protein beta-barrel domain - - - 0.00000009345 64.0
SHD2_k127_6698457_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 521.0
SHD2_k127_6698457_1 cobalamin-transporting ATPase activity K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 366.0
SHD2_k127_6698457_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000004165 255.0
SHD2_k127_6698457_3 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000007515 229.0
SHD2_k127_6698457_4 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000004965 168.0
SHD2_k127_6698457_5 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000001547 171.0
SHD2_k127_6698457_6 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000002917 167.0
SHD2_k127_6698457_7 Cytochrome c - - - 0.00000000000000000004668 104.0
SHD2_k127_6719645_0 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 576.0
SHD2_k127_6719645_1 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 422.0
SHD2_k127_6719645_2 ApaG domain K06195 - - 0.00000000000000000000000000000000000000000000000000000000001138 208.0
SHD2_k127_6719645_3 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000003953 204.0
SHD2_k127_6739186_0 CobN magnesium chelatase K03403 - 6.6.1.1 0.0 1455.0
SHD2_k127_6739186_1 Major facilitator superfamily K08226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 518.0
SHD2_k127_6739186_10 photosynthetic reaction center H subunit K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.00000000002712 76.0
SHD2_k127_6739186_2 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP K04037 - 1.3.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 470.0
SHD2_k127_6739186_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K04035 - 1.14.13.81,1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 473.0
SHD2_k127_6739186_4 Magnesium-protoporphyrin IX methyltransferase C-terminus K03428 - 2.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004501 297.0
SHD2_k127_6739186_5 photosynthetic reaction center H subunit K13991 - - 0.00000000000000000000000000000000000000000000000282 181.0
SHD2_k127_6739186_6 Bacterial PH domain - - - 0.000000000000000000000000000000000000002365 162.0
SHD2_k127_6739186_8 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex K04039 - 1.3.7.7 0.000000000000000000003927 96.0
SHD2_k127_6739186_9 Photosynthetic complex assembly protein - - - 0.00000000000000000002017 104.0
SHD2_k127_6810869_0 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 583.0
SHD2_k127_6810869_1 chelatase, subunit ChlI K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 321.0
SHD2_k127_6810869_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 302.0
SHD2_k127_6810869_3 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005215 264.0
SHD2_k127_6810869_4 RF-1 domain K15034 - - 0.000000000000000000000000000000000149 137.0
SHD2_k127_6810869_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000001637 91.0
SHD2_k127_6871814_0 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 595.0
SHD2_k127_6871814_1 TIGRFAM HAD-superfamily subfamily IIA hydrolase like protein - - - 0.000000000000000000000000000000000000000000000002701 183.0
SHD2_k127_6871814_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000001566 191.0
SHD2_k127_6871814_3 Rad51 - - - 0.00000000000000000000000000000000000199 146.0
SHD2_k127_6871814_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000002863 149.0
SHD2_k127_6871814_5 - - - - 0.000000000000000000000000000000000006184 143.0
SHD2_k127_6871814_6 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000007447 115.0
SHD2_k127_6882717_0 Major facilitator K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 439.0
SHD2_k127_6882717_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 431.0
SHD2_k127_6882717_10 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.000000000000000002598 98.0
SHD2_k127_6882717_11 - - - - 0.0000000000001117 84.0
SHD2_k127_6882717_12 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000002945 66.0
SHD2_k127_6882717_2 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 363.0
SHD2_k127_6882717_3 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 341.0
SHD2_k127_6882717_4 PFAM Integral membrane protein TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 326.0
SHD2_k127_6882717_5 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 338.0
SHD2_k127_6882717_6 PFAM peptidase K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 294.0
SHD2_k127_6882717_7 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000006117 166.0
SHD2_k127_6882717_8 coa-binding K06929 - - 0.0000000000000000000000000000002043 129.0
SHD2_k127_6882717_9 TIGRFAM 6-pyruvoyl tetrahydropterin synthase QueD family protein K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000002448 96.0
SHD2_k127_7013530_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 6.867e-255 801.0
SHD2_k127_7013530_1 Insulinase (Peptidase family M16) K07263 - - 1.001e-210 684.0
SHD2_k127_7013530_10 OsmC-like protein K07397 - - 0.0000000000000000000000001087 111.0
SHD2_k127_7013530_11 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000002338 106.0
SHD2_k127_7013530_12 - - - - 0.000000000000000000831 90.0
SHD2_k127_7013530_14 Outer membrane efflux protein K12340 - - 0.000000418 63.0
SHD2_k127_7013530_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 2.019e-195 624.0
SHD2_k127_7013530_3 Sugar (and other) transporter K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 584.0
SHD2_k127_7013530_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 438.0
SHD2_k127_7013530_5 Biotin-lipoyl like K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003506 293.0
SHD2_k127_7013530_6 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000309 178.0
SHD2_k127_7013530_7 Bacterial transcriptional repressor C-terminal K09017 - - 0.00000000000000000000000000000001218 135.0
SHD2_k127_7013530_8 Histidine kinase K01768,K02482,K02660,K03406,K05874,K07315,K10819,K11525,K11617 - 2.7.13.3,3.1.3.3,4.6.1.1 0.0000000000000000000000000006358 123.0
SHD2_k127_7013530_9 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000002194 121.0
SHD2_k127_7017001_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 557.0
SHD2_k127_7017001_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 377.0
SHD2_k127_7017001_10 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000277 132.0
SHD2_k127_7017001_11 PFAM Sulfate transporter antisigma-factor antagonist STAS - - - 0.000737 48.0
SHD2_k127_7017001_2 Glucose inhibited division protein A K21401 - 1.3.99.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 296.0
SHD2_k127_7017001_3 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000006864 239.0
SHD2_k127_7017001_4 water channel activity K02440,K06188,K09874 - - 0.0000000000000000000000000000000000000000000000000000000000005257 218.0
SHD2_k127_7017001_5 CcmB protein K02194 - - 0.0000000000000000000000000000000000000000000000000000000002011 211.0
SHD2_k127_7017001_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000006274 181.0
SHD2_k127_7017001_7 ABC transporter K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000007675 183.0
SHD2_k127_7017001_8 Flavin reductase like domain - - - 0.0000000000000000000000000000000000001028 160.0
SHD2_k127_7017001_9 Methyltransferase domain - - - 0.00000000000000000000000000000000001226 144.0
SHD2_k127_7039057_0 lysine biosynthetic process via aminoadipic acid - - - 4.666e-236 759.0
SHD2_k127_7039057_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008426 405.0
SHD2_k127_7039057_2 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000001389 205.0
SHD2_k127_7161252_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.931e-227 760.0
SHD2_k127_7161252_1 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 321.0
SHD2_k127_7161252_2 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000001357 271.0
SHD2_k127_7161252_3 PPIC-type PPIASE domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000002072 236.0
SHD2_k127_7161252_4 bacterial-type flagellum-dependent cell motility K01317 - 3.4.21.10 0.000000000000000000000000000000000000000184 167.0
SHD2_k127_7161252_5 - - - - 0.00000000000000000009646 90.0
SHD2_k127_7182880_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 554.0
SHD2_k127_7182880_1 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 521.0
SHD2_k127_7182880_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000004014 156.0
SHD2_k127_7182880_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000001356 75.0
SHD2_k127_7257851_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 517.0
SHD2_k127_7257851_1 Aldehyde dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 455.0
SHD2_k127_7257851_2 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 353.0
SHD2_k127_7257851_3 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006835 274.0
SHD2_k127_7257851_4 PFAM Uncharacterised protein family (UPF0093) K08973 - - 0.00000000000000000000000000000000000000000000000001389 186.0
SHD2_k127_7257851_5 4-vinyl reductase, 4VR K04036 GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000007251 163.0
SHD2_k127_7257851_6 AI-2E family transporter - - - 0.0000000000000001256 80.0
SHD2_k127_7257851_7 deoxyhypusine monooxygenase activity - - - 0.0005325 51.0
SHD2_k127_7259216_0 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 5.914e-289 911.0
SHD2_k127_7259216_1 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000000004977 211.0
SHD2_k127_7259216_2 glyoxalase bleomycin resistance protein dioxygenase K07032 - - 0.000000000000000000000000000000000000000000000002889 177.0
SHD2_k127_7259216_3 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000221 175.0
SHD2_k127_7259216_4 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000000000001156 156.0
SHD2_k127_7276991_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.982e-218 702.0
SHD2_k127_7276991_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 487.0
SHD2_k127_7276991_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 441.0
SHD2_k127_7276991_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001797 267.0
SHD2_k127_7276991_4 Nucleotidyl transferase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000003117 195.0
SHD2_k127_7276991_5 - - - - 0.00000000002057 75.0
SHD2_k127_7276991_6 distant relative of homeotic protein bithoraxoid K07131 - - 0.00000331 54.0
SHD2_k127_7276991_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.3.5.6,6.3.5.7 0.0002156 55.0
SHD2_k127_7301557_0 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000002549 267.0
SHD2_k127_7301557_1 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000001139 207.0
SHD2_k127_7301557_2 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000001982 203.0
SHD2_k127_7301557_3 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000004293 148.0
SHD2_k127_7301557_4 Phosphoesterase K07098 - - 0.0000000000000001138 90.0
SHD2_k127_7311908_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 529.0
SHD2_k127_7311908_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 544.0
SHD2_k127_7311908_10 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000003007 156.0
SHD2_k127_7311908_11 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000002867 99.0
SHD2_k127_7311908_12 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.0000000000000000006343 87.0
SHD2_k127_7311908_13 TonB-dependent Receptor Plug Domain - - - 0.0000008508 62.0
SHD2_k127_7311908_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 447.0
SHD2_k127_7311908_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 404.0
SHD2_k127_7311908_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000001618 238.0
SHD2_k127_7311908_5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000000000000000005362 220.0
SHD2_k127_7311908_6 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000004907 220.0
SHD2_k127_7311908_7 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000001006 229.0
SHD2_k127_7311908_8 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000006009 203.0
SHD2_k127_7311908_9 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000001015 166.0
SHD2_k127_7328731_0 amine dehydrogenase activity K17285 - - 5.969e-246 765.0
SHD2_k127_7328731_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 515.0
SHD2_k127_7328731_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 286.0
SHD2_k127_7328731_3 COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog - - - 0.000000000000000000000000000000000000000000000000000101 193.0
SHD2_k127_7328731_4 - - - - 0.000000000000000000000000000000000000000000000002982 195.0
SHD2_k127_7328731_5 Domain of unknown function (DUF3943) - - - 0.00000000000000000000000000000000000000000006837 173.0
SHD2_k127_7356662_0 PFAM Prolyl oligopeptidase family - - - 3.022e-202 655.0
SHD2_k127_7356662_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007307 378.0
SHD2_k127_7356662_2 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007382 317.0
SHD2_k127_7356662_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002956 267.0
SHD2_k127_7356662_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000001925 151.0
SHD2_k127_7356662_5 Protein of unknown function (DUF983) - - - 0.000000000000000000000008344 106.0
SHD2_k127_7356662_6 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0003328 44.0
SHD2_k127_7356662_7 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0003485 46.0
SHD2_k127_7382734_0 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 329.0
SHD2_k127_7382734_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 300.0
SHD2_k127_7382734_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001387 287.0
SHD2_k127_7382734_3 PFAM SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007117 272.0
SHD2_k127_7382734_4 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000000000000000000000007933 220.0
SHD2_k127_7382734_5 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.000000000000000000000000000000000000000000000000000000213 203.0
SHD2_k127_7382734_6 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000001871 157.0
SHD2_k127_7382734_7 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000001497 155.0
SHD2_k127_7382734_8 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000004457 89.0
SHD2_k127_7382734_9 maturation - - - 0.00000000000007142 76.0
SHD2_k127_7400028_0 Belongs to the DEAD box helicase family K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 7.155e-199 643.0
SHD2_k127_7400028_1 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000004694 265.0
SHD2_k127_7400028_2 acetyltransferase - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 - 0.000000000000000000000000000000000000000000000000000000000000002622 224.0
SHD2_k127_7400028_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000002121 188.0
SHD2_k127_7400028_4 Tetratricopeptide repeat - - - 0.0006968 44.0
SHD2_k127_7413478_0 HELICc2 K03722 - 3.6.4.12 1.461e-266 846.0
SHD2_k127_7413478_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 484.0
SHD2_k127_7413478_2 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 464.0
SHD2_k127_7413478_3 Domain of unknown function (DUF2437) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001486 265.0
SHD2_k127_7413478_4 - - - - 0.0000000000000000000000000000102 126.0
SHD2_k127_7425630_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 6.873e-232 737.0
SHD2_k127_7425630_1 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000996 424.0
SHD2_k127_7425630_10 COG4635 Flavodoxin K00230 - 1.3.5.3 0.00000000000000000000000000009509 124.0
SHD2_k127_7425630_11 Transglycosylase associated protein - - - 0.00000000000000000000000002016 113.0
SHD2_k127_7425630_12 - - - - 0.000000000000001066 78.0
SHD2_k127_7425630_13 Periplasmic or secreted lipoprotein - - - 0.000000000118 74.0
SHD2_k127_7425630_14 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000004888 68.0
SHD2_k127_7425630_2 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002206 282.0
SHD2_k127_7425630_3 Glycosyl hydrolase family 20, catalytic domain K12373 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000002391 278.0
SHD2_k127_7425630_4 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003053 261.0
SHD2_k127_7425630_5 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004953 255.0
SHD2_k127_7425630_6 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005133 277.0
SHD2_k127_7425630_7 PFAM Glycosyl transferase, group 1 K08256 - 2.4.1.345 0.0000000000000000000000000000000000000000000000000000000000000000000008699 250.0
SHD2_k127_7425630_8 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000004563 215.0
SHD2_k127_7425630_9 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000001136 160.0
SHD2_k127_7429526_0 LVIVD repeat - - - 1.651e-225 703.0
SHD2_k127_7429526_1 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 367.0
SHD2_k127_7429526_2 ATPases associated with a variety of cellular activities K05833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003754 301.0
SHD2_k127_7429526_3 Belongs to the binding-protein-dependent transport system permease family K05832 - - 0.000000000000000000000000000000000000000000000000000000000000007806 232.0
SHD2_k127_7429526_4 antisigma factor binding K04749 - - 0.0000000000000000000000000000000000000000000000005387 192.0
SHD2_k127_7429526_5 transport system periplasmic component K01989 - - 0.0000000000000000000000000000005835 135.0
SHD2_k127_7437266_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 501.0
SHD2_k127_7437266_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012,K16180 - 2.8.1.6,5.4.99.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 399.0
SHD2_k127_7437266_2 Site-specific recombinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 419.0
SHD2_k127_7437266_3 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.000000000000000000000000000000393 141.0
SHD2_k127_7437266_5 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.0000000000000000000005784 103.0
SHD2_k127_7451683_0 PFAM DAHP synthetase I KDSA K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 456.0
SHD2_k127_7451683_1 Transcriptional regulator K09017 - - 0.00000000000000000000000000000000000000000007003 168.0
SHD2_k127_7451683_2 PDZ domain - - - 0.0000000184 60.0
SHD2_k127_7514590_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000006188 241.0
SHD2_k127_7514590_1 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002123 236.0
SHD2_k127_7514590_2 Protein of unknown function (DUF2892) - - - 0.0000000005207 62.0
SHD2_k127_7514590_3 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.00007535 56.0
SHD2_k127_754451_0 NapC/NirT cytochrome c family, N-terminal region - - - 0.000000000000000000000000000000000000000007662 173.0
SHD2_k127_754451_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000000000000000004018 128.0
SHD2_k127_7553744_0 Protein export membrane protein - - - 0.0 1413.0
SHD2_k127_7553744_1 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 302.0
SHD2_k127_7553744_2 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000008748 208.0
SHD2_k127_7565942_0 Thiolase, C-terminal domain K00626,K07508 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009105 445.0
SHD2_k127_7565942_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 321.0
SHD2_k127_7565942_2 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005083 298.0
SHD2_k127_7565942_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000008357 226.0
SHD2_k127_7565942_4 - - - - 0.00000000000000000000002946 110.0
SHD2_k127_7565942_5 FAD binding domain K10960,K21401 - 1.3.1.111,1.3.1.83,1.3.99.38 0.0000000007917 63.0
SHD2_k127_75959_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1549.0
SHD2_k127_75959_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 494.0
SHD2_k127_75959_10 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000006024 189.0
SHD2_k127_75959_11 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000002128 153.0
SHD2_k127_75959_12 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000001024 93.0
SHD2_k127_75959_13 Ribosomal protein L36 K02919 - - 0.00000000001201 74.0
SHD2_k127_75959_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 440.0
SHD2_k127_75959_3 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007316 307.0
SHD2_k127_75959_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 283.0
SHD2_k127_75959_5 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000009507 245.0
SHD2_k127_75959_6 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000000000111 204.0
SHD2_k127_75959_7 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000001098 198.0
SHD2_k127_75959_8 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000006191 191.0
SHD2_k127_75959_9 RmlD substrate binding domain K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000000000000006866 209.0
SHD2_k127_7661453_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 4.466e-302 936.0
SHD2_k127_7661453_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.598e-233 732.0
SHD2_k127_7661453_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 517.0
SHD2_k127_7661453_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000381 280.0
SHD2_k127_7661453_4 PFAM Mo-dependent nitrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005958 265.0
SHD2_k127_7661453_5 - - - - 0.000000000000000000000000000000000001064 147.0
SHD2_k127_773266_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.288e-273 849.0
SHD2_k127_773266_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000006113 218.0
SHD2_k127_773266_2 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.000000000000000000000000000000000003834 149.0
SHD2_k127_773266_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000004245 139.0
SHD2_k127_773266_4 NlpC/P60 family - - - 0.00000000000000000000007481 111.0
SHD2_k127_773266_5 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000007374 64.0
SHD2_k127_773335_0 Type III secretion system lipoprotein chaperone (YscW) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 365.0
SHD2_k127_773335_1 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000000000001405 169.0
SHD2_k127_773335_2 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000004534 150.0
SHD2_k127_773335_3 ferredoxin - - - 0.000000000000000000000000000000000005656 147.0
SHD2_k127_773335_4 RES - - - 0.00000000000000000000000000000000114 138.0
SHD2_k127_773335_5 Protein of unknown function (DUF2892) - - - 0.000000000000000000000000003709 111.0
SHD2_k127_773335_6 Protein of unknown function (DUF2384) - - - 0.00000000000000005332 86.0
SHD2_k127_773335_7 Protein export membrane protein - - - 0.000005754 49.0
SHD2_k127_773335_8 Belongs to the peptidase S8 family - - - 0.0003029 53.0
SHD2_k127_7767396_0 PFAM peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 452.0
SHD2_k127_7767396_1 PAS fold K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009893 419.0
SHD2_k127_7767396_2 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000006401 260.0
SHD2_k127_7767396_3 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000002008 226.0
SHD2_k127_7821799_0 DNA polymerase beta thumb K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 557.0
SHD2_k127_7821799_1 PFAM aminotransferase, class I K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 436.0
SHD2_k127_7821799_2 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009121 381.0
SHD2_k127_7821799_3 ABC transporter substrate binding protein K01989,K05832 - - 0.000000000000000000000000000000000000000000000000000000000000000001089 251.0
SHD2_k127_7821799_4 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000008905 216.0
SHD2_k127_7821799_5 - - - - 0.000000000000000000000478 111.0
SHD2_k127_7821799_6 PFAM ABC transporter related K05833 - - 0.0000000000001252 82.0
SHD2_k127_7896703_0 RNA polymerase sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006895 569.0
SHD2_k127_7896703_1 Mo-co oxidoreductase dimerisation domain K17225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 419.0
SHD2_k127_7896703_2 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001718 287.0
SHD2_k127_7896703_3 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000006208 201.0
SHD2_k127_7896703_4 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000009509 189.0
SHD2_k127_7896703_5 Cytochrome C oxidase, cbb3-type, subunit III K08738 - - 0.000000000000000000000000000000000000000000000000004118 199.0
SHD2_k127_7896703_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000005642 164.0
SHD2_k127_7896703_7 - K07112 - - 0.00000000000000000000000000000000000000004346 160.0
SHD2_k127_7921435_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 427.0
SHD2_k127_7921435_1 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 400.0
SHD2_k127_7921435_2 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 363.0
SHD2_k127_7921435_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000003455 232.0
SHD2_k127_7921435_4 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000001836 203.0
SHD2_k127_7921435_5 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000000002502 131.0
SHD2_k127_7921435_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000001532 131.0
SHD2_k127_7921435_7 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000984 111.0
SHD2_k127_7921435_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000001334 73.0
SHD2_k127_7921435_9 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00001145 50.0
SHD2_k127_7972059_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 444.0
SHD2_k127_7972059_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 411.0
SHD2_k127_7972059_2 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 342.0
SHD2_k127_7972059_3 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001302 298.0
SHD2_k127_7972059_4 extracellular polysaccharide biosynthetic process K13582 - - 0.0000000000000000000000000000000000000000000000000000000001458 217.0
SHD2_k127_7972059_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000674 137.0
SHD2_k127_7988755_0 Ftsk_gamma K03466 - - 1.135e-203 664.0
SHD2_k127_7988755_1 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 596.0
SHD2_k127_7988755_10 Modulates RecA activity K03565 - - 0.0000000000000000000000421 107.0
SHD2_k127_7988755_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 544.0
SHD2_k127_7988755_3 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 507.0
SHD2_k127_7988755_4 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 428.0
SHD2_k127_7988755_5 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 333.0
SHD2_k127_7988755_6 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000002771 190.0
SHD2_k127_7988755_7 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.0000000000000000000000000000000000000000000226 175.0
SHD2_k127_7988755_8 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000001875 144.0
SHD2_k127_7988755_9 Uncharacterised protein family UPF0102 K07460 - - 0.0000000000000000000000001152 111.0
SHD2_k127_8023675_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 548.0
SHD2_k127_8023675_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 346.0
SHD2_k127_8023675_2 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 347.0
SHD2_k127_8023860_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 520.0
SHD2_k127_8023860_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008824 458.0
SHD2_k127_8023860_10 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000001804 190.0
SHD2_k127_8023860_11 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000009026 199.0
SHD2_k127_8023860_12 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000005343 184.0
SHD2_k127_8023860_13 EXOIII K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000005021 194.0
SHD2_k127_8023860_14 Met-10+ like-protein K02687 - - 0.00000000000000000000000000000000000000003594 162.0
SHD2_k127_8023860_15 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000002365 156.0
SHD2_k127_8023860_16 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000916 150.0
SHD2_k127_8023860_17 HIT domain K02503 - - 0.00000000000000000000000000000000000000664 150.0
SHD2_k127_8023860_18 STAS domain K04749 - - 0.00000000000000000000000000000001041 130.0
SHD2_k127_8023860_19 Ribosomal protein S21 K02970 - - 0.000000000000000000000002197 103.0
SHD2_k127_8023860_2 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 467.0
SHD2_k127_8023860_20 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000003642 109.0
SHD2_k127_8023860_21 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.000000000000000002045 95.0
SHD2_k127_8023860_22 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.00000000000000007447 89.0
SHD2_k127_8023860_23 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000004271 81.0
SHD2_k127_8023860_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 439.0
SHD2_k127_8023860_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 355.0
SHD2_k127_8023860_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006263 311.0
SHD2_k127_8023860_6 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000006138 267.0
SHD2_k127_8023860_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008416 251.0
SHD2_k127_8023860_8 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000000000000000003482 240.0
SHD2_k127_8023860_9 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000002076 238.0
SHD2_k127_8052846_0 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006545 544.0
SHD2_k127_8052846_1 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 477.0
SHD2_k127_8052846_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000003285 233.0
SHD2_k127_8052846_3 - - - - 0.0000000000000000000000002027 124.0
SHD2_k127_8052846_4 methyltransferase activity - - - 0.00000000002567 70.0
SHD2_k127_8058833_0 von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 601.0
SHD2_k127_8058833_1 Threonine/Serine exporter, ThrE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 329.0
SHD2_k127_8058833_2 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000003381 172.0
SHD2_k127_8274854_0 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 398.0
SHD2_k127_8274854_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 322.0
SHD2_k127_8274854_2 CDGSH-type zinc finger. Function unknown. - - - 0.000000000000000000000000000000000000000000000000000000001532 208.0
SHD2_k127_8274854_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000001018 169.0
SHD2_k127_8303337_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1163.0
SHD2_k127_8303337_1 alginic acid biosynthetic process - - - 6.443e-228 734.0
SHD2_k127_8303337_10 Thioredoxin - - - 0.000000000000000000000000000000133 141.0
SHD2_k127_8303337_11 Haem-degrading K11477 - - 0.0000000000000000000000000000001812 129.0
SHD2_k127_8303337_12 - - - - 0.000000000000000000000000000686 130.0
SHD2_k127_8303337_13 Aminotransferase class-V - - - 0.00000000000000000000000002472 121.0
SHD2_k127_8303337_14 Transcriptional regulator K22106 - - 0.00000000000003315 80.0
SHD2_k127_8303337_15 lipolytic protein G-D-S-L family - - - 0.000001546 59.0
SHD2_k127_8303337_16 Tricorn protease homolog - - - 0.00005279 54.0
SHD2_k127_8303337_17 Calcineurin-like phosphoesterase - - - 0.0007227 53.0
SHD2_k127_8303337_2 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 452.0
SHD2_k127_8303337_3 polyphosphate kinase activity K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 407.0
SHD2_k127_8303337_4 Asparaginase K01444 - 3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 380.0
SHD2_k127_8303337_5 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 328.0
SHD2_k127_8303337_6 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000862 245.0
SHD2_k127_8303337_7 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000001244 201.0
SHD2_k127_8303337_8 - - - - 0.000000000000000000000000000000000000000115 171.0
SHD2_k127_8303337_9 Fe-S metabolism associated domain K02426 - - 0.00000000000000000000000000000006931 136.0
SHD2_k127_8315629_0 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 360.0
SHD2_k127_8315629_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000009701 88.0
SHD2_k127_8315629_2 peptidyl-tyrosine sulfation - - - 0.00000000000001947 89.0
SHD2_k127_8317878_0 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 374.0
SHD2_k127_8317878_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001063 251.0
SHD2_k127_8317878_2 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000000000000000000000004283 217.0
SHD2_k127_8317878_3 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000002351 157.0
SHD2_k127_8317878_4 Iron-sulfur cluster assembly protein - - - 0.00000000000000000000000000001591 127.0
SHD2_k127_8317878_5 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000764 107.0
SHD2_k127_8317878_6 Thioesterase K07107,K12500 - - 0.00000000000000000009068 102.0
SHD2_k127_8317878_7 Peptidase, M28 - - - 0.00000008168 64.0
SHD2_k127_8353548_0 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 408.0
SHD2_k127_8353548_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 346.0
SHD2_k127_8353548_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 325.0
SHD2_k127_8353548_3 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000000000000000000006773 232.0
SHD2_k127_8353548_4 Bacterial regulatory proteins, tetR family K09017 - - 0.000000000001239 75.0
SHD2_k127_841594_0 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004672 322.0
SHD2_k127_841594_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 305.0
SHD2_k127_841594_2 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000003463 207.0
SHD2_k127_841594_3 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000003603 160.0
SHD2_k127_841594_4 Protein of unknown function (DUF2892) - - - 0.000000001412 64.0
SHD2_k127_919161_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.845e-249 802.0
SHD2_k127_919161_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008881 484.0
SHD2_k127_919161_10 histidine kinase HAMP region domain protein K03406,K05874,K05875 - - 0.0000000006486 70.0
SHD2_k127_919161_2 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 406.0
SHD2_k127_919161_3 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 324.0
SHD2_k127_919161_4 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004352 248.0
SHD2_k127_919161_5 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000003362 237.0
SHD2_k127_919161_6 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000009834 218.0
SHD2_k127_919161_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000131 166.0
SHD2_k127_919161_8 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000001172 135.0
SHD2_k127_919161_9 bacterial-type flagellum-dependent cell motility K01317 - 3.4.21.10 0.00000000000003799 82.0
SHD2_k127_946658_0 XdhC Rossmann domain K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003546 272.0
SHD2_k127_946658_1 PFAM NAD binding domain of 6-phosphogluconate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000003053 267.0
SHD2_k127_946658_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001151 246.0
SHD2_k127_946658_3 HAD-hyrolase-like K06019 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001986 243.0
SHD2_k127_946658_4 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000456 137.0
SHD2_k127_946658_5 PFAM carbon monoxide dehydrogenase subunit G K09386 - - 0.00000000000000000000002253 108.0
SHD2_k127_946658_6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.00000000000000006251 89.0
SHD2_k127_946658_7 FeoA K04758 - - 0.000000000004497 70.0
SHD2_k127_946658_8 SNF2 family N-terminal domain - - - 0.000000001221 72.0
SHD2_k127_951745_0 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 409.0
SHD2_k127_951745_1 Domain of unknown function (DUF1835) - - - 0.000000000000000000000000000000000000000000000000002164 199.0
SHD2_k127_951745_2 HAD-hyrolase-like K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000002705 176.0
SHD2_k127_951745_3 Bacterial Ig-like domain - - - 0.000000000000000000000000000000000000000000000296 184.0
SHD2_k127_951745_4 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000001569 174.0
SHD2_k127_951745_5 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000002236 173.0
SHD2_k127_951745_6 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000006071 154.0
SHD2_k127_971022_0 Protein of unknown function, DUF255 K06888 - - 2.498e-249 788.0
SHD2_k127_971022_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 8.741e-234 743.0
SHD2_k127_971022_10 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 305.0
SHD2_k127_971022_11 Peptidase M61 - - - 0.0000000000000000000000000000000000000000000000000000000000000001105 252.0
SHD2_k127_971022_12 phytoene K02291 GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000004402 198.0
SHD2_k127_971022_13 endonuclease activity - - - 0.0000000000000000000000000000000004061 138.0
SHD2_k127_971022_14 Predicted integral membrane protein (DUF2269) - - - 0.00000000000000000000000000000001361 133.0
SHD2_k127_971022_15 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000001954 141.0
SHD2_k127_971022_16 B12 binding domain - - - 0.00000000000000000000000000006048 128.0
SHD2_k127_971022_17 PDZ DHR GLGF domain protein - - - 0.0000000000000000000000000354 117.0
SHD2_k127_971022_18 Thioredoxin-like [2Fe-2S] ferredoxin - - - 0.000000000000000000004393 96.0
SHD2_k127_971022_19 chaperone-mediated protein folding - - - 0.0000000000000000002505 100.0
SHD2_k127_971022_2 radical SAM domain protein - - - 7.204e-201 644.0
SHD2_k127_971022_20 PFAM phospholipid glycerol acyltransferase - - - 0.000000000007603 71.0
SHD2_k127_971022_21 Domain of unknown function (DUF4440) - - - 0.00000000001915 74.0
SHD2_k127_971022_22 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.0000334 56.0
SHD2_k127_971022_23 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00004496 55.0
SHD2_k127_971022_3 Sodium:dicarboxylate symporter family K11102 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002684 522.0
SHD2_k127_971022_4 oxidoreductase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 528.0
SHD2_k127_971022_5 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 444.0
SHD2_k127_971022_6 Belongs to the PstS family K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 389.0
SHD2_k127_971022_7 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 387.0
SHD2_k127_971022_8 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 352.0
SHD2_k127_971022_9 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 344.0