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Overview

ID MAG03383
Name SHD2_bin.8
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Thermoanaerobaculia
Order UBA5066
Family UBA5066
Genus DAOMFB01
Species
Assembly information
Completeness (%) 81.22
Contamination (%) 0.32
GC content (%) 70.0
N50 (bp) 19,509
Genome size (bp) 2,916,924

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2443

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_1048041_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 574.0
SHD2_k127_1048041_1 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 391.0
SHD2_k127_1048041_10 DNA-binding transcription factor activity - - - 0.000000000000000000000000003705 114.0
SHD2_k127_1048041_11 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000219 109.0
SHD2_k127_1048041_12 cell redox homeostasis - - - 0.00000000000000000009483 97.0
SHD2_k127_1048041_13 Redoxin - - - 0.000000003717 58.0
SHD2_k127_1048041_14 DUF167 K09131 - - 0.000000225 64.0
SHD2_k127_1048041_2 Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 390.0
SHD2_k127_1048041_3 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 331.0
SHD2_k127_1048041_4 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.000000000000000000000000000000000000000000000000000000000000000000000000003156 283.0
SHD2_k127_1048041_5 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000003696 256.0
SHD2_k127_1048041_6 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000341 204.0
SHD2_k127_1048041_7 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000000000000179 195.0
SHD2_k127_1048041_8 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000004932 188.0
SHD2_k127_1048041_9 isomerase K03271 - 5.3.1.28 0.000000000000000000000000000000000000003435 167.0
SHD2_k127_1072549_0 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 360.0
SHD2_k127_1072549_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 340.0
SHD2_k127_1072549_2 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 300.0
SHD2_k127_1076022_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.815e-230 745.0
SHD2_k127_1076022_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 547.0
SHD2_k127_1076022_10 pfam nudix - - - 0.0000000000000000000000000000000000009402 145.0
SHD2_k127_1076022_11 PFAM Iron sulphur-containing domain, CDGSH-type - - - 0.000000000000000000001836 104.0
SHD2_k127_1076022_12 Membrane - - - 0.0000000000009434 83.0
SHD2_k127_1076022_13 Protein of unknown function, DUF255 - - - 0.0000000000673 69.0
SHD2_k127_1076022_14 (FHA) domain - - - 0.0000006139 63.0
SHD2_k127_1076022_15 RDD family - - - 0.00000743 59.0
SHD2_k127_1076022_16 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0001929 54.0
SHD2_k127_1076022_17 CHAD - - - 0.0008814 51.0
SHD2_k127_1076022_2 Aminotransferase class I and II K14267 - 2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 423.0
SHD2_k127_1076022_3 C-terminal AAA-associated domain K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 385.0
SHD2_k127_1076022_4 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 312.0
SHD2_k127_1076022_5 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001454 295.0
SHD2_k127_1076022_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003132 235.0
SHD2_k127_1076022_7 cytokinin biosynthetic process K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000001713 174.0
SHD2_k127_1076022_8 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016151,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0032501,GO:0036211,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0046872,GO:0046914,GO:0048871,GO:0050897,GO:0065007,GO:0065008,GO:0071704,GO:0097009,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000000000000000000000000000000000147 183.0
SHD2_k127_1076022_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000003797 152.0
SHD2_k127_1095100_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 557.0
SHD2_k127_1095100_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 531.0
SHD2_k127_1095100_2 Protein of unknown function (DUF2867) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009375 477.0
SHD2_k127_1095100_3 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 419.0
SHD2_k127_1095100_4 Peptidase M16 K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009397 304.0
SHD2_k127_1095100_5 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004285 272.0
SHD2_k127_1095100_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000001274 200.0
SHD2_k127_1095100_7 IstB-like ATP binding protein K02315 - - 0.0000000000000000000000000000000000000000000000000000448 195.0
SHD2_k127_1095100_8 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000871 185.0
SHD2_k127_1095100_9 helix_turn_helix, mercury resistance K13640 - - 0.000000000000000000000000000109 120.0
SHD2_k127_1113294_0 cellulose binding - - - 0.0 1259.0
SHD2_k127_1113294_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.168e-245 795.0
SHD2_k127_1113294_10 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000006245 208.0
SHD2_k127_1113294_11 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000002775 176.0
SHD2_k127_1113294_12 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.000000000000000000000000000000000000000000004464 168.0
SHD2_k127_1113294_13 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000002861 155.0
SHD2_k127_1113294_14 nitric oxide dioxygenase activity - - - 0.00000000000000000000000005248 113.0
SHD2_k127_1113294_15 Domain of unknown function (DUF4136) - - - 0.0000003069 60.0
SHD2_k127_1113294_16 Belongs to the HesB IscA family K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564 - 0.00005385 54.0
SHD2_k127_1113294_2 Involved in the tonB-independent uptake of proteins - - - 1.607e-225 726.0
SHD2_k127_1113294_3 Involved in the tonB-independent uptake of proteins - - - 1.803e-196 647.0
SHD2_k127_1113294_4 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008885 569.0
SHD2_k127_1113294_5 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 440.0
SHD2_k127_1113294_6 Serine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007408 457.0
SHD2_k127_1113294_7 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 422.0
SHD2_k127_1113294_8 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001016 282.0
SHD2_k127_1113294_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000004687 230.0
SHD2_k127_1116741_0 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 462.0
SHD2_k127_1116741_1 DNA topoisomerase K02470,K02622 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001251 274.0
SHD2_k127_1116741_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.00000000000000000000209 107.0
SHD2_k127_1116741_3 ATPase kinase involved in NAD metabolism - - - 0.0000004119 54.0
SHD2_k127_1121041_0 response regulator K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000231 293.0
SHD2_k127_1121041_1 Protein tyrosine kinase - - - 0.000000000000000000000000000002124 136.0
SHD2_k127_1121041_2 sigma factor antagonist activity K04757 - 2.7.11.1 0.000000000000000000004166 98.0
SHD2_k127_1121041_3 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000002184 83.0
SHD2_k127_1121041_4 antisigma factor binding K04749 - - 0.00001324 50.0
SHD2_k127_1129943_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.162e-210 672.0
SHD2_k127_1129943_1 protease with the C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 470.0
SHD2_k127_1129943_10 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008233 335.0
SHD2_k127_1129943_11 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 340.0
SHD2_k127_1129943_12 PFAM Type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 333.0
SHD2_k127_1129943_13 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 298.0
SHD2_k127_1129943_14 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 297.0
SHD2_k127_1129943_15 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000006925 272.0
SHD2_k127_1129943_16 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000664 270.0
SHD2_k127_1129943_17 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000007668 251.0
SHD2_k127_1129943_18 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000007679 239.0
SHD2_k127_1129943_19 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000008293 196.0
SHD2_k127_1129943_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 453.0
SHD2_k127_1129943_20 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000259 196.0
SHD2_k127_1129943_21 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000391 188.0
SHD2_k127_1129943_22 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000001273 166.0
SHD2_k127_1129943_23 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000003527 132.0
SHD2_k127_1129943_24 Thioesterase domain - - - 0.00000000000000000000000000001319 136.0
SHD2_k127_1129943_25 PFAM Alpha beta hydrolase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000001871 134.0
SHD2_k127_1129943_26 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000005041 130.0
SHD2_k127_1129943_27 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.0000000000000000000000000009205 117.0
SHD2_k127_1129943_28 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000558 112.0
SHD2_k127_1129943_29 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000002484 124.0
SHD2_k127_1129943_3 e3 binding domain K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 415.0
SHD2_k127_1129943_30 protein homooligomerization - - - 0.00000000000000000000000007107 123.0
SHD2_k127_1129943_31 DUF167 K09131 - - 0.000000000000000000000001962 119.0
SHD2_k127_1129943_32 Histidine kinase K10681 - 2.7.13.3 0.00000000000000000000001196 118.0
SHD2_k127_1129943_33 EamA-like transporter family - - - 0.0000000000000000000001877 108.0
SHD2_k127_1129943_34 - - - - 0.000000000000000002903 91.0
SHD2_k127_1129943_35 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.000000000002568 79.0
SHD2_k127_1129943_36 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000009615 68.0
SHD2_k127_1129943_37 Domain of unknown function (DUF4340) - - - 0.000000057 66.0
SHD2_k127_1129943_38 protein homooligomerization - - - 0.0000002407 63.0
SHD2_k127_1129943_39 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000006211 52.0
SHD2_k127_1129943_4 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 419.0
SHD2_k127_1129943_5 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 406.0
SHD2_k127_1129943_6 argininosuccinate lyase K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 393.0
SHD2_k127_1129943_7 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006734 372.0
SHD2_k127_1129943_8 Amino acid kinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007091 371.0
SHD2_k127_1129943_9 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 347.0
SHD2_k127_1154157_0 Belongs to the malate synthase family K01638 - 2.3.3.9 2.048e-223 707.0
SHD2_k127_1154157_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 1.413e-203 643.0
SHD2_k127_1154157_10 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000004509 209.0
SHD2_k127_1154157_11 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000003137 130.0
SHD2_k127_1154157_12 Peptidase family M23 K21471 - - 0.00000000000000000000000000001148 134.0
SHD2_k127_1154157_13 SMART protein phosphatase 2C domain protein - - - 0.000000000000000000000000009117 123.0
SHD2_k127_1154157_14 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000001718 112.0
SHD2_k127_1154157_15 - - - - 0.0000001009 59.0
SHD2_k127_1154157_16 CAAX protease self-immunity - - - 0.0000005997 59.0
SHD2_k127_1154157_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 571.0
SHD2_k127_1154157_3 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 432.0
SHD2_k127_1154157_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 420.0
SHD2_k127_1154157_5 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 382.0
SHD2_k127_1154157_6 ABC transporter, ATP-binding protein K02049,K15555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005045 375.0
SHD2_k127_1154157_7 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 370.0
SHD2_k127_1154157_8 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 335.0
SHD2_k127_1154157_9 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K15257 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000001714 268.0
SHD2_k127_1163159_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 444.0
SHD2_k127_1163159_1 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.000000000000000000000000000000000000000000000000009735 186.0
SHD2_k127_1181248_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 2.064e-197 639.0
SHD2_k127_1181248_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 559.0
SHD2_k127_1181248_10 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000003838 186.0
SHD2_k127_1181248_11 PFAM Glycosyl transferase, group 1 K12994 - 2.4.1.349 0.0000000000000000000000000000000000000000002915 177.0
SHD2_k127_1181248_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000002963 113.0
SHD2_k127_1181248_13 Ribosomal L32p protein family K02911 - - 0.00000000000000000007025 90.0
SHD2_k127_1181248_14 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000001567 100.0
SHD2_k127_1181248_2 peptide catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007763 374.0
SHD2_k127_1181248_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 353.0
SHD2_k127_1181248_4 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 319.0
SHD2_k127_1181248_5 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004409 300.0
SHD2_k127_1181248_6 Glutamate carboxypeptidase II K01301 - 3.4.17.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000002879 284.0
SHD2_k127_1181248_7 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007779 281.0
SHD2_k127_1181248_8 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000004727 251.0
SHD2_k127_1181248_9 glutamate carboxypeptidase K01301 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0008150,GO:0009888,GO:0010073,GO:0012505,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048507,GO:0048856 3.4.17.21 0.0000000000000000000000000000000000000000000000000000000000000000000007791 263.0
SHD2_k127_1210996_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 529.0
SHD2_k127_1225879_0 Nucleotidyl transferase K00966 - 2.7.7.13 0.0000000000000000000000000004738 128.0
SHD2_k127_1225879_1 CYTH K05873 - 4.6.1.1 0.00000000000000000002745 101.0
SHD2_k127_1225879_2 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.00000000000000001332 88.0
SHD2_k127_1234141_0 ABC-type multidrug transport system, ATPase and permease K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 427.0
SHD2_k127_1234141_1 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000001488 229.0
SHD2_k127_1234141_2 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000001643 202.0
SHD2_k127_1234141_3 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000002047 163.0
SHD2_k127_1234141_4 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000002691 72.0
SHD2_k127_1234141_5 DNA-directed 5'-3' RNA polymerase activity K03060 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0004335 46.0
SHD2_k127_1235754_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 4.538e-235 740.0
SHD2_k127_1235754_1 SMART Elongator protein 3 MiaB NifB - - - 1.378e-215 682.0
SHD2_k127_1235754_10 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000002967 224.0
SHD2_k127_1235754_11 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000001654 174.0
SHD2_k127_1235754_12 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000003711 183.0
SHD2_k127_1235754_13 Peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000001642 133.0
SHD2_k127_1235754_14 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000001431 131.0
SHD2_k127_1235754_15 Histidine kinase - - - 0.000000000000000000000000012 128.0
SHD2_k127_1235754_16 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000004721 111.0
SHD2_k127_1235754_17 Bacterial membrane protein, YfhO - - - 0.000000000000000000000001095 121.0
SHD2_k127_1235754_18 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000005088 97.0
SHD2_k127_1235754_19 Neisseria PilC beta-propeller domain K02674 - - 0.00000000000000000001098 110.0
SHD2_k127_1235754_2 phosphoribosylamine-glycine ligase activity K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 527.0
SHD2_k127_1235754_20 DSBA-like thioredoxin domain - - - 0.00000000000000000001893 104.0
SHD2_k127_1235754_21 Biotin-requiring enzyme - - - 0.00000000000000002134 97.0
SHD2_k127_1235754_22 - - - - 0.0000000000003926 77.0
SHD2_k127_1235754_23 Multicopper oxidase - - - 0.000000000006262 66.0
SHD2_k127_1235754_24 SMART serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000421 73.0
SHD2_k127_1235754_25 Tetratricopeptide repeat - - - 0.0000002141 63.0
SHD2_k127_1235754_26 energy transducer activity K03832 - - 0.000001738 61.0
SHD2_k127_1235754_27 Type II secretion system (T2SS), protein G K02456 - - 0.000002886 57.0
SHD2_k127_1235754_28 PilX N-terminal K02673 - - 0.00006275 53.0
SHD2_k127_1235754_3 Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain-like biotin carboxylase-like K11263 - 6.3.4.14,6.4.1.2,6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 491.0
SHD2_k127_1235754_4 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 444.0
SHD2_k127_1235754_5 Bacterial regulatory protein, Fis family K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 362.0
SHD2_k127_1235754_6 twitching motility protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 357.0
SHD2_k127_1235754_7 Coenzyme A transferase K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 334.0
SHD2_k127_1235754_8 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 355.0
SHD2_k127_1235754_9 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000531 319.0
SHD2_k127_1263791_0 Type VI secretion system effector, Hcp K11903 - - 0.0000000000000006848 82.0
SHD2_k127_1263791_1 protein conserved in bacteria - - - 0.0002788 53.0
SHD2_k127_126619_0 TIGRFAM cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009532 355.0
SHD2_k127_126619_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005162 312.0
SHD2_k127_126619_10 Protein of unknown function, DUF481 K07283 - - 0.000000000002764 76.0
SHD2_k127_126619_11 Belongs to the UPF0434 family K09791 - - 0.0000009622 53.0
SHD2_k127_126619_2 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000003966 281.0
SHD2_k127_126619_3 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000001383 247.0
SHD2_k127_126619_4 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000003745 254.0
SHD2_k127_126619_5 Psort location Cytoplasmic, score K00008,K00060 - 1.1.1.103,1.1.1.14 0.00000000000000000000000000000000000000000000000000000000001018 231.0
SHD2_k127_126619_6 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.0000000000000000000000000000000000000000000000000143 189.0
SHD2_k127_126619_7 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000004033 103.0
SHD2_k127_126619_8 O-Antigen ligase K18814 - - 0.000000000000000000000006501 115.0
SHD2_k127_126619_9 Exonuclease VII small subunit - - - 0.000000000002002 70.0
SHD2_k127_1277211_0 glycosyl hydrolase, BNR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 585.0
SHD2_k127_1277211_1 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 472.0
SHD2_k127_1277211_10 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000005478 103.0
SHD2_k127_1277211_11 PFAM PKD domain containing protein - - - 0.000000000000002671 90.0
SHD2_k127_1277211_12 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.0000000000009143 82.0
SHD2_k127_1277211_13 Peptidase family M23 - - - 0.00000000000327 81.0
SHD2_k127_1277211_14 PFAM Tetrapyrrole (Corrin Porphyrin) Methylases K13542 - 2.1.1.107,4.2.1.75 0.0000000747 64.0
SHD2_k127_1277211_15 PFAM O-antigen polymerase - - - 0.0002193 54.0
SHD2_k127_1277211_16 Aminotransferase class-V - - - 0.0008175 45.0
SHD2_k127_1277211_2 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 449.0
SHD2_k127_1277211_3 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 419.0
SHD2_k127_1277211_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 377.0
SHD2_k127_1277211_5 Carbamoyl-phosphate synthetase ammonia chain K01955 GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 361.0
SHD2_k127_1277211_6 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 308.0
SHD2_k127_1277211_7 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003125 260.0
SHD2_k127_1277211_8 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000001259 242.0
SHD2_k127_1277211_9 Putative ABC exporter - - - 0.000000000000000000000000000000000000000000000000000001056 218.0
SHD2_k127_1278473_0 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 4.286e-249 775.0
SHD2_k127_1278473_1 Glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 511.0
SHD2_k127_1278473_2 Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000006525 218.0
SHD2_k127_1293924_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1036.0
SHD2_k127_1293924_1 TIGRFAM Na H antiporter, bacterial form K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 452.0
SHD2_k127_1293924_2 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 456.0
SHD2_k127_1293924_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006148 404.0
SHD2_k127_1293924_4 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 422.0
SHD2_k127_1293924_5 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001636 299.0
SHD2_k127_1293924_6 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000896 267.0
SHD2_k127_1293924_7 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000005254 217.0
SHD2_k127_1293924_8 - K00241 - - 0.0000000000000000000000000000000000000000000000000000000000001469 229.0
SHD2_k127_1293924_9 Thioesterase superfamily K10806 - - 0.0000000000000000000000000000001886 129.0
SHD2_k127_1294717_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 1.848e-231 729.0
SHD2_k127_1294717_1 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000001682 224.0
SHD2_k127_1294717_2 General secretory system II protein E domain protein K02652 - - 0.00000003319 66.0
SHD2_k127_1329406_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 1.098e-263 821.0
SHD2_k127_1332785_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 2.026e-228 725.0
SHD2_k127_1332785_1 ABC transporter, transmembrane K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 520.0
SHD2_k127_1332785_10 Pyruvate kinase, alpha/beta domain K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000208 297.0
SHD2_k127_1332785_11 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001038 296.0
SHD2_k127_1332785_12 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001073 303.0
SHD2_k127_1332785_13 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006654 295.0
SHD2_k127_1332785_14 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000002517 266.0
SHD2_k127_1332785_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006624 271.0
SHD2_k127_1332785_16 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000003273 269.0
SHD2_k127_1332785_17 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000008325 214.0
SHD2_k127_1332785_18 imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000001428 209.0
SHD2_k127_1332785_19 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000002991 203.0
SHD2_k127_1332785_2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 466.0
SHD2_k127_1332785_20 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000008113 194.0
SHD2_k127_1332785_21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 - 2.4.2.17 0.000000000000000000000000000000000000000000000000002553 205.0
SHD2_k127_1332785_22 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.000000000000000000000000000000000000000000000000009618 199.0
SHD2_k127_1332785_23 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000001668 203.0
SHD2_k127_1332785_25 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000001491 184.0
SHD2_k127_1332785_26 phosphoserine phosphatase activity K07052,K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000007062 184.0
SHD2_k127_1332785_27 Histidine biosynthesis protein K01814 - 5.3.1.16 0.000000000000000000000000000000000000000002195 172.0
SHD2_k127_1332785_28 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000001015 156.0
SHD2_k127_1332785_29 domain, Protein - - - 0.000000000000000000000000000000000002116 160.0
SHD2_k127_1332785_3 ABC transporter K06147,K18890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 494.0
SHD2_k127_1332785_30 PFAM response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000000000000002416 121.0
SHD2_k127_1332785_31 HD domain - - - 0.00000000000000000000000002174 121.0
SHD2_k127_1332785_32 Domain of unknown function (DUF4412) - - - 0.000000000000000000001474 105.0
SHD2_k127_1332785_33 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000001433 100.0
SHD2_k127_1332785_34 type I phosphodiesterase nucleotide pyrophosphatase K01513 GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002276,GO:0002366,GO:0002376,GO:0002682,GO:0002683,GO:0002684,GO:0002694,GO:0002695,GO:0002697,GO:0002698,GO:0002699,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004528,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006955,GO:0008081,GO:0008150,GO:0008152,GO:0008270,GO:0008285,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009143,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0031347,GO:0031348,GO:0032101,GO:0032102,GO:0033003,GO:0033004,GO:0033006,GO:0033007,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036230,GO:0042127,GO:0042578,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045321,GO:0045575,GO:0046034,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047429,GO:0048471,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050727,GO:0050728,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050865,GO:0050866,GO:0050896,GO:0055086,GO:0065007,GO:0070663,GO:0070664,GO:0070666,GO:0070667,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0080134,GO:0090304,GO:0090305,GO:0098552,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901575,GO:1901576 3.1.4.1,3.6.1.9 0.00000000000000843 88.0
SHD2_k127_1332785_35 Bacterial protein of unknown function (DUF885) - - - 0.000000009717 64.0
SHD2_k127_1332785_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009105 464.0
SHD2_k127_1332785_5 copper-translocating P-type ATPase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003826 439.0
SHD2_k127_1332785_6 DNA polymerase X family K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 426.0
SHD2_k127_1332785_7 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 380.0
SHD2_k127_1332785_8 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 387.0
SHD2_k127_1332785_9 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 291.0
SHD2_k127_1337354_0 TonB-dependent Receptor Plug K16092 - - 0.0000000000000000000000000000000000000000000000000000001035 217.0
SHD2_k127_1393504_0 Domain of unknown function (DUF3943) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001146 260.0
SHD2_k127_1393504_1 Domain of unknown function (DUF3943) - - - 0.00000000000000000000000000000000000000000000000000000000000008985 239.0
SHD2_k127_1393504_2 Belongs to the ompA family K03286 - - 0.000005106 60.0
SHD2_k127_140977_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009665 439.0
SHD2_k127_140977_1 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002151 271.0
SHD2_k127_140977_2 Protein of unknown function (DUF4197) - - - 0.0000000000000000000000000000000000000000000000000000000000000000004081 233.0
SHD2_k127_140977_3 Proteasome subunit K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000007291 226.0
SHD2_k127_140977_4 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000001609 182.0
SHD2_k127_140977_5 Phenazine biosynthesis-like protein K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000009725 180.0
SHD2_k127_140977_6 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000001302 63.0
SHD2_k127_1426349_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.779e-194 623.0
SHD2_k127_1426349_1 COG0607 Rhodanese-related sulfurtransferase - - - 0.00000000000000000007025 90.0
SHD2_k127_1426349_2 Putative regulatory protein - - - 0.00000002896 62.0
SHD2_k127_1438065_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008767 476.0
SHD2_k127_1438065_1 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 452.0
SHD2_k127_1438065_2 Protein of unknown function (DUF664) - - - 0.000000000000000000000000000000000000000001921 161.0
SHD2_k127_1438065_3 - - - - 0.0000000000000000000000000000007063 130.0
SHD2_k127_1438065_4 Responsible for synthesis of pseudouridine from uracil K06179,K06180 - 5.4.99.23,5.4.99.24 0.00000000000000000000000689 111.0
SHD2_k127_1441744_0 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002555 261.0
SHD2_k127_1441744_1 protein import - - - 0.00000000000000000000000000000000000000002941 165.0
SHD2_k127_1441744_2 Transcriptional regulator - - - 0.000005096 55.0
SHD2_k127_1441744_3 miRNA binding K12799,K12802 GO:0001817,GO:0001819,GO:0001932,GO:0001933,GO:0001959,GO:0001960,GO:0002376,GO:0002791,GO:0002793,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006469,GO:0006950,GO:0006952,GO:0006955,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008385,GO:0009889,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010563,GO:0010605,GO:0010646,GO:0010648,GO:0010803,GO:0010804,GO:0019219,GO:0019220,GO:0019221,GO:0019222,GO:0023051,GO:0023052,GO:0023057,GO:0031323,GO:0031324,GO:0031326,GO:0031399,GO:0031400,GO:0032088,GO:0032268,GO:0032269,GO:0032651,GO:0032652,GO:0032731,GO:0032732,GO:0032879,GO:0032880,GO:0032991,GO:0033209,GO:0033673,GO:0034097,GO:0034612,GO:0042221,GO:0042325,GO:0042326,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043433,GO:0043549,GO:0044092,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045087,GO:0045859,GO:0045936,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050704,GO:0050706,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050716,GO:0050718,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051090,GO:0051171,GO:0051172,GO:0051174,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051252,GO:0051338,GO:0051348,GO:0051716,GO:0060255,GO:0060759,GO:0060761,GO:0061695,GO:0065007,GO:0065009,GO:0070201,GO:0070887,GO:0071310,GO:0071345,GO:0071356,GO:0080090,GO:0090087,GO:1902494,GO:1902554,GO:1902911,GO:1903506,GO:1903530,GO:1903532,GO:1904951,GO:1990234,GO:2000112,GO:2001141 - 0.0004809 47.0
SHD2_k127_1476643_0 PFAM DAHP synthetase I KDSA K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 470.0
SHD2_k127_1476643_1 Peptidase dimerisation domain K12941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004986 370.0
SHD2_k127_1476643_10 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000003506 168.0
SHD2_k127_1476643_11 Cupin domain - - - 0.0000000000000000000000000001249 119.0
SHD2_k127_1476643_13 Serine aminopeptidase, S33 - - - 0.0000000000000000000000002929 116.0
SHD2_k127_1476643_14 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000006845 116.0
SHD2_k127_1476643_15 Protein of unknown function, DUF547 - - - 0.00000000000000000000002884 109.0
SHD2_k127_1476643_16 cell septum assembly - - - 0.0000000000000000000001382 109.0
SHD2_k127_1476643_18 Transposase - - - 0.000000000000000007764 94.0
SHD2_k127_1476643_19 - - - - 0.000000000000001471 84.0
SHD2_k127_1476643_2 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 351.0
SHD2_k127_1476643_20 - - - - 0.0000000000001212 84.0
SHD2_k127_1476643_21 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000001548 70.0
SHD2_k127_1476643_22 peptidyl-tyrosine sulfation - - - 0.00000000006478 75.0
SHD2_k127_1476643_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 347.0
SHD2_k127_1476643_4 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000882 334.0
SHD2_k127_1476643_5 synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001319 280.0
SHD2_k127_1476643_6 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000005415 267.0
SHD2_k127_1476643_7 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.00000000000000000000000000000000000000000000000000006053 199.0
SHD2_k127_1476643_8 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000006524 182.0
SHD2_k127_1476643_9 KR domain K07124 - - 0.000000000000000000000000000000000000000000000388 186.0
SHD2_k127_1486151_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 616.0
SHD2_k127_1486151_1 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 583.0
SHD2_k127_1486151_10 Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 310.0
SHD2_k127_1486151_11 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 295.0
SHD2_k127_1486151_12 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000003327 268.0
SHD2_k127_1486151_13 PFAM von Willebrand factor type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006987 263.0
SHD2_k127_1486151_14 PFAM Rhomboid family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000001416 231.0
SHD2_k127_1486151_15 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000437 240.0
SHD2_k127_1486151_16 Major facilitator Superfamily K06902 - - 0.000000000000000000000000000000000000000000000000000000001913 217.0
SHD2_k127_1486151_17 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000112 213.0
SHD2_k127_1486151_18 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000008159 214.0
SHD2_k127_1486151_19 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000000000000000000005346 177.0
SHD2_k127_1486151_2 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 570.0
SHD2_k127_1486151_20 GAF domain - - - 0.000000000000000000000000000000000000002269 161.0
SHD2_k127_1486151_21 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000003596 171.0
SHD2_k127_1486151_22 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000009554 142.0
SHD2_k127_1486151_23 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.000000000000000000000000000000000005557 159.0
SHD2_k127_1486151_24 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.0000000000000000000000000000000000159 152.0
SHD2_k127_1486151_25 belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.0000000000000000000000000000000006068 145.0
SHD2_k127_1486151_26 regulation of translation K03530 - - 0.000000000000000000000000000000009957 130.0
SHD2_k127_1486151_27 Oxygen tolerance - - - 0.0000000000000000000000000000005543 141.0
SHD2_k127_1486151_28 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000001827 116.0
SHD2_k127_1486151_29 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000004614 84.0
SHD2_k127_1486151_3 3-isopropylmalate dehydratase activity K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 533.0
SHD2_k127_1486151_30 endoglucanase-related protein, glucosyl hydrolase family 9 protein - - - 0.0000000000000002032 90.0
SHD2_k127_1486151_31 - - - - 0.000000000000003999 82.0
SHD2_k127_1486151_32 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000001227 68.0
SHD2_k127_1486151_33 Psort location CytoplasmicMembrane, score - - - 0.000007415 59.0
SHD2_k127_1486151_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K03918 - 2.6.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007098 512.0
SHD2_k127_1486151_5 O-acetylhomoserine K01740 - 2.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 494.0
SHD2_k127_1486151_6 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 435.0
SHD2_k127_1486151_7 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 406.0
SHD2_k127_1486151_8 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008162 404.0
SHD2_k127_1486151_9 HMGL-like K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 376.0
SHD2_k127_151505_0 PFAM GlcNAc-PI de-N-acetylase - - - 7.766e-239 767.0
SHD2_k127_151505_1 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 381.0
SHD2_k127_151505_2 CAAX protease self-immunity - - - 0.00000000007954 73.0
SHD2_k127_1568686_0 peptidase M24B X-Pro dipeptidase aminopeptidase domain protein K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 456.0
SHD2_k127_1568686_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006375 419.0
SHD2_k127_1568686_2 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 428.0
SHD2_k127_1568686_3 Bacterial membrane protein, YfhO - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 351.0
SHD2_k127_1568686_4 desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 318.0
SHD2_k127_1568686_5 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007023 272.0
SHD2_k127_1568686_6 - - - - 0.0000000000000000000000000000000000008597 143.0
SHD2_k127_1568686_7 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.51 0.00000000000000000000000000000000003958 144.0
SHD2_k127_1568686_8 SMART phosphoesterase PA-phosphatase related - - - 0.0000008588 53.0
SHD2_k127_1582809_0 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007167 453.0
SHD2_k127_1582809_1 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 399.0
SHD2_k127_1582809_10 acyl-coa-binding protein - - - 0.00000000000000000000000002484 111.0
SHD2_k127_1582809_11 PFAM Haloacid dehalogenase domain protein hydrolase type 3 K07026,K15918 - 2.7.1.31,3.1.3.70 0.0000000000000000000000007683 115.0
SHD2_k127_1582809_12 transmembrane transport - - - 0.0000000000000000003042 96.0
SHD2_k127_1582809_13 KaiC - - - 0.000003205 59.0
SHD2_k127_1582809_2 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 407.0
SHD2_k127_1582809_3 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 373.0
SHD2_k127_1582809_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000007502 252.0
SHD2_k127_1582809_5 hemerythrin HHE cation binding domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000005438 226.0
SHD2_k127_1582809_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000008788 220.0
SHD2_k127_1582809_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000001229 195.0
SHD2_k127_1582809_8 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000008466 158.0
SHD2_k127_1582809_9 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000001734 129.0
SHD2_k127_1676777_0 Tricorn protease homolog - - - 2.618e-284 915.0
SHD2_k127_1676777_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 452.0
SHD2_k127_1676777_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 298.0
SHD2_k127_1676777_3 CpeT/CpcT family (DUF1001) - - - 0.0000000000000000000000001984 113.0
SHD2_k127_1676777_4 GTPase activity K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.000003394 49.0
SHD2_k127_1685705_0 Belongs to the argininosuccinate synthase family. Type K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 517.0
SHD2_k127_1685705_1 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 338.0
SHD2_k127_1685705_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000001485 281.0
SHD2_k127_1685705_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000006159 175.0
SHD2_k127_1685705_4 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000006729 93.0
SHD2_k127_1685705_5 Sigma-70 region 2 K03088 - - 0.00000002755 64.0
SHD2_k127_1803176_0 Tricorn protease homolog K08676 - - 0.0 1073.0
SHD2_k127_1803176_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 2.097e-231 728.0
SHD2_k127_1803176_2 IgA Peptidase M64 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 484.0
SHD2_k127_1803176_3 Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 316.0
SHD2_k127_1803176_4 type I phosphodiesterase nucleotide pyrophosphatase - GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 - 0.000000000000000000000000000000000000000000000000000002366 216.0
SHD2_k127_1803176_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000005021 142.0
SHD2_k127_1803176_6 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000002559 101.0
SHD2_k127_1803176_7 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000364 106.0
SHD2_k127_1803176_8 peptidyl-tyrosine sulfation - - - 0.000000001139 68.0
SHD2_k127_194837_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 2.038e-215 687.0
SHD2_k127_194837_1 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 380.0
SHD2_k127_194837_2 Saccharopine dehydrogenase NADP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 315.0
SHD2_k127_194837_3 MscS Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002687 307.0
SHD2_k127_194837_4 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000005173 227.0
SHD2_k127_194837_5 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000004584 145.0
SHD2_k127_194837_6 Protein of unknown function (DUF1499) - - - 0.000000000000000000000001162 119.0
SHD2_k127_194837_7 helix_turn_helix, Lux Regulon - - - 0.000001113 60.0
SHD2_k127_1972084_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 430.0
SHD2_k127_1972084_1 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007936 389.0
SHD2_k127_1972084_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 346.0
SHD2_k127_1972084_3 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000004828 104.0
SHD2_k127_1972084_4 translation initiation factor activity - - - 0.0000598 46.0
SHD2_k127_198087_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006222 494.0
SHD2_k127_198087_1 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 428.0
SHD2_k127_198087_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 306.0
SHD2_k127_198087_3 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000839 252.0
SHD2_k127_198087_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000055 240.0
SHD2_k127_198087_5 cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000005805 233.0
SHD2_k127_198087_6 Domain of unknown function (DUF3488) - - - 0.000000000000000000000000000000006309 149.0
SHD2_k127_198087_7 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000003384 116.0
SHD2_k127_198087_8 Protein of unknown function DUF58 - - - 0.00000000000000000000001297 114.0
SHD2_k127_1999966_0 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 495.0
SHD2_k127_1999966_1 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 317.0
SHD2_k127_1999966_10 Membrane - - - 0.000000000000314 83.0
SHD2_k127_1999966_11 repeat-containing protein - - - 0.000587 52.0
SHD2_k127_1999966_2 VIT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008512 269.0
SHD2_k127_1999966_3 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000004248 256.0
SHD2_k127_1999966_4 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000001755 241.0
SHD2_k127_1999966_5 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000001402 202.0
SHD2_k127_1999966_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000001584 145.0
SHD2_k127_1999966_7 CoA binding domain - - - 0.0000000000000000000000000000005631 138.0
SHD2_k127_1999966_8 Domain of unknown function (DUF4286) - - - 0.0000000000000000000001505 104.0
SHD2_k127_1999966_9 Bacterial membrane protein, YfhO - - - 0.0000000000000000001346 104.0
SHD2_k127_2099574_0 signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 559.0
SHD2_k127_2099574_1 Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 347.0
SHD2_k127_2099574_2 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000001464 239.0
SHD2_k127_2099574_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000001789 192.0
SHD2_k127_2099574_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000003747 176.0
SHD2_k127_2099574_5 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.0000000000000000000000000000007966 137.0
SHD2_k127_2099574_6 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000003904 103.0
SHD2_k127_2099574_7 Ferredoxin K04755 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - 0.0000000000000001886 82.0
SHD2_k127_2099574_8 Rieske [2Fe-2S] domain - - - 0.000000000006211 77.0
SHD2_k127_2116453_0 Two component regulator propeller K07315,K12132,K13924 - 2.1.1.80,2.7.11.1,3.1.1.61,3.1.3.3 1.138e-241 785.0
SHD2_k127_2116453_1 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 602.0
SHD2_k127_2116453_10 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 314.0
SHD2_k127_2116453_11 Acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 318.0
SHD2_k127_2116453_12 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002262 260.0
SHD2_k127_2116453_13 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000004057 214.0
SHD2_k127_2116453_14 - - - - 0.0000000000000000000000000000000000000000000000000000005183 199.0
SHD2_k127_2116453_15 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000123 181.0
SHD2_k127_2116453_16 - - - - 0.0000000000000000000000000000000000000006251 166.0
SHD2_k127_2116453_17 Acyl-ACP thioesterase K01071 - 3.1.2.21 0.00000000000000000000000000000000000003163 153.0
SHD2_k127_2116453_18 NMT1-like family K02051 - - 0.0000000000000000000000000004891 126.0
SHD2_k127_2116453_19 NMT1-like family K02051 - - 0.000000000000000000000000008123 127.0
SHD2_k127_2116453_2 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 561.0
SHD2_k127_2116453_20 NMT1-like family K02051 - - 0.00000000000000000000000007856 123.0
SHD2_k127_2116453_21 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.00000000000000000000004315 101.0
SHD2_k127_2116453_22 Belongs to the P-Pant transferase superfamily K06133 - - 0.000000000005865 77.0
SHD2_k127_2116453_23 NMT1/THI5 like K02051 - - 0.00000000004963 75.0
SHD2_k127_2116453_3 Alcohol dehydrogenase GroES-like domain K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 521.0
SHD2_k127_2116453_4 Protein of unknown function (DUF3641) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 501.0
SHD2_k127_2116453_5 PFAM Aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 501.0
SHD2_k127_2116453_6 radical SAM domain protein K22318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 438.0
SHD2_k127_2116453_7 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 377.0
SHD2_k127_2116453_8 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 380.0
SHD2_k127_2116453_9 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 347.0
SHD2_k127_2116919_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 516.0
SHD2_k127_2116919_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 467.0
SHD2_k127_2116919_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 338.0
SHD2_k127_2116919_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000004244 235.0
SHD2_k127_2116919_4 Bacterial membrane protein YfhO - - - 0.000000000000000000000000000000000000000003294 178.0
SHD2_k127_2116919_5 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000003716 169.0
SHD2_k127_2116919_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000114 153.0
SHD2_k127_2116919_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000001675 124.0
SHD2_k127_2116919_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000002536 73.0
SHD2_k127_2128843_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 471.0
SHD2_k127_2128843_1 Zinc-binding alcohol dehydrogenase family protein K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 361.0
SHD2_k127_2128843_2 YceI-like domain - - - 0.000000000000000000000000000000000000000000000006876 181.0
SHD2_k127_2128843_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000329 153.0
SHD2_k127_2128843_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.000008385 50.0
SHD2_k127_2131193_0 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 616.0
SHD2_k127_2131193_1 Hydrophobe amphiphile Efflux-1 (HAE1) family K03296,K18138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008193 248.0
SHD2_k127_2131193_2 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000002331 235.0
SHD2_k127_2131193_3 PFAM EAL domain - - - 0.000000000000000000000000000000000000000000000000005323 201.0
SHD2_k127_2131193_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000003684 117.0
SHD2_k127_2131193_5 Protease prsW family - - - 0.000001587 61.0
SHD2_k127_2131193_6 Domain of unknown function (DUF4282) - - - 0.0001372 54.0
SHD2_k127_213321_0 Dehydrogenase E1 component K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000004536 212.0
SHD2_k127_213321_1 PFAM RNA binding S1 domain protein K02945 - - 0.000000000000000000000000000000000000000000000000000000005769 215.0
SHD2_k127_2153620_0 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 2.17e-312 981.0
SHD2_k127_2153620_1 Carbamoyltransferase C-terminus K00612 - - 1.501e-255 801.0
SHD2_k127_2153620_10 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000006149 201.0
SHD2_k127_2153620_11 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000009876 186.0
SHD2_k127_2153620_12 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000001776 186.0
SHD2_k127_2153620_13 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000008401 198.0
SHD2_k127_2153620_14 - - - - 0.00000003375 63.0
SHD2_k127_2153620_15 - - - - 0.0000004773 57.0
SHD2_k127_2153620_16 lipolytic protein G-D-S-L family - - - 0.000000837 61.0
SHD2_k127_2153620_17 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000001108 61.0
SHD2_k127_2153620_2 glutamate dehydrogenase [NAD(P)+] activity K00260,K00261,K00262 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 3.168e-227 708.0
SHD2_k127_2153620_3 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 617.0
SHD2_k127_2153620_4 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 486.0
SHD2_k127_2153620_5 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 459.0
SHD2_k127_2153620_6 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008875 453.0
SHD2_k127_2153620_7 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 422.0
SHD2_k127_2153620_8 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000016 252.0
SHD2_k127_2153620_9 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000003243 213.0
SHD2_k127_2162455_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 521.0
SHD2_k127_2162455_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000003019 155.0
SHD2_k127_2205685_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000471 510.0
SHD2_k127_2205685_1 Translation elongation factor K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 385.0
SHD2_k127_2205685_2 FAD-dependent dehydrogenase K07137 - - 0.00000000000000000000000003885 112.0
SHD2_k127_2215902_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000007356 281.0
SHD2_k127_2215902_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000005323 134.0
SHD2_k127_2229439_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 4.057e-228 729.0
SHD2_k127_2229439_1 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 345.0
SHD2_k127_2229439_10 Trypsin-like peptidase domain - - - 0.0004977 53.0
SHD2_k127_2229439_2 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009805 284.0
SHD2_k127_2229439_3 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001607 310.0
SHD2_k127_2229439_4 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309,K11102 - - 0.00000000000000000000000000000000000000000000000000000009796 212.0
SHD2_k127_2229439_5 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000004872 106.0
SHD2_k127_2229439_6 ig-like, plexins, transcription factors - - - 0.0000000000000002874 94.0
SHD2_k127_2229439_7 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000003016 79.0
SHD2_k127_2229439_8 PFAM Fimbrial assembly family protein K02663 - - 0.0000000001487 70.0
SHD2_k127_2229439_9 Pilus assembly protein, PilP K02664,K02665 - - 0.00001459 53.0
SHD2_k127_2238523_0 Ferrous iron transport protein B K04759 - - 7.189e-255 825.0
SHD2_k127_2238523_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 1.944e-245 773.0
SHD2_k127_2238523_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 477.0
SHD2_k127_2238523_3 Belongs to the HpcH HpaI aldolase family K01644,K14451,K18292 - 3.1.2.30,4.1.3.25,4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000129 287.0
SHD2_k127_2238523_4 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000002589 216.0
SHD2_k127_2238523_5 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000251 187.0
SHD2_k127_2238523_6 transferase activity, transferring glycosyl groups K20534 - - 0.0000000000000000000000000000000000000002104 159.0
SHD2_k127_2238523_7 - - - - 0.00000000000000000000000253 108.0
SHD2_k127_2238523_8 FeoA K04758 - - 0.000000000000000000000003718 104.0
SHD2_k127_2283404_0 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 593.0
SHD2_k127_2283404_1 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 463.0
SHD2_k127_2283404_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 317.0
SHD2_k127_2284110_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 376.0
SHD2_k127_2284110_1 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 319.0
SHD2_k127_2347857_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 525.0
SHD2_k127_2347857_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004694 519.0
SHD2_k127_2347857_10 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 306.0
SHD2_k127_2347857_11 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 292.0
SHD2_k127_2347857_12 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002279 290.0
SHD2_k127_2347857_13 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639,K20967 - 4.1.99.22,4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000004555 273.0
SHD2_k127_2347857_14 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003474 270.0
SHD2_k127_2347857_15 NlpE C-terminal OB domain - - - 0.0000000000000000000000000000000000000000000000000009719 196.0
SHD2_k127_2347857_16 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000005709 191.0
SHD2_k127_2347857_17 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000002856 162.0
SHD2_k127_2347857_18 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000003576 164.0
SHD2_k127_2347857_19 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000002063 158.0
SHD2_k127_2347857_2 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 458.0
SHD2_k127_2347857_20 non-canonical purine NTP pyrophosphatase, RdgB HAM1 family K02428 - 3.6.1.66 0.00000000000000000000000000000000007857 140.0
SHD2_k127_2347857_21 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000003712 139.0
SHD2_k127_2347857_22 Stage II sporulation D domain protein K06381 - - 0.0000000000000000000000000000003848 142.0
SHD2_k127_2347857_23 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.000000000000000000000000000001209 132.0
SHD2_k127_2347857_24 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000001513 137.0
SHD2_k127_2347857_25 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000001131 130.0
SHD2_k127_2347857_26 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000003546 101.0
SHD2_k127_2347857_27 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000001177 104.0
SHD2_k127_2347857_28 - - - - 0.0000000002184 73.0
SHD2_k127_2347857_29 Bacterial membrane protein YfhO - - - 0.0000000009546 72.0
SHD2_k127_2347857_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 432.0
SHD2_k127_2347857_4 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007606 409.0
SHD2_k127_2347857_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 356.0
SHD2_k127_2347857_6 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 363.0
SHD2_k127_2347857_7 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 350.0
SHD2_k127_2347857_8 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 313.0
SHD2_k127_2347857_9 Major facilitator K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 312.0
SHD2_k127_2370602_0 DNA RNA helicase, superfamily II, SNF2 family K08282 - 2.7.11.1 6.307e-217 711.0
SHD2_k127_2370602_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 447.0
SHD2_k127_2370602_10 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07714 - - 0.000000000000000000000000000000000000000000000000000000001733 216.0
SHD2_k127_2370602_11 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000000000000001088 202.0
SHD2_k127_2370602_12 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000004838 209.0
SHD2_k127_2370602_13 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.000000000000000000000000000000000000000000000341 176.0
SHD2_k127_2370602_14 carboxylic acid catabolic process - - - 0.000000000000000000000000000000000000004969 166.0
SHD2_k127_2370602_15 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000173 156.0
SHD2_k127_2370602_16 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.00000000000000000000000000000000005566 137.0
SHD2_k127_2370602_17 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000009725 145.0
SHD2_k127_2370602_18 Protein of unknown function (DUF420) - - - 0.0000000000000000000000000000000001529 147.0
SHD2_k127_2370602_19 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000003114 131.0
SHD2_k127_2370602_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003954 426.0
SHD2_k127_2370602_20 Hpt domain - - - 0.00000000000000000000000009755 123.0
SHD2_k127_2370602_21 Binds the 23S rRNA K02909 - - 0.0000000000000000000000001641 108.0
SHD2_k127_2370602_22 Ribosomal prokaryotic L21 protein K02888 - - 0.000000000000000000000000166 108.0
SHD2_k127_2370602_23 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000001418 111.0
SHD2_k127_2370602_24 TPM domain - - - 0.0000000000000000000008627 109.0
SHD2_k127_2370602_25 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000001263 109.0
SHD2_k127_2370602_26 Lytic murein transglycosylase K08309 - - 0.00000000000000000002584 107.0
SHD2_k127_2370602_27 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000002477 99.0
SHD2_k127_2370602_28 Phosphoglycerate mutase family K08296 - - 0.000000000000000007685 93.0
SHD2_k127_2370602_29 SWIM zinc finger - - - 0.00000000000001154 88.0
SHD2_k127_2370602_3 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 404.0
SHD2_k127_2370602_30 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000008506 77.0
SHD2_k127_2370602_31 - - - - 0.0000000000003387 81.0
SHD2_k127_2370602_32 Protein of unknown function (DUF3501) - - - 0.0000000004006 64.0
SHD2_k127_2370602_33 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.000000005289 66.0
SHD2_k127_2370602_34 - - - - 0.0001157 51.0
SHD2_k127_2370602_4 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 351.0
SHD2_k127_2370602_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001634 306.0
SHD2_k127_2370602_6 PFAM Peptidase family M20 M25 M40 K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000812 292.0
SHD2_k127_2370602_7 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000002887 246.0
SHD2_k127_2370602_8 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000002881 214.0
SHD2_k127_2370602_9 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000002964 210.0
SHD2_k127_2386578_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 438.0
SHD2_k127_2386578_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000004258 221.0
SHD2_k127_2386578_3 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000003163 144.0
SHD2_k127_2386578_4 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672,K10794 - 1.21.4.1,1.21.4.2 0.00000000000002011 75.0
SHD2_k127_2386578_5 Bacterial transcriptional activator domain - - - 0.000384 52.0
SHD2_k127_2387833_0 transcription factor binding K02584 - - 8.053e-197 627.0
SHD2_k127_2387833_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002767 289.0
SHD2_k127_2387833_2 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004423 286.0
SHD2_k127_2387833_3 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000006978 183.0
SHD2_k127_2387833_4 DinB family - - - 0.000000000000000000000000000000000000000008459 160.0
SHD2_k127_2387833_5 - - - - 0.00000000000001695 83.0
SHD2_k127_2387833_6 Short-chain dehydrogenase reductase SDR - - - 0.000000000008294 65.0
SHD2_k127_2434765_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1057.0
SHD2_k127_2434765_1 Amidinotransferase K01482 - 3.5.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000911 310.0
SHD2_k127_2434765_2 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.000000000000000002346 90.0
SHD2_k127_2434765_3 PFAM cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000008108 62.0
SHD2_k127_2487462_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 8.88e-321 1001.0
SHD2_k127_2487462_1 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 547.0
SHD2_k127_2487462_10 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000129 194.0
SHD2_k127_2487462_11 D-arabinono-1,4-lactone oxidase - - - 0.0000000000000000000000000000000000000002643 172.0
SHD2_k127_2487462_12 4Fe-4S single cluster domain K06871 GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0033554,GO:0043170,GO:0044238,GO:0050896,GO:0051604,GO:0051716,GO:0071704,GO:1901564 - 0.0000000000000005227 90.0
SHD2_k127_2487462_13 Transcriptional regulator - - - 0.0000000000002035 83.0
SHD2_k127_2487462_14 - - - - 0.00000000008311 69.0
SHD2_k127_2487462_15 Outer membrane efflux protein - - - 0.00003677 56.0
SHD2_k127_2487462_16 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0006316 53.0
SHD2_k127_2487462_2 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000834 399.0
SHD2_k127_2487462_3 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 381.0
SHD2_k127_2487462_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004373 291.0
SHD2_k127_2487462_5 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000004082 239.0
SHD2_k127_2487462_6 - - - - 0.000000000000000000000000000000000000000000000000000000659 218.0
SHD2_k127_2487462_7 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000004318 197.0
SHD2_k127_2487462_8 membrane-fusion protein - - - 0.00000000000000000000000000000000000000000000000001516 198.0
SHD2_k127_2487462_9 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000001063 199.0
SHD2_k127_2524306_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 402.0
SHD2_k127_2524306_1 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 385.0
SHD2_k127_2524306_10 von Willebrand factor, type A - - - 0.0000000000000000000002424 108.0
SHD2_k127_2524306_11 polysaccharide deacetylase - - - 0.0000000001807 73.0
SHD2_k127_2524306_12 Putative neutral zinc metallopeptidase K07054 - - 0.0000003018 56.0
SHD2_k127_2524306_13 Protein of unknown function (DUF1569) - - - 0.00002432 55.0
SHD2_k127_2524306_15 - - - - 0.0006682 47.0
SHD2_k127_2524306_2 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00520 - 1.16.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 373.0
SHD2_k127_2524306_3 acid phosphatase activity K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 370.0
SHD2_k127_2524306_4 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 335.0
SHD2_k127_2524306_5 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000001773 237.0
SHD2_k127_2524306_6 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000001121 227.0
SHD2_k127_2524306_7 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.00000000000000000000000000000000000000000007189 168.0
SHD2_k127_2524306_8 Belongs to the ompA family - - - 0.00000000000000000000000000000000000004826 151.0
SHD2_k127_2524306_9 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000002211 137.0
SHD2_k127_2571784_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 499.0
SHD2_k127_2571784_1 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 430.0
SHD2_k127_2571784_2 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001853 281.0
SHD2_k127_2571784_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000004186 225.0
SHD2_k127_2571784_4 Domain of unknown function (DUF1972) K12996 - - 0.0000000000000000000000000000000000000000000000000000000000001458 235.0
SHD2_k127_2571784_5 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000006726 239.0
SHD2_k127_2571784_6 Glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000009639 158.0
SHD2_k127_2571784_7 Glycosyl transferase family 2 - - - 0.00000000000000000000001719 114.0
SHD2_k127_2575620_0 imidazolonepropionase activity K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 351.0
SHD2_k127_2575620_1 Helix-hairpin-helix domain K04477 - - 0.00000000000000000000000000000000000000000000009059 188.0
SHD2_k127_2575620_2 5'-3' exonuclease K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000003112 164.0
SHD2_k127_2575620_3 Formiminotransferase-cyclodeaminase - - - 0.0000000000000000000000000000000004798 139.0
SHD2_k127_2575620_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000001639 117.0
SHD2_k127_2575620_5 Predicted periplasmic lipoprotein (DUF2279) - - - 0.0000000000000000000000008986 119.0
SHD2_k127_2575620_6 Cell division initiation protein K04074 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000005981 78.0
SHD2_k127_2575620_7 Eukaryotic integral membrane protein (DUF1751) - - - 0.0000000000641 72.0
SHD2_k127_2578373_0 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 3.224e-224 702.0
SHD2_k127_2578373_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 1.543e-218 712.0
SHD2_k127_2578373_10 Belongs to the peptidase S1C family K04691,K04771,K04772 - 3.4.21.107 0.00000000005562 72.0
SHD2_k127_2578373_2 peptidase K07386 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 608.0
SHD2_k127_2578373_3 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 647.0
SHD2_k127_2578373_4 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009357 398.0
SHD2_k127_2578373_5 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007889 273.0
SHD2_k127_2578373_6 Histidine kinase - - - 0.0000000000000000000000000000000000000122 166.0
SHD2_k127_2578373_7 metalloendopeptidase activity K03799 - - 0.000000000000000000000000000000001226 148.0
SHD2_k127_2578373_8 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000000000001775 118.0
SHD2_k127_2588849_0 Prolyl oligopeptidase family - - - 1.838e-216 701.0
SHD2_k127_2588849_1 serine threonine protein kinase K12132 - 2.7.11.1 2.526e-201 664.0
SHD2_k127_2588849_10 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000004962 206.0
SHD2_k127_2588849_11 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000004671 128.0
SHD2_k127_2588849_12 Zinc carboxypeptidase - - - 0.000000000001482 70.0
SHD2_k127_2588849_13 cellulase activity - - - 0.0000000006233 72.0
SHD2_k127_2588849_14 ABC transporter K06020 - 3.6.3.25 0.000004207 49.0
SHD2_k127_2588849_2 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 623.0
SHD2_k127_2588849_3 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 536.0
SHD2_k127_2588849_4 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007508 404.0
SHD2_k127_2588849_5 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 325.0
SHD2_k127_2588849_6 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005918 297.0
SHD2_k127_2588849_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000758 262.0
SHD2_k127_2588849_8 DNA-binding ferritin-like protein (Oxidative damage protectant) K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000000001221 236.0
SHD2_k127_2588849_9 - - - - 0.0000000000000000000000000000000000000000000000000000000004551 214.0
SHD2_k127_2589120_0 Large extracellular alpha-helical protein - - - 0.0 2192.0
SHD2_k127_2589120_1 4Fe-4S dicluster domain K00184 - - 3.921e-224 721.0
SHD2_k127_2589120_10 Glycosyltransferase family 87 - - - 0.000000001085 70.0
SHD2_k127_2589120_2 Alpha amylase, catalytic domain K01176 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 617.0
SHD2_k127_2589120_3 Zinc carboxypeptidase K14054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 548.0
SHD2_k127_2589120_4 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 423.0
SHD2_k127_2589120_5 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 372.0
SHD2_k127_2589120_6 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218 366.0
SHD2_k127_2589120_7 Cytochrome c7 and related cytochrome c K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006302 274.0
SHD2_k127_2589120_8 Metalloprotease, specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001373 269.0
SHD2_k127_2589120_9 Histidine kinase - - - 0.0000000000000000000005736 105.0
SHD2_k127_259646_0 Domain of Unknown Function (DUF1259) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 331.0
SHD2_k127_259646_1 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000001005 179.0
SHD2_k127_259646_2 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000001407 162.0
SHD2_k127_2601747_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001278 278.0
SHD2_k127_2601747_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000003822 122.0
SHD2_k127_2666534_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 6.37e-225 710.0
SHD2_k127_2666534_1 Alpha beta hydrolase K00627 - 2.3.1.12 0.0000000000000000000003934 107.0
SHD2_k127_2672635_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 466.0
SHD2_k127_2672635_1 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000854 278.0
SHD2_k127_2672635_2 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000000732 196.0
SHD2_k127_2672635_3 outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000038 81.0
SHD2_k127_2681830_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 517.0
SHD2_k127_2681830_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000002049 248.0
SHD2_k127_2688966_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000003462 140.0
SHD2_k127_2688966_1 Surface antigen K07277 - - 0.00000000000000003314 97.0
SHD2_k127_272510_0 PFAM FAD linked oxidase domain protein - - - 3.677e-206 649.0
SHD2_k127_272510_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 503.0
SHD2_k127_272510_10 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.00000006821 57.0
SHD2_k127_272510_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000003193 56.0
SHD2_k127_272510_12 PFAM GCN5-related N-acetyltransferase - - - 0.0000003691 61.0
SHD2_k127_272510_2 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 419.0
SHD2_k127_272510_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 413.0
SHD2_k127_272510_4 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816 - 3.6.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007673 301.0
SHD2_k127_272510_5 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006713 291.0
SHD2_k127_272510_6 PFAM Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000009886 247.0
SHD2_k127_272510_7 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000002249 165.0
SHD2_k127_272510_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K20444 - - 0.0000000000000000000000000000000000002975 156.0
SHD2_k127_272510_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000003855 57.0
SHD2_k127_2760804_0 Glycogen debranching enzyme - - - 4.911e-252 802.0
SHD2_k127_2760804_1 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 612.0
SHD2_k127_2760804_2 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 429.0
SHD2_k127_2760804_3 NAD(P)-binding Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 440.0
SHD2_k127_2800691_0 PFAM Prolyl oligopeptidase family - - - 7.156e-310 960.0
SHD2_k127_2800691_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 368.0
SHD2_k127_2800691_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 340.0
SHD2_k127_2800691_3 AAA domain K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 346.0
SHD2_k127_2800691_4 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 321.0
SHD2_k127_2800691_5 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 298.0
SHD2_k127_2800691_6 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006961 282.0
SHD2_k127_2800691_7 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000002923 241.0
SHD2_k127_2800691_8 Uncharacterized protein family UPF0054 K07042 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0050308 - 0.00000000000000000000166 101.0
SHD2_k127_280671_0 B12 binding domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1049.0
SHD2_k127_280671_1 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000643 263.0
SHD2_k127_2819985_0 Radical SAM - - - 1.133e-223 713.0
SHD2_k127_2819985_1 Glycosyl transferase family group 2 K00720 - 2.4.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000005418 263.0
SHD2_k127_2878627_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000006401 261.0
SHD2_k127_2878627_1 electron transport chain K00347,K03614 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000046 271.0
SHD2_k127_2878627_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000001173 223.0
SHD2_k127_2878627_3 SMART phosphoesterase PA-phosphatase related - - - 0.000000000000000000000000000000000003865 153.0
SHD2_k127_2878627_4 antisigma factor binding - - - 0.000000000000003135 78.0
SHD2_k127_2878627_5 gag-polyprotein putative aspartyl protease - - - 0.0003565 54.0
SHD2_k127_2918238_0 Probable zinc-ribbon domain - - - 0.000000000000000000000000000000009879 129.0
SHD2_k127_2918238_1 Deoxynucleoside kinase - - - 0.00000000000000000000000000000004047 128.0
SHD2_k127_2918238_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 0.000000000000000171 82.0
SHD2_k127_2918238_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000004783 60.0
SHD2_k127_296384_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 407.0
SHD2_k127_296384_1 Gamma-glutamyl-gamma-aminobutyrate hydrolase K07010 - - 0.000000000000000000000000000000000000000000000000000000000003832 216.0
SHD2_k127_296384_2 - - - - 0.00000000000000000000000000000000000000004271 165.0
SHD2_k127_296384_3 Protein of unknown function (DUF4197) - - - 0.000000000001128 71.0
SHD2_k127_2966757_0 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 452.0
SHD2_k127_2966757_1 asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 435.0
SHD2_k127_2966757_2 PFAM ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001382 270.0
SHD2_k127_2966757_3 belongs to the thioredoxin family K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000008058 106.0
SHD2_k127_297116_0 beta-lactamase - - - 6.45e-216 696.0
SHD2_k127_297116_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 446.0
SHD2_k127_297116_10 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000005409 101.0
SHD2_k127_297116_2 Mut7-C ubiquitin K09122 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 291.0
SHD2_k127_297116_3 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000002271 228.0
SHD2_k127_297116_4 ix monomethyl ester oxidative cyclase K04034 GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0033013,GO:0033014,GO:0034641,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.21.98.3 0.00000000000000000000000000000000000000000000000000000000003369 224.0
SHD2_k127_297116_5 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000001835 219.0
SHD2_k127_297116_6 DinB family - - - 0.000000000000000000000000000000000000000001285 161.0
SHD2_k127_297116_7 integral membrane protein - - - 0.000000000000000000000000000000000000000001489 164.0
SHD2_k127_297116_8 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000007163 163.0
SHD2_k127_297116_9 - - - - 0.00000000000000000000000000000000000002675 147.0
SHD2_k127_309714_0 Sulfatase-modifying factor enzyme 1 K11912 - 2.7.11.1 0.000001343 61.0
SHD2_k127_3172389_0 Belongs to the peptidase S16 family - - - 0.00000000000000000000000000000000000000000000008059 171.0
SHD2_k127_3172389_1 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000342 172.0
SHD2_k127_3172389_2 Universal stress protein family - - - 0.000000000000000001182 98.0
SHD2_k127_3173278_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 597.0
SHD2_k127_3173278_1 Catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 447.0
SHD2_k127_3173278_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 347.0
SHD2_k127_3173278_3 C-terminal domain of CHU protein family K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 319.0
SHD2_k127_3173278_4 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000006212 237.0
SHD2_k127_3173278_5 ATPase activity K02065 - - 0.0000000000000000000000000000000000000000000000000000000000001706 242.0
SHD2_k127_3173278_6 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000005042 165.0
SHD2_k127_3173278_7 - - - - 0.000000000001752 68.0
SHD2_k127_3181595_0 PFAM glycosyl hydrolase BNR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 473.0
SHD2_k127_3181595_1 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003425 254.0
SHD2_k127_3181595_2 Methyltransferase domain - - - 0.00000000002853 69.0
SHD2_k127_3189874_0 Magnesium chelatase, subunit ChlI K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 489.0
SHD2_k127_3189874_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 286.0
SHD2_k127_3189874_2 GTP binding K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005814 272.0
SHD2_k127_3189874_3 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008661 274.0
SHD2_k127_3189874_4 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000001093 231.0
SHD2_k127_3189874_5 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000001152 173.0
SHD2_k127_3193354_0 acetyl-CoA hydrolase K18118 - 2.8.3.18 2.941e-248 774.0
SHD2_k127_3193354_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.098e-235 787.0
SHD2_k127_3193354_10 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 426.0
SHD2_k127_3193354_11 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 390.0
SHD2_k127_3193354_12 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008697 376.0
SHD2_k127_3193354_13 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007216 370.0
SHD2_k127_3193354_14 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 362.0
SHD2_k127_3193354_15 radical SAM domain protein K06137,K06138 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000293 366.0
SHD2_k127_3193354_16 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 353.0
SHD2_k127_3193354_17 Sensor protein, DUF3365, HAMP and PAS domain-containing, heme-binding K05962 - 2.7.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 332.0
SHD2_k127_3193354_18 TRAP transporter T-component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 327.0
SHD2_k127_3193354_19 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 316.0
SHD2_k127_3193354_2 B12 binding domain K04034 - 1.21.98.3 4.127e-194 617.0
SHD2_k127_3193354_20 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 304.0
SHD2_k127_3193354_21 oligopeptide transport K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 301.0
SHD2_k127_3193354_22 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 314.0
SHD2_k127_3193354_23 Hexosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005684 291.0
SHD2_k127_3193354_24 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000008675 271.0
SHD2_k127_3193354_25 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000008549 239.0
SHD2_k127_3193354_26 PFAM L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000001866 235.0
SHD2_k127_3193354_27 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000004976 236.0
SHD2_k127_3193354_28 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000003579 232.0
SHD2_k127_3193354_29 glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000002972 218.0
SHD2_k127_3193354_3 radical SAM domain protein K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 553.0
SHD2_k127_3193354_30 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.000000000000000000000000000000000000000000000000000003035 214.0
SHD2_k127_3193354_31 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000004375 201.0
SHD2_k127_3193354_32 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000001951 177.0
SHD2_k127_3193354_33 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000006591 127.0
SHD2_k127_3193354_34 SdrD B-like domain - - - 0.00000000000000000000000000006199 137.0
SHD2_k127_3193354_35 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000000000001778 132.0
SHD2_k127_3193354_36 Beta-lactamase - - - 0.000000000000000000007002 104.0
SHD2_k127_3193354_37 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000355 91.0
SHD2_k127_3193354_38 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.000000000003108 81.0
SHD2_k127_3193354_39 histone H2A K63-linked ubiquitination K21832 - - 0.000000000447 66.0
SHD2_k127_3193354_4 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 529.0
SHD2_k127_3193354_40 Uncharacterised nucleotidyltransferase - - - 0.00000001275 68.0
SHD2_k127_3193354_41 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0000005729 58.0
SHD2_k127_3193354_43 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000006097 59.0
SHD2_k127_3193354_44 - - - - 0.0001334 53.0
SHD2_k127_3193354_5 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 523.0
SHD2_k127_3193354_6 transporter, DctM subunit K11690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 541.0
SHD2_k127_3193354_7 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 474.0
SHD2_k127_3193354_8 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 464.0
SHD2_k127_3193354_9 Bacterial regulatory protein, Fis family K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 451.0
SHD2_k127_3193378_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.365e-272 855.0
SHD2_k127_3193378_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.408e-259 812.0
SHD2_k127_3193378_10 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 323.0
SHD2_k127_3193378_11 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000001456 271.0
SHD2_k127_3193378_12 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000337 257.0
SHD2_k127_3193378_13 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000007315 235.0
SHD2_k127_3193378_14 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000001373 207.0
SHD2_k127_3193378_15 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000133 205.0
SHD2_k127_3193378_16 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000005012 211.0
SHD2_k127_3193378_17 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000002297 188.0
SHD2_k127_3193378_18 PFAM adenosine AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000004861 184.0
SHD2_k127_3193378_19 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.00000000000000000000000000000000000000000144 180.0
SHD2_k127_3193378_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007636 449.0
SHD2_k127_3193378_20 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000002106 179.0
SHD2_k127_3193378_21 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 0.00000000000000000000000000000000000613 154.0
SHD2_k127_3193378_22 Bacillithiol biosynthesis BshC K22136 - - 0.0000000000000000000000000000000003739 149.0
SHD2_k127_3193378_23 regulation of endocannabinoid signaling pathway - GO:0003674,GO:0003824,GO:0016787 - 0.00000000000000000001685 104.0
SHD2_k127_3193378_24 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000002976 107.0
SHD2_k127_3193378_25 COG0671 Membrane-associated phospholipid phosphatase - - - 0.0000000000000000004056 99.0
SHD2_k127_3193378_26 PAP2 superfamily - - - 0.00000000000000003952 93.0
SHD2_k127_3193378_27 Preprotein translocase SecG subunit K03075 - - 0.00000000000000006784 86.0
SHD2_k127_3193378_28 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000001246 85.0
SHD2_k127_3193378_29 amine dehydrogenase activity - - - 0.00000000000000719 90.0
SHD2_k127_3193378_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 416.0
SHD2_k127_3193378_30 Fatty acid desaturase - - - 0.000000000000007895 85.0
SHD2_k127_3193378_31 - - - - 0.000000000000008636 87.0
SHD2_k127_3193378_32 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit S4 paralog K04762 - - 0.00000000000001721 80.0
SHD2_k127_3193378_33 Belongs to the binding-protein-dependent transport system permease family K06921 - - 0.0000000002886 63.0
SHD2_k127_3193378_34 Domain of unknown function (DUF4870) - - - 0.0000003744 58.0
SHD2_k127_3193378_35 RDD family - - - 0.000001454 61.0
SHD2_k127_3193378_36 TIGRFAM nif11-like leader peptide domain - - - 0.0008459 49.0
SHD2_k127_3193378_4 glycosyl transferase group 1 K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 417.0
SHD2_k127_3193378_5 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 351.0
SHD2_k127_3193378_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 338.0
SHD2_k127_3193378_7 Catalyzes the conversion of dihydroorotate to orotate with NAD( ) as electron acceptor K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 336.0
SHD2_k127_3193378_8 Flavin containing amine oxidoreductase K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007602 334.0
SHD2_k127_3193378_9 PFAM glycosyl transferase family 2 K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 348.0
SHD2_k127_3196424_0 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 336.0
SHD2_k127_3196424_1 PFAM Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007195 310.0
SHD2_k127_3196424_2 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000004069 200.0
SHD2_k127_3196424_3 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000004139 155.0
SHD2_k127_3196424_4 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.000000000000000000000000000000000004629 145.0
SHD2_k127_3196424_5 phosphatase activity K07025 - - 0.0000000000000000000000000000000395 142.0
SHD2_k127_3196424_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000001439 64.0
SHD2_k127_3196424_7 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000002018 52.0
SHD2_k127_3203942_0 Amino acid adenylation domain - - - 0.0 1308.0
SHD2_k127_3203942_1 acyl-CoA dehydrogenase - - - 2.923e-237 745.0
SHD2_k127_3203942_2 - - - - 6.996e-206 644.0
SHD2_k127_3203942_3 flavin-nucleotide-binding protein structurally related to pyridoxine 5-phosphate oxidase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 545.0
SHD2_k127_3203942_4 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 359.0
SHD2_k127_3203942_5 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 347.0
SHD2_k127_3203942_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000002359 186.0
SHD2_k127_3203942_7 pyridoxamine 5-phosphate - - - 0.00000000000000000000005821 104.0
SHD2_k127_3203942_8 - - - - 0.00000000000002974 80.0
SHD2_k127_3212163_0 Predicted membrane protein (DUF2238) K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002047 285.0
SHD2_k127_3212163_1 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001842 267.0
SHD2_k127_3212163_2 ribonuclease - - - 0.00000000000000000000001128 101.0
SHD2_k127_3212163_3 Barstar (barnase inhibitor) - - - 0.00000000000000000001805 98.0
SHD2_k127_3231056_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1120.0
SHD2_k127_3231056_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 430.0
SHD2_k127_3231056_10 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000005906 246.0
SHD2_k127_3231056_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000001933 212.0
SHD2_k127_3231056_12 HlyD family secretion protein K01993 - - 0.00000000000000000000000000000000000000000000004379 182.0
SHD2_k127_3231056_13 AcrB/AcrD/AcrF family K03296 - - 0.0000000000000000000000000000000000000000008998 176.0
SHD2_k127_3231056_14 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000001412 131.0
SHD2_k127_3231056_15 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000001527 132.0
SHD2_k127_3231056_16 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.000000000000000000000006447 117.0
SHD2_k127_3231056_17 Dodecin K09165 - - 0.00000000000000000000001366 102.0
SHD2_k127_3231056_18 Preprotein translocase subunit K03210 - - 0.000000000000000000002309 98.0
SHD2_k127_3231056_19 Helix-hairpin-helix DNA-binding motif class 1 - - - 0.00000000000000000008156 98.0
SHD2_k127_3231056_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008908 372.0
SHD2_k127_3231056_20 - - - - 0.000000000000000004408 97.0
SHD2_k127_3231056_21 Histidine kinase K01768,K12132 - 2.7.11.1,4.6.1.1 0.0000000000000001583 86.0
SHD2_k127_3231056_22 Tetratricopeptide repeat - - - 0.0000000001423 72.0
SHD2_k127_3231056_23 Protein of unknown function (FYDLN_acid) - - - 0.000000001407 68.0
SHD2_k127_3231056_24 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000001774 59.0
SHD2_k127_3231056_25 Thioredoxin-like - - - 0.000003317 57.0
SHD2_k127_3231056_26 ATPase involved in DNA repair - - - 0.000004749 61.0
SHD2_k127_3231056_27 Sigma-70 region 2 K03088 - - 0.00001639 54.0
SHD2_k127_3231056_28 AAA domain - - - 0.0006748 53.0
SHD2_k127_3231056_3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 327.0
SHD2_k127_3231056_4 COG1045 Serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 314.0
SHD2_k127_3231056_5 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 297.0
SHD2_k127_3231056_6 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 310.0
SHD2_k127_3231056_7 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309,K11102 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009898 280.0
SHD2_k127_3231056_8 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001256 301.0
SHD2_k127_3231056_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003092 288.0
SHD2_k127_3244264_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 464.0
SHD2_k127_3244264_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 314.0
SHD2_k127_3244264_2 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000001136 124.0
SHD2_k127_3262568_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 1.543e-236 764.0
SHD2_k127_3262568_1 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000002346 164.0
SHD2_k127_3262568_2 Modulates RecA activity K03565 - - 0.0000000000003096 76.0
SHD2_k127_3262568_3 Tetratricopeptide repeat - - - 0.0000009825 61.0
SHD2_k127_3270298_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 564.0
SHD2_k127_3270298_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008361 554.0
SHD2_k127_3270298_10 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000008004 250.0
SHD2_k127_3270298_11 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000002045 259.0
SHD2_k127_3270298_12 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000002632 234.0
SHD2_k127_3270298_13 FecCD transport family K02015 - - 0.00000000000000000000000000000000000000000000000000000000002045 229.0
SHD2_k127_3270298_14 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000006151 211.0
SHD2_k127_3270298_15 PFAM Formiminotransferase domain K00603 - 2.1.2.5 0.000000000000000000000000000000000000000000000000008477 191.0
SHD2_k127_3270298_16 PFAM ABC transporter related K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000001391 203.0
SHD2_k127_3270298_17 PFAM Formiminotransferase K00603 - 2.1.2.5 0.0000000000000000000000000000000000000000000000009436 181.0
SHD2_k127_3270298_18 Psort location Cytoplasmic, score 8.96 K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000004132 170.0
SHD2_k127_3270298_19 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000002376 175.0
SHD2_k127_3270298_2 Bacterial regulatory protein, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 437.0
SHD2_k127_3270298_20 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000003211 160.0
SHD2_k127_3270298_21 HD domain - - - 0.00000000000000000000000000000000000001273 165.0
SHD2_k127_3270298_22 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000001956 165.0
SHD2_k127_3270298_23 Glycosyl transferase family 2 - - - 0.000000000000000000000000000004079 139.0
SHD2_k127_3270298_24 Belongs to the peptidase S8 family - - - 0.000000000000004844 90.0
SHD2_k127_3270298_25 Belongs to the peptidase S8 family - - - 0.000000000001432 81.0
SHD2_k127_3270298_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 431.0
SHD2_k127_3270298_4 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 413.0
SHD2_k127_3270298_5 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 331.0
SHD2_k127_3270298_6 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 333.0
SHD2_k127_3270298_7 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 293.0
SHD2_k127_3270298_8 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006429 310.0
SHD2_k127_3270298_9 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000006828 271.0
SHD2_k127_3272280_0 Dehydrogenase E1 component K11381 - 1.2.4.4 2.209e-244 764.0
SHD2_k127_3272280_1 Doubled CXXCH motif (Paired_CXXCH_1) - - - 5.308e-212 683.0
SHD2_k127_3272280_10 Glycine-zipper domain - - - 0.00000000000000000000402 101.0
SHD2_k127_3272280_11 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000002551 96.0
SHD2_k127_3272280_13 palmitoyl-(protein) hydrolase activity K06999 - - 0.0000000001842 74.0
SHD2_k127_3272280_16 Heat resistant agglutinin 1 protein - - - 0.000007705 56.0
SHD2_k127_3272280_17 - - - - 0.000129 53.0
SHD2_k127_3272280_18 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0004828 44.0
SHD2_k127_3272280_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 483.0
SHD2_k127_3272280_3 AsmA-like C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006566 426.0
SHD2_k127_3272280_4 arylsulfatase A K01130 - 3.1.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 379.0
SHD2_k127_3272280_5 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009721 311.0
SHD2_k127_3272280_6 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 299.0
SHD2_k127_3272280_7 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000001601 213.0
SHD2_k127_3272280_8 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000000000000000000000000004578 196.0
SHD2_k127_3272280_9 - K01992,K19341 - - 0.00000000000000000000000000000000000000002119 163.0
SHD2_k127_3297085_0 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 299.0
SHD2_k127_3297085_1 Two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.0000000000000000000000000000000000000000000000000000001434 201.0
SHD2_k127_3303661_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 413.0
SHD2_k127_3303661_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 398.0
SHD2_k127_3303661_10 Single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.00000000000000000006313 98.0
SHD2_k127_3303661_11 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000006098 83.0
SHD2_k127_3303661_12 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000006043 63.0
SHD2_k127_3303661_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008208 355.0
SHD2_k127_3303661_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003522 288.0
SHD2_k127_3303661_4 ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007664 295.0
SHD2_k127_3303661_5 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000003982 248.0
SHD2_k127_3303661_6 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000008089 186.0
SHD2_k127_3303661_7 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000008752 128.0
SHD2_k127_3303661_8 phosphocarrier protein HPr K11189 - - 0.0000000000000000000001907 101.0
SHD2_k127_3303661_9 PFAM PTS system fructose subfamily IIA component K02793 - 2.7.1.191 0.0000000000000000000007092 100.0
SHD2_k127_3316872_0 serine threonine protein kinase K12132 - 2.7.11.1 1.016e-205 672.0
SHD2_k127_3316872_1 Peptidase M16 inactive domain K07263 - - 4.709e-201 654.0
SHD2_k127_3316872_10 response regulator K02481,K07715 - - 0.000000000000000000000000000000000000000000000001477 198.0
SHD2_k127_3316872_11 ligase activity - - - 0.00000000000000000000000000000000000000001701 162.0
SHD2_k127_3316872_12 Histidine kinase - - - 0.00000000000000000000000000000000007734 149.0
SHD2_k127_3316872_13 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000971 130.0
SHD2_k127_3316872_14 Thioesterase-like superfamily K07107 - - 0.0000000000000000502 88.0
SHD2_k127_3316872_15 bacterial-type flagellum-dependent cell motility K02396,K13276 - - 0.0000000000001147 86.0
SHD2_k127_3316872_16 helix_turn_helix, Lux Regulon - - - 0.0000000001056 71.0
SHD2_k127_3316872_17 cobalamin-transporting ATPase activity K02014 - - 0.0000007522 57.0
SHD2_k127_3316872_2 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 625.0
SHD2_k127_3316872_3 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 483.0
SHD2_k127_3316872_4 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 424.0
SHD2_k127_3316872_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 351.0
SHD2_k127_3316872_6 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000001383 265.0
SHD2_k127_3316872_7 deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000001605 226.0
SHD2_k127_3316872_8 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000006921 218.0
SHD2_k127_3316872_9 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000001284 206.0
SHD2_k127_333114_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 9.36e-196 638.0
SHD2_k127_333114_1 tRNA synthetase class II core domain (G, H, P, S and T) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 359.0
SHD2_k127_333114_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000008665 210.0
SHD2_k127_3346452_0 Uncharacterized membrane protein (DUF2298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 615.0
SHD2_k127_3346452_1 PFAM NHL repeat containing protein - - - 0.000000000000000002438 102.0
SHD2_k127_3346452_2 lipolytic protein G-D-S-L family - - - 0.0000000000005029 81.0
SHD2_k127_3396420_0 S-adenosylhomocysteine deaminase activity - - - 1.473e-270 857.0
SHD2_k127_3396420_1 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 581.0
SHD2_k127_3396420_10 C-terminal domain of CHU protein family K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 327.0
SHD2_k127_3396420_11 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 317.0
SHD2_k127_3396420_12 Mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 308.0
SHD2_k127_3396420_13 Bacterial extracellular solute-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001833 271.0
SHD2_k127_3396420_14 Dehydrogenase reductase SDR family member K11168 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008629 276.0
SHD2_k127_3396420_15 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000001756 229.0
SHD2_k127_3396420_16 PFAM glycosyl transferase family 39 K14340 - - 0.00000000000000000000000000000000000000000000000004161 204.0
SHD2_k127_3396420_17 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K11991 - 3.5.4.1,3.5.4.33 0.000000000000000000000000000000000000000000000002967 184.0
SHD2_k127_3396420_18 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000007691 185.0
SHD2_k127_3396420_19 Transcription factor zinc-finger - - - 0.000000000000000000000000000000004637 144.0
SHD2_k127_3396420_2 PFAM peptidase M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 554.0
SHD2_k127_3396420_20 (twin-arginine translocation) pathway signal - - - 0.0000000000000000000000000001858 123.0
SHD2_k127_3396420_21 PFAM MgtC family K07507 - - 0.0000000000000000000000000006179 125.0
SHD2_k127_3396420_22 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000002086 109.0
SHD2_k127_3396420_23 Stage II sporulation protein E (SpoIIE) K07315 - 3.1.3.3 0.0000000000000000000000003504 123.0
SHD2_k127_3396420_24 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000005936 111.0
SHD2_k127_3396420_25 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000006168 110.0
SHD2_k127_3396420_26 Sensors of blue-light using FAD - - - 0.00000000000000000001704 96.0
SHD2_k127_3396420_27 acyl carrier protein - - - 0.0000000003595 63.0
SHD2_k127_3396420_28 Glycosyltransferase family 87 K13671 - - 0.000000002084 70.0
SHD2_k127_3396420_29 PFAM nucleic acid binding, OB-fold, tRNA - - - 0.0002219 53.0
SHD2_k127_3396420_3 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 546.0
SHD2_k127_3396420_30 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0005346 44.0
SHD2_k127_3396420_4 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000099 487.0
SHD2_k127_3396420_5 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 439.0
SHD2_k127_3396420_6 ABC transporter K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 415.0
SHD2_k127_3396420_7 Uracil DNA glycosylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 360.0
SHD2_k127_3396420_8 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 370.0
SHD2_k127_3396420_9 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 328.0
SHD2_k127_3431162_0 PFAM Binding-protein-dependent transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 297.0
SHD2_k127_3431162_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000002519 242.0
SHD2_k127_3431162_2 response regulator K07714 - - 0.00000000000000000000000000000000000000000000000000000000000003319 246.0
SHD2_k127_3431162_3 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000004691 223.0
SHD2_k127_3431162_4 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000000000000000000002422 203.0
SHD2_k127_3431162_5 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.000000000000000000000000000000001545 139.0
SHD2_k127_3431162_6 - - - - 0.0000000000004154 83.0
SHD2_k127_3435399_0 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 368.0
SHD2_k127_3435399_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000003634 231.0
SHD2_k127_3435399_2 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000002421 189.0
SHD2_k127_3435399_3 Putative DNA-binding domain - - - 0.00000000000000000000000004912 120.0
SHD2_k127_3435399_4 - - - - 0.00000000000004961 79.0
SHD2_k127_3435399_5 Sporulation and spore germination - - - 0.00000005759 63.0
SHD2_k127_3455924_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K12368,K15580,K16199,K19226 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000006393 167.0
SHD2_k127_3455924_1 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000001233 117.0
SHD2_k127_3478864_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.751e-299 931.0
SHD2_k127_3478864_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.104e-218 692.0
SHD2_k127_3478864_10 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000001407 170.0
SHD2_k127_3478864_11 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000001814 134.0
SHD2_k127_3478864_2 Amino acid permease - - - 1.107e-215 687.0
SHD2_k127_3478864_3 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 434.0
SHD2_k127_3478864_4 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 390.0
SHD2_k127_3478864_5 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 340.0
SHD2_k127_3478864_6 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000001167 226.0
SHD2_k127_3478864_7 COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.000000000000000000000000000000000000000000000000000002435 206.0
SHD2_k127_3478864_8 Belongs to the Dps family K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000001451 199.0
SHD2_k127_3478864_9 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000009133 184.0
SHD2_k127_3492471_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003186 297.0
SHD2_k127_3492471_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.0000000000000000000000000000000000000000000000000000000000001732 224.0
SHD2_k127_3492471_2 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000008 186.0
SHD2_k127_3492471_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000001327 183.0
SHD2_k127_3492471_4 Ribosomal protein S2 K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000139 172.0
SHD2_k127_3492471_5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000273 156.0
SHD2_k127_3492471_6 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000001913 136.0
SHD2_k127_3492471_7 - - - - 0.00000004037 61.0
SHD2_k127_3510776_0 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 550.0
SHD2_k127_3510776_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 531.0
SHD2_k127_3510776_10 Heat shock protein DnaJ domain protein - - - 0.000000000000000000000000000000000000000001883 179.0
SHD2_k127_3510776_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 407.0
SHD2_k127_3510776_3 oligosaccharyl transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 415.0
SHD2_k127_3510776_4 PFAM Peptidase M16 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002912 284.0
SHD2_k127_3510776_5 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000001182 241.0
SHD2_k127_3510776_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000001591 192.0
SHD2_k127_3510776_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000007778 182.0
SHD2_k127_3510776_8 peptidase, M16 K07263,K07623 - - 0.0000000000000000000000000000000000000000000000002388 193.0
SHD2_k127_3510776_9 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000008867 184.0
SHD2_k127_3532663_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1154.0
SHD2_k127_3602403_0 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 408.0
SHD2_k127_3602403_1 Aldehyde dehydrogenase K00128 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 294.0
SHD2_k127_3602403_2 serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000002892 236.0
SHD2_k127_3602403_3 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000001906 165.0
SHD2_k127_3602403_4 phosphatase activity K01560,K07025,K08723,K20862 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2 0.00000000000000000000000000000000000000000003412 171.0
SHD2_k127_3602403_5 Redoxin - - - 0.00000215 58.0
SHD2_k127_3689141_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000807 565.0
SHD2_k127_3689141_1 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K01571,K01960 - 4.1.1.3,6.4.1.1 0.00000000000000000000000000000000002704 140.0
SHD2_k127_3689141_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000003073 126.0
SHD2_k127_3689141_3 Tetratricopeptide repeat K00661,K18626 - 2.3.1.79 0.0000000183 67.0
SHD2_k127_3712983_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679,K01744 - 4.2.1.2,4.3.1.1 5.033e-204 647.0
SHD2_k127_3712983_1 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 401.0
SHD2_k127_3712983_2 Enoyl-CoA hydratase/isomerase K11264 - 4.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000001884 251.0
SHD2_k127_3712983_3 PFAM von Willebrand factor type A - - - 0.0000000000000000000003595 111.0
SHD2_k127_3712983_4 Transport and Golgi organisation 2 - - - 0.0007 43.0
SHD2_k127_3749717_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 - 1.17.1.4 8.238e-199 648.0
SHD2_k127_3749717_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 421.0
SHD2_k127_3749717_10 MobA-like NTP transferase domain - - - 0.00000000000000000000002402 108.0
SHD2_k127_3749717_11 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000001818 107.0
SHD2_k127_3749717_2 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003953 400.0
SHD2_k127_3749717_3 DnaJ central domain K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 370.0
SHD2_k127_3749717_4 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000007011 280.0
SHD2_k127_3749717_5 Hsp70 protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000295 248.0
SHD2_k127_3749717_6 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.000000000000000000000000000000000000000000002469 183.0
SHD2_k127_3749717_7 maturation factor XdhC CoxF family K07402 - - 0.00000000000000000000000000000000000000000003756 170.0
SHD2_k127_3749717_8 CoA binding domain - - - 0.000000000000000000000000004412 116.0
SHD2_k127_3749717_9 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000008017 119.0
SHD2_k127_3766885_0 amino acid K03294 - - 8.861e-242 756.0
SHD2_k127_3766885_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 340.0
SHD2_k127_3766885_2 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 345.0
SHD2_k127_3766885_3 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001069 283.0
SHD2_k127_3766885_4 spore coat K01790 - 5.1.3.13 0.0000000000000000000000003299 123.0
SHD2_k127_3766885_5 Universal stress protein family - - - 0.000000000000004842 85.0
SHD2_k127_3766885_6 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000001895 61.0
SHD2_k127_3895372_0 FAD linked oxidases, C-terminal domain K18930 - - 2.022e-258 806.0
SHD2_k127_3895372_1 alginic acid biosynthetic process - - - 0.000000000000000004762 87.0
SHD2_k127_3896040_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1377.0
SHD2_k127_3896040_1 Peptidase S46 - - - 1.503e-287 905.0
SHD2_k127_3896040_10 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 419.0
SHD2_k127_3896040_11 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006641 389.0
SHD2_k127_3896040_12 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 364.0
SHD2_k127_3896040_13 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 313.0
SHD2_k127_3896040_14 peptidyl-prolyl isomerase K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000002238 287.0
SHD2_k127_3896040_15 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000007006 250.0
SHD2_k127_3896040_16 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000008528 243.0
SHD2_k127_3896040_17 Quinolinate phosphoribosyl transferase, N-terminal domain K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000008958 224.0
SHD2_k127_3896040_18 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000005785 172.0
SHD2_k127_3896040_19 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000006325 151.0
SHD2_k127_3896040_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 3.822e-265 827.0
SHD2_k127_3896040_20 Citrate transporter - - - 0.000000000000000000000000001345 127.0
SHD2_k127_3896040_21 shape-determining protein MreC K03570 - - 0.00000000000000002916 93.0
SHD2_k127_3896040_22 Diacylglycerol kinase catalytic domain - - - 0.00000000000003216 85.0
SHD2_k127_3896040_24 PFAM FecR protein - - - 0.0000000003487 72.0
SHD2_k127_3896040_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 3.311e-212 669.0
SHD2_k127_3896040_4 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 555.0
SHD2_k127_3896040_5 cell shape determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 538.0
SHD2_k127_3896040_6 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 568.0
SHD2_k127_3896040_7 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 500.0
SHD2_k127_3896040_8 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 431.0
SHD2_k127_3896040_9 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 443.0
SHD2_k127_3909134_0 ABC transporter K06020 - 3.6.3.25 3.303e-250 782.0
SHD2_k127_3909134_1 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 435.0
SHD2_k127_3909134_2 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004873 280.0
SHD2_k127_3909134_3 enzyme related to lactoylglutathione lyase K06996 - - 0.000000000000000000000000000000000000000000000000000000000004718 226.0
SHD2_k127_3949067_0 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 444.0
SHD2_k127_3949067_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000004173 160.0
SHD2_k127_3949067_2 palmitoyl-(protein) hydrolase activity K06999 - - 0.00000006877 57.0
SHD2_k127_3949067_3 FAD linked oxidases, C-terminal domain K18930 - - 0.0000005062 57.0
SHD2_k127_3972870_0 COGs COG1629 Outer membrane receptor protein mostly Fe transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 420.0
SHD2_k127_3972870_1 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 323.0
SHD2_k127_3972870_2 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000004933 246.0
SHD2_k127_3972870_3 Tetratricopeptide repeat - - - 0.0000005271 61.0
SHD2_k127_3972870_4 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0004464 51.0
SHD2_k127_397899_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 459.0
SHD2_k127_397899_1 PFAM SMP-30 Gluconolaconase - - - 0.0001211 45.0
SHD2_k127_404928_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 580.0
SHD2_k127_404928_1 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.0000000000000000000000000000001621 138.0
SHD2_k127_404928_2 ferredoxin - - - 0.000000000000000000000000001465 117.0
SHD2_k127_404928_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000002019 123.0
SHD2_k127_4053141_0 methionine synthase K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 612.0
SHD2_k127_4053141_1 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 374.0
SHD2_k127_4053141_2 Major royal jelly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 347.0
SHD2_k127_4053141_3 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 331.0
SHD2_k127_4053141_4 MobA-like NTP transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 324.0
SHD2_k127_4181314_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 612.0
SHD2_k127_4181314_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 497.0
SHD2_k127_4181314_11 Protein of unknown function (DUF1569) - - - 0.0000006267 62.0
SHD2_k127_4181314_2 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 432.0
SHD2_k127_4181314_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006035 398.0
SHD2_k127_4181314_4 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 299.0
SHD2_k127_4181314_5 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004785 275.0
SHD2_k127_4181314_6 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001288 242.0
SHD2_k127_4181314_7 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000000000000000000000000000000000001968 255.0
SHD2_k127_4181314_8 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000004665 109.0
SHD2_k127_4181314_9 Cupin 2, conserved barrel domain protein - - - 0.0000000000005601 75.0
SHD2_k127_4238509_0 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 520.0
SHD2_k127_4240904_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 349.0
SHD2_k127_4240904_1 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009281 332.0
SHD2_k127_4240904_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000001151 147.0
SHD2_k127_4240904_3 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000001038 78.0
SHD2_k127_4248622_0 Sortilin, neurotensin receptor 3, - - - 8.239e-197 628.0
SHD2_k127_4248622_1 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 526.0
SHD2_k127_4248622_2 ABC-type multidrug transport system ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 376.0
SHD2_k127_4248622_3 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001491 257.0
SHD2_k127_4248622_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000001569 193.0
SHD2_k127_4250962_0 serine-type peptidase activity K01278 - 3.4.14.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 378.0
SHD2_k127_4250962_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000001139 158.0
SHD2_k127_4250962_2 HpcH/HpaI aldolase/citrate lyase family - - - 0.00000000000000000000000000000000003994 141.0
SHD2_k127_4262139_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1227.0
SHD2_k127_4262139_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 547.0
SHD2_k127_4262139_10 response regulator, receiver K01120 - 3.1.4.17 0.000003663 60.0
SHD2_k127_4262139_2 Dihydroxyacetone kinase family K07030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 390.0
SHD2_k127_4262139_3 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000462 287.0
SHD2_k127_4262139_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000001146 227.0
SHD2_k127_4262139_5 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000002888 231.0
SHD2_k127_4262139_6 long-chain fatty acid transporting porin activity K06076 - - 0.0000000000000000000000000000000000000004251 165.0
SHD2_k127_4262139_7 PFAM OmpA MotB domain protein K03640 - - 0.0000000000000000000000000000000004307 143.0
SHD2_k127_4262139_8 lipase activity K15349 - - 0.00000000000000000000000007349 125.0
SHD2_k127_4262139_9 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.000000000000000000000000283 120.0
SHD2_k127_4282260_0 PFAM Protein synthesis factor, GTP-binding K06207 - - 3.962e-246 773.0
SHD2_k127_4282260_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 355.0
SHD2_k127_4282260_10 Domain of unknown function DUF11 - - - 0.0001026 55.0
SHD2_k127_4282260_2 Flotillin K07192 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 326.0
SHD2_k127_4282260_3 RNA polymerase sigma factor K03088 - - 0.000000000000000000000000000000000000002075 155.0
SHD2_k127_4282260_4 Rhomboid family - - - 0.000000000000000003771 99.0
SHD2_k127_4282260_5 - - - - 0.0000000004903 67.0
SHD2_k127_4282260_6 - - - - 0.000004607 55.0
SHD2_k127_4282260_7 PFAM pentapeptide repeat protein - - - 0.000004824 53.0
SHD2_k127_4282260_8 - - - - 0.000007716 56.0
SHD2_k127_4282260_9 - - - - 0.00001705 56.0
SHD2_k127_4286894_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.11e-234 750.0
SHD2_k127_4286894_1 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 545.0
SHD2_k127_4286894_2 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 433.0
SHD2_k127_4286894_3 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 390.0
SHD2_k127_4286894_4 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 368.0
SHD2_k127_4286894_5 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000003035 171.0
SHD2_k127_4286894_6 RHS Repeat - - - 0.000000000000000000000005193 121.0
SHD2_k127_4286894_7 - - - - 0.000000005455 68.0
SHD2_k127_4298101_0 topoisomerase K02469 - 5.99.1.3 1.75e-263 833.0
SHD2_k127_4298101_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000118 267.0
SHD2_k127_4298101_2 - - - - 0.0000000000000000000000000000000000000000000000001662 198.0
SHD2_k127_4298101_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000004574 169.0
SHD2_k127_4316235_0 Amino acid permease - - - 2.374e-197 636.0
SHD2_k127_4316235_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 4.559e-196 624.0
SHD2_k127_4316235_10 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 314.0
SHD2_k127_4316235_11 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000004782 260.0
SHD2_k127_4316235_12 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000002505 242.0
SHD2_k127_4316235_13 Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000003684 237.0
SHD2_k127_4316235_14 PFAM Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000001536 239.0
SHD2_k127_4316235_15 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000002803 236.0
SHD2_k127_4316235_16 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000001271 175.0
SHD2_k127_4316235_17 PFAM cytochrome c assembly protein - - - 0.000000000000000000117 99.0
SHD2_k127_4316235_18 Molybdenum ABC transporter K02020 - - 0.000000000006426 76.0
SHD2_k127_4316235_19 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000117 79.0
SHD2_k127_4316235_2 helicase superfamily c-terminal domain K03732 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 438.0
SHD2_k127_4316235_20 oxidoreductase activity - - - 0.00000000153 72.0
SHD2_k127_4316235_21 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000004507 66.0
SHD2_k127_4316235_22 peptidyl-tyrosine sulfation - - - 0.000006073 60.0
SHD2_k127_4316235_23 Membrane - - - 0.00008631 55.0
SHD2_k127_4316235_24 Zn-dependent protease - - - 0.0006674 51.0
SHD2_k127_4316235_3 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000837 419.0
SHD2_k127_4316235_4 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 419.0
SHD2_k127_4316235_5 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 435.0
SHD2_k127_4316235_6 Involved in the biosynthesis of porphyrin-containing compound K02495 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 420.0
SHD2_k127_4316235_7 Belongs to the aldehyde dehydrogenase family K00135,K22445 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 413.0
SHD2_k127_4316235_8 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 376.0
SHD2_k127_4316235_9 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 319.0
SHD2_k127_4342930_0 cyclic 2,3-diphosphoglycerate synthetase activity - - - 1.671e-204 647.0
SHD2_k127_4342930_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 603.0
SHD2_k127_4342930_10 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006112 289.0
SHD2_k127_4342930_11 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000001026 260.0
SHD2_k127_4342930_12 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.000000000000000000000000000000000000000000000000000000000000000000002509 238.0
SHD2_k127_4342930_13 Histidinol phosphate phosphatase, HisJ family K04486 - 3.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000431 229.0
SHD2_k127_4342930_14 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000007702 216.0
SHD2_k127_4342930_15 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000004906 215.0
SHD2_k127_4342930_16 Protein of unknown function (DUF2400) K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000004298 194.0
SHD2_k127_4342930_17 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744,K09774,K22110 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659 - 0.0000000000000000000000000000000000000000000000828 194.0
SHD2_k127_4342930_18 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006403,GO:0006405,GO:0006409,GO:0006611,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006886,GO:0006913,GO:0008104,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0015031,GO:0015833,GO:0015931,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0031503,GO:0033036,GO:0034613,GO:0034641,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046483,GO:0046496,GO:0046907,GO:0050657,GO:0050658,GO:0051031,GO:0051156,GO:0051168,GO:0051169,GO:0051179,GO:0051186,GO:0051234,GO:0051236,GO:0051641,GO:0051649,GO:0052689,GO:0055086,GO:0070727,GO:0071166,GO:0071426,GO:0071431,GO:0071702,GO:0071704,GO:0071705,GO:0072524,GO:0097064,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.00000000000000000000000000000000000000001389 164.0
SHD2_k127_4342930_19 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000000000000000000001332 168.0
SHD2_k127_4342930_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 589.0
SHD2_k127_4342930_20 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000004461 117.0
SHD2_k127_4342930_21 Integral membrane protein DUF92 - GO:0005575,GO:0016020 - 0.000000000000000000222 105.0
SHD2_k127_4342930_22 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.000000000000002767 87.0
SHD2_k127_4342930_23 UbiA prenyltransferase family K17105 - 2.5.1.42 0.00000000000002106 87.0
SHD2_k127_4342930_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 450.0
SHD2_k127_4342930_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 373.0
SHD2_k127_4342930_5 Coenzyme A transferase K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 331.0
SHD2_k127_4342930_6 Coenzyme A transferase K01029 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 319.0
SHD2_k127_4342930_7 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 319.0
SHD2_k127_4342930_8 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 307.0
SHD2_k127_4342930_9 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004968 295.0
SHD2_k127_4359754_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - 3.837e-237 760.0
SHD2_k127_4359754_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 344.0
SHD2_k127_4359754_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 341.0
SHD2_k127_4359754_3 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000002207 221.0
SHD2_k127_4359754_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000005773 211.0
SHD2_k127_4359754_5 - - - - 0.00000000000000000000000000000000000000000000000000008124 204.0
SHD2_k127_4359754_6 Glycosyltransferase like family 2 - - - 0.00000000000000000001211 108.0
SHD2_k127_4362264_0 PFAM short-chain dehydrogenase reductase SDR K15314 - - 0.0 2079.0
SHD2_k127_4362264_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 1.37e-246 771.0
SHD2_k127_4362264_10 Ferredoxin - - - 0.000000000000000000000000000000000000000000001921 175.0
SHD2_k127_4362264_11 COG1073 Hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000001037 161.0
SHD2_k127_4362264_12 COGs COG3603 conserved K09707 - - 0.0000000000000000000000000000000000007022 151.0
SHD2_k127_4362264_13 COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA K06169 - - 0.000000000000000000000000002003 128.0
SHD2_k127_4362264_14 Transcriptional regulator - - - 0.000000000000000000000000002044 116.0
SHD2_k127_4362264_15 - - - - 0.00000000000000000000000001517 126.0
SHD2_k127_4362264_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.4e-215 692.0
SHD2_k127_4362264_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008019 610.0
SHD2_k127_4362264_4 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005345 569.0
SHD2_k127_4362264_5 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 499.0
SHD2_k127_4362264_6 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 408.0
SHD2_k127_4362264_7 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 411.0
SHD2_k127_4362264_8 With LivFGHM is involved in the high affinity leucine transport K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 370.0
SHD2_k127_4362264_9 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 357.0
SHD2_k127_4364587_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 609.0
SHD2_k127_4364587_1 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009834 404.0
SHD2_k127_4364587_2 Squalene/phytoene synthase K00801 - 2.5.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000019 252.0
SHD2_k127_4364587_3 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000764 226.0
SHD2_k127_4364587_4 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000002846 195.0
SHD2_k127_4364587_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000008597 155.0
SHD2_k127_4364587_6 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively K01243 - 3.2.2.9 0.0005152 51.0
SHD2_k127_4369189_0 Elongation factor G, domain IV K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 445.0
SHD2_k127_4369189_1 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 430.0
SHD2_k127_4369189_2 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000006772 274.0
SHD2_k127_4369189_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000002833 144.0
SHD2_k127_4369189_4 - - - - 0.00007344 45.0
SHD2_k127_4371620_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009072 541.0
SHD2_k127_4371620_1 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 372.0
SHD2_k127_4371620_2 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000001986 242.0
SHD2_k127_4371620_3 PFAM Dynamin family protein - - - 0.0000000000000000000000000000000001371 138.0
SHD2_k127_4371620_4 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000012 125.0
SHD2_k127_4371620_5 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000003844 110.0
SHD2_k127_4371620_6 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000001002 105.0
SHD2_k127_4391192_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004165 551.0
SHD2_k127_4391192_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 485.0
SHD2_k127_4391192_10 Methyltransferase domain - - - 0.00000000000000125 89.0
SHD2_k127_4391192_11 GTP binding K06883 - - 0.00001155 48.0
SHD2_k127_4391192_12 PFAM O-Antigen - - - 0.00005612 57.0
SHD2_k127_4391192_2 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 364.0
SHD2_k127_4391192_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004531 247.0
SHD2_k127_4391192_4 of the beta-lactamase K00784 - 3.1.26.11 0.0000000000000000000000000000000000000001691 160.0
SHD2_k127_4391192_5 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000000002673 172.0
SHD2_k127_4391192_6 methyltransferase activity K04786,K12240,K13613,K15677 - - 0.0000000000000000000000000000002634 136.0
SHD2_k127_4391192_7 Histidine kinase K07315 - 3.1.3.3 0.00000000000000000000000000002164 132.0
SHD2_k127_4391192_8 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000002251 108.0
SHD2_k127_4391192_9 Redoxin - - - 0.0000000000000000008032 94.0
SHD2_k127_4452264_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 329.0
SHD2_k127_4452264_1 TonB-dependent receptor - - - 0.0000000000000000000005134 111.0
SHD2_k127_4453748_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 594.0
SHD2_k127_4453748_1 PFAM ribonuclease II K01147 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 589.0
SHD2_k127_4453748_2 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007062 604.0
SHD2_k127_4453748_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 574.0
SHD2_k127_4453748_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 536.0
SHD2_k127_4453748_5 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 546.0
SHD2_k127_4453748_6 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 341.0
SHD2_k127_4453748_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000006696 256.0
SHD2_k127_4453748_8 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.000000000000000000000473 96.0
SHD2_k127_4460376_0 Belongs to the MurCDEF family K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007444 409.0
SHD2_k127_4460376_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 339.0
SHD2_k127_4460376_2 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000721 258.0
SHD2_k127_4460376_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000003758 185.0
SHD2_k127_4460376_4 Fibronectin, type III domain - - - 0.0000000000000002747 93.0
SHD2_k127_4460376_5 Protein of unknown function (DUF1573) - - - 0.00000000001737 76.0
SHD2_k127_4509654_0 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 471.0
SHD2_k127_4509654_1 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.0000000000000000000000000000000000000000000000000002259 197.0
SHD2_k127_4509654_2 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000005313 180.0
SHD2_k127_4509654_3 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000001083 168.0
SHD2_k127_4509654_4 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000003992 164.0
SHD2_k127_4509654_5 Belongs to the Fur family K09825 - - 0.0000000000000000000000000000000008997 134.0
SHD2_k127_4509654_6 PFAM Enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000005733 104.0
SHD2_k127_4509654_7 Metallo-beta-lactamase superfamily - - - 0.00000000000001016 85.0
SHD2_k127_455439_0 RF-1 domain K15034 - - 0.00000000000000000000000001597 113.0
SHD2_k127_455439_1 HI0933-like protein K07007 - - 0.00000000000000000000001711 100.0
SHD2_k127_455439_2 Translation initiation factor K03113 - - 0.0000000000000000000008735 109.0
SHD2_k127_455439_3 PFAM Tetratricopeptide - - - 0.0001866 50.0
SHD2_k127_4562320_0 Peptidase m28 - - - 6.403e-205 653.0
SHD2_k127_4562320_1 AMP-binding enzyme C-terminal domain K18660,K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 437.0
SHD2_k127_4562320_2 Aspartyl protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008318 282.0
SHD2_k127_4562320_3 Abc transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001267 274.0
SHD2_k127_4562320_4 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000007241 242.0
SHD2_k127_4562320_5 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000008858 221.0
SHD2_k127_4562320_6 transport system permease K01998 - - 0.0000000000000000000000000000000000000000000000000000000000001506 233.0
SHD2_k127_4562320_7 diguanylate cyclase - - - 0.000000000000000000000000000000001298 142.0
SHD2_k127_457520_0 Phosphoesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 611.0
SHD2_k127_457520_1 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000002589 149.0
SHD2_k127_4597465_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.255e-247 780.0
SHD2_k127_4597465_1 COG1613 ABC-type sulfate transport system, periplasmic component K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 437.0
SHD2_k127_4597465_2 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 356.0
SHD2_k127_4597465_3 Binding-protein-dependent transport system inner membrane component K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004528 316.0
SHD2_k127_4597465_4 sulfate ABC transporter K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 305.0
SHD2_k127_4597465_5 Pterin binding enzyme K00796,K13941 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000001728 211.0
SHD2_k127_4597465_6 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000001138 190.0
SHD2_k127_4633063_0 Prolyl oligopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 555.0
SHD2_k127_4633063_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 489.0
SHD2_k127_4633063_10 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K00558,K07457,K10773 - 2.1.1.37,4.2.99.18 0.00000000000000000000000000000000000000005625 169.0
SHD2_k127_4633063_11 ABC-type Mn2 Zn2 transport system, permease component K09816,K09819,K19976 - - 0.000000000000000000000000000000000001351 157.0
SHD2_k127_4633063_12 Psort location Cytoplasmic, score 8.96 - - - 0.00000000000000000000000000000000003239 148.0
SHD2_k127_4633063_13 ATPases associated with a variety of cellular activities K09820,K11603,K11710,K19973 - 3.6.3.35 0.000000000000000000000000000005188 136.0
SHD2_k127_4633063_14 - - - - 0.0000000000000000000000003436 118.0
SHD2_k127_4633063_15 Outer membrane lipoprotein-sorting protein - - - 0.000000000006094 75.0
SHD2_k127_4633063_16 Psort location Cytoplasmic, score - - - 0.00000003623 66.0
SHD2_k127_4633063_2 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 348.0
SHD2_k127_4633063_3 ABC 3 transport family K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 323.0
SHD2_k127_4633063_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 297.0
SHD2_k127_4633063_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 298.0
SHD2_k127_4633063_6 lipoprotein localization to outer membrane K02004,K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003479 291.0
SHD2_k127_4633063_7 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001249 249.0
SHD2_k127_4633063_8 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000003639 248.0
SHD2_k127_4633063_9 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.000000000000000000000000000000000000000000000000001053 196.0
SHD2_k127_4674343_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 597.0
SHD2_k127_4674343_1 Glycyl-tRNA synthetase beta subunit K01879,K14164 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 500.0
SHD2_k127_4674343_10 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000009448 100.0
SHD2_k127_4674343_2 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 433.0
SHD2_k127_4674343_3 PFAM glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 422.0
SHD2_k127_4674343_4 imidazolonepropionase activity K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 366.0
SHD2_k127_4674343_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 338.0
SHD2_k127_4674343_6 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 294.0
SHD2_k127_4674343_7 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000007437 180.0
SHD2_k127_4674343_8 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000002835 158.0
SHD2_k127_4674343_9 Transcription elongation factor, N-terminal - - - 0.00000000000000000000000001025 127.0
SHD2_k127_4724772_0 protein-disulfide reductase activity K04084,K06196 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 428.0
SHD2_k127_4724772_1 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 385.0
SHD2_k127_4724772_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000001562 228.0
SHD2_k127_4724772_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000003401 201.0
SHD2_k127_4724772_4 PFAM diacylglycerol kinase catalytic region - - - 0.00000000000000000000000000000000000000000000008689 185.0
SHD2_k127_4724772_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000004276 137.0
SHD2_k127_4724772_6 Domain of unknown function (DUF4136) - - - 0.0000000000000000000000007364 112.0
SHD2_k127_4724772_7 Bacterial membrane protein, YfhO - - - 0.00000000006325 76.0
SHD2_k127_4724772_8 2Fe-2S -binding domain - - - 0.0000000003584 64.0
SHD2_k127_4893582_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 335.0
SHD2_k127_4893582_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 306.0
SHD2_k127_4893582_2 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001395 285.0
SHD2_k127_4893582_3 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004363 263.0
SHD2_k127_4893582_4 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000001859 246.0
SHD2_k127_4893582_5 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000002133 247.0
SHD2_k127_4893582_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000006903 220.0
SHD2_k127_4893582_7 glutamate decarboxylase activity K01593 - 4.1.1.105,4.1.1.28 0.00000000000000000000000000000000000000000013 165.0
SHD2_k127_4893582_8 Transcriptional regulator - - - 0.0000000007761 65.0
SHD2_k127_4895703_0 Transport of potassium into the cell K03549 - - 3.137e-207 670.0
SHD2_k127_4895703_1 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005428 612.0
SHD2_k127_4895703_10 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000316 213.0
SHD2_k127_4895703_11 Transglutaminase-like superfamily - - - 0.0000000000000000000000000008173 123.0
SHD2_k127_4895703_12 Cytidylate kinase-like family K00945 - 2.7.4.25 0.00000000000000000008914 103.0
SHD2_k127_4895703_13 Response regulator receiver domain - - - 0.0000000000001924 83.0
SHD2_k127_4895703_2 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 537.0
SHD2_k127_4895703_3 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 509.0
SHD2_k127_4895703_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 434.0
SHD2_k127_4895703_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 388.0
SHD2_k127_4895703_6 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009599 327.0
SHD2_k127_4895703_7 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002921 276.0
SHD2_k127_4895703_8 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000002963 258.0
SHD2_k127_4895703_9 Belongs to the peptidase M24B family K01271,K01274 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000765 228.0
SHD2_k127_4903282_0 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 312.0
SHD2_k127_4903282_1 DoxX-like family - - - 0.0000000000000000000000000000000000000004341 150.0
SHD2_k127_4903282_2 outer membrane efflux protein - - - 0.0000000000000000000002068 104.0
SHD2_k127_4903282_3 Yip1 domain - - - 0.00000000001825 74.0
SHD2_k127_4937876_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 404.0
SHD2_k127_4937876_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000001682 248.0
SHD2_k127_4937876_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000003237 172.0
SHD2_k127_4937876_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000002336 163.0
SHD2_k127_4937876_4 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000001018 135.0
SHD2_k127_4937876_5 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000761 63.0
SHD2_k127_5048161_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 593.0
SHD2_k127_5048161_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 414.0
SHD2_k127_5109144_0 aspartate--ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 1.592e-196 619.0
SHD2_k127_5109144_1 Periplasmic copper-binding protein (NosD) K07218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 604.0
SHD2_k127_5109144_10 lipoprotein involved in nitrous oxide reduction K19342 - - 0.000000000000000000000000000000000000000004899 171.0
SHD2_k127_5109144_12 Transcriptional regulator, Crp Fnr family - - - 0.00000000000000000000000004164 125.0
SHD2_k127_5109144_13 lipoprotein involved in nitrous oxide reduction - - - 0.000000000000000002875 86.0
SHD2_k127_5109144_2 signal peptide peptidase K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 511.0
SHD2_k127_5109144_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005255 533.0
SHD2_k127_5109144_4 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 353.0
SHD2_k127_5109144_5 ABC transporter K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 360.0
SHD2_k127_5109144_6 ABC-2 family transporter protein K19341 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 341.0
SHD2_k127_5109144_7 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001253 246.0
SHD2_k127_5109144_8 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000454 209.0
SHD2_k127_5109144_9 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000009174 192.0
SHD2_k127_5112920_0 Ribosomal protein S5, C-terminal domain K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000002841 210.0
SHD2_k127_5112920_1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000004118 193.0
SHD2_k127_5112920_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000001022 172.0
SHD2_k127_5112920_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000622 172.0
SHD2_k127_5112920_4 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000001576 159.0
SHD2_k127_5112920_5 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000027 129.0
SHD2_k127_5112920_6 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000006187 91.0
SHD2_k127_5112920_7 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000002197 71.0
SHD2_k127_519653_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.872e-204 661.0
SHD2_k127_519653_1 Acetolactate synthase, large subunit K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 561.0
SHD2_k127_519653_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004255 481.0
SHD2_k127_519653_3 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 434.0
SHD2_k127_519653_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 406.0
SHD2_k127_519653_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 381.0
SHD2_k127_519653_6 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 362.0
SHD2_k127_519653_7 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0008397 52.0
SHD2_k127_5221572_0 6-phosphofructokinase activity K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009272 587.0
SHD2_k127_5221572_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 519.0
SHD2_k127_5221572_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000009222 168.0
SHD2_k127_5221572_3 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000001119 123.0
SHD2_k127_5286402_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 476.0
SHD2_k127_5286402_1 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 467.0
SHD2_k127_5286402_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001355 278.0
SHD2_k127_5286402_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000796 81.0
SHD2_k127_5294780_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000547 533.0
SHD2_k127_5294780_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000832 454.0
SHD2_k127_5294780_10 Redoxin K03564 - 1.11.1.15 0.000000000000000003509 87.0
SHD2_k127_5294780_11 peptidase inhibitor activity - - - 0.0000000000000001216 94.0
SHD2_k127_5294780_13 PAP2 superfamily - - - 0.000000000000003465 90.0
SHD2_k127_5294780_14 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.11.1.15 0.000000000002701 67.0
SHD2_k127_5294780_15 prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000003993 73.0
SHD2_k127_5294780_16 Bacteriophage replication gene A protein (GPA) - - - 0.0000000006732 61.0
SHD2_k127_5294780_17 Tetratricopeptide repeat - - - 0.00000001301 68.0
SHD2_k127_5294780_18 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589,K13052 - - 0.0000626 57.0
SHD2_k127_5294780_19 S-layer homology domain - - - 0.0003711 53.0
SHD2_k127_5294780_2 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004262 426.0
SHD2_k127_5294780_20 - - - - 0.0008703 43.0
SHD2_k127_5294780_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 421.0
SHD2_k127_5294780_4 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01885,K01894 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009066 322.0
SHD2_k127_5294780_5 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 303.0
SHD2_k127_5294780_6 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000001026 260.0
SHD2_k127_5294780_7 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000001166 237.0
SHD2_k127_5294780_8 TM2 domain - - - 0.0000000000000000000005418 108.0
SHD2_k127_5294780_9 Methyltransferase domain - - - 0.0000000000000000000008018 104.0
SHD2_k127_5316808_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000003219 246.0
SHD2_k127_5316808_1 TIGRFAM MazG family protein K02428,K04765 - 3.6.1.66,3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000001831 240.0
SHD2_k127_5316808_2 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000002962 213.0
SHD2_k127_5316808_3 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000001538 194.0
SHD2_k127_5316808_4 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000002023 165.0
SHD2_k127_5316808_5 Divergent polysaccharide deacetylase K09798 - - 0.000000000000000000000000000000000002883 152.0
SHD2_k127_5316808_6 Tetratricopeptide repeat - - - 0.0000000000000000000000000000348 136.0
SHD2_k127_5316808_7 Domain of unknown function (DUF1844) - - - 0.0000000008633 65.0
SHD2_k127_5325713_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 520.0
SHD2_k127_5325713_1 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006621 317.0
SHD2_k127_5325713_10 PFAM Glycosyl transferases group 1 - - - 0.00000000000000001415 96.0
SHD2_k127_5325713_11 Glycosyltransferase like family 2 K16870 - 2.4.1.289 0.000000000000001968 88.0
SHD2_k127_5325713_12 Glycosyl transferases group 1 - - - 0.000000000000001992 88.0
SHD2_k127_5325713_13 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000398 89.0
SHD2_k127_5325713_14 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000002204 74.0
SHD2_k127_5325713_15 Acetyltransferase (GNAT) domain - - - 0.000000001733 69.0
SHD2_k127_5325713_17 sequence-specific DNA binding - - - 0.0006611 48.0
SHD2_k127_5325713_2 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002484 283.0
SHD2_k127_5325713_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000001712 229.0
SHD2_k127_5325713_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000002075 224.0
SHD2_k127_5325713_5 AsnC family - - - 0.000000000000000000000000000001818 125.0
SHD2_k127_5325713_6 ABC-2 type transporter K09690 - - 0.00000000000000000000000000001405 132.0
SHD2_k127_5325713_7 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.000000000000000000000000006243 120.0
SHD2_k127_5325713_8 PKD domain - - - 0.0000000000000000000000001091 126.0
SHD2_k127_5325713_9 Phosphoribosyl transferase domain - - - 0.0000000000000000000000002289 117.0
SHD2_k127_5326952_0 Carbamoyl-phosphate synthetase ammonia chain K01955 GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.0 1024.0
SHD2_k127_5326952_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 2.133e-278 873.0
SHD2_k127_5326952_10 von Willebrand factor, type A - - - 0.0000000000000000000000000000003087 143.0
SHD2_k127_5326952_11 histone H2A K63-linked ubiquitination - - - 0.000000000000000000000000009117 123.0
SHD2_k127_5326952_12 chaperone-mediated protein folding - - - 0.00000000000005735 87.0
SHD2_k127_5326952_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 482.0
SHD2_k127_5326952_3 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 366.0
SHD2_k127_5326952_4 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 347.0
SHD2_k127_5326952_5 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 345.0
SHD2_k127_5326952_6 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 314.0
SHD2_k127_5326952_7 homoserine kinase K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000002994 211.0
SHD2_k127_5326952_9 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000000002908 141.0
SHD2_k127_5330692_0 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 2.649e-237 762.0
SHD2_k127_5330692_1 Aminotransferase K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007843 478.0
SHD2_k127_5330692_10 AMMECR1 K09141 - - 0.000000000000000000000000000000000001476 154.0
SHD2_k127_5330692_11 hydrolase of the alpha beta superfamily K07018 - - 0.0000000000000000000000000000001287 132.0
SHD2_k127_5330692_12 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.000000000000000000000000001274 123.0
SHD2_k127_5330692_13 PFAM response regulator receiver K07657 - - 0.00000000000000000000000694 117.0
SHD2_k127_5330692_14 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 0.00000000000005977 74.0
SHD2_k127_5330692_15 EamA-like transporter family - - - 0.0000000000003319 80.0
SHD2_k127_5330692_2 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 408.0
SHD2_k127_5330692_3 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006446 339.0
SHD2_k127_5330692_4 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 351.0
SHD2_k127_5330692_5 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 339.0
SHD2_k127_5330692_6 PFAM EAL domain - - - 0.000000000000000000000000000000000000000000000000000002554 211.0
SHD2_k127_5330692_7 The glycine cleavage system catalyzes the degradation of glycine K00605,K06980,K22086 - 1.5.99.5,2.1.2.10 0.00000000000000000000000000000000000000000000000007014 200.0
SHD2_k127_5330692_8 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000003125 185.0
SHD2_k127_5330692_9 peptidylprolyl isomerase, FKBP-type K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000000006721 159.0
SHD2_k127_5349801_0 PFAM BNR Asp-box repeat - - - 0.0 1044.0
SHD2_k127_5349801_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 1.643e-200 641.0
SHD2_k127_5349801_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 398.0
SHD2_k127_5349801_3 Haemolysin-III related K11068 - - 0.000000000000000000000000000000000000000000000000000000000000004029 244.0
SHD2_k127_5349801_4 PFAM sodium calcium exchanger membrane region K07300 - - 0.000000000000000000000000000000000000000000000007447 174.0
SHD2_k127_5349801_6 - - - - 0.000000000000000001932 101.0
SHD2_k127_5370193_0 Ferrous iron transport protein B K04759 - - 2.26e-216 685.0
SHD2_k127_5370193_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 364.0
SHD2_k127_5370193_2 FeoA K04758 - - 0.000000000000000001465 89.0
SHD2_k127_5551802_0 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 2.44e-213 669.0
SHD2_k127_5551802_1 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 482.0
SHD2_k127_5551802_10 - - - - 0.000000000000000005927 92.0
SHD2_k127_5551802_11 - - - - 0.000000000001691 81.0
SHD2_k127_5551802_12 phosphorelay signal transduction system - - - 0.000000001735 65.0
SHD2_k127_5551802_13 HEAT repeats - - - 0.000000003962 69.0
SHD2_k127_5551802_2 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 403.0
SHD2_k127_5551802_3 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002501 241.0
SHD2_k127_5551802_4 Molybdenum cofactor synthesis domain protein K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000002715 238.0
SHD2_k127_5551802_5 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000007125 191.0
SHD2_k127_5551802_6 - - - - 0.0000000000000000000000000000000000000001737 156.0
SHD2_k127_5551802_7 DinB superfamily - - - 0.00000000000000000000000473 116.0
SHD2_k127_5551802_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000004407 110.0
SHD2_k127_5551802_9 methyltransferase - - - 0.00000000000000000179 100.0
SHD2_k127_5554897_0 malic protein domain protein K00029 - 1.1.1.40 1.724e-204 647.0
SHD2_k127_5554897_1 Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 561.0
SHD2_k127_5554897_10 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000001468 143.0
SHD2_k127_5554897_11 Winged helix DNA-binding domain - - - 0.0000000000000000000000000002708 119.0
SHD2_k127_5554897_12 Tetratricopeptide repeat - - - 0.000000000000000000000000008705 128.0
SHD2_k127_5554897_13 Putative ATP-binding cassette K01992 - - 0.000000003057 70.0
SHD2_k127_5554897_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 535.0
SHD2_k127_5554897_3 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 389.0
SHD2_k127_5554897_4 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 359.0
SHD2_k127_5554897_5 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000008384 267.0
SHD2_k127_5554897_6 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000000000000000000000000000000000000000001663 203.0
SHD2_k127_5554897_7 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000006965 198.0
SHD2_k127_5554897_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000002049 161.0
SHD2_k127_5554897_9 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000002455 166.0
SHD2_k127_5579684_0 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 367.0
SHD2_k127_5579684_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000002023 225.0
SHD2_k127_5579684_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000006536 146.0
SHD2_k127_5579684_3 Protein of unknown function (DUF2892) - - - 0.000000000000000001922 89.0
SHD2_k127_5580240_0 cellulose binding - - - 1.678e-270 884.0
SHD2_k127_5580240_1 ABC transporter transmembrane K11085 - - 5.872e-248 801.0
SHD2_k127_5580240_10 Saccharopine dehydrogenase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 340.0
SHD2_k127_5580240_11 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000001411 224.0
SHD2_k127_5580240_12 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000004402 198.0
SHD2_k127_5580240_13 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000006045 186.0
SHD2_k127_5580240_14 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000008798 184.0
SHD2_k127_5580240_15 DinB family - - - 0.00000000000000000000000000000000009105 151.0
SHD2_k127_5580240_16 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000001837 111.0
SHD2_k127_5580240_17 RNA recognition motif - - - 0.00000000000000000000002995 101.0
SHD2_k127_5580240_18 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000003041 78.0
SHD2_k127_5580240_2 D-aminoacylase domain protein K01465,K06015 - 3.5.1.81,3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 509.0
SHD2_k127_5580240_3 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 517.0
SHD2_k127_5580240_4 phosphoribosylamine-glycine ligase activity K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 507.0
SHD2_k127_5580240_5 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 497.0
SHD2_k127_5580240_6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006462 446.0
SHD2_k127_5580240_7 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 426.0
SHD2_k127_5580240_8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 353.0
SHD2_k127_5580240_9 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 342.0
SHD2_k127_5594926_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.246e-250 817.0
SHD2_k127_5594926_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 5.853e-248 803.0
SHD2_k127_5594926_10 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 314.0
SHD2_k127_5594926_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006773 308.0
SHD2_k127_5594926_12 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004773 275.0
SHD2_k127_5594926_13 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000003627 248.0
SHD2_k127_5594926_14 TolB amino-terminal domain K03641 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000001228 246.0
SHD2_k127_5594926_15 chorismate binding enzyme K01665,K03342 - 2.6.1.85,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000006805 217.0
SHD2_k127_5594926_16 LysM domain - - - 0.0000000000000000000000000000000000000000000000000000000008082 223.0
SHD2_k127_5594926_17 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000003002 211.0
SHD2_k127_5594926_18 SpoIVB peptidase S55 - - - 0.00000000000000000000000000000000000000000000000000000002152 221.0
SHD2_k127_5594926_19 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000001058 202.0
SHD2_k127_5594926_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 6.615e-228 735.0
SHD2_k127_5594926_20 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000001337 202.0
SHD2_k127_5594926_21 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000002684 192.0
SHD2_k127_5594926_22 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000003349 192.0
SHD2_k127_5594926_23 MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000000000000000000004749 194.0
SHD2_k127_5594926_24 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000007044 181.0
SHD2_k127_5594926_25 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000002038 188.0
SHD2_k127_5594926_26 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000003232 146.0
SHD2_k127_5594926_27 DoxX - - - 0.00000000000000000000000000000000358 134.0
SHD2_k127_5594926_28 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000001631 138.0
SHD2_k127_5594926_29 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000004593 131.0
SHD2_k127_5594926_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 567.0
SHD2_k127_5594926_30 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000003215 118.0
SHD2_k127_5594926_31 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.0000000000000000000000000004175 119.0
SHD2_k127_5594926_32 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000001794 124.0
SHD2_k127_5594926_33 Domain of unknown function (DUF4126) - - - 0.00000000000000000006294 105.0
SHD2_k127_5594926_34 - - - - 0.0000000000000005609 80.0
SHD2_k127_5594926_35 Lipopolysaccharide-assembly - - - 0.0000000000000005914 93.0
SHD2_k127_5594926_36 PKD domain K01179,K08651 - 3.2.1.4,3.4.21.66 0.0000000000006436 83.0
SHD2_k127_5594926_37 Amino-transferase class IV K02619 - 4.1.3.38 0.000000000006951 79.0
SHD2_k127_5594926_38 TIGRFAM TonB family K03832 - - 0.0000000005659 72.0
SHD2_k127_5594926_39 Binds directly to 16S ribosomal RNA K02968 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00006071 55.0
SHD2_k127_5594926_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 483.0
SHD2_k127_5594926_40 Domain of unknown function (DUF4388) - - - 0.0009605 51.0
SHD2_k127_5594926_5 Pro-kumamolisin, activation domain K08677 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007022 415.0
SHD2_k127_5594926_6 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000911 349.0
SHD2_k127_5594926_7 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 346.0
SHD2_k127_5594926_8 extracellular solute-binding protein, family 5 K02035,K13893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 330.0
SHD2_k127_5594926_9 PFAM PfkB domain protein K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 319.0
SHD2_k127_5647577_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 503.0
SHD2_k127_5647577_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 377.0
SHD2_k127_5647577_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003875 273.0
SHD2_k127_5647577_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000005492 184.0
SHD2_k127_5647577_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000001413 180.0
SHD2_k127_5647577_5 structural constituent of ribosome K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000001685 164.0
SHD2_k127_5647577_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000001765 163.0
SHD2_k127_5647577_7 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000001598 69.0
SHD2_k127_5647577_8 O-linked GlcNAc transferase-putative TPR-containing transmembrane protein - - - 0.0001344 55.0
SHD2_k127_5689000_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 2.278e-279 878.0
SHD2_k127_5689000_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 547.0
SHD2_k127_5689000_2 Alanine dehydrogenase/PNT, C-terminal domain K00324 GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0097159,GO:1901265,GO:1901363 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 357.0
SHD2_k127_5689000_3 HlyD family secretion protein K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 321.0
SHD2_k127_5689000_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000001773 126.0
SHD2_k127_5689000_5 - - - - 0.0000000000000000000000002508 106.0
SHD2_k127_5689000_6 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000000000004862 111.0
SHD2_k127_5689000_7 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000003941 91.0
SHD2_k127_5750736_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 500.0
SHD2_k127_5750736_1 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 421.0
SHD2_k127_5750736_10 PAP2 superfamily - - - 0.000000000000000000000000009585 128.0
SHD2_k127_5750736_11 Tetratricopeptide repeat - - - 0.000000004106 68.0
SHD2_k127_5750736_12 protein conserved in bacteria - - - 0.00009244 52.0
SHD2_k127_5750736_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 377.0
SHD2_k127_5750736_3 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 339.0
SHD2_k127_5750736_4 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 311.0
SHD2_k127_5750736_5 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 299.0
SHD2_k127_5750736_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 299.0
SHD2_k127_5750736_7 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000156 235.0
SHD2_k127_5750736_8 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000004977 194.0
SHD2_k127_5750736_9 NUDIX domain - - - 0.0000000000000000000000000000000000003526 159.0
SHD2_k127_5774126_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000001118 207.0
SHD2_k127_5774126_1 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000000006519 183.0
SHD2_k127_5774126_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000318 183.0
SHD2_k127_5774126_3 PFAM Glycosyl transferase family 2 K20444 - - 0.000000000000000000000000000000000001533 152.0
SHD2_k127_5774126_4 Glycosyltransferase, group 2 family protein - - - 0.00000000000000000000000000000000001137 148.0
SHD2_k127_5774126_5 glycosyl transferase family 2 - - - 0.000000000000000000000002168 120.0
SHD2_k127_5774126_6 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000005996 99.0
SHD2_k127_5774126_7 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000002063 70.0
SHD2_k127_5774126_8 3-demethylubiquinone-9 3-O-methyltransferase activity K00568,K15257 - 2.1.1.222,2.1.1.64 0.000004857 57.0
SHD2_k127_5774126_9 PFAM PEGA domain - - - 0.0001196 55.0
SHD2_k127_5849137_0 COGs COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase alpha subunit K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 508.0
SHD2_k127_5849137_1 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005442 310.0
SHD2_k127_5849137_2 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 302.0
SHD2_k127_5849137_3 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000003816 224.0
SHD2_k127_5849137_4 TIGRFAM diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000002883 166.0
SHD2_k127_5849137_5 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000006252 113.0
SHD2_k127_5901650_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 415.0
SHD2_k127_5901650_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000045 175.0
SHD2_k127_5901650_2 Protein of unknown function (DUF971) - - - 0.000000000000000000000001688 109.0
SHD2_k127_5906846_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1169.0
SHD2_k127_5906846_1 PFAM Peptidase family M20 M25 M40 K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 322.0
SHD2_k127_5906846_2 Sugar (and other) transporter K08151 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006798 282.0
SHD2_k127_5906846_3 Pfam:DUF59 - - - 0.00000000000000000000000000000000000000000000000001802 200.0
SHD2_k127_5906846_4 Domain of unknown function DUF302 - - - 0.0000000000000000000000000002644 121.0
SHD2_k127_5906846_5 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000007075 114.0
SHD2_k127_5906846_6 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000001998 97.0
SHD2_k127_5906846_7 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.00000000000000000005241 105.0
SHD2_k127_5906846_8 Bacterial regulatory proteins, tetR family - - - 0.0000000000002799 84.0
SHD2_k127_6121781_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 3.313e-233 730.0
SHD2_k127_6121781_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 502.0
SHD2_k127_6121781_10 O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000003976 242.0
SHD2_k127_6121781_11 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000000000000000000000000000000001042 241.0
SHD2_k127_6121781_12 PFAM Branched-chain amino acid transport system permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000001614 246.0
SHD2_k127_6121781_13 Tautomerase enzyme - - - 0.0000000000000000000000000000000000000000000004326 169.0
SHD2_k127_6121781_14 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000006974 167.0
SHD2_k127_6121781_15 Protein of unknown function (DUF1304) K08987 - - 0.0000000000000000000000000000000007446 149.0
SHD2_k127_6121781_16 NTPase - - - 0.00000000000000005094 83.0
SHD2_k127_6121781_17 Lipase maturation factor - - - 0.000004772 59.0
SHD2_k127_6121781_2 PFAM Alcohol dehydrogenase zinc-binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006829 397.0
SHD2_k127_6121781_3 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 358.0
SHD2_k127_6121781_4 conserved protein (COG2071) K09166 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002084 277.0
SHD2_k127_6121781_5 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004111 279.0
SHD2_k127_6121781_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001227 269.0
SHD2_k127_6121781_7 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007786 272.0
SHD2_k127_6121781_8 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001213 256.0
SHD2_k127_6121781_9 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003604 270.0
SHD2_k127_6318027_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008552 561.0
SHD2_k127_6318027_1 PFAM Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 312.0
SHD2_k127_6318027_10 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000003786 89.0
SHD2_k127_6318027_11 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000001551 65.0
SHD2_k127_6318027_12 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000001161 53.0
SHD2_k127_6318027_13 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0007678 48.0
SHD2_k127_6318027_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009191 291.0
SHD2_k127_6318027_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003322 299.0
SHD2_k127_6318027_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000224 227.0
SHD2_k127_6318027_5 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 0.000000000000000000000000000000131 127.0
SHD2_k127_6318027_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000001194 103.0
SHD2_k127_6318027_7 Polymer-forming cytoskeletal - - - 0.00000000000000000001296 105.0
SHD2_k127_6318027_8 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.0000000000000006475 88.0
SHD2_k127_6318027_9 ATP synthase alpha/beta chain, C terminal domain - - - 0.0000000000000007239 86.0
SHD2_k127_63442_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 426.0
SHD2_k127_63442_1 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007443 379.0
SHD2_k127_63442_2 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 326.0
SHD2_k127_63442_3 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 295.0
SHD2_k127_63442_4 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000002069 222.0
SHD2_k127_63442_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000005952 229.0
SHD2_k127_63442_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000001629 174.0
SHD2_k127_63442_7 PQQ enzyme repeat - - - 0.000000000000004743 89.0
SHD2_k127_6347097_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 6.689e-307 953.0
SHD2_k127_6347097_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 2.26e-219 690.0
SHD2_k127_6347097_10 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 343.0
SHD2_k127_6347097_11 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007421 339.0
SHD2_k127_6347097_12 virion core protein (lumpy skin disease virus) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 343.0
SHD2_k127_6347097_13 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 315.0
SHD2_k127_6347097_14 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000988 277.0
SHD2_k127_6347097_15 Domain of unknown function (DUF4010) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007169 286.0
SHD2_k127_6347097_16 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003745 278.0
SHD2_k127_6347097_17 tRNA wobble cytosine modification - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005583 294.0
SHD2_k127_6347097_18 cyclic nucleotide binding K10914 - - 0.000000000000000000000000000000000000000000000001742 178.0
SHD2_k127_6347097_19 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.0000000000000000000000000000000000000000000008028 183.0
SHD2_k127_6347097_2 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 610.0
SHD2_k127_6347097_20 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000002479 187.0
SHD2_k127_6347097_21 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000202 130.0
SHD2_k127_6347097_22 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.000000000000000000000000003485 116.0
SHD2_k127_6347097_23 Peptidase family M28 - - - 0.00000000000000000000000002451 126.0
SHD2_k127_6347097_24 Radical SAM K01012 - 2.8.1.6 0.00000000000000005954 94.0
SHD2_k127_6347097_25 Cbs domain K04767 - - 0.000000000000001676 82.0
SHD2_k127_6347097_26 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000296 89.0
SHD2_k127_6347097_27 Nitroreductase - - - 0.0000000000001212 80.0
SHD2_k127_6347097_28 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000003677 83.0
SHD2_k127_6347097_29 Domain of unknown function (DU1801) - - - 0.00000000007233 63.0
SHD2_k127_6347097_3 Belongs to the RtcB family K14415,K18148 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 606.0
SHD2_k127_6347097_30 helix_turn_helix, Lux Regulon - - - 0.000000008673 68.0
SHD2_k127_6347097_31 response regulator K10943 - - 0.000002003 55.0
SHD2_k127_6347097_4 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 594.0
SHD2_k127_6347097_5 Nickel-dependent hydrogenase K00436 - 1.12.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005618 572.0
SHD2_k127_6347097_6 Leukotriene A-4 hydrolase K01254 GO:0003674,GO:0003824,GO:0004177,GO:0004301,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016801,GO:0016803,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 515.0
SHD2_k127_6347097_7 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 486.0
SHD2_k127_6347097_8 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K16950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 398.0
SHD2_k127_6347097_9 coenzyme F420 hydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 368.0
SHD2_k127_6347619_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009289 317.0
SHD2_k127_6347619_1 amino acid K03294,K13868 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009437 296.0
SHD2_k127_6347619_2 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000002417 258.0
SHD2_k127_6374559_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.606e-227 715.0
SHD2_k127_6374559_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000352 603.0
SHD2_k127_6374559_10 Polysaccharide lyase family 4, domain II - - - 0.000000000000000000000000000000000000000000000000003016 187.0
SHD2_k127_6374559_11 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000001359 140.0
SHD2_k127_6374559_12 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000005774 130.0
SHD2_k127_6374559_13 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.00000000000000000000000005935 114.0
SHD2_k127_6374559_14 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000005237 120.0
SHD2_k127_6374559_15 protein histidine kinase activity K06375 - - 0.00000000000000000000000105 112.0
SHD2_k127_6374559_16 Rhodanese Homology Domain - - - 0.00000000000000000000003837 103.0
SHD2_k127_6374559_17 Cytochrome c K17223 - - 0.00000000000143 80.0
SHD2_k127_6374559_18 Cytochrome c K02305,K07152 - - 0.00000000008803 75.0
SHD2_k127_6374559_19 VanZ like family - - - 0.00000000138 70.0
SHD2_k127_6374559_2 Catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 591.0
SHD2_k127_6374559_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 578.0
SHD2_k127_6374559_4 TGS domain K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 458.0
SHD2_k127_6374559_5 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 407.0
SHD2_k127_6374559_6 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008124 367.0
SHD2_k127_6374559_7 Cytochrome b(N-terminal)/b6/petB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003882 282.0
SHD2_k127_6374559_8 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000002569 259.0
SHD2_k127_6374559_9 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000000005407 218.0
SHD2_k127_6388410_0 B12 binding domain - - - 1.16e-254 793.0
SHD2_k127_6388410_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 300.0
SHD2_k127_6388410_2 serine-type endopeptidase activity K08372 - - 0.000000000000000000000000000000000000000000000000000000000000000004504 241.0
SHD2_k127_6388410_3 STAS domain K04749 - - 0.000000000000000000000000000000002828 132.0
SHD2_k127_6388410_4 Zn peptidase - - - 0.0000000000000000000000000007368 130.0
SHD2_k127_6388410_5 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000008975 108.0
SHD2_k127_6388410_6 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000001517 98.0
SHD2_k127_6388410_7 Glutaredoxin K03676 - - 0.0000002563 53.0
SHD2_k127_6388410_8 CAAX protease self-immunity K01266,K07052 - 3.4.11.19 0.0009346 50.0
SHD2_k127_6396803_0 PFAM short-chain dehydrogenase reductase SDR K15314 - - 0.0 1037.0
SHD2_k127_6396803_1 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005752 268.0
SHD2_k127_6396803_2 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.000000000000000000000000003553 128.0
SHD2_k127_6408741_0 response regulator - - - 6.081e-200 634.0
SHD2_k127_6408741_1 HAMP domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 496.0
SHD2_k127_6408741_2 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000000000000005285 175.0
SHD2_k127_6408741_3 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000009533 63.0
SHD2_k127_6473950_0 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000005158 269.0
SHD2_k127_6473950_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000001033 189.0
SHD2_k127_6473950_2 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000007571 130.0
SHD2_k127_6473950_3 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.00000000000000000000000000000513 119.0
SHD2_k127_6478315_0 PA domain - - - 0.0 1055.0
SHD2_k127_6478315_1 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 612.0
SHD2_k127_6478315_10 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 349.0
SHD2_k127_6478315_11 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 355.0
SHD2_k127_6478315_12 PFAM Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 331.0
SHD2_k127_6478315_13 PFAM Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005567 268.0
SHD2_k127_6478315_15 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000004909 218.0
SHD2_k127_6478315_16 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000001024 210.0
SHD2_k127_6478315_17 tRNA pseudouridine synthase K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000007411 224.0
SHD2_k127_6478315_18 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000003018 195.0
SHD2_k127_6478315_19 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.00000000000000000000000000000000000002822 159.0
SHD2_k127_6478315_2 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003346 536.0
SHD2_k127_6478315_20 oxidation-reduction process - - - 0.00000000000000000000000000000000000003271 153.0
SHD2_k127_6478315_21 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000002491 131.0
SHD2_k127_6478315_22 Smr domain - - - 0.000000000000000000000004219 105.0
SHD2_k127_6478315_23 Protein of unknown function, DUF255 - - - 0.00000000000000000003847 106.0
SHD2_k127_6478315_24 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.00000000000000002117 96.0
SHD2_k127_6478315_25 Virulence activator alpha C-term - - - 0.000000000000001142 85.0
SHD2_k127_6478315_26 Putative phosphatase (DUF442) - - - 0.00000000000000215 83.0
SHD2_k127_6478315_27 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000009146 72.0
SHD2_k127_6478315_28 response to oxidative stress - - - 0.000000001215 65.0
SHD2_k127_6478315_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 507.0
SHD2_k127_6478315_30 Nucleotidyl transferase - - - 0.000007497 58.0
SHD2_k127_6478315_4 Mur ligase family, catalytic domain K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 477.0
SHD2_k127_6478315_5 Aldehyde dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 461.0
SHD2_k127_6478315_6 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004658 424.0
SHD2_k127_6478315_7 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 451.0
SHD2_k127_6478315_8 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 356.0
SHD2_k127_6478315_9 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 345.0
SHD2_k127_6490376_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.638e-255 801.0
SHD2_k127_6490376_1 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008245 540.0
SHD2_k127_6490376_10 Predicted membrane protein (DUF2232) - - - 0.0001139 54.0
SHD2_k127_6490376_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000008828 231.0
SHD2_k127_6490376_3 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000296 184.0
SHD2_k127_6490376_4 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000001489 169.0
SHD2_k127_6490376_5 Binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000002553 137.0
SHD2_k127_6490376_6 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000001392 102.0
SHD2_k127_6490376_7 Reductase C-terminal K05297 - 1.18.1.1 0.00000000000000001338 83.0
SHD2_k127_6490376_8 Membrane - - - 0.000000000000003189 89.0
SHD2_k127_6490376_9 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000001473 77.0
SHD2_k127_6520497_0 DNA photolyase domain protein K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 359.0
SHD2_k127_6520497_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 324.0
SHD2_k127_6520497_10 Ferric uptake regulator family K03711 - - 0.000000000000000000000000000000000006939 141.0
SHD2_k127_6520497_11 transferase activity, transferring glycosyl groups K07011 - - 0.000000000000000000000000000000003963 143.0
SHD2_k127_6520497_12 membrane K08972 - - 0.0000000000000000000000000000004601 126.0
SHD2_k127_6520497_13 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000001464 123.0
SHD2_k127_6520497_15 amine dehydrogenase activity - - - 0.000000000002215 80.0
SHD2_k127_6520497_16 Uncharacterized conserved protein (DUF2304) K09153 - - 0.0000002764 62.0
SHD2_k127_6520497_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 334.0
SHD2_k127_6520497_3 NeuB family K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005585 327.0
SHD2_k127_6520497_4 involved in cell wall biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000008768 241.0
SHD2_k127_6520497_5 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000001215 220.0
SHD2_k127_6520497_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000003136 230.0
SHD2_k127_6520497_7 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000003401 214.0
SHD2_k127_6520497_8 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000002485 167.0
SHD2_k127_6520497_9 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000009676 159.0
SHD2_k127_6620036_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004993 606.0
SHD2_k127_6620036_1 Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 454.0
SHD2_k127_6620036_2 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 346.0
SHD2_k127_6620036_3 Cytochrome c assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000277 215.0
SHD2_k127_6620036_4 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.00000000000000000000000000000000000000000000008773 187.0
SHD2_k127_6620036_5 PFAM ABC transporter related K02193 - 3.6.3.41 0.000000000000000000000000000000000000000006695 161.0
SHD2_k127_6620036_6 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000001632 132.0
SHD2_k127_6620036_7 protein conserved in bacteria K09778 - - 0.0000000000000000000000000000002676 131.0
SHD2_k127_6620036_8 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000003358 87.0
SHD2_k127_6655961_0 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 490.0
SHD2_k127_6655961_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 476.0
SHD2_k127_6655961_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000003531 59.0
SHD2_k127_6655961_2 FAD linked oxidases, C-terminal domain K00104,K18930 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008818 406.0
SHD2_k127_6655961_3 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001062 248.0
SHD2_k127_6655961_4 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042,K18121 - 1.1.1.31,1.1.1.60,1.1.1.79 0.0000000000000000000000000000000000000000000000001737 187.0
SHD2_k127_6655961_5 AI-2E family transporter - - - 0.0000000000000000000000000000001422 138.0
SHD2_k127_6655961_6 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000009661 114.0
SHD2_k127_6655961_7 phosphorelay signal transduction system - - - 0.000000000000000000000001426 116.0
SHD2_k127_6655961_8 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000003564 98.0
SHD2_k127_6655961_9 Polysaccharide biosynthesis protein - - - 0.0000000000000004304 78.0
SHD2_k127_6656837_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 470.0
SHD2_k127_6656837_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000005349 282.0
SHD2_k127_6656837_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000004415 228.0
SHD2_k127_6685040_0 Glutamate synthase central domain K00265,K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 442.0
SHD2_k127_6685040_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 426.0
SHD2_k127_6685040_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 335.0
SHD2_k127_6685040_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 319.0
SHD2_k127_6685040_4 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001355 271.0
SHD2_k127_6685040_5 microcin C7 resistance K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000000000000000000004013 249.0
SHD2_k127_6685040_6 STAS domain K04749 - - 0.00000000000000000005351 94.0
SHD2_k127_6747714_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 561.0
SHD2_k127_6747714_1 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 471.0
SHD2_k127_6747714_10 formate dehydrogenase (NAD+) activity K00336,K18006 - 1.12.1.2,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 336.0
SHD2_k127_6747714_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006855 325.0
SHD2_k127_6747714_12 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000002876 252.0
SHD2_k127_6747714_13 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000003396 235.0
SHD2_k127_6747714_14 TIGRFAM 3-oxoacyl-(acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000003897 222.0
SHD2_k127_6747714_15 Tetratricopeptide repeats - - - 0.00000000000000000000000000000000000000000000000000000002635 225.0
SHD2_k127_6747714_16 Papain-like cysteine protease AvrRpt2 - - - 0.00000000000000000000000000000000000000000000000000000006634 203.0
SHD2_k127_6747714_17 Domain of unknown function (DUF3473) - - - 0.000000000000000000000000000000000000000000000000009776 191.0
SHD2_k127_6747714_18 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.00000000000000000000000000000000000000000000000005601 195.0
SHD2_k127_6747714_19 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000227 180.0
SHD2_k127_6747714_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 462.0
SHD2_k127_6747714_20 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.000000000000000000000000000000000000000000004368 186.0
SHD2_k127_6747714_21 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.00000000000000000000000000000000000000001447 156.0
SHD2_k127_6747714_22 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.0000000000000000000000000000000000000001027 175.0
SHD2_k127_6747714_23 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000001965 168.0
SHD2_k127_6747714_24 2 iron, 2 sulfur cluster binding K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000004721 160.0
SHD2_k127_6747714_25 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000006249 157.0
SHD2_k127_6747714_26 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.000000000000000000000000000354 123.0
SHD2_k127_6747714_28 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000009462 123.0
SHD2_k127_6747714_29 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.00000000000000000000002724 111.0
SHD2_k127_6747714_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 457.0
SHD2_k127_6747714_30 protein-disulfide reductase activity - - - 0.0000000000000000000001172 104.0
SHD2_k127_6747714_31 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000004484 100.0
SHD2_k127_6747714_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000001177 102.0
SHD2_k127_6747714_33 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000001296 87.0
SHD2_k127_6747714_34 Haloacid dehalogenase-like hydrolase K07025,K20866 - 3.1.3.10 0.000000000000000004071 99.0
SHD2_k127_6747714_35 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000002379 96.0
SHD2_k127_6747714_36 Domain of unknown function (DUF309) K09763 - - 0.00000000000001937 83.0
SHD2_k127_6747714_37 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000001901 58.0
SHD2_k127_6747714_38 Histidine kinase - - - 0.00017 53.0
SHD2_k127_6747714_39 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0001952 50.0
SHD2_k127_6747714_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 450.0
SHD2_k127_6747714_5 quinone binding K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005588 363.0
SHD2_k127_6747714_6 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 351.0
SHD2_k127_6747714_7 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 316.0
SHD2_k127_6747714_8 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 314.0
SHD2_k127_6747714_9 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 320.0
SHD2_k127_6772616_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 539.0
SHD2_k127_6772616_1 imidazolonepropionase activity K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 385.0
SHD2_k127_6772616_2 FAD linked oxidase domain protein K00103,K16653 GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576 1.1.3.8,1.1.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003155 293.0
SHD2_k127_6772616_3 imidazolonepropionase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002062 282.0
SHD2_k127_6772616_4 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000002564 235.0
SHD2_k127_6772616_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000001118 162.0
SHD2_k127_6772616_6 polysaccharide deacetylase - - - 0.00000000000005704 80.0
SHD2_k127_6789913_0 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000003687 236.0
SHD2_k127_6789913_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000003217 201.0
SHD2_k127_6789913_2 membrane-fusion protein - - - 0.000000000000000000000000000000000000000000000001093 192.0
SHD2_k127_6789913_3 Outer membrane efflux protein - - - 0.00002218 57.0
SHD2_k127_6801220_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000704 163.0
SHD2_k127_6801220_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000001096 145.0
SHD2_k127_6801220_2 MacB-like periplasmic core domain K02004 - - 0.000004904 51.0
SHD2_k127_6816547_0 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 558.0
SHD2_k127_6816547_1 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 477.0
SHD2_k127_6816547_2 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 428.0
SHD2_k127_6816547_3 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 331.0
SHD2_k127_6816547_4 Dna alkylation repair - - - 0.0000000000000000000000000000000000000000000000000000000000000009376 227.0
SHD2_k127_6816547_5 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000000000001016 211.0
SHD2_k127_6816547_6 - - - - 0.0000000000000000000000000000000000000000000002039 173.0
SHD2_k127_6849245_0 Ribosomal protein S1 K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 591.0
SHD2_k127_6849245_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 485.0
SHD2_k127_6849245_10 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000005248 168.0
SHD2_k127_6849245_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000008517 147.0
SHD2_k127_6849245_12 histone H2A K63-linked ubiquitination K10914 - - 0.0000000000000000000000000000000001327 145.0
SHD2_k127_6849245_13 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000000022 118.0
SHD2_k127_6849245_14 YacP-like NYN domain - - - 0.000001084 56.0
SHD2_k127_6849245_15 - - - - 0.000001792 50.0
SHD2_k127_6849245_16 - - - - 0.0003121 52.0
SHD2_k127_6849245_2 Tryptophanyl-tRNA synthetase K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 389.0
SHD2_k127_6849245_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 321.0
SHD2_k127_6849245_4 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000003283 252.0
SHD2_k127_6849245_5 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000001226 245.0
SHD2_k127_6849245_6 PFAM peptidase U61 LD-carboxypeptidase A K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000000002714 199.0
SHD2_k127_6849245_7 Peptidase family M50 K06402 - - 0.000000000000000000000000000000000000000000000004208 180.0
SHD2_k127_6849245_8 Protein similar to CwfJ C-terminus 1 K19710 GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 2.7.7.53 0.0000000000000000000000000000000000000000000003486 173.0
SHD2_k127_6849245_9 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000001604 181.0
SHD2_k127_6863070_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.425e-233 744.0
SHD2_k127_6863070_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 343.0
SHD2_k127_6863070_2 Belongs to the KdsA family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000587 295.0
SHD2_k127_6863070_3 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000002983 228.0
SHD2_k127_6863070_4 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.000000000000000000000000000000001974 139.0
SHD2_k127_6863070_5 ABC transporter - - - 0.00000000000000027 89.0
SHD2_k127_6888055_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 373.0
SHD2_k127_6888055_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000003755 222.0
SHD2_k127_6888055_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000001891 134.0
SHD2_k127_6888055_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000002002 117.0
SHD2_k127_6888055_4 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000008363 60.0
SHD2_k127_6890405_0 3-beta hydroxysteroid dehydrogenase/isomerase family K10011,K12449 - 1.1.1.305,2.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 465.0
SHD2_k127_6890405_1 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001091 254.0
SHD2_k127_6890405_2 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002693 242.0
SHD2_k127_6890405_3 Two component regulator propeller - - - 0.000000000000000001017 99.0
SHD2_k127_6930097_0 ATP-grasp domain K01905,K22224 - 6.2.1.13 3.926e-220 706.0
SHD2_k127_6930097_1 NapC/NirT cytochrome c family, N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 610.0
SHD2_k127_6930097_10 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004068 263.0
SHD2_k127_6930097_11 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003468 240.0
SHD2_k127_6930097_12 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000138 221.0
SHD2_k127_6930097_13 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000005392 198.0
SHD2_k127_6930097_14 PAS sensor protein - - - 0.000000000000000000000000000000000000000000000000005116 190.0
SHD2_k127_6930097_15 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000001444 166.0
SHD2_k127_6930097_16 Peptidase family U32 K08303 - - 0.00000000000000000000000000000000000000000002978 176.0
SHD2_k127_6930097_17 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000003205 142.0
SHD2_k127_6930097_18 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000000004308 145.0
SHD2_k127_6930097_19 Alpha/beta hydrolase family - - - 0.000000000000000000000000106 115.0
SHD2_k127_6930097_2 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 477.0
SHD2_k127_6930097_20 Pas domain - - - 0.0000000000000000000001286 106.0
SHD2_k127_6930097_21 Helix-turn-helix XRE-family like proteins K21498 - - 0.00000000000000000001332 94.0
SHD2_k127_6930097_22 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000204 63.0
SHD2_k127_6930097_23 MarR family - - - 0.00001653 53.0
SHD2_k127_6930097_24 Domain of unknown function (DUF4388) - - - 0.00003297 58.0
SHD2_k127_6930097_3 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 454.0
SHD2_k127_6930097_4 Enoyl-CoA hydratase/isomerase K01715,K07537 - 4.2.1.100,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 371.0
SHD2_k127_6930097_5 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 333.0
SHD2_k127_6930097_6 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 310.0
SHD2_k127_6930097_7 CBS domain K04767 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008719 284.0
SHD2_k127_6930097_8 peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003808 289.0
SHD2_k127_6930097_9 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000434 284.0
SHD2_k127_7017095_0 Alpha amylase, catalytic domain - - - 4.427e-216 689.0
SHD2_k127_7017095_1 Glycogen debranching enzyme - - - 3.771e-203 636.0
SHD2_k127_7017095_2 translation initiation factor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 376.0
SHD2_k127_7017095_3 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 338.0
SHD2_k127_7017095_4 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 333.0
SHD2_k127_7155423_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 478.0
SHD2_k127_7155423_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 348.0
SHD2_k127_7155423_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K08348 - 1.17.1.9,1.17.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001194 272.0
SHD2_k127_7155423_3 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000004803 259.0
SHD2_k127_7155423_4 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000001677 216.0
SHD2_k127_7155423_5 Regulatory protein MerR - - - 0.00000000000000001497 90.0
SHD2_k127_7178154_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004579 282.0
SHD2_k127_7178154_1 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001055 271.0
SHD2_k127_7178154_2 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000002689 201.0
SHD2_k127_7178154_3 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000003642 195.0
SHD2_k127_7178154_4 Cell wall-active antibiotics response 4TMS YvqF - - - 0.000000000000000000000000000000000000000366 159.0
SHD2_k127_7178154_5 Male sterility protein - - - 0.000000000000002767 91.0
SHD2_k127_7178154_6 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00002918 57.0
SHD2_k127_7178154_7 Fibronectin type III-like domain K05349 - 3.2.1.21 0.00007322 56.0
SHD2_k127_7276280_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 2.878e-255 818.0
SHD2_k127_7276280_1 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 6.656e-252 787.0
SHD2_k127_7276280_10 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000002389 171.0
SHD2_k127_7276280_11 DinB family - - - 0.00000000000000000000000000000000000001686 160.0
SHD2_k127_7276280_12 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000008749 147.0
SHD2_k127_7276280_13 cheY-homologous receiver domain - - - 0.000000000000000000000000000001459 135.0
SHD2_k127_7276280_14 bacterial (prokaryotic) histone like domain K03530 - - 0.00000000000000000000000002271 111.0
SHD2_k127_7276280_15 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.00000000000000000000000138 114.0
SHD2_k127_7276280_16 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.00000000000001911 87.0
SHD2_k127_7276280_17 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.00000000000004008 85.0
SHD2_k127_7276280_18 outer membrane autotransporter barrel domain protein - - - 0.00000000001366 74.0
SHD2_k127_7276280_2 carboxylase K11263 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 497.0
SHD2_k127_7276280_3 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 344.0
SHD2_k127_7276280_4 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 317.0
SHD2_k127_7276280_5 enoyl-CoA hydratase K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000001362 254.0
SHD2_k127_7276280_6 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000003259 237.0
SHD2_k127_7276280_7 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000004484 184.0
SHD2_k127_7276280_8 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000005619 178.0
SHD2_k127_7276280_9 Metallo-beta-lactamase superfamily K02238 - - 0.00000000000000000000000000000000000000000009544 181.0
SHD2_k127_7422121_0 Oligopeptide transporter OPT - - - 7.656e-240 760.0
SHD2_k127_7422121_1 AAA domain K01551 - 3.6.3.16 2.394e-208 666.0
SHD2_k127_7422121_10 coagulation factor 5 8 type - - - 0.000000000000000000000000000000000000000000000000000000001733 216.0
SHD2_k127_7422121_11 TIGRFAM cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000005716 196.0
SHD2_k127_7422121_12 AAA domain - - - 0.0000000000000000000000000000000000000000000001343 188.0
SHD2_k127_7422121_13 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000001372 168.0
SHD2_k127_7422121_14 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000245 164.0
SHD2_k127_7422121_15 Arsenical resistance operon trans-acting repressor ArsD - - - 0.0000000000000000000000000000009128 126.0
SHD2_k127_7422121_16 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.00000000000000000000000003183 115.0
SHD2_k127_7422121_17 Domain of unknown function (DUF3883) - - - 0.000000000000000000000004108 104.0
SHD2_k127_7422121_18 Protein of unknown function (DUF2752) - - - 0.000000000001918 81.0
SHD2_k127_7422121_19 - - - - 0.000000000007848 70.0
SHD2_k127_7422121_2 COG0798 Arsenite efflux pump ACR3 and related K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 494.0
SHD2_k127_7422121_20 ABC transporter K01990 - - 0.00002188 57.0
SHD2_k127_7422121_21 Nickel/cobalt transporter regulator - - - 0.00006736 54.0
SHD2_k127_7422121_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 411.0
SHD2_k127_7422121_4 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008219 362.0
SHD2_k127_7422121_5 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 334.0
SHD2_k127_7422121_6 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 331.0
SHD2_k127_7422121_7 PFAM peptidase T2 asparaginase 2 K01444,K13051 - 3.4.19.5,3.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008632 318.0
SHD2_k127_7422121_8 PFAM NADP oxidoreductase coenzyme F420-dependent K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000001138 256.0
SHD2_k127_7436942_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1047.0
SHD2_k127_7436942_1 4Fe-4S single cluster domain K06937 - - 6.7e-245 772.0
SHD2_k127_7436942_10 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001177 286.0
SHD2_k127_7436942_11 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000003494 265.0
SHD2_k127_7436942_12 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000005369 266.0
SHD2_k127_7436942_13 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000006362 235.0
SHD2_k127_7436942_14 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000003214 231.0
SHD2_k127_7436942_15 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000001149 180.0
SHD2_k127_7436942_16 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000002897 176.0
SHD2_k127_7436942_17 PFAM FAD dependent oxidoreductase K03153 - 1.4.3.19 0.00000000000000000000000000000000000000002536 171.0
SHD2_k127_7436942_18 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000008284 162.0
SHD2_k127_7436942_19 Alpha beta hydrolase - - - 0.000000000000000000000000000000000005226 159.0
SHD2_k127_7436942_2 PFAM tRNA synthetases class I (E and Q), catalytic domain K01886 - 6.1.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 531.0
SHD2_k127_7436942_20 EamA-like transporter family - - - 0.000000000000000000000000000002061 133.0
SHD2_k127_7436942_21 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000001135 131.0
SHD2_k127_7436942_22 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000003683 131.0
SHD2_k127_7436942_23 Tetratricopeptide repeat K05807 - - 0.00000000000000000000001173 113.0
SHD2_k127_7436942_24 related to Ser Thr protein kinases K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.000000000000000000002037 108.0
SHD2_k127_7436942_25 synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000002363 83.0
SHD2_k127_7436942_26 LysM domain - - - 0.00000000007144 73.0
SHD2_k127_7436942_27 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000001871 68.0
SHD2_k127_7436942_28 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000009771 65.0
SHD2_k127_7436942_29 PFAM helix-turn-helix, Fis-type - - - 0.00000005674 59.0
SHD2_k127_7436942_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008418 513.0
SHD2_k127_7436942_30 transcriptional regulator - - - 0.00005265 51.0
SHD2_k127_7436942_4 cysteine synthase K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 414.0
SHD2_k127_7436942_5 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 410.0
SHD2_k127_7436942_6 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 383.0
SHD2_k127_7436942_7 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 357.0
SHD2_k127_7436942_8 PDZ DHR GLGF domain protein K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008952 340.0
SHD2_k127_7436942_9 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004776 292.0
SHD2_k127_7464870_0 receptor K16092 - - 0.0000000000000009898 91.0
SHD2_k127_7486574_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 6.83e-201 639.0
SHD2_k127_7486574_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.321e-195 643.0
SHD2_k127_7486574_2 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 564.0
SHD2_k127_7486574_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 574.0
SHD2_k127_7486574_4 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 365.0
SHD2_k127_7486574_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002506 282.0
SHD2_k127_7486574_6 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000005796 107.0
SHD2_k127_7486574_7 Cupin domain - - - 0.00001999 53.0
SHD2_k127_7507193_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 489.0
SHD2_k127_7507193_1 outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000001248 203.0
SHD2_k127_7507193_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000009296 70.0
SHD2_k127_7510339_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 7.775e-250 791.0
SHD2_k127_7510339_1 PFAM Type II secretion system protein E K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 547.0
SHD2_k127_7510339_10 allophanate hydrolase subunit 1 - - - 0.000000000000000000000000000000000000000942 168.0
SHD2_k127_7510339_11 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000000000004592 166.0
SHD2_k127_7510339_12 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000001429 160.0
SHD2_k127_7510339_13 general secretion pathway protein K02456 - - 0.00000000000000000000000000000006544 130.0
SHD2_k127_7510339_14 peroxiredoxin activity - - - 0.000000000000000000002756 110.0
SHD2_k127_7510339_15 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000003712 83.0
SHD2_k127_7510339_16 general secretion pathway protein K02456,K02650 - - 0.0000000000000003721 90.0
SHD2_k127_7510339_2 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009711 359.0
SHD2_k127_7510339_3 4Fe-4S single cluster domain of Ferredoxin I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 313.0
SHD2_k127_7510339_4 Type ii and iii secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 322.0
SHD2_k127_7510339_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003677 284.0
SHD2_k127_7510339_6 Insulinase (Peptidase family M16) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000001663 241.0
SHD2_k127_7510339_7 Allophanate hydrolase subunit 2 K06350 - - 0.000000000000000000000000000000000000000000000000000000001118 216.0
SHD2_k127_7510339_8 LamB/YcsF family K07160 - - 0.0000000000000000000000000000000000000000000000000000001484 215.0
SHD2_k127_7510339_9 beta-lactamase - - - 0.00000000000000000000000000000000000000000001013 178.0
SHD2_k127_7511591_0 Sortilin, neurotensin receptor 3, - - - 0.0 1264.0
SHD2_k127_7511591_1 Peptidase dimerisation domain - - - 3.245e-197 636.0
SHD2_k127_7511591_2 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 595.0
SHD2_k127_7511591_3 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 351.0
SHD2_k127_7511591_4 Forkhead associated domain - - - 0.0000000000000000000000000000000000000000000000000000000009773 218.0
SHD2_k127_7511591_5 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000005237 196.0
SHD2_k127_7511591_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000002931 122.0
SHD2_k127_7511591_7 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000002265 74.0
SHD2_k127_7535339_0 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 1.454e-246 786.0
SHD2_k127_7535339_1 cellulose binding - - - 4.273e-203 655.0
SHD2_k127_7535339_2 Sulfatase K01130 - 3.1.6.1 1.965e-195 613.0
SHD2_k127_7535339_3 unsaturated fatty acid biosynthetic process K04712 - 1.14.18.5,1.14.19.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 420.0
SHD2_k127_7535339_4 arylamine N-acetyltransferase activity K00675 - 2.3.1.118 0.000000000000000000000000000000000000000000000000000000000000000007958 252.0
SHD2_k127_7535339_5 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000004999 180.0
SHD2_k127_7535339_6 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000002367 126.0
SHD2_k127_7535339_7 - - - - 0.00000000000000251 89.0
SHD2_k127_7548866_0 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 313.0
SHD2_k127_7548866_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000008756 216.0
SHD2_k127_7548866_2 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000002673 154.0
SHD2_k127_7548866_3 Sigma factor PP2C-like phosphatases - - - 0.0000000000000000000000000000000000002155 157.0
SHD2_k127_7548866_4 - - - - 0.0000000000007562 72.0
SHD2_k127_7562966_0 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.0 1251.0
SHD2_k127_7562966_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 452.0
SHD2_k127_7562966_10 Involved in the tonB-independent uptake of proteins - GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046397,GO:0071704,GO:0072329,GO:1901575 - 0.000000000000000001944 101.0
SHD2_k127_7562966_2 Participates in initiation and elongation during chromosome replication K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 366.0
SHD2_k127_7562966_3 ABC transporter permease K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002911 277.0
SHD2_k127_7562966_4 PFAM Mammalian cell entry related domain protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002111 258.0
SHD2_k127_7562966_5 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002939 261.0
SHD2_k127_7562966_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001203 249.0
SHD2_k127_7562966_7 pfam abc K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000148 243.0
SHD2_k127_7562966_8 RNA polymerase, sigma-24 subunit, ECF subfamily K02405 - - 0.00000000000000000000000000000000000000000000000000000000000007444 218.0
SHD2_k127_7562966_9 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000009245 181.0
SHD2_k127_7595049_0 Belongs to the ClpA ClpB family K03696 - - 1.627e-284 895.0
SHD2_k127_7595049_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 538.0
SHD2_k127_7595049_10 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000003671 156.0
SHD2_k127_7595049_11 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000007206 79.0
SHD2_k127_7595049_12 Outer membrane protein (OmpH-like) K06142 - - 0.00000001686 64.0
SHD2_k127_7595049_2 Surface antigen variable number K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 399.0
SHD2_k127_7595049_3 Elongation factor G, domain IV K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 340.0
SHD2_k127_7595049_4 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 341.0
SHD2_k127_7595049_5 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000004906 271.0
SHD2_k127_7595049_6 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000003231 256.0
SHD2_k127_7595049_7 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000000000000001542 210.0
SHD2_k127_7595049_8 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372,K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000000000000000000000007882 177.0
SHD2_k127_7595049_9 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000000000000003803 177.0
SHD2_k127_7608636_0 Prolyl oligopeptidase K01322 - 3.4.21.26 9.505e-234 742.0
SHD2_k127_7608636_1 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 618.0
SHD2_k127_7608636_10 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000001875 239.0
SHD2_k127_7608636_11 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000006788 184.0
SHD2_k127_7608636_12 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000002171 159.0
SHD2_k127_7608636_13 Psort location Cytoplasmic, score 8.96 - - - 0.000000000000000000000000000000000000004576 147.0
SHD2_k127_7608636_14 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.0000000000000000000000000000001415 139.0
SHD2_k127_7608636_15 Protein kinase domain K12132 - 2.7.11.1 0.000001483 52.0
SHD2_k127_7608636_16 GMP synthase-glutamine amidotransferase - - - 0.0001692 53.0
SHD2_k127_7608636_2 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 423.0
SHD2_k127_7608636_3 ABC transporter C-terminal domain K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 392.0
SHD2_k127_7608636_4 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 368.0
SHD2_k127_7608636_5 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 386.0
SHD2_k127_7608636_6 Patatin-like phospholipase K06900 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 340.0
SHD2_k127_7608636_7 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006336 313.0
SHD2_k127_7608636_8 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 302.0
SHD2_k127_7608636_9 short chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001555 282.0
SHD2_k127_7647739_0 TIGRFAM NHLM bacteriocin system ABC transporter, peptidase ATP-binding protein - - - 2.348e-256 810.0
SHD2_k127_7647739_1 ABC transporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008426 642.0
SHD2_k127_7647739_10 histone H2A K63-linked ubiquitination K10914 - - 0.00000000000000000000000000001035 130.0
SHD2_k127_7647739_11 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000000000001387 119.0
SHD2_k127_7647739_12 Outer membrane efflux protein - - - 0.00000000000000000000001435 117.0
SHD2_k127_7647739_13 transporter antisigma-factor antagonist STAS K04749 - - 0.000000000000000000000182 111.0
SHD2_k127_7647739_14 phosphatase activity K07025,K20862 - 3.1.3.102,3.1.3.104 0.00000000000000007328 95.0
SHD2_k127_7647739_15 anti-sigma regulatory factor, serine threonine protein kinase K04757 - 2.7.11.1 0.0000000000000001074 96.0
SHD2_k127_7647739_16 FHA domain containing protein - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000007037 83.0
SHD2_k127_7647739_17 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000004708 69.0
SHD2_k127_7647739_18 membrane K07058 - - 0.000000001446 71.0
SHD2_k127_7647739_19 Nitrile hydratase - - - 0.0000003484 56.0
SHD2_k127_7647739_2 Lanthionine synthetase C-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 485.0
SHD2_k127_7647739_20 Nitrile hydratase - - - 0.00001236 56.0
SHD2_k127_7647739_21 membrane - GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0043021,GO:0043024,GO:0044464,GO:0044877,GO:0060187,GO:0071944 - 0.00001405 51.0
SHD2_k127_7647739_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007014 316.0
SHD2_k127_7647739_4 FHA domain K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005751 299.0
SHD2_k127_7647739_5 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000831 277.0
SHD2_k127_7647739_6 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000005365 238.0
SHD2_k127_7647739_7 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000001813 204.0
SHD2_k127_7647739_8 PFAM Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000641 176.0
SHD2_k127_7647739_9 Outer membrane efflux protein - - - 0.0000000000000000000000000000006098 141.0
SHD2_k127_7722023_0 Insulinase (Peptidase family M16) K07263 - - 0.0 1189.0
SHD2_k127_7722023_1 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 1.768e-253 798.0
SHD2_k127_7722023_10 PFAM homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000699 278.0
SHD2_k127_7722023_11 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000009909 224.0
SHD2_k127_7722023_12 SUF system FeS assembly protein K04488 - - 0.0000000000000000000000000000000000000000000004093 187.0
SHD2_k127_7722023_13 Transcriptional regulator - - - 0.0000000000000000000000000000000000001366 146.0
SHD2_k127_7722023_14 metal-sulfur cluster biosynthetic enzyme K02612 - - 0.0000000000000000000000000000002989 134.0
SHD2_k127_7722023_15 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000004182 133.0
SHD2_k127_7722023_16 - - - - 0.00000000000000000004606 105.0
SHD2_k127_7722023_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 571.0
SHD2_k127_7722023_3 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 478.0
SHD2_k127_7722023_4 Sodium:solute symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 404.0
SHD2_k127_7722023_5 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 394.0
SHD2_k127_7722023_6 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 383.0
SHD2_k127_7722023_7 ATP-dependent DNA helicase activity K01144,K07464,K16898 - 3.1.11.5,3.1.12.1,3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009764 379.0
SHD2_k127_7722023_8 Uncharacterized protein family (UPF0051) K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006296 362.0
SHD2_k127_7722023_9 long-chain fatty acid transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 293.0
SHD2_k127_7730012_0 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 415.0
SHD2_k127_7730012_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000002727 226.0
SHD2_k127_7730012_2 Protein kinase domain - - - 0.000000000000000000000000000000000000007442 155.0
SHD2_k127_7730012_3 PFAM YdjC family protein K03478 - 3.5.1.105 0.000000000000000000000000000004842 136.0
SHD2_k127_7730012_4 Mannosyltransferase (PIG-V) - - - 0.0000000000000000003271 100.0
SHD2_k127_7730012_5 Methyltransferase small domain - - - 0.00000000002907 76.0
SHD2_k127_7770624_0 Urocanase C-terminal domain K01712 - 4.2.1.49 5.747e-240 756.0
SHD2_k127_7770624_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.427e-196 654.0
SHD2_k127_7770624_10 anion-transporting ATPase - - - 0.0000000000000000000000000000000000006791 160.0
SHD2_k127_7770624_11 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000001205 131.0
SHD2_k127_7770624_12 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000004773 147.0
SHD2_k127_7770624_14 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000001937 109.0
SHD2_k127_7770624_15 PFAM peptidase M22 glycoprotease K14742 - - 0.000000002596 66.0
SHD2_k127_7770624_16 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.00008227 55.0
SHD2_k127_7770624_17 PFAM PHA accumulation regulator DNA-binding protein - - - 0.0001153 52.0
SHD2_k127_7770624_18 Protein of unknown function (DUF465) - - - 0.000838 46.0
SHD2_k127_7770624_2 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 507.0
SHD2_k127_7770624_3 PFAM phospholipid glycerol acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002565 297.0
SHD2_k127_7770624_4 PFAM Patatin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003502 272.0
SHD2_k127_7770624_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000002181 216.0
SHD2_k127_7770624_6 NAD dependent epimerase/dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000006299 220.0
SHD2_k127_7770624_7 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000008278 212.0
SHD2_k127_7770624_8 beta-N-acetylhexosaminidase K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000002696 183.0
SHD2_k127_7770624_9 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 0.00000000000000000000000000000000000008985 166.0
SHD2_k127_7775665_0 PFAM peptidase K01284,K01414 - 3.4.15.5,3.4.24.70 5.203e-265 834.0
SHD2_k127_7775665_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 488.0
SHD2_k127_7775665_10 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 317.0
SHD2_k127_7775665_11 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000001561 269.0
SHD2_k127_7775665_12 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000000000000000000000000000000000008742 227.0
SHD2_k127_7775665_13 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000002778 194.0
SHD2_k127_7775665_14 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000004176 197.0
SHD2_k127_7775665_15 PFAM OsmC family protein - - - 0.00000000000000000000000000000000000000009651 158.0
SHD2_k127_7775665_16 (twin-arginine translocation) pathway signal - - - 0.0000000000000000000000000000000008041 138.0
SHD2_k127_7775665_17 - - - - 0.000000000000000005517 96.0
SHD2_k127_7775665_18 - - - - 0.000000000003905 72.0
SHD2_k127_7775665_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 447.0
SHD2_k127_7775665_20 - - - - 0.0002483 50.0
SHD2_k127_7775665_21 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0006926 49.0
SHD2_k127_7775665_3 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 432.0
SHD2_k127_7775665_4 Belongs to the PstS family K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 396.0
SHD2_k127_7775665_5 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 373.0
SHD2_k127_7775665_6 COG0451 Nucleoside-diphosphate-sugar epimerases K05281 - 1.3.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 331.0
SHD2_k127_7775665_7 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 326.0
SHD2_k127_7775665_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 303.0
SHD2_k127_7775665_9 Phosphate transport system permease protein PstA K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 315.0
SHD2_k127_7829199_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1254.0
SHD2_k127_7829199_1 DNA topoisomerase K02470,K02622 - 5.99.1.3 1.756e-216 681.0
SHD2_k127_7829199_10 diguanylate cyclase activity K13069 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000002832 224.0
SHD2_k127_7829199_11 metallopeptidase activity K01993,K13408,K16922 - - 0.00000000000000000000000000000000000000000000000000000000000005529 240.0
SHD2_k127_7829199_12 Amidohydrolase family K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000004676 207.0
SHD2_k127_7829199_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.0000000000000000000000000000000000000000000000000000002273 220.0
SHD2_k127_7829199_14 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000004526 185.0
SHD2_k127_7829199_15 NlpC/P60 family - - - 0.000000000000000000000000000000000000000006734 175.0
SHD2_k127_7829199_16 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000239 161.0
SHD2_k127_7829199_17 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000001286 168.0
SHD2_k127_7829199_18 Histidine kinase - - - 0.00000000000000000000000000001588 134.0
SHD2_k127_7829199_19 PFAM Uncharacterised protein family (UPF0227) K07000 - - 0.0000000000000000001998 99.0
SHD2_k127_7829199_2 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 595.0
SHD2_k127_7829199_20 Domain of unknown function (DUF4440) - - - 0.00000000000000000125 93.0
SHD2_k127_7829199_21 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000001367 97.0
SHD2_k127_7829199_22 - - - - 0.0000000000000000421 89.0
SHD2_k127_7829199_23 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000009694 92.0
SHD2_k127_7829199_24 STAS domain - - - 0.00000000000003314 79.0
SHD2_k127_7829199_25 PFAM Redoxin - - - 0.0002068 51.0
SHD2_k127_7829199_3 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009637 358.0
SHD2_k127_7829199_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 326.0
SHD2_k127_7829199_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 297.0
SHD2_k127_7829199_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009181 301.0
SHD2_k127_7829199_7 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000341 273.0
SHD2_k127_7829199_8 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003267 287.0
SHD2_k127_7829199_9 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000001207 242.0
SHD2_k127_7840623_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 2.569e-214 681.0
SHD2_k127_7840623_1 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007591 512.0
SHD2_k127_7840623_10 Lipid A biosynthesis K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000006475 169.0
SHD2_k127_7840623_11 Two component regulator propeller - - - 0.000000000000000000000000000000000001228 160.0
SHD2_k127_7840623_12 PFAM glycosyl transferase family 9 K02841 - - 0.000000000000000000000000000000000003928 150.0
SHD2_k127_7840623_13 Sigma-70 region 2 K03088 - - 0.000000000000000000000007285 111.0
SHD2_k127_7840623_14 Protein of unknown function (DUF3108) - - - 0.00000000000000000000008457 111.0
SHD2_k127_7840623_15 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000103 105.0
SHD2_k127_7840623_16 Regulatory protein, FmdB family - - - 0.00000000000000001955 86.0
SHD2_k127_7840623_17 Response regulator, receiver - - - 0.0000005211 57.0
SHD2_k127_7840623_2 Type II secretion system (T2SS), protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 452.0
SHD2_k127_7840623_3 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003747 437.0
SHD2_k127_7840623_4 phosphorelay sensor kinase activity K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001915 286.0
SHD2_k127_7840623_5 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004813 284.0
SHD2_k127_7840623_6 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000002996 233.0
SHD2_k127_7840623_7 PFAM HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000006065 209.0
SHD2_k127_7840623_8 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 0.0000000000000000000000000000000000000000000000000001213 200.0
SHD2_k127_7840623_9 General secretory system II, protein E domain protein K02652 - - 0.00000000000000000000000000000000000000000000000001586 201.0
SHD2_k127_7928436_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.237e-288 912.0
SHD2_k127_7928436_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.035e-241 770.0
SHD2_k127_7928436_10 Transmembrane and - - - 0.00000000000000000000000000000000009843 152.0
SHD2_k127_7928436_11 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000004706 105.0
SHD2_k127_7928436_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117,K03646 - - 0.0000000000001062 75.0
SHD2_k127_7928436_13 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000005579 69.0
SHD2_k127_7928436_14 Stage II sporulation protein - - - 0.0000001367 64.0
SHD2_k127_7928436_15 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00006085 53.0
SHD2_k127_7928436_16 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0008483 42.0
SHD2_k127_7928436_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 4.752e-218 688.0
SHD2_k127_7928436_3 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008898 413.0
SHD2_k127_7928436_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 367.0
SHD2_k127_7928436_5 PFAM Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001068 265.0
SHD2_k127_7928436_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001109 261.0
SHD2_k127_7928436_7 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000001033 200.0
SHD2_k127_7928436_8 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000003791 186.0
SHD2_k127_7928436_9 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000001002 172.0
SHD2_k127_7932884_0 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 450.0
SHD2_k127_7932884_1 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 323.0
SHD2_k127_7932884_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000009696 246.0
SHD2_k127_7932884_3 nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000002342 168.0
SHD2_k127_7932884_4 - - - - 0.00000000000000000000000000000000000000000034 173.0
SHD2_k127_7932884_5 - - - - 0.000000000000000000000001046 115.0
SHD2_k127_7932884_6 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000004421 115.0
SHD2_k127_7950964_0 Belongs to the heat shock protein 70 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 606.0
SHD2_k127_7950964_1 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 495.0
SHD2_k127_7950964_10 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000007808 64.0
SHD2_k127_7950964_11 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000001111 65.0
SHD2_k127_7950964_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 395.0
SHD2_k127_7950964_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 387.0
SHD2_k127_7950964_4 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 303.0
SHD2_k127_7950964_5 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000109 263.0
SHD2_k127_7950964_6 EXOIII K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000004678 223.0
SHD2_k127_7950964_7 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000002892 186.0
SHD2_k127_7950964_8 domain, Protein K12685,K16785,K16786,K16787 - - 0.00000000001401 78.0
SHD2_k127_7950964_9 PQ loop repeat K15383 - - 0.0000000001201 68.0
SHD2_k127_8007859_0 DNA Topoisomerase IV K02469 - 5.99.1.3 1.641e-240 764.0
SHD2_k127_8007859_1 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 454.0
SHD2_k127_8007859_2 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 411.0
SHD2_k127_8007859_3 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 335.0
SHD2_k127_8007859_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00375,K05825,K16422,K16423 - 1.1.3.46,2.6.1.103 0.00000000000000000000000000000000000000000000000000000000000000000001985 252.0
SHD2_k127_8007859_5 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.00000000000000000000000000000000000000000000000000000000000001402 223.0
SHD2_k127_8007859_6 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000277 215.0
SHD2_k127_8007859_7 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000004394 199.0
SHD2_k127_8007859_8 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000007751 134.0
SHD2_k127_8034660_0 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 322.0
SHD2_k127_8034660_1 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006463 283.0
SHD2_k127_8034660_2 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000002356 223.0
SHD2_k127_8034660_3 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.0000000000000000000000000000000000000000000000000008463 188.0
SHD2_k127_8034660_4 impB/mucB/samB family K14161 - - 0.00000000000000000000000000000000002944 152.0
SHD2_k127_8034660_5 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000007535 151.0
SHD2_k127_8034660_6 recA bacterial DNA recombination protein - - - 0.0000000000006185 82.0
SHD2_k127_8239080_0 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 1.153e-198 633.0
SHD2_k127_8239080_1 peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 519.0
SHD2_k127_8239080_10 Domain of unknown function (DUF1972) - - - 0.0000000000000003413 81.0
SHD2_k127_8239080_11 DinB superfamily - - - 0.00000000005024 73.0
SHD2_k127_8239080_12 Lipid A 3-O-deacylase (PagL) - - - 0.0001373 54.0
SHD2_k127_8239080_2 Sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 360.0
SHD2_k127_8239080_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 358.0
SHD2_k127_8239080_4 Rhs Element Vgr Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000002601 249.0
SHD2_k127_8239080_5 Cupin domain - - - 0.0000000000000000000000000000000000000000000000003812 179.0
SHD2_k127_8239080_6 PAP2 superfamily C-terminal - - - 0.0000000000000000000000000000000000000000000004795 181.0
SHD2_k127_8239080_7 stage 0 sporulation protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000002502 163.0
SHD2_k127_8239080_8 Hfq protein - - - 0.000000000000000000000000000006465 124.0
SHD2_k127_8239080_9 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000006526 124.0
SHD2_k127_8257239_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 1.31e-292 959.0
SHD2_k127_8257239_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 580.0
SHD2_k127_8257239_10 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 383.0
SHD2_k127_8257239_11 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 351.0
SHD2_k127_8257239_12 4-hydroxyproline epimerase activity K01777,K12658 GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661 5.1.1.4,5.1.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 338.0
SHD2_k127_8257239_13 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 286.0
SHD2_k127_8257239_14 recombinase XerD K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000008048 268.0
SHD2_k127_8257239_15 serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000136 240.0
SHD2_k127_8257239_16 Beta-lactamase - - - 0.0000000000000000000000000000000000000000009676 177.0
SHD2_k127_8257239_17 DinB family - - - 0.00000000000000000000000000000000000003445 149.0
SHD2_k127_8257239_18 Hypothetical methyltransferase - - - 0.000000000000000000000000000000000001359 151.0
SHD2_k127_8257239_19 Poly A polymerase head domain - - - 0.00000000000000000000000000000000006397 152.0
SHD2_k127_8257239_2 GMP synthase C terminal domain K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007542 582.0
SHD2_k127_8257239_20 lytic transglycosylase - - - 0.0000000000000000000000000000000003215 140.0
SHD2_k127_8257239_21 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000007577 114.0
SHD2_k127_8257239_22 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000008191 94.0
SHD2_k127_8257239_23 Permease, YjgP YjgQ - - - 0.0000000000061 68.0
SHD2_k127_8257239_3 Putative Na+/H+ antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007267 587.0
SHD2_k127_8257239_4 S-adenosylmethionine synthetase, C-terminal domain K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 548.0
SHD2_k127_8257239_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 554.0
SHD2_k127_8257239_6 Belongs to the aldehyde dehydrogenase family K22187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 443.0
SHD2_k127_8257239_7 homogentisate 12-dioxygenase K00451 - 1.13.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 406.0
SHD2_k127_8257239_8 dioxygenase K00457,K16421 - 1.13.11.27,1.13.11.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 386.0
SHD2_k127_8257239_9 Belongs to the DapA family K21062 - 3.5.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 377.0
SHD2_k127_857007_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 458.0
SHD2_k127_857007_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 324.0
SHD2_k127_857007_2 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000345 248.0
SHD2_k127_857007_3 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000002126 234.0
SHD2_k127_857007_4 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000005464 123.0