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Overview

ID MAG03384
Name SHD2_bin.9
Sample SMP0083
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Gemmatimonadales
Family Gemmatimonadaceae
Genus UBA4720
Species
Assembly information
Completeness (%) 83.17
Contamination (%) 3.28
GC content (%) 59.0
N50 (bp) 9,473
Genome size (bp) 3,058,178

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2814

Gene name Description KEGG GOs EC E-value Score Sequence
SHD2_k127_103364_0 CobQ CobB MinD ParA nucleotide binding domain K16554,K16692 - - 0.0000000000000000000000000000000000000000000000000000000000000000001276 258.0
SHD2_k127_103364_1 Glycosyltransferase, group 4 family K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000009007 217.0
SHD2_k127_103364_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000005319 152.0
SHD2_k127_103364_3 COG1596 Periplasmic protein involved in polysaccharide export K20988 - - 0.0000000001346 69.0
SHD2_k127_1052924_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 376.0
SHD2_k127_1052924_1 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000005463 223.0
SHD2_k127_1052924_2 PFAM OsmC family protein - - - 0.0000000000000000000000000000000000000000000000000000000001591 206.0
SHD2_k127_1052924_3 copper resistance - - - 0.000000000000000008997 87.0
SHD2_k127_1064981_0 UDP binding domain K00012 - 1.1.1.22 4.079e-195 617.0
SHD2_k127_1064981_1 UDP binding domain K13015 - 1.1.1.136 0.0000000001412 63.0
SHD2_k127_1065648_0 LytB protein K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 574.0
SHD2_k127_1065648_1 lysine 2,3-aminomutase activity K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 385.0
SHD2_k127_1065648_2 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000916 267.0
SHD2_k127_1065648_3 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000005154 190.0
SHD2_k127_1065648_4 LD-carboxypeptidase K01297 - 3.4.17.13 0.0000000000000000000000000000000000000000000000002602 189.0
SHD2_k127_1068743_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 6.249e-214 681.0
SHD2_k127_1068743_1 Protein of unknown function (DUF1343) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 464.0
SHD2_k127_1068743_2 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000003945 235.0
SHD2_k127_1068743_3 Iron-sulphur cluster biosynthesis - - - 0.000000000000000000000000000000000000000000000000001502 188.0
SHD2_k127_1068743_4 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000007036 152.0
SHD2_k127_1076735_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1266.0
SHD2_k127_1076735_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 7.009e-220 688.0
SHD2_k127_1076735_2 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 553.0
SHD2_k127_1076735_3 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 540.0
SHD2_k127_1076735_4 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 540.0
SHD2_k127_1076735_5 Zn peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 361.0
SHD2_k127_1076735_6 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 325.0
SHD2_k127_1076735_7 - - - - 0.00000003456 64.0
SHD2_k127_1085744_0 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 483.0
SHD2_k127_1085744_1 beta-N-acetylglucosaminidase K01197 - 3.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 477.0
SHD2_k127_1085744_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 397.0
SHD2_k127_1085744_3 Phosphoesterase family K01114 - 3.1.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007113 397.0
SHD2_k127_1085744_4 NmrA-like family - - - 0.000000000000000000000000000000000000000000004449 177.0
SHD2_k127_1085744_5 - - - - 0.00000000000000000000000004316 117.0
SHD2_k127_1085744_6 Belongs to the MtfA family K09933 - - 0.00000000000000000000006871 99.0
SHD2_k127_1095657_0 cyclic-guanylate-specific phosphodiesterase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 561.0
SHD2_k127_1095657_1 Conserved TM helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 344.0
SHD2_k127_1095657_2 - - - - 0.00000000000002333 76.0
SHD2_k127_1099985_0 Protein export membrane protein - - - 2.517e-231 723.0
SHD2_k127_1099985_1 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 470.0
SHD2_k127_1099985_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007628 452.0
SHD2_k127_1099985_3 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 370.0
SHD2_k127_1099985_4 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 322.0
SHD2_k127_1099985_5 - - - - 0.0000000000000000000000000000000000162 143.0
SHD2_k127_1101008_0 Protein of unknown function (DUF1254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 498.0
SHD2_k127_1101008_1 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 309.0
SHD2_k127_1101008_2 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000000000000000003105 189.0
SHD2_k127_1101008_3 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000003863 190.0
SHD2_k127_111096_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 576.0
SHD2_k127_111096_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007798 391.0
SHD2_k127_111096_2 Nodulation protein S (NodS) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 311.0
SHD2_k127_111096_3 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000003238 155.0
SHD2_k127_1115030_0 polysaccharide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 302.0
SHD2_k127_1115030_1 ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - 0.0000000000000000000000000000000000000002184 164.0
SHD2_k127_1115030_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000002066 150.0
SHD2_k127_1137638_0 Aldehyde dehydrogenase family K22187 - - 2.646e-274 849.0
SHD2_k127_1137638_1 Bacterial regulatory protein, Fis family - - - 1.155e-213 672.0
SHD2_k127_1137638_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 597.0
SHD2_k127_1137638_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004456 478.0
SHD2_k127_1137638_4 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 332.0
SHD2_k127_1137638_5 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001228 242.0
SHD2_k127_1137638_6 - - - - 0.00000000000000000000000000000000000000000000000001081 188.0
SHD2_k127_1137638_7 Carboxypeptidase regulatory-like domain - - - 0.00000007623 61.0
SHD2_k127_1151402_0 Sortilin, neurotensin receptor 3, - - - 4.992e-315 997.0
SHD2_k127_1151402_1 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 559.0
SHD2_k127_1151402_2 Zn-dependent protease with chaperone function K03799,K06013 - 3.4.24.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 411.0
SHD2_k127_1151402_3 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003447 277.0
SHD2_k127_1151402_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000154 255.0
SHD2_k127_1151402_5 lytic transglycosylase activity - - - 0.0000000000000000000004638 106.0
SHD2_k127_1151402_6 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - 0.00001762 55.0
SHD2_k127_1171922_0 Tetratricopeptide repeat - - - 1.042e-207 658.0
SHD2_k127_1171922_1 aminopeptidase N - - - 0.000000000000000000000000000000000001321 156.0
SHD2_k127_1171922_2 Peptidase family M28 - - - 0.0000000000000000000000000000000009395 134.0
SHD2_k127_1182293_0 B3/4 domain K01890 - 6.1.1.20 8.102e-250 794.0
SHD2_k127_1182293_1 Endoribonuclease that initiates mRNA decay K18682 - - 1.595e-240 754.0
SHD2_k127_1182293_10 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000001785 137.0
SHD2_k127_1182293_11 Ribosomal protein L35 K02916 - - 0.0000000000000000007161 87.0
SHD2_k127_1182293_12 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000008231 87.0
SHD2_k127_1182293_13 - - - - 0.0000008307 55.0
SHD2_k127_1182293_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006265 593.0
SHD2_k127_1182293_3 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 442.0
SHD2_k127_1182293_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 432.0
SHD2_k127_1182293_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 416.0
SHD2_k127_1182293_6 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 371.0
SHD2_k127_1182293_7 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000201 267.0
SHD2_k127_1182293_8 EXOIII K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000003771 259.0
SHD2_k127_1182293_9 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000002983 183.0
SHD2_k127_1199257_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 1.685e-307 952.0
SHD2_k127_1199257_1 cellular manganese ion homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006491 370.0
SHD2_k127_1199257_2 PDZ domain (Also known as DHR or GLGF) - - - 0.000000000000000000000556 107.0
SHD2_k127_1200713_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.055e-232 744.0
SHD2_k127_1200713_1 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 521.0
SHD2_k127_1200713_2 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000001326 214.0
SHD2_k127_1200713_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000003882 164.0
SHD2_k127_1201782_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1330.0
SHD2_k127_1201782_1 Transglycosylase K21464 - 2.4.1.129,3.4.16.4 1.299e-276 864.0
SHD2_k127_1201782_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000001999 164.0
SHD2_k127_1214705_0 Peptidase dimerisation domain - - - 3.331e-194 617.0
SHD2_k127_1214705_1 COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 475.0
SHD2_k127_1214705_2 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 424.0
SHD2_k127_1214705_3 Glycosyl hydrolase family 20, domain 2 K12373 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000001446 253.0
SHD2_k127_1214705_4 glycosyl hydrolase - - - 0.00000000000000000000000000000000000000000000000000151 188.0
SHD2_k127_1214705_5 Belongs to the peptidase S8 family - - - 0.000000000000000000000006631 114.0
SHD2_k127_1218250_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.3 9.567e-255 801.0
SHD2_k127_1218250_1 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 605.0
SHD2_k127_1218250_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 445.0
SHD2_k127_1218250_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000001072 240.0
SHD2_k127_1218250_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000001136 186.0
SHD2_k127_1218250_6 - - - - 0.000000000004343 73.0
SHD2_k127_1241_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000895 497.0
SHD2_k127_1241_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 363.0
SHD2_k127_1241_2 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 364.0
SHD2_k127_1241_3 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 341.0
SHD2_k127_1241_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000151 260.0
SHD2_k127_1241_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000005269 216.0
SHD2_k127_1241_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.0000000000000000000000001438 107.0
SHD2_k127_1250093_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.753e-235 738.0
SHD2_k127_1250093_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 326.0
SHD2_k127_1250093_2 TonB dependent receptor - - - 0.0000000000000003914 79.0
SHD2_k127_1250093_3 TonB-dependent Receptor Plug K16092 - - 0.000008002 54.0
SHD2_k127_1250618_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 8.175e-194 612.0
SHD2_k127_1250618_1 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 380.0
SHD2_k127_1250618_2 PFAM metal-dependent phosphohydrolase, HD sub domain K02030,K06950,K07814,K09749,K16923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000313 272.0
SHD2_k127_1250618_3 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000000001188 186.0
SHD2_k127_1250618_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000004826 151.0
SHD2_k127_1250618_5 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00001153 49.0
SHD2_k127_125963_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1607.0
SHD2_k127_125963_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0 1072.0
SHD2_k127_125963_2 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1070.0
SHD2_k127_125963_3 RadC-like JAB domain K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 323.0
SHD2_k127_125963_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000006808 53.0
SHD2_k127_1277156_0 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008817 546.0
SHD2_k127_1277156_1 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000001027 252.0
SHD2_k127_128117_0 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 368.0
SHD2_k127_128117_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 328.0
SHD2_k127_128117_2 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000003015 189.0
SHD2_k127_128117_3 GAF domain - - - 0.00000000000000000000000000000000000000000000000001166 192.0
SHD2_k127_128117_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616,K08313,K08314 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016832,GO:0044424,GO:0044464,GO:0097023 2.2.1.2 0.00000000000000000000000000000000000000000001258 169.0
SHD2_k127_1284189_1 glycosyl transferase K20534 - - 0.00000000002794 63.0
SHD2_k127_1288414_0 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 338.0
SHD2_k127_1288414_1 Fe-S cluster K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 320.0
SHD2_k127_1288414_2 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000007301 209.0
SHD2_k127_1289294_0 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 347.0
SHD2_k127_1289294_1 transferase activity, transferring glycosyl groups K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 323.0
SHD2_k127_1289294_2 PFAM NAD dependent epimerase dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000001433 229.0
SHD2_k127_1289294_3 O-antigen polysaccharide polymerase Wzy - - - 0.0000000000000000009718 91.0
SHD2_k127_128966_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 473.0
SHD2_k127_128966_1 FecCD transport family K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007056 357.0
SHD2_k127_128966_2 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004359 305.0
SHD2_k127_128966_3 cobalamin-transporting ATPase activity K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001771 291.0
SHD2_k127_128966_4 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004889 258.0
SHD2_k127_128966_5 COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000002659 150.0
SHD2_k127_128966_6 Bifunctional nuclease K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000002857 124.0
SHD2_k127_1313456_0 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 532.0
SHD2_k127_1313456_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 382.0
SHD2_k127_1313456_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 315.0
SHD2_k127_1313456_3 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000005943 261.0
SHD2_k127_1313456_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000009038 207.0
SHD2_k127_1313456_5 Preprotein translocase subunit K03210 - - 0.000000000000000000000000000000371 125.0
SHD2_k127_1313456_6 Thiamine monophosphate synthase K00788,K10810 - 2.5.1.3,5.3.99.10 0.00000000000000000000000000003357 126.0
SHD2_k127_1313456_7 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000001369 107.0
SHD2_k127_1313456_8 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000000000000002145 104.0
SHD2_k127_1313456_9 Bifunctional sulfur carrier protein thiazole synthase K03154 - - 0.0000000000001123 74.0
SHD2_k127_1316072_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003231 347.0
SHD2_k127_1316072_1 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000002597 198.0
SHD2_k127_1316072_2 Putative glycosyl hydrolase domain - - - 0.0000003824 52.0
SHD2_k127_133071_0 Amidohydrolase family K06015 - 3.5.1.81 4.787e-245 768.0
SHD2_k127_133071_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 498.0
SHD2_k127_133071_2 Pyridoxal-phosphate dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 323.0
SHD2_k127_133071_3 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007874 255.0
SHD2_k127_133071_4 PFAM Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000004547 151.0
SHD2_k127_133071_5 SnoaL-like polyketide cyclase - - - 0.000000001341 66.0
SHD2_k127_1346048_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 458.0
SHD2_k127_1346048_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 355.0
SHD2_k127_1346048_2 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 298.0
SHD2_k127_1346048_3 Belongs to the BI1 family K06890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001948 259.0
SHD2_k127_1346048_4 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000004592 121.0
SHD2_k127_1346048_5 - - - - 0.00003038 51.0
SHD2_k127_1348559_0 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 531.0
SHD2_k127_1348559_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 311.0
SHD2_k127_1348559_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000004631 237.0
SHD2_k127_1348559_3 Tetratricopeptide repeat - - - 0.0000000000000427 74.0
SHD2_k127_1351454_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K13926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 369.0
SHD2_k127_1351454_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 359.0
SHD2_k127_1351454_2 PFAM secretion protein HlyD family protein K01993,K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003906 314.0
SHD2_k127_1351454_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000373 177.0
SHD2_k127_1351454_4 transcriptional regulator K09017 - - 0.000000003913 58.0
SHD2_k127_1355888_0 Atp-dependent helicase - - - 0.0 1237.0
SHD2_k127_1355888_1 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 568.0
SHD2_k127_1355888_2 D-glycero-D-manno-heptose 7-phosphate metabolic process K03271,K03272,K03525,K12961 GO:0003674,GO:0005488,GO:0005515,GO:0006275,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0042802,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0065007,GO:0080090,GO:0090329,GO:2000105,GO:2000112 2.7.1.167,2.7.1.33,2.7.7.70,5.3.1.28 0.000000000000000000000000000000000000000000000002059 179.0
SHD2_k127_1355888_3 LD-carboxypeptidase K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000005163 181.0
SHD2_k127_1355888_4 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000007047 166.0
SHD2_k127_1355888_5 Tfp pilus assembly protein FimT - - - 0.0000000000000000001652 94.0
SHD2_k127_1355888_6 - - - - 0.00000000000000636 84.0
SHD2_k127_1355888_7 Rdx family K07401 - - 0.00000606 50.0
SHD2_k127_1370311_0 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 301.0
SHD2_k127_1370311_1 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000009281 204.0
SHD2_k127_1370311_2 DinB family - - - 0.000000000000000000000000000000000000005975 151.0
SHD2_k127_1370311_3 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000007852 74.0
SHD2_k127_1387071_0 4Fe-4S dicluster domain K00184 - - 0.0 1249.0
SHD2_k127_1387071_1 Polysulphide reductase, NrfD K00185 - - 3.088e-257 799.0
SHD2_k127_1387071_10 SpoU rRNA Methylase family K02533,K15396 - 2.1.1.200 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006825 289.0
SHD2_k127_1387071_11 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000584 253.0
SHD2_k127_1387071_12 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003605 250.0
SHD2_k127_1387071_13 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001906 242.0
SHD2_k127_1387071_14 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000002261 247.0
SHD2_k127_1387071_15 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000001789 222.0
SHD2_k127_1387071_16 Thioredoxin-like domain K03672 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000003252 200.0
SHD2_k127_1387071_17 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000002423 192.0
SHD2_k127_1387071_18 Biopolymer transport protein ExbD/TolR K03559 - - 0.0000000000000000000000000000000000000000000000001817 181.0
SHD2_k127_1387071_19 - - - - 0.0000000000000000000000000000000000000000000000002637 188.0
SHD2_k127_1387071_2 Pfam Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007661 544.0
SHD2_k127_1387071_20 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000000000000000000000000004327 179.0
SHD2_k127_1387071_22 - - - - 0.000000000000000000000002078 115.0
SHD2_k127_1387071_23 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.000000000000000008308 87.0
SHD2_k127_1387071_24 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000009741 88.0
SHD2_k127_1387071_26 - - - - 0.00009187 53.0
SHD2_k127_1387071_27 - - - - 0.0002103 45.0
SHD2_k127_1387071_3 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 512.0
SHD2_k127_1387071_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 433.0
SHD2_k127_1387071_5 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006783 402.0
SHD2_k127_1387071_6 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 385.0
SHD2_k127_1387071_7 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 370.0
SHD2_k127_1387071_8 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 369.0
SHD2_k127_1387071_9 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 289.0
SHD2_k127_1407310_0 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 608.0
SHD2_k127_1407310_1 Fructose-bisphosphate aldolase class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000519 237.0
SHD2_k127_1407310_2 YtxH-like protein - - - 0.0000000000000000000000000000000001216 139.0
SHD2_k127_1407310_3 Virulence factor BrkB K07058 - - 0.000000000004152 66.0
SHD2_k127_1451511_0 cellulose binding - - - 0.0 1394.0
SHD2_k127_1451511_1 Outer membrane protein beta-barrel family - - - 1.913e-301 949.0
SHD2_k127_1451511_10 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 307.0
SHD2_k127_1451511_11 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 297.0
SHD2_k127_1451511_12 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009199 288.0
SHD2_k127_1451511_13 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008601 282.0
SHD2_k127_1451511_14 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000003516 271.0
SHD2_k127_1451511_15 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000703 263.0
SHD2_k127_1451511_16 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009581 254.0
SHD2_k127_1451511_17 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001739 258.0
SHD2_k127_1451511_18 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003465 242.0
SHD2_k127_1451511_19 lipopolysaccharide-transporting ATPase activity K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006984 244.0
SHD2_k127_1451511_2 Dehydrogenase - - - 5.36e-199 629.0
SHD2_k127_1451511_20 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001223 237.0
SHD2_k127_1451511_22 Glycosyl Transferase - - - 0.000000000000000000000000000000000000000000000000000000000009183 223.0
SHD2_k127_1451511_23 Cytochrome c K00376,K02305,K17760 - 1.1.9.1,1.7.2.4 0.0000000000000000000000000000000000000000000000000000000000132 221.0
SHD2_k127_1451511_24 Sortase and related acyltransferases K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000000000001606 210.0
SHD2_k127_1451511_25 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000001272 214.0
SHD2_k127_1451511_26 heme binding - - - 0.000000000000000000000000000000000000000000000000000000002044 211.0
SHD2_k127_1451511_27 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000001704 198.0
SHD2_k127_1451511_28 - - - - 0.000000000000000000000000000000000000000000000000004882 190.0
SHD2_k127_1451511_29 DinB family - - - 0.00000000000000000000000000000000000000000000000002864 183.0
SHD2_k127_1451511_3 TonB-linked outer membrane protein, SusC RagA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 589.0
SHD2_k127_1451511_30 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000000004643 174.0
SHD2_k127_1451511_31 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000007696 155.0
SHD2_k127_1451511_32 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000000005975 151.0
SHD2_k127_1451511_33 - - - - 0.0000000000000000000000000000000000001483 148.0
SHD2_k127_1451511_34 Domain of unknown function (DUF4956) - - - 0.000000000000000000000000000000000002895 151.0
SHD2_k127_1451511_35 SusD family K21572 - - 0.000000000000000000000000000000000758 147.0
SHD2_k127_1451511_36 - - - - 0.00000000000000000000000000000007888 128.0
SHD2_k127_1451511_37 SdiA-regulated - - - 0.0000000000000000000000000000004333 135.0
SHD2_k127_1451511_38 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity K02372,K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000005435 124.0
SHD2_k127_1451511_39 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000002226 120.0
SHD2_k127_1451511_4 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 497.0
SHD2_k127_1451511_41 - - - - 0.0000000000000000000001472 107.0
SHD2_k127_1451511_42 - - - - 0.00000000000000000009325 89.0
SHD2_k127_1451511_43 helix_turn_helix, Lux Regulon - - - 0.0000000000000002391 87.0
SHD2_k127_1451511_44 Domain of unknown function (DUF4397) - - - 0.0000000368 65.0
SHD2_k127_1451511_45 - - - - 0.0002709 51.0
SHD2_k127_1451511_5 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 459.0
SHD2_k127_1451511_6 membrane organization - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 458.0
SHD2_k127_1451511_7 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 376.0
SHD2_k127_1451511_8 Multicopper oxidase K08100 - 1.3.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004738 346.0
SHD2_k127_1451511_9 Beta-lactamase K21469 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 331.0
SHD2_k127_149225_0 alginic acid biosynthetic process - - - 1.303e-229 735.0
SHD2_k127_149225_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 6.386e-199 629.0
SHD2_k127_149225_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 517.0
SHD2_k127_149225_3 Peptidase family M23 K21472 - - 0.0000000000000000000000000000000000000000001173 166.0
SHD2_k127_149225_4 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000006022 154.0
SHD2_k127_149225_5 CRS1_YhbY K07574 - - 0.00000000000000000000000000000000001041 138.0
SHD2_k127_149225_6 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000004533 126.0
SHD2_k127_153083_0 TonB dependent receptor - - - 3.886e-292 928.0
SHD2_k127_153083_1 CarboxypepD_reg-like domain - - - 3.773e-288 920.0
SHD2_k127_153083_10 EAL domain K13950,K21025 - 2.6.1.85 0.000000000000000000000000000000000000000000000000000000000000000000002257 253.0
SHD2_k127_153083_11 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000124 226.0
SHD2_k127_153083_12 TPM domain K06872 - - 0.0000000000000000000000000000000000000000000000000000000000001137 223.0
SHD2_k127_153083_13 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000001284 202.0
SHD2_k127_153083_14 EAL domain - - - 0.000000000000000000000000000000000000000000000000000006728 207.0
SHD2_k127_153083_15 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000002871 172.0
SHD2_k127_153083_16 SusD family K21572 - - 0.0000000000000000000000000000000000000000000002162 185.0
SHD2_k127_153083_17 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000004604 115.0
SHD2_k127_153083_18 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000005782 101.0
SHD2_k127_153083_19 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000003022 80.0
SHD2_k127_153083_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.353e-260 809.0
SHD2_k127_153083_20 - - - - 0.0000000004472 65.0
SHD2_k127_153083_3 TonB-dependent receptor - - - 3.142e-252 817.0
SHD2_k127_153083_4 tRNA synthetases class I (M) K01874 - 6.1.1.10 8.897e-233 729.0
SHD2_k127_153083_5 PSP1 C-terminal conserved region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 419.0
SHD2_k127_153083_6 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007138 412.0
SHD2_k127_153083_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009959 331.0
SHD2_k127_153083_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 308.0
SHD2_k127_153083_9 nucleotidyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000011 272.0
SHD2_k127_1531005_0 Putative ATP-binding cassette K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 411.0
SHD2_k127_1531005_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 383.0
SHD2_k127_1531005_2 Multicopper oxidase - - - 0.00000001764 61.0
SHD2_k127_1543855_0 ABC transporter transmembrane region - - - 2.341e-238 750.0
SHD2_k127_1543855_1 CarboxypepD_reg-like domain - - - 2.477e-222 731.0
SHD2_k127_1543855_10 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000001042 99.0
SHD2_k127_1543855_2 Amino acid permease K03294 - - 2.501e-202 640.0
SHD2_k127_1543855_3 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 478.0
SHD2_k127_1543855_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 443.0
SHD2_k127_1543855_5 Predicted permease YjgP/YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006443 438.0
SHD2_k127_1543855_6 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 322.0
SHD2_k127_1543855_7 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 310.0
SHD2_k127_1543855_8 Cytochrome oxidase assembly protein K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000006899 239.0
SHD2_k127_1543855_9 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000001238 105.0
SHD2_k127_1553794_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1031.0
SHD2_k127_1553794_1 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001303 241.0
SHD2_k127_1553794_2 Alpha-tubulin suppressor and related RCC1 domain-containing - - - 0.0000000000000000000000000000000000000000000000000000000000000011 241.0
SHD2_k127_1553794_3 - - - - 0.00000000000000000000000000000000000000000000000345 175.0
SHD2_k127_1553794_4 VKc - - - 0.0000000000000000000497 96.0
SHD2_k127_1593621_0 Putative modulator of DNA gyrase K03568 - - 8.949e-230 721.0
SHD2_k127_1593621_1 nucleotide catabolic process K01081,K11751,K17224 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 466.0
SHD2_k127_1593621_2 Diacylglycerol kinase catalytic domain (presumed) K07029 - 2.7.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002847 278.0
SHD2_k127_1593621_3 Serine phosphatase RsbU, regulator of sigma subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000003003 250.0
SHD2_k127_1593621_4 Protease prsW family - - - 0.0000000000000000000000000000002028 138.0
SHD2_k127_1593621_5 - - - - 0.0003166 44.0
SHD2_k127_164654_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 586.0
SHD2_k127_164654_1 Isocitrate/isopropylmalate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 331.0
SHD2_k127_1670611_0 Sortilin, neurotensin receptor 3, - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 331.0
SHD2_k127_1670611_1 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000000000000001024 200.0
SHD2_k127_1670611_2 - - - - 0.00000000000000000000000000000000000000000000003237 177.0
SHD2_k127_1670611_3 - - - - 0.00000000000000000000000000000000000000000000003664 185.0
SHD2_k127_1670611_4 iron-nicotianamine transmembrane transporter activity - - - 0.000000000000000000000004708 104.0
SHD2_k127_1670611_5 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000000003846 90.0
SHD2_k127_1685871_0 MMPL family K03296 - - 0.0 1122.0
SHD2_k127_1685871_1 Uncharacterized protein family (UPF0051) K09014 - - 2.714e-258 801.0
SHD2_k127_1685871_10 ATPase activity - - - 0.0000000001077 69.0
SHD2_k127_1685871_2 Enoyl-(Acyl carrier protein) reductase - - - 1.829e-226 706.0
SHD2_k127_1685871_3 Uncharacterized protein family (UPF0051) K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009393 460.0
SHD2_k127_1685871_4 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007154 403.0
SHD2_k127_1685871_5 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005422 302.0
SHD2_k127_1685871_6 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001991 296.0
SHD2_k127_1685871_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002077 234.0
SHD2_k127_1685871_8 SnoaL-like domain - - - 0.000000000000000000000000000000000000001655 153.0
SHD2_k127_1685871_9 - - - - 0.00000000000000002529 83.0
SHD2_k127_1707533_0 - - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 - 0.0 1368.0
SHD2_k127_1707533_1 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 595.0
SHD2_k127_1707533_2 General secretory system II protein E domain protein K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 567.0
SHD2_k127_1707533_3 Peptidase M28 - - - 0.000000000000000000000000000000000000000000000000000000000002898 220.0
SHD2_k127_1707533_4 Helix-hairpin-helix motif K02237 - - 0.0000000000000000000000001182 113.0
SHD2_k127_1707533_5 Type II secretion system (T2SS), protein F K02653 - - 0.00000000003732 66.0
SHD2_k127_1727384_0 Bacterial regulatory protein, Fis family - - - 1.618e-211 669.0
SHD2_k127_1727384_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 513.0
SHD2_k127_1727384_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 497.0
SHD2_k127_1727384_3 Pyridoxamine 5'-phosphate oxidase K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000007676 232.0
SHD2_k127_1727384_4 - - - - 0.00000000000000000000000000000000000000000000000000000001015 206.0
SHD2_k127_1727384_5 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000001611 198.0
SHD2_k127_1727384_6 peroxiredoxin activity K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000000000000000000000000007555 141.0
SHD2_k127_1727384_7 Bacterioferritin comigratory protein K03564 - 1.11.1.15 0.000000000405 62.0
SHD2_k127_1781171_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 376.0
SHD2_k127_1781171_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000007775 201.0
SHD2_k127_1781171_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000003062 171.0
SHD2_k127_1781171_3 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000001346 165.0
SHD2_k127_1781171_4 Peptidase family M28 - - - 0.000006434 48.0
SHD2_k127_1820157_0 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 320.0
SHD2_k127_1820157_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000000000000000000008509 221.0
SHD2_k127_1820157_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000000000000000000001398 206.0
SHD2_k127_1820157_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000008151 95.0
SHD2_k127_1820157_4 ABC1 family - - - 0.000000000000000002026 87.0
SHD2_k127_1837262_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1129.0
SHD2_k127_1837262_1 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 6.437e-213 670.0
SHD2_k127_1837262_2 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 430.0
SHD2_k127_1837262_3 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 380.0
SHD2_k127_1837262_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 361.0
SHD2_k127_1837262_5 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 325.0
SHD2_k127_1837262_6 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008454 283.0
SHD2_k127_1837262_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000005479 114.0
SHD2_k127_1871532_0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 1.656e-260 818.0
SHD2_k127_1871532_1 Uncharacterised protein family (UPF0182) K09118 - - 2.549e-245 786.0
SHD2_k127_1871532_10 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 287.0
SHD2_k127_1871532_11 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005141 274.0
SHD2_k127_1871532_12 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006586 258.0
SHD2_k127_1871532_14 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000002048 233.0
SHD2_k127_1871532_15 Leishmanolysin - - - 0.000000000000000000000000000000000000000000000003249 179.0
SHD2_k127_1871532_16 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000000002881 177.0
SHD2_k127_1871532_17 acid phosphatase - - - 0.000000000000000000000000000000000000000005515 169.0
SHD2_k127_1871532_18 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000001956 165.0
SHD2_k127_1871532_2 Pyridine nucleotide-disulphide oxidoreductase - - - 3.264e-199 633.0
SHD2_k127_1871532_20 Methyltransferase type 11 - - - 0.00000000000000000000000001827 116.0
SHD2_k127_1871532_21 Predicted membrane protein (DUF2339) - - - 0.000000000000000000001367 110.0
SHD2_k127_1871532_3 CarboxypepD_reg-like domain K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 557.0
SHD2_k127_1871532_4 PFAM Ribonuclease II K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 484.0
SHD2_k127_1871532_5 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 488.0
SHD2_k127_1871532_6 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 464.0
SHD2_k127_1871532_7 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 449.0
SHD2_k127_1871532_8 Fusaric acid resistance protein-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 398.0
SHD2_k127_1871532_9 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 315.0
SHD2_k127_1889769_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 5.923e-203 639.0
SHD2_k127_1889769_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 396.0
SHD2_k127_1889769_2 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 320.0
SHD2_k127_1889769_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000585 47.0
SHD2_k127_1932143_0 Telomere recombination K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008463 330.0
SHD2_k127_1932143_1 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 306.0
SHD2_k127_1932143_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000005227 224.0
SHD2_k127_1974061_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 571.0
SHD2_k127_1974061_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000000000000000001427 221.0
SHD2_k127_1974061_2 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000002577 132.0
SHD2_k127_1974061_3 Lipoprotein K05811 - - 0.00003435 52.0
SHD2_k127_1976892_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 452.0
SHD2_k127_1976892_1 Putative peptidoglycan binding domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 356.0
SHD2_k127_1976892_2 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 315.0
SHD2_k127_1976892_3 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0001485 45.0
SHD2_k127_1976892_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0005502 47.0
SHD2_k127_1984807_0 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 588.0
SHD2_k127_1984807_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 357.0
SHD2_k127_1984807_2 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 314.0
SHD2_k127_1984807_3 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001955 263.0
SHD2_k127_1984807_4 - - - - 0.000000000000000000000000000000000000000000001883 179.0
SHD2_k127_1984807_5 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000004916 151.0
SHD2_k127_1984807_6 - - - - 0.000000000000000000000001899 113.0
SHD2_k127_1984807_7 Pirin C-terminal cupin domain - - - 0.00000000000000000005235 92.0
SHD2_k127_1984807_8 Methylamine utilisation protein MauE - - - 0.00000001257 65.0
SHD2_k127_1984807_9 Cupin 2, conserved barrel domain protein - - - 0.0000002755 59.0
SHD2_k127_2037872_0 AcrB/AcrD/AcrF family K15726 - - 0.0 1485.0
SHD2_k127_2037872_1 Phosphate acetyl/butaryl transferase K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 0.0 1190.0
SHD2_k127_2037872_10 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007719 251.0
SHD2_k127_2037872_2 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 5.782e-280 867.0
SHD2_k127_2037872_3 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008578 571.0
SHD2_k127_2037872_4 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 418.0
SHD2_k127_2037872_5 Outer membrane efflux protein K15725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 409.0
SHD2_k127_2037872_6 Barrel-sandwich domain of CusB or HlyD membrane-fusion K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 384.0
SHD2_k127_2037872_7 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 369.0
SHD2_k127_2037872_8 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 352.0
SHD2_k127_2037872_9 Part of the ABC transporter FtsEX involved in K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 310.0
SHD2_k127_2044376_0 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001447 282.0
SHD2_k127_2044376_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800,K00945 - 2.5.1.19,2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000003346 230.0
SHD2_k127_2044376_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000003434 183.0
SHD2_k127_2044376_3 Bacterial membrane protein YfhO - - - 0.000000000000002187 81.0
SHD2_k127_2065883_0 Sodium/hydrogen exchanger family K03455 - - 3.305e-220 704.0
SHD2_k127_2065883_1 - - - - 0.00000000000000000000000000000005764 130.0
SHD2_k127_2066782_0 alpha beta alpha domain I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 573.0
SHD2_k127_2066782_1 mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 451.0
SHD2_k127_2074836_0 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 459.0
SHD2_k127_2074836_1 PFAM bifunctional deaminase-reductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001455 259.0
SHD2_k127_2074836_2 PFAM DNA RNA tunnel of bacterial DNA dependent RNA polymerase - - - 0.000000000000000000000000000000000000000000000000000001429 194.0
SHD2_k127_2074836_3 Ricin-type beta-trefoil - - - 0.000000001312 70.0
SHD2_k127_20788_0 Methionine synthase B12-binding module cap domain protein K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1294.0
SHD2_k127_208170_0 Catalase K03781 - 1.11.1.6 2.103e-243 763.0
SHD2_k127_208170_1 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 629.0
SHD2_k127_208170_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006833 241.0
SHD2_k127_208170_11 methyltransferase - - - 0.00000000000000000000000000000000000004944 149.0
SHD2_k127_208170_12 - - - - 0.00000000000000000000000000000000001097 139.0
SHD2_k127_208170_13 DinB superfamily - - - 0.00000000000000000000000000000000002387 142.0
SHD2_k127_208170_2 Putative zinc-binding metallo-peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006293 473.0
SHD2_k127_208170_3 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 409.0
SHD2_k127_208170_4 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 403.0
SHD2_k127_208170_5 SIS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 385.0
SHD2_k127_208170_6 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 394.0
SHD2_k127_208170_7 Protein conserved in bacteria K01446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005336 374.0
SHD2_k127_208170_8 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 318.0
SHD2_k127_208170_9 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005879 274.0
SHD2_k127_2099376_0 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 446.0
SHD2_k127_2099376_1 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 364.0
SHD2_k127_2099376_2 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000005746 218.0
SHD2_k127_2099376_3 Predicted periplasmic lipoprotein (DUF2279) - - - 0.000000000000000000000000000008294 131.0
SHD2_k127_2099376_4 Capsule assembly protein Wzi - - - 0.0000000000000000001933 102.0
SHD2_k127_2099376_5 Polysaccharide biosynthesis/export protein K01991 - - 0.000000000000000005976 90.0
SHD2_k127_2118770_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 553.0
SHD2_k127_2118770_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000002147 199.0
SHD2_k127_2121287_0 Amidase K01426 - 3.5.1.4 1.395e-210 665.0
SHD2_k127_2121370_0 Capsule assembly protein Wzi - - - 0.00000000000000000000005328 114.0
SHD2_k127_2125481_0 ribonuclease E activity K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 411.0
SHD2_k127_2125481_1 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 300.0
SHD2_k127_2125481_2 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000002567 217.0
SHD2_k127_2125481_3 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000000000000000000196 160.0
SHD2_k127_2125481_4 Ribosomal L27 protein K02899 - - 0.0000000000000000000000000000000000000001042 151.0
SHD2_k127_2133199_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 7.27e-286 887.0
SHD2_k127_2133199_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 509.0
SHD2_k127_2133199_2 Amidohydrolase family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 510.0
SHD2_k127_2133199_3 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 334.0
SHD2_k127_2133199_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000001647 210.0
SHD2_k127_213760_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.085e-200 633.0
SHD2_k127_213760_1 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009697 260.0
SHD2_k127_213760_2 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000000000000003637 166.0
SHD2_k127_213760_3 - - - - 0.0000000000004334 80.0
SHD2_k127_213760_4 Participates in both transcription termination and antitermination K02600 - - 0.00000000008138 63.0
SHD2_k127_2141755_0 Acts as a magnesium transporter K06213 - - 9.602e-195 619.0
SHD2_k127_2141755_1 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 439.0
SHD2_k127_2141755_2 acyl-CoA dehydrogenase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000001517 138.0
SHD2_k127_2141755_3 - - - - 0.000000000004215 73.0
SHD2_k127_2141755_4 haemagglutination activity domain - - - 0.0000000002549 70.0
SHD2_k127_2141755_5 mercury ion transmembrane transporter activity K07213 - - 0.0000004094 57.0
SHD2_k127_2141755_6 Dystroglycan-type cadherin-like domains. - - - 0.000002267 58.0
SHD2_k127_2156268_0 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 343.0
SHD2_k127_2156268_1 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 312.0
SHD2_k127_2156268_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000000000000000000000045 258.0
SHD2_k127_2156268_3 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000007181 197.0
SHD2_k127_2156268_4 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000001579 198.0
SHD2_k127_2156268_5 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000001861 189.0
SHD2_k127_2156268_6 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000006733 188.0
SHD2_k127_2156268_7 cyclic nucleotide binding K12132,K20074 - 2.7.11.1,3.1.3.16 0.00000000000000000000000000000000003523 154.0
SHD2_k127_2156268_8 PLD-like domain - - - 0.0000003307 54.0
SHD2_k127_2156268_9 cheY-homologous receiver domain K20977 - - 0.000001994 54.0
SHD2_k127_2160880_0 GIY-YIG type nucleases (URI domain) K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 422.0
SHD2_k127_2160880_1 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008262 373.0
SHD2_k127_2160880_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 324.0
SHD2_k127_2160880_3 ECF sigma factor K03088 - - 0.00000000000000000000000007431 108.0
SHD2_k127_2168801_0 Acts as a magnesium transporter K06213 GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 531.0
SHD2_k127_2168801_1 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 427.0
SHD2_k127_2168801_10 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000304 142.0
SHD2_k127_2168801_11 glycosyl transferase family 2 - - - 0.0000000000000000000000000001006 128.0
SHD2_k127_2168801_12 Methyltransferase type 12 - - - 0.000000000000000000005878 108.0
SHD2_k127_2168801_13 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000335 93.0
SHD2_k127_2168801_14 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000001509 59.0
SHD2_k127_2168801_2 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 375.0
SHD2_k127_2168801_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000836 273.0
SHD2_k127_2168801_4 Glycosyl transferases group 1 K12994 - 2.4.1.349 0.0000000000000000000000000000000000000000000000000000000000000001552 235.0
SHD2_k127_2168801_5 Ham1 family K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000001671 215.0
SHD2_k127_2168801_6 inositol 2-dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000003049 218.0
SHD2_k127_2168801_7 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000003146 192.0
SHD2_k127_2168801_8 Ferric reductase like transmembrane component - - - 0.000000000000000000000000000000000002766 145.0
SHD2_k127_2168801_9 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000001006 143.0
SHD2_k127_2179704_0 DALR_2 K01883 - 6.1.1.16 8.694e-208 655.0
SHD2_k127_2179704_1 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 422.0
SHD2_k127_2179704_2 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 310.0
SHD2_k127_2179704_3 Serine dehydratase alpha chain K01752 - 4.3.1.17 0.000000000000000000000000000000000000000000001542 165.0
SHD2_k127_2179704_4 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000001367 98.0
SHD2_k127_2179704_5 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000138 76.0
SHD2_k127_2184233_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 1.37e-221 704.0
SHD2_k127_2184233_1 Hsp70 protein K03569 - - 2.193e-200 626.0
SHD2_k127_2184233_2 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 609.0
SHD2_k127_2184233_3 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008691 570.0
SHD2_k127_2184233_4 Cell cycle protein K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007726 560.0
SHD2_k127_2184233_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 440.0
SHD2_k127_2184233_6 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 321.0
SHD2_k127_2184233_7 rod shape-determining protein MreC K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007643 274.0
SHD2_k127_2184233_8 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000000000000000000000000000000000003202 204.0
SHD2_k127_2197313_0 AMP-binding enzyme C-terminal domain K01907 - 6.2.1.16 3.784e-272 853.0
SHD2_k127_2197313_1 TonB dependent receptor - - - 5.228e-256 815.0
SHD2_k127_2197313_2 SusD family K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 345.0
SHD2_k127_2197313_3 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.0000000000003236 69.0
SHD2_k127_2206199_0 Oxidoreductase family, NAD-binding Rossmann fold K00118,K13020 - 1.1.1.335,1.1.99.28 0.000000000000000000000000000000000000000000000000000000004 215.0
SHD2_k127_2206199_1 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000003244 107.0
SHD2_k127_2214870_0 protein histidine kinase activity - - - 7.605e-276 861.0
SHD2_k127_2221125_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1204.0
SHD2_k127_2221125_1 Peptidase family M49 - - - 1.897e-200 640.0
SHD2_k127_2221125_2 metallopeptidase activity K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 428.0
SHD2_k127_2221125_3 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000004505 211.0
SHD2_k127_2221529_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 4.176e-203 638.0
SHD2_k127_2221529_1 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 614.0
SHD2_k127_2221529_2 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 375.0
SHD2_k127_2221529_3 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 362.0
SHD2_k127_2221529_4 TipAS antibiotic-recognition domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006568 255.0
SHD2_k127_2221529_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008164 255.0
SHD2_k127_2221529_6 - - - - 0.0000000000005376 74.0
SHD2_k127_2231727_0 Peptidase family M28 - - - 8.639e-247 772.0
SHD2_k127_2231727_1 membrane protein, hemolysin III homolog K11068 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002419 259.0
SHD2_k127_2231727_2 - - - - 0.0000000000000000000000000002941 123.0
SHD2_k127_2253481_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298,K15408 - 1.10.3.10,1.9.3.1 1.72e-287 895.0
SHD2_k127_2253481_1 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 284.0
SHD2_k127_225454_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 481.0
SHD2_k127_225454_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 312.0
SHD2_k127_225454_2 Cytochrome c K07243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 313.0
SHD2_k127_225454_3 Glutathione peroxidase - - - 0.000000000000000000000000000000000000000000000000003422 187.0
SHD2_k127_225454_4 CYTH domain K01768,K05873 - 4.6.1.1 0.000000000000000000000000000000000000407 145.0
SHD2_k127_225454_5 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000004682 108.0
SHD2_k127_225454_6 - - - - 0.00000000001876 72.0
SHD2_k127_2260766_0 response to antibiotic K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 455.0
SHD2_k127_2260766_1 Protein of unknown function (DUF455) - - - 0.000004141 57.0
SHD2_k127_2260766_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K03921 - 1.14.19.11,1.14.19.2,1.14.19.26,1.16.3.1 0.0000178 55.0
SHD2_k127_2262211_0 Sortilin, neurotensin receptor 3, - - - 0.0 1455.0
SHD2_k127_2262211_1 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 4.768e-307 950.0
SHD2_k127_2262211_10 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009924 265.0
SHD2_k127_2262211_11 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000008876 242.0
SHD2_k127_2262211_12 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000004742 241.0
SHD2_k127_2262211_13 DJ-1/PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000006908 233.0
SHD2_k127_2262211_14 Nicotinamide mononucleotide transporter K03811 - - 0.000000000000000000000000000000000000000000000000000000000000000001005 232.0
SHD2_k127_2262211_15 Oxidoreductase family, NAD-binding Rossmann fold K00118,K13020 - 1.1.1.335,1.1.99.28 0.00000000000000000000000000000000000000000000000000000000001031 220.0
SHD2_k127_2262211_16 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000001805 207.0
SHD2_k127_2262211_17 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000001956 205.0
SHD2_k127_2262211_18 Diacylglycerol kinase catalytic domain (presumed) K07029 - 2.7.1.107 0.0000000000000000000000000000000000000000000001936 179.0
SHD2_k127_2262211_19 lipoprotein YddW precursor K01189 - - - 0.000000000000000000000000000000000000000003337 171.0
SHD2_k127_2262211_2 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 406.0
SHD2_k127_2262211_20 - - - - 0.0000000000000000000000000000000000000001709 156.0
SHD2_k127_2262211_21 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000001693 148.0
SHD2_k127_2262211_22 - - - - 0.0000000000000000000000000000001082 129.0
SHD2_k127_2262211_23 Major Facilitator Superfamily - - - 0.0000000000000000000000001664 107.0
SHD2_k127_2262211_24 PFAM Bacterial regulatory proteins, gntR family K07979 - - 0.000000000000000000000008015 106.0
SHD2_k127_2262211_28 - - - - 0.000002147 57.0
SHD2_k127_2262211_3 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009015 382.0
SHD2_k127_2262211_4 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 354.0
SHD2_k127_2262211_5 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 347.0
SHD2_k127_2262211_6 SPFH Band 7 PHB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 336.0
SHD2_k127_2262211_7 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 311.0
SHD2_k127_2262211_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001199 275.0
SHD2_k127_2262211_9 zinc D-Ala-D-Ala carboxypeptidase activity K08641 - 3.4.13.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000002344 261.0
SHD2_k127_2287933_0 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 591.0
SHD2_k127_2287933_1 Aminotransferase class-V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 565.0
SHD2_k127_2287933_10 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 389.0
SHD2_k127_2287933_11 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 357.0
SHD2_k127_2287933_12 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 319.0
SHD2_k127_2287933_13 tryptophan 2,3-dioxygenase activity K00453 - 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 303.0
SHD2_k127_2287933_14 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 298.0
SHD2_k127_2287933_15 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000002148 267.0
SHD2_k127_2287933_16 Roadblock/LC7 domain - - - 0.000000000000000000000000000000000000000000000000000000000565 205.0
SHD2_k127_2287933_17 Peptidase family M23 K21472 - - 0.000000000000000000000000000000000000000000001951 173.0
SHD2_k127_2287933_18 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000001153 169.0
SHD2_k127_2287933_19 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000001565 132.0
SHD2_k127_2287933_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 548.0
SHD2_k127_2287933_20 - - - - 0.00000000000000000000005162 101.0
SHD2_k127_2287933_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 539.0
SHD2_k127_2287933_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 526.0
SHD2_k127_2287933_5 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 516.0
SHD2_k127_2287933_6 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 486.0
SHD2_k127_2287933_7 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 475.0
SHD2_k127_2287933_8 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 469.0
SHD2_k127_2287933_9 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 420.0
SHD2_k127_2293518_0 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 1.945e-198 624.0
SHD2_k127_2293518_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 582.0
SHD2_k127_2293518_2 Putative metal-binding domain of cation transport ATPase K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 584.0
SHD2_k127_2293518_3 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.00000000000000000000000000000000000000000000000000000000000000002819 228.0
SHD2_k127_2293518_4 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.00000000000000000000000000000000000000000000000000000000008023 211.0
SHD2_k127_2293518_5 FixH - - - 0.00000000000000000000009138 106.0
SHD2_k127_2293518_6 Cbb3-type cytochrome oxidase K00407 - - 0.00005102 52.0
SHD2_k127_229681_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005178 524.0
SHD2_k127_229681_1 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 505.0
SHD2_k127_229681_2 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 364.0
SHD2_k127_2296834_0 Glycosyl hydrolase-like 10 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 587.0
SHD2_k127_2296834_1 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000004068 210.0
SHD2_k127_2296834_2 Aspartyl protease - - - 0.00000000000000000000000000000000007039 150.0
SHD2_k127_2303775_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 346.0
SHD2_k127_2303775_1 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 327.0
SHD2_k127_230405_0 DHH family K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 608.0
SHD2_k127_230405_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000722 561.0
SHD2_k127_230405_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 482.0
SHD2_k127_230405_3 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 317.0
SHD2_k127_230405_4 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000003925 213.0
SHD2_k127_230405_5 STAS domain K04749 - - 0.000000000000000000000000000000000000000000000000000003971 192.0
SHD2_k127_230405_6 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000000000006899 192.0
SHD2_k127_230405_7 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.00000000000000000000000000000000000000000007454 169.0
SHD2_k127_230405_8 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000000000000000000000000005779 158.0
SHD2_k127_2307320_0 asparaginase activity K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 400.0
SHD2_k127_2307320_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002073 250.0
SHD2_k127_2307320_2 Lipocalin-like domain - - - 0.000000000000000000000000000002243 126.0
SHD2_k127_2308317_0 Polysaccharide biosynthesis protein K15894 - 4.2.1.115 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 479.0
SHD2_k127_2308317_1 SAF K01654 - 2.5.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 319.0
SHD2_k127_2308317_2 PFAM NAD-dependent epimerase dehydratase K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000006655 186.0
SHD2_k127_2308317_3 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.0000003774 59.0
SHD2_k127_2309343_0 permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 2.805e-194 617.0
SHD2_k127_2309343_1 PFAM amidohydrolase K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 349.0
SHD2_k127_2309343_2 Aminotransferase class-III - - - 0.0000000000000000000000000625 108.0
SHD2_k127_2317459_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 1.89e-255 812.0
SHD2_k127_2317459_1 Amidohydrolase family - - - 3.284e-230 722.0
SHD2_k127_2317459_10 Acyltransferase - - - 0.000000000000000000000000000000000000000000000000000004808 196.0
SHD2_k127_2317459_11 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000000000000000000001651 147.0
SHD2_k127_2317459_12 Glyoxalase-like domain K05606 - 5.1.99.1 0.00000000000000000000000000000000001745 139.0
SHD2_k127_2317459_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000001832 136.0
SHD2_k127_2317459_14 response to antibiotic K00573 - 2.1.1.77 0.000000000000000000000000008483 111.0
SHD2_k127_2317459_15 PFAM S23 ribosomal protein - - - 0.00000000000000000000282 98.0
SHD2_k127_2317459_16 lytic transglycosylase activity - - - 0.000000000000002233 85.0
SHD2_k127_2317459_17 - - - - 0.000000109 57.0
SHD2_k127_2317459_19 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.0001109 47.0
SHD2_k127_2317459_2 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 553.0
SHD2_k127_2317459_3 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 416.0
SHD2_k127_2317459_4 PAS fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 356.0
SHD2_k127_2317459_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003598 250.0
SHD2_k127_2317459_6 acetyltransferases and hydrolases with the alpha beta hydrolase fold K01046 - 3.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000007014 241.0
SHD2_k127_2317459_7 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000002 228.0
SHD2_k127_2317459_8 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000002188 237.0
SHD2_k127_2317459_9 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000000000000000000002633 200.0
SHD2_k127_2343604_0 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 409.0
SHD2_k127_2343604_1 Phosphoribosyl transferase domain K07101 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002872 261.0
SHD2_k127_2343604_2 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000223 186.0
SHD2_k127_2343604_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000023 186.0
SHD2_k127_2343604_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0000000000000000000000000000143 120.0
SHD2_k127_2343604_5 4-vinyl reductase, 4VR - - - 0.00000000000000000000004802 105.0
SHD2_k127_2343604_6 - - - - 0.000000000000000000008134 102.0
SHD2_k127_2345827_0 3-oxoacyl-[acyl-carrier-protein] synthase activity K09458,K14660 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 528.0
SHD2_k127_2345827_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005452 468.0
SHD2_k127_2345827_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000001778 219.0
SHD2_k127_2345827_3 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000008253 175.0
SHD2_k127_2345827_4 Peptidase C26 K01658 - 4.1.3.27 0.00000000000000000000000000000000000000001669 158.0
SHD2_k127_2345827_5 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000001779 135.0
SHD2_k127_2365660_0 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 4.092e-216 698.0
SHD2_k127_2365660_1 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 413.0
SHD2_k127_2365660_10 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000000000000000000000000000001338 173.0
SHD2_k127_2365660_11 Glycoprotease family K14742 - - 0.00000000000000000000000000000000000000000127 165.0
SHD2_k127_2365660_12 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000000005465 138.0
SHD2_k127_2365660_13 OmpA family K03640 - - 0.0000000000000000000000000004815 123.0
SHD2_k127_2365660_14 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.00000000000006003 83.0
SHD2_k127_2365660_15 PFAM Peptidoglycan-binding LysM - - - 0.0000000000001796 82.0
SHD2_k127_2365660_16 cytochrome complex assembly - - - 0.0000000000004513 79.0
SHD2_k127_2365660_17 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000003202 60.0
SHD2_k127_2365660_2 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 328.0
SHD2_k127_2365660_3 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 313.0
SHD2_k127_2365660_4 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000263 280.0
SHD2_k127_2365660_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001202 275.0
SHD2_k127_2365660_6 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000000000000000000065 211.0
SHD2_k127_2365660_7 TonB C terminal K03832 - - 0.00000000000000000000000000000000000000000000000000000004693 204.0
SHD2_k127_2365660_8 Outer membrane lipoprotein - - - 0.000000000000000000000000000000000000000000000000000006528 200.0
SHD2_k127_2365660_9 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000007357 185.0
SHD2_k127_2389017_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 2.267e-313 968.0
SHD2_k127_2389017_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 1.301e-302 947.0
SHD2_k127_2389017_10 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001507 270.0
SHD2_k127_2389017_11 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000001209 226.0
SHD2_k127_2389017_12 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.00000000000000000000000000000000000000000000000000000001448 201.0
SHD2_k127_2389017_13 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000000001571 195.0
SHD2_k127_2389017_14 - - - - 0.00000000000000000000000000000000000000000000000001952 187.0
SHD2_k127_2389017_15 Lipopolysaccharide kinase (Kdo/WaaP) family K11211 - 2.7.1.166 0.0000000000000000000000000000000000000000006477 167.0
SHD2_k127_2389017_16 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000001112 69.0
SHD2_k127_2389017_2 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 6.502e-233 724.0
SHD2_k127_2389017_3 Anthranilate synthase component I, N terminal region K01657 - 4.1.3.27 1.587e-217 685.0
SHD2_k127_2389017_4 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 2.77e-205 647.0
SHD2_k127_2389017_5 - - - - 7.962e-204 655.0
SHD2_k127_2389017_6 Glycosyltransferase family 9 (heptosyltransferase) K12982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 477.0
SHD2_k127_2389017_7 O-acyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 419.0
SHD2_k127_2389017_8 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 423.0
SHD2_k127_2389017_9 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004379 278.0
SHD2_k127_2405050_0 stress-induced mitochondrial fusion - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 498.0
SHD2_k127_2405050_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 295.0
SHD2_k127_2405050_2 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000005497 251.0
SHD2_k127_2441222_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 477.0
SHD2_k127_2441222_1 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 353.0
SHD2_k127_2449785_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000672 480.0
SHD2_k127_2449785_1 secondary active sulfate transmembrane transporter activity K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 441.0
SHD2_k127_2449785_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 415.0
SHD2_k127_2449785_3 Peptidase S24-like K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 337.0
SHD2_k127_2449785_4 Disulphide isomerase - - - 0.00000000000000000000000000000000000000000000000000000003653 203.0
SHD2_k127_2449785_5 - - - - 0.0000000000000000000000000001397 122.0
SHD2_k127_2453361_0 DNA restriction-modification system - - - 1.431e-267 857.0
SHD2_k127_2453361_1 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 507.0
SHD2_k127_2453361_2 SNF2 family N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 330.0
SHD2_k127_2453361_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000004435 192.0
SHD2_k127_2453361_4 Domain of unknown function (DUF4440) - - - 0.0000000000000000000000000000000003975 135.0
SHD2_k127_2453361_5 FR47-like protein - - - 0.0000000000006593 71.0
SHD2_k127_2458388_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009397 441.0
SHD2_k127_2458388_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000005257 218.0
SHD2_k127_2471383_0 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 603.0
SHD2_k127_2471383_1 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009886 452.0
SHD2_k127_2471383_2 chorismate binding enzyme K02552 - 5.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 385.0
SHD2_k127_2471383_3 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000077 232.0
SHD2_k127_2471383_4 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000001634 227.0
SHD2_k127_2471383_5 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007,K21787 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 2.7.9.2 0.000000000000000000000000000000000002357 141.0
SHD2_k127_2471383_6 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000001808 139.0
SHD2_k127_2471383_7 Cupin 2, conserved barrel domain protein - - - 0.0000000005318 65.0
SHD2_k127_2475249_0 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 508.0
SHD2_k127_2475249_1 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000008449 252.0
SHD2_k127_2475249_2 Formiminotransferase domain, N-terminal subdomain K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000008307 89.0
SHD2_k127_2505897_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 435.0
SHD2_k127_2505897_1 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739,K01758 - 2.5.1.48,4.4.1.1 0.000000000000000000000000000004861 122.0
SHD2_k127_2507809_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 1.556e-252 783.0
SHD2_k127_2507809_1 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 584.0
SHD2_k127_2507809_10 Domain of unknown function (DUF4321) - - - 0.00000000000000000000000000000000005177 135.0
SHD2_k127_2507809_11 Ftsk_gamma K03466 - - 0.00000000000000000000000009012 114.0
SHD2_k127_2507809_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000004806 89.0
SHD2_k127_2507809_2 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 538.0
SHD2_k127_2507809_3 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 448.0
SHD2_k127_2507809_4 Polyprenyl synthetase K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 329.0
SHD2_k127_2507809_5 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 294.0
SHD2_k127_2507809_6 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000000000000008126 218.0
SHD2_k127_2507809_7 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000004462 182.0
SHD2_k127_2507809_8 - - - - 0.0000000000000000000000000000000000000000001551 168.0
SHD2_k127_2507809_9 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000001192 179.0
SHD2_k127_2511722_0 Beta-eliminating lyase K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005195 367.0
SHD2_k127_2511722_1 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000001455 220.0
SHD2_k127_2511722_3 OST-HTH/LOTUS domain - - - 0.0000000003612 66.0
SHD2_k127_256996_0 Transglycosylase K21464 - 2.4.1.129,3.4.16.4 1.437e-254 803.0
SHD2_k127_256996_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 1.975e-229 717.0
SHD2_k127_256996_2 Protein of unknown function (DUF1501) - - - 1.705e-196 623.0
SHD2_k127_256996_3 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 605.0
SHD2_k127_256996_4 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 559.0
SHD2_k127_256996_5 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 387.0
SHD2_k127_256996_6 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 306.0
SHD2_k127_256996_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000001831 206.0
SHD2_k127_256996_8 - - - - 0.0000000000000000000000000000000000000000000000003003 184.0
SHD2_k127_256996_9 PFAM Acetyltransferase (GNAT) family - - - 0.000005234 56.0
SHD2_k127_2591960_0 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 500.0
SHD2_k127_2591960_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 505.0
SHD2_k127_2591960_2 Alanine dehydrogenase/PNT, C-terminal domain K07538 - 1.1.1.368 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 352.0
SHD2_k127_2591960_3 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003493 267.0
SHD2_k127_2591960_4 hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000002054 133.0
SHD2_k127_2591960_5 Dodecin K09165 - - 0.000000000000000000007456 93.0
SHD2_k127_2591960_6 cellulase activity - - - 0.000004306 55.0
SHD2_k127_2597755_0 Glycine betaine K05845 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 357.0
SHD2_k127_2625865_0 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 496.0
SHD2_k127_2625865_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000003135 208.0
SHD2_k127_2625865_2 Carotenoid biosynthesis protein - - - 0.000000000000000000000000000000000000000001865 160.0
SHD2_k127_2663712_0 MBOAT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 580.0
SHD2_k127_2663712_1 - - - - 0.0000000000156 71.0
SHD2_k127_2663712_2 Glycosyl transferases group 1 - - - 0.000005109 55.0
SHD2_k127_2671427_0 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 6.491e-301 930.0
SHD2_k127_2671427_1 Carboxyl transferase domain - - - 1.214e-269 841.0
SHD2_k127_2671427_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 1.806e-246 774.0
SHD2_k127_2671427_3 Acyclic terpene utilisation family protein AtuA - - - 2.247e-199 626.0
SHD2_k127_2671427_4 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 493.0
SHD2_k127_2671427_5 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 458.0
SHD2_k127_2671427_6 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 391.0
SHD2_k127_2671427_7 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000102 239.0
SHD2_k127_2671427_8 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000001638 142.0
SHD2_k127_2674270_0 WD40-like Beta Propeller Repeat - - - 5.416e-306 968.0
SHD2_k127_2674270_1 Amidohydrolase family - - - 1.246e-224 708.0
SHD2_k127_2674270_10 - - - - 0.0000002274 60.0
SHD2_k127_2674270_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 518.0
SHD2_k127_2674270_3 NAD(P)H quinone oxidoreductase, PIG3 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 325.0
SHD2_k127_2674270_4 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000001217 234.0
SHD2_k127_2674270_5 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000007648 214.0
SHD2_k127_2674270_6 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000003063 201.0
SHD2_k127_2674270_7 - - - - 0.0000000000000000000000000000001887 128.0
SHD2_k127_2674270_8 - - - - 0.000000000000000000003657 101.0
SHD2_k127_2674270_9 Protein kinase domain K12132 - 2.7.11.1 0.000000000000001956 77.0
SHD2_k127_2703345_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1731.0
SHD2_k127_2703345_1 Hexapeptide repeat of succinyl-transferase K13018 - 2.3.1.201 0.0000000000000000000001958 98.0
SHD2_k127_27057_0 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000001769 214.0
SHD2_k127_27057_1 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000001301 214.0
SHD2_k127_27057_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0003436 51.0
SHD2_k127_2759157_0 COG0433 Predicted ATPase K06915 - - 1.031e-310 963.0
SHD2_k127_2759157_1 AAA domain K03546 - - 3.062e-218 704.0
SHD2_k127_2759157_10 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000007567 220.0
SHD2_k127_2759157_11 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000006472 209.0
SHD2_k127_2759157_12 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000006853 193.0
SHD2_k127_2759157_13 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000000000003493 137.0
SHD2_k127_2759157_14 - - - - 0.00000000000000000000000000007101 123.0
SHD2_k127_2759157_15 - - - - 0.0000000000000000000000007369 115.0
SHD2_k127_2759157_16 - - - - 0.0000000001271 64.0
SHD2_k127_2759157_2 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 525.0
SHD2_k127_2759157_3 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 437.0
SHD2_k127_2759157_4 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003398 391.0
SHD2_k127_2759157_5 Thymidine kinase K00857 - 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 317.0
SHD2_k127_2759157_6 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 292.0
SHD2_k127_2759157_7 COGs COG2380 conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002094 275.0
SHD2_k127_2759157_8 DbpA RNA binding domain K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000008947 267.0
SHD2_k127_2759157_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000000000000000000000002307 234.0
SHD2_k127_2831509_0 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008734 606.0
SHD2_k127_2831509_1 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009358 530.0
SHD2_k127_2831509_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 378.0
SHD2_k127_2831509_3 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000003141 244.0
SHD2_k127_2831509_4 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000002711 170.0
SHD2_k127_2831509_5 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000000000000000001035 169.0
SHD2_k127_2831509_6 Cold shock K03704 - - 0.0000000000000000000000000000002968 124.0
SHD2_k127_2840147_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 3294.0
SHD2_k127_2840147_1 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 3.322e-318 985.0
SHD2_k127_2840147_10 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000000000000000000000000002399 206.0
SHD2_k127_2840147_11 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000003543 205.0
SHD2_k127_2840147_12 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000002512 135.0
SHD2_k127_2840147_13 Membrane - - - 0.000000000000000000000000000005605 136.0
SHD2_k127_2840147_15 diguanylate cyclase activity K13069 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.00000005855 57.0
SHD2_k127_2840147_2 Glycine D-amino acid oxidase (deaminating) - - - 2.342e-199 634.0
SHD2_k127_2840147_3 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 480.0
SHD2_k127_2840147_4 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 379.0
SHD2_k127_2840147_5 palmitoyl-(protein) hydrolase activity K06999,K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 364.0
SHD2_k127_2840147_6 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 357.0
SHD2_k127_2840147_7 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003915 286.0
SHD2_k127_2840147_8 OmpA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001999 252.0
SHD2_k127_2840147_9 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000001263 211.0
SHD2_k127_2850222_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004189 273.0
SHD2_k127_2850222_1 CheC-like family K03410 - - 0.000000000000000000000000000000000000000000000524 174.0
SHD2_k127_2850222_2 heat shock protein binding - - - 0.0000000000000000000000000000000003953 143.0
SHD2_k127_2850222_3 P2 response regulator binding domain K03407 - 2.7.13.3 0.00002191 47.0
SHD2_k127_2868362_0 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 368.0
SHD2_k127_2868362_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 367.0
SHD2_k127_2868362_2 Alpha/beta hydrolase family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 360.0
SHD2_k127_2868362_3 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000543 261.0
SHD2_k127_2868362_4 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000032 184.0
SHD2_k127_2868362_5 - - - - 0.000000000000000000000000000000005902 136.0
SHD2_k127_2868362_6 Domain present in PSD-95, Dlg, and ZO-1/2. K04771 - 3.4.21.107 0.00000000000000000000001446 110.0
SHD2_k127_2869717_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 581.0
SHD2_k127_2869717_1 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 369.0
SHD2_k127_2869717_2 Enoyl-CoA hydratase/isomerase K13766 - 4.2.1.18 0.0000000000000000000000000000000000001257 145.0
SHD2_k127_2924286_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 7.368e-197 625.0
SHD2_k127_2924286_1 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 436.0
SHD2_k127_2924286_2 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 365.0
SHD2_k127_2924286_3 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 357.0
SHD2_k127_2924286_4 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000000000000002938 222.0
SHD2_k127_2924286_5 Protein of unknown function (DUF721) - - - 0.0000000000000000000001653 102.0
SHD2_k127_2954686_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007914 595.0
SHD2_k127_2954686_1 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000008645 203.0
SHD2_k127_3058907_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 5.049e-233 727.0
SHD2_k127_3058907_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 5.102e-226 708.0
SHD2_k127_3080493_0 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 537.0
SHD2_k127_3080493_1 - - - - 0.00000000008665 66.0
SHD2_k127_314345_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.855e-265 823.0
SHD2_k127_314345_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 434.0
SHD2_k127_314345_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K00950,K01633 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.81,2.5.1.15,2.7.6.3,4.1.2.25,5.1.99.8 0.00000000000000000000000000000000000000000000000000000000000000000000009225 252.0
SHD2_k127_31575_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 353.0
SHD2_k127_31575_1 Zinc carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001452 280.0
SHD2_k127_3171605_0 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009945 466.0
SHD2_k127_3171605_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000008104 177.0
SHD2_k127_3178030_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 494.0
SHD2_k127_3178030_1 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 475.0
SHD2_k127_3178030_2 Predicted membrane protein (DUF2238) K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000002131 239.0
SHD2_k127_3178030_3 LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000001895 223.0
SHD2_k127_3178030_4 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000000001422 186.0
SHD2_k127_3178030_5 - - - - 0.00000000000000000000000000000000000001316 147.0
SHD2_k127_3178030_6 Amidohydrolase K07045 - - 0.0000000000001006 72.0
SHD2_k127_3188415_0 Lysylphosphatidylglycerol synthase TM region K07027,K14205 - 2.3.2.3 2.369e-245 780.0
SHD2_k127_3188415_1 Deoxyhypusine synthase K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 575.0
SHD2_k127_3188415_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 413.0
SHD2_k127_3188415_3 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000000000000000000000000000313 196.0
SHD2_k127_3188415_4 mechanosensitive ion channel activity K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000003175 115.0
SHD2_k127_3188415_5 COG NOG06100 non supervised orthologous group - - - 0.000002466 59.0
SHD2_k127_3189550_0 cellulose binding - - - 5e-324 1010.0
SHD2_k127_3189550_1 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 399.0
SHD2_k127_3189550_2 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 388.0
SHD2_k127_3189550_3 Biotin-lipoyl like K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 340.0
SHD2_k127_3189550_4 transcriptional regulators - - - 0.000000000000000000005536 98.0
SHD2_k127_3193177_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007695 461.0
SHD2_k127_3193177_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004292 278.0
SHD2_k127_3193177_2 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000004986 153.0
SHD2_k127_3202690_0 DEAD/H associated K03724 - - 0.0 1727.0
SHD2_k127_3202690_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 571.0
SHD2_k127_3202690_10 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000003615 235.0
SHD2_k127_3202690_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000001541 213.0
SHD2_k127_3202690_12 Iron-containing redox enzyme - - - 0.0000000000000000000000000000000000000000000009898 180.0
SHD2_k127_3202690_13 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000001631 163.0
SHD2_k127_3202690_14 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000005079 150.0
SHD2_k127_3202690_15 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000691 138.0
SHD2_k127_3202690_16 Acyl-transferase K00655 - 2.3.1.51 0.000000000000000000000000007216 121.0
SHD2_k127_3202690_17 - - - - 0.000000000000000000000003706 105.0
SHD2_k127_3202690_18 Anti-sigma-K factor rskA - - - 0.00000000005645 74.0
SHD2_k127_3202690_19 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000004072 68.0
SHD2_k127_3202690_2 Phosphoribosylglycinamide synthetase, C domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004455 548.0
SHD2_k127_3202690_3 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 521.0
SHD2_k127_3202690_4 Replication initiator protein A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 372.0
SHD2_k127_3202690_5 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 363.0
SHD2_k127_3202690_6 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001645 284.0
SHD2_k127_3202690_7 MerR HTH family regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001103 254.0
SHD2_k127_3202690_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005158 255.0
SHD2_k127_3202690_9 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000008919 243.0
SHD2_k127_3212379_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1246.0
SHD2_k127_3212379_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 583.0
SHD2_k127_3212379_10 PAP2 superfamily - - - 0.00007119 53.0
SHD2_k127_3212379_2 asparaginase activity K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 423.0
SHD2_k127_3212379_3 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 393.0
SHD2_k127_3212379_4 Uncharacterised protein family UPF0102 K07460 - - 0.00000000000000000000000000001129 122.0
SHD2_k127_3212379_5 Modulates RecA activity K03565 - - 0.00000000000000000000000003294 115.0
SHD2_k127_3212379_6 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0000000000000000000613 89.0
SHD2_k127_3212379_8 - - - - 0.0000127 51.0
SHD2_k127_3212379_9 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00005545 54.0
SHD2_k127_3219538_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 2.785e-213 669.0
SHD2_k127_3219538_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 401.0
SHD2_k127_3219538_2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 393.0
SHD2_k127_3219538_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000005264 220.0
SHD2_k127_3219538_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000004201 202.0
SHD2_k127_3219538_5 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000001598 168.0
SHD2_k127_3219538_6 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000262 167.0
SHD2_k127_3219538_7 Glycosyltransferase, group 2 family protein - - - 0.000000000000000000000000000000001109 140.0
SHD2_k127_3223136_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 559.0
SHD2_k127_3223136_1 Uncharacterised protein family (UPF0182) K09118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009411 321.0
SHD2_k127_3223136_2 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000002832 108.0
SHD2_k127_3229619_0 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 414.0
SHD2_k127_3229619_1 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001329 249.0
SHD2_k127_3229619_2 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.000000000000000000000000000000000000000002336 169.0
SHD2_k127_3229619_3 thioesterase' K07107 - - 0.00000006922 59.0
SHD2_k127_3235168_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1329.0
SHD2_k127_3235168_1 Acetamidase/Formamidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 410.0
SHD2_k127_3235168_10 cellulose binding - - - 0.000000000000000000000000000000001772 142.0
SHD2_k127_3235168_11 Carboxypeptidase regulatory-like domain - - - 0.000000000000000001461 101.0
SHD2_k127_3235168_12 Recombinase zinc beta ribbon domain - - - 0.00002618 48.0
SHD2_k127_3235168_2 Elongation factor SelB winged helix 3 K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 401.0
SHD2_k127_3235168_3 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001237 269.0
SHD2_k127_3235168_4 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001713 246.0
SHD2_k127_3235168_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000002937 220.0
SHD2_k127_3235168_6 choline dehydrogenase activity K03333 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016614,GO:0016899,GO:0016995,GO:0044419,GO:0051704,GO:0055114 1.1.3.6 0.0000000000000000000000000000000000000000000000000000000000002423 217.0
SHD2_k127_3235168_7 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000000000000000000000000000000000000000261 191.0
SHD2_k127_3235168_8 Carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000003368 184.0
SHD2_k127_3235168_9 cobalamin-transporting ATPase activity K02014,K16092 - - 0.00000000000000000000000000000000000000000000003014 180.0
SHD2_k127_3235864_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 580.0
SHD2_k127_3235864_1 Protein kinase domain K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004064 430.0
SHD2_k127_3235864_2 methylamine metabolic process K15977 - - 0.0000000000000000000000000000000000000000006265 163.0
SHD2_k127_3235864_3 DNA-binding transcription factor activity - - - 0.0002152 45.0
SHD2_k127_3251639_0 cell redox homeostasis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 443.0
SHD2_k127_3251639_1 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 373.0
SHD2_k127_3251639_2 Aldo Keto reductase K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 375.0
SHD2_k127_3251639_3 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 294.0
SHD2_k127_3251639_4 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000007458 231.0
SHD2_k127_3251639_5 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000005412 214.0
SHD2_k127_3251639_6 - - - - 0.0000000000000000000000000000000000000001044 157.0
SHD2_k127_3251639_7 cell redox homeostasis - - - 0.000000000000002603 78.0
SHD2_k127_3251639_8 crp fnr family K21564 - - 0.00008953 53.0
SHD2_k127_3252444_0 FtsX-like permease family K02004 - - 2.791e-225 722.0
SHD2_k127_3252444_1 E1-E2 ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 544.0
SHD2_k127_3252444_10 COGs COG2823 periplasmic or secreted lipoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000004494 221.0
SHD2_k127_3252444_11 CYTH K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000002771 212.0
SHD2_k127_3252444_12 - - - - 0.000000000000000000000000000000000000000005964 163.0
SHD2_k127_3252444_13 Belongs to the universal stress protein A family - - - 0.0000000000000000000000000000000000000001637 162.0
SHD2_k127_3252444_14 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000005422 155.0
SHD2_k127_3252444_15 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000001082 148.0
SHD2_k127_3252444_16 Ppx/GppA phosphatase family - - - 0.0000000000000000000000000001144 125.0
SHD2_k127_3252444_17 Yip1 domain - - - 0.0000000000000000000000000248 118.0
SHD2_k127_3252444_18 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000005182 119.0
SHD2_k127_3252444_19 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000002808 104.0
SHD2_k127_3252444_2 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 363.0
SHD2_k127_3252444_20 Family of unknown function (DUF5335) - - - 0.0000000000000000002564 96.0
SHD2_k127_3252444_21 AMP binding - - - 0.0000000000001653 81.0
SHD2_k127_3252444_22 Histidine kinase - - - 0.000000001412 61.0
SHD2_k127_3252444_23 BON domain - - - 0.00000000223 68.0
SHD2_k127_3252444_24 Belongs to the universal stress protein A family - - - 0.0000001667 63.0
SHD2_k127_3252444_25 Universal stress protein family - - - 0.000004398 58.0
SHD2_k127_3252444_26 Belongs to the universal stress protein A family - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0006466 48.0
SHD2_k127_3252444_3 Di- and tricarboxylate transporters - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 368.0
SHD2_k127_3252444_4 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 341.0
SHD2_k127_3252444_5 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 336.0
SHD2_k127_3252444_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 308.0
SHD2_k127_3252444_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001685 279.0
SHD2_k127_3252444_8 Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007366 267.0
SHD2_k127_3252444_9 helix_turn_helix, Lux Regulon K02282,K07696 - - 0.000000000000000000000000000000000000000000000000000000000000000003093 237.0
SHD2_k127_3254524_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1227.0
SHD2_k127_3254524_1 Peptidase M14, carboxypeptidase A - - - 0.0 1172.0
SHD2_k127_3254524_10 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003347 245.0
SHD2_k127_3254524_11 - K07274 - - 0.000000000000000000000000000000000000000000000000000000000000000000723 243.0
SHD2_k127_3254524_12 BON domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005267 229.0
SHD2_k127_3254524_13 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000001459 206.0
SHD2_k127_3254524_14 Gluconate 2-dehydrogenase subunit 3 - - - 0.0000000000000000000000000000000000000000000000000005266 191.0
SHD2_k127_3254524_15 HAD-hyrolase-like K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000003727 164.0
SHD2_k127_3254524_16 HNH nucleases - - - 0.000000000001505 76.0
SHD2_k127_3254524_2 GMC oxidoreductase - - - 2.514e-296 916.0
SHD2_k127_3254524_3 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.442e-235 743.0
SHD2_k127_3254524_4 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 1.224e-232 732.0
SHD2_k127_3254524_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 594.0
SHD2_k127_3254524_6 Nucleoside H+ symporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 497.0
SHD2_k127_3254524_7 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042,K17468 - 2.9.1.1,4.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 432.0
SHD2_k127_3254524_8 PFAM glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 340.0
SHD2_k127_3254524_9 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005323 250.0
SHD2_k127_3258048_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.364e-296 920.0
SHD2_k127_3258048_1 May be involved in recombinational repair of damaged DNA K03631 - - 5.577e-229 721.0
SHD2_k127_3258048_2 glucan 1,4-alpha-glucosidase activity - - - 5.371e-212 677.0
SHD2_k127_3258048_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008258 349.0
SHD2_k127_3260898_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 503.0
SHD2_k127_3274345_0 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 422.0
SHD2_k127_3274345_1 Disulphide bond corrector protein DsbC K04084 - 1.8.1.8 0.000000000000000005225 90.0
SHD2_k127_3274345_2 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000004867 83.0
SHD2_k127_3274345_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000002278 91.0
SHD2_k127_3274345_4 amino acid activation for nonribosomal peptide biosynthetic process K05996 - 3.4.17.18 0.0000000000000007524 83.0
SHD2_k127_3276270_0 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 543.0
SHD2_k127_3276270_1 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 469.0
SHD2_k127_3276270_2 DinB superfamily - - - 0.00000000000000000000000000000000009748 134.0
SHD2_k127_3304328_0 RecQ zinc-binding K03654 - 3.6.4.12 2.753e-208 660.0
SHD2_k127_3304328_1 Putative RNA methylase family UPF0020 K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 323.0
SHD2_k127_3304328_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00006582 50.0
SHD2_k127_3321652_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000005637 255.0
SHD2_k127_3321652_1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000002679 226.0
SHD2_k127_3321652_2 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000007575 84.0
SHD2_k127_3326765_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 497.0
SHD2_k127_3326765_1 Helix-hairpin-helix motif K02337 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 389.0
SHD2_k127_3326765_2 PSP1 C-terminal conserved region - - - 0.00000000000000000007758 90.0
SHD2_k127_3329128_0 PFAM Enoyl-CoA hydratase isomerase - - - 6.404e-225 717.0
SHD2_k127_3329128_1 benzoyl-CoA reductase K04112 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009777 425.0
SHD2_k127_3329128_2 - - - - 0.000000000000000000000000000000000000000000000000000002449 205.0
SHD2_k127_3329128_3 COG0840 Methyl-accepting chemotaxis protein - - - 0.00000000000000000000000000000000000000000000000000004248 198.0
SHD2_k127_3329128_4 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000007939 137.0
SHD2_k127_3337248_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 570.0
SHD2_k127_3337248_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 539.0
SHD2_k127_3337248_2 cellular response to dsDNA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002537 264.0
SHD2_k127_3337248_3 PFAM phospholipase Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000004164 216.0
SHD2_k127_3337248_4 AraC-like ligand binding domain - - - 0.00000000000000000000000000000000000000000000000001849 189.0
SHD2_k127_3337248_5 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000283 118.0
SHD2_k127_3337248_6 Protein of unknown function (DUF3037) - - - 0.00000000000000000000000000003229 123.0
SHD2_k127_3337248_7 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000722 117.0
SHD2_k127_3340027_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.399e-292 917.0
SHD2_k127_3340027_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 596.0
SHD2_k127_3340027_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006777 546.0
SHD2_k127_3340027_3 Nucleotidyl transferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 452.0
SHD2_k127_3340027_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 412.0
SHD2_k127_3340027_5 Sugar nucleotidyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 349.0
SHD2_k127_3340027_6 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000002985 186.0
SHD2_k127_3340027_7 Roadblock/LC7 domain K07131 - - 0.000000000000000000000002551 106.0
SHD2_k127_3340027_8 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000005006 105.0
SHD2_k127_3340027_9 - - - - 0.00000000000000000000008804 111.0
SHD2_k127_3343181_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 1.23e-320 990.0
SHD2_k127_3343181_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 335.0
SHD2_k127_3343181_2 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000002892 238.0
SHD2_k127_3343181_3 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000000000005218 209.0
SHD2_k127_3343181_4 Flp pilus assembly protein CpaB K02279 - - 0.00000000000000000000000000000000000000000000002608 175.0
SHD2_k127_3343181_5 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000001685 119.0
SHD2_k127_3343181_6 - - - - 0.0000000000000000000000000005783 126.0
SHD2_k127_3343181_7 aspartic-type endopeptidase activity K02278,K02654 - 3.4.23.43 0.00000000000000000000000379 108.0
SHD2_k127_3343181_8 Flp Fap pilin component K02651 - - 0.00008456 46.0
SHD2_k127_3343181_9 Flp/Fap pilin component K02651 - - 0.0001958 47.0
SHD2_k127_3363864_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1220.0
SHD2_k127_3363864_1 Fumarase C C-terminus K01744 - 4.3.1.1 7.109e-232 725.0
SHD2_k127_3363864_2 asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 452.0
SHD2_k127_3363864_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000002806 192.0
SHD2_k127_3363864_4 histidine kinase HAMP region domain protein K03406 - - 0.000000000000000000000003196 119.0
SHD2_k127_3363864_5 cellular manganese ion homeostasis - - - 0.00000000000002944 73.0
SHD2_k127_3387580_0 DNA polymerase alpha chain like domain K02347 - - 3.49e-200 638.0
SHD2_k127_3387580_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 458.0
SHD2_k127_3387580_2 M42 glutamyl aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 417.0
SHD2_k127_3387580_3 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007382 403.0
SHD2_k127_3387580_4 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 325.0
SHD2_k127_3387580_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000007625 245.0
SHD2_k127_3387580_6 - - - - 0.0000000000000000000000000000001134 130.0
SHD2_k127_3408105_0 Aromatic amino acid lyase K01745 - 4.3.1.3 1.741e-216 682.0
SHD2_k127_3408105_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0000000000000000000000000000000000000000002181 161.0
SHD2_k127_3408105_2 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.000000000000000000001428 94.0
SHD2_k127_3436793_0 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 346.0
SHD2_k127_3436793_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 296.0
SHD2_k127_3436793_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000005353 215.0
SHD2_k127_3436793_3 - - - - 0.0000000004152 66.0
SHD2_k127_3439481_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0 1365.0
SHD2_k127_3439481_1 protein histidine kinase activity - - - 5.31e-196 625.0
SHD2_k127_3439481_10 Cupin 2, conserved barrel - - - 0.0000000000000000000000000000000000000000000000004549 194.0
SHD2_k127_3439481_11 - - - - 0.000000000000000000000000000006308 128.0
SHD2_k127_3439481_12 - - - - 0.000000000000000000000007722 113.0
SHD2_k127_3439481_13 Uncharacterised conserved protein (DUF2156) K14205 - 2.3.2.3 0.00000000000000000001465 100.0
SHD2_k127_3439481_14 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000002905 99.0
SHD2_k127_3439481_2 AAA ATPase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 646.0
SHD2_k127_3439481_3 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004302 561.0
SHD2_k127_3439481_4 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 308.0
SHD2_k127_3439481_5 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 309.0
SHD2_k127_3439481_6 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000000002716 229.0
SHD2_k127_3439481_7 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000004679 241.0
SHD2_k127_3439481_8 UPF0126 domain - - - 0.000000000000000000000000000000000000000000000000000000003612 205.0
SHD2_k127_3439481_9 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000003473 215.0
SHD2_k127_3439997_0 RecQ zinc-binding K03654 - 3.6.4.12 4.198e-266 835.0
SHD2_k127_3492204_0 PFAM iron-containing alcohol dehydrogenase K00217 - 1.3.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 356.0
SHD2_k127_3492204_1 succinyl-diaminopimelate desuccinylase activity K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 342.0
SHD2_k127_3492204_2 Domain of unknown function (DUF1906) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 300.0
SHD2_k127_3492204_3 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 283.0
SHD2_k127_3492204_4 glucose sorbosone - - - 0.000000000000000000000000000000553 133.0
SHD2_k127_352505_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1480.0
SHD2_k127_352505_1 ABC transporter transmembrane region K18890 - - 2.434e-230 729.0
SHD2_k127_352505_2 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 574.0
SHD2_k127_352505_3 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 323.0
SHD2_k127_352505_4 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000006706 253.0
SHD2_k127_352505_5 Transglycosylase associated protein - - - 0.00000000000000000000000000215 115.0
SHD2_k127_352505_6 Transglycosylase associated protein - - - 0.0000000000000000002326 90.0
SHD2_k127_352505_7 - - - - 0.0000000000003813 75.0
SHD2_k127_352505_8 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000005691 63.0
SHD2_k127_352591_0 domain protein K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 506.0
SHD2_k127_352591_1 Zinc carboxypeptidase K14054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001165 265.0
SHD2_k127_352591_2 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000002211 258.0
SHD2_k127_352591_3 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000002086 191.0
SHD2_k127_352591_4 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00008238 49.0
SHD2_k127_355414_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1080.0
SHD2_k127_355414_1 4Fe-4S binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 379.0
SHD2_k127_355414_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 390.0
SHD2_k127_355414_3 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 379.0
SHD2_k127_355414_4 - K00241 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001961 244.0
SHD2_k127_355414_5 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00002161 46.0
SHD2_k127_355414_6 guanyl-nucleotide exchange factor activity K05349,K13735,K18491,K20276 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.2.1.21 0.00006917 55.0
SHD2_k127_3583700_0 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006052 444.0
SHD2_k127_3583700_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 391.0
SHD2_k127_3583700_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000001951 236.0
SHD2_k127_3584926_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 528.0
SHD2_k127_3584926_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 300.0
SHD2_k127_3584926_2 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007381 262.0
SHD2_k127_3590070_0 Binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000000000000000000000000000003547 226.0
SHD2_k127_3590070_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000001161 225.0
SHD2_k127_3590070_2 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000000000002404 171.0
SHD2_k127_3590070_3 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000001798 71.0
SHD2_k127_3594477_0 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 376.0
SHD2_k127_3594477_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000007587 190.0
SHD2_k127_3602016_0 Domain of unknown function (DUF5118) - - - 3.95e-255 811.0
SHD2_k127_3602016_1 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 508.0
SHD2_k127_3602016_2 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 471.0
SHD2_k127_3602016_3 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008951 349.0
SHD2_k127_3602016_4 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 319.0
SHD2_k127_3602016_5 diguanylate cyclase activity K13069 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000003322 226.0
SHD2_k127_3602016_6 2'-5' RNA ligase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000002922 218.0
SHD2_k127_3602016_7 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.00000000000000000000000000000000000000000000001215 181.0
SHD2_k127_3602016_8 - - - - 0.000000000000000000000000000000000000000000003201 173.0
SHD2_k127_3610336_0 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 561.0
SHD2_k127_3610336_1 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 473.0
SHD2_k127_3610336_2 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 291.0
SHD2_k127_3610336_3 Pyridoxamine 5'-phosphate oxidase like - - - 0.00000000000000000000000000003991 123.0
SHD2_k127_3674508_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005144 278.0
SHD2_k127_3674508_1 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004017 273.0
SHD2_k127_3674508_2 - - - - 0.00000000000000000000000002839 118.0
SHD2_k127_3689708_0 nitrous-oxide reductase activity K00376,K02275 GO:0000041,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0008150,GO:0015677,GO:0030001,GO:0042597,GO:0044464,GO:0051179,GO:0051234 1.7.2.4,1.9.3.1 8.364e-317 981.0
SHD2_k127_3689708_1 Putative modulator of DNA gyrase K03568 - - 2.234e-235 739.0
SHD2_k127_3689708_10 Belongs to the bacterial solute-binding protein 9 family - - - 0.0000000000000000000000000000000000000000000000000000000001862 220.0
SHD2_k127_3689708_11 ABC-2 family transporter protein K19341 - - 0.0000000000000000000000000000000000000000000000000000000003205 212.0
SHD2_k127_3689708_12 lipoprotein involved in nitrous oxide reduction - - - 0.0000000000000000000000000000000000000000000000003494 198.0
SHD2_k127_3689708_13 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.00000000000000000000000000000000000000001251 157.0
SHD2_k127_3689708_14 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.000000000000000000000000000000006427 133.0
SHD2_k127_3689708_15 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000008326 74.0
SHD2_k127_3689708_2 Putative modulator of DNA gyrase - - - 3.738e-200 634.0
SHD2_k127_3689708_3 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 490.0
SHD2_k127_3689708_4 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 452.0
SHD2_k127_3689708_5 Periplasmic copper-binding protein (NosD) K07218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 386.0
SHD2_k127_3689708_6 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005615 259.0
SHD2_k127_3689708_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002326 252.0
SHD2_k127_3689708_8 ATPase activity K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000324 239.0
SHD2_k127_3689708_9 Cytochrome C and Quinol oxidase polypeptide I - - - 0.0000000000000000000000000000000000000000000000000000000001219 207.0
SHD2_k127_37004_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007538 572.0
SHD2_k127_37004_1 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 399.0
SHD2_k127_37004_2 response regulator K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000003934 240.0
SHD2_k127_37004_3 DinB superfamily - - - 0.00000000000000000000000000004675 124.0
SHD2_k127_3714099_0 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 406.0
SHD2_k127_3726527_0 Pfam:SusD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 490.0
SHD2_k127_3726527_1 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 443.0
SHD2_k127_3726527_2 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004401 261.0
SHD2_k127_3726527_3 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000002331 115.0
SHD2_k127_3726527_4 - - - - 0.00000000000000003053 91.0
SHD2_k127_3739593_0 Prolyl oligopeptidase - - - 2.212e-225 722.0
SHD2_k127_3739593_1 FAD binding domain K07077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 453.0
SHD2_k127_3739593_2 YGGT family K02221 - - 0.000000000000000000000000000000000000000000000000000004231 198.0
SHD2_k127_3739593_3 Belongs to the UPF0235 family K09131 - - 0.00000000000000000001881 99.0
SHD2_k127_3763869_0 Major Facilitator Superfamily - - - 2.505e-199 629.0
SHD2_k127_3763869_1 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 578.0
SHD2_k127_3763869_2 copper resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 364.0
SHD2_k127_3763869_3 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 306.0
SHD2_k127_3763869_4 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000002596 223.0
SHD2_k127_3763869_5 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000001015 224.0
SHD2_k127_3763869_6 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000001725 204.0
SHD2_k127_3763869_7 Helix-hairpin-helix domain K04477 - - 0.000000000000000000000000000000000000000000000000003464 190.0
SHD2_k127_3770569_0 GDP-mannose 4,6 dehydratase - - - 0.0000000000000000000000000000000000000001038 158.0
SHD2_k127_3770569_1 O-acyltransferase activity K00661 - 2.3.1.79 0.000000000000000000000000000000000000001137 155.0
SHD2_k127_3770569_3 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.00002014 57.0
SHD2_k127_3772240_0 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 384.0
SHD2_k127_3772240_1 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000005189 229.0
SHD2_k127_3772240_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000001612 192.0
SHD2_k127_3772240_3 Protein of unknown function (DUF418) K07148 - - 0.000000000000000000000000000000005479 142.0
SHD2_k127_3772240_4 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000006973 130.0
SHD2_k127_3772240_5 Ribosomal protein L36 K02919 - - 0.000000000000008306 76.0
SHD2_k127_37833_0 protein kinase activity K12132 - 2.7.11.1 2.187e-206 667.0
SHD2_k127_37833_1 Cytochrome c-type biogenesis protein K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 602.0
SHD2_k127_37833_10 protein possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000004346 176.0
SHD2_k127_37833_11 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000000008477 180.0
SHD2_k127_37833_12 ABC-type transport system involved in cytochrome c biogenesis permease component K02194 - - 0.0000000000000000000000000000000000001183 150.0
SHD2_k127_37833_13 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000000001324 143.0
SHD2_k127_37833_14 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000002333 140.0
SHD2_k127_37833_15 DinB family - - - 0.0000000000000000000000000000000005856 136.0
SHD2_k127_37833_16 PFAM DsrC family protein K11179 - - 0.000000000000000000000000000000001491 135.0
SHD2_k127_37833_17 subunit of a heme lyase K02198,K02200 - - 0.000000000000000000000002627 108.0
SHD2_k127_37833_18 - - - - 0.00000000000000008903 89.0
SHD2_k127_37833_2 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 595.0
SHD2_k127_37833_3 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 571.0
SHD2_k127_37833_4 pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 500.0
SHD2_k127_37833_5 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 502.0
SHD2_k127_37833_6 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells K03649 - 3.2.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000003803 242.0
SHD2_k127_37833_7 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001592 241.0
SHD2_k127_37833_8 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 0.0000000000000000000000000000000000000000000000000000000000000001239 224.0
SHD2_k127_37833_9 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000001526 216.0
SHD2_k127_3817775_0 FAD linked oxidases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009989 598.0
SHD2_k127_3817775_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009224 412.0
SHD2_k127_3817775_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 340.0
SHD2_k127_3817775_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000278 187.0
SHD2_k127_3817775_4 - - - - 0.0000000000000000000000000000000000000000000000001264 187.0
SHD2_k127_3848241_0 DegT/DnrJ/EryC1/StrS aminotransferase family K18653 GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009987,GO:0016740,GO:0016769,GO:0016999,GO:0017000,GO:0017144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 471.0
SHD2_k127_3848241_1 Alternative locus ID K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 410.0
SHD2_k127_3848241_10 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) - - - 0.0000000000000196 85.0
SHD2_k127_3848241_2 Transketolase, thiamine diphosphate binding domain K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 405.0
SHD2_k127_3848241_3 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 305.0
SHD2_k127_3848241_4 undecaprenyl-phosphate glucose phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002643 264.0
SHD2_k127_3848241_5 Capsule assembly protein Wzi - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007948 260.0
SHD2_k127_3848241_6 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000000000000000000000000000000000000000008642 226.0
SHD2_k127_3848241_7 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000117 217.0
SHD2_k127_3848241_8 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000001169 187.0
SHD2_k127_3848241_9 PFAM glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000001764 136.0
SHD2_k127_3872417_0 Belongs to the thiolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006201 394.0
SHD2_k127_3872417_1 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.0000000000000000000000000000000000005015 141.0
SHD2_k127_3873931_0 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 381.0
SHD2_k127_3873931_1 PPIC-type PPIASE domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 319.0
SHD2_k127_3873931_2 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000001031 181.0
SHD2_k127_3897785_0 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 410.0
SHD2_k127_3897785_1 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 374.0
SHD2_k127_3897785_2 Capsule assembly protein Wzi - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 339.0
SHD2_k127_3897785_3 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 322.0
SHD2_k127_3897785_4 Capsule assembly protein Wzi - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001474 293.0
SHD2_k127_3897785_5 undecaprenyl-phosphate glucose phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006404 286.0
SHD2_k127_3897785_6 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000007951 209.0
SHD2_k127_3897785_7 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000003385 57.0
SHD2_k127_3901074_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 3.094e-220 697.0
SHD2_k127_3901074_1 Putative modulator of DNA gyrase - - - 1.065e-195 622.0
SHD2_k127_3901074_2 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000174 147.0
SHD2_k127_3917353_0 CarboxypepD_reg-like domain - - - 3.471e-237 764.0
SHD2_k127_3917353_1 Gram-negative bacterial TonB protein C-terminal - - - 0.00000000000000000000000000000000000000000000000000001743 205.0
SHD2_k127_3917353_2 Helix-hairpin-helix motif K02337 - 2.7.7.7 0.0000000004579 59.0
SHD2_k127_3917353_3 - - - - 0.0000003145 58.0
SHD2_k127_397084_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 4.852e-205 647.0
SHD2_k127_397084_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007287 475.0
SHD2_k127_397084_2 4Fe-4S binding domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 404.0
SHD2_k127_397084_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 366.0
SHD2_k127_397084_4 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 305.0
SHD2_k127_397084_5 FAD binding domain K11472 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004231 287.0
SHD2_k127_397084_6 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000326 226.0
SHD2_k127_397084_7 3D domain protein - - - 0.0000000000000000000000000000000000004821 148.0
SHD2_k127_397084_9 Pyridine nucleotide-disulphide oxidoreductase K21567 - 1.18.1.2,1.19.1.1 0.00000001333 56.0
SHD2_k127_399230_0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 492.0
SHD2_k127_399230_1 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007911 265.0
SHD2_k127_399230_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000005459 229.0
SHD2_k127_399230_3 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000238 162.0
SHD2_k127_399418_0 Thiolase, C-terminal domain K00632 - 2.3.1.16 5.904e-202 636.0
SHD2_k127_399418_1 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 465.0
SHD2_k127_399418_2 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 428.0
SHD2_k127_399418_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 346.0
SHD2_k127_399418_4 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000112 241.0
SHD2_k127_399418_5 Transcription elongation factor, N-terminal K03624 - - 0.000000000000000000000000000000000000000000000000000000000000003908 223.0
SHD2_k127_4020941_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 6.643e-296 917.0
SHD2_k127_4020941_1 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 559.0
SHD2_k127_4020941_2 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009589 530.0
SHD2_k127_4020941_3 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 363.0
SHD2_k127_4020941_4 Cytochrome c oxidase subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 357.0
SHD2_k127_4020941_5 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008262 290.0
SHD2_k127_4020941_6 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000000000000009648 205.0
SHD2_k127_4020941_7 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.00000000000000000000000000000000001646 138.0
SHD2_k127_4020941_8 - - - - 0.00000000000000000000000000000000006745 139.0
SHD2_k127_4020941_9 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000001036 75.0
SHD2_k127_4031026_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 2.719e-198 626.0
SHD2_k127_4031026_1 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.000000000000000000000000000000000000000000003461 175.0
SHD2_k127_4038871_0 COG0574 Phosphoenolpyruvate synthase pyruvate phosphate dikinase K01007,K21787 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016999,GO:0017000,GO:0017144,GO:0044237,GO:0044249 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 511.0
SHD2_k127_4038871_1 acetyltransferase - GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000004053 158.0
SHD2_k127_4040830_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 394.0
SHD2_k127_4040830_1 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004995 373.0
SHD2_k127_4053599_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1131.0
SHD2_k127_4053599_1 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 1.058e-217 684.0
SHD2_k127_4053599_2 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000000000005165 131.0
SHD2_k127_4053599_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000004102 96.0
SHD2_k127_4054056_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 3.665e-214 672.0
SHD2_k127_4054056_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 410.0
SHD2_k127_4054056_2 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 303.0
SHD2_k127_4054056_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004442 307.0
SHD2_k127_4054056_4 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 287.0
SHD2_k127_4054056_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002357 251.0
SHD2_k127_4054056_6 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000004062 196.0
SHD2_k127_4067126_0 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 590.0
SHD2_k127_4067126_1 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 425.0
SHD2_k127_4067126_2 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 396.0
SHD2_k127_4067126_3 glyoxalase III activity K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000001547 203.0
SHD2_k127_4067126_4 YceI-like domain - - - 0.00000000000000006743 89.0
SHD2_k127_4102778_0 Protein kinase domain K12132 - 2.7.11.1 7.466e-213 676.0
SHD2_k127_4102778_1 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 623.0
SHD2_k127_4102778_10 OmpA family K03640 - - 0.00000000000000000000000000000000000003578 162.0
SHD2_k127_4102778_11 - - - - 0.00000000005841 75.0
SHD2_k127_4102778_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 549.0
SHD2_k127_4102778_3 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 483.0
SHD2_k127_4102778_4 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 465.0
SHD2_k127_4102778_5 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 398.0
SHD2_k127_4102778_6 SMART Metal-dependent phosphohydrolase, HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000368 329.0
SHD2_k127_4102778_7 creatininase K01470,K22232 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 291.0
SHD2_k127_4102778_8 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000006805 238.0
SHD2_k127_4102778_9 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000002569 218.0
SHD2_k127_4141323_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1122.0
SHD2_k127_4141323_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 3.565e-210 666.0
SHD2_k127_4141323_10 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000003561 76.0
SHD2_k127_4141323_2 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 427.0
SHD2_k127_4141323_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 394.0
SHD2_k127_4141323_4 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 373.0
SHD2_k127_4141323_5 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000342 244.0
SHD2_k127_4141323_6 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000006475 166.0
SHD2_k127_4141323_7 TatD family K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000001505 167.0
SHD2_k127_4141323_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000001149 151.0
SHD2_k127_4141323_9 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - 0.000000000000000000004 97.0
SHD2_k127_4142091_0 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 320.0
SHD2_k127_4142091_1 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 301.0
SHD2_k127_4142091_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000003588 126.0
SHD2_k127_4142091_3 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000456 93.0
SHD2_k127_4146904_0 Insulinase (Peptidase family M16) K07263 - - 1.484e-250 792.0
SHD2_k127_4146904_1 Amidohydrolase family - - - 3.029e-243 768.0
SHD2_k127_4146904_2 Homoserine dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 452.0
SHD2_k127_4146904_3 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 346.0
SHD2_k127_4146904_4 Domain of unknown function (DUF4105) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008701 344.0
SHD2_k127_41552_0 peptidase K01415,K07386 - 3.4.24.71 2.365e-283 885.0
SHD2_k127_41552_1 AAA ATPase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 622.0
SHD2_k127_41552_10 Uncharacterized conserved protein (DUF2249) - - - 0.0000000000000000000000000000000000008071 140.0
SHD2_k127_41552_11 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.000000000000000000000000000000002001 138.0
SHD2_k127_41552_12 PFAM Protein kinase domain - - - 0.00000000000000000000000000000009385 145.0
SHD2_k127_41552_13 Cupin 2, conserved barrel domain protein - - - 0.000000000000000007164 89.0
SHD2_k127_41552_14 OmpA family - - - 0.000000000000003649 87.0
SHD2_k127_41552_15 Domain of Unknown function (DUF542) K07322 - - 0.00000000002317 67.0
SHD2_k127_41552_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007465 529.0
SHD2_k127_41552_3 Protein of unknown function (DUF3494) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 430.0
SHD2_k127_41552_4 DJ-1/PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007809 268.0
SHD2_k127_41552_5 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000006206 213.0
SHD2_k127_41552_6 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000001701 201.0
SHD2_k127_41552_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000002787 195.0
SHD2_k127_41552_8 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000005575 187.0
SHD2_k127_41552_9 peroxidase activity K00435 - - 0.00000000000000000000000000000000000000000000006572 181.0
SHD2_k127_421063_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.69e-293 915.0
SHD2_k127_421063_1 Heat shock 70 kDa protein K04043 - - 3.347e-206 644.0
SHD2_k127_421063_2 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007843 595.0
SHD2_k127_421063_3 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 482.0
SHD2_k127_421063_4 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000904 337.0
SHD2_k127_421063_5 HAMP domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006292 283.0
SHD2_k127_421063_6 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000001396 236.0
SHD2_k127_421063_7 Bacterial Ig-like domain 2 - - - 0.00002636 58.0
SHD2_k127_4235779_0 transporter - - - 1.779e-261 824.0
SHD2_k127_4235779_1 Dipeptidyl carboxypeptidase K01284 - 3.4.15.5 1.414e-228 720.0
SHD2_k127_4236854_0 Aldehyde dehydrogenase family K00128,K00130 - 1.2.1.3,1.2.1.8 5.223e-239 748.0
SHD2_k127_4236854_1 belongs to the aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 356.0
SHD2_k127_4238701_0 Hypothetical methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 448.0
SHD2_k127_4238701_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K07112 - - 0.000000000001562 70.0
SHD2_k127_4238701_2 Trypsin K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000001468 62.0
SHD2_k127_4247313_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 448.0
SHD2_k127_4247313_1 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000009204 191.0
SHD2_k127_4247313_2 MobA-Related Protein K00087,K07141,K07402,K19190 - 1.1.1.328,1.17.1.4,2.7.7.76 0.0000000000000000000000000000000000000000001488 166.0
SHD2_k127_4247313_3 XdhC and CoxI family - - - 0.000000000000000001621 87.0
SHD2_k127_4254016_0 Cytochrome C and Quinol oxidase polypeptide I K15862 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 451.0
SHD2_k127_4254016_1 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001691 250.0
SHD2_k127_4254016_2 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000001559 140.0
SHD2_k127_4276015_0 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 426.0
SHD2_k127_4276015_1 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000005868 250.0
SHD2_k127_4276015_2 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000008899 171.0
SHD2_k127_4276015_3 Psort location Cytoplasmic, score K00945 - 2.7.4.25 0.00000000000000000000000006149 115.0
SHD2_k127_4290829_0 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 377.0
SHD2_k127_4290829_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 369.0
SHD2_k127_4290829_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004059 267.0
SHD2_k127_4290829_3 endonuclease III K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000009766 244.0
SHD2_k127_4290829_4 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000009472 227.0
SHD2_k127_4290829_5 Fe-S metabolism associated domain K02426 - - 0.000000000000000000000000000000000000000000000000000000005875 201.0
SHD2_k127_4290829_6 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000000000000000000000000000000000000000006776 205.0
SHD2_k127_4290829_7 - - - - 0.000000000000000000000000000000000000000000001843 169.0
SHD2_k127_4290829_8 Transcriptional regulator - - - 0.00000000000000000000000000000000000000003198 160.0
SHD2_k127_4290829_9 - - - - 0.00000000000000000000000306 112.0
SHD2_k127_4292017_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000001509 238.0
SHD2_k127_4292017_1 ErfK ybiS ycfS ynhG family protein K19234 - - 0.000000000000000000000000000000000000000000000000000009523 196.0
SHD2_k127_4292017_2 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000004601 112.0
SHD2_k127_4292017_3 peptidyl-tyrosine sulfation - - - 0.00000007383 58.0
SHD2_k127_4297406_0 POT family K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 596.0
SHD2_k127_4297406_1 POT family K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 596.0
SHD2_k127_4297406_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 464.0
SHD2_k127_4297406_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006109 460.0
SHD2_k127_4297406_4 Glycosyl transferase family 2 K08301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009308 295.0
SHD2_k127_4297406_5 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002109 267.0
SHD2_k127_4297406_6 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000006965 198.0
SHD2_k127_4297406_7 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000001684 196.0
SHD2_k127_4297406_8 Glycine oxidase K03153 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19 0.0000000000000000000000000000000000000000000323 175.0
SHD2_k127_4297406_9 - - - - 0.000000006119 60.0
SHD2_k127_4317068_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 509.0
SHD2_k127_4317068_1 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 432.0
SHD2_k127_4317068_2 S4 RNA-binding domain K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 307.0
SHD2_k127_4317396_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0 1135.0
SHD2_k127_4317396_1 Peptidase dimerisation domain - - - 7.794e-207 654.0
SHD2_k127_4317396_2 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 597.0
SHD2_k127_4317396_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 589.0
SHD2_k127_4317396_4 Surface antigen K07277,K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 549.0
SHD2_k127_4317396_5 Domain of unknown function (DUF4173) - - - 0.00000000000000000000000000000000000636 154.0
SHD2_k127_4317396_6 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000118 116.0
SHD2_k127_4319396_0 Collagenase K08303 - - 0.0 1026.0
SHD2_k127_4319396_1 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004669 359.0
SHD2_k127_4319396_2 PFAM Aminotransferase, class IV K00824 - 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000001874 252.0
SHD2_k127_4319396_3 Acyclic terpene utilisation family protein AtuA - - - 0.0000000000000000000000000000000000000000000000000000000000000001772 222.0
SHD2_k127_4319396_4 - - - - 0.00000000000000000000000000000000000000000000000000002167 193.0
SHD2_k127_4319396_5 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000805 129.0
SHD2_k127_4319396_7 transferase activity, transferring glycosyl groups - - - 0.00001468 56.0
SHD2_k127_4319421_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 3.878e-286 897.0
SHD2_k127_4319421_1 ABC transporter transmembrane region K18889 - - 3.608e-229 724.0
SHD2_k127_4319421_10 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 411.0
SHD2_k127_4319421_11 Protein kinase domain K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 389.0
SHD2_k127_4319421_12 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 392.0
SHD2_k127_4319421_13 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 369.0
SHD2_k127_4319421_14 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 352.0
SHD2_k127_4319421_15 Peptidase family M20/M25/M40 K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008388 344.0
SHD2_k127_4319421_16 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 315.0
SHD2_k127_4319421_17 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002159 286.0
SHD2_k127_4319421_18 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000002475 256.0
SHD2_k127_4319421_19 Catalyzes the attachment of glycine to tRNA(Gly) K01880 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000358 243.0
SHD2_k127_4319421_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 601.0
SHD2_k127_4319421_21 - - - - 0.000000000000000000000000001378 114.0
SHD2_k127_4319421_22 - - - - 0.000000000000000006675 91.0
SHD2_k127_4319421_23 - - - - 0.0000000000000001772 88.0
SHD2_k127_4319421_24 PFAM response regulator receiver K02483,K07667 - - 0.00000000000001479 78.0
SHD2_k127_4319421_3 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 570.0
SHD2_k127_4319421_4 metalloendopeptidase activity K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 551.0
SHD2_k127_4319421_5 Major facilitator superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 488.0
SHD2_k127_4319421_6 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 481.0
SHD2_k127_4319421_7 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 460.0
SHD2_k127_4319421_8 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 414.0
SHD2_k127_4319421_9 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 408.0
SHD2_k127_4349339_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K00087 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 589.0
SHD2_k127_4349339_1 PFAM regulatory protein TetR - - - 0.000000000005249 72.0
SHD2_k127_4355419_0 Bacterial protein of unknown function (DUF885) - - - 1.594e-227 721.0
SHD2_k127_4355419_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 576.0
SHD2_k127_4355419_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 436.0
SHD2_k127_4355419_3 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 379.0
SHD2_k127_4355419_4 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 364.0
SHD2_k127_4355419_5 SURF1 family K14998 - - 0.0000000000000000000000000000000000000000000000000000000000000006046 226.0
SHD2_k127_4355419_7 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.000001099 59.0
SHD2_k127_4369123_0 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 382.0
SHD2_k127_4369123_1 4Fe-4S dicluster domain K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002554 284.0
SHD2_k127_4369123_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000165 115.0
SHD2_k127_4369123_3 Histidine kinase-like ATPase domain - - - 0.0000000000000000000000001043 113.0
SHD2_k127_4369123_4 STAS domain K04749,K06378 - - 0.0000000000000000001575 92.0
SHD2_k127_4369123_5 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000006388 61.0
SHD2_k127_4369558_0 Outer membrane protein beta-barrel family - - - 0.0 1025.0
SHD2_k127_4369558_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 2.414e-198 634.0
SHD2_k127_4369558_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 503.0
SHD2_k127_4369558_3 Pfam:SusD K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 470.0
SHD2_k127_4369558_4 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 466.0
SHD2_k127_4369558_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 404.0
SHD2_k127_4369558_6 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 327.0
SHD2_k127_4369558_7 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000004853 128.0
SHD2_k127_4369558_8 Alpha/beta hydrolase family - - - 0.0000000000000000000001256 99.0
SHD2_k127_4369558_9 FAD dependent oxidoreductase - - - 0.00000000005917 63.0
SHD2_k127_4374647_0 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 383.0
SHD2_k127_4374647_1 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 346.0
SHD2_k127_4374647_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000006505 232.0
SHD2_k127_4374647_3 Protein of unknown function (DUF418) K07148 - - 0.00001049 50.0
SHD2_k127_4375709_0 ABC transporter transmembrane region K11085 - - 5.403e-233 737.0
SHD2_k127_4375709_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000008617 195.0
SHD2_k127_4375709_2 PFAM LemA family protein K03744 - - 0.00000000000000005249 82.0
SHD2_k127_4381173_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 565.0
SHD2_k127_4381173_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 454.0
SHD2_k127_4381173_10 HIT domain K02503 - - 0.000000000000000000000000000000000000001707 151.0
SHD2_k127_4381173_2 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 452.0
SHD2_k127_4381173_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 444.0
SHD2_k127_4381173_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 347.0
SHD2_k127_4381173_5 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 343.0
SHD2_k127_4381173_6 Met-10+ like-protein K02687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 295.0
SHD2_k127_4381173_7 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000006331 232.0
SHD2_k127_4381173_8 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000000000000001941 223.0
SHD2_k127_4381173_9 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000000001749 210.0
SHD2_k127_4395718_0 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009609 584.0
SHD2_k127_4395718_1 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 379.0
SHD2_k127_4395718_10 - - - - 0.00000000000000001206 89.0
SHD2_k127_4395718_11 Outer membrane protein beta-barrel domain - - - 0.000000207 60.0
SHD2_k127_4395718_2 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 354.0
SHD2_k127_4395718_3 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 347.0
SHD2_k127_4395718_4 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 315.0
SHD2_k127_4395718_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 315.0
SHD2_k127_4395718_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 297.0
SHD2_k127_4395718_7 negative regulation of phosphate transmembrane transport K02039 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000242 262.0
SHD2_k127_4395718_9 - - - - 0.00000000000000000000000004088 110.0
SHD2_k127_4424703_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 509.0
SHD2_k127_4424703_1 Trypsin K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 487.0
SHD2_k127_4424703_2 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 440.0
SHD2_k127_4424703_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008947 301.0
SHD2_k127_4424703_4 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000006089 270.0
SHD2_k127_4424703_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07658 - - 0.00000000000000000000000000000000000000000000000000000000000000000004689 241.0
SHD2_k127_4424703_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000005379 239.0
SHD2_k127_4424703_7 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000005415 141.0
SHD2_k127_4424703_8 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000001145 140.0
SHD2_k127_4434942_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 343.0
SHD2_k127_4434942_1 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000001273 169.0
SHD2_k127_4448425_0 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 517.0
SHD2_k127_4448425_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000005529 252.0
SHD2_k127_4448425_2 - - - - 0.00000000000000000000000000000000000000000000000000000009499 211.0
SHD2_k127_4448425_3 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.0000000000000000000000000000000000000008838 149.0
SHD2_k127_4448425_4 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000002639 133.0
SHD2_k127_4448425_5 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 0.000006934 53.0
SHD2_k127_445756_0 lysine biosynthetic process via aminoadipic acid - - - 0.0 1105.0
SHD2_k127_445756_1 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006151 413.0
SHD2_k127_445756_2 cAMP biosynthetic process K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000001988 201.0
SHD2_k127_445756_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000619 180.0
SHD2_k127_445756_4 Polysaccharide lyase family 4, domain II - - - 0.00000000000000000000000000002551 129.0
SHD2_k127_445756_5 Chromate resistance exported protein - - - 0.0008703 43.0
SHD2_k127_4462931_0 Arginosuccinate synthase K01940 - 6.3.4.5 8.378e-215 672.0
SHD2_k127_4462931_1 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 1.613e-196 623.0
SHD2_k127_4462931_2 Regulates arginine biosynthesis genes K03402 - - 0.0000000000000000000000000000000000000000000000000006602 187.0
SHD2_k127_4462931_3 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000001228 119.0
SHD2_k127_4473059_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 1.061e-235 736.0
SHD2_k127_4473059_1 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 426.0
SHD2_k127_4473059_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 419.0
SHD2_k127_4473059_3 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 362.0
SHD2_k127_4473059_4 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004491 287.0
SHD2_k127_4473059_5 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000000000000000000000000000000000000000000517 229.0
SHD2_k127_4473059_6 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000001778 88.0
SHD2_k127_4473059_7 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000003662 60.0
SHD2_k127_4518057_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 596.0
SHD2_k127_4518057_1 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000805 384.0
SHD2_k127_4518057_10 - - - - 0.000000002629 63.0
SHD2_k127_4518057_12 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.00009787 45.0
SHD2_k127_4518057_2 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001258 280.0
SHD2_k127_4518057_3 Clp amino terminal domain, pathogenicity island component K03696 - - 0.000000000000000000000000000000000000000000000009698 175.0
SHD2_k127_4518057_4 - K01865 - 5.4.4.1 0.0000000000000000000000000000000000000000000001329 175.0
SHD2_k127_4518057_5 - - - - 0.000000000000000000000000000000000000000000001242 172.0
SHD2_k127_4518057_6 Membrane protein involved in cytochrome C biogenesis - - - 0.00000000000000000000000000000000000000002808 158.0
SHD2_k127_4518057_7 Uncharacterized protein conserved in bacteria (DUF2219) - - - 0.0000000000000000000000000000000001383 145.0
SHD2_k127_4518057_8 Protein of unknown function (DUF4242) - - - 0.0000000000000000003167 89.0
SHD2_k127_4518057_9 sequence-specific DNA binding K07729 - - 0.000000000000007458 81.0
SHD2_k127_4519863_0 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000003807 72.0
SHD2_k127_4519863_1 Universal stress protein family - - - 0.000005741 58.0
SHD2_k127_4573776_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 3.271e-255 791.0
SHD2_k127_4573776_1 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 473.0
SHD2_k127_4573776_2 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 439.0
SHD2_k127_4573776_3 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 335.0
SHD2_k127_4573776_4 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005056 291.0
SHD2_k127_4573776_5 proteins of the AP superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001161 271.0
SHD2_k127_4588272_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 477.0
SHD2_k127_4588272_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 328.0
SHD2_k127_4596536_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 7.924e-228 745.0
SHD2_k127_4596536_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009072 251.0
SHD2_k127_4596536_2 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000001136 213.0
SHD2_k127_4596536_3 Domain of unknown function (DUF4384) - - - 0.000004688 59.0
SHD2_k127_4621114_0 Sodium:solute symporter family - - - 3.747e-203 640.0
SHD2_k127_4621114_1 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 329.0
SHD2_k127_4625998_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 6.854e-259 810.0
SHD2_k127_4625998_1 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 424.0
SHD2_k127_4625998_2 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005121 308.0
SHD2_k127_4625998_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 302.0
SHD2_k127_4625998_4 PTS system sorbose-specific iic component K02795 - - 0.000000000000000000000000000000000000000000000000000000000003832 216.0
SHD2_k127_4625998_5 PTS system sorbose subfamily IIB component K19507 - - 0.000000000000000000000000000000000000000000000000000000000009735 211.0
SHD2_k127_4625998_6 PTS system fructose IIA component K02744 - - 0.0000000000000000000000000001387 120.0
SHD2_k127_4625998_7 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000000000001619 118.0
SHD2_k127_4637969_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 531.0
SHD2_k127_4637969_1 Cys/Met metabolism PLP-dependent enzyme K01761 - 4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 351.0
SHD2_k127_4637969_2 beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 309.0
SHD2_k127_4637969_3 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004332 279.0
SHD2_k127_4637969_4 Belongs to the aspartate glutamate racemases family K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000005116 199.0
SHD2_k127_4637969_5 DinB family - - - 0.000000000000000000000000000000000000000000000001409 179.0
SHD2_k127_4637969_6 Protein of unknown function (DUF4230) - - - 0.0000001055 62.0
SHD2_k127_4642967_0 peptidase K01415,K07386 - 3.4.24.71 2.506e-221 706.0
SHD2_k127_4642967_1 Carboxypeptidase regulatory-like domain - - - 4.539e-214 709.0
SHD2_k127_4642967_10 DNA-templated transcription, initiation K03088 - - 0.0000000000000005189 86.0
SHD2_k127_4642967_2 Fumarylacetoacetase N-terminal K01555 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 575.0
SHD2_k127_4642967_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 518.0
SHD2_k127_4642967_4 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 391.0
SHD2_k127_4642967_5 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000000000000000000000000000000000000000008403 215.0
SHD2_k127_4642967_6 ApaG domain K06195 - - 0.0000000000000000000000000000000000000000000000000001365 189.0
SHD2_k127_4642967_7 phosphatase activity K07025 - - 0.000000000000000000000000000000000000000000000000004903 188.0
SHD2_k127_4642967_8 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000001879 187.0
SHD2_k127_4642967_9 Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000002222 171.0
SHD2_k127_4651756_0 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 438.0
SHD2_k127_4651756_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000004451 135.0
SHD2_k127_4651756_2 - - - - 0.000000000000000000000000000002373 128.0
SHD2_k127_4651756_3 - - - - 0.00000000002599 66.0
SHD2_k127_4651756_4 CoA-transferase family III - - - 0.0000000001177 62.0
SHD2_k127_4656660_0 DeoC/LacD family aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 440.0
SHD2_k127_4656660_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004776 292.0
SHD2_k127_4656660_2 HAD-hyrolase-like K06019 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000001987 213.0
SHD2_k127_4664999_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 0.0 1028.0
SHD2_k127_4664999_1 Dipeptidyl peptidase IV (DPP IV) N-terminal region - - - 2.753e-269 849.0
SHD2_k127_4664999_2 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 550.0
SHD2_k127_4664999_3 Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 507.0
SHD2_k127_4664999_4 Major facilitator Superfamily K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 460.0
SHD2_k127_4664999_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 430.0
SHD2_k127_4664999_6 Mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000000000000000000000001312 202.0
SHD2_k127_4664999_7 Selenoprotein, putative - - - 0.00000000000005675 74.0
SHD2_k127_473026_0 Peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 509.0
SHD2_k127_473026_1 Semialdehyde dehydrogenase, NAD binding domain K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 349.0
SHD2_k127_4766233_0 Clp amino terminal domain, pathogenicity island component K03696 - - 0.0 1419.0
SHD2_k127_4804175_0 Sugar (and other) transporter - - - 3.964e-204 643.0
SHD2_k127_4804175_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 601.0
SHD2_k127_4804175_10 Penicillin amidase K01434 - 3.5.1.11 0.0000000006455 60.0
SHD2_k127_4804175_2 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005943 535.0
SHD2_k127_4804175_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000734 381.0
SHD2_k127_4804175_4 Beta-lactamase K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008967 316.0
SHD2_k127_4804175_5 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000006367 253.0
SHD2_k127_4804175_6 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000000001116 207.0
SHD2_k127_4804175_7 DUF218 domain - - - 0.000000000000000000000000000000000000006178 156.0
SHD2_k127_4819698_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 389.0
SHD2_k127_4819698_1 Nucleotidyl transferase K00978 - 2.7.7.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 349.0
SHD2_k127_4819698_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism - - - 0.00000000000000000000000000000000000000000000000009736 190.0
SHD2_k127_4819698_3 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000001011 179.0
SHD2_k127_4819698_4 PFAM NAD-dependent epimerase dehydratase K01709 - 4.2.1.45 0.00000000000000000000000000000000004222 138.0
SHD2_k127_4819698_5 Trm112p-like protein K09791 - - 0.0000000000000000000000167 102.0
SHD2_k127_4819698_6 PFAM Sodium calcium exchanger protein K07300 - - 0.000000000000002905 77.0
SHD2_k127_4871369_0 hydroxymethylglutaryl-CoA reductase K00021 - 1.1.1.34 5.334e-209 679.0
SHD2_k127_4871369_1 dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007085 512.0
SHD2_k127_4871369_10 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000003862 74.0
SHD2_k127_4871369_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 398.0
SHD2_k127_4871369_3 Protein of unknown function (DUF3419) - - - 0.00000000000000000000000000000000000000000000000000000000000000001408 240.0
SHD2_k127_4871369_4 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000000000000000000006336 194.0
SHD2_k127_4871369_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000002283 181.0
SHD2_k127_4871369_6 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000001239 184.0
SHD2_k127_4871369_7 PFAM AMP-dependent synthetase and ligase K22319 - 6.1.3.1 0.00000000000000000000000000000000000000000000008729 187.0
SHD2_k127_4871369_8 Belongs to the P-Pant transferase superfamily K06133 - - 0.0000000000000000000000000000001476 132.0
SHD2_k127_4871369_9 - - - - 0.00000000000000000000000000000103 122.0
SHD2_k127_4874463_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 1.223e-296 955.0
SHD2_k127_4874463_1 NlpC/P60 family - - - 0.000000000000000000000000000000000000000000000000000005057 199.0
SHD2_k127_4927774_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 523.0
SHD2_k127_4927774_1 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 311.0
SHD2_k127_4927774_2 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000006605 226.0
SHD2_k127_4927774_3 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000975 188.0
SHD2_k127_4934250_0 Carbamoyltransferase C-terminus K00612 - - 1.016e-282 880.0
SHD2_k127_4934250_1 Belongs to the DEAD box helicase family K05592,K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 9.544e-211 671.0
SHD2_k127_4934250_10 - - - - 0.000000000000000000000000000000000000004025 154.0
SHD2_k127_4934250_11 TonB dependent receptor K02014,K16087 - - 0.000000000000000000000000000000000002576 150.0
SHD2_k127_4934250_12 Domain of unknown function (DUF1330) - - - 0.000000000000000000000000000000006364 130.0
SHD2_k127_4934250_13 - - - - 0.00000000000000000000004062 107.0
SHD2_k127_4934250_14 - - - - 0.000000000000000008304 86.0
SHD2_k127_4934250_15 helix_turn_helix multiple antibiotic resistance protein K06075 - - 0.00000002362 63.0
SHD2_k127_4934250_2 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009456 434.0
SHD2_k127_4934250_3 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 347.0
SHD2_k127_4934250_4 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000002828 262.0
SHD2_k127_4934250_5 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000001073 224.0
SHD2_k127_4934250_6 histidine-tRNA ligase activity K01892,K02502 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000005783 220.0
SHD2_k127_4934250_7 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000000000000001424 197.0
SHD2_k127_4934250_8 Histidine kinase - - - 0.000000000000000000000000000000000000000001028 174.0
SHD2_k127_4934250_9 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000469 162.0
SHD2_k127_4938462_0 Insulinase (Peptidase family M16) K07263 - - 1.55e-261 826.0
SHD2_k127_4938462_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 429.0
SHD2_k127_4938462_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 332.0
SHD2_k127_4938462_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000005011 151.0
SHD2_k127_4938462_4 - - - - 0.00000000000000000000000001302 111.0
SHD2_k127_4964482_0 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 568.0
SHD2_k127_4964482_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 466.0
SHD2_k127_4964482_10 Domain of unknown function (DUF4412) - - - 0.000000000000000009045 95.0
SHD2_k127_4964482_11 - - - - 0.000000000000001092 81.0
SHD2_k127_4964482_12 - - - - 0.00001217 55.0
SHD2_k127_4964482_2 Integral membrane protein TerC family K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 374.0
SHD2_k127_4964482_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 306.0
SHD2_k127_4964482_4 Carboxylesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003171 291.0
SHD2_k127_4964482_5 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000007544 184.0
SHD2_k127_4964482_6 OsmC-like protein K07397 - - 0.000000000000000000000000000000000000000004646 158.0
SHD2_k127_4964482_7 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000000000000246 145.0
SHD2_k127_4964482_8 - - - - 0.000000000000000000000000000000002815 132.0
SHD2_k127_4964482_9 - - - - 0.0000000000000000000000165 103.0
SHD2_k127_499864_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002887 490.0
SHD2_k127_499864_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000003074 157.0
SHD2_k127_5067180_0 PFAM Protein kinase domain - - - 4.219e-212 694.0
SHD2_k127_5067180_1 Fatty acid desaturase K03921 - 1.14.19.11,1.14.19.2,1.14.19.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 499.0
SHD2_k127_5067180_11 PFAM PRC-barrel domain - - - 0.00000000000000003174 87.0
SHD2_k127_5067180_12 - - - - 0.000000000001037 72.0
SHD2_k127_5067180_13 DinB superfamily - - - 0.000000000001429 75.0
SHD2_k127_5067180_2 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 486.0
SHD2_k127_5067180_3 metal ion transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 486.0
SHD2_k127_5067180_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005991 289.0
SHD2_k127_5067180_5 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005033 269.0
SHD2_k127_5067180_6 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000009204 191.0
SHD2_k127_5067180_7 Acetyltransferase (GNAT) domain K02348 - - 0.0000000000000000000000000000000000000000000003546 171.0
SHD2_k127_5067180_8 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000682 156.0
SHD2_k127_5067180_9 Evidence 4 Homologs of previously reported genes of K09700 - - 0.0000000000000000000000000000000000002664 142.0
SHD2_k127_5086047_0 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 521.0
SHD2_k127_5086047_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 477.0
SHD2_k127_5086047_2 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 476.0
SHD2_k127_5086047_3 4Fe-4S single cluster domain K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 424.0
SHD2_k127_5086047_4 23S rRNA-intervening sequence protein - - - 0.000000000000001083 82.0
SHD2_k127_5105790_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 592.0
SHD2_k127_5105790_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006197 489.0
SHD2_k127_5105790_10 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000007144 72.0
SHD2_k127_5105790_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 474.0
SHD2_k127_5105790_3 Acyl transferase domain K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 385.0
SHD2_k127_5105790_4 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 386.0
SHD2_k127_5105790_5 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 327.0
SHD2_k127_5105790_6 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000002462 220.0
SHD2_k127_5105790_7 NDK K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000004 218.0
SHD2_k127_5105790_8 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000000000000000000000000000000001756 210.0
SHD2_k127_5105790_9 Ribosomal L32p protein family K02911 - - 0.00000000000000000000000001069 109.0
SHD2_k127_5120584_0 Beta-eliminating lyase K01668 - 4.1.99.2 9.327e-205 646.0
SHD2_k127_5120584_1 lyase activity K01667 - 4.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 334.0
SHD2_k127_5172741_0 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 367.0
SHD2_k127_5172741_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 363.0
SHD2_k127_5172741_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 323.0
SHD2_k127_5172741_3 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 293.0
SHD2_k127_5172741_4 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000001055 189.0
SHD2_k127_5172741_5 - - - - 0.0000000001112 64.0
SHD2_k127_5172741_6 PFAM Roadblock LC7 family protein K07131 GO:0001101,GO:0003674,GO:0005085,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0009719,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0019899,GO:0023051,GO:0023056,GO:0032006,GO:0032008,GO:0032947,GO:0042221,GO:0043200,GO:0044464,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051020,GO:0051716,GO:0065007,GO:0065009,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0098772,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 - 0.000001175 55.0
SHD2_k127_5172741_7 Roadblock/LC7 domain - - - 0.0005863 49.0
SHD2_k127_5200208_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 4.357e-203 636.0
SHD2_k127_5200208_1 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000383 142.0
SHD2_k127_5287323_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 454.0
SHD2_k127_5287323_1 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 423.0
SHD2_k127_5287323_2 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 367.0
SHD2_k127_5287323_3 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 385.0
SHD2_k127_5287323_4 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 297.0
SHD2_k127_5287323_5 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003844 236.0
SHD2_k127_5287323_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000001019 206.0
SHD2_k127_5287323_7 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.000000000000000000000000000000000005831 139.0
SHD2_k127_5287323_8 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000001369 85.0
SHD2_k127_5287323_9 Prokaryotic N-terminal methylation motif - - - 0.00000000000001169 82.0
SHD2_k127_5299000_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009287 450.0
SHD2_k127_5299000_1 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001292 243.0
SHD2_k127_5314082_0 - - - - 1.998e-198 650.0
SHD2_k127_5314082_1 WD-40 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009093 409.0
SHD2_k127_5314082_10 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000001183 134.0
SHD2_k127_5314082_11 MgtC family K07507 - - 0.0000000000000000000000000000005745 126.0
SHD2_k127_5314082_12 - - - - 0.00000000000000000000000004045 115.0
SHD2_k127_5314082_13 - - - - 0.0000000000009821 77.0
SHD2_k127_5314082_14 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.0000000174 56.0
SHD2_k127_5314082_15 translation initiation factor activity K06996 - - 0.000001948 51.0
SHD2_k127_5314082_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 374.0
SHD2_k127_5314082_3 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 332.0
SHD2_k127_5314082_4 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 308.0
SHD2_k127_5314082_5 Tryptophan-rich sensory protein K05770 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004651 255.0
SHD2_k127_5314082_6 WD40 repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000002009 261.0
SHD2_k127_5314082_7 catalytic domain of ctd-like phosphatases - - - 0.00000000000000000000000000000000000000000000008447 174.0
SHD2_k127_5314082_8 DNA mediated transformation K04096 - - 0.0000000000000000000000000000000002615 139.0
SHD2_k127_5314082_9 Protein of unknown function (DUF1254) - - - 0.000000000000000000000000000000002672 132.0
SHD2_k127_5322177_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000003132 178.0
SHD2_k127_5322177_1 DNA-binding transcription factor activity - - - 0.000000000000003465 87.0
SHD2_k127_5322714_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 522.0
SHD2_k127_5322714_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 485.0
SHD2_k127_5322714_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000000000000000000000000000003135 181.0
SHD2_k127_5322714_3 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000001011 140.0
SHD2_k127_5322714_4 ThiS family K03636 - - 0.000000000000001565 82.0
SHD2_k127_5335226_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1219.0
SHD2_k127_5335226_1 amine dehydrogenase activity - - - 6.054e-242 772.0
SHD2_k127_5335226_10 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008893 289.0
SHD2_k127_5335226_11 Fimbrial assembly protein (PilN) - - - 0.000000000000000000000000000000000000000000000000001409 192.0
SHD2_k127_5335226_12 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000006324 162.0
SHD2_k127_5335226_13 Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000002539 160.0
SHD2_k127_5335226_14 - - - - 0.000000000000000000000000000000000009501 142.0
SHD2_k127_5335226_15 - - - - 0.00000000000000000000000001735 122.0
SHD2_k127_5335226_17 Protein of unknown function (DUF494) K03747 - - 0.000000000000000001421 87.0
SHD2_k127_5335226_18 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.00000000000000005641 86.0
SHD2_k127_5335226_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.769e-225 709.0
SHD2_k127_5335226_3 AMIN domain K02666 - - 9.716e-215 687.0
SHD2_k127_5335226_4 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 1.294e-210 663.0
SHD2_k127_5335226_5 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 566.0
SHD2_k127_5335226_6 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 448.0
SHD2_k127_5335226_7 Phage integrase, N-terminal SAM-like domain K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 440.0
SHD2_k127_5335226_8 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 341.0
SHD2_k127_5335226_9 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 314.0
SHD2_k127_5356217_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 537.0
SHD2_k127_5356217_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 515.0
SHD2_k127_5356217_2 Cell cycle protein K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 458.0
SHD2_k127_5356217_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001226 283.0
SHD2_k127_5356488_0 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 382.0
SHD2_k127_5356488_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000008074 179.0
SHD2_k127_5356488_2 Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000009861 166.0
SHD2_k127_5356488_3 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) - - - 0.00000000000000000000000000000000485 142.0
SHD2_k127_5368173_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K02567 - - 2.498e-283 892.0
SHD2_k127_5368173_1 hydrogenase expression formation protein HypD K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 517.0
SHD2_k127_5368173_2 Small subunit K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 438.0
SHD2_k127_5368173_3 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 388.0
SHD2_k127_5368173_4 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 317.0
SHD2_k127_5368173_5 heat shock protein binding - - - 0.00000000000000000000000000002512 136.0
SHD2_k127_5368173_6 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000003421 130.0
SHD2_k127_5368173_7 HupF/HypC family K04653 - - 0.0000000000000000000000004098 109.0
SHD2_k127_5368173_8 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.0000000000000005554 92.0
SHD2_k127_5381185_0 Carbohydrate family 9 binding domain-like - - - 5.28e-262 834.0
SHD2_k127_5381185_1 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 411.0
SHD2_k127_5381185_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 312.0
SHD2_k127_5381185_3 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000001654 137.0
SHD2_k127_5392511_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 539.0
SHD2_k127_5392511_1 epimerase - - - 0.0000000000000000000000000000000000000000003275 161.0
SHD2_k127_5392511_2 Binding-protein-dependent transport system inner membrane component K02011 - - 0.000000000000000006347 86.0
SHD2_k127_5396710_0 PFAM transposase IS66 - - - 0.0000000000000000000000000000000000000000000000000000000003702 225.0
SHD2_k127_5396710_1 IS66 Orf2 like protein - - - 0.00000000000000000000000000003791 123.0
SHD2_k127_5396710_2 Transposase DDE domain - - - 0.00000000000000001093 85.0
SHD2_k127_5396710_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000001336 58.0
SHD2_k127_5397253_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 5.084e-239 746.0
SHD2_k127_5397253_1 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 565.0
SHD2_k127_5397253_2 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 387.0
SHD2_k127_5397253_3 PFAM amidohydrolase K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000002533 249.0
SHD2_k127_5397253_4 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000005714 120.0
SHD2_k127_5397253_5 PFAM nitrogen-fixing NifU domain protein - - - 0.0001543 52.0
SHD2_k127_5397398_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.041e-250 783.0
SHD2_k127_5397398_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 2.112e-218 685.0
SHD2_k127_5397398_2 Competence protein K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 590.0
SHD2_k127_5397398_3 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 565.0
SHD2_k127_5397398_4 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000005104 222.0
SHD2_k127_5397398_6 Regulatory protein, FmdB family - - - 0.000000000000002393 78.0
SHD2_k127_5397398_7 - - - - 0.0005415 48.0
SHD2_k127_5404323_0 Zinc carboxypeptidase - - - 5.154e-309 958.0
SHD2_k127_5404323_1 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000002349 222.0
SHD2_k127_5406916_0 Involved in the tonB-independent uptake of proteins - - - 0.0 1167.0
SHD2_k127_5414894_0 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008556 516.0
SHD2_k127_5414894_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 514.0
SHD2_k127_5414894_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 366.0
SHD2_k127_5414894_3 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000001421 183.0
SHD2_k127_5414894_4 - - - - 0.000000000006395 70.0
SHD2_k127_5414894_5 Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat - - - 0.00000004486 65.0
SHD2_k127_5414894_6 alginic acid biosynthetic process K10297 - - 0.0008175 45.0
SHD2_k127_5425136_0 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000000000000000002969 146.0
SHD2_k127_5425136_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000001618 140.0
SHD2_k127_5425136_2 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000004396 140.0
SHD2_k127_5425136_3 Multicopper oxidase K00368 - 1.7.2.1 0.000000000000000000000000000005664 124.0
SHD2_k127_5426479_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1397.0
SHD2_k127_5426479_1 Oligopeptide/dipeptide transporter, C-terminal region K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000478 534.0
SHD2_k127_5426479_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 544.0
SHD2_k127_5426479_3 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007981 505.0
SHD2_k127_5426479_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001147 282.0
SHD2_k127_5426479_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000259 214.0
SHD2_k127_5426479_6 Biotin/lipoate A/B protein ligase family K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000002204 209.0
SHD2_k127_5426479_7 POT family K03305 - - 0.00000000001512 67.0
SHD2_k127_5442833_0 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 590.0
SHD2_k127_5442833_1 Beta-eliminating lyase K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 307.0
SHD2_k127_5442833_2 Putative zinc-binding metallo-peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006115 299.0
SHD2_k127_5442833_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 293.0
SHD2_k127_5442833_4 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002481 246.0
SHD2_k127_5442833_5 - - - - 0.00001655 49.0
SHD2_k127_5443721_0 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 506.0
SHD2_k127_5443721_1 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 314.0
SHD2_k127_5450529_0 response to abiotic stimulus K03086,K06867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 518.0
SHD2_k127_5450529_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 481.0
SHD2_k127_5450529_10 DinB superfamily K07552 - - 0.0000000000000000000000000000002849 130.0
SHD2_k127_5450529_11 transferase activity, transferring acyl groups K03824,K15520 - 2.3.1.189 0.00000000000000000000000002344 115.0
SHD2_k127_5450529_2 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009092 466.0
SHD2_k127_5450529_3 Putative glucoamylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004996 448.0
SHD2_k127_5450529_4 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 427.0
SHD2_k127_5450529_5 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 299.0
SHD2_k127_5450529_6 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002396 250.0
SHD2_k127_5450529_7 dihydrofolate reductase activity K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000001734 229.0
SHD2_k127_5450529_8 DinB family - - - 0.00000000000000000000000000000000000000000006464 166.0
SHD2_k127_5450529_9 DinB superfamily - - - 0.00000000000000000000000000000000000001236 150.0
SHD2_k127_5473184_0 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 505.0
SHD2_k127_5473184_1 PFAM 4Fe-4S K00184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 406.0
SHD2_k127_5473184_2 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001991 286.0
SHD2_k127_5473184_3 - - - - 0.00000000000000000000000000003707 123.0
SHD2_k127_5479227_0 Branched-chain amino acid transport system / permease component K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 501.0
SHD2_k127_5479227_1 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 395.0
SHD2_k127_5479227_2 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 307.0
SHD2_k127_5479227_3 Sugar (and other) transporter - - - 0.0000000000000000003111 88.0
SHD2_k127_5485947_0 Transferase activity, transferring acyl groups other than amino-acyl groups. It is involved in the biological process described with metabolic process K07508,K17972 GO:0001666,GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006066,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006839,GO:0006915,GO:0006950,GO:0006996,GO:0007005,GO:0007006,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008219,GO:0008610,GO:0008637,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009628,GO:0009966,GO:0009968,GO:0009987,GO:0010639,GO:0010646,GO:0010648,GO:0010821,GO:0010823,GO:0010941,GO:0012501,GO:0016042,GO:0016043,GO:0016054,GO:0016125,GO:0016126,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0023051,GO:0023057,GO:0030258,GO:0031974,GO:0032787,GO:0032879,GO:0033043,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0035795,GO:0036293,GO:0036294,GO:0042221,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046165,GO:0046395,GO:0046483,GO:0046902,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051179,GO:0051186,GO:0051234,GO:0051716,GO:0055086,GO:0055114,GO:0060548,GO:0061024,GO:0065007,GO:0065008,GO:0070013,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071840,GO:0072329,GO:0072521,GO:0090559,GO:1901028,GO:1901029,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902108,GO:1902109,GO:1902652,GO:1902653,GO:1905709,GO:2001233,GO:2001234 2.3.1.16,2.3.1.254 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 398.0
SHD2_k127_5485947_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000001666 244.0
SHD2_k127_5485947_2 - - - - 0.000000000000000000000000000000002063 139.0
SHD2_k127_5485947_3 - - - - 0.00000000001078 66.0
SHD2_k127_5494869_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0 1148.0
SHD2_k127_5494869_1 NAD synthase K01916 - 6.3.1.5 4.055e-251 790.0
SHD2_k127_5494869_2 Yip1 domain - - - 0.000000000000000000000000000000000000000000000002878 178.0
SHD2_k127_5494869_3 Transglycosylase K21464 - 2.4.1.129,3.4.16.4 0.000001689 53.0
SHD2_k127_5508059_0 Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 600.0
SHD2_k127_5508059_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 535.0
SHD2_k127_5508059_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008936 529.0
SHD2_k127_5508059_3 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 351.0
SHD2_k127_5508059_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 312.0
SHD2_k127_5508059_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009854 274.0
SHD2_k127_5508059_6 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000000000000000002114 226.0
SHD2_k127_5508059_7 PD-(D/E)XK nuclease superfamily - - - 0.000000000000000000000000149 110.0
SHD2_k127_5508059_8 - - - - 0.0000000000000001524 84.0
SHD2_k127_5508059_9 PglZ domain - - - 0.0000001251 53.0
SHD2_k127_5514222_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1303.0
SHD2_k127_5514222_1 Bacterial protein of unknown function (DUF885) - - - 5.205e-250 790.0
SHD2_k127_5514222_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 443.0
SHD2_k127_5514222_3 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 384.0
SHD2_k127_5514222_4 Conserved hypothetical protein 95 K00564 - 2.1.1.172 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 305.0
SHD2_k127_5514222_5 Belongs to the pseudouridine synthase RsuA family K06183 - 5.4.99.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 293.0
SHD2_k127_5514222_6 endonuclease activity - - - 0.0000000000000000000000000000000000000000000000287 177.0
SHD2_k127_5514222_7 Rhomboid family - - - 0.0000000000000000000000000000000000000002919 151.0
SHD2_k127_5514222_8 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000000007038 126.0
SHD2_k127_5514222_9 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000001377 128.0
SHD2_k127_5521982_0 4 iron, 4 sulfur cluster binding K03737 - 1.2.7.1 0.0 1119.0
SHD2_k127_5521982_1 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 434.0
SHD2_k127_5521982_2 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 330.0
SHD2_k127_5521982_3 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000002036 233.0
SHD2_k127_5521982_4 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000000000000002488 218.0
SHD2_k127_5521982_5 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000001319 190.0
SHD2_k127_5521982_6 Part of a membrane complex involved in electron transport - - - 0.0000000000000000000000000000000004865 140.0
SHD2_k127_5521982_8 lyase activity K01667 - 4.1.99.1 0.0000000000000000003432 89.0
SHD2_k127_5535484_0 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006202 581.0
SHD2_k127_5535484_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689 385.0
SHD2_k127_5542301_0 PFAM Amidase - - - 6.699e-198 634.0
SHD2_k127_5542301_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 494.0
SHD2_k127_5542301_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000001851 215.0
SHD2_k127_5555421_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1389.0
SHD2_k127_5555421_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008926 510.0
SHD2_k127_5555421_2 Peptidase family M50 K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 403.0
SHD2_k127_5555421_3 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 303.0
SHD2_k127_5555421_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001563 283.0
SHD2_k127_5559739_0 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000628 495.0
SHD2_k127_5559739_1 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000002529 184.0
SHD2_k127_5559739_2 AntiSigma factor - - - 0.000000000000000000000000000000000000001262 158.0
SHD2_k127_5559739_3 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000001615 142.0
SHD2_k127_5559739_4 Ammonium Transporter K03320 - - 0.00000000000000000004554 92.0
SHD2_k127_5559739_5 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.000000008318 59.0
SHD2_k127_5561959_0 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002549 248.0
SHD2_k127_5561959_1 COG0346 Lactoylglutathione lyase and related lyases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008595 238.0
SHD2_k127_5561959_2 lactoylglutathione lyase activity - - - 0.0000000000000000000000000004383 117.0
SHD2_k127_5561959_3 lactoylglutathione lyase activity - - - 0.000000000000000000000008063 111.0
SHD2_k127_5561959_4 Protein of unknown function (DUF4256) - - - 0.00000000000000000003784 95.0
SHD2_k127_5561959_5 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.000000004019 64.0
SHD2_k127_5561959_6 Glyoxalase-like domain - - - 0.0008481 45.0
SHD2_k127_5563928_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005467 578.0
SHD2_k127_5563928_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 542.0
SHD2_k127_5563928_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000002684 214.0
SHD2_k127_5563928_3 Cell division protein FtsQ K03589 - - 0.000000000000000000000000000000000000000000003346 175.0
SHD2_k127_5563928_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000007459 69.0
SHD2_k127_5588605_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1511.0
SHD2_k127_5588605_1 Serine dehydratase beta chain K01752 - 4.3.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 293.0
SHD2_k127_5591697_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.563e-201 636.0
SHD2_k127_5591697_1 Pyridine nucleotide-disulphide oxidoreductase K21567 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 511.0
SHD2_k127_5591697_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 490.0
SHD2_k127_5602215_0 Sugar (and other) transporter K07058 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 1.032e-237 752.0
SHD2_k127_5602215_1 von Willebrand factor (vWF) type A domain - - - 7.847e-228 710.0
SHD2_k127_5602215_10 Copper resistance protein CopC K14166 - - 0.000000000000000006843 97.0
SHD2_k127_5602215_2 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 1.093e-216 683.0
SHD2_k127_5602215_3 Aminotransferase class-V - - - 6.12e-197 621.0
SHD2_k127_5602215_4 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006074 581.0
SHD2_k127_5602215_5 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005778 471.0
SHD2_k127_5602215_6 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 381.0
SHD2_k127_5602215_7 EVE domain - - - 0.0000000000000000000000000000000000000000000000000000000005157 205.0
SHD2_k127_5602215_8 Metal binding domain of Ada K00567,K10778 - 2.1.1.63 0.00000000000000000000000000000000000002079 151.0
SHD2_k127_5602215_9 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000001367 97.0
SHD2_k127_5613691_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 372.0
SHD2_k127_5613691_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001391 290.0
SHD2_k127_5613691_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000005096 202.0
SHD2_k127_5613691_3 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000008544 192.0
SHD2_k127_5613691_4 glycosyl transferase family 2 K20444 - - 0.000000000000000000000001321 114.0
SHD2_k127_5614469_0 Domain of unknown function (DUF5117) - - - 0.0 1060.0
SHD2_k127_5614469_1 TonB-dependent receptor K02014 - - 7.756e-254 811.0
SHD2_k127_5614469_11 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00001789 57.0
SHD2_k127_5614469_2 Peptidase family M13 K07386 - - 1.726e-247 781.0
SHD2_k127_5614469_3 PFAM ATP dependent DNA ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 455.0
SHD2_k127_5614469_4 PFAM Phenazine biosynthesis PhzC PhzF protein K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 331.0
SHD2_k127_5614469_5 ADP-glyceromanno-heptose 6-epimerase activity K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000008756 207.0
SHD2_k127_5614469_6 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000139 176.0
SHD2_k127_5614469_7 translation initiation inhibitor, yjgF family K04782 - 4.2.99.21 0.0000000000000000000000000000000000000000000003112 171.0
SHD2_k127_5614469_8 Cold shock protein domain K03704 - - 0.000000000000000000000000000000001096 134.0
SHD2_k127_5614469_9 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000122 121.0
SHD2_k127_5638115_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 3.258e-256 793.0
SHD2_k127_5638115_1 - - - - 0.0000000000000000000000000000000000988 135.0
SHD2_k127_5638115_2 - - - - 0.00000000000000000000000002561 114.0
SHD2_k127_5638115_3 Glycosyl transferases group 1 - - - 0.00000000000000000005984 95.0
SHD2_k127_5639041_0 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 491.0
SHD2_k127_5639041_1 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004935 392.0
SHD2_k127_5639041_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 323.0
SHD2_k127_5639041_3 4Fe-4S single cluster domain K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 316.0
SHD2_k127_5685314_0 Protein export membrane protein - - - 4.514e-246 768.0
SHD2_k127_5685314_1 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 437.0
SHD2_k127_5685314_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 391.0
SHD2_k127_5685314_3 TonB-dependent Receptor Plug K02014 - - 0.000000000000000000000000000000000000000000000000000000009125 215.0
SHD2_k127_5685314_4 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000003215 188.0
SHD2_k127_5685314_5 OsmC-like protein K06889,K07397 - - 0.000000000000000000000000000000000000000004646 158.0
SHD2_k127_5685314_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000009957 124.0
SHD2_k127_5685314_7 Protein of unknown function (DUF2892) - - - 0.000000000000000000000004297 104.0
SHD2_k127_5685314_8 - - - - 0.000000000000000247 85.0
SHD2_k127_5700690_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 532.0
SHD2_k127_5700690_1 ABC transporter K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001978 284.0
SHD2_k127_5700690_2 - - - - 0.0000000000000000000000000000000000000000001934 167.0
SHD2_k127_5700690_3 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000001119 158.0
SHD2_k127_5700690_4 - - - - 0.0000000000000000000005467 99.0
SHD2_k127_5700690_5 Part of the ABC transporter FtsEX involved in K09811 - - 0.0000001244 54.0
SHD2_k127_5702449_0 Surface antigen K07277 - - 1.643e-279 880.0
SHD2_k127_5702449_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 361.0
SHD2_k127_5702449_2 Outer membrane protein (OmpH-like) K06142 - - 0.0000000000000000000000000000002498 132.0
SHD2_k127_5705545_0 Bacterial regulatory protein, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 353.0
SHD2_k127_5705545_1 peroxidase activity K00435 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005034 251.0
SHD2_k127_5705545_2 serine-type peptidase activity K03641 - - 0.0000000000000000000000000000000000000000000002273 189.0
SHD2_k127_5705545_3 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000001878 137.0
SHD2_k127_5705545_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000008948 149.0
SHD2_k127_5705545_5 Major facilitator Superfamily - - - 0.0002962 43.0
SHD2_k127_5727820_0 TonB-linked outer membrane protein, SusC RagA family - - - 0.0 1502.0
SHD2_k127_5727820_1 Starch-binding associating with outer membrane - - - 1.218e-251 785.0
SHD2_k127_5727820_10 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.00001158 48.0
SHD2_k127_5727820_2 PFAM Bile acid sodium symporter K03325 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015297,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 535.0
SHD2_k127_5727820_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 415.0
SHD2_k127_5727820_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 410.0
SHD2_k127_5727820_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005504 334.0
SHD2_k127_5727820_6 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 340.0
SHD2_k127_5727820_7 AcrB/AcrD/AcrF family K07787,K15726 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008881 282.0
SHD2_k127_5727820_8 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001166 281.0
SHD2_k127_5727820_9 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000001638 182.0
SHD2_k127_5730772_0 peptidase K01415,K07386 - 3.4.24.71 5.233e-210 675.0
SHD2_k127_5730772_1 aminopeptidase N - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 562.0
SHD2_k127_5730772_2 FtsZ-dependent cytokinesis K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000002478 183.0
SHD2_k127_5730772_3 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000000000000000000000005958 187.0
SHD2_k127_5730772_4 DinB superfamily - - - 0.000000000000000000000000000001402 126.0
SHD2_k127_5730772_5 Bacterial protein of unknown function (DUF885) - - - 0.000000000000007456 88.0
SHD2_k127_5730772_6 Protein of unknown function (DUF4235) - - - 0.000000000005994 69.0
SHD2_k127_5730772_7 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.0000000007689 67.0
SHD2_k127_5730772_8 Protein of unknown function, DUF - - - 0.000004367 48.0
SHD2_k127_5734045_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 3.152e-234 734.0
SHD2_k127_5734045_1 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003526 535.0
SHD2_k127_5734045_2 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 297.0
SHD2_k127_5734045_3 - - - - 0.00000000000000000000000000000000000000000000000001053 191.0
SHD2_k127_5734045_4 UvrB/uvrC motif K19411 - - 0.00000000000000000008614 91.0
SHD2_k127_5734045_5 Diguanylate cyclase, GGDEF domain - - - 0.000000000001598 69.0
SHD2_k127_5734045_6 function. Source PGD - - - 0.000000002702 59.0
SHD2_k127_5739720_0 Transport of potassium into the cell K03549 - - 3.481e-251 790.0
SHD2_k127_5739720_1 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002399 253.0
SHD2_k127_5739720_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000001312 164.0
SHD2_k127_5739720_3 S4 RNA-binding domain K04762 - - 0.00000000000000000000000000000000003952 138.0
SHD2_k127_5739720_4 PDZ domain (Also known as DHR or GLGF) - - - 0.000001126 57.0
SHD2_k127_5751256_0 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 316.0
SHD2_k127_5751256_1 Belongs to the CDS family - - - 0.000000000000000000000000000000000000000000000000000006336 194.0
SHD2_k127_5751256_2 AMP binding - - - 0.00000003584 60.0
SHD2_k127_5756456_0 lysine biosynthetic process via aminoadipic acid - - - 9.731e-243 778.0
SHD2_k127_5756456_1 MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 547.0
SHD2_k127_5756456_2 OsmC-like protein K09136 - - 0.00000000000000002977 87.0
SHD2_k127_5771478_0 Phosphoesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 306.0
SHD2_k127_5771478_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001983 235.0
SHD2_k127_5771478_2 Acetoacetate metabolism regulatory protein atoC K02481 - - 0.000003529 51.0
SHD2_k127_5793178_0 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 299.0
SHD2_k127_5793178_1 Domain of unknown function (DUF4974) K07165 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001888 269.0
SHD2_k127_5809966_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 521.0
SHD2_k127_5809966_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000001169 94.0
SHD2_k127_5810733_0 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 431.0
SHD2_k127_5810733_1 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000002184 234.0
SHD2_k127_5828030_0 xanthine dehydrogenase activity - - - 0.0 1145.0
SHD2_k127_5828030_1 XdhC and CoxI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 418.0
SHD2_k127_5828030_2 2 iron, 2 sulfur cluster binding K03518,K07302,K13483 - 1.2.5.3,1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000005879 245.0
SHD2_k127_5828030_3 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000001581 231.0
SHD2_k127_5844924_0 succinyl-diaminopimelate desuccinylase activity K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007707 524.0
SHD2_k127_5844924_1 photoreceptor activity K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 381.0
SHD2_k127_5844924_2 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000002669 235.0
SHD2_k127_5844924_3 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000003331 185.0
SHD2_k127_5844924_4 Predicted membrane protein (DUF2127) - - - 0.00000000000000000000000000000002955 132.0
SHD2_k127_5844924_5 - - - - 0.0000000000000005238 85.0
SHD2_k127_5844924_6 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K07077 - - 0.00000001108 57.0
SHD2_k127_5844924_7 Oxidoreductase family, NAD-binding Rossmann fold K00118,K13020 - 1.1.1.335,1.1.99.28 0.00000006065 59.0
SHD2_k127_588175_0 Domain of unknown function (DUF2172) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 576.0
SHD2_k127_588175_1 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009934 308.0
SHD2_k127_588175_2 aminoglycoside 3-N-acetyltransferase activity K00662 - 2.3.1.81 0.00000000000000000000000000008251 126.0
SHD2_k127_5898214_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006834 248.0
SHD2_k127_5898214_1 - - - - 0.0000000000000000000000000000000000000000724 159.0
SHD2_k127_5898214_2 Ricin-type beta-trefoil - - - 0.000008579 58.0
SHD2_k127_5939768_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 9.977e-286 882.0
SHD2_k127_5939768_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 4.927e-233 730.0
SHD2_k127_5939768_2 YjbR - - - 0.000000000000000000000000000000000000000000000002649 176.0
SHD2_k127_5939768_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000005937 185.0
SHD2_k127_5939768_4 Biotin-requiring enzyme - - - 0.0000000000000000000000126 102.0
SHD2_k127_594250_0 Zinc carboxypeptidase K14054 - - 4.124e-310 968.0
SHD2_k127_594250_1 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 360.0
SHD2_k127_594250_2 Domain of unknown function (DUF4403) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 347.0
SHD2_k127_594250_3 LemA family K03744 - - 0.0000000000000000000001408 105.0
SHD2_k127_5953331_0 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 1.056e-215 676.0
SHD2_k127_5953331_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 437.0
SHD2_k127_5953331_2 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 415.0
SHD2_k127_5953331_3 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 347.0
SHD2_k127_5996431_0 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000164 138.0
SHD2_k127_5996431_1 O-antigen polysaccharide polymerase Wzy - - - 0.000000000000000000000000000145 131.0
SHD2_k127_5996431_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000009269 115.0
SHD2_k127_5996431_3 Glycosyl transferase, family 2 K07011 - - 0.000000000000000000132 100.0
SHD2_k127_6099417_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 514.0
SHD2_k127_6099417_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 480.0
SHD2_k127_6099417_2 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 471.0
SHD2_k127_6099417_3 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 430.0
SHD2_k127_6099417_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 352.0
SHD2_k127_6099417_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000001001 230.0
SHD2_k127_6099417_6 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000002184 223.0
SHD2_k127_6099417_7 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000005978 178.0
SHD2_k127_6099417_8 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000001297 77.0
SHD2_k127_6145359_0 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 502.0
SHD2_k127_6145359_1 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000005787 106.0
SHD2_k127_617297_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 5.074e-224 700.0
SHD2_k127_617297_1 Glycosyl transferase 4-like domain K08256,K12995 - 2.4.1.345,2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000004362 255.0
SHD2_k127_6250958_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 478.0
SHD2_k127_6250958_1 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 478.0
SHD2_k127_6250958_2 PFAM Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.0000000000000000000000000000000000000000000002252 173.0
SHD2_k127_6250958_3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000002483 76.0
SHD2_k127_6312124_0 Amidohydrolase family - - - 5.236e-232 732.0
SHD2_k127_6312124_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 9.979e-195 614.0
SHD2_k127_6312124_10 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000003349 198.0
SHD2_k127_6312124_11 - - - - 0.000000000000000000000000000000000000000000000000000001415 199.0
SHD2_k127_6312124_12 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000000000000000000000000006904 196.0
SHD2_k127_6312124_13 family 18 - - - 0.0000001455 63.0
SHD2_k127_6312124_14 - - - - 0.0000004291 56.0
SHD2_k127_6312124_2 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 497.0
SHD2_k127_6312124_3 FMN-dependent dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007771 448.0
SHD2_k127_6312124_4 Glucose inhibited division protein A K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 445.0
SHD2_k127_6312124_5 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003894 400.0
SHD2_k127_6312124_6 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006036 341.0
SHD2_k127_6312124_7 Major intrinsic protein K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 287.0
SHD2_k127_6312124_8 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007832 250.0
SHD2_k127_6312124_9 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000006475 213.0
SHD2_k127_6350312_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 459.0
SHD2_k127_6350312_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 318.0
SHD2_k127_6350312_2 protein methyltransferase activity K02687 - - 0.000000000000000000000000000000000000000000000004843 190.0
SHD2_k127_6350312_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000001564 153.0
SHD2_k127_6350312_4 Cytidylyltransferase K07257 - - 0.000000000000000005537 86.0
SHD2_k127_6366696_0 Sortilin, neurotensin receptor 3, - - - 0.0 1276.0
SHD2_k127_6366696_1 Peptidase family M20/M25/M40 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 459.0
SHD2_k127_6366696_2 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 387.0
SHD2_k127_6366696_3 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007478 254.0
SHD2_k127_6366696_4 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000003297 259.0
SHD2_k127_6366696_5 PFAM DsrE DsrF-like family K09004 - - 0.000000000000000000000000000000006046 139.0
SHD2_k127_6366696_6 protein homotetramerization - GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662 - 0.00000000000000000000000000008959 126.0
SHD2_k127_6366696_7 - - - - 0.0000000008236 63.0
SHD2_k127_6366696_8 CarboxypepD_reg-like domain - - - 0.00000007594 61.0
SHD2_k127_6366696_9 - - - - 0.000001777 56.0
SHD2_k127_6374321_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 323.0
SHD2_k127_6380589_0 PFAM amine oxidase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 3.611e-223 700.0
SHD2_k127_6380589_1 Tetratricopeptide repeat K08884,K12132 - 2.7.11.1 1.646e-221 709.0
SHD2_k127_6380589_2 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009739 345.0
SHD2_k127_6380589_3 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000009078 217.0
SHD2_k127_6380589_4 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000000000004941 193.0
SHD2_k127_6380589_5 - - - - 0.000000000000000000000000000000002465 131.0
SHD2_k127_6381795_0 Dehydrogenase - - - 0.0 1003.0
SHD2_k127_6381795_1 Sortilin, neurotensin receptor 3, - - - 5.408e-297 945.0
SHD2_k127_6381795_10 PFAM DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001268 274.0
SHD2_k127_6381795_11 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000004599 183.0
SHD2_k127_6381795_12 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.000000000000000000000000000000000000000000000002097 179.0
SHD2_k127_6381795_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000002618 158.0
SHD2_k127_6381795_14 - - - - 0.00000000000000000000000000000000000000003363 160.0
SHD2_k127_6381795_15 - - - - 0.00000000000000000000000000000000000002654 149.0
SHD2_k127_6381795_16 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000005971 154.0
SHD2_k127_6381795_17 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000002661 135.0
SHD2_k127_6381795_18 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000001312 134.0
SHD2_k127_6381795_19 ketosteroid isomerase - - - 0.00000000000000000000000000003205 129.0
SHD2_k127_6381795_2 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 3.845e-245 766.0
SHD2_k127_6381795_21 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000000001178 109.0
SHD2_k127_6381795_22 WHG domain - - - 0.000000000000000000008923 99.0
SHD2_k127_6381795_23 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000002062 87.0
SHD2_k127_6381795_3 Domain of unknown function (DUF5117) - - - 5.311e-221 702.0
SHD2_k127_6381795_4 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 573.0
SHD2_k127_6381795_5 Aldo Keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006475 398.0
SHD2_k127_6381795_6 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 381.0
SHD2_k127_6381795_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009789 353.0
SHD2_k127_6381795_8 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 309.0
SHD2_k127_6381795_9 Cysteine-rich motif following a subset of SET domains K07117 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001134 270.0
SHD2_k127_6381831_0 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 552.0
SHD2_k127_6381831_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 495.0
SHD2_k127_6381831_2 Methyltransferase small domain K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008954 302.0
SHD2_k127_6381831_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000005332 224.0
SHD2_k127_6381831_4 Control of competence regulator ComK, YlbF/YmcA - - - 0.00000000000000000000000000000000000000004654 155.0
SHD2_k127_6381831_5 Binds the 23S rRNA K02909 - - 0.00000000000000000000001309 101.0
SHD2_k127_6381831_6 Domain of unknown function (DUF2520) - - - 0.00000000000005151 81.0
SHD2_k127_6383280_0 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006704 391.0
SHD2_k127_6383280_1 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 329.0
SHD2_k127_6383280_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 328.0
SHD2_k127_6383280_3 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000001794 231.0
SHD2_k127_6383280_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000103 128.0
SHD2_k127_6383280_5 - - - - 0.00000001825 62.0
SHD2_k127_6397643_0 ABC transporter transmembrane region K11085 - - 5.735e-229 724.0
SHD2_k127_6397643_1 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 424.0
SHD2_k127_6397643_2 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 377.0
SHD2_k127_6397643_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006391 276.0
SHD2_k127_6397643_4 transferase activity, transferring glycosyl groups K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000001458 217.0
SHD2_k127_6397643_5 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000001405 195.0
SHD2_k127_6397643_6 Glycosyl transferases group 1 K13668 - 2.4.1.346 0.00000000000000000000000000000000000000634 161.0
SHD2_k127_6397643_7 DUF based on E. rectale Gene description (DUF3880) K06320 - - 0.000000000000009786 85.0
SHD2_k127_6397643_8 PglZ domain - - - 0.0000000000003569 68.0
SHD2_k127_6410414_0 metallocarboxypeptidase activity K14054 - - 0.0 1017.0
SHD2_k127_6410414_1 (ABC) transporter K06147,K06148 - - 7.224e-210 670.0
SHD2_k127_6410414_10 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000002541 141.0
SHD2_k127_6410414_11 lytic transglycosylase activity - - - 0.000000000000000001789 96.0
SHD2_k127_6410414_12 TadE-like protein - - - 0.000000000006227 76.0
SHD2_k127_6410414_13 TadE-like protein - - - 0.00000000003476 69.0
SHD2_k127_6410414_14 Type IV leader peptidase family - - - 0.000000005472 61.0
SHD2_k127_6410414_2 Type ii secretion system protein e K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 584.0
SHD2_k127_6410414_3 Pilus formation protein N terminal region K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 345.0
SHD2_k127_6410414_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 325.0
SHD2_k127_6410414_5 Flp pilus assembly protein CpaB K02279 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004717 265.0
SHD2_k127_6410414_6 Type ii secretion system K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001375 261.0
SHD2_k127_6410414_7 type II secretion system K12511 - - 0.00000000000000000000000000000000000000001767 164.0
SHD2_k127_6410414_8 Response regulator, receiver K02282 - - 0.00000000000000000000000000000000000002392 158.0
SHD2_k127_6410414_9 - - - - 0.0000000000000000000000000000000001314 143.0
SHD2_k127_6410838_0 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 429.0
SHD2_k127_6410838_1 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 348.0
SHD2_k127_6410838_2 Peptidase dimerisation domain K13049 - - 0.00000000000000000000000000000000000000000000000000000000000000001683 229.0
SHD2_k127_6433654_0 Sortilin, neurotensin receptor 3, - - - 0.0 1349.0
SHD2_k127_6433654_1 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000007763 216.0
SHD2_k127_6433654_2 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000000000000000000002902 212.0
SHD2_k127_6440323_0 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 594.0
SHD2_k127_6440323_1 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 593.0
SHD2_k127_6440323_2 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 531.0
SHD2_k127_6440323_3 - - - - 0.0000000000000000000000000000000000000000000000001362 183.0
SHD2_k127_6453848_0 WD40-like Beta Propeller Repeat - - - 2.88e-234 754.0
SHD2_k127_6462743_0 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009408 366.0
SHD2_k127_6462743_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000003136 288.0
SHD2_k127_6462743_2 Lipopolysaccharide-assembly - - - 0.00000000000000000000000000000000000000000000000000002746 194.0
SHD2_k127_6462743_3 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000001022 161.0
SHD2_k127_6462743_4 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.00000000000000000000000000000004829 139.0
SHD2_k127_6462743_5 - - - - 0.000000000000000000003543 102.0
SHD2_k127_6464989_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.568e-199 627.0
SHD2_k127_6464989_1 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 602.0
SHD2_k127_6464989_10 Histidine biosynthesis protein K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 297.0
SHD2_k127_6464989_11 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000001535 264.0
SHD2_k127_6464989_12 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003716 262.0
SHD2_k127_6464989_13 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000001411 246.0
SHD2_k127_6464989_14 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.00000000000000000000000000000000000000000000000000000000000000000000006578 243.0
SHD2_k127_6464989_15 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.000000000000000000000000000000000000000000000000000000000000000000761 233.0
SHD2_k127_6464989_16 - - - - 0.0000000000000000000000000000000000000000000008447 169.0
SHD2_k127_6464989_17 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000008341 136.0
SHD2_k127_6464989_18 Cell wall formation K00075 - 1.3.1.98 0.0005346 44.0
SHD2_k127_6464989_2 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007434 476.0
SHD2_k127_6464989_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 - 1.1.1.23,1.1.1.308 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 474.0
SHD2_k127_6464989_4 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 387.0
SHD2_k127_6464989_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 369.0
SHD2_k127_6464989_6 protein tyrosine kinase activity K16692 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 357.0
SHD2_k127_6464989_7 Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 335.0
SHD2_k127_6464989_8 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 299.0
SHD2_k127_6464989_9 Inositol monophosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 302.0
SHD2_k127_6471838_0 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004259 419.0
SHD2_k127_6471838_1 Domain of unknown function (DUF5118) - - - 0.0000000000000000000000000000000000002653 148.0
SHD2_k127_6497122_0 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 554.0
SHD2_k127_6497122_1 Esterase PHB depolymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009322 282.0
SHD2_k127_6497122_2 - - - - 0.0000000000000000000000000000000000000000000000000000001116 200.0
SHD2_k127_6497122_3 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000003016 170.0
SHD2_k127_6497122_4 N-terminal half of MaoC dehydratase K17865 - 4.2.1.55 0.000000000000000000000000000000000000000008159 158.0
SHD2_k127_6497122_5 Sodium:solute symporter family K14392 - - 0.0000000000000000000000000000005428 123.0
SHD2_k127_6499185_0 Fumarase C C-terminus K01744 - 4.3.1.1 5.763e-231 724.0
SHD2_k127_6499185_1 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 560.0
SHD2_k127_6499185_10 - - - - 0.00000000000000000000000001583 111.0
SHD2_k127_6499185_11 - - - - 0.000000000000000001488 87.0
SHD2_k127_6499185_12 - - - - 0.00000001037 59.0
SHD2_k127_6499185_2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 546.0
SHD2_k127_6499185_3 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 338.0
SHD2_k127_6499185_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 306.0
SHD2_k127_6499185_5 KR domain K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 297.0
SHD2_k127_6499185_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005501 258.0
SHD2_k127_6499185_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000427 243.0
SHD2_k127_6499185_8 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000006666 173.0
SHD2_k127_6499185_9 rRNA (adenine-N6,N6-)-dimethyltransferase activity K02528,K15256 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000000000000000000005377 133.0
SHD2_k127_6532076_0 secondary active sulfate transmembrane transporter activity - - - 1.843e-277 885.0
SHD2_k127_6532076_1 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 438.0
SHD2_k127_6532076_10 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000004889 104.0
SHD2_k127_6532076_11 Thioredoxin-like - - - 0.000000000000000005249 85.0
SHD2_k127_6532076_2 HEAT repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003496 385.0
SHD2_k127_6532076_3 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 306.0
SHD2_k127_6532076_4 Zinc carboxypeptidase K14054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 291.0
SHD2_k127_6532076_5 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001765 256.0
SHD2_k127_6532076_6 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000001939 219.0
SHD2_k127_6532076_7 HEAT repeats - - - 0.0000000000000000000000000000000000000005276 162.0
SHD2_k127_6532076_9 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.00000000000000000000000006885 113.0
SHD2_k127_6545464_0 Arginine deiminase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002722 286.0
SHD2_k127_6545464_1 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000009947 190.0
SHD2_k127_6545464_2 EXOIII K02342 - 2.7.7.7 0.0000000711 58.0
SHD2_k127_6553743_0 OST-HTH/LOTUS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 421.0
SHD2_k127_6553743_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 372.0
SHD2_k127_6558064_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3.265e-263 818.0
SHD2_k127_6558064_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 6.907e-240 752.0
SHD2_k127_6558064_10 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 320.0
SHD2_k127_6558064_11 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 321.0
SHD2_k127_6558064_12 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001619 275.0
SHD2_k127_6558064_13 Lysine methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000008423 220.0
SHD2_k127_6558064_14 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000486 204.0
SHD2_k127_6558064_15 - - - - 0.00000000000000000000000000000000000000000000000000000002802 204.0
SHD2_k127_6558064_16 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000001233 192.0
SHD2_k127_6558064_17 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000000000000000161 164.0
SHD2_k127_6558064_18 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000004424 152.0
SHD2_k127_6558064_19 - - - - 0.0000000000000000000000000000004152 131.0
SHD2_k127_6558064_2 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 8.39e-209 662.0
SHD2_k127_6558064_20 MazG nucleotide pyrophosphohydrolase domain - - - 0.00000000000000000000000004317 111.0
SHD2_k127_6558064_21 - - - - 0.000000000000000000000001344 111.0
SHD2_k127_6558064_22 Methyltransferase domain - - - 0.00000000000000000000002295 109.0
SHD2_k127_6558064_24 permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.00000000007634 64.0
SHD2_k127_6558064_3 C-terminus of AA_permease K03294 - - 2.72e-208 659.0
SHD2_k127_6558064_4 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 474.0
SHD2_k127_6558064_5 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005479 429.0
SHD2_k127_6558064_6 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 415.0
SHD2_k127_6558064_7 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 405.0
SHD2_k127_6558064_8 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 341.0
SHD2_k127_6558064_9 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 346.0
SHD2_k127_6560736_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01466 GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 567.0
SHD2_k127_6560736_1 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 533.0
SHD2_k127_6560736_10 xanthine dehydrogenase activity K13479 - 1.17.1.4 0.00000000002812 64.0
SHD2_k127_6560736_2 Belongs to the allantoicase family K01477 GO:0003674,GO:0003824,GO:0004037,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019439,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 514.0
SHD2_k127_6560736_3 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 514.0
SHD2_k127_6560736_4 Belongs to the HpcH HpaI aldolase family K18292 - 4.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 493.0
SHD2_k127_6560736_5 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 322.0
SHD2_k127_6560736_6 tRNA wobble adenosine to inosine editing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006133 261.0
SHD2_k127_6560736_7 allantoin biosynthetic process K01477,K16840 - 3.5.3.4,4.1.1.97 0.000000000000000000000000000000000000000000001837 172.0
SHD2_k127_6560736_8 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.000000000000000000000000000003336 123.0
SHD2_k127_6560736_9 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000007569 83.0
SHD2_k127_6595363_0 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 367.0
SHD2_k127_6595363_1 lactoylglutathione lyase activity K01239 - 3.2.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000003277 261.0
SHD2_k127_6595363_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001066 237.0
SHD2_k127_6595363_3 Belongs to the thiolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000001089 232.0
SHD2_k127_6595363_4 COG0657 Esterase lipase - - - 0.000000000000000000000000000000000000000000000000000000000002181 219.0
SHD2_k127_6595363_5 - - - - 0.000000000000000000000000000000000004098 141.0
SHD2_k127_6595363_6 - - - - 0.00000000000000000000000000000006099 140.0
SHD2_k127_6595363_7 lactoylglutathione lyase activity - - - 0.0000000000005584 70.0
SHD2_k127_6595363_8 - - - - 0.00001056 58.0
SHD2_k127_6608532_0 transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000002113 216.0
SHD2_k127_6608532_1 Glyoxalase-like domain - - - 0.000000000000000000000000000000000004976 145.0
SHD2_k127_6608532_2 - - - - 0.00009794 52.0
SHD2_k127_6608686_0 IMP dehydrogenase activity K03281 - - 2.836e-239 756.0
SHD2_k127_6608686_1 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 559.0
SHD2_k127_6608686_2 Uncharacterised conserved protein (DUF2156) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 392.0
SHD2_k127_6608686_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 293.0
SHD2_k127_6608686_4 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000004375 228.0
SHD2_k127_6608686_5 methyltransferase activity - - - 0.000000000000000000000000000000009558 133.0
SHD2_k127_6608686_6 - - - - 0.00000000000000000000000000000003349 142.0
SHD2_k127_6608686_7 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000292 115.0
SHD2_k127_6608686_8 - - - - 0.00000000000614 72.0
SHD2_k127_6618999_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 8.204e-228 713.0
SHD2_k127_6618999_1 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 556.0
SHD2_k127_6618999_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 358.0
SHD2_k127_6618999_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004338 282.0
SHD2_k127_6618999_4 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000001558 149.0
SHD2_k127_6623875_0 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 391.0
SHD2_k127_6623875_1 Wzt C-terminal domain K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 365.0
SHD2_k127_6623875_2 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 349.0
SHD2_k127_6623875_3 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 292.0
SHD2_k127_6623875_4 Modulates the polysaccharide chain length of enterobacterial common antigen (ECA) - - - 0.00000000000000000000000000000000000004778 158.0
SHD2_k127_6629339_0 HELICc2 K03722 - 3.6.4.12 1.187e-267 844.0
SHD2_k127_6629339_1 Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 563.0
SHD2_k127_6629339_2 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 296.0
SHD2_k127_6629339_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008034 282.0
SHD2_k127_6629339_4 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000000000000002004 174.0
SHD2_k127_6631309_0 Luciferase-like monooxygenase K17228 - 1.14.14.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008796 542.0
SHD2_k127_6631309_1 Cellulose synthase K00694 - 2.4.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 542.0
SHD2_k127_6631309_2 Carbamoyl-phosphate synthase L chain, ATP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 444.0
SHD2_k127_6631309_3 Glycosyl hydrolase family 26 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 376.0
SHD2_k127_6631309_4 beta-lactamase - - - 0.0000000000000000000000000001726 117.0
SHD2_k127_6631309_5 Cysteine-rich CPXCG - - - 0.000000000000000000008563 94.0
SHD2_k127_6631309_7 Tetratricopeptide repeat - - - 0.0000007785 62.0
SHD2_k127_6641604_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 6.366e-253 785.0
SHD2_k127_6641604_1 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 406.0
SHD2_k127_6641604_2 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000000000000000001366 249.0
SHD2_k127_6641604_3 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000009066 194.0
SHD2_k127_6675364_0 peptidase - - - 1.021e-211 672.0
SHD2_k127_6675364_1 Subtilase family - - - 4.676e-210 681.0
SHD2_k127_6675364_10 PFAM cobalamin synthesis protein P47K K04652 - - 0.000000000000000000000000000000000000000000000000000000000000001107 226.0
SHD2_k127_6675364_11 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.00000000000000000000000009012 114.0
SHD2_k127_6675364_12 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01668 - 4.1.99.2 0.0000000000000001124 81.0
SHD2_k127_6675364_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000222 48.0
SHD2_k127_6675364_2 Belongs to the carbamoyltransferase HypF family K04656 - - 5.213e-205 662.0
SHD2_k127_6675364_3 Rhodanese Homology Domain K01069,K03797 - 3.1.2.6,3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 586.0
SHD2_k127_6675364_4 amino acid K20265 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 484.0
SHD2_k127_6675364_5 Cardiolipin synthetase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 346.0
SHD2_k127_6675364_6 Cytochrome b/b6/petB K00412,K03888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 331.0
SHD2_k127_6675364_7 Doubled CXXCH motif (Paired_CXXCH_1) K08354 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007886 304.0
SHD2_k127_6675364_8 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001649 258.0
SHD2_k127_6675364_9 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.00000000000000000000000000000000000000000000000000000000000000000002377 259.0
SHD2_k127_6686826_0 Sodium:dicarboxylate symporter family K11103 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003613 580.0
SHD2_k127_6686826_1 Glycosyl hydrolase family 20, domain 2 K12373 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000001253 246.0
SHD2_k127_6686826_2 protein kinase activity - - - 0.000000000000000000000000000000000000000006952 158.0
SHD2_k127_6701531_0 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000004734 239.0
SHD2_k127_6701531_1 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000000000000000000001179 143.0
SHD2_k127_6701531_3 - - - - 0.00000003533 63.0
SHD2_k127_6721520_0 Transcriptional regulatory protein, C terminal K07665 - - 0.00000000000000000000000000000000000000000000000000000001448 201.0
SHD2_k127_6721520_1 - - - - 0.00000000461 58.0
SHD2_k127_6744514_0 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 8.414e-252 788.0
SHD2_k127_6744514_1 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000002452 143.0
SHD2_k127_6744514_2 Regulatory protein, FmdB family - - - 0.000000313 56.0
SHD2_k127_6825454_0 lysine biosynthetic process via aminoadipic acid - - - 7.182e-296 934.0
SHD2_k127_6825454_1 cytochrome C peroxidase - - - 7.751e-253 790.0
SHD2_k127_6825454_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 502.0
SHD2_k127_6825454_3 Sodium:dicarboxylate symporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007811 357.0
SHD2_k127_6825454_4 zinc D-Ala-D-Ala carboxypeptidase activity K08641 - 3.4.13.22 0.000000000000000000000000000000000000000000000000000000000000000000000000002911 258.0
SHD2_k127_6825454_5 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007661 240.0
SHD2_k127_6825454_6 Nicotinamide mononucleotide transporter K03811 - - 0.000000000000000000000000000000000000000000000000000000000000000004858 230.0
SHD2_k127_6825454_7 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000008328 205.0
SHD2_k127_6825454_9 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000001988 106.0
SHD2_k127_6848532_0 carbamoyl transferase, NodU family K00612 - - 3.028e-207 659.0
SHD2_k127_6848532_1 PFAM ABC transporter related K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 445.0
SHD2_k127_6848532_10 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000001251 176.0
SHD2_k127_6848532_11 - - - - 0.00000000000000000000000000000000000004032 161.0
SHD2_k127_6848532_12 Male sterility protein - - - 0.000000000000000000000000000000001362 132.0
SHD2_k127_6848532_13 Glycosyl transferases group 1 K19424 GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 - 0.000000000000000000000008199 114.0
SHD2_k127_6848532_14 O-methyltransferase activity - - - 0.000000000000000008715 92.0
SHD2_k127_6848532_15 Polysaccharide biosynthesis/export protein - - - 0.0002743 47.0
SHD2_k127_6848532_2 asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 417.0
SHD2_k127_6848532_3 PFAM ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 386.0
SHD2_k127_6848532_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004083 369.0
SHD2_k127_6848532_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 313.0
SHD2_k127_6848532_6 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 301.0
SHD2_k127_6848532_7 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008352 304.0
SHD2_k127_6848532_8 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001116 276.0
SHD2_k127_6848532_9 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000008397 177.0
SHD2_k127_6914122_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.66e-215 675.0
SHD2_k127_6914122_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 3.162e-199 629.0
SHD2_k127_6914122_10 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000001668 196.0
SHD2_k127_6914122_11 - - - - 0.00000000000000000000000000000000000000000000000002126 182.0
SHD2_k127_6914122_13 Septum formation initiator K05589 - - 0.0000000000000000008653 89.0
SHD2_k127_6914122_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 561.0
SHD2_k127_6914122_3 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 512.0
SHD2_k127_6914122_4 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 430.0
SHD2_k127_6914122_5 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 397.0
SHD2_k127_6914122_6 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 296.0
SHD2_k127_6914122_7 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000002506 276.0
SHD2_k127_6914122_8 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000004864 232.0
SHD2_k127_6914122_9 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000003615 224.0
SHD2_k127_6943504_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 3.018e-197 629.0
SHD2_k127_6943504_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 568.0
SHD2_k127_6943504_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 472.0
SHD2_k127_6959429_0 lysine biosynthetic process via aminoadipic acid - - - 0.0 1086.0
SHD2_k127_6959429_1 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 560.0
SHD2_k127_6959429_10 Belongs to the binding-protein-dependent transport system permease family K05832 - - 0.000000000000000000000000000000000000000000000000000000000000000001924 251.0
SHD2_k127_6959429_11 - - - - 0.00000000000000000000000000000000000000000000000000000004836 212.0
SHD2_k127_6959429_12 Cupin domain - - - 0.00000000000000000000000000000000000000000000000747 175.0
SHD2_k127_6959429_13 negative regulation of transcription, DNA-templated - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000002201 156.0
SHD2_k127_6959429_14 Bacterial transcription activator, effector binding domain - - - 0.0000000000000000000000001156 115.0
SHD2_k127_6959429_15 Psort location Periplasmic, score K09807 - - 0.000000000000001594 86.0
SHD2_k127_6959429_16 PFAM YceI-like domain - - - 0.0000000007148 69.0
SHD2_k127_6959429_2 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 518.0
SHD2_k127_6959429_3 PFAM Beta-lactamase K18988 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 415.0
SHD2_k127_6959429_4 -O-antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 389.0
SHD2_k127_6959429_5 LysM domain K13735 GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 371.0
SHD2_k127_6959429_6 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 314.0
SHD2_k127_6959429_7 proteinase inhibitor I4 serpin K13963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 310.0
SHD2_k127_6959429_8 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009257 304.0
SHD2_k127_6959429_9 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 295.0
SHD2_k127_6983099_0 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004738 352.0
SHD2_k127_6983099_1 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 292.0
SHD2_k127_6983099_2 - - - - 0.0000000000000000000000000000000001087 143.0
SHD2_k127_6983099_3 - - - - 0.0000000000000006461 83.0
SHD2_k127_7016598_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000003647 214.0
SHD2_k127_7016598_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000003226 62.0
SHD2_k127_7035638_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 7.203e-235 737.0
SHD2_k127_7035638_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.148e-225 707.0
SHD2_k127_7035638_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 550.0
SHD2_k127_7035638_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 313.0
SHD2_k127_7035638_4 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003078 271.0
SHD2_k127_7035638_5 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000004823 249.0
SHD2_k127_7035638_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000773 166.0
SHD2_k127_7035638_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000005056 130.0
SHD2_k127_7043179_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 378.0
SHD2_k127_7043179_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000000001207 239.0
SHD2_k127_7043179_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000003528 213.0
SHD2_k127_7149847_0 Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase K07257 - - 0.00000000000000000000000000000000000000000000000000000000000004361 222.0
SHD2_k127_7149847_1 Cytidylyltransferase - - - 0.00000000000000000000000000000000000000000000000000003893 194.0
SHD2_k127_7149847_2 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000001644 141.0
SHD2_k127_7231991_0 Insulinase (Peptidase family M16) K07263 - - 1.196e-274 875.0
SHD2_k127_7231991_1 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 404.0
SHD2_k127_7231991_10 GCN5-related N-acetyl-transferase K06975 - - 0.0000000000000000000001146 104.0
SHD2_k127_7231991_11 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000002829 97.0
SHD2_k127_7231991_12 Domain of unknown function (DUF4342) - - - 0.0000000000000005708 81.0
SHD2_k127_7231991_13 - - - - 0.000000000000003585 81.0
SHD2_k127_7231991_2 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002039 249.0
SHD2_k127_7231991_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002395 243.0
SHD2_k127_7231991_4 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000003181 217.0
SHD2_k127_7231991_5 - - - - 0.00000000000000000000000000000000000000000000000000004402 198.0
SHD2_k127_7231991_6 - - - - 0.000000000000000000000000000000000000000000000001157 191.0
SHD2_k127_7231991_7 - - - - 0.000000000000000000000000001223 123.0
SHD2_k127_7231991_8 Putative adhesin - - - 0.000000000000000000000002941 115.0
SHD2_k127_7274156_0 Rieske (2fe-2S) K00499 - 1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 451.0
SHD2_k127_7274156_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000007782 227.0
SHD2_k127_7341439_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 426.0
SHD2_k127_7341439_1 P2 response regulator binding domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 297.0
SHD2_k127_7341439_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000000000000000000000000000000000000000004234 233.0
SHD2_k127_7341439_3 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000001768 210.0
SHD2_k127_7341439_4 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000000000000000001038 147.0
SHD2_k127_7341439_5 PFAM CheW domain protein - - - 0.00000000000002333 81.0
SHD2_k127_7378437_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1399.0
SHD2_k127_7378437_1 metal ion transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 493.0
SHD2_k127_7378437_2 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 464.0
SHD2_k127_7378437_3 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000005963 180.0
SHD2_k127_7378437_4 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.00000000000000000000006477 100.0
SHD2_k127_7401997_0 Nitronate monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009448 589.0
SHD2_k127_7401997_1 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008034 282.0
SHD2_k127_7401997_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000671 240.0
SHD2_k127_7401997_3 DinB family - - - 0.00000000000000000000000000000000000000000000000000000006493 202.0
SHD2_k127_7401997_4 - - - - 0.00000000000000000000000000000000000434 143.0
SHD2_k127_7401997_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000001441 108.0
SHD2_k127_7401997_6 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 0.000000000000000003075 87.0
SHD2_k127_7407881_0 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000938 612.0
SHD2_k127_7407881_1 Protein kinase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008215 348.0
SHD2_k127_7412494_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 6.496e-265 824.0
SHD2_k127_7412494_1 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.432e-229 728.0
SHD2_k127_7412494_2 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 444.0
SHD2_k127_7412494_3 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 416.0
SHD2_k127_7412494_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00210,K00220,K00800 - 1.3.1.12,1.3.1.43,2.5.1.19 0.0000000000000000000000000000000003079 143.0
SHD2_k127_7412494_5 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000006894 139.0
SHD2_k127_7412494_6 prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000003607 75.0
SHD2_k127_7412494_7 FeoA K04758 - - 0.00000000004738 68.0
SHD2_k127_7420642_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 413.0
SHD2_k127_7420642_1 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 416.0
SHD2_k127_7420642_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800,K00945 - 2.5.1.19,2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 413.0
SHD2_k127_7420642_3 Amino acid kinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 366.0
SHD2_k127_7420642_4 Bacterial membrane protein YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 377.0
SHD2_k127_7420642_5 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 308.0
SHD2_k127_7420642_6 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000008754 244.0
SHD2_k127_7423980_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 8.264e-266 824.0
SHD2_k127_7423980_1 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 325.0
SHD2_k127_7423980_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 311.0
SHD2_k127_7423980_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000001106 76.0
SHD2_k127_7423980_4 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000009315 62.0
SHD2_k127_7430402_0 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 0.0 1021.0
SHD2_k127_7430402_1 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 537.0
SHD2_k127_7430402_2 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003939 443.0
SHD2_k127_7430402_3 Bacterial transferase hexapeptide (six repeats) K02617 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 280.0
SHD2_k127_7430402_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000000000000000000000000000000000001074 167.0
SHD2_k127_7430402_5 Protein of unknown function, DUF - - - 0.0000000000000000000000000000000000000006579 154.0
SHD2_k127_7457524_0 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006418 586.0
SHD2_k127_7457524_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 576.0
SHD2_k127_7457524_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 541.0
SHD2_k127_7467363_0 FtsX-like permease family K02004 - - 2.357e-267 850.0
SHD2_k127_7467363_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 344.0
SHD2_k127_7467363_2 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001104 267.0
SHD2_k127_7467363_3 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000005698 216.0
SHD2_k127_7467363_4 PFAM Resolvase, N-terminal - - - 0.0008282 42.0
SHD2_k127_7472854_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009571 467.0
SHD2_k127_7472854_1 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 330.0
SHD2_k127_7472854_2 Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily K01911 - 6.2.1.26 0.0000000000000000000000000000000000000000000001265 175.0
SHD2_k127_7501955_0 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006104 599.0
SHD2_k127_7501955_1 Two component, sigma54 specific, transcriptional regulator, Fis family K02667,K07713,K07714,K19641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 455.0
SHD2_k127_7501955_2 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006971 437.0
SHD2_k127_7501955_3 PAS domain K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000003824 271.0
SHD2_k127_7501955_4 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000002137 191.0
SHD2_k127_7501955_5 Peptidase family M48 - - - 0.00000000000000000000000000000000000006802 147.0
SHD2_k127_7501955_6 Transmembrane and - - - 0.0000000000000000000000000000000344 145.0
SHD2_k127_7501955_7 Transmembrane and TPR repeat-containing protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827 - 0.00000000000000000000000000004501 134.0
SHD2_k127_7501955_8 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.000000000000000004563 88.0
SHD2_k127_7503000_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.106e-295 911.0
SHD2_k127_7503000_1 Bacterial membrane protein YfhO - - - 5.341e-251 801.0
SHD2_k127_7503000_11 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000000000002812 205.0
SHD2_k127_7503000_12 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000622 186.0
SHD2_k127_7503000_13 Lipopolysaccharide-assembly, LptC-related - - - 0.00000000000000000000000000000000000000001105 161.0
SHD2_k127_7503000_2 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 6.303e-248 773.0
SHD2_k127_7503000_3 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 518.0
SHD2_k127_7503000_4 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 450.0
SHD2_k127_7503000_5 SIS domain K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 407.0
SHD2_k127_7503000_6 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 390.0
SHD2_k127_7503000_7 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 363.0
SHD2_k127_7503000_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 342.0
SHD2_k127_7503000_9 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001757 285.0
SHD2_k127_7511863_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.833e-254 795.0
SHD2_k127_7511863_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009624 509.0
SHD2_k127_7511863_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 340.0
SHD2_k127_7511863_3 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001249 267.0
SHD2_k127_7511863_4 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000000000000000000000000000000003104 230.0
SHD2_k127_7511863_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000001519 109.0
SHD2_k127_7512609_0 Sodium:solute symporter family K14392 - - 1.976e-227 713.0
SHD2_k127_7512609_1 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006844 523.0
SHD2_k127_7512609_2 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 511.0
SHD2_k127_7512609_3 helix_turn _helix lactose operon repressor K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 381.0
SHD2_k127_7512609_4 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 312.0
SHD2_k127_7512609_5 Dehydratase - - - 0.000000000000000000000000000000001044 133.0
SHD2_k127_7512609_6 - - - - 0.000000000000000000000000000000001079 137.0
SHD2_k127_7522763_0 Flavin containing amine oxidoreductase - - - 2.82e-198 631.0
SHD2_k127_7522763_1 Cytidylate kinase K00876 - 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009506 293.0
SHD2_k127_7522763_2 Ferric reductase like transmembrane component - - - 0.0000000000000000000000004738 110.0
SHD2_k127_7522763_3 - - - - 0.000000000000000000000008235 107.0
SHD2_k127_7522763_4 Transcription factor zinc-finger K09981 - - 0.0000000000000000000001007 101.0
SHD2_k127_7522763_5 Flavin containing amine oxidoreductase - - - 0.000001734 56.0
SHD2_k127_7548290_0 Enoyl-(Acyl carrier protein) reductase K00023,K00059 - 1.1.1.100,1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000007044 256.0
SHD2_k127_7548290_1 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.00000000000000000000000000000000000000000000000001808 181.0
SHD2_k127_7548290_2 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.0000000000000000000000000000000000000000000003264 177.0
SHD2_k127_7554075_0 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 364.0
SHD2_k127_7554075_1 Pfam:DUF59 K02612 - - 0.000000000000000000000000000000000000000000000000000233 190.0
SHD2_k127_7554075_2 Phenylacetic acid degradation B K02610 - - 0.00000000000000000000000000000000000000000005461 162.0
SHD2_k127_7570645_0 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006861 294.0
SHD2_k127_7570645_1 Putative glycosyl hydrolase domain - - - 0.0000000000000005452 87.0
SHD2_k127_7575977_0 Enoyl-CoA hydratase/isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000767 557.0
SHD2_k127_7575977_1 Zn_pept - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 509.0
SHD2_k127_7575977_2 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 431.0
SHD2_k127_7575977_3 - - - - 0.000000000000000000000000000001119 128.0
SHD2_k127_7577434_0 Phosphoglucose isomerase K01810 - 5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009784 559.0
SHD2_k127_7577434_1 Fructose-bisphosphate aldolase class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 482.0
SHD2_k127_7652007_0 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003987 274.0
SHD2_k127_7652007_1 CYTH domain K01768,K05873 - 4.6.1.1 0.0000000000000000000000000000000000000000000000005483 181.0
SHD2_k127_7652007_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000002162 144.0
SHD2_k127_7657042_0 protease with the C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006712 250.0
SHD2_k127_7657042_1 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000002748 191.0
SHD2_k127_7660160_0 Glycosyl hydrolases family 18 - - - 0.0 1153.0
SHD2_k127_7660160_1 Penicillin amidase K01434 - 3.5.1.11 4.276e-279 876.0
SHD2_k127_7660160_10 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000004972 179.0
SHD2_k127_7660160_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000003333 179.0
SHD2_k127_7660160_12 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000166 173.0
SHD2_k127_7660160_13 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000007464 166.0
SHD2_k127_7660160_14 Protein of unknown function (DUF3303) - - - 0.0000000000000000000000000000000000001092 144.0
SHD2_k127_7660160_15 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000005689 135.0
SHD2_k127_7660160_16 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.00000000000000000000000000000002058 129.0
SHD2_k127_7660160_17 YCII-related domain - - - 0.00000000000000000000000000000002728 130.0
SHD2_k127_7660160_18 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000001909 124.0
SHD2_k127_7660160_19 Cupin 2, conserved barrel domain protein K07155 - 1.13.11.24 0.0000000000000000000000001835 111.0
SHD2_k127_7660160_2 Carbohydrate family 9 binding domain-like - - - 6.836e-240 768.0
SHD2_k127_7660160_20 DNA-binding transcription factor activity - - - 0.0000000000000000000000002916 115.0
SHD2_k127_7660160_22 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000006594 108.0
SHD2_k127_7660160_23 - - - - 0.0000000000000000008015 92.0
SHD2_k127_7660160_24 Activator of Hsp90 ATPase - - - 0.000000000000000007257 83.0
SHD2_k127_7660160_25 - - - - 0.0000000000009499 70.0
SHD2_k127_7660160_26 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000005219 53.0
SHD2_k127_7660160_27 gag-polyprotein putative aspartyl protease - - - 0.0003521 51.0
SHD2_k127_7660160_3 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008625 389.0
SHD2_k127_7660160_4 enterobactin catabolic process K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 343.0
SHD2_k127_7660160_5 epimerase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 325.0
SHD2_k127_7660160_6 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 306.0
SHD2_k127_7660160_7 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003028 270.0
SHD2_k127_7660160_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000000000003143 203.0
SHD2_k127_7660160_9 creatininase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000001187 201.0
SHD2_k127_7662775_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008843 331.0
SHD2_k127_7662775_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000009832 216.0
SHD2_k127_7662775_2 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000009785 204.0
SHD2_k127_7662775_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000005754 159.0
SHD2_k127_7662775_4 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000003643 152.0
SHD2_k127_7662775_5 - - - - 0.00000000000000000000000000000008902 131.0
SHD2_k127_7662775_6 Glycosyl transferase 4-like K00754 - - 0.000000000608 61.0
SHD2_k127_7670539_0 ABC transporter C-terminal domain K15738 - - 3.091e-267 835.0
SHD2_k127_7670539_1 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 551.0
SHD2_k127_7670539_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 462.0
SHD2_k127_7670539_3 - - - - 0.0000000000000000000000000000000000000000000000000000000001529 207.0
SHD2_k127_7674516_0 Belongs to the DegT DnrJ EryC1 family K12452 - 1.17.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008145 559.0
SHD2_k127_7674516_1 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 445.0
SHD2_k127_7674516_2 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003791 285.0
SHD2_k127_7674516_3 GDP-mannose 4,6 dehydratase - - - 0.00000000000000000000004705 104.0
SHD2_k127_7677426_0 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004052 359.0
SHD2_k127_7677426_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000009904 264.0
SHD2_k127_7677426_2 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000006401 215.0
SHD2_k127_7677426_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000000003182 207.0
SHD2_k127_7677426_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000000000000000003689 160.0
SHD2_k127_7677426_5 Ribosomal protein S16 K02959 - - 0.000000000000000000000000000000001716 132.0
SHD2_k127_7692049_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 593.0
SHD2_k127_7692049_1 Domain of unknown function (DUF4198) - - - 0.00000000000000000000000000000000000000000000000001168 190.0
SHD2_k127_7692049_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000002737 105.0
SHD2_k127_7692049_3 CHRD domain - - - 0.0000000000000001578 85.0
SHD2_k127_7694857_0 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 439.0
SHD2_k127_7694857_1 CcmB protein K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 308.0
SHD2_k127_7694857_2 Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006399 304.0
SHD2_k127_7694857_3 ABC transporter K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000002509 240.0
SHD2_k127_7709586_0 Esterase of the alpha-beta hydrolase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 484.0
SHD2_k127_7709586_1 domain, Protein K03455 - - 0.000000000000001074 80.0
SHD2_k127_7721739_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 2.389e-245 770.0
SHD2_k127_7721739_1 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000001005 173.0
SHD2_k127_7788597_0 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 296.0
SHD2_k127_7788597_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001593 226.0
SHD2_k127_7788597_2 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000006251 130.0
SHD2_k127_7792499_0 beta-galactosidase activity K15855 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575 3.2.1.165 0.0 1347.0
SHD2_k127_7792499_1 Sortilin, neurotensin receptor 3, - - - 0.0 1111.0
SHD2_k127_7792499_10 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 295.0
SHD2_k127_7792499_11 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002989 260.0
SHD2_k127_7792499_12 Belongs to the MenA family. Type 1 subfamily K02548 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000005181 239.0
SHD2_k127_7792499_13 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000002506 205.0
SHD2_k127_7792499_14 transcription factor binding - - - 0.000000000000000000000000000000000000000000000000008436 186.0
SHD2_k127_7792499_15 - - - - 0.000000000000000000000000000000000000000000000003461 180.0
SHD2_k127_7792499_16 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000002149 179.0
SHD2_k127_7792499_17 Leishmanolysin - - - 0.0000000000000000000000000000000000000531 163.0
SHD2_k127_7792499_19 SnoaL-like polyketide cyclase - - - 0.0000000000000000000001661 102.0
SHD2_k127_7792499_2 ABC transporter K06020 - 3.6.3.25 1.403e-258 807.0
SHD2_k127_7792499_21 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity K13991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464 - 0.00000000000000000087 97.0
SHD2_k127_7792499_22 Haem-binding domain - - - 0.000000000000000002414 93.0
SHD2_k127_7792499_23 DinB family - - - 0.000000000000000005527 87.0
SHD2_k127_7792499_24 Cupin domain - - - 0.000000000000006875 79.0
SHD2_k127_7792499_25 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000009715 86.0
SHD2_k127_7792499_26 CHASE3 domain - - - 0.00000005216 61.0
SHD2_k127_7792499_27 - - - - 0.0000001736 60.0
SHD2_k127_7792499_28 - - - - 0.0002362 49.0
SHD2_k127_7792499_3 Amino acid permease K03294,K19540 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - 8.798e-249 773.0
SHD2_k127_7792499_4 lysine biosynthetic process via aminoadipic acid - - - 3.206e-204 667.0
SHD2_k127_7792499_5 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 545.0
SHD2_k127_7792499_6 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 468.0
SHD2_k127_7792499_7 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009424 460.0
SHD2_k127_7792499_8 Na H antiporter K03315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 449.0
SHD2_k127_7792499_9 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 332.0
SHD2_k127_7823912_0 dehydrogenase, E1 component K11381 - 1.2.4.4 9.618e-310 963.0
SHD2_k127_7823912_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 431.0
SHD2_k127_7823912_2 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00658 - 2.3.1.61 0.000002599 50.0
SHD2_k127_7824259_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 1.01e-200 631.0
SHD2_k127_7824259_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 484.0
SHD2_k127_7824259_10 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000000000001491 154.0
SHD2_k127_7824259_11 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.000000000000000000000000000000854 125.0
SHD2_k127_7824259_12 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000015 115.0
SHD2_k127_7824259_2 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 478.0
SHD2_k127_7824259_3 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 382.0
SHD2_k127_7824259_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 335.0
SHD2_k127_7824259_5 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009171 318.0
SHD2_k127_7824259_6 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 287.0
SHD2_k127_7824259_7 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002192 268.0
SHD2_k127_7824259_8 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000009993 257.0
SHD2_k127_7824259_9 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000001734 231.0
SHD2_k127_7862486_0 Required for chromosome condensation and partitioning K03529 - - 4.648e-248 792.0
SHD2_k127_7862486_1 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 402.0
SHD2_k127_7862486_2 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005637 242.0
SHD2_k127_7862486_3 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000003439 84.0
SHD2_k127_7885179_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 453.0
SHD2_k127_7885179_1 Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) K08680 - 4.2.99.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002518 276.0
SHD2_k127_7885179_2 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.0000000000000000000000000000000000000000000000000000000000004173 214.0
SHD2_k127_7907376_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 9.943e-300 929.0
SHD2_k127_7907376_1 Protein of unknown function (DUF512) - - - 3.645e-198 624.0
SHD2_k127_7907376_2 MviN-like protein K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 597.0
SHD2_k127_7907376_3 Bacillithiol biosynthesis BshC K22136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 415.0
SHD2_k127_7907376_4 Tellurite resistance protein TehB - - - 0.00000000000000000000000002718 112.0
SHD2_k127_7921730_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 466.0
SHD2_k127_7921730_1 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000000000000005886 202.0
SHD2_k127_7921730_2 Ribosomal protein S21 K02970 - - 0.000000000000000000000008454 100.0
SHD2_k127_7932443_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 525.0
SHD2_k127_7932443_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000001098 143.0
SHD2_k127_8087638_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 1.896e-205 644.0
SHD2_k127_8087638_1 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004063 305.0
SHD2_k127_8087638_2 4Fe-4S binding domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000006044 222.0
SHD2_k127_8127119_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 6.022e-272 872.0
SHD2_k127_8127119_1 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 427.0
SHD2_k127_8127119_2 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 324.0
SHD2_k127_8127119_3 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 300.0
SHD2_k127_8127119_4 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000002209 255.0
SHD2_k127_8127119_5 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002598 248.0
SHD2_k127_8127119_6 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001487 254.0
SHD2_k127_8176999_0 PQQ enzyme repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 532.0
SHD2_k127_8176999_1 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000611 76.0
SHD2_k127_8176999_2 Glucose / Sorbosone dehydrogenase - - - 0.00000006263 64.0
SHD2_k127_82065_0 Aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 524.0
SHD2_k127_82065_1 cobalamin binding K22491 - - 0.00000000000000000000000000000000000000000000000008071 189.0
SHD2_k127_82065_2 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.0000000000000000000000000000000000000000000000001318 183.0
SHD2_k127_82065_3 Iron-regulated membrane protein K00380 - 1.8.1.2 0.00000000000000000000000000000000000000000001726 174.0
SHD2_k127_82065_4 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000001139 163.0
SHD2_k127_82065_5 CYTH - - - 0.000000000000000000000000000000000005004 149.0
SHD2_k127_8211375_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 290.0
SHD2_k127_8211375_1 - - - - 0.0000000000000000000000000000002883 137.0
SHD2_k127_8213386_0 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000004112 264.0
SHD2_k127_8213386_1 Glutamate-cysteine ligase family 2(GCS2) K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000002475 192.0
SHD2_k127_8213386_2 ABC transporter K05847 GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337 - 0.00000000000000000000000006173 111.0
SHD2_k127_8222612_0 Glycosyl transferase family group 2 - - - 0.0000000000000000000000000000000000006355 153.0
SHD2_k127_8222612_1 xylanase chitin deacetylase - - - 0.000000000000000000000000002284 126.0
SHD2_k127_8222612_2 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000003387 113.0
SHD2_k127_8222612_3 Glycosyltransferase like family 2 - - - 0.0000000000000000000000001108 118.0
SHD2_k127_8222612_4 Glycosyltransferase like family 2 - - - 0.000000000000000008928 95.0
SHD2_k127_8222612_5 Glycosyl transferases group 1 - - - 0.0000002232 60.0
SHD2_k127_8280666_0 PFAM Acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000006524 241.0
SHD2_k127_8280666_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001492 226.0
SHD2_k127_8280666_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000001136 130.0
SHD2_k127_8297150_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1331.0
SHD2_k127_8297150_1 PFAM ABC transporter transmembrane K06147 - - 7.91e-282 876.0
SHD2_k127_8297150_10 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 306.0
SHD2_k127_8297150_11 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 294.0
SHD2_k127_8297150_12 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 291.0
SHD2_k127_8297150_13 coagulation factor 5 8 type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002637 265.0
SHD2_k127_8297150_14 - - - - 0.0000000000000000000000000000000000000000000000000000000003988 218.0
SHD2_k127_8297150_15 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000001421 158.0
SHD2_k127_8297150_16 Belongs to the peptidase S51 family K13282 - 3.4.15.6 0.00000000000000000000000000000000000004472 155.0
SHD2_k127_8297150_17 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000000003138 153.0
SHD2_k127_8297150_18 Transglycosylase associated protein - - - 0.00000000000000000000000000000009551 126.0
SHD2_k127_8297150_19 RimK-like ATP-grasp domain K03802 - 6.3.2.29,6.3.2.30 0.000000000000000000000000000009563 132.0
SHD2_k127_8297150_2 Mur ligase family, glutamate ligase domain K03802 - 6.3.2.29,6.3.2.30 1.225e-246 789.0
SHD2_k127_8297150_20 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000001872 123.0
SHD2_k127_8297150_21 Belongs to the bacterial solute-binding protein 9 family - - - 0.0000000000000000000000007823 108.0
SHD2_k127_8297150_22 RF-1 domain K15034 - - 0.00000000000000000000003728 104.0
SHD2_k127_8297150_23 - - - - 0.00000000000004092 82.0
SHD2_k127_8297150_24 PFAM S23 ribosomal protein - - - 0.0000001529 59.0
SHD2_k127_8297150_3 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 7.512e-209 657.0
SHD2_k127_8297150_4 - - - - 4.646e-200 648.0
SHD2_k127_8297150_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 416.0
SHD2_k127_8297150_6 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 379.0
SHD2_k127_8297150_7 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 362.0
SHD2_k127_8297150_8 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009581 336.0
SHD2_k127_8297150_9 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 318.0
SHD2_k127_8318272_0 4-amino-4-deoxy-L-arabinose transferase activity K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000001843 209.0
SHD2_k127_8318272_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000001289 199.0
SHD2_k127_8318272_2 It is involved in the biological process described with transmembrane transport K02021,K05657,K19762 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006605,GO:0006626,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006810,GO:0006839,GO:0006886,GO:0006950,GO:0006986,GO:0006996,GO:0007005,GO:0008104,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010033,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017038,GO:0017111,GO:0018130,GO:0019438,GO:0019866,GO:0022804,GO:0022857,GO:0030150,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031966,GO:0031967,GO:0031975,GO:0032592,GO:0033013,GO:0033014,GO:0033036,GO:0033365,GO:0033554,GO:0034514,GO:0034613,GO:0034620,GO:0034641,GO:0035966,GO:0035967,GO:0042168,GO:0042221,GO:0042440,GO:0042623,GO:0042626,GO:0042802,GO:0042803,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044743,GO:0045184,GO:0046148,GO:0046483,GO:0046907,GO:0046983,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051641,GO:0051649,GO:0051716,GO:0055085,GO:0065002,GO:0070585,GO:0070727,GO:0070887,GO:0071310,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072655,GO:0098573,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1990542 - 0.000000001938 59.0
SHD2_k127_8355427_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008945 593.0
SHD2_k127_8355427_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000005459 228.0
SHD2_k127_8371668_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 7.998e-232 732.0
SHD2_k127_8371668_1 Glycosyl transferase 4-like K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 541.0
SHD2_k127_8371668_2 von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 496.0
SHD2_k127_8371668_3 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 432.0
SHD2_k127_8371668_4 Protein of unknown function (DUF1194) K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 424.0
SHD2_k127_8371668_5 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 344.0
SHD2_k127_8371668_6 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000006293 162.0
SHD2_k127_8371668_7 - - - - 0.00000000000000000000000000000000000002296 156.0
SHD2_k127_8371668_8 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000002134 91.0
SHD2_k127_8398403_0 Carboxypeptidase regulatory-like domain - - - 0.0 1473.0
SHD2_k127_8398403_1 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 571.0
SHD2_k127_8398403_11 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.000000000000000000000000000004377 125.0
SHD2_k127_8398403_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 401.0
SHD2_k127_8398403_3 Sugar (and other) transporter K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 342.0
SHD2_k127_8398403_4 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005531 299.0
SHD2_k127_8398403_5 Protein of unknown function (DUF541) K09797 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 289.0
SHD2_k127_8398403_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000001043 254.0
SHD2_k127_8398403_7 - K21429 - - 0.0000000000000000000000000000000000000000000000000000000000000000002571 234.0
SHD2_k127_8398403_8 Domain of unknown function (DUF4186) - - - 0.000000000000000000000000000000000000000000000000006081 182.0
SHD2_k127_8398403_9 - - - - 0.000000000000000000000000000000000000000000001242 172.0
SHD2_k127_88268_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 419.0
SHD2_k127_88268_1 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000001486 265.0
SHD2_k127_88268_2 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000008051 232.0
SHD2_k127_896742_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 2.32e-321 1002.0
SHD2_k127_896742_1 Aldehyde dehydrogenase family K00294 - 1.2.1.88 2.052e-254 796.0
SHD2_k127_896742_10 - - - - 0.00000000000000000000000000000003686 133.0
SHD2_k127_896742_2 coagulation factor 5 8 type - - - 2.273e-223 722.0
SHD2_k127_896742_3 TonB-dependent receptor - - - 2.63e-222 723.0
SHD2_k127_896742_4 Putative glucoamylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 604.0
SHD2_k127_896742_5 ABC transporter substrate-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004678 460.0
SHD2_k127_896742_6 transmembrane transport K02025,K15771 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 404.0
SHD2_k127_896742_7 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 362.0
SHD2_k127_896742_8 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 349.0
SHD2_k127_896742_9 Transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 323.0
SHD2_k127_93618_0 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 393.0
SHD2_k127_93618_1 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000527 254.0
SHD2_k127_93618_2 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000000009486 152.0
SHD2_k127_93618_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000004287 53.0