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Overview

ID MAG03396
Name SHD3_bin.6
Sample SMP0084
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA288
Species
Assembly information
Completeness (%) 69.79
Contamination (%) 1.31
GC content (%) 69.0
N50 (bp) 4,653
Genome size (bp) 1,578,995

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1773

Gene name Description KEGG GOs EC E-value Score Sequence
SHD3_k127_102589_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 483.0
SHD3_k127_102589_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 469.0
SHD3_k127_102589_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 317.0
SHD3_k127_102589_3 HTH-type transcriptional regulatory protein K07728 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 316.0
SHD3_k127_102589_4 Anaerobic ribonucleoside-triphosphate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000004225 231.0
SHD3_k127_102589_5 Hypothetical methyltransferase - - - 0.0006424 50.0
SHD3_k127_103133_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 301.0
SHD3_k127_103133_1 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000005617 84.0
SHD3_k127_1062871_0 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000003692 232.0
SHD3_k127_1062871_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.000000000000000000000001056 108.0
SHD3_k127_1062871_2 CBS domain containing protein - - - 0.0000000000000000000008254 95.0
SHD3_k127_1067936_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006168 603.0
SHD3_k127_1067936_1 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000000000006187 235.0
SHD3_k127_1089076_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 525.0
SHD3_k127_1089076_1 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004602 273.0
SHD3_k127_1089076_2 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000004481 246.0
SHD3_k127_1089076_3 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000001061 233.0
SHD3_k127_1089076_4 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000000001291 194.0
SHD3_k127_1089076_5 PFAM Thioredoxin K03671 - - 0.00000000000000000000000000000000000000003542 154.0
SHD3_k127_1089076_6 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000003161 119.0
SHD3_k127_1089076_7 chorismate mutase K04093 - 5.4.99.5 0.00000000000000000000008142 102.0
SHD3_k127_1089321_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1603.0
SHD3_k127_1089321_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 4.047e-199 634.0
SHD3_k127_1089321_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000358 297.0
SHD3_k127_109369_0 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000001881 255.0
SHD3_k127_109369_1 Domain of unknown function (DUF1917) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006855 245.0
SHD3_k127_109369_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.00000000000000000000000949 102.0
SHD3_k127_109369_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.0000000000000000000001267 96.0
SHD3_k127_1094909_0 COG1045 Serine acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000002752 212.0
SHD3_k127_1094909_1 PKD domain - - - 0.0000001977 63.0
SHD3_k127_1094909_2 - - - - 0.00002448 57.0
SHD3_k127_1095637_0 PFAM Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 567.0
SHD3_k127_1095637_1 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 362.0
SHD3_k127_1095637_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 331.0
SHD3_k127_1095637_3 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000245 275.0
SHD3_k127_1095637_4 PFAM regulatory protein AsnC Lrp family - - - 0.00000000000000000000000000000000000000000000000000003208 201.0
SHD3_k127_1095637_5 Cupin domain - - - 0.000000000000000265 84.0
SHD3_k127_1095637_6 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000007805 87.0
SHD3_k127_1095637_7 Protein of unknown function (DUF2953) - - - 0.000000000000421 78.0
SHD3_k127_1113381_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 475.0
SHD3_k127_1113381_1 Gnat family - - - 0.0000000000000000000000000000000000000000000000001835 181.0
SHD3_k127_1113381_2 protein possibly involved in aromatic compounds catabolism K02614 - - 0.00000000000000000000001339 106.0
SHD3_k127_1113381_3 - - - - 0.0000000002888 72.0
SHD3_k127_1117975_0 DEAD DEAH box helicase domain protein K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007139 342.0
SHD3_k127_1117975_1 PFAM metallophosphoesterase K06953 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 313.0
SHD3_k127_1117975_2 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000002149 107.0
SHD3_k127_1117975_3 protein conserved in archaea K09746 - - 0.000000000000000000004975 102.0
SHD3_k127_1169551_0 CBS domain containing protein K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 374.0
SHD3_k127_1169551_1 PRC-barrel domain - - - 0.000000000000000000000000000000000000002939 150.0
SHD3_k127_1169551_2 Cation transport regulator K06197 - - 0.0000000000000002373 79.0
SHD3_k127_1170524_0 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 4.576e-197 623.0
SHD3_k127_1170524_1 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000002129 137.0
SHD3_k127_1170524_2 PFAM SOUL heme-binding protein - - - 0.000000000000000000000000001369 114.0
SHD3_k127_1176058_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001129 283.0
SHD3_k127_1176058_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003441 278.0
SHD3_k127_1176058_2 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007059 242.0
SHD3_k127_1176058_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000007892 241.0
SHD3_k127_1176058_5 COG2041 Sulfite oxidase and related enzymes K02016 - - 0.00000000000000000000000000000000001184 143.0
SHD3_k127_1176058_6 PFAM Pyridoxamine 5'-phosphate - - - 0.00000000000000000000621 99.0
SHD3_k127_1179954_0 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002886 513.0
SHD3_k127_1179954_1 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 377.0
SHD3_k127_1179954_2 PFAM Conserved TM helix repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002134 246.0
SHD3_k127_1179954_3 beta-lactamase domain protein - - - 0.000000000002678 70.0
SHD3_k127_1204888_0 COG2133 Glucose sorbosone dehydrogenases - - - 1.435e-253 816.0
SHD3_k127_1204888_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 381.0
SHD3_k127_1204888_2 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000003865 241.0
SHD3_k127_1204888_3 Rubrerythrin K22405 - 1.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000004953 237.0
SHD3_k127_1204888_4 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000001959 207.0
SHD3_k127_1204888_5 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000006005 153.0
SHD3_k127_1204888_6 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000001664 134.0
SHD3_k127_1204888_7 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.000000000000000000004927 108.0
SHD3_k127_1208633_0 Conserved region in glutamate synthase - - - 2.3e-237 737.0
SHD3_k127_1208633_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 460.0
SHD3_k127_1208633_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000499 129.0
SHD3_k127_1260935_1 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000004988 136.0
SHD3_k127_1260935_2 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000001244 57.0
SHD3_k127_1313854_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008392 391.0
SHD3_k127_1313854_1 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 347.0
SHD3_k127_1313854_2 Domain of unknown function (DUF1890) - - - 0.000000000000000000000000000000000000000000000000000000000002884 213.0
SHD3_k127_1313854_3 Domain of unknown function (DUF1894) - - - 0.000000000000000000000000000000000000105 145.0
SHD3_k127_1313854_4 - - - - 0.000000000006334 78.0
SHD3_k127_132072_0 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002033 272.0
SHD3_k127_132072_1 TIGRFAM Por secretion system C-terminal sorting domain - - - 0.0000000000000000000000000000000000000000000000000001555 200.0
SHD3_k127_132072_2 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000001645 68.0
SHD3_k127_1323255_0 Pas domain - - - 2.5e-265 834.0
SHD3_k127_1323255_1 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 332.0
SHD3_k127_1323255_3 - - - - 0.00000004005 59.0
SHD3_k127_1332345_0 PFAM multi antimicrobial extrusion protein MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 571.0
SHD3_k127_1332345_1 glucan 1,4-alpha-glucosidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 366.0
SHD3_k127_1332345_2 Oxidoreductase FAD-binding domain - - - 0.000000000000000000000000000000000000000000000000000004221 200.0
SHD3_k127_1360282_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007263 536.0
SHD3_k127_1360282_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 346.0
SHD3_k127_1360282_2 TIGRFAM PAS sensor protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001813 259.0
SHD3_k127_1360282_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000001578 174.0
SHD3_k127_1360282_4 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000006088 142.0
SHD3_k127_1366013_0 ABC transporter K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 401.0
SHD3_k127_1366013_1 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 318.0
SHD3_k127_1366013_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000354 242.0
SHD3_k127_1366013_3 Bacterial extracellular solute-binding protein K02020 - - 0.000000000000000000000000000000000000000001736 159.0
SHD3_k127_1366013_4 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000001562 161.0
SHD3_k127_1366013_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000003896 109.0
SHD3_k127_1382524_0 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 424.0
SHD3_k127_1382524_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 339.0
SHD3_k127_1382524_2 Flavodoxin domain - - - 0.000000000000000000000000000000000000000000000000001064 188.0
SHD3_k127_1419562_0 PFAM Radical SAM domain protein K07129 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 374.0
SHD3_k127_1419562_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 364.0
SHD3_k127_1419562_2 PFAM Radical SAM domain protein K07129 - - 0.000408 43.0
SHD3_k127_1431076_0 Protein of unknown function (DUF460) K09150 - - 1.624e-232 740.0
SHD3_k127_1431076_1 Rio2, N-terminal K07179 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 315.0
SHD3_k127_1431076_2 PFAM PP-loop domain protein - - - 0.0000000000000002184 83.0
SHD3_k127_1435737_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 524.0
SHD3_k127_1435737_1 Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000001017 218.0
SHD3_k127_1435737_2 parallel beta-helix repeat - - - 0.00000000000000000000000000000000000000000000000002664 187.0
SHD3_k127_1435737_3 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000005628 76.0
SHD3_k127_1448368_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 495.0
SHD3_k127_1448368_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 481.0
SHD3_k127_1448368_10 methyltransferase activity - - - 0.000000000001142 75.0
SHD3_k127_1448368_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 390.0
SHD3_k127_1448368_3 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein K00335,K00390,K18853 - 1.5.99.15,1.6.5.3,1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 372.0
SHD3_k127_1448368_4 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 339.0
SHD3_k127_1448368_5 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 316.0
SHD3_k127_1448368_6 nucleoside 2-deoxyribosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 305.0
SHD3_k127_1448368_7 KH domain protein K06961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001547 253.0
SHD3_k127_1448368_8 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000006093 204.0
SHD3_k127_1448368_9 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000874 196.0
SHD3_k127_1464352_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 509.0
SHD3_k127_1464352_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000151 242.0
SHD3_k127_1464352_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000002548 128.0
SHD3_k127_1464352_4 - - - - 0.00000000329 66.0
SHD3_k127_1466086_0 Ribonuclease R winged-helix domain K09720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 359.0
SHD3_k127_1466086_1 META domain - - - 0.0000003311 63.0
SHD3_k127_1466086_2 META domain K03668 - - 0.00003851 56.0
SHD3_k127_146969_0 PFAM Thiolase K00626 - 2.3.1.9 4.142e-203 667.0
SHD3_k127_146969_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 591.0
SHD3_k127_146969_10 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001231 267.0
SHD3_k127_146969_11 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003745 259.0
SHD3_k127_146969_12 ribosomal protein S15 K02956 - - 0.0000000000000000000000000000000000000000000000000000000000000000001906 233.0
SHD3_k127_146969_13 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.000000000000000000000000000000000000000000000000000000008532 199.0
SHD3_k127_146969_14 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000005519 199.0
SHD3_k127_146969_15 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000007313 164.0
SHD3_k127_146969_16 Zn-ribbon containing protein K07163 - - 0.00000000000000000000000000000000000006389 152.0
SHD3_k127_146969_17 Helix-turn-helix domain - - - 0.00000000000000000000000000000002136 130.0
SHD3_k127_146969_18 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000001163 109.0
SHD3_k127_146969_19 - - - - 0.00002199 52.0
SHD3_k127_146969_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 393.0
SHD3_k127_146969_3 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 373.0
SHD3_k127_146969_4 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 366.0
SHD3_k127_146969_5 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 316.0
SHD3_k127_146969_6 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 324.0
SHD3_k127_146969_7 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 299.0
SHD3_k127_146969_8 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 302.0
SHD3_k127_146969_9 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001375 275.0
SHD3_k127_147260_0 - - - - 0.00000000000000000000000000000000000000000000000008989 181.0
SHD3_k127_147260_1 NifU-like domain - - - 0.000000000000000000000000000007971 119.0
SHD3_k127_147260_2 indolepyruvate ferredoxin oxidoreductase activity K00179,K05524 - 1.2.7.8 0.0000000000000000000000000000805 116.0
SHD3_k127_148325_0 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007314 428.0
SHD3_k127_148325_1 phosphohydrolase (DHH superfamily) K07097 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 389.0
SHD3_k127_148325_10 PFAM Methyltransferase type - - - 0.000003001 59.0
SHD3_k127_148325_2 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 360.0
SHD3_k127_148325_3 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004081 346.0
SHD3_k127_148325_4 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000003602 237.0
SHD3_k127_148325_5 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000000000000000000003476 185.0
SHD3_k127_148325_6 hydrolase K04794 - 3.1.1.29 0.00000000000000000000000000000000000000000000000007719 179.0
SHD3_k127_148325_7 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000000000000000000000009385 139.0
SHD3_k127_148325_8 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000001644 132.0
SHD3_k127_148325_9 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000001396 73.0
SHD3_k127_1485586_0 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.0 1319.0
SHD3_k127_1485586_1 amino acid K03294 - - 2.595e-316 979.0
SHD3_k127_1485586_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 334.0
SHD3_k127_1485586_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000002319 241.0
SHD3_k127_1485586_4 Pas domain - - - 0.000000000000000000000000000000000001388 149.0
SHD3_k127_1493911_0 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 297.0
SHD3_k127_1493911_1 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000004472 247.0
SHD3_k127_1493911_2 N-4 methylation of cytosine K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000000000000006637 246.0
SHD3_k127_1493911_3 Tripartite tricarboxylate transporter TctA family K08971 - - 0.000000000000000000000000000000000000000000000000000000003807 204.0
SHD3_k127_1493911_4 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000002154 207.0
SHD3_k127_1493911_5 transcriptional regulator, XRE family - - - 0.0000000000000000000000000000000000000000000000000001804 190.0
SHD3_k127_1493911_6 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000000000001709 113.0
SHD3_k127_1493911_7 PQ loop repeat K15383 - - 0.0000000008385 72.0
SHD3_k127_1496894_0 PFAM ADP-ribosylation Crystallin J1 K00788,K05521 - 2.5.1.3,3.2.2.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 394.0
SHD3_k127_1496894_1 Belongs to the UPF0305 family K07012 - - 0.00000000000000000000000000000000000000000000000000000000000000001916 229.0
SHD3_k127_1496894_2 CDP-alcohol phosphatidyltransferase K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000001582 124.0
SHD3_k127_1496894_3 CDP-alcohol phosphatidyltransferase K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000005184 76.0
SHD3_k127_1496894_4 PAS domain K00974,K02485 - 2.7.7.72 0.000001096 54.0
SHD3_k127_1511141_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004153 529.0
SHD3_k127_1511141_1 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 348.0
SHD3_k127_1511141_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.00000000000000000000000000000000000000000000000000000000008464 228.0
SHD3_k127_1517509_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 1.39e-235 736.0
SHD3_k127_1517509_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008415 509.0
SHD3_k127_1531859_0 Cysteine desulfurase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 398.0
SHD3_k127_1531859_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 340.0
SHD3_k127_1531859_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 313.0
SHD3_k127_1531859_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000008973 178.0
SHD3_k127_1531859_4 Molybdopterin converting factor K03635 - 2.8.1.12 0.00000000000000000000000000000000001096 141.0
SHD3_k127_1531859_5 Transcriptional regulator K07108 - - 0.000000000000000000000000003264 117.0
SHD3_k127_1531859_6 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000003461 81.0
SHD3_k127_1534160_0 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 3.087e-238 755.0
SHD3_k127_1534160_1 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 367.0
SHD3_k127_1534160_2 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 330.0
SHD3_k127_1534160_3 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000003064 243.0
SHD3_k127_1534160_4 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000001336 186.0
SHD3_k127_1534160_5 PFAM Radical SAM domain protein K06871 - - 0.000000000000000000000000000000000008244 138.0
SHD3_k127_1534160_6 Protein of unknown function (DUF4013) - - - 0.00000000006166 65.0
SHD3_k127_1551493_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 541.0
SHD3_k127_1551493_1 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 424.0
SHD3_k127_1551493_2 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 392.0
SHD3_k127_1551493_3 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007782 385.0
SHD3_k127_1551493_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004864 329.0
SHD3_k127_1551493_5 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 316.0
SHD3_k127_1551493_6 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000003102 202.0
SHD3_k127_1551493_7 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000008392 148.0
SHD3_k127_1556889_0 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000001439 203.0
SHD3_k127_1556889_1 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.00000000000000000000000005832 110.0
SHD3_k127_1556889_2 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000000002687 104.0
SHD3_k127_1591995_0 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 349.0
SHD3_k127_1591995_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.00000000000000000000000000000000002749 136.0
SHD3_k127_1591995_2 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.000000000000000000000000000000004846 131.0
SHD3_k127_1595888_0 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 480.0
SHD3_k127_1595888_1 Alkaline phosphatase homologues K01077 GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564 3.1.3.1 0.000000000003483 73.0
SHD3_k127_1595888_2 Phospholipid methyltransferase - - - 0.00000000002953 72.0
SHD3_k127_1627041_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000003948 245.0
SHD3_k127_1627041_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000353 249.0
SHD3_k127_1627041_2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000004621 172.0
SHD3_k127_1627041_3 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000000000000000000000008604 116.0
SHD3_k127_1627041_4 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.000000000000000000000007295 118.0
SHD3_k127_1627041_5 - - - - 0.000000000000000002822 94.0
SHD3_k127_1627316_0 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006047 287.0
SHD3_k127_1627316_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000001859 224.0
SHD3_k127_1627474_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0032502,GO:0043934,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 415.0
SHD3_k127_1627474_1 SMART zinc finger, CDGSH-type domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 351.0
SHD3_k127_1627474_2 - - - - 0.000000000000000000000000000000000000000000006412 177.0
SHD3_k127_1627474_3 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000003692 150.0
SHD3_k127_1627474_4 SnoaL-like polyketide cyclase - - - 0.000000000000000001026 85.0
SHD3_k127_1638057_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 4.474e-223 700.0
SHD3_k127_1638057_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 475.0
SHD3_k127_1650338_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 552.0
SHD3_k127_1650338_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 349.0
SHD3_k127_1655649_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 2.4e-275 856.0
SHD3_k127_1655649_1 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 5.514e-233 752.0
SHD3_k127_1655649_2 Archaeal Type IV pilin, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006739 604.0
SHD3_k127_1655649_3 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000003259 245.0
SHD3_k127_1655649_4 PFAM BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000000000001197 200.0
SHD3_k127_1655649_5 PFAM ABC transporter K16786 - - 0.000000000000000000000000000000000000000000001677 180.0
SHD3_k127_1655649_6 - K16785 - - 0.0000000000000000000000000000000000199 146.0
SHD3_k127_1655649_7 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.0000000000000000000000000000001403 137.0
SHD3_k127_1655649_8 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000006658 121.0
SHD3_k127_1657809_0 Multicopper K06324 - 1.16.3.3 0.0 1864.0
SHD3_k127_1657809_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009647 434.0
SHD3_k127_1657809_2 Mitochondrial small ribosomal subunit Rsm22 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 341.0
SHD3_k127_1657809_3 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000009432 193.0
SHD3_k127_1657809_4 PFAM PKD domain containing protein - - - 0.000000001114 73.0
SHD3_k127_1696580_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009572 569.0
SHD3_k127_1696580_1 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 419.0
SHD3_k127_1696580_2 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 346.0
SHD3_k127_1696580_3 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000007771 258.0
SHD3_k127_1696580_4 PFAM PRC-barrel domain - - - 0.00000000000000000000000000000000000000004974 153.0
SHD3_k127_1696580_5 - - - - 0.0000000000000000000000000000001972 126.0
SHD3_k127_1698149_0 Involved in regulation of DNA replication K10725 - - 5.404e-197 618.0
SHD3_k127_1698149_1 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000003201 188.0
SHD3_k127_1698149_2 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000000000000000000000000000000000003513 188.0
SHD3_k127_1698149_3 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000000000000000000000000000001137 173.0
SHD3_k127_1702696_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 310.0
SHD3_k127_1702696_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 279.0
SHD3_k127_1702696_2 in RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000000000000005352 205.0
SHD3_k127_1702696_3 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000005571 224.0
SHD3_k127_1715089_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 503.0
SHD3_k127_1715089_1 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 350.0
SHD3_k127_1715089_2 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 320.0
SHD3_k127_1715089_3 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002481 254.0
SHD3_k127_1715089_4 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000000007987 207.0
SHD3_k127_1741829_0 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 587.0
SHD3_k127_1741829_1 PFAM PKD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 351.0
SHD3_k127_1741829_2 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000143 174.0
SHD3_k127_1741829_3 response regulator, receiver K03413,K07662,K07667 - - 0.00000000000000000000000000000000009142 138.0
SHD3_k127_1741829_4 Methyltransferase type 11 - - - 0.00000000000000000002507 94.0
SHD3_k127_1741829_5 - - - - 0.00000000000000003162 86.0
SHD3_k127_1760218_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 2.78e-240 766.0
SHD3_k127_1760218_1 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000006419 212.0
SHD3_k127_1788662_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 3.193e-199 622.0
SHD3_k127_1788662_1 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005185 271.0
SHD3_k127_1788662_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.00000000000000000000000003116 110.0
SHD3_k127_1788662_3 RNA-binding protein involved in rRNA processing K07569 - - 0.000000000000000000000001634 104.0
SHD3_k127_1788662_4 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.000000000002038 68.0
SHD3_k127_1797504_0 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 356.0
SHD3_k127_1797504_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000001357 164.0
SHD3_k127_1798922_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 3.289e-240 749.0
SHD3_k127_1798922_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 566.0
SHD3_k127_1798922_2 Pyruvate kinase, alpha/beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001654 258.0
SHD3_k127_1798922_3 divalent heavy-metal cations transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000001703 214.0
SHD3_k127_1798922_4 Cache domain - - - 0.00000000000000000000000000000000000000000000000000000448 203.0
SHD3_k127_1798922_5 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000002636 164.0
SHD3_k127_18134_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 486.0
SHD3_k127_18134_1 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008122 431.0
SHD3_k127_18134_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 368.0
SHD3_k127_18134_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006199 287.0
SHD3_k127_18134_4 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997 - - 0.0000000000000000000000000000000000000002599 152.0
SHD3_k127_1816440_0 HI0933 family K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 300.0
SHD3_k127_1816440_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009728 281.0
SHD3_k127_1816440_2 Belongs to the UPF0305 family - - - 0.000000000000000000000000000000000000000000000000000000000000000001363 236.0
SHD3_k127_1816440_3 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.0000000000000000002269 95.0
SHD3_k127_1816440_4 - - - - 0.00000000004642 66.0
SHD3_k127_1843793_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 464.0
SHD3_k127_1843793_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 430.0
SHD3_k127_1843793_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 431.0
SHD3_k127_1843793_3 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000008844 202.0
SHD3_k127_1843793_4 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000000000001507 162.0
SHD3_k127_1843793_5 GAF domain protein - - - 0.000000000000000000000000000000127 143.0
SHD3_k127_1843793_6 transcriptional regulators K03724 - - 0.000000000000000000000000008232 111.0
SHD3_k127_1843793_7 Transcriptional regulator K07108 - - 0.0000000000000000001478 94.0
SHD3_k127_1843793_8 nucleic acid binding OB-fold tRNA helicase-type - - - 0.0000000000000001942 83.0
SHD3_k127_1858402_0 PFAM PilT protein domain protein K06865 - - 2.759e-262 821.0
SHD3_k127_1858402_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.775e-237 741.0
SHD3_k127_1858402_2 parallel beta-helix repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 350.0
SHD3_k127_1858402_3 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000002228 228.0
SHD3_k127_1858402_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000000009876 186.0
SHD3_k127_1858402_5 Protein of unknown function (DUF447) K09154 - - 0.0000000000000000000000000000000000000000000000002128 181.0
SHD3_k127_1861623_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 462.0
SHD3_k127_1861623_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 416.0
SHD3_k127_1861623_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000001521 209.0
SHD3_k127_1871158_0 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001958 308.0
SHD3_k127_1884048_0 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 436.0
SHD3_k127_1884048_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007123 265.0
SHD3_k127_1884048_2 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000007375 274.0
SHD3_k127_1884048_3 COG2335 Secreted and surface protein containing fasciclin-like repeats K19519 - - 0.000000000000000000000000000000000008139 153.0
SHD3_k127_1884048_4 COG2335 Secreted and surface protein containing fasciclin-like repeats K19519 - - 0.00000000000000000000000000000000001209 143.0
SHD3_k127_1884048_5 Rhodanese Homology Domain - - - 0.0000000000000000000000000004073 116.0
SHD3_k127_1900842_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 304.0
SHD3_k127_1900842_1 PHP-associated - - - 0.000000000000000003638 89.0
SHD3_k127_1924029_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009148 568.0
SHD3_k127_1924029_1 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 371.0
SHD3_k127_1924029_2 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.00003714 49.0
SHD3_k127_1931895_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 9.361e-198 621.0
SHD3_k127_1931895_1 PFAM membrane-bound metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000002636 228.0
SHD3_k127_1931895_2 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.000000000000000000000000000000000000000000000000000001699 205.0
SHD3_k127_1931895_3 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000004866 162.0
SHD3_k127_1952066_0 - - - - 0.00000000000000000000000000000000000000000000000000007433 196.0
SHD3_k127_1952066_1 Flavodoxin - - - 0.00000000000000000000000000000000000000000481 160.0
SHD3_k127_1952066_2 PFAM alpha beta hydrolase fold - - - 0.00001525 53.0
SHD3_k127_1963386_0 - - - - 0.00000000000000000000000000000000000000000000000000000001026 205.0
SHD3_k127_1963386_1 - - - - 0.000000000003708 74.0
SHD3_k127_1963386_2 - - - - 0.00001663 51.0
SHD3_k127_1980918_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 370.0
SHD3_k127_1980918_1 Belongs to the UPF0215 family K09120 - - 0.000000000000000000000000000000000000000000000000000000003197 219.0
SHD3_k127_1980918_2 membrane-bound metal-dependent hydrolase - - - 0.0000000000000000000000000000000003936 146.0
SHD3_k127_1980918_3 Glycosyl transferase family 21 - - - 0.00000000000000000000003067 112.0
SHD3_k127_1980918_4 - - - - 0.0000000000000000000002408 102.0
SHD3_k127_1980918_5 - - - - 0.000000000000000000001095 101.0
SHD3_k127_2016091_0 AAA domain - - - 1.409e-286 915.0
SHD3_k127_2023418_0 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 576.0
SHD3_k127_2023418_1 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 526.0
SHD3_k127_2023418_10 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000007601 89.0
SHD3_k127_2023418_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000768 482.0
SHD3_k127_2023418_3 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 385.0
SHD3_k127_2023418_4 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007099 330.0
SHD3_k127_2023418_5 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 321.0
SHD3_k127_2023418_6 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 323.0
SHD3_k127_2023418_7 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001265 258.0
SHD3_k127_2023418_8 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000000000000000000000000000000000000000001516 237.0
SHD3_k127_2023418_9 COG0470 ATPase involved in DNA replication K04801 - - 0.000000000000000000000000000000003978 141.0
SHD3_k127_2032282_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 349.0
SHD3_k127_2032282_1 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000543 261.0
SHD3_k127_2032282_2 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007794 248.0
SHD3_k127_2032282_3 binds to the 23S rRNA K02885 - - 0.00000000000000000000000000000000000000000002639 162.0
SHD3_k127_2032282_4 binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000001882 138.0
SHD3_k127_2034925_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008412 443.0
SHD3_k127_2034925_1 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005588 360.0
SHD3_k127_2034925_2 transferase hexapeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000002697 226.0
SHD3_k127_2034925_3 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000002822 224.0
SHD3_k127_2034925_4 Prokaryotic homologs of the JAB domain - - - 0.000000000000000000000000000000000000000000000000000001566 194.0
SHD3_k127_2034925_5 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.00000000000000000000000000000000000000000000001686 190.0
SHD3_k127_2040892_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 474.0
SHD3_k127_2040892_1 PFAM Cysteine-rich small domain K02232,K04720,K05934,K07162,K08260 - 2.1.1.131,3.5.1.90,4.1.1.81,6.3.5.10 0.00000000000000000000000000000000007517 134.0
SHD3_k127_2040892_2 Domain of unknown function (DUF1858) - - - 0.0000000000000000000003812 96.0
SHD3_k127_2052312_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.082e-223 701.0
SHD3_k127_2052312_1 PFAM PUA domain containing protein K07575 - - 0.00000000000000000000000000000000000000000000000000000000000001299 218.0
SHD3_k127_2052312_2 Pfam:DUF552 K09152 - - 0.000000000000000000000000000000000000000000000000000000000005885 213.0
SHD3_k127_2052312_3 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.000000000000000000000000000000000001112 139.0
SHD3_k127_2052312_4 binds to the 23S rRNA K02922 - - 0.00000000000000000000000000003111 117.0
SHD3_k127_2052312_5 Cellulosome anchoring protein cohesin region - - - 0.000000128 60.0
SHD3_k127_206677_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 6.528e-242 752.0
SHD3_k127_206677_1 PFAM glutamine amidotransferase, class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005748 594.0
SHD3_k127_206677_2 Belongs to the glutamate synthase family - - - 0.000000000000000000000000000000000001307 141.0
SHD3_k127_2106222_0 KilA-N - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 332.0
SHD3_k127_2106222_1 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000175 206.0
SHD3_k127_2106222_2 Pas domain - - - 0.00000000000000000000000000000000000000000000000000001119 207.0
SHD3_k127_2106222_3 PFAM Tetratricopeptide repeat - - - 0.00000000001363 73.0
SHD3_k127_2106222_4 Tetratricopeptide repeat - - - 0.0001758 50.0
SHD3_k127_2118285_0 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 511.0
SHD3_k127_2118285_1 Pfam:KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 314.0
SHD3_k127_2121054_0 PFAM Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000001676 162.0
SHD3_k127_2121054_1 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.00000000000000000000000000000000000000002074 170.0
SHD3_k127_2121054_2 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000002732 60.0
SHD3_k127_2121054_3 ABC-type transport system involved in cytochrome c biogenesis permease component K02194 - - 0.00001508 53.0
SHD3_k127_2135849_0 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 505.0
SHD3_k127_2135849_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000002833 186.0
SHD3_k127_2135849_2 PFAM ABC transporter K09013 - - 0.000000002985 57.0
SHD3_k127_2153169_0 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 306.0
SHD3_k127_2153169_1 HPP family - - - 0.00000000000000000000000000002213 124.0
SHD3_k127_2153169_2 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000008364 101.0
SHD3_k127_2153169_3 - - - - 0.00000000002756 68.0
SHD3_k127_2185654_0 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 349.0
SHD3_k127_2185654_1 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009136 345.0
SHD3_k127_2185654_2 LUD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001423 269.0
SHD3_k127_2185654_3 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000002181 246.0
SHD3_k127_2185654_4 - - - - 0.00000000000000000000000000000000005821 137.0
SHD3_k127_2185654_5 - - - - 0.0000038 56.0
SHD3_k127_2186603_0 Glycosyltransferase 36 associated - - - 0.0 1186.0
SHD3_k127_2186603_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000009865 194.0
SHD3_k127_2209993_0 PFAM NADH Ubiquinone plastoquinone (complex I) K14086 - - 8.553e-231 730.0
SHD3_k127_2209993_1 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 561.0
SHD3_k127_2209993_10 Competence protein K06198 - - 0.0005739 51.0
SHD3_k127_2209993_11 PFAM HEPN domain - - - 0.0006436 46.0
SHD3_k127_2209993_2 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 391.0
SHD3_k127_2209993_3 PFAM NADH ubiquinone oxidoreductase, 20 K14088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001816 267.0
SHD3_k127_2209993_4 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000003671 172.0
SHD3_k127_2209993_5 RuvA, C-terminal domain K03550 - 3.6.4.12 0.000000000000000000000000000000000000000002135 162.0
SHD3_k127_2209993_6 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000003068 167.0
SHD3_k127_2209993_7 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) K14091,K15831 - - 0.00000000000000000000000000004846 127.0
SHD3_k127_2209993_8 Rieske 2Fe-2S - - - 0.00000000000000000000005866 102.0
SHD3_k127_2209993_9 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K14089 - - 0.000000000000000000002296 104.0
SHD3_k127_2220820_0 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 385.0
SHD3_k127_2220820_1 KaiB K08481 - - 0.0000000000000000000001784 102.0
SHD3_k127_2220820_2 Matrixin - - - 0.00000000000007646 72.0
SHD3_k127_2220820_3 Hemerythrin - - - 0.0001038 51.0
SHD3_k127_2220820_4 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0002972 50.0
SHD3_k127_2223664_0 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003374 380.0
SHD3_k127_2223664_1 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 321.0
SHD3_k127_2223664_2 PFAM Radical SAM domain protein K06937 - - 0.00000000000000000000000000000000006971 134.0
SHD3_k127_2223664_3 - - - - 0.000000000000000000008504 94.0
SHD3_k127_2234272_0 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002114 276.0
SHD3_k127_2245423_0 PFAM Abortive infection protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003955 265.0
SHD3_k127_2245423_1 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000003749 168.0
SHD3_k127_2245423_2 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000005831 143.0
SHD3_k127_2245423_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000004891 143.0
SHD3_k127_2245423_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000001995 58.0
SHD3_k127_2253761_0 metallopeptidase activity K20276 - - 0.000000000000000000000000000000000000000000000003738 194.0
SHD3_k127_2253761_1 PFAM PKD domain containing protein - - - 0.0000000000000000000000000001714 132.0
SHD3_k127_2261684_0 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 306.0
SHD3_k127_2261684_1 sensor histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005096 297.0
SHD3_k127_2261684_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000004619 98.0
SHD3_k127_2264091_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 477.0
SHD3_k127_2264091_1 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000003835 165.0
SHD3_k127_2264091_2 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016272,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032991,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000008471 162.0
SHD3_k127_2264091_3 PFAM Ribosomal LX protein K02944 - - 0.00000000000003016 79.0
SHD3_k127_2276464_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 3.457e-296 920.0
SHD3_k127_2276464_1 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.000000000000000000000000000000000000000002669 160.0
SHD3_k127_2276464_2 - - - - 0.000000000000000000000000000000000000001275 155.0
SHD3_k127_2310103_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 420.0
SHD3_k127_2310103_1 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 350.0
SHD3_k127_2312324_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008912 583.0
SHD3_k127_2312324_1 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008538 501.0
SHD3_k127_2312324_10 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.00000000000000000000000000000000000000000000000000000004001 198.0
SHD3_k127_2312324_11 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000004045 168.0
SHD3_k127_2312324_12 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000002396 149.0
SHD3_k127_2312324_13 SpoVT / AbrB like domain - - - 0.00000000000000000000000000000006349 127.0
SHD3_k127_2312324_14 - - - - 0.000000000000000006624 85.0
SHD3_k127_2312324_15 Protein of unknown function (DUF447) K09154 - - 0.000000000000000009251 91.0
SHD3_k127_2312324_16 - - - - 0.00000000000001656 77.0
SHD3_k127_2312324_2 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 496.0
SHD3_k127_2312324_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 487.0
SHD3_k127_2312324_4 CO dehydrogenase/acetyl-CoA synthase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 486.0
SHD3_k127_2312324_5 Catalyzes the reversible phosphorylation of UMP to UDP K00947 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 377.0
SHD3_k127_2312324_6 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 334.0
SHD3_k127_2312324_7 Molybdate transporter of MFS superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 331.0
SHD3_k127_2312324_8 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008922 307.0
SHD3_k127_2312324_9 Uncharacterised protein family UPF0066 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001752 237.0
SHD3_k127_2332677_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 494.0
SHD3_k127_2332677_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 432.0
SHD3_k127_2332677_2 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 404.0
SHD3_k127_2332677_3 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 405.0
SHD3_k127_2332677_4 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 295.0
SHD3_k127_2332677_5 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001137 286.0
SHD3_k127_2332677_6 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000001311 259.0
SHD3_k127_2332677_7 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.0000000001283 66.0
SHD3_k127_2332677_8 KTSC domain - - - 0.0000002728 63.0
SHD3_k127_2340454_0 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009993 323.0
SHD3_k127_2340454_1 endonuclease III K03575 - - 0.0000000000000000000000000000000000000001699 162.0
SHD3_k127_2350827_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.795e-259 809.0
SHD3_k127_2350827_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 356.0
SHD3_k127_2350827_2 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002286 281.0
SHD3_k127_2350827_3 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000581 239.0
SHD3_k127_2350827_4 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000007623 199.0
SHD3_k127_2350827_5 binds to the 23S rRNA K02876 - - 0.000000000000000001058 87.0
SHD3_k127_236739_0 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 1.47e-199 634.0
SHD3_k127_236739_1 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 446.0
SHD3_k127_237645_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.022e-227 722.0
SHD3_k127_237645_1 type II secretion system protein K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 459.0
SHD3_k127_237645_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 387.0
SHD3_k127_237645_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000000000000000000000000000000007278 199.0
SHD3_k127_237645_4 - - - - 0.00000000000000000000000000000000000000000000005164 173.0
SHD3_k127_237645_5 H subunit K02107 - - 0.00000000000000000000000000000001312 130.0
SHD3_k127_237645_6 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000000000000000004743 126.0
SHD3_k127_237645_7 - - - - 0.000000000000002603 78.0
SHD3_k127_237645_8 type II secretion system protein K07333 - - 0.000000000000004049 78.0
SHD3_k127_2379342_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 479.0
SHD3_k127_2379342_1 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 443.0
SHD3_k127_2379342_2 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.0000000000000000000000000004406 118.0
SHD3_k127_2379342_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.000000000006914 69.0
SHD3_k127_2379342_4 - - - - 0.000006919 55.0
SHD3_k127_2391158_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 4.845e-300 943.0
SHD3_k127_2391158_1 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000000000003322 248.0
SHD3_k127_2391158_2 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000134 210.0
SHD3_k127_2391158_3 - - - - 0.000000000000000000000000000000726 125.0
SHD3_k127_2391158_4 - - - - 0.0000000000000000000000000000929 123.0
SHD3_k127_2391158_6 LysM domain - - - 0.00000000000000000004235 94.0
SHD3_k127_2391158_7 alpha/beta hydrolase fold - - - 0.000000000000001089 78.0
SHD3_k127_2407408_0 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 351.0
SHD3_k127_2407408_1 SMART Elongator protein 3 MiaB NifB K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 323.0
SHD3_k127_2407408_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 290.0
SHD3_k127_2407408_3 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000001651 223.0
SHD3_k127_2407408_4 SMART regulatory protein AsnC Lrp family K22225 - - 0.0000000000000000000000000000000000000217 156.0
SHD3_k127_2407408_5 transcriptional regulator, AsnC family - - - 0.000000000000000003099 89.0
SHD3_k127_2407408_6 Uncharacterized conserved protein (DUF2196) - - - 0.0000000000005315 82.0
SHD3_k127_2407408_7 PBS lyase HEAT-like repeat - - - 0.0000008413 57.0
SHD3_k127_2408906_0 PFAM Alcohol dehydrogenase zinc-binding domain protein K00002 - 1.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 591.0
SHD3_k127_2408906_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 377.0
SHD3_k127_2408906_2 Belongs to the peptidase S8 family - - - 0.00000000000000006344 92.0
SHD3_k127_2408906_3 Control of competence regulator ComK, YlbF/YmcA - - - 0.000000000001276 76.0
SHD3_k127_2412153_0 PFAM formate nitrite transporter K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 466.0
SHD3_k127_2412153_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.00000000000000000000000000000000000000000000000000000000000004384 217.0
SHD3_k127_2426476_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 3.856e-291 903.0
SHD3_k127_2426476_1 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 324.0
SHD3_k127_2426476_2 PFAM ribosomal protein S8E K02995 - - 0.000000000000000000000000000000000000000000000000000000000005689 209.0
SHD3_k127_2426476_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000000000005123 201.0
SHD3_k127_2426476_4 protein conserved in archaea - - - 0.000000000000000000000000000000000000004718 154.0
SHD3_k127_2456055_0 Belongs to the peptidase M24B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 533.0
SHD3_k127_2456055_1 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 440.0
SHD3_k127_2456055_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000000000000000000000000000000001974 225.0
SHD3_k127_2456055_3 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000007542 192.0
SHD3_k127_2456055_4 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.00000000000000000000000000001286 118.0
SHD3_k127_246995_0 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000007683 218.0
SHD3_k127_247084_0 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 485.0
SHD3_k127_247084_1 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000002613 213.0
SHD3_k127_247084_2 iron dependent repressor K03709 - - 0.0000000000000000000000000000000001097 142.0
SHD3_k127_247084_3 ATPases associated with a variety of cellular activities K02006 - - 0.00000000000004364 83.0
SHD3_k127_2488742_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.0 1132.0
SHD3_k127_2488742_1 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 440.0
SHD3_k127_2488742_2 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 353.0
SHD3_k127_2488742_3 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000211 170.0
SHD3_k127_2488742_4 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07006 - - 0.000000000000000000000000000000000002728 139.0
SHD3_k127_2488742_5 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000001273 140.0
SHD3_k127_2491977_0 PFAM NAD dependent epimerase dehydratase family K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 405.0
SHD3_k127_2491977_1 PFAM Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000268 253.0
SHD3_k127_2491977_2 NmrA-like family - - - 0.0000166 52.0
SHD3_k127_2496603_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1501.0
SHD3_k127_2496603_1 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000001047 162.0
SHD3_k127_2496603_2 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000002468 124.0
SHD3_k127_2522645_0 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000004687 205.0
SHD3_k127_2522645_1 membrane protein (DUF2078) K08982 - - 0.0000000000000000000000000000000005312 134.0
SHD3_k127_252747_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 435.0
SHD3_k127_252747_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008002 343.0
SHD3_k127_252747_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000002393 207.0
SHD3_k127_252747_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215,K03546 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 0.000000000000000000000000000000000000000000000007746 184.0
SHD3_k127_252747_4 Domain of unknown function (DUF3821) - - - 0.000000000000000000000004983 107.0
SHD3_k127_252747_5 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000003354 97.0
SHD3_k127_252747_6 structural constituent of ribosome K02962 - - 0.0000000000000000000005337 96.0
SHD3_k127_252747_7 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000004711 92.0
SHD3_k127_252747_8 Transcriptional regulator K21219,K21220 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000166 83.0
SHD3_k127_2540747_0 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 357.0
SHD3_k127_2540747_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000006021 211.0
SHD3_k127_2540747_2 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000245 169.0
SHD3_k127_2540747_3 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000000000001348 158.0
SHD3_k127_2540747_4 Sugar (and other) transporter - - - 0.00000000000000000000000005787 111.0
SHD3_k127_2557467_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 2.417e-227 711.0
SHD3_k127_2557467_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000778 481.0
SHD3_k127_2557467_2 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009248 435.0
SHD3_k127_2557467_3 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 296.0
SHD3_k127_2557467_4 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000003492 133.0
SHD3_k127_2557467_5 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.0000000001098 72.0
SHD3_k127_2582359_0 Protein-export membrane protein SecD K03072 - - 1.647e-215 689.0
SHD3_k127_2582359_1 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 382.0
SHD3_k127_2582359_2 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000558 165.0
SHD3_k127_2582359_3 Protein of unknown function (DUF2551) - - - 0.000000000000000000000000000000002754 133.0
SHD3_k127_2582359_4 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000005745 126.0
SHD3_k127_2582359_5 - - - - 0.000000000000000000000005637 104.0
SHD3_k127_2593425_0 PFAM Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 488.0
SHD3_k127_2593425_1 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 300.0
SHD3_k127_2595332_0 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 499.0
SHD3_k127_2595332_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 479.0
SHD3_k127_2595332_2 PFAM TatD-related deoxyribonuclease K07049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000697 347.0
SHD3_k127_2595332_3 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 330.0
SHD3_k127_2595332_4 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004004 299.0
SHD3_k127_2595332_5 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000001498 162.0
SHD3_k127_2595332_6 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000000007608 138.0
SHD3_k127_2595332_7 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000001578 115.0
SHD3_k127_2596709_0 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 622.0
SHD3_k127_2596709_1 ABC-type tungstate transport system, periplasmic component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002191 259.0
SHD3_k127_2613212_0 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004002 248.0
SHD3_k127_2627730_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 334.0
SHD3_k127_2627730_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001383 290.0
SHD3_k127_2627730_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001673 274.0
SHD3_k127_2627730_3 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000009324 87.0
SHD3_k127_2640691_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007861 339.0
SHD3_k127_2640691_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 298.0
SHD3_k127_2640691_2 COG1881 Phospholipid-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000313 183.0
SHD3_k127_2640691_3 Elongator protein 3 MiaB NifB - - - 0.00005188 48.0
SHD3_k127_2651569_0 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009442 311.0
SHD3_k127_2651569_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000004782 241.0
SHD3_k127_2651591_0 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 2.578e-226 712.0
SHD3_k127_2651591_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000002571 248.0
SHD3_k127_2661201_0 - - - - 0.00000000000000000000000000000000000000000000000000000000008619 227.0
SHD3_k127_2661201_1 PFAM HEPN domain - - - 0.0000000000000000000000000000000000004967 145.0
SHD3_k127_2661201_2 PQQ-like domain - - - 0.0000000000000000000000000142 126.0
SHD3_k127_2666642_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000001392 227.0
SHD3_k127_2666642_1 sequence-specific DNA binding K03719 - - 0.00000000000000000000000000000000000000000000002974 174.0
SHD3_k127_2684773_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 3.925e-260 805.0
SHD3_k127_2684773_1 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 607.0
SHD3_k127_2684773_10 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000002602 145.0
SHD3_k127_2684773_11 - - - - 0.0000000000000000000000000000000824 126.0
SHD3_k127_2684773_12 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0006143 51.0
SHD3_k127_2684773_2 TIGRFAM TraB family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 503.0
SHD3_k127_2684773_3 Belongs to the UPF0284 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 384.0
SHD3_k127_2684773_4 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009903 387.0
SHD3_k127_2684773_5 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002584 276.0
SHD3_k127_2684773_6 MarC family integral membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001507 266.0
SHD3_k127_2684773_7 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000000000002257 258.0
SHD3_k127_2684773_8 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000005553 201.0
SHD3_k127_2684773_9 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000006011 199.0
SHD3_k127_26916_0 Aldo/keto reductase family K07079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 466.0
SHD3_k127_26916_1 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000000000000000003951 170.0
SHD3_k127_2740649_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000001952 223.0
SHD3_k127_2740649_1 DSBA-like thioredoxin domain - - - 0.000000000000000002733 85.0
SHD3_k127_2742167_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001132 250.0
SHD3_k127_2742167_1 PFAM peptidase zinc-dependent K06974 - - 0.000000000000000000000000000000000000000000000000000000002044 211.0
SHD3_k127_2742167_2 Belongs to the UPF0146 family K09713 - - 0.0000000000000000000000000000002672 135.0
SHD3_k127_2742167_3 - - - - 0.0000005668 61.0
SHD3_k127_2742167_4 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.0001081 48.0
SHD3_k127_2782418_0 ATP-binding region, ATPase domain protein K03413,K07662,K07667 - - 7.493e-205 647.0
SHD3_k127_2782418_1 membrane-associated protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001762 247.0
SHD3_k127_2782418_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000000000008101 205.0
SHD3_k127_2782418_3 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000002554 148.0
SHD3_k127_2794473_0 Voltage gated chloride channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 386.0
SHD3_k127_2794473_1 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000458 162.0
SHD3_k127_2794473_2 Membrane transport protein K07088 - - 0.000000000000000000000000000000000002948 149.0
SHD3_k127_2794473_3 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000307 117.0
SHD3_k127_2794473_4 LURP-one-related - - - 0.00000000000000000000003896 110.0
SHD3_k127_2794473_5 LURP-one-related - - - 0.00000000000000000001123 94.0
SHD3_k127_2794473_6 Glutaredoxin - - - 0.0000004367 57.0
SHD3_k127_2794473_7 LURP-one-related - - - 0.000005122 53.0
SHD3_k127_2797929_0 SMART Elongator protein 3 MiaB NifB - - - 3.16e-258 808.0
SHD3_k127_2797929_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 536.0
SHD3_k127_2797929_2 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 410.0
SHD3_k127_2797929_3 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000873 336.0
SHD3_k127_2797929_4 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 289.0
SHD3_k127_2797929_5 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001666 284.0
SHD3_k127_2797929_6 Amino acid ABC transporter substrate-binding protein, PAAT family K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008474 278.0
SHD3_k127_2797929_7 archaeosine synthase activity K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000001644 255.0
SHD3_k127_2797929_8 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000000000000000000000000000000000000000001049 209.0
SHD3_k127_2797929_9 COG0237 Dephospho-CoA kinase - - - 0.000000000000000000000000003677 121.0
SHD3_k127_2824935_0 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 313.0
SHD3_k127_2824935_1 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000001358 202.0
SHD3_k127_2824935_2 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000001611 175.0
SHD3_k127_2824935_3 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000002181 158.0
SHD3_k127_2841284_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 1.281e-264 822.0
SHD3_k127_2841284_1 coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002842 254.0
SHD3_k127_2841284_2 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.00000001392 55.0
SHD3_k127_2841284_3 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.00002133 50.0
SHD3_k127_2848679_0 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 580.0
SHD3_k127_2848679_1 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 320.0
SHD3_k127_2848679_2 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000003216 248.0
SHD3_k127_2848679_3 Oxidoreductase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000004212 220.0
SHD3_k127_2848679_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000000000000001629 119.0
SHD3_k127_2848679_5 - - - - 0.00000000001657 72.0
SHD3_k127_2881184_0 Transport of potassium into the cell K03549 - - 2.21e-256 803.0
SHD3_k127_2881228_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 4.066e-195 614.0
SHD3_k127_2881228_1 parallel beta-helix repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 358.0
SHD3_k127_2881228_2 FeS cluster assembly scaffold protein NifU K04488 - - 0.00000000000000000000000000000000000000000000000000000000008357 211.0
SHD3_k127_2897036_0 CBS domain containing protein K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 471.0
SHD3_k127_2897036_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 319.0
SHD3_k127_2897036_10 PhoQ Sensor - - - 0.0000000000000000000000005491 108.0
SHD3_k127_2897036_11 PFAM Pyridoxamine 5'-phosphate oxidase-related K07005 - - 0.00000000000000000000162 104.0
SHD3_k127_2897036_12 Protein of unknown function (DUF2769) - - - 0.000000000000000001618 88.0
SHD3_k127_2897036_13 - - - - 0.00000000000005212 79.0
SHD3_k127_2897036_14 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000003336 70.0
SHD3_k127_2897036_15 - K03686 - - 0.00000000000306 72.0
SHD3_k127_2897036_2 Protein of unknown function (DUF4013) - - - 0.000000000000000000000000000000000000000000000000000000000002343 215.0
SHD3_k127_2897036_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000009016 207.0
SHD3_k127_2897036_4 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000001616 197.0
SHD3_k127_2897036_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03471 - 3.1.26.4 0.000000000000000000000000000000000000000000000001244 186.0
SHD3_k127_2897036_6 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000002777 185.0
SHD3_k127_2897036_7 PRC-barrel domain - - - 0.00000000000000000000000000000000000001143 148.0
SHD3_k127_2897036_8 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000001449 151.0
SHD3_k127_2897036_9 ChaB K06197 - - 0.0000000000000000000000000014 116.0
SHD3_k127_2912684_0 Disaggregatase related - - - 0.0000000000000000000000000000000000000000000000001458 194.0
SHD3_k127_2912684_1 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000000000000001817 108.0
SHD3_k127_2912684_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000003386 59.0
SHD3_k127_2937137_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K02474 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 597.0
SHD3_k127_2937137_1 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004851 274.0
SHD3_k127_2937137_2 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000004456 271.0
SHD3_k127_2937137_3 COG1202 Superfamily II helicase, archaea-specific - - - 0.0000000000000000000000000000000000000000000000000000009509 203.0
SHD3_k127_2966914_0 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000007487 171.0
SHD3_k127_2966914_1 Peptidase A4 family - - - 0.000000000000000000000000000000000003615 150.0
SHD3_k127_2966914_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000001172 63.0
SHD3_k127_2987777_0 L-lactate permease K03303 - - 8.857e-238 744.0
SHD3_k127_2987777_1 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 599.0
SHD3_k127_2987777_2 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000001947 184.0
SHD3_k127_2987777_3 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.000000000000000000000000000000000000000001803 160.0
SHD3_k127_2987777_4 redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000000000001804 138.0
SHD3_k127_2987777_5 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000000000001559 128.0
SHD3_k127_2987777_6 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000000000000002477 111.0
SHD3_k127_2987777_7 Protein of unknown function (DUF1232) - - - 0.000000000000002559 85.0
SHD3_k127_2987777_8 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000006798 72.0
SHD3_k127_2989842_0 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 384.0
SHD3_k127_2989842_1 Pfam:KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 335.0
SHD3_k127_2989842_2 PFAM TspO MBR family K05770 - - 0.0000000000000000000000000000000000000000001829 164.0
SHD3_k127_2989842_3 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000004179 108.0
SHD3_k127_2989842_4 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000009833 96.0
SHD3_k127_2989842_5 SigmaK-factor processing regulatory protein BofA K06317 - - 0.0000000000000003276 84.0
SHD3_k127_2989842_6 SigmaK-factor processing regulatory protein BofA - - - 0.000000002413 61.0
SHD3_k127_2992523_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 467.0
SHD3_k127_2992523_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 382.0
SHD3_k127_2992523_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000008993 217.0
SHD3_k127_3018251_0 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 460.0
SHD3_k127_3018251_1 Subtilase family K14645 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003613 361.0
SHD3_k127_3022856_0 peptidyl-tyrosine sulfation - - - 0.0 1425.0
SHD3_k127_3022856_1 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 3.009e-221 691.0
SHD3_k127_3022856_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 465.0
SHD3_k127_3022856_3 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000000005533 121.0
SHD3_k127_3034317_0 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 516.0
SHD3_k127_3034317_1 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 494.0
SHD3_k127_3034317_2 tRNAHis guanylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002297 265.0
SHD3_k127_3034317_3 PFAM PRC-barrel domain - - - 0.0000000000000000000000000000000000006375 143.0
SHD3_k127_3038170_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 3.624e-236 736.0
SHD3_k127_3038170_1 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.0000000000000000000000000000000000000000000000000000004836 197.0
SHD3_k127_3049589_0 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 580.0
SHD3_k127_3049589_1 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 538.0
SHD3_k127_3049589_10 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000000000001349 115.0
SHD3_k127_3049589_11 Involved in cell shape control K22222 - - 0.0006343 43.0
SHD3_k127_3049589_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 346.0
SHD3_k127_3049589_3 UbiA prenyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 311.0
SHD3_k127_3049589_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005532 285.0
SHD3_k127_3049589_5 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000006985 253.0
SHD3_k127_3049589_6 PHP-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000714 229.0
SHD3_k127_3049589_7 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000002771 183.0
SHD3_k127_3049589_8 PFAM Alkaline phosphatase K01077 - 3.1.3.1 0.00000000000000000000000000000000000004246 151.0
SHD3_k127_3049589_9 - - - - 0.0000000000000000000000000006753 120.0
SHD3_k127_3090102_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 3.803e-260 807.0
SHD3_k127_3090102_1 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 1.442e-239 745.0
SHD3_k127_3090102_10 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.0000000000000000007672 87.0
SHD3_k127_3090102_11 - - - - 0.000000000000006968 78.0
SHD3_k127_3090102_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.566e-236 745.0
SHD3_k127_3090102_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 608.0
SHD3_k127_3090102_4 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 453.0
SHD3_k127_3090102_5 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 432.0
SHD3_k127_3090102_6 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 401.0
SHD3_k127_3090102_7 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008566 355.0
SHD3_k127_3090102_8 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 355.0
SHD3_k127_3090102_9 Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000004907 174.0
SHD3_k127_3095224_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 410.0
SHD3_k127_3095224_1 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 396.0
SHD3_k127_3095224_2 PFAM ABC transporter related K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 309.0
SHD3_k127_3095224_3 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000001006 112.0
SHD3_k127_3095224_4 - - - - 0.0000000000000000000000007634 107.0
SHD3_k127_3095224_5 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000001736 94.0
SHD3_k127_3095224_6 Psort location Periplasmic, score K09807 - - 0.000000000000001616 86.0
SHD3_k127_3095224_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000002727 76.0
SHD3_k127_3109683_0 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 414.0
SHD3_k127_3109683_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000005741 217.0
SHD3_k127_3109683_2 membrane-bound metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000001014 159.0
SHD3_k127_3109683_3 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000000000001211 123.0
SHD3_k127_3109683_4 DEAD DEAH box helicase K03724 - - 0.00000000000000000002297 100.0
SHD3_k127_3109683_5 PFAM PKD domain containing protein - - - 0.00000000000000002677 92.0
SHD3_k127_3109683_6 Belongs to the peptidase M48B family K03799 - - 0.00000006605 54.0
SHD3_k127_3122504_0 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 467.0
SHD3_k127_3122504_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004184 289.0
SHD3_k127_3122504_2 membrane-associated protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000004205 229.0
SHD3_k127_3131213_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 323.0
SHD3_k127_3131213_1 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006126 266.0
SHD3_k127_3131213_2 LURP-one-related - - - 0.000000000000000000000000000000000000000000000000000000000000000009171 229.0
SHD3_k127_3131213_3 Permease - - - 0.0000000000000000000000000000000002725 149.0
SHD3_k127_3131213_4 - - - - 0.0004482 48.0
SHD3_k127_3154409_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 3.783e-312 970.0
SHD3_k127_3154409_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000007267 119.0
SHD3_k127_3155177_0 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002207 431.0
SHD3_k127_3155177_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000008808 243.0
SHD3_k127_3173231_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.0 1095.0
SHD3_k127_3173231_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 8.219e-299 921.0
SHD3_k127_3173231_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 - 2.7.7.6 0.0000000000000000000000000000000001123 134.0
SHD3_k127_3193280_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 585.0
SHD3_k127_3193280_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000001653 232.0
SHD3_k127_3193280_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000006772 242.0
SHD3_k127_3193280_3 SigmaK-factor processing regulatory protein BofA K06317 - - 0.000000000000000001547 87.0
SHD3_k127_3206129_0 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 356.0
SHD3_k127_3206129_1 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000009389 208.0
SHD3_k127_3206129_2 Major Facilitator Superfamily - - - 0.000000000000000000000000000000001764 135.0
SHD3_k127_3248531_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 5.182e-241 752.0
SHD3_k127_3248531_1 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 578.0
SHD3_k127_3248531_2 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 425.0
SHD3_k127_3248531_3 - - - - 0.00000000000000000000000000000000000000000000000000000004009 204.0
SHD3_k127_3251982_0 Domain of unknown function (DUF814) - - - 1.028e-226 719.0
SHD3_k127_3251982_1 in RNase L inhibitor, RLI K06174 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 554.0
SHD3_k127_3251982_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 416.0
SHD3_k127_3251982_3 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 301.0
SHD3_k127_3251982_4 RNase L inhibitor, RLI - - - 0.000000000000000000000000000000000001504 141.0
SHD3_k127_3259279_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 3.111e-224 707.0
SHD3_k127_3259279_1 Pfam:KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 366.0
SHD3_k127_3259279_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000000000000000000000000000000468 193.0
SHD3_k127_3259279_3 COG1002 Type II restriction enzyme, methylase subunits - - - 0.000000000000000003252 100.0
SHD3_k127_3259356_0 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 372.0
SHD3_k127_3259356_1 electron transfer activity - - - 0.0000000000000000001589 88.0
SHD3_k127_3267979_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000002358 191.0
SHD3_k127_3300265_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 499.0
SHD3_k127_3300265_1 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 459.0
SHD3_k127_3300265_2 - - - - 0.000000000000006501 83.0
SHD3_k127_3302288_0 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 535.0
SHD3_k127_3302288_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001556 226.0
SHD3_k127_3302288_2 Alkaline phosphatase homologues K01077 GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564 3.1.3.1 0.0000000000000000000000000000000000000000000000000000009675 213.0
SHD3_k127_3302288_3 PFAM PKD domain containing protein - - - 0.00000000000000003333 96.0
SHD3_k127_3305772_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 572.0
SHD3_k127_3305772_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 340.0
SHD3_k127_3305772_2 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 289.0
SHD3_k127_3305772_3 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000000000000000000001522 204.0
SHD3_k127_3305772_4 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000001184 163.0
SHD3_k127_332761_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.278e-253 805.0
SHD3_k127_332761_1 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000004542 261.0
SHD3_k127_3344704_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1235.0
SHD3_k127_3344704_1 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000006982 76.0
SHD3_k127_3382319_0 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 606.0
SHD3_k127_3382319_1 PFAM ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 539.0
SHD3_k127_3382319_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007179 311.0
SHD3_k127_3382319_3 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000001745 234.0
SHD3_k127_3382319_4 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000445 229.0
SHD3_k127_3382319_5 NMT1-like family K02051 - - 0.00000000000000000000000000000000000005581 155.0
SHD3_k127_3401171_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 5.107e-239 745.0
SHD3_k127_3401171_1 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 445.0
SHD3_k127_3401171_2 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 379.0
SHD3_k127_3401171_3 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 306.0
SHD3_k127_3401171_4 parallel beta-helix repeat - - - 0.0000000000000000000000000000000000000000000000355 184.0
SHD3_k127_3401171_5 PFAM ABC transporter related K01990,K09695 - - 0.00000000000000000000000000000000000000001383 158.0
SHD3_k127_3418118_0 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000266 234.0
SHD3_k127_3418118_1 Protein of unknown function (DUF998) - - - 0.0000000000000000000000000000000000000000000003221 179.0
SHD3_k127_3418118_2 ATP cone domain - - - 0.000000000000000000797 90.0
SHD3_k127_3418118_3 - - - - 0.00000004624 58.0
SHD3_k127_3418118_4 MASE1 - - - 0.0002081 53.0
SHD3_k127_347065_0 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 464.0
SHD3_k127_347065_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 342.0
SHD3_k127_347065_2 KH, type 1, domain K07041 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 310.0
SHD3_k127_347065_3 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000000004977 213.0
SHD3_k127_347065_4 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000001149 151.0
SHD3_k127_3471872_0 CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 530.0
SHD3_k127_3471872_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 315.0
SHD3_k127_347591_0 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 441.0
SHD3_k127_347591_1 Ribonuclease R winged-helix domain K09720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 351.0
SHD3_k127_347591_2 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 343.0
SHD3_k127_347591_3 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000001765 168.0
SHD3_k127_3506381_0 Uncharacterized membrane protein (DUF2298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 407.0
SHD3_k127_3506381_1 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 383.0
SHD3_k127_3506381_2 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 373.0
SHD3_k127_3506381_3 PFAM Glycosyl transferase family 2 K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 313.0
SHD3_k127_3534532_0 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 435.0
SHD3_k127_3534532_1 PFAM PKD domain containing protein - - - 0.00000000000000000000001316 114.0
SHD3_k127_3546943_0 PFAM oxidoreductase domain protein - - - 0.000000000000000000000000009076 120.0
SHD3_k127_3546943_1 PFAM Radical SAM K06871 - - 0.000000000000000000001968 102.0
SHD3_k127_3565239_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 296.0
SHD3_k127_3565239_1 Catalase K03781 - 1.11.1.6 0.0000000000000000000000000000000000002034 147.0
SHD3_k127_3565239_2 Acyltransferase - - - 0.000000000000001267 79.0
SHD3_k127_3565239_3 - - - - 0.0000000007867 67.0
SHD3_k127_3589036_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 1.105e-210 661.0
SHD3_k127_3589036_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 409.0
SHD3_k127_3589036_2 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000008077 241.0
SHD3_k127_3589036_3 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000000000000000004776 109.0
SHD3_k127_3589036_4 - - - - 0.00000000002762 76.0
SHD3_k127_3602354_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 4.885e-215 673.0
SHD3_k127_3602354_1 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000000000000000002864 183.0
SHD3_k127_3602354_2 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000006428 108.0
SHD3_k127_3613125_0 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000005555 249.0
SHD3_k127_3613125_1 PFAM Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000000000000000000000001716 190.0
SHD3_k127_3613125_2 YCII-related domain - - - 0.00000000000000000005439 93.0
SHD3_k127_3613125_3 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000007411 66.0
SHD3_k127_3616859_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 373.0
SHD3_k127_3616859_1 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006216 338.0
SHD3_k127_3616859_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000002574 273.0
SHD3_k127_3616859_3 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002338 281.0
SHD3_k127_3616859_4 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000006622 194.0
SHD3_k127_3616859_5 PBS lyase HEAT-like repeat - - - 0.0000004448 60.0
SHD3_k127_3629717_0 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 424.0
SHD3_k127_3629717_1 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009049 370.0
SHD3_k127_3629717_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006787 285.0
SHD3_k127_3629717_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004972 265.0
SHD3_k127_3629717_4 membrane - - - 0.00000000000000000000000000000000000000000009349 171.0
SHD3_k127_3637347_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 604.0
SHD3_k127_3637347_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 385.0
SHD3_k127_3637347_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000003384 250.0
SHD3_k127_3637347_3 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000009374 68.0
SHD3_k127_367997_0 Protease prsW family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003809 261.0
SHD3_k127_367997_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000003063 173.0
SHD3_k127_367997_2 - - - - 0.000000000000000000003854 102.0
SHD3_k127_3685540_0 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 603.0
SHD3_k127_3685540_1 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 330.0
SHD3_k127_3685540_2 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001008 272.0
SHD3_k127_3685540_3 Involved in protein export. The function of the beta subunit is - GO:0003674,GO:0005085,GO:0005086,GO:0005488,GO:0005515,GO:0008150,GO:0019899,GO:0051020,GO:0065007,GO:0065009,GO:0098772 - 0.000000000000003561 76.0
SHD3_k127_3716242_0 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000004197 207.0
SHD3_k127_3716242_1 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000002846 172.0
SHD3_k127_3716242_2 Domain of unknown function (DUF3821) - - - 0.000000000001608 74.0
SHD3_k127_371899_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 2.896e-206 652.0
SHD3_k127_371899_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 583.0
SHD3_k127_371899_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 456.0
SHD3_k127_371899_3 Domain of unknown function (DUF4445) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 431.0
SHD3_k127_371899_4 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 355.0
SHD3_k127_371899_5 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.0000000000000000000000000000003003 137.0
SHD3_k127_3729147_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 589.0
SHD3_k127_3729147_1 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 404.0
SHD3_k127_3729147_2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 342.0
SHD3_k127_3729147_3 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000003128 222.0
SHD3_k127_3729147_4 - - - - 0.00000000000000000000000000000000000000401 153.0
SHD3_k127_3729147_5 Belongs to the UPF0434 family - - - 0.0000000000000000001025 91.0
SHD3_k127_3729147_6 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000005208 62.0
SHD3_k127_3781051_0 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 6.192e-197 618.0
SHD3_k127_3781051_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 589.0
SHD3_k127_3781051_2 PFAM ATP-binding region, ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 446.0
SHD3_k127_3781051_3 PFAM ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 337.0
SHD3_k127_3781051_4 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 324.0
SHD3_k127_3781051_5 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002248 280.0
SHD3_k127_3781051_6 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000007342 227.0
SHD3_k127_3781051_7 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000000000000000000000000000000257 173.0
SHD3_k127_3781051_8 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000002419 70.0
SHD3_k127_3791172_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000006165 155.0
SHD3_k127_3791172_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.00000000000000000000002542 114.0
SHD3_k127_3796679_0 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 344.0
SHD3_k127_3796679_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000985 290.0
SHD3_k127_3796679_2 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000005302 87.0
SHD3_k127_3803464_0 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 463.0
SHD3_k127_3803464_1 DNA methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 385.0
SHD3_k127_3803464_2 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 352.0
SHD3_k127_3803464_3 Mediates influx of magnesium ions K03284 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000874 265.0
SHD3_k127_3829556_0 PFAM Radical SAM domain protein K06937 - - 3.866e-207 653.0
SHD3_k127_3829556_1 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 563.0
SHD3_k127_3829556_2 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 432.0
SHD3_k127_3829556_3 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000000000000000000000000005596 204.0
SHD3_k127_3829556_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000003799 198.0
SHD3_k127_3835129_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 500.0
SHD3_k127_3835129_1 Bacterial Na+/H+ antiporter B (NhaB) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 439.0
SHD3_k127_3835129_2 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000002075 207.0
SHD3_k127_3838206_0 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 342.0
SHD3_k127_3838206_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000213 213.0
SHD3_k127_3838206_2 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000000003329 156.0
SHD3_k127_3838206_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.0000000000000000001521 88.0
SHD3_k127_3838206_4 Probably involved in the biogenesis of the ribosome K14561 - - 0.000000008064 61.0
SHD3_k127_3840098_1 - - - - 0.000000000000000000000000009834 119.0
SHD3_k127_3840098_2 Cupin domain - - - 0.0000000000001735 80.0
SHD3_k127_3844408_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000003249 232.0
SHD3_k127_3844408_1 Flavodoxin-like fold K00355 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000001889 229.0
SHD3_k127_3844408_2 PFAM AMMECR1 domain protein K09141 - - 0.00000000000000000000000000000000000000000000000000000000000000007969 226.0
SHD3_k127_3844408_3 Archaeal Type IV pilin, N-terminal - - - 0.000000000000421 70.0
SHD3_k127_3875343_0 HWE histidine kinase - - - 0.000000000000000000000000000003476 136.0
SHD3_k127_3875343_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000116 93.0
SHD3_k127_3875343_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000001334 80.0
SHD3_k127_3875343_3 PFAM ATP-binding region ATPase domain protein - - - 0.000000002753 65.0
SHD3_k127_3883968_0 TIGRFAM small GTP-binding protein K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 578.0
SHD3_k127_3883968_1 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 385.0
SHD3_k127_3883968_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003197 238.0
SHD3_k127_3883968_3 PFAM PKD domain containing protein - - - 0.0000000000000000371 83.0
SHD3_k127_3883968_4 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000001337 65.0
SHD3_k127_3898497_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 7.779e-194 612.0
SHD3_k127_3898497_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 584.0
SHD3_k127_3898497_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 391.0
SHD3_k127_3898497_3 - - - - 0.0001812 44.0
SHD3_k127_3914223_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 493.0
SHD3_k127_3914223_1 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 416.0
SHD3_k127_3914223_2 PFAM ABC-1 domain protein K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008169 364.0
SHD3_k127_3914223_3 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000588 236.0
SHD3_k127_3927227_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1496.0
SHD3_k127_3927227_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1022.0
SHD3_k127_3927227_10 - - - - 0.0000000000000000002179 99.0
SHD3_k127_3927227_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 3.364e-227 728.0
SHD3_k127_3927227_3 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 8.345e-220 694.0
SHD3_k127_3927227_4 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 359.0
SHD3_k127_3927227_5 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 304.0
SHD3_k127_3927227_6 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000007082 205.0
SHD3_k127_3927227_7 TIGRFAM methionine-R-sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000001426 189.0
SHD3_k127_3927227_8 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000007393 205.0
SHD3_k127_3927227_9 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000000000000001836 137.0
SHD3_k127_3938625_0 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 387.0
SHD3_k127_3938625_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000797 276.0
SHD3_k127_3938625_2 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001345 259.0
SHD3_k127_3938625_3 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000001063 239.0
SHD3_k127_3938625_4 - - - - 0.000000000000000000000000000000000000000000000000000000007335 221.0
SHD3_k127_3938625_5 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000003115 179.0
SHD3_k127_3938625_6 Protein of unknown function (DUF1616) - - - 0.000000000000000000001085 106.0
SHD3_k127_3946625_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 523.0
SHD3_k127_3946625_1 PFAM peptidase U32 K08303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 486.0
SHD3_k127_3946625_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 431.0
SHD3_k127_3946625_3 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000001658 156.0
SHD3_k127_3946625_4 Belongs to the UPF0235 family K09131 - - 0.0000000000000000000002159 101.0
SHD3_k127_3946625_5 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000001193 96.0
SHD3_k127_3953444_0 PFAM ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 369.0
SHD3_k127_3953444_1 sugar phosphatases of the HAD superfamily K02566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000104 257.0
SHD3_k127_3953444_2 - - - - 0.000000000000000000000000000000000000000000000000000000000004077 227.0
SHD3_k127_3953444_3 PFAM SufBD protein K07033 - - 0.000005354 55.0
SHD3_k127_395361_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 4.007e-256 796.0
SHD3_k127_395361_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 602.0
SHD3_k127_395361_2 - - - - 0.0000000000000000000000000000000000000000000000009625 183.0
SHD3_k127_395361_3 Uncharacterised protein family UPF0058 - - - 0.0000000000000000000000000000000000006088 142.0
SHD3_k127_395361_4 HEAT repeats - - - 0.00000000000000000000000000003991 123.0
SHD3_k127_3955799_0 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000235 191.0
SHD3_k127_3955799_1 PFAM Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000004522 179.0
SHD3_k127_3955799_2 - - - - 0.0000000000000000000009324 97.0
SHD3_k127_3990401_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 1.56e-219 689.0
SHD3_k127_3990401_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 2.281e-211 664.0
SHD3_k127_3990401_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 426.0
SHD3_k127_3990401_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005041 427.0
SHD3_k127_3990401_4 V4R K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001909 256.0
SHD3_k127_3990401_5 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000001277 244.0
SHD3_k127_3990401_6 WLM domain K07043 - - 0.00000000000000000000000000000000000000006287 160.0
SHD3_k127_3990401_7 Phosphate-starvation-inducible E - - - 0.00000000000000001065 90.0
SHD3_k127_4008664_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 7.465e-224 717.0
SHD3_k127_4008664_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000007444 261.0
SHD3_k127_4008664_2 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000006271 128.0
SHD3_k127_4034717_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000001643 168.0
SHD3_k127_4034717_1 Cupin domain - - - 0.000000000000000000000000000000000000000000001669 168.0
SHD3_k127_4034717_2 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000009238 101.0
SHD3_k127_4063474_0 PFAM Cys Met metabolism K01740 - 2.5.1.49 1.898e-215 675.0
SHD3_k127_4063474_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 309.0
SHD3_k127_4063522_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.55e-198 625.0
SHD3_k127_4063522_1 PFAM regulatory protein, ArsR K07721 - - 0.0000000000000000000000000000000000000000000000004919 196.0
SHD3_k127_4063522_2 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000000003682 86.0
SHD3_k127_4082360_0 TIGRFAM PAS sensor protein - - - 0.000000000000196 79.0
SHD3_k127_4082360_1 PFAM PKD domain containing protein - - - 0.000000000004076 77.0
SHD3_k127_4082360_2 GYD domain - - - 0.000224 48.0
SHD3_k127_4091110_0 PFAM Cysteine-rich small domain K02232,K04720,K05934,K07162,K08260 - 2.1.1.131,3.5.1.90,4.1.1.81,6.3.5.10 0.0000000000000000000000000000000000000002 158.0
SHD3_k127_4091110_1 Domain of unknown function (DUF1858) - - - 0.00000000000000000000003578 101.0
SHD3_k127_4091110_2 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000273 85.0
SHD3_k127_4098385_0 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007987 583.0
SHD3_k127_4098385_1 cadmium-exporting ATPase K01534 - 3.6.3.3,3.6.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 531.0
SHD3_k127_4098385_2 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007107 497.0
SHD3_k127_4098385_3 Flavodoxin-like fold K00355 - 1.6.5.2 0.00000000000000000000000000000000000000000007463 168.0
SHD3_k127_4098385_4 DGC domain - - - 0.00000000000000000000000000000000000007325 149.0
SHD3_k127_4098385_5 PFAM regulatory protein, ArsR K21903 - - 0.00000000000000000000000000000001312 130.0
SHD3_k127_4098385_6 TIGRFAM C_GCAxxG_C_C family - - - 0.000000000000000000000000000000871 128.0
SHD3_k127_4098385_7 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.00000000000000000000000001089 115.0
SHD3_k127_4098385_8 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000009464 99.0
SHD3_k127_4098385_9 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000002602 49.0
SHD3_k127_4101741_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 556.0
SHD3_k127_4101741_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005787 521.0
SHD3_k127_4101741_2 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006562 346.0
SHD3_k127_4101741_3 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 326.0
SHD3_k127_4101741_4 cytidyltransferase-related domain K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000000000000000112 260.0
SHD3_k127_4101741_5 - - - - 0.00000000000000000000000000000005789 127.0
SHD3_k127_4101741_6 - K00960 - 2.7.7.6 0.000000000000000000000000002894 112.0
SHD3_k127_4101741_7 Transglutaminase-like superfamily - - - 0.00000000000000000000000001045 126.0
SHD3_k127_4101741_8 - - - - 0.00000000000000000000000002937 111.0
SHD3_k127_4101741_9 phosphohydrolase (DHH superfamily) K07097 - - 0.00000000000000000000001711 100.0
SHD3_k127_4140761_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 404.0
SHD3_k127_4140761_1 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005859 327.0
SHD3_k127_4140761_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 319.0
SHD3_k127_4140761_3 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 294.0
SHD3_k127_4140761_4 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000000000000000000002718 221.0
SHD3_k127_4140761_5 Yip1 domain - - - 0.0000000000000000000000000000000000000000000000000000005752 201.0
SHD3_k127_4140761_6 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000091 193.0
SHD3_k127_4160694_0 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 578.0
SHD3_k127_4160694_1 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000001024 117.0
SHD3_k127_4160694_2 PFAM PKD domain containing protein - - - 0.000000000000000000000008603 115.0
SHD3_k127_4186218_0 PFAM glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009649 465.0
SHD3_k127_4186218_1 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 434.0
SHD3_k127_4186218_2 Glycogen debranching enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 330.0
SHD3_k127_4186218_3 - - - - 0.000000000000000000000000000000000000000000000004194 181.0
SHD3_k127_4196150_0 Multicopper - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 571.0
SHD3_k127_4196150_1 phosphoesterase RecJ domain protein - - - 0.0000000000000000000000000000000003743 136.0
SHD3_k127_4205992_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 7.984e-263 818.0
SHD3_k127_4205992_1 PFAM helix-turn-helix HxlR type - - - 0.000000000000000002196 86.0
SHD3_k127_4221425_0 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000131 287.0
SHD3_k127_4221425_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000004368 91.0
SHD3_k127_4226201_0 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 312.0
SHD3_k127_4226201_1 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000216 245.0
SHD3_k127_4226201_2 transcription factor (CBF NF-Y) - - - 0.00000000000000000000000002324 115.0
SHD3_k127_4226201_3 methanogen marker protein 4 - - - 0.0000000000000000005213 87.0
SHD3_k127_4237311_0 PFAM PKD domain containing protein - - - 0.0000000007049 66.0
SHD3_k127_4278454_0 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000006061 205.0
SHD3_k127_4278454_1 Sugar-specific transcriptional regulator TrmB - - - 0.000000000000006703 78.0
SHD3_k127_4278454_2 Nitrite and sulphite reductase 4Fe-4S domain - - - 0.00000000000002294 75.0
SHD3_k127_4278454_4 Alpha/beta hydrolase family - - - 0.000000006287 63.0
SHD3_k127_4278454_5 4Fe-4S binding domain protein - - - 0.0000879 45.0
SHD3_k127_4278454_6 GYD domain - - - 0.0007176 49.0
SHD3_k127_4281153_0 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 323.0
SHD3_k127_4281153_1 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 285.0
SHD3_k127_4281153_2 CorA-like Mg2+ transporter protein K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000186 231.0
SHD3_k127_4281153_3 archaeal Zn-finger protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002483 226.0
SHD3_k127_4281153_4 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000000000000004416 155.0
SHD3_k127_4281153_5 UPF0391 membrane protein - - - 0.0000000001249 63.0
SHD3_k127_4281153_6 Predicted membrane protein (DUF2085) - - - 0.000000001436 68.0
SHD3_k127_4295208_0 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 462.0
SHD3_k127_4295208_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 439.0
SHD3_k127_4295208_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000006067 250.0
SHD3_k127_4297073_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008318 562.0
SHD3_k127_4297073_1 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000004451 143.0
SHD3_k127_4299164_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 501.0
SHD3_k127_4299164_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 465.0
SHD3_k127_4299164_10 - - - - 0.00000000006631 72.0
SHD3_k127_4299164_2 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 321.0
SHD3_k127_4299164_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008243 282.0
SHD3_k127_4299164_4 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000000004977 210.0
SHD3_k127_4299164_5 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000005542 158.0
SHD3_k127_4299164_6 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000000000000003846 121.0
SHD3_k127_4299164_7 protein conserved in archaea - - - 0.000000000000000000000000005779 122.0
SHD3_k127_4299164_8 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000000000005111 110.0
SHD3_k127_4299164_9 Transcriptional regulator K07108 - - 0.00000000000000000003145 91.0
SHD3_k127_4301709_0 PFAM NADH Ubiquinone plastoquinone (complex I) K14086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 503.0
SHD3_k127_432034_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0 1451.0
SHD3_k127_4328596_0 Belongs to the UPF0218 family K09735 - - 0.000000000000000000000000000000000000000004765 164.0
SHD3_k127_4328596_1 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000000000001519 116.0
SHD3_k127_4328596_2 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.0000000000000000000000000004044 115.0
SHD3_k127_4328596_3 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.000000000000000002531 90.0
SHD3_k127_4328596_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000007389 48.0
SHD3_k127_4338692_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 606.0
SHD3_k127_4338692_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 532.0
SHD3_k127_4338692_2 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 392.0
SHD3_k127_4338692_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 386.0
SHD3_k127_4338692_4 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002365 278.0
SHD3_k127_4338692_5 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.000000000000000000000000000000000007973 146.0
SHD3_k127_4344941_0 DEAD DEAH box helicase domain protein K03725 - - 1.141e-296 936.0
SHD3_k127_4344941_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 598.0
SHD3_k127_4344941_2 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 357.0
SHD3_k127_4344941_3 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008042 257.0
SHD3_k127_4344999_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 558.0
SHD3_k127_4344999_1 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 451.0
SHD3_k127_4344999_10 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000002675 88.0
SHD3_k127_4344999_11 PFAM Radical SAM domain protein - - - 0.00000000000001008 75.0
SHD3_k127_4344999_12 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000000148 73.0
SHD3_k127_4344999_2 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 435.0
SHD3_k127_4344999_3 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 393.0
SHD3_k127_4344999_4 Translation initiation factor 2 alpha subunit K03237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 379.0
SHD3_k127_4344999_5 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 298.0
SHD3_k127_4344999_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000005219 178.0
SHD3_k127_4344999_7 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000001809 168.0
SHD3_k127_4344999_8 protein conserved in archaea K09723 - - 0.00000000000000000000000000001424 126.0
SHD3_k127_4344999_9 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000000000000000003997 113.0
SHD3_k127_4348790_0 PFAM ABC-1 domain protein K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 418.0
SHD3_k127_4348790_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003315 278.0
SHD3_k127_4356613_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 585.0
SHD3_k127_4356613_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 521.0
SHD3_k127_4356613_2 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004633 331.0
SHD3_k127_4356613_3 - - - - 0.00000000000000000000000000000008562 130.0
SHD3_k127_4356613_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000001887 108.0
SHD3_k127_4356613_5 Belongs to the UPF0280 family K09740 - - 0.00007494 46.0
SHD3_k127_4361753_0 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000005524 160.0
SHD3_k127_4361753_1 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000000000001094 154.0
SHD3_k127_4361753_2 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000005712 57.0
SHD3_k127_4372168_0 - - - - 0.000000000000000000000000000000000000000000000000000000528 197.0
SHD3_k127_4372168_1 B-block binding subunit of TFIIIC - - - 0.00000000000000000000005974 98.0
SHD3_k127_4372168_2 - - - - 0.000000000000000000003355 105.0
SHD3_k127_4379423_0 PFAM Metallophosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000008207 211.0
SHD3_k127_4379423_1 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000001774 164.0
SHD3_k127_4379423_2 - K00960 - 2.7.7.6 0.0000000000000000000000007677 104.0
SHD3_k127_4394486_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006672 314.0
SHD3_k127_4394486_1 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000002575 198.0
SHD3_k127_4394486_2 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.000000000000000000000000000000001815 139.0
SHD3_k127_4404800_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 533.0
SHD3_k127_4404800_1 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 361.0
SHD3_k127_4404800_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008832 275.0
SHD3_k127_4404800_3 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000001015 254.0
SHD3_k127_4404800_4 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000009194 170.0
SHD3_k127_4404800_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 0.000000000002233 80.0
SHD3_k127_4404800_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000002612 57.0
SHD3_k127_4408543_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000189 150.0
SHD3_k127_4408543_1 DSBA-like thioredoxin domain - - - 0.00000000000000000000000008011 109.0
SHD3_k127_4418996_0 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 528.0
SHD3_k127_4418996_1 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009744 325.0
SHD3_k127_4418996_2 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000002089 223.0
SHD3_k127_4418996_3 NfeD-like C-terminal, partner-binding - - - 0.00000000000000000000000000000000000000000000001755 174.0
SHD3_k127_4429687_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 495.0
SHD3_k127_4429687_1 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000000001776 237.0
SHD3_k127_4429687_2 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002448 243.0
SHD3_k127_4429687_3 Short repeat of unknown function (DUF308) - - - 0.00000000000000000001586 104.0
SHD3_k127_4429687_4 Contains one ATP-binding region, ATPase-like domain (IPR003594) - - - 0.00000000000001909 83.0
SHD3_k127_4429687_5 TIGRFAM PAS sensor protein - - - 0.0003791 49.0
SHD3_k127_4456599_0 PFAM phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008157 471.0
SHD3_k127_4456599_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 412.0
SHD3_k127_4456599_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007648 353.0
SHD3_k127_4456599_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000923 293.0
SHD3_k127_4456599_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000003135 247.0
SHD3_k127_4456599_5 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000002837 240.0
SHD3_k127_4456599_6 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.0000000000000000000000000000002268 123.0
SHD3_k127_4456599_7 - K06193 - - 0.000001063 62.0
SHD3_k127_446041_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 1.847e-213 670.0
SHD3_k127_446041_1 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.0000000000000000000000000000000000000000000000000000368 191.0
SHD3_k127_446041_2 PFAM Yip1 domain - - - 0.0000000000000000000000000000001034 133.0
SHD3_k127_446041_3 Secreted and surface protein containing fasciclin-like repeats - - - 0.000000000000000000000000001338 117.0
SHD3_k127_446041_4 PFAM Yip1 domain - - - 0.0000000000000000000000001 114.0
SHD3_k127_446041_5 PFAM Yip1 domain - - - 0.00000000000002954 82.0
SHD3_k127_446041_6 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000004058 55.0
SHD3_k127_4462424_0 Pfam:KaiC K08482 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 445.0
SHD3_k127_4462424_1 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 424.0
SHD3_k127_4462424_2 PFAM response regulator receiver - - - 0.00000000000000000000000000000000000000000000004996 191.0
SHD3_k127_4462424_3 KaiB domain K08481 - - 0.000000000000000000000000000000000000002712 149.0
SHD3_k127_4463745_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 469.0
SHD3_k127_4463745_1 Uncharacterised conserved protein (DUF2156) K01163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 402.0
SHD3_k127_4463745_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000253 148.0
SHD3_k127_4463745_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.0000000000000000000000000000000000007646 142.0
SHD3_k127_4463745_4 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K07533 - 5.2.1.8 0.0000000000000000000000000000000071 129.0
SHD3_k127_4463745_5 Membrane transport protein K07088 - - 0.00000009415 61.0
SHD3_k127_4470884_0 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 316.0
SHD3_k127_4470884_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 307.0
SHD3_k127_4470884_2 Pas domain - - - 0.0000000000000000000000000000000000000000000000003345 192.0
SHD3_k127_4470884_3 SMART protein phosphatase 2C domain protein - - - 0.0000261 56.0
SHD3_k127_4473168_0 Glycoside hydrolase family 28 - - - 0.000000000000000000000000000000000000000000000000000000000000000028 247.0
SHD3_k127_4473168_1 PFAM PEGA domain - - - 0.0008364 52.0
SHD3_k127_4497976_0 Co Zn Cd efflux system component K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000001953 239.0
SHD3_k127_4497976_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000002246 124.0
SHD3_k127_4498006_0 Glycoside hydrolase family 28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 306.0
SHD3_k127_4501578_0 Predicted membrane protein (DUF2070) K08979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 537.0
SHD3_k127_4501578_1 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000217 282.0
SHD3_k127_4504641_0 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 382.0
SHD3_k127_4504641_1 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000000000000001227 199.0
SHD3_k127_4504641_2 Zn-ribbon containing protein K07163 - - 0.000000000000000000000000000000000002264 147.0
SHD3_k127_45194_0 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 361.0
SHD3_k127_45194_1 to orf2, orf11, orf12, orf13, orf14, orf15 of fosmid clone 4B7mr3 - - - 0.00000000000000000000000000000000000000000000000000749 193.0
SHD3_k127_4531143_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 514.0
SHD3_k127_4531143_1 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002734 232.0
SHD3_k127_4531143_2 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000009875 191.0
SHD3_k127_4534300_0 PFAM CBS domain - - - 3.192e-234 733.0
SHD3_k127_4534300_1 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002658 278.0
SHD3_k127_4534300_2 Belongs to the UPF0280 family K09740 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005845 256.0
SHD3_k127_4534300_3 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009242 260.0
SHD3_k127_4534300_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000003553 197.0
SHD3_k127_4534300_5 - - - - 0.000000000000000000003607 95.0
SHD3_k127_4534300_6 zinc finger, SWIM - - - 0.000000000000000000004102 96.0
SHD3_k127_4536067_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.0000000000000000000000000000000000000000000000005627 179.0
SHD3_k127_4536067_1 Belongs to the UPF0147 family K09721 - - 0.000000000000000000000000000000000000000568 150.0
SHD3_k127_4536067_2 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.000000000000002226 80.0
SHD3_k127_4536067_3 DEAD DEAH box helicase domain protein K10896 - - 0.00000002364 56.0
SHD3_k127_4570869_0 Alpha/beta hydrolase family K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 513.0
SHD3_k127_4570869_1 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 348.0
SHD3_k127_4570869_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 331.0
SHD3_k127_4570869_3 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases K03641 - - 0.0000000000000000000000000104 122.0
SHD3_k127_4570869_4 PFAM WD40 domain protein beta Propeller - - - 0.00006318 53.0
SHD3_k127_4572693_0 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 407.0
SHD3_k127_4572693_1 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008419 372.0
SHD3_k127_4593942_0 Methyltransferase type - - - 0.0000000000000000000000000000000000000000000000000000000001036 213.0
SHD3_k127_4593942_1 Armadillo/beta-catenin-like repeats - - - 0.0000000001463 72.0
SHD3_k127_4601278_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 499.0
SHD3_k127_4601278_1 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 325.0
SHD3_k127_4601278_2 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000000000000000000000002009 176.0
SHD3_k127_4601278_3 TfuA-like protein - - - 0.0000000000000000000000000000000007276 140.0
SHD3_k127_4601278_4 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000001922 81.0
SHD3_k127_4601278_5 Metallo-beta-lactamase superfamily K02238 - - 0.0000001494 57.0
SHD3_k127_4605828_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 374.0
SHD3_k127_4605828_1 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001346 243.0
SHD3_k127_4605828_2 - - - - 0.00000000000000000000000139 111.0
SHD3_k127_4605828_3 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07006 - - 0.000000000000000000000004482 101.0
SHD3_k127_4605828_4 methyltransferase activity K21310 - 2.1.1.334 0.000000000000000000000004918 109.0
SHD3_k127_4605828_5 - - - - 0.00000008343 59.0
SHD3_k127_4605828_6 DNA binding protein K06930 - - 0.000000129 61.0
SHD3_k127_4617561_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 552.0
SHD3_k127_4617561_1 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006211 436.0
SHD3_k127_4617561_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 332.0
SHD3_k127_4617561_3 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.0000000000000000000000000000000000000000000000000001605 190.0
SHD3_k127_4617561_4 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.000000000000000000000000007478 116.0
SHD3_k127_4617561_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000008827 102.0
SHD3_k127_4625413_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005903 530.0
SHD3_k127_4625413_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 511.0
SHD3_k127_4625413_2 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009446 375.0
SHD3_k127_4625413_3 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003518 278.0
SHD3_k127_4625413_4 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000003128 271.0
SHD3_k127_4625413_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001143 243.0
SHD3_k127_4625413_6 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.0000000000000000000000000000000000000000000000002047 194.0
SHD3_k127_4625413_7 - - - - 0.000000000000003706 81.0
SHD3_k127_4628709_0 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 295.0
SHD3_k127_4628709_1 - - - - 0.00000000000000000000007726 110.0
SHD3_k127_4643020_0 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 531.0
SHD3_k127_4643020_1 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 530.0
SHD3_k127_4643020_2 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 398.0
SHD3_k127_4643020_3 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 319.0
SHD3_k127_4643020_4 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000293 238.0
SHD3_k127_4643020_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000004845 223.0
SHD3_k127_4643020_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000001301 107.0
SHD3_k127_4643020_7 - - - - 0.000000000000668 79.0
SHD3_k127_4654625_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 487.0
SHD3_k127_4654625_1 Belongs to the alkaline phosphatase family K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000004295 186.0
SHD3_k127_4654625_2 PFAM NHL repeat containing protein - - - 0.0000000000000000000000958 111.0
SHD3_k127_4654625_3 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000003487 59.0
SHD3_k127_4656949_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000694 264.0
SHD3_k127_4682028_0 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 415.0
SHD3_k127_4682028_1 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000105 275.0
SHD3_k127_4682028_2 Rhodanese Homology Domain - - - 0.000000000005295 67.0
SHD3_k127_4682028_3 Rhodanese Homology Domain - - - 0.0000001097 53.0
SHD3_k127_4693650_0 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 336.0
SHD3_k127_4693650_1 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003106 248.0
SHD3_k127_4693650_2 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000001611 213.0
SHD3_k127_4693650_3 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000000000000005006 78.0
SHD3_k127_4708256_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 401.0
SHD3_k127_4708256_1 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 332.0
SHD3_k127_4708256_4 - - - - 0.0001181 52.0
SHD3_k127_4710030_0 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 535.0
SHD3_k127_4710030_1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 357.0
SHD3_k127_4710030_2 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000001535 233.0
SHD3_k127_4710030_3 Winged helix-turn-helix - - - 0.000000000000000000000000000000000162 137.0
SHD3_k127_4710030_4 Flavodoxin domain - - - 0.000000000000000000000000000006558 134.0
SHD3_k127_4710030_5 - - - - 0.0000000000000000000000001706 115.0
SHD3_k127_4741234_0 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 518.0
SHD3_k127_4741234_1 ADP-ribosylglycohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 298.0
SHD3_k127_4741234_2 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000000000000000000000000000114 128.0
SHD3_k127_4745629_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000007016 228.0
SHD3_k127_4745629_1 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000000000000000000000000000000000000000001134 182.0
SHD3_k127_4745629_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000001735 98.0
SHD3_k127_4747294_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 3.871e-225 708.0
SHD3_k127_4747294_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 330.0
SHD3_k127_4747294_2 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000004358 203.0
SHD3_k127_4761032_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.0 1018.0
SHD3_k127_4761032_1 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 593.0
SHD3_k127_4761032_2 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 418.0
SHD3_k127_4761032_3 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 290.0
SHD3_k127_4764730_0 methanogenesis marker protein 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 349.0
SHD3_k127_4764730_1 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000001712 207.0
SHD3_k127_4764730_2 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000004945 180.0
SHD3_k127_4764730_3 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.000000000000000000000000000000000000000000004189 175.0
SHD3_k127_4764730_4 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000002996 127.0
SHD3_k127_4771190_0 Required for chromosome condensation and partitioning K03529 - - 1.286e-248 790.0
SHD3_k127_4771190_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.185e-223 703.0
SHD3_k127_4771190_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007962 496.0
SHD3_k127_4771190_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 410.0
SHD3_k127_4771190_4 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 321.0
SHD3_k127_4771190_5 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 300.0
SHD3_k127_4771190_6 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000116 265.0
SHD3_k127_4771190_7 - - - - 0.00000000000000000000000000000000003031 142.0
SHD3_k127_4776197_0 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008302 393.0
SHD3_k127_4776197_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000001568 157.0
SHD3_k127_4776197_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000001398 137.0
SHD3_k127_4776197_3 TIGRFAM PAS sensor protein - - - 0.0000000000000004136 87.0
SHD3_k127_4776197_4 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000006154 56.0
SHD3_k127_4776197_5 Histidine kinase - - - 0.0002491 51.0
SHD3_k127_4781915_0 - - - - 0.0000000000000000000000000000000000000000000000000000005188 210.0
SHD3_k127_4781915_1 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000005646 107.0
SHD3_k127_4794111_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 588.0
SHD3_k127_4794111_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007656 345.0
SHD3_k127_4794111_2 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006885 277.0
SHD3_k127_4794111_3 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000002322 180.0
SHD3_k127_4794111_4 Belongs to the UPF0216 family K09737 - - 0.000000000000000000000000007624 118.0
SHD3_k127_4794111_5 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000000000000000004575 106.0
SHD3_k127_4794111_6 YHS domain - - - 0.00000000000000000142 86.0
SHD3_k127_4794111_7 Glycosyl transferase family 2 - - - 0.000000000001242 77.0
SHD3_k127_482328_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000004365 189.0
SHD3_k127_482328_1 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000002892 165.0
SHD3_k127_4826065_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 4.19e-321 992.0
SHD3_k127_4826065_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.000000000000000000000000000000000007433 148.0
SHD3_k127_484663_0 PFAM aldo keto reductase K07079 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 535.0
SHD3_k127_484663_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 389.0
SHD3_k127_484663_2 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 310.0
SHD3_k127_484663_3 - - - - 0.000000000000000000000000000000000000000000000000000000003974 204.0
SHD3_k127_484663_4 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000000003879 177.0
SHD3_k127_484663_5 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000000000009261 171.0
SHD3_k127_4860956_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 9.481e-243 762.0
SHD3_k127_4860956_1 ArsR transcriptional regulator - - - 0.00000000002146 64.0
SHD3_k127_4872301_0 5'-nucleotidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 520.0
SHD3_k127_4872301_1 PFAM glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 472.0
SHD3_k127_4872301_2 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 409.0
SHD3_k127_4872301_3 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000244 162.0
SHD3_k127_4872301_4 - - - - 0.00000000000000000000000000000004341 137.0
SHD3_k127_4872301_5 - - - - 0.0000000000000000000003764 96.0
SHD3_k127_4906782_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 559.0
SHD3_k127_4906782_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 321.0
SHD3_k127_4906782_2 PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily K06996 - - 0.00000000000000000000000000325 115.0
SHD3_k127_491245_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 560.0
SHD3_k127_491245_1 PFAM Aminotransferase class I and II K05825 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 488.0
SHD3_k127_491245_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 309.0
SHD3_k127_491245_3 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003601 266.0
SHD3_k127_491245_4 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000004092 247.0
SHD3_k127_491245_5 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000000000000000000000000000000002282 220.0
SHD3_k127_491245_6 pathogenesis - - - 0.000000000000000000000000000000000000000003535 163.0
SHD3_k127_491245_7 - - - - 0.000000000000000000000000000000000002781 149.0
SHD3_k127_491245_8 Glutaredoxin - - - 0.00000000000000000000000000000001316 138.0
SHD3_k127_491245_9 VTC domain - - - 0.0000000000000000000000001064 117.0
SHD3_k127_4912932_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 413.0
SHD3_k127_4912932_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001618 266.0
SHD3_k127_4912932_2 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000000000000003385 194.0
SHD3_k127_4953568_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 614.0
SHD3_k127_4961277_0 stage II sporulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 497.0
SHD3_k127_4979545_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000001275 110.0
SHD3_k127_4979545_1 SMART cellulose binding type IV K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000002901 95.0
SHD3_k127_5007039_0 PFAM Cobalt transport protein K16785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 304.0
SHD3_k127_5007039_1 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 298.0
SHD3_k127_5007039_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000003735 196.0
SHD3_k127_5037473_0 COG0110 Acetyltransferase (isoleucine patch superfamily) K00661 - 2.3.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000004674 269.0
SHD3_k127_5037473_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012,K02474 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000002534 220.0
SHD3_k127_5037473_2 - - - - 0.0000000000000000000000000000000000004925 149.0
SHD3_k127_5037473_3 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.000000000003366 69.0
SHD3_k127_5054802_0 Domain of unknown function (DUF1917) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 306.0
SHD3_k127_5054802_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000001851 252.0
SHD3_k127_5054802_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.00000000000000000000000000000000000000001204 156.0
SHD3_k127_5054802_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000002206 93.0
SHD3_k127_5056622_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1268.0
SHD3_k127_5056622_1 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.000000000000000000000001212 106.0
SHD3_k127_5056622_2 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000005314 100.0
SHD3_k127_5056622_3 lactoylglutathione lyase activity - - - 0.0000000000000000000364 104.0
SHD3_k127_5056622_4 Putative zinc ribbon domain - - - 0.0000000000000001857 90.0
SHD3_k127_5056622_5 Protein of unknown function (DUF541) K09807 - - 0.000000002804 66.0
SHD3_k127_5112733_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000001879 111.0
SHD3_k127_5112733_1 Pyruvate kinase, alpha/beta domain K09126 - - 0.0000001252 58.0
SHD3_k127_5113889_0 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 318.0
SHD3_k127_5113889_1 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000403 273.0
SHD3_k127_5113889_2 - - - - 0.00000000000003796 75.0
SHD3_k127_5113889_3 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.000000001039 63.0
SHD3_k127_5123361_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 3.062e-216 682.0
SHD3_k127_5123361_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007158 453.0
SHD3_k127_5123361_2 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000214 254.0
SHD3_k127_5123361_3 Belongs to the UPF0179 family K09730 - - 0.00000000000000000000000000000000000000000000000000000000000002554 218.0
SHD3_k127_5123361_4 metal-binding protein - - - 0.0000000000000000000001115 100.0
SHD3_k127_5123361_5 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000001513 104.0
SHD3_k127_5148694_0 Predicted membrane protein (DUF2206) - - - 2.515e-294 921.0
SHD3_k127_5148694_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 429.0
SHD3_k127_5148694_2 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 430.0
SHD3_k127_5148694_3 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002287 264.0
SHD3_k127_5148694_4 amino acid-binding ACT domain protein - - - 0.000003989 49.0
SHD3_k127_516575_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 538.0
SHD3_k127_516575_1 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.00000000000000000000000000000000000000000001463 175.0
SHD3_k127_516575_2 Protein of unknown function (DUF3795) - - - 0.00000000000000000000000005323 124.0
SHD3_k127_516575_3 GYD domain - - - 0.000000000000000003357 87.0
SHD3_k127_5183537_0 ATPases associated with a variety of cellular activities K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006738 269.0
SHD3_k127_5183537_1 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000000000000001791 224.0
SHD3_k127_5183537_2 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.00000000000000000000000000000000000000000000000000000000000008993 217.0
SHD3_k127_5183537_3 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000236 235.0
SHD3_k127_5183537_4 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000005024 206.0
SHD3_k127_5183537_5 - - - - 0.00000000000000000000000000000000000000000000000000003658 190.0
SHD3_k127_5191495_0 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 351.0
SHD3_k127_5191495_1 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005313 278.0
SHD3_k127_5191495_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000135 276.0
SHD3_k127_5191495_3 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000000000001016 182.0
SHD3_k127_5210848_0 Male sterility protein K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 477.0
SHD3_k127_5210848_1 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 456.0
SHD3_k127_5210848_2 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 391.0
SHD3_k127_5210848_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 364.0
SHD3_k127_5210848_4 WxcM-like, C-terminal K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 282.0
SHD3_k127_5210848_5 Polysaccharide biosynthesis protein K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000002079 266.0
SHD3_k127_5210848_6 peptidase M42 family protein - - - 0.000000000000000000000000000000000000000000000000175 179.0
SHD3_k127_5213325_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 2.352e-244 770.0
SHD3_k127_5213325_1 Transport of potassium into the cell K03549 - - 1.101e-237 752.0
SHD3_k127_5213325_10 PhoU domain - - - 0.000000000000000000000000000000000000004874 148.0
SHD3_k127_5213325_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 374.0
SHD3_k127_5213325_3 Pirin K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009934 308.0
SHD3_k127_5213325_4 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000783 332.0
SHD3_k127_5213325_5 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001667 272.0
SHD3_k127_5213325_6 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003559 269.0
SHD3_k127_5213325_7 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000003073 226.0
SHD3_k127_5213325_8 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000001565 241.0
SHD3_k127_5213325_9 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000002029 183.0
SHD3_k127_5229530_0 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 1.302e-199 631.0
SHD3_k127_5229530_1 Glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 370.0
SHD3_k127_5229530_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000563 160.0
SHD3_k127_5229530_3 Protein of unknown function (DUF4013) - - - 0.00000000000000000000000000000001645 136.0
SHD3_k127_5229530_4 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.00000000000000000000000000000006207 126.0
SHD3_k127_5237985_0 COG0306 Phosphate sulphate permeases K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 347.0
SHD3_k127_5237985_1 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000001679 198.0
SHD3_k127_5237985_2 PFAM PKD domain containing protein - - - 0.0000000000000004855 89.0
SHD3_k127_5244913_0 AAA domain K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000648 374.0
SHD3_k127_5244913_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 320.0
SHD3_k127_5245686_0 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 496.0
SHD3_k127_5245686_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 437.0
SHD3_k127_5245686_2 methanogen marker protein 4 - - - 0.00000000000000000000000000000000001762 152.0
SHD3_k127_5256107_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009102 375.0
SHD3_k127_5256107_1 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 340.0
SHD3_k127_5256107_10 Helix-turn-helix domain K07729 - - 0.0000000000005132 73.0
SHD3_k127_5256107_11 - - - - 0.000000000001156 71.0
SHD3_k127_5256107_12 membrane protein (DUF2178) - - - 0.00007035 49.0
SHD3_k127_5256107_2 PFAM ABC transporter related K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 324.0
SHD3_k127_5256107_3 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 314.0
SHD3_k127_5256107_4 Lon protease (S16) C-terminal proteolytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002277 287.0
SHD3_k127_5256107_5 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000000001426 257.0
SHD3_k127_5256107_6 membrane protein (DUF2178) - - - 0.0000000000000000000000000000000000000004241 154.0
SHD3_k127_5256107_7 - - - - 0.0000000000000000000001108 103.0
SHD3_k127_5256107_8 - - - - 0.00000000000000003238 84.0
SHD3_k127_5256107_9 Helix-turn-helix XRE-family like proteins K07729 - - 0.0000000000001938 73.0
SHD3_k127_5290339_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 404.0
SHD3_k127_5290339_1 Glycosyl hydrolase family 57 K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000001068 183.0
SHD3_k127_5290339_2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.000000000000004593 76.0
SHD3_k127_529225_0 ATP-binding region, ATPase domain protein K03413,K07662,K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 499.0
SHD3_k127_529225_1 cheY-homologous receiver domain - - - 0.000000000000000000000000000000002465 131.0
SHD3_k127_5298265_0 TIGRFAM Por secretion system C-terminal sorting domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009433 352.0
SHD3_k127_5298265_1 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000008568 137.0
SHD3_k127_5298265_2 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000001422 140.0
SHD3_k127_5298265_3 PFAM PKD domain containing protein - - - 0.0000000000000000001477 104.0
SHD3_k127_5298265_4 WD40-like Beta Propeller Repeat K03641 - - 0.0005072 51.0
SHD3_k127_5300745_0 Glycoside hydrolase family 28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009186 567.0
SHD3_k127_5300745_1 SMART Elongator protein 3 MiaB NifB K22226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 415.0
SHD3_k127_5300745_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.0000000000000000000000002748 109.0
SHD3_k127_5300745_3 PspC domain K03973 - - 0.0000000000000001247 83.0
SHD3_k127_5300745_4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.0000000003325 70.0
SHD3_k127_5319832_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000003726 164.0
SHD3_k127_5325438_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 512.0
SHD3_k127_5325438_1 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 465.0
SHD3_k127_5325438_2 helicase activity K06915 - - 0.000000000000000000000009092 108.0
SHD3_k127_5325438_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000006218 78.0
SHD3_k127_5331552_0 deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 374.0
SHD3_k127_5331552_1 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000006689 215.0
SHD3_k127_5331552_2 Armadillo/beta-catenin-like repeats - - - 0.000000000000000000002386 105.0
SHD3_k127_5331552_3 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000001468 83.0
SHD3_k127_5340920_0 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 379.0
SHD3_k127_5340920_1 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004372 349.0
SHD3_k127_5340920_2 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000000006981 203.0
SHD3_k127_5340920_3 NMT1-like family K02051 - - 0.00000000009036 62.0
SHD3_k127_5343956_0 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000009975 249.0
SHD3_k127_5343956_1 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000004891 143.0
SHD3_k127_5343956_2 HIT domain - - - 0.0000000000000000000000000000000005159 139.0
SHD3_k127_5343956_3 integral membrane protein - - - 0.00000000000000000000004002 108.0
SHD3_k127_5345754_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 335.0
SHD3_k127_5345754_1 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000005791 139.0
SHD3_k127_5345754_2 PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily K06996 - - 0.00000002273 56.0
SHD3_k127_5356925_0 Carbohydrate binding family 6 K01179 - 3.2.1.4 6.988e-194 615.0
SHD3_k127_5369119_0 redox protein regulator of disulfide bond formation - - - 0.000000000000000000000000000004534 124.0
SHD3_k127_5369539_0 DEAD DEAH box helicase domain protein K03724 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 514.0
SHD3_k127_5369539_1 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 323.0
SHD3_k127_5369539_2 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.00000000003669 65.0
SHD3_k127_5393119_0 PFAM ABC transporter K00400 - - 1.023e-273 849.0
SHD3_k127_5393119_1 Belongs to the UPF0288 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 574.0
SHD3_k127_5393119_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 554.0
SHD3_k127_5393119_3 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 415.0
SHD3_k127_5393119_4 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000811 266.0
SHD3_k127_5393119_5 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004207 246.0
SHD3_k127_5393119_6 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000001186 186.0
SHD3_k127_5393119_7 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000000000000000964 171.0
SHD3_k127_5393270_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 440.0
SHD3_k127_5393270_1 Membrane - - - 0.000000000000000000000000000002652 124.0
SHD3_k127_5393270_2 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000001327 118.0
SHD3_k127_5394123_0 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007119 353.0
SHD3_k127_5394123_1 amino acid K16263 - - 0.000000000000000000000000000000000000000000000000001246 198.0
SHD3_k127_5394123_2 Domain of unknown function (DUF371) K09738 - - 0.00000000000000000000000000000000000000000002395 164.0
SHD3_k127_5394123_3 Acyl-CoA thioester hydrolase/BAAT N-terminal region K06889 - - 0.00000002573 58.0
SHD3_k127_5394123_4 exodeoxyribonuclease VII activity K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.00009747 47.0
SHD3_k127_5396282_0 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 591.0
SHD3_k127_5396282_1 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006232 249.0
SHD3_k127_5396282_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000008944 234.0
SHD3_k127_5396282_3 Histidine kinase K02482 - 2.7.13.3 0.000000000068 68.0
SHD3_k127_5410206_0 oligopeptide transport K03305 - - 2.939e-261 817.0
SHD3_k127_5410206_1 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006999 325.0
SHD3_k127_5410206_2 TIGRFAM channel protein, hemolysin III family K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000001869 234.0
SHD3_k127_5410206_3 GDSL-like Lipase/Acylhydrolase - - - 0.0001093 52.0
SHD3_k127_5411007_0 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 615.0
SHD3_k127_5411007_1 Sulfide dehydrogenase (Flavoprotein) subunit SudB K00528,K02823 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 412.0
SHD3_k127_5411007_2 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.00000000000000000169 88.0
SHD3_k127_5411007_3 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.0000000001062 64.0
SHD3_k127_5435504_0 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 460.0
SHD3_k127_5435504_1 Glycoside hydrolase family 28 K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007476 416.0
SHD3_k127_5435504_2 toxin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000006081 244.0
SHD3_k127_5435504_3 Glycoside hydrolase family 28 - - - 0.0000000000000000000000000000000000000005848 151.0
SHD3_k127_5435504_4 toxin activity - - - 0.00000000000000005871 88.0
SHD3_k127_5460000_0 membrane-associated protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003623 247.0
SHD3_k127_5468729_0 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 315.0
SHD3_k127_5468729_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 318.0
SHD3_k127_5468729_2 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 309.0
SHD3_k127_5468729_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000001401 171.0
SHD3_k127_5468729_4 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000001174 149.0
SHD3_k127_5472851_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 559.0
SHD3_k127_5472851_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 470.0
SHD3_k127_5472851_2 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 347.0
SHD3_k127_5472851_3 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000005236 159.0
SHD3_k127_5472851_4 - - - - 0.00000000000000000000000000000000000000004231 153.0
SHD3_k127_5472851_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.00000000000000000000000000000000000004909 144.0
SHD3_k127_5472851_6 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000006379 103.0
SHD3_k127_5473129_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 594.0
SHD3_k127_5473129_1 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 355.0
SHD3_k127_5473129_2 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 352.0
SHD3_k127_5473129_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003475 334.0
SHD3_k127_5473129_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 317.0
SHD3_k127_5473129_5 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000002672 263.0
SHD3_k127_5473129_6 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000000000000000000000000000000000000000001337 171.0
SHD3_k127_5473129_7 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.000000001739 63.0
SHD3_k127_5474033_0 Ferrous iron transport B domain protein K04759 - - 2.251e-242 772.0
SHD3_k127_5474033_1 Helix-hairpin-helix domain K02347 - - 1.863e-199 636.0
SHD3_k127_5474033_2 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000001713 263.0
SHD3_k127_5474033_3 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000000000000000000000002219 220.0
SHD3_k127_5474033_4 Mn-dependent transcriptional regulator K03709 - - 0.0000000000000000000000000001375 131.0
SHD3_k127_5474033_5 secretion by the type IV secretion system K07332 - - 0.00000000000008221 81.0
SHD3_k127_5481994_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 3.839e-230 727.0
SHD3_k127_5481994_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 574.0
SHD3_k127_5481994_2 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 364.0
SHD3_k127_5481994_3 DEAD DEAH box helicase K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 361.0
SHD3_k127_5481994_4 COG1045 Serine acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000008288 243.0
SHD3_k127_5481994_5 Transcriptional regulator, TrmB - - - 0.0000000000000000000000000000000000000000004829 159.0
SHD3_k127_5481994_6 COG0526 Thiol-disulfide isomerase and thioredoxins K03671 - - 0.00000000000000000000000000000000000000003899 155.0
SHD3_k127_5482807_0 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 593.0
SHD3_k127_5482807_1 Protein of unknown function DUF116 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 458.0
SHD3_k127_5482807_2 Major Facilitator Superfamily - - - 0.0002103 45.0
SHD3_k127_549213_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 418.0
SHD3_k127_549213_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 340.0
SHD3_k127_549213_2 PFAM D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 337.0
SHD3_k127_549213_3 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000000001769 157.0
SHD3_k127_549213_4 thiolester hydrolase activity K06889 - - 0.00000000000000000000000000000000000006205 148.0
SHD3_k127_549213_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000002858 131.0
SHD3_k127_549213_6 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.0000000000000000002318 99.0
SHD3_k127_549213_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000008119 89.0
SHD3_k127_549213_8 Probably involved in the biogenesis of the ribosome K14561 - - 0.0000000000009361 75.0
SHD3_k127_549213_9 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000001626 53.0
SHD3_k127_5493568_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 459.0
SHD3_k127_5493568_1 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 295.0
SHD3_k127_5516025_0 COG0438 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 535.0
SHD3_k127_5516025_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007334 361.0
SHD3_k127_5516025_2 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006882 314.0
SHD3_k127_5516025_3 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000001692 229.0
SHD3_k127_5536149_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1012.0
SHD3_k127_5536149_1 PFAM conserved K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 400.0
SHD3_k127_5536149_10 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.000001696 50.0
SHD3_k127_5536149_2 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 395.0
SHD3_k127_5536149_3 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 318.0
SHD3_k127_5536149_4 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 325.0
SHD3_k127_5536149_5 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000002913 224.0
SHD3_k127_5536149_6 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000463 139.0
SHD3_k127_5536149_7 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000007672 94.0
SHD3_k127_5536149_8 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000007366 79.0
SHD3_k127_5536149_9 SMART cellulose binding type IV - - - 0.00000002416 63.0
SHD3_k127_5550026_0 Involved in cell shape control K22222 - - 2.993e-196 618.0
SHD3_k127_5550026_1 - - - - 0.000000000000000000000000004709 121.0
SHD3_k127_5550026_2 PFAM amine oxidase - - - 0.00000000000000000005004 92.0
SHD3_k127_5553739_0 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006205 361.0
SHD3_k127_5553739_1 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 310.0
SHD3_k127_5553739_2 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000000001123 165.0
SHD3_k127_5553739_3 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000006542 147.0
SHD3_k127_5553739_5 SNARE associated Golgi protein K03975 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000001015 100.0
SHD3_k127_5554427_0 PFAM Ferredoxin - - - 0.00000000000000000000000000000000002959 138.0
SHD3_k127_5558385_0 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 421.0
SHD3_k127_5558385_1 Auxin Efflux Carrier K07088 - - 0.00000000000000000000000000000000000000000000000000000000003944 212.0
SHD3_k127_5558385_3 META domain - - - 0.00000000000000000000000000000008255 136.0
SHD3_k127_5558385_4 META domain - - - 0.0000000000000417 83.0
SHD3_k127_5560161_0 c-type cytochrome biogenesis protein CcmF K02198 - - 0.00000000000000000000000000000000000000000000000003823 192.0
SHD3_k127_5560161_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0002794 47.0
SHD3_k127_5567720_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 8.876e-319 983.0
SHD3_k127_5567720_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 316.0
SHD3_k127_5577496_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 3.359e-200 633.0
SHD3_k127_5577496_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000236 194.0
SHD3_k127_558675_0 PFAM dihydropteroate synthase, DHPS - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 402.0
SHD3_k127_558675_1 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001053 283.0
SHD3_k127_558675_2 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000004607 258.0
SHD3_k127_558675_3 - - - - 0.000000000000000000000000000000000000003207 150.0
SHD3_k127_5622472_0 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 430.0
SHD3_k127_5622472_2 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000008984 96.0
SHD3_k127_5622472_3 - - - - 0.00000002996 63.0
SHD3_k127_5622472_5 Pyridoxamine 5'-phosphate oxidase - - - 0.000001116 53.0
SHD3_k127_5664412_0 RNA methylase K07446 - 2.1.1.213 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009066 352.0
SHD3_k127_5664412_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000001908 187.0
SHD3_k127_5664412_2 AAA-like domain K06915 - - 0.0000000000000000000000000000003258 127.0
SHD3_k127_5665165_0 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 3.262e-229 725.0
SHD3_k127_5665165_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 622.0
SHD3_k127_5665165_2 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 401.0
SHD3_k127_5665165_3 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000001665 199.0
SHD3_k127_5665165_4 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000002409 74.0
SHD3_k127_5694994_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 8.955e-260 824.0
SHD3_k127_5694994_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 312.0
SHD3_k127_5694994_2 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000003272 268.0
SHD3_k127_5694994_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001429 248.0
SHD3_k127_5694994_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000005395 167.0
SHD3_k127_5694994_5 DNA polymerase activity K02319 - 2.7.7.7 0.0000000000000000000000000000003397 129.0
SHD3_k127_5694994_6 Protein of unknown function (DUF5131) - - - 0.00000000004435 72.0
SHD3_k127_5709041_0 PFAM PKD domain containing protein K02016,K16925 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004214 640.0
SHD3_k127_5709041_1 PFAM PKD domain containing protein - - - 0.00000000000000000000000000000000000000000000000005482 181.0
SHD3_k127_5709041_2 Periplasmic copper-binding protein (NosD) - - - 0.00000000000000000000000000000000000000000000009545 195.0
SHD3_k127_5715324_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1221.0
SHD3_k127_5715324_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 9.444e-199 626.0
SHD3_k127_577340_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 2.746e-300 934.0
SHD3_k127_577340_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 332.0
SHD3_k127_577340_2 Carbohydrate binding family 6 K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000008773 204.0
SHD3_k127_577340_3 Flavodoxin - - - 0.00000000000000000000000000001997 122.0
SHD3_k127_577340_4 Chagasin family peptidase inhibitor I42 K14475 - - 0.000000000000000000345 94.0
SHD3_k127_578724_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 599.0
SHD3_k127_578724_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 438.0
SHD3_k127_578724_2 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 0.0000000000000000000000000000000000000000001549 166.0
SHD3_k127_590904_0 Heat shock 70 kDa protein K04043 - - 2.671e-273 856.0
SHD3_k127_590904_1 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000003694 169.0
SHD3_k127_600851_0 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 421.0
SHD3_k127_600851_1 Domain of unknown function (DUF1743) - - - 0.00000000000000000000000000000000000000000000000000000000000006088 225.0
SHD3_k127_600851_2 PFAM Radical SAM - - - 0.000000003142 65.0
SHD3_k127_617445_0 Putative transposon-encoded protein (DUF2080) - - - 0.0000002439 53.0
SHD3_k127_628965_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 439.0
SHD3_k127_628965_1 PFAM Cache, type 2 domain protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 358.0
SHD3_k127_638197_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 4.636e-218 700.0
SHD3_k127_638197_1 PFAM response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000002742 232.0
SHD3_k127_639392_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 1.43e-225 717.0
SHD3_k127_639392_1 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 326.0
SHD3_k127_639392_2 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 313.0
SHD3_k127_639392_3 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000747 215.0
SHD3_k127_639392_4 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000000000001022 134.0
SHD3_k127_639392_5 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000003617 63.0
SHD3_k127_643112_0 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002837 278.0
SHD3_k127_643112_1 - - - - 0.0000000000000000000000000000000000000226 147.0
SHD3_k127_647940_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.522e-223 700.0
SHD3_k127_647940_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007917 246.0
SHD3_k127_647940_2 - - - - 0.00000000000000000000000000000000000000000000000000000005146 216.0
SHD3_k127_656435_0 DEAD DEAH box helicase K06877 - - 6.334e-247 786.0
SHD3_k127_656435_1 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 599.0
SHD3_k127_656435_2 RNase_H superfamily K07502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002732 271.0
SHD3_k127_656435_3 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000002069 164.0
SHD3_k127_660054_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 4.525e-238 739.0
SHD3_k127_660054_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000262 167.0
SHD3_k127_660054_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000001608 96.0
SHD3_k127_665386_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 510.0
SHD3_k127_665386_1 Cysteine synthase A K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 400.0
SHD3_k127_668235_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 496.0
SHD3_k127_668235_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001219 260.0
SHD3_k127_694940_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1417.0
SHD3_k127_694940_1 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 592.0
SHD3_k127_694940_2 - - - - 0.0000000000000000000000000000000000000000003564 169.0
SHD3_k127_694940_3 Helix-turn-helix domain - - - 0.000000000000000000000000000006721 123.0
SHD3_k127_694940_4 Protein of unknown function (DUF2769) - - - 0.000000000000000001844 89.0
SHD3_k127_694940_5 - - - - 0.000000000000003721 81.0
SHD3_k127_694940_6 Hemerythrin HHE cation binding domain - - - 0.000000648 58.0
SHD3_k127_714176_0 2Fe-2S iron-sulfur cluster binding domain - - - 3.35e-321 992.0
SHD3_k127_714176_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 596.0
SHD3_k127_714176_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000376 219.0
SHD3_k127_740448_0 - - - - 0.00000000000000000000000000000000000000000000000000000009116 196.0
SHD3_k127_740448_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000367 124.0
SHD3_k127_753923_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 475.0
SHD3_k127_753923_1 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 312.0
SHD3_k127_753923_10 Domain of unknown function (DUF1890) - - - 0.00005047 47.0
SHD3_k127_753923_2 neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 303.0
SHD3_k127_753923_3 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000576 270.0
SHD3_k127_753923_4 Alpha/beta hydrolase family K06889 - - 0.000000000000000000000000000000000000000000000000000000007023 209.0
SHD3_k127_753923_5 Glyoxalase-like domain K06996 - - 0.000000000000000000000000000000008485 134.0
SHD3_k127_753923_6 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000001072 108.0
SHD3_k127_753923_7 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.00000000000000000000006681 98.0
SHD3_k127_753923_8 Glyoxalase-like domain K06996 - - 0.0000000000000009852 78.0
SHD3_k127_753923_9 Protein of unknown function (DUF1294) - - - 0.00000000000006419 75.0
SHD3_k127_758735_0 catalase activity K03781 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.6 1.939e-274 850.0
SHD3_k127_758735_1 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 428.0
SHD3_k127_758735_2 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 407.0
SHD3_k127_758735_3 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 287.0
SHD3_k127_758735_4 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000001314 195.0
SHD3_k127_758735_5 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000000000007157 169.0
SHD3_k127_758735_6 divalent heavy-metal cations transporter K07238 - - 0.00000000000000000000000000000000000000001506 155.0
SHD3_k127_7685_0 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 355.0
SHD3_k127_7685_1 PFAM sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002193 260.0
SHD3_k127_7685_2 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000000000000000000000000000000000005164 150.0
SHD3_k127_7685_3 PFAM sodium hydrogen exchanger - - - 0.0000000000000001071 81.0
SHD3_k127_7685_4 Sodium/hydrogen exchanger family - - - 0.000002067 55.0
SHD3_k127_793544_0 PFAM Radical SAM domain protein K02585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005534 488.0
SHD3_k127_793544_1 TGS domain protein K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 376.0
SHD3_k127_793544_10 DNA ligase D, 3-phosphoesterase domain - - - 0.00000000000000000000000000004356 118.0
SHD3_k127_793544_11 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.0000000000000005579 79.0
SHD3_k127_793544_12 PFAM Protein kinase domain - - - 0.00000006111 63.0
SHD3_k127_793544_13 DNA ligase D, 3-phosphoesterase domain - - - 0.000006933 56.0
SHD3_k127_793544_2 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 340.0
SHD3_k127_793544_3 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002163 277.0
SHD3_k127_793544_4 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003836 250.0
SHD3_k127_793544_5 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000544 211.0
SHD3_k127_793544_6 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000004962 206.0
SHD3_k127_793544_7 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000001218 172.0
SHD3_k127_793544_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000005935 145.0
SHD3_k127_793544_9 Zinc-ribbon containing domain - - - 0.000000000000000000000000000000002014 130.0
SHD3_k127_838076_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 607.0
SHD3_k127_838076_1 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 296.0
SHD3_k127_838076_2 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001049 278.0
SHD3_k127_838076_3 Roadblock LC7 family protein K06945,K07131 - - 0.00000000000000000000000000000000002149 138.0
SHD3_k127_838076_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000000000000005198 74.0
SHD3_k127_838097_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.104e-297 921.0
SHD3_k127_838097_1 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000000000000627 153.0
SHD3_k127_853350_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 2.946e-201 638.0
SHD3_k127_853350_1 Periplasmic copper-binding protein (NosD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 403.0
SHD3_k127_853350_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000004907 174.0
SHD3_k127_853350_3 beta-lactamase domain protein - - - 0.0000000000000000000000000002224 116.0
SHD3_k127_856105_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 6.428e-271 850.0
SHD3_k127_856105_1 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 584.0
SHD3_k127_856105_10 - - - - 0.0000000000000000000000000000002286 135.0
SHD3_k127_856105_11 - - - - 0.000000001171 63.0
SHD3_k127_856105_12 - - - - 0.0004736 48.0
SHD3_k127_856105_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 401.0
SHD3_k127_856105_3 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 389.0
SHD3_k127_856105_4 Stage II sporulation protein E K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 314.0
SHD3_k127_856105_5 Lon protease (S16) C-terminal proteolytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 305.0
SHD3_k127_856105_6 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000004603 251.0
SHD3_k127_856105_7 transcription factor binding - - - 0.00000000000000000000000000000000000000000004131 181.0
SHD3_k127_856105_8 Matrixin - - - 0.0000000000000000000000000000000000004028 155.0
SHD3_k127_856105_9 Thioredoxin - - - 0.000000000000000000000000000000000006491 141.0
SHD3_k127_909579_0 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006878 324.0
SHD3_k127_909579_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000002514 171.0
SHD3_k127_909579_2 Belongs to the Pirin family K06911 - - 0.0000000000738 68.0
SHD3_k127_912051_0 LOR SDH bifunctional enzyme conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 608.0
SHD3_k127_912051_1 COG2266 GTP adenosylcobinamide-phosphate guanylyltransferase K19712 - 2.7.7.62 0.0000000151 61.0
SHD3_k127_922363_0 Transport of potassium into the cell K03549 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 450.0
SHD3_k127_922363_1 Pas domain - - - 0.000000000000000000000000000000000000000006342 164.0
SHD3_k127_922363_2 PFAM ATP-binding region ATPase domain protein - - - 0.000000007295 58.0
SHD3_k127_927302_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 539.0
SHD3_k127_927302_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 459.0
SHD3_k127_927302_2 Putative adhesin - - - 0.0000004094 57.0
SHD3_k127_934415_0 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 561.0
SHD3_k127_934415_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005208 528.0
SHD3_k127_934415_2 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 434.0
SHD3_k127_934415_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.0000000000000000000000000007303 117.0
SHD3_k127_934415_4 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749,K04757 - 2.7.11.1 0.000000000000001832 80.0