One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1431.0
SYD2_k127_1081721_1
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K00937
-
2.7.4.1
0.0
1307.0
SYD2_k127_1081721_10
flagellar motor switch protein
K02416
-
-
4.32e-215
670.0
SYD2_k127_1081721_11
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03601
-
3.1.11.6
5.84e-215
672.0
SYD2_k127_1081721_12
phosphorelay sensor kinase activity
-
-
-
2.324e-213
670.0
SYD2_k127_1081721_13
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
8.799e-206
642.0
SYD2_k127_1081721_14
Histidine kinase
-
-
-
1.163e-203
642.0
SYD2_k127_1081721_15
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
COG0402 Cytosine deaminase and related metal-dependent
K20810
-
3.5.4.40
5.082e-255
787.0
SYD2_k127_1081721_50
dihydroneopterin aldolase
K01633
-
1.13.11.81,4.1.2.25,5.1.99.8
0.0000000000000000000000000000000000000000006092
165.0
SYD2_k127_1081721_51
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K02834
-
-
0.000000000000000000000000000000000000008714
149.0
SYD2_k127_1081721_52
nucleic-acid-binding protein implicated in transcription termination
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.00000000000000000000000000000000000002433
144.0
SYD2_k127_1410742_33
-
-
-
-
0.0000000000000000000000000000000000006005
143.0
SYD2_k127_1410742_34
Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K02654
-
3.4.23.43
0.0000000000000000000000000000000001449
141.0
SYD2_k127_1410742_36
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.0000000000000000000000000000146
119.0
SYD2_k127_1410742_37
-
-
-
-
0.0000000000000000000000000269
113.0
SYD2_k127_1410742_38
-
-
-
-
0.000000000000000000000004139
117.0
SYD2_k127_1410742_39
Putative Tad-like Flp pilus-assembly
-
-
-
0.0000000000001243
84.0
SYD2_k127_1410742_4
AAA domain
-
-
-
5.473e-239
763.0
SYD2_k127_1410742_40
Flp pilus assembly protein RcpC/CpaB
K02279
-
-
0.00000000004949
73.0
SYD2_k127_1410742_42
Type II secretion system (T2SS), protein F
K12511
-
-
0.0000000392
63.0
SYD2_k127_1410742_43
Type II secretion system (T2SS), protein F
K12510
-
-
0.00000006755
63.0
SYD2_k127_1410742_44
Flp Fap pilin component
K02651
-
-
0.0000002875
54.0
SYD2_k127_1410742_45
COG0457 FOG TPR repeat
-
-
-
0.000002867
58.0
SYD2_k127_1410742_46
TadE-like protein
-
-
-
0.00001309
53.0
SYD2_k127_1410742_5
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
-
-
-
1.653e-220
688.0
SYD2_k127_1410742_6
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
2.694e-219
685.0
SYD2_k127_1410742_7
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01000
-
2.7.8.13
3.448e-212
661.0
SYD2_k127_1410742_8
Phospholipase D. Active site motifs.
K06131
-
-
1.654e-207
653.0
SYD2_k127_1410742_9
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1590.0
SYD2_k127_1734760_1
phosphomannomutase
K15778
-
5.4.2.2,5.4.2.8
2.968e-278
859.0
SYD2_k127_1734760_10
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K00133
-
1.2.1.11
3.178e-205
641.0
SYD2_k127_1734760_11
Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1067.0
SYD2_k127_2087248_1
ATPase related to phosphate starvation-inducible protein PhoH
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
K01462
-
3.5.1.88
0.00000000000000000000000000000000000000000004036
162.0
SYD2_k127_2087248_3
ATP synthase
K02412
-
3.6.3.14
2.66e-254
787.0
SYD2_k127_2087248_4
Cysteine desulfurase
K04487
-
2.8.1.7
5.348e-254
785.0
SYD2_k127_2087248_5
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
2.882e-268
828.0
SYD2_k127_2403_1
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K15726
-
-
0.0
1770.0
SYD2_k127_259715_1
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
K03495
-
-
0.0
1163.0
SYD2_k127_259715_10
pyruvate ferredoxin oxidoreductase
K00170
-
1.2.7.1
1.063e-213
663.0
SYD2_k127_259715_11
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K03639
-
4.1.99.22
1.342e-202
632.0
SYD2_k127_259715_12
ubiquinol cytochrome c oxidoreductase, cytochrome c1
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
Belongs to the bacterial ribosomal protein bL36 family
K02919
-
-
0.0000000000000005039
77.0
SYD2_k127_259715_47
-
-
-
-
0.0000000000001243
75.0
SYD2_k127_259715_5
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
3.522e-269
829.0
SYD2_k127_259715_6
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PFAM Glyoxalase bleomycin resistance protein dioxygenase
-
-
-
0.00000000000000000000000000000000000000000218
160.0
SYD2_k127_3166955_34
Redox-active disulfide protein
-
-
-
0.00000000000000000000000000000000000000964
145.0
SYD2_k127_3166955_36
-
-
-
-
0.0000000003842
66.0
SYD2_k127_3166955_37
cell redox homeostasis
K12057
-
-
0.0000001884
58.0
SYD2_k127_3166955_38
-
-
-
-
0.0000005097
53.0
SYD2_k127_3166955_4
Thiol disulfide interchange protein
K04084
-
1.8.1.8
2.048e-254
797.0
SYD2_k127_3166955_5
Oxidoreductase
K00174
-
1.2.7.11,1.2.7.3
8.455e-251
775.0
SYD2_k127_3166955_6
Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K03893
-
-
2.795e-244
758.0
SYD2_k127_3166955_7
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
1.199e-242
752.0
SYD2_k127_3166955_8
COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component
K09014
-
-
1.272e-227
706.0
SYD2_k127_3166955_9
ABC-type transport system involved in lipoprotein release permease component
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K00764
-
2.4.2.14
7.887e-293
899.0
SYD2_k127_3308162_30
Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate
K00215
-
1.17.1.8
0.000000000000000000000000000000000001383
138.0
SYD2_k127_3308162_31
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
K03116
-
-
0.0000000000000000000000000000002338
125.0
SYD2_k127_3308162_32
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1444.0
SYD2_k127_3422621_1
ATP citrate synthase
K15230
-
2.3.3.8
0.0
1192.0
SYD2_k127_3422621_10
integral membrane protein
-
-
-
3.308e-197
620.0
SYD2_k127_3422621_11
Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
K00820
-
2.6.1.16
0.0
1113.0
SYD2_k127_3422621_3
diguanylate cyclase
-
-
-
0.0
1043.0
SYD2_k127_3422621_4
Sodium/hydrogen exchanger family
-
-
-
0.0
1007.0
SYD2_k127_3422621_5
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K03147
-
4.1.99.17
5.512e-297
912.0
SYD2_k127_3422621_6
Belongs to the succinate malate CoA ligase beta subunit family
K15231
-
2.3.3.8
8.206e-294
901.0
SYD2_k127_3422621_7
GGDEF domain
-
-
-
2.748e-280
871.0
SYD2_k127_3422621_8
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
K03593
-
-
2.039e-237
740.0
SYD2_k127_3422621_9
Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K18285
-
2.5.1.120
1.496e-220
685.0
SYD2_k127_361269_0
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K01876
-
6.1.1.12
0.0
1185.0
SYD2_k127_361269_1
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0
1136.0
SYD2_k127_361269_10
protein involved in exopolysaccharide biosynthesis
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
1.031e-247
766.0
SYD2_k127_361269_6
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
K00773
-
2.4.2.29
4.285e-237
734.0
SYD2_k127_361269_7
Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily
K13747
-
4.1.1.96
6.868e-228
710.0
SYD2_k127_361269_8
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
TamB, inner membrane protein subunit of TAM complex
K09800
-
-
0.0
1428.0
SYD2_k127_4006526_1
COG4775 Outer membrane protein protective antigen OMA87
K07278
-
-
4.708e-305
941.0
SYD2_k127_4006526_2
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Belongs to the class-I aminoacyl-tRNA synthetase family
K01883
-
6.1.1.16
3.562e-286
881.0
SYD2_k127_4078203_4
ABC transporter
K11085
-
-
1.409e-284
883.0
SYD2_k127_4078203_5
Flagellar Assembly Protein A
-
-
-
2.091e-283
882.0
SYD2_k127_4078203_6
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
8.871e-287
883.0
SYD2_k127_4079860_4
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01939
-
6.3.4.4
6.436e-271
834.0
SYD2_k127_4079860_5
molybdopterin biosynthesis
K03750
-
2.10.1.1
1.178e-238
741.0
SYD2_k127_4079860_6
transporter
-
-
-
1.666e-235
733.0
SYD2_k127_4079860_7
Belongs to the CarA family
K01956
-
6.3.5.5
2.48e-229
712.0
SYD2_k127_4079860_8
Aminotransferase
-
-
-
3.325e-215
671.0
SYD2_k127_4079860_9
C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Belongs to the bacterial ribosomal protein bS21 family
K02970
-
-
0.000000000000000000000000000000000004537
137.0
SYD2_k127_4091896_0
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K03723
-
-
0.0
1859.0
SYD2_k127_4091896_1
Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0
1628.0
SYD2_k127_4091896_10
folylpolyglutamate synthase
K11754
-
6.3.2.12,6.3.2.17
7.537e-209
653.0
SYD2_k127_4091896_11
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.0000000000000000000000000000000000000000007412
158.0
SYD2_k127_4091896_33
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K00937
-
2.7.4.1
0.000000000000000000000000000000000000000008416
153.0
SYD2_k127_4091896_34
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
1.501e-285
882.0
SYD2_k127_4091896_5
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
2.454e-259
802.0
SYD2_k127_4091896_6
Diguanylate cyclase
-
-
-
1.144e-248
775.0
SYD2_k127_4091896_7
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K00557,K03212,K03215
-
2.1.1.189,2.1.1.190,2.1.1.35
4.281e-229
711.0
SYD2_k127_4091896_8
3-deoxy-d-manno-octulosonic-acid transferase
K02527
-
2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15
2.313e-213
666.0
SYD2_k127_4091896_9
apolipoprotein N-acyltransferase
K03820
-
-
1.54e-212
665.0
SYD2_k127_4170443_0
Belongs to the CarB family
K01955
-
6.3.5.5
0.0
2068.0
SYD2_k127_4170443_1
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.0
1432.0
SYD2_k127_4170443_10
outer membrane porin, OprD family
-
-
-
6.538e-227
709.0
SYD2_k127_4170443_11
rod shape-determining protein mreB
K03569
-
-
4.107e-213
665.0
SYD2_k127_4170443_12
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K09765
-
1.17.99.6
1.31e-199
627.0
SYD2_k127_4170443_13
Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
0.0
1088.0
SYD2_k127_4170443_30
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K14393
-
-
0.0
1018.0
SYD2_k127_4170443_5
flagellar hook-associated protein
K02396
-
-
6.327e-304
941.0
SYD2_k127_4170443_6
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
1.577e-262
811.0
SYD2_k127_4170443_7
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
5.248e-252
779.0
SYD2_k127_4170443_8
Glutathionylspermidine synthase
-
-
-
1.12e-245
764.0
SYD2_k127_4170443_9
Histidine kinase
-
-
-
1.941e-227
710.0
SYD2_k127_4224408_0
Glutamate synthase
K00265
-
1.4.1.13,1.4.1.14
0.0
2768.0
SYD2_k127_4224408_1
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
K03701
-
-
0.0
1817.0
SYD2_k127_4224408_10
Putative glycosyl hydrolase domain
-
-
-
2.365e-250
776.0
SYD2_k127_4224408_11
methyl-accepting chemotaxis protein
-
-
-
2.808e-233
727.0
SYD2_k127_4224408_12
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
5.927e-231
717.0
SYD2_k127_4224408_13
Belongs to the DEAD box helicase family
-
-
-
9.87e-228
710.0
SYD2_k127_4224408_14
ATP-dependent DNA helicase RecQ
K03654
-
3.6.4.12
2.79e-218
682.0
SYD2_k127_4224408_15
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
K00557
-
2.1.1.35
3.035e-204
639.0
SYD2_k127_4224408_16
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01338
-
3.4.21.53
0.0
1482.0
SYD2_k127_4303203_10
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
1.063e-297
917.0
SYD2_k127_4303203_11
MlaD protein
K02067
-
-
2.045e-277
856.0
SYD2_k127_4303203_12
COG1055 Na H antiporter NhaD and related arsenite
-
-
-
5.474e-274
845.0
SYD2_k127_4303203_13
Catalyzes the oxidation of L-aspartate to iminoaspartate
K00278
-
1.4.3.16
9.143e-272
841.0
SYD2_k127_4303203_14
Belongs to the GARS family
K01945
-
6.3.4.13
5.598e-271
834.0
SYD2_k127_4303203_15
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
1.573e-267
825.0
SYD2_k127_4303203_16
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
2.006e-265
821.0
SYD2_k127_4303203_17
HI0933 family
K07007
-
-
1.62e-245
760.0
SYD2_k127_4303203_18
Belongs to the phosphoglycerate kinase family
K00927
-
2.7.2.3
6.64e-245
760.0
SYD2_k127_4303203_19
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)
K11784
-
1.21.98.1
3.73e-224
695.0
SYD2_k127_4303203_2
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.0
1312.0
SYD2_k127_4303203_20
Participates in both transcription termination and antitermination
K02600
-
-
5.892e-223
694.0
SYD2_k127_4303203_21
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit
K00341
-
1.6.5.3
0.0
1193.0
SYD2_k127_4303203_40
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
0.0
1023.0
SYD2_k127_4303203_60
-
-
-
-
0.0000000000000000000000000000000000000000002917
160.0
SYD2_k127_4303203_61
Peptidase M16
K07263
-
-
0.000000000000000000000000000000000000003066
162.0
SYD2_k127_4303203_62
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
K09710
-
-
0.0000000000000000000000001656
109.0
SYD2_k127_4303203_63
RDD family
-
-
-
0.00000000000000000000004471
105.0
SYD2_k127_4303203_64
-
-
-
-
0.000000000000000000001231
100.0
SYD2_k127_4303203_7
Catalyzes the synthesis of GMP from XMP
K01951
-
6.3.5.2
0.0
1002.0
SYD2_k127_4303203_8
ATP-dependent DNA helicase
K03655
-
3.6.4.12
1.698e-320
989.0
SYD2_k127_4303203_9
COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)
K00342
-
1.6.5.3
4.086e-313
961.0
SYD2_k127_4321928_0
Domain of Unknown Function (DUF748)
-
-
-
0.0
1586.0
SYD2_k127_4321928_1
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00525
-
1.17.4.1
0.0
1580.0
SYD2_k127_4321928_10
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
4.818e-217
674.0
SYD2_k127_4321928_11
tRNA nucleotidyltransferase poly(A) polymerase
K00974
-
2.7.7.72
3.076e-213
672.0
SYD2_k127_4321928_12
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.484e-209
659.0
SYD2_k127_4321928_13
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
2.251e-208
650.0
SYD2_k127_4321928_14
Part of the ABC transporter complex PstSACB involved in phosphate import
K02040
-
-
7.141e-207
645.0
SYD2_k127_4321928_15
Belongs to the UPF0324 family
-
-
-
8.499e-203
635.0
SYD2_k127_4321928_16
Arginosuccinate synthase
K00566
-
2.8.1.13
1.079e-199
623.0
SYD2_k127_4321928_17
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.000000000000000000000000000000000000408
148.0
SYD2_k127_4321928_4
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication
K02316
-
-
0.0
1009.0
SYD2_k127_4321928_41
-
-
-
-
0.000000003807
64.0
SYD2_k127_4321928_42
Resistance to Hg(2 ) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0)
K00520
-
1.16.1.1
0.00000000563
60.0
SYD2_k127_4321928_5
Phospholipid glycerol acyltransferase
-
-
-
0.0
1008.0
SYD2_k127_4321928_6
Mg chelatase-related protein
K07391
-
-
2.645e-284
878.0
SYD2_k127_4321928_7
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
2.148e-283
871.0
SYD2_k127_4321928_8
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
1.422e-263
815.0
SYD2_k127_4321928_9
Histidine kinase
-
-
-
4.249e-258
800.0
SYD2_k127_4351875_0
COG0058 Glucan phosphorylase
K00688
-
2.4.1.1
2.729e-300
927.0
SYD2_k127_4351875_1
Belongs to the glycosyl hydrolase 57 family
K16149
-
2.4.1.18
1.225e-296
917.0
SYD2_k127_4351875_2
Synthesizes alpha-1,4-glucan chains using ADP-glucose
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1729.0
SYD2_k127_4380239_1
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1325.0
SYD2_k127_4380239_10
The M ring may be actively involved in energy transduction
K02409
-
-
1.404e-315
972.0
SYD2_k127_4380239_100
ATPase, P-type (transporting), HAD superfamily, subfamily IC
K17686
-
3.6.3.54
0.0000006333
59.0
SYD2_k127_4380239_11
Domain of unknown function (DUF4105)
-
-
-
6.776e-304
942.0
SYD2_k127_4380239_12
Pilus assembly protein
-
-
-
4.385e-290
895.0
SYD2_k127_4380239_13
Type II and III secretion system protein
K02453
-
-
6.963e-276
855.0
SYD2_k127_4380239_14
phosphate-selective porin O and P
-
-
-
3.899e-268
830.0
SYD2_k127_4380239_15
O-acetylhomoserine sulfhydrylase
K01740
-
2.5.1.49
6.367e-248
767.0
SYD2_k127_4380239_16
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
1.126e-246
763.0
SYD2_k127_4380239_17
N-acetylmuramoyl-L-alanine amidase
K01448
-
3.5.1.28
1.247e-245
768.0
SYD2_k127_4380239_18
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K01875
-
6.1.1.11
8.301e-245
759.0
SYD2_k127_4380239_19
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
2.081e-239
742.0
SYD2_k127_4380239_2
ATP-dependent CLP protease ATP-binding subunit
K03694
-
-
0.0
1306.0
SYD2_k127_4380239_20
Type II secretion system
K02455,K12278
-
-
1.465e-232
723.0
SYD2_k127_4380239_21
twitching motility protein
K02669
-
-
2.989e-227
707.0
SYD2_k127_4380239_22
2-nitropropane dioxygenase
K00459
-
1.13.12.16
1.204e-225
700.0
SYD2_k127_4380239_23
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
1.553e-222
692.0
SYD2_k127_4380239_24
-
-
-
-
7.138e-222
694.0
SYD2_k127_4380239_25
C-terminal domain of metallo-carboxypeptidase
-
-
-
5.597e-220
688.0
SYD2_k127_4380239_26
Chorismate mutase prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
2.318e-215
671.0
SYD2_k127_4380239_27
Sulfatase-modifying factor enzyme 1
-
-
-
2.091e-209
669.0
SYD2_k127_4380239_28
EAL domain
-
-
-
1.764e-207
650.0
SYD2_k127_4380239_29
ABC-type transport system involved in resistance to organic solvents permease component
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01662
-
2.2.1.7
0.0
1115.0
SYD2_k127_4380239_60
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Belongs to the multicopper oxidase YfiH RL5 family
K05810
-
-
0.00000000000000000000000000000000000000000000143
174.0
SYD2_k127_4380239_94
Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
K03060
-
2.7.7.6
0.0000000000000000000000000000000001449
133.0
SYD2_k127_4380239_95
-
-
-
-
0.0000000000000000000000000000003698
123.0
SYD2_k127_4380239_97
-
-
-
-
0.00000000000000002745
85.0
SYD2_k127_4380239_99
Helix-hairpin-helix motif
K02237
-
-
0.000000006951
56.0
SYD2_k127_4432974_0
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
K01007
-
2.7.9.2
0.0
1360.0
SYD2_k127_4432974_1
Highly conserved protein containing a thioredoxin domain
K06888
-
-
0.0
1016.0
SYD2_k127_4432974_10
YcaO cyclodehydratase, ATP-ad Mg2+-binding
K09136
-
-
1.046e-204
642.0
SYD2_k127_4432974_11
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily
K01465
-
3.5.2.3
3.686e-199
626.0
SYD2_k127_4432974_12
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
K03551
-
3.6.4.12
3.377e-199
622.0
SYD2_k127_4446568_14
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04066
-
-
1.246e-316
976.0
SYD2_k127_4608638_1
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
GO:0003674,GO:0005488,GO:0005515,GO:0042802
3.6.4.12
2.094e-291
897.0
SYD2_k127_4608638_2
Competence protein
K02238
-
-
2.714e-236
734.0
SYD2_k127_4608638_3
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0000000000000000000000000000000000000000008165
156.0
SYD2_k127_5184181_3
COG1459 Type II secretory pathway, component PulF
K02455
-
-
1.611e-228
711.0
SYD2_k127_5184181_4
Belongs to the SEDS family
K03588
-
-
1.275e-226
706.0
SYD2_k127_5184181_5
Pilus assembly protein
-
-
-
3.943e-219
689.0
SYD2_k127_5184181_6
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K02836
-
-
1.124e-207
651.0
SYD2_k127_5184181_7
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
-
-
-
5.824e-316
970.0
SYD2_k127_5220732_11
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
7.526e-293
901.0
SYD2_k127_5220732_12
Belongs to the UPF0061 (SELO) family
-
-
-
1.225e-286
883.0
SYD2_k127_5220732_13
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
5.823e-286
880.0
SYD2_k127_5220732_14
argininosuccinate lyase
K01755
-
4.3.2.1
9.477e-277
855.0
SYD2_k127_5220732_15
potassium channel protein
K10716
-
-
6.938e-271
840.0
SYD2_k127_5220732_16
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00833
-
2.6.1.62
3.591e-269
830.0
SYD2_k127_5220732_17
Flagellar Assembly Protein A
-
-
-
3.233e-256
802.0
SYD2_k127_5220732_18
HD domain
-
-
-
2.868e-254
791.0
SYD2_k127_5220732_19
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00800
-
2.5.1.19
7.561e-250
774.0
SYD2_k127_5220732_2
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K02492
-
1.2.1.70
2.181e-225
704.0
SYD2_k127_5220732_24
ABC transporter
K02004
-
-
7.998e-225
701.0
SYD2_k127_5220732_25
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
7.704e-224
696.0
SYD2_k127_5220732_26
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
K01881
-
6.1.1.15
0.0
1078.0
SYD2_k127_5220732_50
redox protein regulator of disulfide bond formation
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.0000000000000000007337
87.0
SYD2_k127_5220732_75
protein affecting phage T7 exclusion by the F plasmid
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K00123
-
1.17.1.9
0.0
1312.0
SYD2_k127_5469912_1
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
1.989e-242
752.0
SYD2_k127_5469912_10
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.000000000000000000000000000000000000000005731
154.0
SYD2_k127_5469912_19
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K02954
-
-
0.000000000000000000000000000000002125
128.0
SYD2_k127_5469912_2
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01610
-
4.1.1.49
0.0
1025.0
SYD2_k127_5519419_1
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.0000000000000000001603
88.0
SYD2_k127_5522264_29
Fe2 transport system protein A
K04758
-
-
0.0000000000001773
73.0
SYD2_k127_5522264_3
chemotaxis protein
K03407
-
2.7.13.3
0.0
1035.0
SYD2_k127_5522264_4
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K03628
-
-
1.111e-279
861.0
SYD2_k127_5522264_5
DNA recombination protein
K09760
-
-
2.039e-263
814.0
SYD2_k127_5522264_6
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K02343
-
2.7.7.7
6.021e-258
799.0
SYD2_k127_5522264_7
Belongs to the peptidase M24B family
K01262
-
3.4.11.9
1.275e-216
679.0
SYD2_k127_5522264_8
Histidine kinase
K02484
-
2.7.13.3
9.52e-210
659.0
SYD2_k127_5522264_9
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1603.0
SYD2_k127_6130570_1
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
K03702
-
-
0.0
1247.0
SYD2_k127_6130570_5
Hypothetical glycosyl hydrolase family 13
K11931
-
-
0.0
1180.0
SYD2_k127_6130570_6
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0
1019.0
SYD2_k127_6130570_7
glutamine synthetase
K01915
-
6.3.1.2
0.0
1000.0
SYD2_k127_6130570_8
peptidase U32 family
K08303
-
-
1.095e-278
857.0
SYD2_k127_6130570_9
Glycosyl transferase family 21
K11936
-
-
1.068e-277
856.0
SYD2_k127_6203045_0
Cytochrome c oxidase accessory protein
-
-
-
5.077e-292
900.0
SYD2_k127_6203045_1
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
3.619e-267
823.0
SYD2_k127_6203045_10
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RNA-binding protein homologous to eukaryotic snRNP
-
-
-
2.231e-243
756.0
SYD2_k127_6203045_4
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K02835
-
-
1.448e-219
683.0
SYD2_k127_6203045_5
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
K00099
-
1.1.1.267
1.834e-197
619.0
SYD2_k127_6203045_8
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Belongs to the short-chain dehydrogenases reductases (SDR) family
-
-
-
0.0000000000000000000000000000000000000000005035
167.0
SYD2_k127_6248745_33
-
-
-
-
0.000000000000000000000000000000000001927
139.0
SYD2_k127_6248745_34
Histidine kinase
K02484
-
2.7.13.3
0.00000000000000000000009606
111.0
SYD2_k127_6248745_35
PFAM purine or other phosphorylase family 1
-
-
-
0.0000000000000000000005277
106.0
SYD2_k127_6248745_36
Involved in the binding of tRNA to the ribosomes
K02946
-
-
0.0000000000000000002121
90.0
SYD2_k127_6248745_37
-
-
-
-
0.00000000000000009904
81.0
SYD2_k127_6248745_38
PFAM AMMECR1 domain protein
K09141
-
-
0.00000000000001166
78.0
SYD2_k127_6248745_39
-
-
-
-
0.000003989
49.0
SYD2_k127_6248745_4
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
2.405e-255
792.0
SYD2_k127_6248745_5
Sugar (and other) transporter
-
-
-
1.186e-240
746.0
SYD2_k127_6248745_6
Polysaccharide biosynthesis protein
-
-
-
1.285e-227
709.0
SYD2_k127_6248745_7
COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.0
1260.0
SYD2_k127_6387011_1
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1184.0
SYD2_k127_6387011_10
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.0000000000000000000000000003659
114.0
SYD2_k127_6387011_16
Nucleoside-specific channel-forming protein, Tsx
-
-
-
0.000000000000001054
86.0
SYD2_k127_6387011_19
Binds directly to 16S ribosomal RNA
K02968
-
-
0.0007362
51.0
SYD2_k127_6387011_2
Putative diguanylate phosphodiesterase
-
-
-
0.0
1039.0
SYD2_k127_6387011_3
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
1.032e-279
861.0
SYD2_k127_6387011_4
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
1.267e-221
691.0
SYD2_k127_6387011_5
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
Belongs to the heme-copper respiratory oxidase family
-
-
-
1.431e-266
828.0
SYD2_k127_6527258_40
Iron-binding zinc finger CDGSH type
-
-
-
0.00000000000000000000000000000000000000000003
161.0
SYD2_k127_6527258_41
Acetyltransferase (GNAT) domain
-
-
-
0.00000000000000000000000000000000000000000004957
168.0
SYD2_k127_6527258_42
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.00000000000000000000000000000000000002827
158.0
SYD2_k127_6527258_43
diguanylate cyclase
-
-
-
0.000000000000000000000000000000000003285
160.0
SYD2_k127_6527258_46
Histidine kinase
-
-
-
0.00000000000000000000000000001802
138.0
SYD2_k127_6527258_47
Domain of unknown function (DUF4919)
-
-
-
0.00000000000000000000000000007355
124.0
SYD2_k127_6527258_48
-
-
-
-
0.0000000000000000000000000002805
124.0
SYD2_k127_6527258_49
Cytochrome C oxidase, cbb3-type, subunit III
-
-
-
0.0000000000000000004981
90.0
SYD2_k127_6527258_5
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.000000000000000000000000000000000000001755
147.0
SYD2_k127_6776783_23
Protein of unknown function (DUF1653)
-
-
-
0.0000000000000000000000000000000000003658
139.0
SYD2_k127_6776783_25
S4 domain
K14761
-
-
0.00000000000000000000000000001088
118.0
SYD2_k127_6776783_26
Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
K03596
-
-
0.0
1146.0
SYD2_k127_7289021_2
Nitroreductase family
-
-
-
4.504e-245
764.0
SYD2_k127_7289021_3
COG0471 Di- and tricarboxylate
K03319
-
-
9.185e-244
759.0
SYD2_k127_7289021_4
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides
signal transduction protein containing a membrane domain an EAL and a GGDEF domain
-
-
-
1.801e-285
890.0
SYD2_k127_7292289_9
mechanosensitive ion channel
-
-
-
7.95e-285
882.0
SYD2_k127_7322228_0
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
0.0
1219.0
SYD2_k127_7322228_1
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
1.519e-249
775.0
SYD2_k127_7322228_10
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
K03217
-
-
1.304e-314
967.0
SYD2_k127_75398_1
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
2.534e-295
909.0
SYD2_k127_75398_10
Involved in the biosynthesis of porphyrin-containing compound
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
Could be involved in insertion of integral membrane proteins into the membrane
-
-
-
0.00000000000000000001369
95.0
SYD2_k127_75398_36
Belongs to the ClpA ClpB family
K03694,K03695
-
-
0.00000000000000000002038
90.0
SYD2_k127_75398_37
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.000000000000000000137
88.0
SYD2_k127_75398_4
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
2.615e-255
791.0
SYD2_k127_75398_5
Belongs to the aspartokinase family
K00928
-
2.7.2.4
9.012e-247
764.0
SYD2_k127_75398_6
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K00053
-
1.1.1.86
4.856e-220
684.0
SYD2_k127_75398_7
Na H antiporter
-
-
-
1.126e-214
670.0
SYD2_k127_75398_8
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K07568
-
2.4.99.17
1.752e-208
649.0
SYD2_k127_75398_9
dihydropteroate synthase
K00796
-
2.5.1.15
2.589e-195
614.0
SYD2_k127_7571707_0
Glycyl-tRNA synthetase beta subunit
K01879
-
6.1.1.14
0.0
1131.0
SYD2_k127_7571707_1
Catalyzes the ferrous insertion into protoporphyrin IX
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
K00088
-
1.1.1.205
6.639e-306
938.0
SYD2_k127_7645382_20
Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.000000000000000000000000003612
111.0
SYD2_k127_7645382_31
Copper binding periplasmic protein CusF
K07810
-
-
0.000000000000000000000000003666
114.0
SYD2_k127_7645382_32
-
-
-
-
0.00000000000000000000000002206
113.0
SYD2_k127_7645382_34
-
-
-
-
0.00000000353
58.0
SYD2_k127_7645382_4
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
4.104e-272
839.0
SYD2_k127_7645382_5
o-acetylhomoserine
K01740
-
2.5.1.49
6.685e-258
797.0
SYD2_k127_7645382_6
Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K00641
-
2.3.1.31
5.501e-235
728.0
SYD2_k127_7645382_7
Belongs to the CinA family
K03743
-
3.5.1.42
5.695e-208
651.0
SYD2_k127_7645382_8
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Dinitrogenase iron-molybdenum cofactor biosynthesis protein
K02596
-
-
0.00000000000000000001831
90.0
SYD2_k127_873949_0
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K02111
-
3.6.3.14
1.466e-315
968.0
SYD2_k127_873949_1
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K02112
-
3.6.3.14
1.812e-299
921.0
SYD2_k127_873949_10
Major Facilitator
-
-
-
4.703e-206
646.0
SYD2_k127_873949_11
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K03595
-
-
0.0000000000000000000000000000000001032
134.0
SYD2_k127_873949_4
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
2.636e-236
736.0
SYD2_k127_873949_5
Involved in the TonB-independent uptake of proteins
K03641
-
-
6.497e-222
692.0
SYD2_k127_873949_6
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01439
-
3.5.1.18
8.831e-212
662.0
SYD2_k127_908172_0
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1078.0
SYD2_k127_908172_1
lytic murein transglycosylase
K08309
-
-
1.489e-298
921.0
SYD2_k127_908172_2
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
5.218e-259
801.0
SYD2_k127_908172_3
COG0474 Cation transport ATPase
K01537
-
3.6.3.8
4.401e-228
712.0
SYD2_k127_908172_4
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K00648
-
2.3.1.180
1.296e-195
613.0
SYD2_k127_910196_11
GTPase that plays an essential role in the late steps of ribosome biogenesis
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
5.048e-244
755.0
SYD2_k127_910196_41
Prokaryotic metallothionein
K06950
-
-
0.000000000000000000000000000000262
124.0
SYD2_k127_910196_42
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.000000000000000000000008454
100.0
SYD2_k127_910196_43
Chain length determinant protein
-
-
-
0.00000002767
64.0
SYD2_k127_910196_5
Belongs to the agmatine deiminase family
-
-
-
1.309e-213
665.0
SYD2_k127_910196_6
Cytochrome c554 and c-prime
-
-
-
4.165e-213
666.0
SYD2_k127_910196_7
ADP-L-glycero-D-manno-heptose-6-epimerase
K03274
-
5.1.3.20
1.297e-209
653.0
SYD2_k127_910196_8
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
