Belongs to the class-I aminoacyl-tRNA synthetase family
K01869
-
6.1.1.4
0.0
1426.0
SYD2_k127_1075082_1
DNA helicase
K03657
-
3.6.4.12
0.0
1231.0
SYD2_k127_1075082_10
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K03072
-
-
3.333e-265
824.0
SYD2_k127_1075082_3
Diguanylate cyclase
-
-
-
1.921e-238
746.0
SYD2_k127_1075082_4
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB
Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane
K03980
-
-
1.606e-250
778.0
SYD2_k127_1115527_4
Belongs to the peptidase M16 family
-
-
-
1.37e-233
728.0
SYD2_k127_1115527_5
ABC transporter
K11085
-
-
4.381e-233
734.0
SYD2_k127_1115527_6
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
K03581
-
3.1.11.5
0.0
1127.0
SYD2_k127_1152209_10
peptidase U32 family
K08303
-
-
1.039e-259
803.0
SYD2_k127_1152209_11
Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K03272
-
2.7.1.167,2.7.7.70
4.696e-254
789.0
SYD2_k127_1152209_12
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
1.409e-231
719.0
SYD2_k127_1152209_13
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K03526
-
1.17.7.1,1.17.7.3
4.88e-215
669.0
SYD2_k127_1152209_14
Competence protein
K02238
-
-
3.788e-207
650.0
SYD2_k127_1152209_15
lipopolysaccharide core region biosynthetic process
-
-
-
3.742e-201
633.0
SYD2_k127_1152209_16
Belongs to the agmatine deiminase family
-
-
-
7.142e-201
628.0
SYD2_k127_1152209_17
ADP-L-glycero-D-manno-heptose-6-epimerase
K03274
-
5.1.3.20
1.724e-200
626.0
SYD2_k127_1152209_18
Belongs to the ALAD family
K01698
-
4.2.1.24
3.05e-197
617.0
SYD2_k127_1152209_19
peptidase M23
-
-
-
1.27e-196
619.0
SYD2_k127_1152209_2
TonB dependent receptor
K02014
-
-
0.0
1066.0
SYD2_k127_1152209_20
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Belongs to the bacterial ribosomal protein bL32 family
K02911
-
-
0.000000000000000000000005274
101.0
SYD2_k127_1152209_68
Prokaryotic N-terminal methylation motif
-
-
-
0.00000000008304
68.0
SYD2_k127_1152209_7
it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins
K02314
GO:0003674,GO:0005488,GO:0005515,GO:0042802
3.6.4.12
8.051e-285
878.0
SYD2_k127_1152209_8
Glycolate oxidase subunit
K00104
-
1.1.3.15
6.264e-284
874.0
SYD2_k127_1152209_9
GTPase that plays an essential role in the late steps of ribosome biogenesis
K03977
-
-
1.001e-281
870.0
SYD2_k127_118848_0
This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation
Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01872
-
6.1.1.7
0.0
1568.0
SYD2_k127_1431423_20
Belongs to the flagella basal body rod proteins family
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Belongs to the bacterial ribosomal protein bL33 family
K02913
-
-
0.00000000000000000000000007298
106.0
SYD2_k127_1431423_3
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K02355
-
-
0.0
1333.0
SYD2_k127_1431423_30
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation
K03073
-
-
0.00000000000000000012
89.0
SYD2_k127_1431423_4
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01649
-
2.3.3.13
0.0
1056.0
SYD2_k127_1431423_5
Cell division protein FtsI penicillin-binding protein
K03587
-
3.4.16.4
0.0
1029.0
SYD2_k127_1431423_6
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K02358
-
-
4.497e-245
758.0
SYD2_k127_1431423_7
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
K02836
-
-
1.673e-226
703.0
SYD2_k127_1431423_8
Belongs to the SEDS family
K03588
-
-
1.46e-211
664.0
SYD2_k127_1431423_9
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01866
-
6.1.1.1
0.00000000000000000000003507
99.0
SYD2_k127_1466213_0
Belongs to the ClpA ClpB family
K03694,K03695
-
-
0.0
1502.0
SYD2_k127_1466213_1
transporter of a GTP-driven Fe(2 ) uptake system
K04759
-
-
0.0
1170.0
SYD2_k127_1466213_10
ADP-ribosylglycohydrolase
-
-
-
5.127e-198
620.0
SYD2_k127_1466213_11
Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme
Could be involved in insertion of integral membrane proteins into the membrane
-
-
-
0.00000000000000000000000000000001093
129.0
SYD2_k127_1466213_46
-
-
-
-
0.0000000000000000000000000001822
114.0
SYD2_k127_1466213_47
-
-
-
-
0.000000000000000000003089
94.0
SYD2_k127_1466213_48
Belongs to the bacterial ribosomal protein bL34 family
K02914
-
-
0.0000000000000000002675
88.0
SYD2_k127_1466213_49
iron ion homeostasis
K04758
-
-
0.00000000000000004616
83.0
SYD2_k127_1466213_5
PFAM EAL domain
-
-
-
5.879e-261
816.0
SYD2_k127_1466213_50
involved in DNA uptake
K04096
-
-
0.000000000001365
70.0
SYD2_k127_1466213_6
chemotaxis protein
K03407
-
2.7.13.3
3.238e-242
774.0
SYD2_k127_1466213_7
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K03650
-
-
1.225e-221
693.0
SYD2_k127_1466213_8
DNA recombination protein
K09760
-
-
1.647e-219
687.0
SYD2_k127_1466213_9
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K03832
-
-
0.000000000000000000000000006073
119.0
SYD2_k127_1581654_0
damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Belongs to the heme-copper respiratory oxidase family
K00404
-
1.9.3.1
2.366e-316
969.0
SYD2_k127_2160832_1
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01139
-
2.7.6.5,3.1.7.2
0.0
1148.0
SYD2_k127_2329093_1
PFAM peptidase M3A and M3B thimet oligopeptidase F
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K04042
-
2.3.1.157,2.7.7.23
5.868e-235
732.0
SYD2_k127_2754390_4
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA)
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine
K01586
-
4.1.1.20
6.939e-236
732.0
SYD2_k127_2766266_6
O-acetylhomoserine sulfhydrylase
K01740
-
2.5.1.49
1.756e-222
694.0
SYD2_k127_2766266_7
twitching motility protein
K02669
-
-
1.385e-216
676.0
SYD2_k127_2766266_8
Chorismate mutase prephenate dehydratase
K14170
-
4.2.1.51,5.4.99.5
1.066e-209
654.0
SYD2_k127_2766266_9
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K00817
-
2.6.1.9
3.668e-205
642.0
SYD2_k127_2843634_0
An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K12574
-
-
0.0
1237.0
SYD2_k127_2843634_1
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01868
-
6.1.1.3
0.0
1176.0
SYD2_k127_2843634_10
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K03431
-
5.4.2.10
5.976e-262
811.0
SYD2_k127_2843634_30
Binds directly to 16S ribosomal RNA
K02968
-
-
0.000000000000000000000000000000000000004061
149.0
SYD2_k127_2843634_31
Belongs to the bacterial ribosomal protein bL35 family
K02916
-
-
0.00000000000000000000000000001539
118.0
SYD2_k127_2843634_35
chemotaxis
K03408
-
-
0.00000000000000000000004537
104.0
SYD2_k127_2843634_36
Chemoreceptor zinc-binding domain
K03408
-
-
0.00000000000000005396
90.0
SYD2_k127_2843634_4
Putative diguanylate phosphodiesterase
-
-
-
3.306e-245
781.0
SYD2_k127_2843634_5
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
K06941
-
2.1.1.192
3.185e-217
676.0
SYD2_k127_2843634_6
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
1.022e-266
822.0
SYD2_k127_2955896_1
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K03639
-
4.1.99.22
6.889e-197
616.0
SYD2_k127_2955896_2
ubiquinol cytochrome c oxidoreductase, cytochrome c1
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K00412
-
-
7.408e-280
859.0
SYD2_k127_3215298_1
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K03639
-
4.1.99.22
5.217e-206
641.0
SYD2_k127_3215298_2
ubiquinol cytochrome c oxidoreductase, cytochrome c1
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K03296
-
-
0.0
1553.0
SYD2_k127_3498899_1
COG0474 Cation transport ATPase
K01537
-
3.6.3.8
0.0
1252.0
SYD2_k127_3498899_10
Biotin carboxylase
K01959,K01961
-
6.3.4.14,6.4.1.1,6.4.1.2
4.964e-255
792.0
SYD2_k127_3498899_11
NMT1-like family
K02051,K15576
-
-
7.154e-255
788.0
SYD2_k127_3498899_12
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01925
-
6.3.2.9
2.293e-247
767.0
SYD2_k127_3498899_13
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP
K09458
-
2.3.1.179
1.486e-246
763.0
SYD2_k127_3498899_14
Chemotaxis phosphatase CheX
-
-
-
3.319e-241
751.0
SYD2_k127_3498899_15
Belongs to the peptidase S41A family
K03797
-
3.4.21.102
2.837e-234
730.0
SYD2_k127_3498899_16
Nitroreductase family
-
-
-
5.101e-226
711.0
SYD2_k127_3498899_17
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K00147
-
1.2.1.41
6.777e-222
692.0
SYD2_k127_3498899_18
PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
-
-
-
1.112e-217
683.0
SYD2_k127_3498899_19
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K00620
-
2.3.1.1,2.3.1.35
8.457e-217
677.0
SYD2_k127_3498899_2
Heat shock 70 kDa protein
K04043
-
-
0.0
1156.0
SYD2_k127_3498899_20
Potassium uptake protein
K03498
-
-
2.626e-212
667.0
SYD2_k127_3498899_21
COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member
-
-
-
7.928e-209
655.0
SYD2_k127_3498899_22
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01952
-
6.3.5.3
0.00000000000000000000000000000000000001419
144.0
SYD2_k127_3498899_76
Carrier of the growing fatty acid chain in fatty acid biosynthesis
K02078
-
-
0.000000000000000000000000000000000007985
137.0
SYD2_k127_3498899_77
-
-
-
-
0.00000000000000000000000000000001012
147.0
SYD2_k127_3498899_79
Belongs to the bacterial ribosomal protein bL28 family
K02902
-
-
0.000000000000000000000000000009929
119.0
SYD2_k127_3498899_8
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K15633
-
5.4.2.12
5.036e-281
868.0
SYD2_k127_3498899_80
COG1309 Transcriptional regulator
-
-
-
0.00000000000000000000000000001118
125.0
SYD2_k127_3498899_81
-
-
-
-
0.00000000000000000000000000001231
122.0
SYD2_k127_3498899_82
S4 domain
K14761
-
-
0.000000000000000000000000008898
110.0
SYD2_k127_3498899_83
Protein of unknown function (DUF1653)
-
-
-
0.0000000000000000000000008939
105.0
SYD2_k127_3498899_84
-
-
-
-
0.000000000000000000000001453
106.0
SYD2_k127_3498899_85
Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates
K01937
-
6.3.4.2
0.0
1046.0
SYD2_k127_3507427_10
Belongs to the GSP D family
K02453,K12282
-
-
2.301e-236
738.0
SYD2_k127_3507427_11
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K00526
-
1.17.4.1
2.01e-214
666.0
SYD2_k127_3507427_12
Single-stranded-DNA-specific exonuclease (RecJ)
K07462
-
-
7.852e-214
676.0
SYD2_k127_3507427_13
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ATPase related to phosphate starvation-inducible protein PhoH
K07175
-
-
8.925e-280
864.0
SYD2_k127_3507427_30
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02470
-
5.99.1.3
0.0
1465.0
SYD2_k127_3665857_1
Mitochondrial degradasome RNA helicase subunit C terminal
K17675
-
3.6.4.13
0.0
1428.0
SYD2_k127_3665857_10
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01756
-
4.3.2.2
4.022e-262
809.0
SYD2_k127_3665857_11
Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis
K01689
-
4.2.1.11
6.448e-260
802.0
SYD2_k127_3665857_12
COG4775 Outer membrane protein protective antigen OMA87
it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K02313
-
-
1.454e-235
733.0
SYD2_k127_3665857_16
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08289
-
2.1.2.2
8.325e-226
703.0
SYD2_k127_3665857_17
Belongs to the dGTPase family. Type 2 subfamily
K01129
-
3.1.5.1
6.281e-215
670.0
SYD2_k127_3665857_18
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
-
-
-
1.207e-208
657.0
SYD2_k127_3665857_2
GTP-binding protein
K06207
-
-
0.0
1181.0
SYD2_k127_3665857_20
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
K02232
-
6.3.5.10
2.293e-204
644.0
SYD2_k127_3665857_21
Methyl-accepting chemotaxis protein
K03406
-
-
1.307e-199
636.0
SYD2_k127_3665857_22
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria
K02338
-
2.7.7.7
5.586e-197
617.0
SYD2_k127_3665857_23
Flagellar basal body protein
K02390
-
-
1.851e-196
621.0
SYD2_k127_3665857_24
Phosphoribosylformylglycinamidine cyclo-ligase
K01933
-
6.3.3.1
7.122e-196
613.0
SYD2_k127_3665857_25
Part of the ABC transporter complex PstSACB involved in phosphate import
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Belongs to the bacterial ribosomal protein bS21 family
K02970
-
-
0.000000000000000000000000000000000004537
137.0
SYD2_k127_3665857_79
Uncharacterized conserved protein (DUF2249)
-
-
-
0.000000000000000000000000000008944
120.0
SYD2_k127_3665857_8
Cytochrome c oxidase accessory protein
-
-
-
4.753e-275
850.0
SYD2_k127_3665857_80
Domain of unknown function (DUF309)
K09763
-
-
0.00000000000000000000000000007188
119.0
SYD2_k127_3665857_81
-
-
-
-
0.0000000000000000000000000614
109.0
SYD2_k127_3665857_83
-
-
-
-
0.0000000000000000000003424
104.0
SYD2_k127_3665857_84
-
-
-
-
0.000000000000000000004511
94.0
SYD2_k127_3665857_9
phosphate transporter
K03306
-
-
7.688e-263
816.0
SYD2_k127_3752267_0
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00343
-
1.6.5.3
5.8e-276
854.0
SYD2_k127_3752267_12
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K00333
-
1.6.5.3
4.967e-264
813.0
SYD2_k127_3752267_13
Belongs to the aldehyde dehydrogenase family
-
-
-
1.939e-261
810.0
SYD2_k127_3752267_14
Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K06168
-
2.8.4.3
3.831e-260
804.0
SYD2_k127_3752267_15
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12
K14441
-
2.8.4.4
2.916e-254
787.0
SYD2_k127_3752267_16
Protein of unknown function (DUF3373)
-
-
-
5.855e-242
757.0
SYD2_k127_3752267_17
The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently
K03076
-
-
2.471e-241
749.0
SYD2_k127_3752267_18
Participates in both transcription termination and antitermination
COGs COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase
K15022
-
1.17.1.10
0.0
1336.0
SYD2_k127_3752267_20
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K02357
-
-
9.979e-202
631.0
SYD2_k127_3752267_21
aldo keto reductase
-
-
-
3.147e-200
626.0
SYD2_k127_3752267_22
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K00337
-
1.6.5.3
3.048e-199
622.0
SYD2_k127_3752267_23
Nucleotidyltransferase DNA polymerase involved in DNA repair
K02346
-
2.7.7.7
4.342e-194
615.0
SYD2_k127_3752267_24
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit
K00341
-
1.6.5.3
7.352e-314
970.0
SYD2_k127_3752267_70
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine
COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M)
K00342
-
1.6.5.3
1.649e-291
899.0
SYD2_k127_3752267_80
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K02961
-
-
0.00000000000000000000000000000000000000000001375
162.0
SYD2_k127_3752267_92
-
-
-
-
0.000000000000000000000000000000000000000001538
156.0
SYD2_k127_3752267_93
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K02518
-
-
0.00000000000000000000000000000000000000001079
153.0
SYD2_k127_3752267_94
Belongs to the UPF0102 family
K07460
-
-
0.00000000000000000000000000000000000000001696
154.0
SYD2_k127_3752267_95
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K02895
-
-
0.000000000000000000000000000000000000001631
148.0
SYD2_k127_3752267_96
-
-
-
-
0.0000000000000000000000000000000000009205
144.0
SYD2_k127_3752267_97
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K02954
-
-
0.000000000000000000000000000000007548
127.0
SYD2_k127_3752267_98
putative NADH-ubiquinone oxidoreductase chain E
K00334
-
1.6.5.3
0.0000000000000000000000000000003609
123.0
SYD2_k127_3752267_99
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane
K03070
-
-
0.0
1465.0
SYD2_k127_4048696_1
Isocitrate dehydrogenase
K00031
-
1.1.1.42
0.0
1185.0
SYD2_k127_4048696_10
COGs COG0069 Glutamate synthase domain 2
-
-
-
2.962e-242
760.0
SYD2_k127_4048696_11
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit
K01903
-
6.2.1.5
1.129e-237
736.0
SYD2_k127_4048696_12
Belongs to the citrate synthase family
K01647
-
2.3.3.1
2.093e-236
735.0
SYD2_k127_4048696_13
Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K03893
-
-
6.941e-234
728.0
SYD2_k127_4048696_14
Aminotransferase
K00812
-
2.6.1.1
2.222e-229
713.0
SYD2_k127_4048696_15
histidyl-tRNA synthetase
K01892
-
6.1.1.21
1.774e-228
711.0
SYD2_k127_4048696_16
Protein of unknown function (DUF2867)
-
-
-
9.037e-222
702.0
SYD2_k127_4048696_17
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K01754
-
4.3.1.19
7.807e-218
680.0
SYD2_k127_4048696_18
ABC-type transport system involved in lipoprotein release permease component
K02004
-
-
3.649e-208
652.0
SYD2_k127_4048696_19
Oxidoreductase
K00174
-
1.2.7.11,1.2.7.3
2.989e-196
616.0
SYD2_k127_4048696_2
arginine decarboxylase
K01585
-
4.1.1.19
0.0
1173.0
SYD2_k127_4048696_20
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
glyoxalase bleomycin resistance protein dioxygenase
K01759
-
4.4.1.5
0.00000000000000000000000000000000000000000007418
165.0
SYD2_k127_4048696_76
Heavy-metal-associated domain
-
-
-
0.0000000000000000000000000000000000001047
143.0
SYD2_k127_4048696_77
Redox-active disulfide protein
-
-
-
0.0000000000000000000000000000000000102
136.0
SYD2_k127_4048696_78
-
-
-
-
0.000000000000000000000000000000001123
130.0
SYD2_k127_4048696_79
Rhodanese Homology Domain
-
-
-
0.00000000000000000000000000199
116.0
SYD2_k127_4048696_8
WD40 repeats
-
-
-
4.994e-250
790.0
SYD2_k127_4048696_80
COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
-
-
-
0.00000000000000000000000001006
115.0
SYD2_k127_4048696_82
-
-
-
-
0.0000000000000001447
87.0
SYD2_k127_4048696_84
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K00943
-
2.7.4.9
0.000000000000003248
83.0
SYD2_k127_4048696_85
cell redox homeostasis
-
-
-
0.000000000002489
71.0
SYD2_k127_4048696_88
Glycine zipper 2TM domain
-
-
-
0.00001308
52.0
SYD2_k127_4048696_9
phosphate acetyltransferase
K00625,K13788
-
2.3.1.8
8.709e-245
775.0
SYD2_k127_4048696_90
-
-
-
-
0.00003723
46.0
SYD2_k127_4048696_91
Belongs to the 'phage' integrase family
K03111
-
-
0.00004567
47.0
SYD2_k127_4048696_92
PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K02397
-
-
1.504e-222
715.0
SYD2_k127_4139790_12
ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins
K03686
-
-
2.463e-222
692.0
SYD2_k127_4139790_13
Putative glycosyl hydrolase domain
-
-
-
3.972e-217
679.0
SYD2_k127_4139790_14
COG0513 Superfamily II DNA and RNA
K11927
-
3.6.4.13
7.189e-214
672.0
SYD2_k127_4139790_15
twitching motility protein
K02669
-
-
3.368e-206
644.0
SYD2_k127_4139790_16
Belongs to the DEAD box helicase family
K05591
-
3.6.4.13
4.33e-204
643.0
SYD2_k127_4139790_17
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family
K00134
-
1.2.1.12
2.193e-202
631.0
SYD2_k127_4139790_18
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K02335
-
2.7.7.7
0.0
1489.0
SYD2_k127_4139790_30
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02435
-
6.3.5.6,6.3.5.7
0.0000000000000000000000000000000000000001242
152.0
SYD2_k127_4139790_53
Belongs to the 'phage' integrase family
K03111
-
-
0.00003934
46.0
SYD2_k127_4139790_6
phospho-2-dehydro-3-deoxyheptonate aldolase
K01626
-
2.5.1.54
6.505e-284
874.0
SYD2_k127_4139790_7
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction
K00962
-
2.7.7.8
0.0
1252.0
SYD2_k127_420348_10
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)
Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04744
-
-
1.414e-304
948.0
SYD2_k127_420348_4
ATP-dependent DNA helicase
K03655
-
3.6.4.12
3.052e-290
900.0
SYD2_k127_420348_5
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
K03703
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
5.57e-287
891.0
SYD2_k127_420348_6
Belongs to the GARS family
K01945
-
6.3.4.13
4.306e-259
800.0
SYD2_k127_420348_7
MlaD protein
K02067
-
-
3.207e-252
783.0
SYD2_k127_420348_8
Catalyzes the oxidation of L-aspartate to iminoaspartate
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K02469
-
5.99.1.3
0.0
1550.0
SYD2_k127_4410191_1
Ammonium Transporter
K03320
-
-
4.411e-233
727.0
SYD2_k127_4410191_2
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01599
-
4.1.1.37
3.649e-221
686.0
SYD2_k127_4410191_3
Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01255
-
3.4.11.1
1.028e-260
808.0
SYD2_k127_461670_10
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)
Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ATPase, P-type (transporting), HAD superfamily, subfamily IC
K01535,K01537
-
3.6.3.6,3.6.3.8
7.48e-313
979.0
SYD2_k127_4647452_10
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily
K13747
-
4.1.1.96
3.736e-228
709.0
SYD2_k127_4647452_4
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
-
-
-
0.0
2192.0
SYD2_k127_5104125_1
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K00990
-
2.7.7.59
0.0
1468.0
SYD2_k127_5104125_10
Sulfite dehydrogenase (Cytochrome) subunit SorA apoprotein
K07147
-
-
4.946e-244
756.0
SYD2_k127_5104125_11
Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K00013
-
1.1.1.23
1.922e-242
752.0
SYD2_k127_5104125_12
Belongs to the aspartokinase family
K00928
-
2.7.2.4
3.076e-236
733.0
SYD2_k127_5104125_13
chemotaxis protein
K03406
-
-
3.779e-235
737.0
SYD2_k127_5104125_14
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP
K03593
-
-
1.197e-232
722.0
SYD2_k127_5104125_15
sulfate adenylyltransferase
K00958
-
2.7.7.4
4.767e-218
681.0
SYD2_k127_5104125_16
Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K18285
-
2.5.1.120
1.87e-214
667.0
SYD2_k127_5104125_17
fructose-bisphosphate aldolase
K01624
-
4.1.2.13
4.051e-213
664.0
SYD2_k127_5104125_18
Na H antiporter
-
-
-
6.439e-201
631.0
SYD2_k127_5104125_19
Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)
forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K03147
-
4.1.99.17
1.177e-291
898.0
SYD2_k127_5104125_7
Histidine kinase
K20972
-
-
8.689e-268
837.0
SYD2_k127_5104125_8
ATP citrate lyase citrate-binding
-
-
-
5.748e-263
813.0
SYD2_k127_5104125_9
Belongs to the pyruvate kinase family
K00873
-
2.7.1.40
7.27e-250
780.0
SYD2_k127_5257334_0
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K00367,K00372,K08356
-
1.20.2.1,1.20.9.1,1.7.7.2
0.0
1346.0
SYD2_k127_5257334_1
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K02434
-
6.3.5.6,6.3.5.7
2.301e-281
867.0
SYD2_k127_5257334_16
argininosuccinate lyase
K01755
-
4.3.2.1
9.502e-263
813.0
SYD2_k127_5257334_17
COG2223 Nitrate nitrite transporter
K02575
-
-
4.797e-262
809.0
SYD2_k127_5257334_18
Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring
K03590
-
-
5.185e-255
792.0
SYD2_k127_5257334_19
Belongs to the MurCDEF family
K01924
-
6.3.2.8
1.483e-254
788.0
SYD2_k127_5257334_2
ABC transporter, ATP-binding protein
K15738
-
-
0.0
1178.0
SYD2_k127_5257334_20
TonB-dependent receptor
-
-
-
3.375e-249
786.0
SYD2_k127_5257334_21
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate
K00800
-
2.5.1.19
3.021e-231
721.0
SYD2_k127_5257334_22
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K00833
-
2.6.1.62
2.042e-218
684.0
SYD2_k127_5257334_23
ABC transporter
K02004
-
-
4.405e-214
669.0
SYD2_k127_5257334_24
Peptidase M48
K06013
-
3.4.24.84
1.36e-213
670.0
SYD2_k127_5257334_25
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K03531
-
-
5.103e-212
662.0
SYD2_k127_5257334_26
potassium channel protein
K10716
-
-
2.573e-209
662.0
SYD2_k127_5257334_27
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01889
-
6.1.1.20
2.404e-206
644.0
SYD2_k127_5257334_28
peptidylprolyl isomerase
K03770
-
5.2.1.8
8.817e-200
634.0
SYD2_k127_5257334_29
Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01972
-
6.5.1.2
0.0
1161.0
SYD2_k127_5257334_30
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS
Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
-
-
-
0.000000000000000000003419
99.0
SYD2_k127_5257334_83
-
-
-
-
0.00000000000000000001844
94.0
SYD2_k127_5257334_84
-
-
-
-
0.0000000000000000009603
87.0
SYD2_k127_5257334_85
-
-
-
-
0.000000000000008006
86.0
SYD2_k127_5257334_86
-
-
-
-
0.000000000001686
76.0
SYD2_k127_5257334_89
COG3030 Protein affecting phage T7 exclusion by the F plasmid
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K00058
-
1.1.1.399,1.1.1.95
1.02e-321
988.0
SYD2_k127_548019_0
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase
K07478
-
-
8.632e-220
685.0
SYD2_k127_5483195_4
Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K17758,K17759
-
4.2.1.136,5.1.99.6
3.921e-206
651.0
SYD2_k127_5483195_5
Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family
first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K02519
-
-
0.0
1394.0
SYD2_k127_580588_1
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K00937
-
2.7.4.1
0.0
1279.0
SYD2_k127_580588_10
von Willebrand factor, type A
K07114
-
-
1.751e-199
633.0
SYD2_k127_580588_11
Major facilitator superfamily
K03762
-
-
4.402e-199
627.0
SYD2_k127_580588_12
COG0402 Cytosine deaminase and related metal-dependent
K20810
-
3.5.4.40
5.235e-198
623.0
SYD2_k127_580588_13
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K03517
-
2.5.1.72
4.897e-195
610.0
SYD2_k127_580588_14
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03601
-
3.1.11.6
9.818e-195
615.0
SYD2_k127_580588_15
Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components
K03106
-
3.6.5.4
8.378e-250
775.0
SYD2_k127_580588_30
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Belongs to the bacterial ribosomal protein bS16 family
K02959
-
-
0.0000000000000000000000000000000000000000000512
160.0
SYD2_k127_580588_55
cheY-homologous receiver domain
-
-
-
0.0000000000000000000000000000000000000000002475
160.0
SYD2_k127_580588_56
COG1214 Inactive homolog of metal-dependent proteases
-
-
-
0.0000000000000000000000000000000000000000005761
162.0
SYD2_k127_580588_57
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K02834
-
-
0.00000000000000000000000000000000000000802
148.0
SYD2_k127_580588_58
dihydroneopterin aldolase
K01633
-
1.13.11.81,4.1.2.25,5.1.99.8
0.00000000000000000000000000000000001153
141.0
SYD2_k127_580588_59
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
nucleic-acid-binding protein implicated in transcription termination
-
-
-
0.0000000000000855
74.0
SYD2_k127_580588_61
Oxygen tolerance
-
-
-
0.0000000000005754
80.0
SYD2_k127_580588_62
Helix-turn-helix domain
-
-
-
0.000000007808
61.0
SYD2_k127_580588_64
Belongs to the UPF0109 family
K06960
-
-
0.000000713
53.0
SYD2_k127_580588_7
Guanosine pentaphosphate phosphohydrolase
K01524
-
3.6.1.11,3.6.1.40
1.954e-215
679.0
SYD2_k127_580588_8
flagellar motor switch protein
K02416
-
-
4.159e-205
641.0
SYD2_k127_580588_9
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34
K00566
-
2.8.1.13
6.956e-202
631.0
SYD2_k127_5844361_0
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth
K03086
-
-
0.0
1124.0
SYD2_k127_5984539_1
Glutamate-1-semialdehyde aminotransferase
K01845
-
5.4.3.8
2.44e-255
790.0
SYD2_k127_5984539_10
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
K00052
-
1.1.1.85
1.232e-218
679.0
SYD2_k127_5984539_3
Belongs to the flagella basal body rod proteins family
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01895
-
6.2.1.1
0.0
1260.0
SYD2_k127_6067247_10
outer membrane porin, OprD family
-
-
-
4.053e-224
700.0
SYD2_k127_6067247_11
rod shape-determining protein mreB
K03569
-
-
1.666e-211
659.0
SYD2_k127_6067247_12
Sugar (and other) transporter
-
-
-
1.922e-203
641.0
SYD2_k127_6067247_13
Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K09765
-
1.17.99.6
1.245e-195
613.0
SYD2_k127_6067247_14
Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs
Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
K03455
-
-
9.422e-284
878.0
SYD2_k127_6067247_40
Histidine kinase
-
-
-
0.0000000000000000000000000000000000000000001084
165.0
SYD2_k127_6067247_41
Rod shape-determining protein MreC
K03570
-
-
0.0000000000000000000000000000000000000000001135
169.0
SYD2_k127_6067247_43
MOSC domain
-
-
-
0.00000000000000000000000002923
109.0
SYD2_k127_6067247_44
Anti-sigma-28 factor, FlgM
-
-
-
0.0000000000000000000000004742
106.0
SYD2_k127_6067247_45
-
-
-
-
0.00000000207
63.0
SYD2_k127_6067247_5
signal-transduction protein containing cAMP-binding and CBS domains
K07182
-
-
3.96e-281
874.0
SYD2_k127_6067247_6
flagellar hook-associated protein
K02396
-
-
4.864e-271
846.0
SYD2_k127_6067247_7
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K03544
-
-
8.838e-238
738.0
SYD2_k127_6067247_8
Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K00790
-
2.5.1.7
1.039e-237
741.0
SYD2_k127_6067247_9
Glutathionylspermidine synthase
-
-
-
1.206e-232
722.0
SYD2_k127_6097901_0
COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit
K14086
-
-
1.062e-273
853.0
SYD2_k127_6097901_1
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions
K04077
-
-
1.096e-252
781.0
SYD2_k127_6097901_2
Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04078
GO:0003674,GO:0005488,GO:0005515,GO:0042802
-
0.00000000000000000000000000000000000149
139.0
SYD2_k127_622861_0
amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01870
-
6.1.1.5
0.0
1770.0
SYD2_k127_622861_1
amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner
K01873
-
6.1.1.9
0.0
1685.0
SYD2_k127_622861_10
o-acetylhomoserine
K01740
-
2.5.1.49
1.671e-252
782.0
SYD2_k127_622861_11
Pilus assembly protein
-
-
-
2.453e-252
786.0
SYD2_k127_622861_12
Belongs to the DNA mismatch repair MutS family
K03555
-
-
2.77e-240
760.0
SYD2_k127_622861_13
Belongs to the argininosuccinate synthase family. Type 1 subfamily
K01940
-
6.3.4.5
3.651e-232
724.0
SYD2_k127_622861_14
this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K03667
-
-
7.019e-225
702.0
SYD2_k127_622861_15
Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K00641
-
2.3.1.31
3.543e-224
696.0
SYD2_k127_622861_16
Type II secretion system
K02455,K12278
-
-
9.314e-222
692.0
SYD2_k127_622861_17
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K02454,K02652
-
-
0.0
1039.0
SYD2_k127_622861_40
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides
K03602
-
3.1.11.6
0.0000000000000000000000002017
106.0
SYD2_k127_622861_86
Copper binding periplasmic protein CusF
K07810
-
-
0.000000000000000000005536
96.0
SYD2_k127_622861_87
-
-
-
-
0.000000000000000000009682
91.0
SYD2_k127_622861_89
Anaphase-promoting complex, cyclosome, subunit 3
-
-
-
0.000000000000001395
86.0
SYD2_k127_622861_9
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)
K02433
-
6.3.5.6,6.3.5.7
3.652e-261
812.0
SYD2_k127_6327416_0
Diguanylate cyclase
-
-
-
0.0
1261.0
SYD2_k127_6327416_1
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01874
-
6.1.1.10
0.0
1194.0
SYD2_k127_7408926_1
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Flagellar basal body rod FlgEFG protein C-terminal
K02388
-
-
0.00000000000000000000000000006643
118.0
SYD2_k127_7408926_49
GGDEF domain
-
-
-
0.000000000000000000000000001105
126.0
SYD2_k127_7408926_5
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01885
-
6.1.1.17
5.31e-245
760.0
SYD2_k127_7408926_50
-
-
-
-
0.000000000000000006613
84.0
SYD2_k127_7408926_6
Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA
K00674
-
2.3.1.117
9.942e-226
702.0
SYD2_k127_7408926_7
May be involved in recombinational repair of damaged DNA
K03631
-
-
4.45e-220
692.0
SYD2_k127_7408926_8
PFAM Methyl-accepting chemotaxis protein (MCP) signaling domain
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K00789
-
2.5.1.6
0.00000000000000000000000008567
106.0
SYD2_k127_7792564_2
Alginate O-acetylation protein
-
-
-
3.72e-196
621.0
SYD2_k127_7792564_20
Methyltransferase domain
-
-
-
0.0000000000000000000000004407
113.0
SYD2_k127_7792564_21
methyltransferase
K16648
-
-
0.000000000000000000000002176
113.0
SYD2_k127_7792564_3
epimerase dehydratase family
K01784,K08679
-
5.1.3.2,5.1.3.6
1.364e-195
613.0
SYD2_k127_7792564_4
Belongs to the UDP-N-acetylglucosamine 2-epimerase family
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K00615
-
2.2.1.1
0.0
1177.0
SYD2_k127_7849441_1
Aminotransferase
K14261
-
-
1.87e-259
800.0
SYD2_k127_7849441_10
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01928
-
6.3.2.13
1.696e-243
756.0
SYD2_k127_7849441_20
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Domain in cystathionine beta-synthase and other proteins.
-
-
-
0.0000000000000000000000000000000000000002165
154.0
SYD2_k127_86503_52
Chorismate mutase
K04782
-
4.2.99.21
0.0000000000000000000000000000000000000004005
151.0
SYD2_k127_86503_53
Belongs to the P(II) protein family
-
-
-
0.000000000000000000000000000000000002576
140.0
SYD2_k127_86503_54
Protein of unknown function, DUF255
-
-
-
0.00000000000000000000000000000000003218
138.0
SYD2_k127_86503_55
Thioredoxin-like domain
K03981
-
5.3.4.1
0.00000000000000000000000000000001264
136.0
SYD2_k127_86503_56
cytochrome c class I
-
-
-
0.000000000000000000000000000000137
127.0
SYD2_k127_86503_58
-
-
-
-
0.0000000000000000000000004446
106.0
SYD2_k127_86503_59
-
-
-
-
0.000000000000000000002547
94.0
SYD2_k127_86503_6
Sulfate permease
K03321
-
-
1.299e-266
829.0
SYD2_k127_86503_7
Radical SAM
-
-
-
2.306e-264
820.0
SYD2_k127_86503_8
Thiol disulfide interchange protein
K04084
-
1.8.1.8
7.497e-249
781.0
SYD2_k127_86503_9
HI0933-like protein
K07007
-
-
8.266e-234
727.0
SYD2_k127_923278_0
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
