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Overview

ID MAG03880
Name TH1_bin.6
Sample SMP0100
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family Methanospirillaceae
Genus UBA9949
Species
Assembly information
Completeness (%) 85.88
Contamination (%) 0.36
GC content (%) 53.0
N50 (bp) 13,453
Genome size (bp) 1,529,793

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1635

Gene name Description KEGG GOs EC E-value Score Sequence
TH1_k127_1071847_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.031e-245 769.0
TH1_k127_1071847_1 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 364.0
TH1_k127_1071847_2 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 348.0
TH1_k127_1071847_3 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 344.0
TH1_k127_1071847_4 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 295.0
TH1_k127_1071847_5 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004742 261.0
TH1_k127_1071847_6 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000007811 173.0
TH1_k127_1071847_7 metallopeptidase activity - - - 0.00000000000000000000000002318 116.0
TH1_k127_1071847_8 - - - - 0.000000002946 59.0
TH1_k127_1154504_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 550.0
TH1_k127_1154504_1 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 409.0
TH1_k127_1154504_2 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008703 291.0
TH1_k127_1154504_3 DNA modification - - - 0.0000000000000000007201 91.0
TH1_k127_1291763_0 Domain of unknown function (DUF1848) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 370.0
TH1_k127_1291763_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 362.0
TH1_k127_1291763_2 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 334.0
TH1_k127_1291763_3 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 313.0
TH1_k127_1291763_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000007185 220.0
TH1_k127_1291763_5 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000004311 197.0
TH1_k127_1291763_6 COG1881 Phospholipid-binding protein K06910 - - 0.00000000000000000000000000000000000000000000004941 173.0
TH1_k127_1291763_7 - - - - 0.00000000000000000000000000000000000002256 151.0
TH1_k127_1291763_8 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.0000000000000000000000000000766 116.0
TH1_k127_1296332_0 CorA-like Mg2+ transporter protein K03284 GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 417.0
TH1_k127_1296332_1 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000007382 217.0
TH1_k127_1296332_2 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000007036 211.0
TH1_k127_1296332_3 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000000004239 140.0
TH1_k127_132033_0 AMP-binding enzyme - - - 1.838e-208 656.0
TH1_k127_132033_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000008205 263.0
TH1_k127_132033_2 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002096 245.0
TH1_k127_132033_3 COG2041 Sulfite oxidase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001931 248.0
TH1_k127_132033_4 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000000000000000000001584 107.0
TH1_k127_1450146_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006822 449.0
TH1_k127_1450146_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 349.0
TH1_k127_1450146_2 PHP-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 315.0
TH1_k127_1450146_3 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000004065 87.0
TH1_k127_1450146_4 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.00000000001411 69.0
TH1_k127_1471383_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.12e-231 724.0
TH1_k127_1471383_1 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 337.0
TH1_k127_1471383_2 Stage II sporulation protein M K06384 - - 0.0000000000000000000000000000000000000000000000000001965 190.0
TH1_k127_1471383_3 - - - - 0.000000005765 64.0
TH1_k127_1498023_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1409.0
TH1_k127_1498023_1 Proton-conducting membrane transporter K05568 - - 2.448e-217 685.0
TH1_k127_1498023_10 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.00000000000000000000000000000000000003707 145.0
TH1_k127_1498023_11 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.00000000000000000000000000000002542 130.0
TH1_k127_1498023_12 zinc finger, SWIM - - - 0.00000000000000000000000000000006371 128.0
TH1_k127_1498023_13 Multisubunit Na H antiporter, MnhF subunit K05570 - - 0.0000000000000000000002259 98.0
TH1_k127_1498023_14 Domain of unknown function (DUF4040) - - - 0.0000000000000000000008516 103.0
TH1_k127_1498023_15 Membrane bound hydrogenase - - - 0.000000000000000002016 89.0
TH1_k127_1498023_2 PFAM PUA domain K00390 - 1.8.4.10,1.8.4.8 5.613e-196 620.0
TH1_k127_1498023_3 NIF3 (NGG1p interacting factor 3) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002237 282.0
TH1_k127_1498023_4 Multisubunit Na H antiporter MnhE subunit K05569 - - 0.000000000000000000000000000000000000000000000000000000007627 203.0
TH1_k127_1498023_5 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000004384 201.0
TH1_k127_1498023_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000069 193.0
TH1_k127_1498023_7 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.0000000000000000000000000000000000000000000000773 173.0
TH1_k127_1498023_8 - - - - 0.00000000000000000000000000000000000001537 149.0
TH1_k127_1498023_9 - - - - 0.00000000000000000000000000000000000002964 154.0
TH1_k127_1503090_0 AAA-like domain K06915 - - 1.649e-222 702.0
TH1_k127_1503090_1 SPFH Band 7 PHB domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 357.0
TH1_k127_1503090_2 PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 372.0
TH1_k127_1503090_3 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000007218 187.0
TH1_k127_1511151_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000437 500.0
TH1_k127_1511151_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 417.0
TH1_k127_1511151_2 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 330.0
TH1_k127_1511151_3 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 301.0
TH1_k127_1536449_0 Ferrous iron transport B domain protein K04759 - - 5.85e-226 716.0
TH1_k127_1536449_1 Helix-hairpin-helix domain K02347 - - 1.015e-195 625.0
TH1_k127_1536449_10 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000002483 199.0
TH1_k127_1536449_11 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000004171 164.0
TH1_k127_1536449_12 iron dependent repressor K03709,K04758 - - 0.00000000000000000000000000000000000007108 150.0
TH1_k127_1536449_13 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.0000000000000000000000000000002895 128.0
TH1_k127_1536449_14 Protein of unknown function (DUF357) K09728 - - 0.0000000000000000000000000002174 121.0
TH1_k127_1536449_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 497.0
TH1_k127_1536449_3 PFAM conserved K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009913 412.0
TH1_k127_1536449_4 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 404.0
TH1_k127_1536449_5 Papain family cysteine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 416.0
TH1_k127_1536449_6 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 339.0
TH1_k127_1536449_7 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 330.0
TH1_k127_1536449_8 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000001094 255.0
TH1_k127_1536449_9 Protein of unknown function (DUF541) K09807 - - 0.00000000000000000000000000000000000000000000000000000000004187 213.0
TH1_k127_1556320_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 1.612e-303 940.0
TH1_k127_1556320_1 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 329.0
TH1_k127_1556320_2 PFAM TspO MBR family K05770 - - 0.0000000000000000000000000000000000000000000004217 171.0
TH1_k127_1556320_3 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000001348 161.0
TH1_k127_1556320_4 ATPase activity K16786,K16787 - - 0.0000000000000000000000000000001966 129.0
TH1_k127_1556320_5 Protein of unknown function (DUF1722) - - - 0.0000000000001684 73.0
TH1_k127_1556320_6 helicase C-terminal domain protein - - - 0.00002914 51.0
TH1_k127_1556320_7 Protein of unknown function (DUF1722) - - - 0.00004851 50.0
TH1_k127_1592692_0 COG0784 FOG CheY-like receiver K01584 - 4.1.1.19 0.0 1163.0
TH1_k127_1592692_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.839e-264 822.0
TH1_k127_1592692_10 LOR SDH bifunctional enzyme conserved - - - 1.278e-198 627.0
TH1_k127_1592692_11 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 541.0
TH1_k127_1592692_12 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 531.0
TH1_k127_1592692_13 Pas domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 519.0
TH1_k127_1592692_14 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 480.0
TH1_k127_1592692_15 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 478.0
TH1_k127_1592692_16 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 474.0
TH1_k127_1592692_17 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 462.0
TH1_k127_1592692_18 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 459.0
TH1_k127_1592692_19 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 460.0
TH1_k127_1592692_2 PFAM amino acid permease-associated region K20265 - - 1.38e-226 710.0
TH1_k127_1592692_20 peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 455.0
TH1_k127_1592692_21 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 457.0
TH1_k127_1592692_22 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 442.0
TH1_k127_1592692_23 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 440.0
TH1_k127_1592692_24 archaeal coiled-coil protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 432.0
TH1_k127_1592692_25 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 428.0
TH1_k127_1592692_26 Domain of unknown function (DUF373) K08975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008648 433.0
TH1_k127_1592692_27 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 418.0
TH1_k127_1592692_28 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 412.0
TH1_k127_1592692_29 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 397.0
TH1_k127_1592692_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 2.488e-211 661.0
TH1_k127_1592692_30 Sulfide dehydrogenase (Flavoprotein) subunit SudB K00528,K02823 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 389.0
TH1_k127_1592692_31 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 364.0
TH1_k127_1592692_32 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 358.0
TH1_k127_1592692_33 Rhodanese Homology Domain K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 352.0
TH1_k127_1592692_34 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 346.0
TH1_k127_1592692_35 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 317.0
TH1_k127_1592692_36 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 312.0
TH1_k127_1592692_37 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 306.0
TH1_k127_1592692_38 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 294.0
TH1_k127_1592692_39 pyrroline-5-carboxylate reductase activity K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001933 273.0
TH1_k127_1592692_4 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 1.263e-205 651.0
TH1_k127_1592692_40 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001913 259.0
TH1_k127_1592692_41 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000764 259.0
TH1_k127_1592692_42 PFAM AMMECR1 domain protein K09141 - - 0.000000000000000000000000000000000000000000000000000000000000000000005224 244.0
TH1_k127_1592692_43 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000004684 233.0
TH1_k127_1592692_44 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000001815 223.0
TH1_k127_1592692_45 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000000000000000000000002957 220.0
TH1_k127_1592692_46 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215,K03546 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 0.000000000000000000000000000000000000000000000000000000005839 208.0
TH1_k127_1592692_47 - - - - 0.0000000000000000000000000000000000000000000000000000001113 210.0
TH1_k127_1592692_48 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000002911 195.0
TH1_k127_1592692_49 Helix-turn-helix domain protein K03627 - - 0.0000000000000000000000000000000000000000000000000005236 188.0
TH1_k127_1592692_5 PFAM PUA domain containing protein K07557 - 2.6.1.97 2.601e-205 652.0
TH1_k127_1592692_50 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.000000000000000000000000000000000000000000000000002616 189.0
TH1_k127_1592692_51 - - - - 0.00000000000000000000000000000000000000000000000004791 181.0
TH1_k127_1592692_52 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000000000000002275 156.0
TH1_k127_1592692_53 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000005851 159.0
TH1_k127_1592692_54 - - - - 0.00000000000000000000000000000000000001649 151.0
TH1_k127_1592692_55 DGC domain - - - 0.0000000000000000000000000000000000007985 146.0
TH1_k127_1592692_56 DGC domain - - - 0.000000000000000000000000000000000003207 141.0
TH1_k127_1592692_57 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000000000000000002876 134.0
TH1_k127_1592692_58 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.0000000000000000000000000000001259 129.0
TH1_k127_1592692_59 PFAM regulatory protein, ArsR K21903 - - 0.000000000000000000000000000002942 126.0
TH1_k127_1592692_6 PFAM peptidase U32 K08303 - - 3.954e-203 662.0
TH1_k127_1592692_60 - - - - 0.000000000000000000000000005753 116.0
TH1_k127_1592692_61 - - - - 0.000000000000000000000000049 110.0
TH1_k127_1592692_62 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000107 108.0
TH1_k127_1592692_63 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00000000000000000001176 92.0
TH1_k127_1592692_64 structural constituent of ribosome K02962 - - 0.00000000000000000001667 92.0
TH1_k127_1592692_65 DGC domain - - - 0.000000000000000008728 91.0
TH1_k127_1592692_66 - - - - 0.0000000000002048 71.0
TH1_k127_1592692_67 - - - - 0.00002399 50.0
TH1_k127_1592692_68 COGs COG0515 Serine threonine protein kinase - - - 0.00007011 54.0
TH1_k127_1592692_7 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 8.492e-202 633.0
TH1_k127_1592692_8 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 1.275e-201 634.0
TH1_k127_1592692_9 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 2.238e-199 631.0
TH1_k127_1615813_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0 1021.0
TH1_k127_1615813_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 604.0
TH1_k127_1615813_2 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 473.0
TH1_k127_1615813_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000001197 153.0
TH1_k127_163679_0 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 360.0
TH1_k127_163679_1 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 329.0
TH1_k127_163679_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 294.0
TH1_k127_163679_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.0000000000000000000000000000000000000000000000001119 179.0
TH1_k127_163679_4 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000003541 159.0
TH1_k127_1714750_0 Involved in regulation of DNA replication K10725 - - 1.191e-218 684.0
TH1_k127_1714750_1 PFAM Aminotransferase class I and II K10907 - - 3.422e-196 618.0
TH1_k127_1714750_10 Trm112p-like protein - - - 0.0000000000000000002912 89.0
TH1_k127_1714750_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 557.0
TH1_k127_1714750_3 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 550.0
TH1_k127_1714750_4 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 466.0
TH1_k127_1714750_5 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 359.0
TH1_k127_1714750_6 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000004321 242.0
TH1_k127_1714750_7 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000000000008395 228.0
TH1_k127_1714750_8 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000001995 203.0
TH1_k127_1714750_9 KEOPS complex Cgi121-like subunit K09119 - - 0.00000000000000000000000000000000000003442 151.0
TH1_k127_1722150_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 9.866e-205 645.0
TH1_k127_1722150_1 Glutaredoxin - - - 0.00000000000000002864 83.0
TH1_k127_1739412_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1084.0
TH1_k127_1739412_1 PFAM ferredoxin-dependent glutamate synthase - - - 1.719e-294 911.0
TH1_k127_1739412_10 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000000000000000000000000000000000000000004547 216.0
TH1_k127_1739412_11 Tellurite resistance protein TerB - - - 0.00000000000000000000000000000000000000000000000004579 181.0
TH1_k127_1739412_12 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000008365 121.0
TH1_k127_1739412_13 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000000001437 98.0
TH1_k127_1739412_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008015 512.0
TH1_k127_1739412_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 442.0
TH1_k127_1739412_4 4-Hydroxyphenylpyruvate dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 421.0
TH1_k127_1739412_5 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 408.0
TH1_k127_1739412_6 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005601 367.0
TH1_k127_1739412_7 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005737 292.0
TH1_k127_1739412_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008117 264.0
TH1_k127_1739412_9 Ferritin-like domain K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000000000000000000000001746 237.0
TH1_k127_1750618_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 505.0
TH1_k127_1750618_1 N-4 methylation of cytosine K00590 - 2.1.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 480.0
TH1_k127_180233_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 6.287e-219 683.0
TH1_k127_180233_1 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 340.0
TH1_k127_180233_2 PFAM NADP-dependent oxidoreductase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 297.0
TH1_k127_180233_3 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 293.0
TH1_k127_180233_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003095 274.0
TH1_k127_180233_5 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000000000000000005613 194.0
TH1_k127_180233_6 Fe-S-cluster oxidoreductase - - - 0.00000000000000000000000000000000000000000007626 164.0
TH1_k127_180233_7 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000177 112.0
TH1_k127_180233_8 - - - - 0.0000000000000001438 86.0
TH1_k127_1856499_0 DEAD DEAH box helicase domain protein K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 390.0
TH1_k127_1856499_1 Protein of unknown function (DUF2769) - - - 0.0000000000000000002604 92.0
TH1_k127_1871122_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 548.0
TH1_k127_1871122_1 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 537.0
TH1_k127_1871122_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 479.0
TH1_k127_1871122_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000005619 53.0
TH1_k127_1871696_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 417.0
TH1_k127_1871696_1 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 319.0
TH1_k127_1871696_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000001171 210.0
TH1_k127_1871696_3 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000001351 196.0
TH1_k127_1871696_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.00000000000000000000000000000000000000000000000002455 186.0
TH1_k127_1871696_5 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000000000000000000000000000001837 150.0
TH1_k127_1871696_6 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000006332 141.0
TH1_k127_1938526_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 2.834e-242 766.0
TH1_k127_1938526_1 aspartate ornithine carbamoyltransferase, carbamoyl-P binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 445.0
TH1_k127_1938526_2 Mitochondrial small ribosomal subunit Rsm22 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 382.0
TH1_k127_1938526_3 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 299.0
TH1_k127_1938526_4 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.00000000000000000000000000000000000000000000000000000000000000000006466 235.0
TH1_k127_1938526_5 Tetratricopeptide repeat - - - 0.000000001515 67.0
TH1_k127_2056710_0 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 596.0
TH1_k127_2056710_1 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 567.0
TH1_k127_2056710_2 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008191 537.0
TH1_k127_2056710_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 427.0
TH1_k127_2056710_4 Belongs to the UPF0285 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008868 409.0
TH1_k127_2056710_5 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000002206 192.0
TH1_k127_2056710_6 Putative small multi-drug export protein - - - 0.0000000000000000000000000000001463 128.0
TH1_k127_2056710_7 helicase activity K06915 - - 0.0000000000000000000000000002077 122.0
TH1_k127_209472_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 577.0
TH1_k127_209472_1 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 473.0
TH1_k127_209472_2 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000001565 225.0
TH1_k127_209472_3 - - - - 0.0000000000000000000000000000000002045 141.0
TH1_k127_209472_4 - K00960 - 2.7.7.6 0.0000000000000000000000003727 104.0
TH1_k127_2148757_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 594.0
TH1_k127_2148757_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 295.0
TH1_k127_2148757_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000001019 121.0
TH1_k127_2148757_3 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000002019 120.0
TH1_k127_2174839_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 3.869e-253 803.0
TH1_k127_2174839_1 PFAM Radical SAM domain protein K06937 - - 1.959e-247 770.0
TH1_k127_2174839_10 Belongs to the UPF0235 family K09131 - - 0.00000000000000000000004315 101.0
TH1_k127_2174839_11 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000001587 90.0
TH1_k127_2174839_12 bacterial-type flagellum-dependent cell motility - - - 0.000000004858 67.0
TH1_k127_2174839_13 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000005754 49.0
TH1_k127_2174839_2 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 602.0
TH1_k127_2174839_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 550.0
TH1_k127_2174839_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 499.0
TH1_k127_2174839_5 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 428.0
TH1_k127_2174839_6 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 428.0
TH1_k127_2174839_7 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 348.0
TH1_k127_2174839_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000003776 198.0
TH1_k127_2174839_9 Uncharacterised protein family UPF0058 - - - 0.0000000000000000000000000000000000000000481 153.0
TH1_k127_2194500_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 4.4e-259 801.0
TH1_k127_2194500_1 Nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 408.0
TH1_k127_2194500_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000004144 231.0
TH1_k127_2194500_3 - - - - 0.0000000000000000000000446 103.0
TH1_k127_2252519_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000947 331.0
TH1_k127_2252519_1 NTPase - - - 0.0000000000000000000000000000000000000000000095 168.0
TH1_k127_2252519_2 Belongs to the UPF0216 family K09737 - - 0.0001211 45.0
TH1_k127_2436236_0 TIGRFAM daunorubicin resistance ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 446.0
TH1_k127_2436236_1 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008319 400.0
TH1_k127_2436236_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 292.0
TH1_k127_2436236_3 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001295 270.0
TH1_k127_2436236_4 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000000000000000000000001004 143.0
TH1_k127_2436236_5 DEAD DEAH box helicase K03724 - - 0.000000000000001014 83.0
TH1_k127_2436236_6 PBS lyase K22221 - - 0.000000004153 61.0
TH1_k127_2436236_7 - - - - 0.000000007527 68.0
TH1_k127_244574_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1399.0
TH1_k127_244574_1 PFAM PilT protein domain protein K06865 - - 4.714e-302 936.0
TH1_k127_244574_10 - - - - 0.000000003203 65.0
TH1_k127_244574_11 COG1403 Restriction endonuclease K10726 - - 0.0000001454 56.0
TH1_k127_244574_12 - - - - 0.000000178 61.0
TH1_k127_244574_13 COG1403 Restriction endonuclease K10726 - - 0.0000009381 53.0
TH1_k127_244574_2 PFAM 4-vinyl reductase, 4VR K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009375 606.0
TH1_k127_244574_3 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 362.0
TH1_k127_244574_4 TIGRFAM cell division ATPase MinD K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 358.0
TH1_k127_244574_5 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.00000000000000000000000000000000000000000000000000000000000000000000000385 253.0
TH1_k127_244574_6 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000000005051 192.0
TH1_k127_244574_7 Protein of unknown function (DUF473) K09135 - - 0.00000000000000000000000000000000000000000001665 164.0
TH1_k127_244574_8 - - - - 0.000000000000000000000000000000000000001758 155.0
TH1_k127_244574_9 - - - - 0.0000000000000000000000000000000009928 132.0
TH1_k127_2451660_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1133.0
TH1_k127_2451660_1 coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00125 - 1.17.1.9 1.039e-224 700.0
TH1_k127_2451660_10 ATP- binding - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000005897 90.0
TH1_k127_2451660_2 ATP-grasp domain K06914 - 6.3.4.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 412.0
TH1_k127_2451660_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 407.0
TH1_k127_2451660_4 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 366.0
TH1_k127_2451660_5 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 335.0
TH1_k127_2451660_6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003921 274.0
TH1_k127_2451660_7 Transcriptional regulator, TrmB - - - 0.00000000000000000000000000000000000000000000003619 173.0
TH1_k127_2451660_8 - - - - 0.0000000000000000000000000000000000000000001393 164.0
TH1_k127_2451660_9 - - - - 0.0000000000000000000002722 103.0
TH1_k127_2509194_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.021e-307 969.0
TH1_k127_2509194_1 Protein of unknown function, DUF255 K06888 - - 5.803e-223 712.0
TH1_k127_2509194_10 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 387.0
TH1_k127_2509194_11 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 372.0
TH1_k127_2509194_12 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 356.0
TH1_k127_2509194_13 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 353.0
TH1_k127_2509194_14 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 324.0
TH1_k127_2509194_15 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 311.0
TH1_k127_2509194_16 COG1194 A G-specific DNA glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 289.0
TH1_k127_2509194_17 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008792 268.0
TH1_k127_2509194_18 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000001951 265.0
TH1_k127_2509194_19 TIGRFAM formate dehydrogenase family accessory protein FdhD K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000003783 238.0
TH1_k127_2509194_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 4.244e-200 630.0
TH1_k127_2509194_20 protein conserved in bacteria (DUF2179) - - - 0.000000000000000000000000000000000000000000000000000000000000000647 224.0
TH1_k127_2509194_21 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000000000104 221.0
TH1_k127_2509194_22 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000135 216.0
TH1_k127_2509194_23 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000001601 213.0
TH1_k127_2509194_24 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000003574 213.0
TH1_k127_2509194_25 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K07025 - - 0.000000000000000000000000000000000000000000000000000000001873 208.0
TH1_k127_2509194_26 - - - - 0.00000000000000000000000000000000000000000000000000000005591 199.0
TH1_k127_2509194_27 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000001505 198.0
TH1_k127_2509194_28 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000000000000000000000000000000002588 187.0
TH1_k127_2509194_29 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000003669 175.0
TH1_k127_2509194_3 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 1.279e-199 635.0
TH1_k127_2509194_30 PFAM Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000000000000000003517 170.0
TH1_k127_2509194_31 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000002028 160.0
TH1_k127_2509194_32 Protein of unknown function (DUF2769) - - - 0.00000000000000000000000000000000000000006665 153.0
TH1_k127_2509194_33 Cobalamin biosynthesis protein CbiG K02189 - 3.7.1.12 0.00000000000000000000000000003836 128.0
TH1_k127_2509194_34 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000001225 106.0
TH1_k127_2509194_35 PFAM Uncharacterised conserved protein UCP006577 - - - 0.00000000000000000002656 93.0
TH1_k127_2509194_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004745 572.0
TH1_k127_2509194_5 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 561.0
TH1_k127_2509194_6 COG0607 Rhodanese-related sulfurtransferase K01011,K01069 - 2.8.1.1,2.8.1.2,3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 554.0
TH1_k127_2509194_7 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 539.0
TH1_k127_2509194_8 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 512.0
TH1_k127_2509194_9 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 386.0
TH1_k127_2516984_0 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 437.0
TH1_k127_2516984_1 PFAM glutamate synthase alpha subunit domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 339.0
TH1_k127_2516984_2 Belongs to the glutamate synthase family - - - 0.000000000000000000000000000000000000000000000000000000000000000004618 226.0
TH1_k127_2516984_3 PFAM PKD domain containing protein - - - 0.0008138 45.0
TH1_k127_2518943_0 CHAD domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 392.0
TH1_k127_2518943_1 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000004998 231.0
TH1_k127_2518943_2 Alpha beta hydrolase fold - - - 0.00000000000000000000000003116 111.0
TH1_k127_2538314_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.177e-277 870.0
TH1_k127_2538314_1 PFAM AAA ATPase central domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 566.0
TH1_k127_2538314_10 - - - - 0.000000000000134 72.0
TH1_k127_2538314_2 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 415.0
TH1_k127_2538314_3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006161 381.0
TH1_k127_2538314_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 378.0
TH1_k127_2538314_5 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 335.0
TH1_k127_2538314_6 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 330.0
TH1_k127_2538314_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000000000000000000000006097 136.0
TH1_k127_2538314_8 protein conserved in archaea - - - 0.0000000000000000000000000000000001247 135.0
TH1_k127_2538314_9 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000004261 95.0
TH1_k127_2555142_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 8.749e-261 817.0
TH1_k127_2555142_1 Predicted membrane protein (DUF2070) K08979 - - 5.913e-206 655.0
TH1_k127_2555142_10 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 507.0
TH1_k127_2555142_11 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 506.0
TH1_k127_2555142_12 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 474.0
TH1_k127_2555142_13 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 447.0
TH1_k127_2555142_14 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 449.0
TH1_k127_2555142_15 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 438.0
TH1_k127_2555142_16 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 410.0
TH1_k127_2555142_17 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 407.0
TH1_k127_2555142_18 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 392.0
TH1_k127_2555142_19 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 376.0
TH1_k127_2555142_2 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 5.746e-200 631.0
TH1_k127_2555142_20 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 374.0
TH1_k127_2555142_21 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 370.0
TH1_k127_2555142_22 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 362.0
TH1_k127_2555142_23 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 320.0
TH1_k127_2555142_24 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 293.0
TH1_k127_2555142_25 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 283.0
TH1_k127_2555142_26 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000116 291.0
TH1_k127_2555142_27 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 288.0
TH1_k127_2555142_28 Oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 282.0
TH1_k127_2555142_29 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 283.0
TH1_k127_2555142_3 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 2.093e-194 609.0
TH1_k127_2555142_30 Fe-S type, tartrate fumarate subfamily, beta K01678 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004273 270.0
TH1_k127_2555142_31 methanogen marker protein 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008997 262.0
TH1_k127_2555142_32 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001164 270.0
TH1_k127_2555142_33 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001094 252.0
TH1_k127_2555142_34 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003436 239.0
TH1_k127_2555142_35 TIGRFAM cytidyltransferase-related domain K02201 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000001682 232.0
TH1_k127_2555142_36 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000002682 220.0
TH1_k127_2555142_37 Pas domain - - - 0.00000000000000000000000000000000000000000000000000000002897 224.0
TH1_k127_2555142_38 PFAM peptidase zinc-dependent K06974 - - 0.0000000000000000000000000000000000000000000000000000001126 201.0
TH1_k127_2555142_39 Belongs to the UPF0212 family K09731 - - 0.000000000000000000000000000000000000000000000000000001449 193.0
TH1_k127_2555142_4 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 5.515e-194 611.0
TH1_k127_2555142_40 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000003455 187.0
TH1_k127_2555142_41 Thioesterase superfamily K02614 - - 0.00000000000000000000000000000000000000000000002403 173.0
TH1_k127_2555142_42 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.000000000000000000000000000000000000000000007871 163.0
TH1_k127_2555142_43 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000000000000004217 166.0
TH1_k127_2555142_44 Belongs to the UPF0146 family K09713 - - 0.000000000000000000000000000000000000000009273 158.0
TH1_k127_2555142_45 Pas domain - - - 0.000000000000000000000000000000000000001189 170.0
TH1_k127_2555142_46 - - - - 0.0000000000000000000000000000000005088 134.0
TH1_k127_2555142_47 - - - - 0.00000000000000000000000000001607 119.0
TH1_k127_2555142_48 secretion by the type IV secretion system K07332 - - 0.00000000000000000000000000001741 128.0
TH1_k127_2555142_49 transcription factor (CBF NF-Y) - - - 0.000000000000000000000000001202 112.0
TH1_k127_2555142_5 TIGRFAM small GTP-binding protein K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008337 569.0
TH1_k127_2555142_50 Alternative locus ID - - - 0.0000000000000000000000001975 122.0
TH1_k127_2555142_51 Family of unknown function (DUF5350) - - - 0.0000000000000000000000003741 108.0
TH1_k127_2555142_52 - - - - 0.0000000000000000000001867 100.0
TH1_k127_2555142_53 PFAM TPR repeat-containing protein - - - 0.000000000000000000000794 99.0
TH1_k127_2555142_54 - - - - 0.00000000000000138 78.0
TH1_k127_2555142_55 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000007497 59.0
TH1_k127_2555142_56 PFAM TPR repeat-containing protein - - - 0.000005772 51.0
TH1_k127_2555142_6 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 561.0
TH1_k127_2555142_7 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 572.0
TH1_k127_2555142_8 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 541.0
TH1_k127_2555142_9 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 516.0
TH1_k127_257107_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 554.0
TH1_k127_257107_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 525.0
TH1_k127_257107_2 Dihydrouridine synthase (Dus) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 511.0
TH1_k127_257107_3 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 462.0
TH1_k127_257107_4 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 408.0
TH1_k127_257107_5 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 368.0
TH1_k127_257107_6 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000006516 217.0
TH1_k127_257107_7 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.000000000000000000000000000000000000000000000000000001496 194.0
TH1_k127_257107_8 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000000000000000000000006295 175.0
TH1_k127_257107_9 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000000003724 160.0
TH1_k127_2604628_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 6.946e-299 925.0
TH1_k127_2604628_1 Domain of unknown function (DUF3821) - - - 1.45e-290 918.0
TH1_k127_2604628_10 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 400.0
TH1_k127_2604628_11 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 372.0
TH1_k127_2604628_12 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008914 362.0
TH1_k127_2604628_13 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 360.0
TH1_k127_2604628_14 methylase K00571 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 364.0
TH1_k127_2604628_15 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 356.0
TH1_k127_2604628_16 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 361.0
TH1_k127_2604628_17 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 354.0
TH1_k127_2604628_18 Involved in cell shape control K22222 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 321.0
TH1_k127_2604628_19 Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 287.0
TH1_k127_2604628_2 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 2.452e-239 748.0
TH1_k127_2604628_20 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001608 268.0
TH1_k127_2604628_21 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009796 268.0
TH1_k127_2604628_22 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004992 265.0
TH1_k127_2604628_23 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001461 261.0
TH1_k127_2604628_24 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008924 258.0
TH1_k127_2604628_25 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000332 251.0
TH1_k127_2604628_26 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004269 239.0
TH1_k127_2604628_27 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000001118 239.0
TH1_k127_2604628_28 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001969 250.0
TH1_k127_2604628_29 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000000007073 226.0
TH1_k127_2604628_3 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 589.0
TH1_k127_2604628_30 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000000000000000000001248 224.0
TH1_k127_2604628_31 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000000000000001519 217.0
TH1_k127_2604628_32 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000002156 216.0
TH1_k127_2604628_33 binds to the 23S rRNA K02885 - - 0.00000000000000000000000000000000000000000000000000000000000003056 217.0
TH1_k127_2604628_34 binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000000004432 198.0
TH1_k127_2604628_35 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000000000000000000000000001275 189.0
TH1_k127_2604628_36 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000005045 187.0
TH1_k127_2604628_37 PFAM Ribosomal protein K02912 - - 0.0000000000000000000000000000000000000000000009704 169.0
TH1_k127_2604628_38 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.00000000000000000000000000000000000000000002835 165.0
TH1_k127_2604628_39 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.0000000000000000000000000003558 116.0
TH1_k127_2604628_4 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 539.0
TH1_k127_2604628_40 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 - 3.1.26.5 0.00000000000000000000000001377 111.0
TH1_k127_2604628_41 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000000000006383 107.0
TH1_k127_2604628_42 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000000000000209 103.0
TH1_k127_2604628_43 - - - - 0.000000000000000000002958 99.0
TH1_k127_2604628_5 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 508.0
TH1_k127_2604628_6 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009207 482.0
TH1_k127_2604628_7 Ribonuclease R winged-helix domain K09720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 451.0
TH1_k127_2604628_8 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 412.0
TH1_k127_2604628_9 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 397.0
TH1_k127_2623055_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 6.299e-263 813.0
TH1_k127_2623055_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 570.0
TH1_k127_2623055_10 PFAM nucleoside recognition domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003778 275.0
TH1_k127_2623055_11 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000223 250.0
TH1_k127_2623055_12 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000002289 237.0
TH1_k127_2623055_13 RibD C-terminal domain K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000005664 209.0
TH1_k127_2623055_14 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000000000000001808 169.0
TH1_k127_2623055_15 Anion transporter K14445 - - 0.00000000000000000000000000000000000003866 147.0
TH1_k127_2623055_16 integral membrane protein - - - 0.0000000000000000000000000000000000007706 148.0
TH1_k127_2623055_17 Belongs to the TrpF family K01696,K01817 - 4.2.1.20,5.3.1.24 0.0000000000000000000000000000004215 129.0
TH1_k127_2623055_18 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.000000000000000000000000001519 118.0
TH1_k127_2623055_19 Transcriptional regulator K07729 - - 0.00000000000000000000000007349 109.0
TH1_k127_2623055_2 Radical SAM ThiC family K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 467.0
TH1_k127_2623055_20 Psort location Cytoplasmic, score - - - 0.0000000000000000000000004022 119.0
TH1_k127_2623055_21 - - - - 0.0000000000000000000006846 100.0
TH1_k127_2623055_22 - - - - 0.000000000000002946 84.0
TH1_k127_2623055_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 463.0
TH1_k127_2623055_4 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009372 389.0
TH1_k127_2623055_5 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 377.0
TH1_k127_2623055_6 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005189 284.0
TH1_k127_2623055_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009002 277.0
TH1_k127_2623055_8 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000785 274.0
TH1_k127_2623055_9 PFAM NAD(P)H dehydrogenase (quinone) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000279 271.0
TH1_k127_2778752_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 302.0
TH1_k127_2778752_1 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001862 256.0
TH1_k127_2778752_2 COG1202 Superfamily II helicase, archaea-specific - - - 0.000000000000000000000000000000000000000000000000000000000000521 213.0
TH1_k127_2778752_3 - - - - 0.0000000000036 72.0
TH1_k127_3002560_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 2.866e-283 879.0
TH1_k127_3002560_1 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 1.535e-264 820.0
TH1_k127_3002560_10 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000001314 147.0
TH1_k127_3002560_11 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000001785 125.0
TH1_k127_3002560_12 - - - - 0.0000000000000000000000001899 108.0
TH1_k127_3002560_2 Belongs to the RtcB family K14415 - 6.5.1.3 1.597e-226 709.0
TH1_k127_3002560_3 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 508.0
TH1_k127_3002560_4 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 285.0
TH1_k127_3002560_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001312 238.0
TH1_k127_3002560_6 PFAM ABC transporter K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000001559 242.0
TH1_k127_3002560_7 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.000000000000000000000000000000000000000000000000000000000004466 210.0
TH1_k127_3002560_8 PFAM ABC transporter K16786 - - 0.0000000000000000000000000000000000000000000000000000000009512 208.0
TH1_k127_3002560_9 PFAM BioY protein K03523 - - 0.00000000000000000000000000000000000000000000000000001804 194.0
TH1_k127_3023499_0 PFAM CBS domain - - - 5.13e-254 791.0
TH1_k127_3023499_1 PFAM Metallophosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009744 256.0
TH1_k127_3023499_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000001341 190.0
TH1_k127_3023499_3 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000001704 163.0
TH1_k127_3023499_4 NIF3 (NGG1p interacting factor 3) - - - 0.0000004489 52.0
TH1_k127_3178199_0 Belongs to the glutamate synthase family - - - 1.557e-275 852.0
TH1_k127_3178199_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 2.548e-232 725.0
TH1_k127_3178199_2 PFAM glutamine amidotransferase, class-II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 553.0
TH1_k127_3178199_3 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 387.0
TH1_k127_3178199_4 PFAM glutamate synthase alpha subunit domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 358.0
TH1_k127_3179694_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 3.875e-230 723.0
TH1_k127_3179694_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 609.0
TH1_k127_3179694_10 PFAM ADP-ribosylation Crystallin J1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000723 288.0
TH1_k127_3179694_11 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000007332 222.0
TH1_k127_3179694_12 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000000000000000000003163 184.0
TH1_k127_3179694_13 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000005236 188.0
TH1_k127_3179694_14 protein conserved in archaea K09723 - - 0.00000000000000000000000000000000000000000000000006203 187.0
TH1_k127_3179694_15 TfuA-like protein - - - 0.000000000000000000000000000000000000002884 155.0
TH1_k127_3179694_16 metal-binding protein - - - 0.000000000000000000000000000001255 123.0
TH1_k127_3179694_17 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000003689 99.0
TH1_k127_3179694_18 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000000000001645 98.0
TH1_k127_3179694_19 PFAM Yip1 domain - - - 0.00000000000000000003213 98.0
TH1_k127_3179694_2 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 548.0
TH1_k127_3179694_20 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.0000000000001938 73.0
TH1_k127_3179694_3 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009295 534.0
TH1_k127_3179694_4 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 525.0
TH1_k127_3179694_5 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 463.0
TH1_k127_3179694_6 PHP C-terminal domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 437.0
TH1_k127_3179694_7 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 366.0
TH1_k127_3179694_8 PFAM TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 363.0
TH1_k127_3179694_9 PAC2 family K07159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 325.0
TH1_k127_3238592_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 2.022e-247 772.0
TH1_k127_3238592_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 286.0
TH1_k127_3238592_2 PIN domain of ribonuclease K07060 - - 0.00000000000001502 73.0
TH1_k127_3238592_3 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.00007814 47.0
TH1_k127_3319426_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 548.0
TH1_k127_3319426_1 PFAM formate nitrite transporter K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 454.0
TH1_k127_3319426_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 450.0
TH1_k127_3319426_3 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 433.0
TH1_k127_3319426_4 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 371.0
TH1_k127_3319426_5 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 325.0
TH1_k127_3319426_6 PFAM nucleic acid binding, OB-fold, tRNA helicase-type - - - 0.0000000000000000000000000000000000000000000000000008421 193.0
TH1_k127_3319426_7 - K06868 - 2.5.1.73 0.0000000000001383 72.0
TH1_k127_3325355_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 7.891e-238 740.0
TH1_k127_3325355_1 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 6.221e-232 722.0
TH1_k127_3325355_10 PFAM Desulfoferrodoxin ferrous iron-binding region K05919 - 1.15.1.2 0.000000000000000000000000000000000000000007489 158.0
TH1_k127_3325355_11 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000000000000143 104.0
TH1_k127_3325355_12 COG0607 Rhodanese-related sulfurtransferase K03151 - 2.8.1.4 0.0000000000000000000002908 100.0
TH1_k127_3325355_2 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 592.0
TH1_k127_3325355_3 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004172 566.0
TH1_k127_3325355_4 Protein of unknown function (DUF475) K09799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006454 465.0
TH1_k127_3325355_5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 308.0
TH1_k127_3325355_6 COG0433 Predicted ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007895 274.0
TH1_k127_3325355_7 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001818 244.0
TH1_k127_3325355_8 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000051 213.0
TH1_k127_3325355_9 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000003139 172.0
TH1_k127_347033_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 2.226e-208 653.0
TH1_k127_347033_1 Belongs to the peptidase M24B family - - - 1.084e-203 639.0
TH1_k127_347033_2 domain, Protein K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 563.0
TH1_k127_347033_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 319.0
TH1_k127_347033_4 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000803 250.0
TH1_k127_347033_5 Sigma factor PP2C-like phosphatases - - - 0.00000000000000000000000000000000001503 143.0
TH1_k127_3475448_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1048.0
TH1_k127_3475448_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 1.246e-199 637.0
TH1_k127_3475448_2 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 421.0
TH1_k127_3475448_3 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 326.0
TH1_k127_3475448_4 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000022 248.0
TH1_k127_3475448_5 aminopeptidase N - - - 0.000000000000000000000000000000000000000000000001479 185.0
TH1_k127_3475448_6 response regulator - - - 0.00000000000000000000000000000001888 139.0
TH1_k127_3475448_7 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000002493 99.0
TH1_k127_3518215_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 565.0
TH1_k127_3518215_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 361.0
TH1_k127_3518215_2 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 302.0
TH1_k127_3518215_3 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.00000000000000000000000000000002673 130.0
TH1_k127_3518215_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000539 104.0
TH1_k127_3670262_0 CBS domain containing protein K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 492.0
TH1_k127_3700987_0 PFAM Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000000518 188.0
TH1_k127_3700987_1 - - - - 0.0000007985 54.0
TH1_k127_3700987_2 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00008226 45.0
TH1_k127_3706101_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1493.0
TH1_k127_3706101_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.936e-314 973.0
TH1_k127_3706101_2 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 3.879e-196 625.0
TH1_k127_3706101_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 598.0
TH1_k127_3706101_4 - - - - 0.000000000000000004345 85.0
TH1_k127_3714652_0 DEAD DEAH box helicase domain protein K03724 - - 0.0 1275.0
TH1_k127_3714652_1 Belongs to the MCM family K10726 - - 0.0 1095.0
TH1_k127_3714652_10 Replication factor C K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 367.0
TH1_k127_3714652_11 PFAM TatD-related deoxyribonuclease K07049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 356.0
TH1_k127_3714652_12 pfam nmd3 K07562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 342.0
TH1_k127_3714652_13 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 323.0
TH1_k127_3714652_14 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 316.0
TH1_k127_3714652_15 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 306.0
TH1_k127_3714652_16 PFAM GHMP kinase K06982 - 2.7.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004739 278.0
TH1_k127_3714652_17 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005235 270.0
TH1_k127_3714652_18 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006648 271.0
TH1_k127_3714652_19 Pfam:DUF137 K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000000000002587 252.0
TH1_k127_3714652_2 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 4.331e-292 904.0
TH1_k127_3714652_20 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.00000000000000000000000000000000002581 137.0
TH1_k127_3714652_21 protein conserved in archaea K09746 - - 0.00000000000000000000000000000007213 134.0
TH1_k127_3714652_22 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000000001307 114.0
TH1_k127_3714652_23 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000008443 84.0
TH1_k127_3714652_24 - - - - 0.000000000000007458 90.0
TH1_k127_3714652_25 - - - - 0.0000000000007094 84.0
TH1_k127_3714652_26 - - - - 0.000000001387 65.0
TH1_k127_3714652_3 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 9.872e-280 868.0
TH1_k127_3714652_4 PFAM PKD domain containing protein - - - 1.369e-225 752.0
TH1_k127_3714652_5 PFAM PKD domain containing protein - - - 1.617e-204 695.0
TH1_k127_3714652_6 PFAM AIR synthase related protein K07388 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 569.0
TH1_k127_3714652_7 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002144 504.0
TH1_k127_3714652_8 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 469.0
TH1_k127_3714652_9 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 462.0
TH1_k127_3767929_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.797e-266 827.0
TH1_k127_3767929_1 P-loop Domain of unknown function (DUF2791) K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 551.0
TH1_k127_3767929_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 431.0
TH1_k127_3767929_3 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 437.0
TH1_k127_3767929_4 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005949 256.0
TH1_k127_3767929_5 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000001365 157.0
TH1_k127_3767929_6 - - - - 0.0000000000000000000000002684 107.0
TH1_k127_3791193_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.0 1041.0
TH1_k127_3791193_1 DEAD DEAH box helicase domain protein K03725 - - 3.009e-295 920.0
TH1_k127_3791193_10 ribosomal protein S15 K02956 - - 0.000000000000000000000000000000000000000000000000000000000000000000004858 236.0
TH1_k127_3791193_11 - - - - 0.0000000000000000000000000000000000000000000000000000000004763 230.0
TH1_k127_3791193_12 ArsR transcriptional regulator - - - 0.0000000000000000000000000000000000000000003739 163.0
TH1_k127_3791193_13 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000001247 128.0
TH1_k127_3791193_14 Belongs to the UPF0248 family K09715 - - 0.000000000000000000000122 100.0
TH1_k127_3791193_15 membrane K09167 - - 0.000000000000000000002875 100.0
TH1_k127_3791193_16 - - - - 0.0000000000000007332 81.0
TH1_k127_3791193_17 - - - - 0.0000004561 64.0
TH1_k127_3791193_2 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 8.583e-256 796.0
TH1_k127_3791193_3 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 596.0
TH1_k127_3791193_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007048 557.0
TH1_k127_3791193_5 SMART regulatory protein, Crp K07730 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 422.0
TH1_k127_3791193_6 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008925 418.0
TH1_k127_3791193_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 295.0
TH1_k127_3791193_8 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 284.0
TH1_k127_3791193_9 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009347 288.0
TH1_k127_380340_0 Ammonium Transporter Family K03320 - - 2.238e-194 613.0
TH1_k127_380340_1 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 408.0
TH1_k127_380340_10 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000001301 161.0
TH1_k127_380340_11 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000000002592 146.0
TH1_k127_380340_12 - - - - 0.000000000000000000000000000000001969 136.0
TH1_k127_380340_13 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000000000000000000000000000003568 136.0
TH1_k127_380340_14 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000003099 123.0
TH1_k127_380340_15 - K00960 - 2.7.7.6 0.0000000000000000000000000001396 115.0
TH1_k127_380340_16 - - - - 0.0000000000001234 73.0
TH1_k127_380340_17 HEAT repeats - - - 0.00000000000141 72.0
TH1_k127_380340_18 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.0000000001283 73.0
TH1_k127_380340_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 397.0
TH1_k127_380340_3 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 385.0
TH1_k127_380340_4 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 335.0
TH1_k127_380340_5 sensor histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 347.0
TH1_k127_380340_6 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006578 267.0
TH1_k127_380340_7 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006487 288.0
TH1_k127_380340_8 Belongs to the UPF0215 family K09120 - - 0.00000000000000000000000000000000000000000000000000000000000000000008441 235.0
TH1_k127_380340_9 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000009377 185.0
TH1_k127_3809548_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 1.815e-281 879.0
TH1_k127_3809548_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.327e-198 627.0
TH1_k127_3809548_2 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 406.0
TH1_k127_3809548_3 Belongs to the PdaD family K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 302.0
TH1_k127_3809548_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000005866 259.0
TH1_k127_3809548_5 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000003084 173.0
TH1_k127_3809548_6 Protein of unknown function (DUF998) - - - 0.000000000000000000000000000000000000009272 150.0
TH1_k127_3809548_7 - - - - 0.0000000000000000000104 101.0
TH1_k127_3874665_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 606.0
TH1_k127_3874665_1 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000005329 226.0
TH1_k127_3874665_2 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000000000000000000000000000000002724 181.0
TH1_k127_3874665_3 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.00000000000000000000000000000000000000001038 155.0
TH1_k127_3874665_4 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171,K00188 - 1.2.7.1,1.2.7.7 0.00000000000000000000000000000000001786 140.0
TH1_k127_3874665_5 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.000000000000000000000000006803 111.0
TH1_k127_3908644_0 PFAM Mannosyl oligosaccharide glucosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005688 586.0
TH1_k127_3908644_1 Membrane - - - 0.00000000000000001306 93.0
TH1_k127_4089440_0 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 2.047e-194 613.0
TH1_k127_4089440_1 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 387.0
TH1_k127_4089440_2 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) - - - 0.00000000000000000000000000000000000000000000000000000000001193 208.0
TH1_k127_4089440_3 Hydrogenase maturation protease K08315 - 3.4.23.51 0.0000000000000000000000000000000000000006445 153.0
TH1_k127_4089440_4 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.0000000000000000000000000000000000001872 143.0
TH1_k127_4089440_5 META domain - - - 0.000000000000000000321 93.0
TH1_k127_4089440_6 Short repeat of unknown function (DUF308) - - - 0.00000000000003872 76.0
TH1_k127_4089762_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 3.694e-299 926.0
TH1_k127_4089762_1 Fe-S protein PflX, homolog of pyruvate formate lyase activating K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 378.0
TH1_k127_4089762_10 PFAM TPR repeat-containing protein - - - 0.0000000000000003087 82.0
TH1_k127_4089762_11 membrane - - - 0.00000001079 65.0
TH1_k127_4089762_2 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 312.0
TH1_k127_4089762_3 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003863 295.0
TH1_k127_4089762_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006502 261.0
TH1_k127_4089762_5 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001382 269.0
TH1_k127_4089762_6 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.000000000000000000000000000000000000000000000009281 175.0
TH1_k127_4089762_7 transcription factor (CBF NF-Y) - - - 0.0000000000000000000008495 96.0
TH1_k127_4089762_8 - - - - 0.000000000000000003324 87.0
TH1_k127_4089762_9 PFAM TPR repeat-containing protein - - - 0.000000000000000008087 87.0
TH1_k127_4112236_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1181.0
TH1_k127_4112236_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004166 267.0
TH1_k127_4112236_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000001062 208.0
TH1_k127_4112236_3 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000004704 192.0
TH1_k127_4112236_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000003887 100.0
TH1_k127_4112236_5 - - - - 0.0007747 43.0
TH1_k127_4118329_0 ATPase family associated with various cellular activities (AAA) - - - 5.133e-235 737.0
TH1_k127_4118329_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 1.065e-207 649.0
TH1_k127_4118329_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 351.0
TH1_k127_4118329_11 heterodisulfide reductase subunit C K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 334.0
TH1_k127_4118329_12 unfolded protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006278 317.0
TH1_k127_4118329_13 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 299.0
TH1_k127_4118329_14 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000005926 216.0
TH1_k127_4118329_15 WD-40 repeat protein - - - 0.0000000000000000000000000000000000000000000002213 192.0
TH1_k127_4118329_16 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11260 - - 0.000000000000000000000000000000000000001978 148.0
TH1_k127_4118329_17 Protein of unknown function (DUF1257) - - - 0.00000000005155 66.0
TH1_k127_4118329_18 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000009169 56.0
TH1_k127_4118329_19 Protein of unknown function (DUF2997) - - - 0.000007971 50.0
TH1_k127_4118329_2 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 556.0
TH1_k127_4118329_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 542.0
TH1_k127_4118329_4 CoB--CoM heterodisulfide reductase subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 520.0
TH1_k127_4118329_5 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008989 518.0
TH1_k127_4118329_6 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 432.0
TH1_k127_4118329_7 Domain of unknown function (DUF1743) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 418.0
TH1_k127_4118329_8 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 363.0
TH1_k127_4118329_9 PFAM Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 358.0
TH1_k127_4141742_0 KH, type 1, domain K07041 - - 0.0 1137.0
TH1_k127_4141742_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 9.415e-213 672.0
TH1_k127_4141742_10 Zinc-uptake complex component A periplasmic K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000005444 236.0
TH1_k127_4141742_11 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000006832 186.0
TH1_k127_4141742_12 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000001788 176.0
TH1_k127_4141742_13 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000003909 171.0
TH1_k127_4141742_14 RuvA, C-terminal domain K03550 - 3.6.4.12 0.000000000000000000000000000000000000000001629 163.0
TH1_k127_4141742_15 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000009936 78.0
TH1_k127_4141742_16 CHAD domain containing protein - - - 0.0009916 48.0
TH1_k127_4141742_2 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 570.0
TH1_k127_4141742_3 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 445.0
TH1_k127_4141742_4 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 429.0
TH1_k127_4141742_5 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 385.0
TH1_k127_4141742_6 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 332.0
TH1_k127_4141742_7 ATPases associated with a variety of cellular activities K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 316.0
TH1_k127_4141742_8 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 311.0
TH1_k127_4141742_9 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 295.0
TH1_k127_4289343_0 PFAM dihydropteroate synthase, DHPS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 552.0
TH1_k127_4289343_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004518 280.0
TH1_k127_4289343_2 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000004507 213.0
TH1_k127_4289343_3 Prokaryotic homologs of the JAB domain - - - 0.0000000000000000000000000000000000000000000000000000000004677 209.0
TH1_k127_4297555_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 3.826e-208 653.0
TH1_k127_4297555_1 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 524.0
TH1_k127_4297555_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006621 394.0
TH1_k127_4297555_3 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000928 226.0
TH1_k127_4297555_4 - - - - 0.00000000000000000000002021 107.0
TH1_k127_4475738_0 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 474.0
TH1_k127_4475738_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 460.0
TH1_k127_4475738_10 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002154 224.0
TH1_k127_4475738_11 PFAM Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000000000000000000000000004438 193.0
TH1_k127_4475738_12 PFAM Uncharacterised protein family (UPF0153) - - - 0.0000000000000000000000000000000000000000000000000001192 189.0
TH1_k127_4475738_13 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000001144 189.0
TH1_k127_4475738_14 Nitroreductase - - - 0.00000000000000000000000000000000000000000000001104 186.0
TH1_k127_4475738_15 - - - - 0.00000000000000000000000000000000000000000000001675 177.0
TH1_k127_4475738_16 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000005378 160.0
TH1_k127_4475738_17 CBS domain - - - 0.0000000000000000000000000000000003491 135.0
TH1_k127_4475738_18 Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins. K15383 - - 0.00000000004793 67.0
TH1_k127_4475738_2 methanogenesis marker protein 11 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 429.0
TH1_k127_4475738_3 PFAM ABC transporter related K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 412.0
TH1_k127_4475738_4 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005646 391.0
TH1_k127_4475738_5 permease K03299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 377.0
TH1_k127_4475738_6 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 330.0
TH1_k127_4475738_7 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 289.0
TH1_k127_4475738_8 NAD(P)H-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001827 267.0
TH1_k127_4475738_9 PFAM Isochorismatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006577 244.0
TH1_k127_4611377_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.059e-295 915.0
TH1_k127_4611377_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 1.11e-259 805.0
TH1_k127_4611377_10 Respiratory-chain NADH dehydrogenase, 30 Kd subunit K14089 - - 0.00000000000000000000000000000000000000000005154 163.0
TH1_k127_4611377_11 Formate hydrogenlyase subunit 6 NADH ubiquinone oxidoreductase 23 kD subunit (chain I) K14091,K15831 - - 0.00000000000000000000000000000000000000000006127 164.0
TH1_k127_4611377_12 Endonuclease V K05982 - 3.1.21.7 0.000000000000000000000000000000000000000002804 164.0
TH1_k127_4611377_13 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000000000000000000019 139.0
TH1_k127_4611377_14 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000000006063 127.0
TH1_k127_4611377_15 ATP synthase subunit C K02124 - - 0.000000000000000000001526 95.0
TH1_k127_4611377_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000002768 83.0
TH1_k127_4611377_18 cell adhesion involved in biofilm formation - - - 0.000000000000008592 82.0
TH1_k127_4611377_2 PFAM NADH Ubiquinone plastoquinone (complex I) K14086 - - 5.489e-250 786.0
TH1_k127_4611377_3 V-type ATPase 116kDa subunit family K02123 - - 8.148e-203 650.0
TH1_k127_4611377_4 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 578.0
TH1_k127_4611377_5 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 410.0
TH1_k127_4611377_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 366.0
TH1_k127_4611377_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 306.0
TH1_k127_4611377_8 FHA domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 291.0
TH1_k127_4611377_9 PFAM NADH ubiquinone oxidoreductase, 20 K14088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002293 273.0
TH1_k127_4667915_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1180.0
TH1_k127_4667915_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1056.0
TH1_k127_4801902_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1347.0
TH1_k127_4801902_1 SMART Elongator protein 3 MiaB NifB K22226 - - 8.668e-204 640.0
TH1_k127_4801902_10 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000000000000000000557 196.0
TH1_k127_4801902_11 - - - - 0.00000000000000000000000000000000002421 140.0
TH1_k127_4801902_12 TIR domain - - - 0.0000000000000005439 84.0
TH1_k127_4801902_2 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 591.0
TH1_k127_4801902_3 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008818 586.0
TH1_k127_4801902_4 Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 473.0
TH1_k127_4801902_5 PFAM metallophosphoesterase K07096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 336.0
TH1_k127_4801902_6 PFAM peptidylprolyl isomerase FKBP-type K01802,K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 297.0
TH1_k127_4801902_7 SMART regulatory protein AsnC Lrp family K22225 - - 0.0000000000000000000000000000000000000000000000000000000000000004845 223.0
TH1_k127_4801902_8 SMART regulatory protein AsnC Lrp family K22225 - - 0.000000000000000000000000000000000000000000000000000000000003969 212.0
TH1_k127_4801902_9 adenylyl cyclase CyaB K05873 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000003498 198.0
TH1_k127_4818215_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.087e-286 897.0
TH1_k127_4818215_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009566 507.0
TH1_k127_4818215_2 serine threonine protein kinase K07178 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 338.0
TH1_k127_4818215_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 327.0
TH1_k127_4818215_4 KH domain protein K06961 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009054 269.0
TH1_k127_4970569_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 2.069e-205 646.0
TH1_k127_4970569_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 537.0
TH1_k127_4970569_2 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 295.0
TH1_k127_4970569_3 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000732 278.0
TH1_k127_4970569_4 Domain of unknown function DUF123 - - - 0.0000000000000000000000000000000000002957 146.0
TH1_k127_4972101_0 - K08963 - 5.3.1.23 4.013e-299 927.0
TH1_k127_4972101_1 - - - - 0.00000000000000000000001325 103.0
TH1_k127_4972101_2 Uncharacterized protein family, UPF0114 - - - 0.0000000000000000000004911 102.0
TH1_k127_4972101_3 - - - - 0.00000000000000000008124 100.0
TH1_k127_4972101_4 PspC domain K03973 - - 0.0000000000000000006021 89.0
TH1_k127_4972101_5 small multi-drug export - - - 0.000000000000000001864 92.0
TH1_k127_5024298_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 3.007e-197 624.0
TH1_k127_5024298_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 590.0
TH1_k127_5024298_10 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001826 261.0
TH1_k127_5024298_11 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000003083 236.0
TH1_k127_5024298_12 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000001555 219.0
TH1_k127_5024298_13 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000004926 158.0
TH1_k127_5024298_14 PFAM PRC-barrel domain - - - 0.000000000000000000000000000005384 120.0
TH1_k127_5024298_15 - - - - 0.00000000000002355 78.0
TH1_k127_5024298_16 PFAM metallophosphoesterase - - - 0.000000002784 68.0
TH1_k127_5024298_2 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009627 559.0
TH1_k127_5024298_3 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 514.0
TH1_k127_5024298_4 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 473.0
TH1_k127_5024298_5 signal transduction protein with CBS domains K07744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 441.0
TH1_k127_5024298_6 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 441.0
TH1_k127_5024298_7 TIGRFAM small GTP-binding protein K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005192 417.0
TH1_k127_5024298_8 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 376.0
TH1_k127_5024298_9 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 311.0
TH1_k127_5060363_0 PFAM ABC transporter K00400 - - 1.233e-240 755.0
TH1_k127_5060363_1 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 567.0
TH1_k127_5060363_2 Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide K00399 - 2.8.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 326.0
TH1_k127_5060363_3 Belongs to the UPF0251 family K06933 - - 0.000000000000000000000000000000001029 135.0
TH1_k127_5063812_0 PFAM sodium hydrogen exchanger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 516.0
TH1_k127_5063812_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 396.0
TH1_k127_5063812_2 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 302.0
TH1_k127_5063812_3 PFAM multi antimicrobial extrusion protein MatE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006391 279.0
TH1_k127_5063812_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005079 255.0
TH1_k127_5063812_5 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000000000000000000001464 171.0
TH1_k127_5063812_6 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000000000000000000000000000000000004194 159.0
TH1_k127_5063812_7 RNA recognition motif - - - 0.0000000000000000000000000000000002267 136.0
TH1_k127_5063812_8 PFAM Uncharacterised conserved protein UCP006577 - - - 0.00000000000000000000000002361 111.0
TH1_k127_5063812_9 Uncharacterized conserved protein (DUF2196) - - - 0.00000000000000000007125 91.0
TH1_k127_5070421_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 396.0
TH1_k127_5070421_1 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 372.0
TH1_k127_5070421_2 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 285.0
TH1_k127_5070421_3 Integral membrane protein DUF106 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001064 241.0
TH1_k127_5070421_4 UPF0056 membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000001447 241.0
TH1_k127_5070421_5 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000005145 228.0
TH1_k127_5070421_6 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000000000000000001026 177.0
TH1_k127_5109779_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1159.0
TH1_k127_5109779_1 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 445.0
TH1_k127_5109779_2 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 387.0
TH1_k127_5109779_3 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 306.0
TH1_k127_5109779_4 PFAM major facilitator superfamily MFS_1 K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000298 288.0
TH1_k127_5109779_5 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000008315 237.0
TH1_k127_5109779_6 methyltransferase small K07579 - - 0.00000000000000000000000000000000000000000000000000000000000000000055 233.0
TH1_k127_5128860_0 PFAM type II secretion system protein E K07332 - - 4.097e-278 873.0
TH1_k127_5128860_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 1.035e-277 864.0
TH1_k127_5128860_10 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 351.0
TH1_k127_5128860_11 AIR carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 340.0
TH1_k127_5128860_12 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005157 258.0
TH1_k127_5128860_13 cytidyltransferase-related domain K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000002771 252.0
TH1_k127_5128860_14 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006641 250.0
TH1_k127_5128860_15 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000000000000000000000000000005014 194.0
TH1_k127_5128860_16 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.00000000000000000000000000000000000000000000002716 172.0
TH1_k127_5128860_17 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000004608 185.0
TH1_k127_5128860_18 - - - - 0.0000000000000000000000000000000000006088 142.0
TH1_k127_5128860_19 - - - - 0.0000000000000000000000000004392 115.0
TH1_k127_5128860_2 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.226e-211 671.0
TH1_k127_5128860_20 Zn-ribbon containing protein K07163 - - 0.000000000000000000000000002003 115.0
TH1_k127_5128860_21 - - - - 0.000000000000000000000001245 107.0
TH1_k127_5128860_22 PFAM Roadblock LC7 family protein - - - 0.00000000000000001801 83.0
TH1_k127_5128860_23 PFAM CBS domain containing protein - - - 0.00000000001712 65.0
TH1_k127_5128860_3 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 5.019e-198 628.0
TH1_k127_5128860_4 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 567.0
TH1_k127_5128860_5 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 533.0
TH1_k127_5128860_6 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 445.0
TH1_k127_5128860_7 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 386.0
TH1_k127_5128860_8 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 352.0
TH1_k127_5128860_9 PFAM GTP-binding protein HSR1-related K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 346.0
TH1_k127_5130724_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 5.664e-213 672.0
TH1_k127_5130724_1 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000002331 239.0
TH1_k127_5130724_2 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000003917 205.0
TH1_k127_5130724_3 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000005602 203.0
TH1_k127_5199556_0 Protein-export membrane protein SecD K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 600.0
TH1_k127_5199556_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 302.0
TH1_k127_5199556_2 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000000000000000000002302 208.0
TH1_k127_5199556_3 Involved in protein export K03074 - - 0.000000000000000000000000000000000000000001135 158.0
TH1_k127_5199556_4 PFAM Thioredoxin K03671 - - 0.000000000000000000000000000000000001777 140.0
TH1_k127_5394490_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.371e-320 992.0
TH1_k127_5394490_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.987e-209 662.0
TH1_k127_5394490_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000006864 160.0
TH1_k127_5396414_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0 1036.0
TH1_k127_5396414_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 5e-324 1003.0
TH1_k127_5396414_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 426.0
TH1_k127_5396414_11 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 373.0
TH1_k127_5396414_12 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 327.0
TH1_k127_5396414_13 AAA domain K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 312.0
TH1_k127_5396414_14 PFAM TM2 domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 297.0
TH1_k127_5396414_15 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001528 280.0
TH1_k127_5396414_16 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005209 299.0
TH1_k127_5396414_17 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000001016 235.0
TH1_k127_5396414_18 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000000000000000000000000000005104 229.0
TH1_k127_5396414_19 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000000000000000000000000002228 221.0
TH1_k127_5396414_2 2Fe-2S iron-sulfur cluster binding domain - - - 3.323e-289 900.0
TH1_k127_5396414_20 PFAM TM2 domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000005675 205.0
TH1_k127_5396414_21 - - - - 0.0000000000000000000000000000000005805 134.0
TH1_k127_5396414_22 Glutaredoxin - - - 0.0000000000000000000000000000000009364 132.0
TH1_k127_5396414_23 - - - - 0.000000000000000000000000000000006323 130.0
TH1_k127_5396414_24 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000000000000003317 109.0
TH1_k127_5396414_25 - - - - 0.0000000000000000000021 96.0
TH1_k127_5396414_26 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000000000000003314 96.0
TH1_k127_5396414_27 - - - - 0.0000000000000001521 85.0
TH1_k127_5396414_28 bacterial-type flagellum-dependent cell motility - - - 0.0000000003446 69.0
TH1_k127_5396414_29 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000001186 68.0
TH1_k127_5396414_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 2.957e-274 846.0
TH1_k127_5396414_30 - - - - 0.00001183 59.0
TH1_k127_5396414_4 Uncharacterized protein conserved in archaea (DUF2114) - - - 2.902e-260 809.0
TH1_k127_5396414_5 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 1.155e-222 709.0
TH1_k127_5396414_6 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 618.0
TH1_k127_5396414_7 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 592.0
TH1_k127_5396414_8 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 585.0
TH1_k127_5396414_9 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 439.0
TH1_k127_5448446_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1015.0
TH1_k127_5448446_1 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 550.0
TH1_k127_5500354_0 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005412 376.0
TH1_k127_5500354_1 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000003063 207.0
TH1_k127_5500354_2 - - - - 0.0000000000001755 78.0
TH1_k127_5500354_3 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000005245 71.0
TH1_k127_5594713_0 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 510.0
TH1_k127_5594713_1 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 439.0
TH1_k127_5594713_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002104 262.0
TH1_k127_5594713_3 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000000002808 231.0
TH1_k127_5594713_4 Domain of unknown function (DUF3821) - - - 0.00000000000000000000000000000000000000000000006407 184.0
TH1_k127_5594713_5 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000006978 165.0
TH1_k127_5594713_6 PFAM Nitroreductase - - - 0.00000008421 55.0
TH1_k127_5594713_7 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000002 52.0
TH1_k127_561439_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 310.0
TH1_k127_561439_1 Belongs to the UPF0305 family - - - 0.000000000000000000000000000000000000000000000000000000000000000008851 230.0
TH1_k127_561439_2 Molybdopterin converting factor K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000426 155.0
TH1_k127_561439_3 Phosphate-starvation-inducible E - - - 0.0000000000000000000000004361 110.0
TH1_k127_561439_4 PFAM GCN5-related N-acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 0.000000000000000000007931 100.0
TH1_k127_5681506_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000001575 230.0
TH1_k127_5681506_1 Phosphate transport regulator K07220 - - 0.00000000000000000000000005675 108.0
TH1_k127_5681506_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000005491 105.0
TH1_k127_5681506_3 - - - - 0.000000000000000001123 93.0
TH1_k127_5681506_4 HD domain K01139 - 2.7.6.5,3.1.7.2 0.0000000000004653 76.0
TH1_k127_5681506_5 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000003321 64.0
TH1_k127_5696362_0 HI0933 family K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 487.0
TH1_k127_5696362_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 304.0
TH1_k127_5696362_2 PFAM multi antimicrobial extrusion protein MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008163 263.0
TH1_k127_5778712_0 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits K14572 - - 0.00009805 55.0
TH1_k127_5946546_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 480.0
TH1_k127_5946546_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 350.0
TH1_k127_5946546_2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 314.0
TH1_k127_5946546_3 PFAM ABC-1 domain protein K03688 - - 0.000000000000000000000000000000005975 132.0
TH1_k127_5946546_4 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000005323 128.0
TH1_k127_5946546_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000003692 97.0
TH1_k127_5960229_0 - - - - 0.000000000000000000001903 101.0
TH1_k127_5960229_1 - - - - 0.000000000000001004 79.0
TH1_k127_6067498_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645,K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 447.0
TH1_k127_6067498_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 439.0
TH1_k127_6067498_2 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 314.0
TH1_k127_6067498_3 Helix-turn-helix domain protein K03627 - - 0.0000000000003868 70.0
TH1_k127_6093550_0 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008681 321.0
TH1_k127_6093550_1 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007774 261.0
TH1_k127_6093550_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000001932 113.0
TH1_k127_6093550_3 Branched-chain amino acid transport system permease component K01998 - - 0.0002061 44.0
TH1_k127_6093760_0 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 606.0
TH1_k127_6093760_1 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 464.0
TH1_k127_6093760_2 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007081 424.0
TH1_k127_6093760_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005858 340.0
TH1_k127_6093760_4 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007101 266.0
TH1_k127_6093760_5 ATP-dependent DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000002943 219.0
TH1_k127_6093760_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000579 203.0
TH1_k127_6093760_7 dna ligase K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000008447 174.0
TH1_k127_6093760_8 PFAM thioesterase superfamily K02614 - - 0.0000000000000000000000000004014 119.0
TH1_k127_6120118_0 in RNase L inhibitor, RLI K06174 - - 3.436e-305 943.0
TH1_k127_6120118_1 Domain of unknown function (DUF814) - - - 8.439e-220 698.0
TH1_k127_6120118_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000002606 235.0
TH1_k127_6120118_3 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000001133 223.0
TH1_k127_6120118_4 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000009344 217.0
TH1_k127_6120118_5 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000000406 149.0
TH1_k127_6120118_6 RNase L inhibitor, RLI - - - 0.000000000000000000000003024 106.0
TH1_k127_6242786_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 357.0
TH1_k127_6242786_1 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 347.0
TH1_k127_6242786_2 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000006958 118.0
TH1_k127_6242786_3 PIN domain of ribonuclease K07060 - - 0.00000000000000000000005998 102.0
TH1_k127_6285195_0 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 450.0
TH1_k127_6285195_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 447.0
TH1_k127_6285195_2 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 418.0
TH1_k127_6285195_3 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 307.0
TH1_k127_6285195_4 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000004744 211.0
TH1_k127_6285195_5 hydrolase K04794 - 3.1.1.29 0.000000000000000000000000000000000000000000000002091 175.0
TH1_k127_6285195_6 PDGLE domain K02009 - - 0.0000000000000000000000000000000003542 134.0
TH1_k127_6285195_7 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.00000000002238 65.0
TH1_k127_6345155_0 PFAM GPR1 FUN34 yaaH family K07034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001815 277.0
TH1_k127_6345155_1 PFAM ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000001474 177.0
TH1_k127_6345155_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000002838 66.0
TH1_k127_6412670_0 PFAM Archaeal protein of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 481.0
TH1_k127_6412670_1 transcriptional regulator, ArsR family K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000001026 244.0
TH1_k127_6412670_2 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.0000000000000000000000000000000003767 138.0
TH1_k127_6412670_3 - K00960 - 2.7.7.6 0.0000000000000000000000000006552 112.0
TH1_k127_6412670_4 PFAM Cation K03498 - - 0.0000000000000002369 81.0
TH1_k127_6412670_5 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.00000000001337 65.0
TH1_k127_6412670_6 Protein of unknown function (DUF1059) - - - 0.0000004685 54.0
TH1_k127_6412670_7 - - - - 0.0005911 49.0
TH1_k127_6556220_0 NADPH-dependent FMN reductase K03809 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007614 315.0
TH1_k127_6556220_1 Proline dehydrogenase K00318 - - 0.00000000000000000004168 100.0
TH1_k127_6556220_3 - - - - 0.000000007226 61.0
TH1_k127_6569863_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0 1341.0
TH1_k127_6569863_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 436.0
TH1_k127_6569863_10 PFAM flavin reductase domain protein, FMN-binding - - - 0.000002599 50.0
TH1_k127_6569863_2 Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) K00878 - 2.7.1.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 359.0
TH1_k127_6569863_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 353.0
TH1_k127_6569863_4 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 331.0
TH1_k127_6569863_5 archaeosine synthase activity K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 328.0
TH1_k127_6569863_6 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 306.0
TH1_k127_6569863_7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001881 258.0
TH1_k127_6569863_8 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000003004 156.0
TH1_k127_6569863_9 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000000000000000001979 111.0
TH1_k127_6577220_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 6.792e-248 777.0
TH1_k127_6577220_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 427.0
TH1_k127_6577220_2 PFAM ABC-1 domain protein K03688 - - 0.00000000000000000000000000000000000000000000000002661 183.0
TH1_k127_6686812_0 helicase activity - - - 2.493e-247 788.0
TH1_k127_6686812_1 PFAM ribonuclease II K01147 - 3.1.13.1 3.458e-219 691.0
TH1_k127_6686812_2 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 395.0
TH1_k127_6686812_3 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 298.0
TH1_k127_6686812_4 SMART zinc finger, CDGSH-type domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000515 276.0
TH1_k127_6686812_5 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000000000000000000000001284 218.0
TH1_k127_6686812_6 - - - - 0.0000000000000005025 81.0
TH1_k127_6686812_8 tetratricopeptide repeat - - - 0.0000000393 58.0
TH1_k127_675116_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1310.0
TH1_k127_675116_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 1.011e-225 704.0
TH1_k127_675116_10 Ras family K06945 - - 0.000000000000000000000000000000000000000001367 162.0
TH1_k127_675116_11 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000003695 149.0
TH1_k127_675116_12 Uncharacterized protein conserved in archaea (DUF2124) - - - 0.000000000000000000000000000000000008379 137.0
TH1_k127_675116_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 555.0
TH1_k127_675116_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 328.0
TH1_k127_675116_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001331 282.0
TH1_k127_675116_5 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002462 275.0
TH1_k127_675116_6 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000251 235.0
TH1_k127_675116_7 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.0000000000000000000000000000000000000000000000000000000000001058 214.0
TH1_k127_675116_8 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000002221 215.0
TH1_k127_675116_9 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000000003858 190.0
TH1_k127_6785334_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1716.0
TH1_k127_6785334_1 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000002477 203.0
TH1_k127_6817327_0 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 539.0
TH1_k127_6817327_1 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 524.0
TH1_k127_6817327_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000927 430.0
TH1_k127_6817327_3 PFAM oxidoreductase nitrogenase, component 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 341.0
TH1_k127_6817327_4 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007929 289.0
TH1_k127_6817327_5 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007793 250.0
TH1_k127_6817327_6 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000000000001092 207.0
TH1_k127_690981_0 Sugar (and other) transporter K03446 - - 1.68e-233 731.0
TH1_k127_690981_1 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001075 271.0
TH1_k127_690981_2 HlyD membrane-fusion protein of T1SS K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000002819 228.0
TH1_k127_6963569_0 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 431.0
TH1_k127_6963569_1 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000459 225.0
TH1_k127_6963569_2 Domain of unknown function (DUF4349) - - - 0.000000000000000000000000000000000000000000000000000000000000002837 227.0
TH1_k127_6963569_3 PFAM SOUL heme-binding protein - - - 0.000000000000000000000000000000000000000000001137 173.0
TH1_k127_6963569_4 - - - - 0.000000000000000000000000000000000000000001456 167.0
TH1_k127_6963569_5 - - - - 0.000000000000000000001341 97.0
TH1_k127_7169044_0 PFAM Thiolase K00626 - 2.3.1.9 3.401e-210 658.0
TH1_k127_7169044_1 N-6 DNA Methylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 619.0
TH1_k127_7169044_10 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 351.0
TH1_k127_7169044_11 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006987 304.0
TH1_k127_7169044_12 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 290.0
TH1_k127_7169044_13 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 284.0
TH1_k127_7169044_14 Helix-turn-helix domain protein K07731 - - 0.000000000000000000000000000000000000000000000000000000000000000000003367 241.0
TH1_k127_7169044_15 Anaerobic ribonucleoside-triphosphate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000001847 226.0
TH1_k127_7169044_16 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000009049 217.0
TH1_k127_7169044_17 zinc finger - - - 0.000000000000000000000000000000000000000000000000000000000003472 214.0
TH1_k127_7169044_18 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000006711 199.0
TH1_k127_7169044_19 COG1246 N-acetylglutamate synthase and related acetyltransferases K00619 - 2.3.1.1 0.000000000000000000000000000000002271 129.0
TH1_k127_7169044_2 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 593.0
TH1_k127_7169044_20 Domain of unknown function (DUF1858) - - - 0.00000000000000000000000008603 107.0
TH1_k127_7169044_21 Ribonuclease K03469 - 3.1.26.4 0.0000000000000000000000005294 113.0
TH1_k127_7169044_22 Ferredoxin K05337 - - 0.00000000000000002917 83.0
TH1_k127_7169044_3 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 587.0
TH1_k127_7169044_4 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 538.0
TH1_k127_7169044_5 Uncharacterised conserved protein UCP033563 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 503.0
TH1_k127_7169044_6 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 467.0
TH1_k127_7169044_7 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009979 457.0
TH1_k127_7169044_8 Cysteine-rich small domain K08260 - 3.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 365.0
TH1_k127_7169044_9 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 348.0
TH1_k127_7203956_0 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 459.0
TH1_k127_7203956_1 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 309.0
TH1_k127_7203956_2 sugar phosphatases of the HAD superfamily K02566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002374 275.0
TH1_k127_7203956_3 PFAM PEGA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005369 276.0
TH1_k127_7203956_4 COG0518 GMP synthase - Glutamine amidotransferase domain K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000003916 203.0
TH1_k127_7203956_5 DEAD DEAH box helicase domain protein K06877 - - 0.0000000000000000000000000007509 119.0
TH1_k127_739137_0 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 437.0
TH1_k127_739137_1 Amidinotransferase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000002204 176.0
TH1_k127_739137_2 - - - - 0.00000000000000000000000000000000000000001644 160.0
TH1_k127_7431186_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005342 455.0
TH1_k127_7431186_1 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 379.0
TH1_k127_7431186_2 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000004472 199.0
TH1_k127_7431186_3 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000001345 153.0
TH1_k127_7431186_4 PFAM Yip1 domain - - - 0.0000000000000000000000000005133 121.0
TH1_k127_7431186_5 Alternative locus ID - - - 0.00000000000000000000000005582 119.0
TH1_k127_7431186_6 PBS lyase HEAT-like repeat - - - 0.00000000000000001249 89.0
TH1_k127_7431186_7 - - - - 0.0000000000001701 75.0
TH1_k127_7431186_8 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000003635 64.0
TH1_k127_7458137_0 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000006795 211.0
TH1_k127_7458137_1 protein involved in the oxidation of intracellular sulfur K07235,K07236 - - 0.00000000000000000000000000000000000000000000000000000000005064 220.0
TH1_k127_7458137_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000001346 182.0
TH1_k127_7458137_3 - K07112 - - 0.000000000000000000000000000000000000000000000002136 178.0
TH1_k127_7458137_4 Small multi-drug export protein - - - 0.00000000000000000000000000000003922 132.0
TH1_k127_7514935_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 8.243e-243 758.0
TH1_k127_7514935_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 335.0
TH1_k127_7514935_2 binds to the 23S rRNA K02921 - - 0.000000000000000000000000000000000000000008872 155.0
TH1_k127_7514935_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000000000000000000000000000000001856 151.0
TH1_k127_7514935_4 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000153 93.0
TH1_k127_7514935_5 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000000000002054 96.0
TH1_k127_7514935_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.0000000000000000000252 90.0
TH1_k127_7559064_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1844.0
TH1_k127_7559064_1 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.0 1261.0
TH1_k127_7559064_10 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 374.0
TH1_k127_7559064_11 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 329.0
TH1_k127_7559064_12 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002777 279.0
TH1_k127_7559064_13 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003768 255.0
TH1_k127_7559064_14 TIGRFAM methyltransferase FkbM family - - - 0.000000000000000000000000000000000000000000000000000000000000000003024 231.0
TH1_k127_7559064_15 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000004514 237.0
TH1_k127_7559064_16 Endonuclease related to archaeal Holliday junction resolvase - - - 0.0000000000000000000000000000000000000000000000000000000386 202.0
TH1_k127_7559064_17 Protein of unknown function (DUF432) K09149 - - 0.000000000000000000000000000000000000000000000000000001472 199.0
TH1_k127_7559064_18 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000000000000000002939 192.0
TH1_k127_7559064_19 PBS lyase K22221 - - 0.0000000000000000000000000000000000000000000000000003008 201.0
TH1_k127_7559064_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 3.94e-221 691.0
TH1_k127_7559064_20 - - - - 0.0000000000000000000000000000000000000009689 154.0
TH1_k127_7559064_21 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000001814 158.0
TH1_k127_7559064_22 - - - - 0.000000000000000000000000000000000000438 144.0
TH1_k127_7559064_23 Protein of unknown function DUF86 K07075 - - 0.000000000000000000000000006171 118.0
TH1_k127_7559064_24 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000003512 106.0
TH1_k127_7559064_25 - - - - 0.00000000000005505 79.0
TH1_k127_7559064_26 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000002957 74.0
TH1_k127_7559064_27 metallopeptidase activity - - - 0.000000000038 70.0
TH1_k127_7559064_28 Short repeat of unknown function (DUF308) - - - 0.0000000006067 67.0
TH1_k127_7559064_29 PFAM PBS lyase HEAT domain protein repeat-containing protein - - - 0.0003162 49.0
TH1_k127_7559064_3 TIGRFAM UbiD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 593.0
TH1_k127_7559064_4 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 539.0
TH1_k127_7559064_5 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 483.0
TH1_k127_7559064_6 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 423.0
TH1_k127_7559064_7 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 399.0
TH1_k127_7559064_8 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 381.0
TH1_k127_7559064_9 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000546 379.0
TH1_k127_7605760_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1037.0
TH1_k127_7605760_1 acid binding OB-fold tRNA helicase-type K07463 - - 8.625e-312 969.0
TH1_k127_7605760_10 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000003507 219.0
TH1_k127_7605760_11 B-block binding subunit of TFIIIC - - - 0.00000000000000000000000000000000000000000000002617 172.0
TH1_k127_7605760_12 adenyl ribonucleotide binding - - - 0.00000000000000000000000000000000000000000000009768 174.0
TH1_k127_7605760_13 - - - - 0.00000000000000000000000000000000005217 134.0
TH1_k127_7605760_14 PFAM Like-Sm ribonucleoprotein, core - - - 0.0000000000000000000000000000000006722 131.0
TH1_k127_7605760_15 PFAM Yip1 domain - - - 0.000000000000000000000000000000001935 138.0
TH1_k127_7605760_16 - - - - 0.0000000000000000000003779 100.0
TH1_k127_7605760_17 Hsp20/alpha crystallin family K13993 - - 0.00000072 56.0
TH1_k127_7605760_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 1.44e-246 764.0
TH1_k127_7605760_3 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 5.511e-206 644.0
TH1_k127_7605760_4 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009938 444.0
TH1_k127_7605760_5 PFAM Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 409.0
TH1_k127_7605760_6 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 367.0
TH1_k127_7605760_7 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006934 325.0
TH1_k127_7605760_8 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000007781 244.0
TH1_k127_7605760_9 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000001606 246.0
TH1_k127_7621110_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 2.368e-238 751.0
TH1_k127_7621110_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000007778 204.0
TH1_k127_7621110_2 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.0000000000000000000000000000000000000000000000000000009739 206.0
TH1_k127_7621110_3 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000002458 183.0
TH1_k127_7621110_4 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000002953 123.0
TH1_k127_7621110_5 - - - - 0.0000000000000001351 87.0
TH1_k127_763182_0 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000567 244.0
TH1_k127_763182_1 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000001159 220.0
TH1_k127_763182_2 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000002181 181.0
TH1_k127_763182_3 Sodium Bile acid symporter family K03453 - - 0.0000000000000000000000000000000000000008988 160.0
TH1_k127_763182_4 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000002573 136.0
TH1_k127_763182_5 - - - - 0.000000000000000000000000001658 116.0
TH1_k127_763182_6 - - - - 0.00000000000000001381 88.0
TH1_k127_7668783_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001225 285.0
TH1_k127_7668783_1 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000001486 222.0
TH1_k127_7668783_2 - - - - 0.00000000000000000000000000000000000000000000000005482 181.0
TH1_k127_7668783_3 - - - - 0.000000000000000000000000000000000000003182 148.0
TH1_k127_7673797_0 UV-endonuclease UvdE K13281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 415.0
TH1_k127_7673797_1 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000008503 265.0
TH1_k127_7673797_2 Flavodoxin-like fold K00355 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000002929 241.0
TH1_k127_7673797_3 PFAM ATP dependent DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000004099 214.0
TH1_k127_7673797_4 Phosphoribosyl transferase domain K07101 - - 0.0000000000000000000000000000000000000000000000000000005089 200.0
TH1_k127_7673797_5 double-stranded RNA binding K03685 - 3.1.26.3 0.00000000000000000000000000000000000000007986 159.0
TH1_k127_7673797_6 Protein of unknown function (DUF1211) - - - 0.0000000000000000000000000002264 123.0
TH1_k127_7673797_7 Belongs to the UPF0305 family - - - 0.0000000000000003482 78.0
TH1_k127_7697707_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1320.0
TH1_k127_7697707_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1250.0
TH1_k127_7697707_10 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 323.0
TH1_k127_7697707_11 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 315.0
TH1_k127_7697707_12 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 317.0
TH1_k127_7697707_13 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 316.0
TH1_k127_7697707_14 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 308.0
TH1_k127_7697707_15 Pyruvate kinase, alpha/beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 291.0
TH1_k127_7697707_16 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009644 283.0
TH1_k127_7697707_17 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000248 277.0
TH1_k127_7697707_18 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005188 242.0
TH1_k127_7697707_19 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.00000000000000000000000000000000000000000000000000000000000000001006 228.0
TH1_k127_7697707_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 3e-231 723.0
TH1_k127_7697707_20 PFAM regulatory protein, ArsR K07721 - - 0.000000000000000000000000000000000000000000000000000000000004558 213.0
TH1_k127_7697707_21 archaeal Zn-finger protein - - - 0.0000000000000000000000000000000000000000000000000000000002915 209.0
TH1_k127_7697707_22 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000000000000000000934 195.0
TH1_k127_7697707_23 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000002842 177.0
TH1_k127_7697707_24 Domain of unknown function (DUF371) K09738 - - 0.00000000000000000000000000000000000000000000001115 175.0
TH1_k127_7697707_25 PFAM thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000001955 174.0
TH1_k127_7697707_26 - - - - 0.0000000000000000000000000000000000000000000007282 168.0
TH1_k127_7697707_27 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000000215 171.0
TH1_k127_7697707_28 Belongs to the UPF0280 family K09740 - - 0.000000000000000000000000000000000000000001903 159.0
TH1_k127_7697707_29 - - - - 0.000000000000000000000000000000000000000002401 166.0
TH1_k127_7697707_3 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 9.543e-204 643.0
TH1_k127_7697707_30 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000004848 157.0
TH1_k127_7697707_31 - - - - 0.00000000000000000000000000000000006742 142.0
TH1_k127_7697707_32 - - - - 0.000000000000000000000000004947 114.0
TH1_k127_7697707_33 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.00000000000000000000000003116 111.0
TH1_k127_7697707_34 - - - - 0.0000000000000000000000004275 108.0
TH1_k127_7697707_35 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000001353 91.0
TH1_k127_7697707_36 - - - - 0.0000000000000001329 87.0
TH1_k127_7697707_37 Belongs to the small heat shock protein (HSP20) family - - - 0.000000000000001405 83.0
TH1_k127_7697707_38 - - - - 0.00000000599 60.0
TH1_k127_7697707_39 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000001086 55.0
TH1_k127_7697707_4 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 553.0
TH1_k127_7697707_5 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 549.0
TH1_k127_7697707_6 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 462.0
TH1_k127_7697707_7 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 423.0
TH1_k127_7697707_8 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 437.0
TH1_k127_7697707_9 ATP-grasp domain K06913 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007986 418.0
TH1_k127_7708604_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 601.0
TH1_k127_7708604_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 398.0
TH1_k127_7708604_2 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.0000000000000000000000002549 105.0
TH1_k127_7739761_0 Phosphate transport regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007022 508.0
TH1_k127_7739761_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 454.0
TH1_k127_7739761_2 COG1361 S-layer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 422.0
TH1_k127_7739761_3 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 416.0
TH1_k127_7739761_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 364.0
TH1_k127_7739761_5 Domain of unknown function DUF128 K21640 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 335.0
TH1_k127_7739761_6 PFAM transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000482 219.0
TH1_k127_7739761_8 PFAM Phage integrase family - - - 0.000000000000000004248 88.0
TH1_k127_7739761_9 - - - - 0.0000004119 54.0
TH1_k127_776710_0 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 550.0
TH1_k127_776710_1 peptidase M42 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 539.0
TH1_k127_776710_2 Belongs to the N(4) N(6)-methyltransferase family K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 374.0
TH1_k127_776710_3 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 362.0
TH1_k127_776710_4 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 284.0
TH1_k127_7806423_0 PFAM ABC transporter K00400 - - 2.916e-279 865.0
TH1_k127_7806423_1 SMART Elongator protein 3 MiaB NifB - - - 5.345e-255 799.0
TH1_k127_7806423_10 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 289.0
TH1_k127_7806423_11 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003969 246.0
TH1_k127_7806423_12 Uncharacterized protein conserved in archaea (DUF2112) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001845 243.0
TH1_k127_7806423_13 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001451 234.0
TH1_k127_7806423_14 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.0000000000000000000000000000000000000000000000000000000000008573 213.0
TH1_k127_7806423_15 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.00000000000000000000000000000000000000000000000000000000002406 209.0
TH1_k127_7806423_16 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000000000000000000000000001008 166.0
TH1_k127_7806423_17 - - - - 0.00001029 55.0
TH1_k127_7806423_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 1.003e-219 687.0
TH1_k127_7806423_3 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 602.0
TH1_k127_7806423_4 Belongs to the UPF0288 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009511 593.0
TH1_k127_7806423_5 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 488.0
TH1_k127_7806423_6 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 471.0
TH1_k127_7806423_7 PFAM elongation factor Tu domain 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 404.0
TH1_k127_7806423_8 His Kinase A (phospho-acceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 382.0
TH1_k127_7806423_9 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 347.0
TH1_k127_7935410_0 Protein of unknown function (DUF460) K09150 - - 9.525e-257 806.0
TH1_k127_7935410_1 PFAM TrkA-N domain protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 516.0
TH1_k127_7935410_2 PFAM PP-loop domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 387.0
TH1_k127_7935410_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 347.0
TH1_k127_7935410_4 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000006595 259.0
TH1_k127_7935410_5 RIO-like serine threonine protein kinase fused to N-terminal HTH domain K07179 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000001702 228.0
TH1_k127_7937141_0 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 2.428e-244 764.0
TH1_k127_7937141_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 437.0
TH1_k127_7937141_2 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 387.0
TH1_k127_7937141_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000001951 229.0
TH1_k127_7937141_4 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.0000000000000000000000000000000000000000000000000000000000000003509 224.0
TH1_k127_7950636_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307,K11928 - - 9.819e-237 742.0
TH1_k127_7950636_1 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 526.0
TH1_k127_7950636_2 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 476.0
TH1_k127_7950636_3 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000001449 108.0
TH1_k127_7968190_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001341 282.0
TH1_k127_7968190_1 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000000000000000004572 245.0
TH1_k127_7968190_2 involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000005003 226.0
TH1_k127_7968190_3 Cerebral endothelial cell adhesion molecule K11703 GO:0005575,GO:0005623,GO:0005886,GO:0007155,GO:0007159,GO:0008150,GO:0016020,GO:0022610,GO:0044464,GO:0071944,GO:0098609 2.4.1.50 0.00000000000000002251 92.0
TH1_k127_7988688_0 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 334.0
TH1_k127_7988688_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 321.0
TH1_k127_7988688_2 Domain of unknown function (DUF1805) - - - 0.00000000000000000001793 92.0
TH1_k127_7999970_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1324.0
TH1_k127_7999970_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1139.0
TH1_k127_7999970_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 318.0
TH1_k127_7999970_11 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 305.0
TH1_k127_7999970_12 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 290.0
TH1_k127_7999970_13 Phosphate transport regulator K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004014 272.0
TH1_k127_7999970_14 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000002323 215.0
TH1_k127_7999970_15 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000002937 188.0
TH1_k127_7999970_16 Belongs to the UPF0147 family K09721 - - 0.0000000000000000000000000000000000000000008215 157.0
TH1_k127_7999970_17 - - - - 0.000000000000000000000000000000000000000568 150.0
TH1_k127_7999970_18 Prokaryotic RING finger family 2 - - - 0.00000000000000000000000000002366 120.0
TH1_k127_7999970_19 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.00000000000000000000000001937 112.0
TH1_k127_7999970_2 PFAM AMP-dependent synthetase and ligase K00666 - - 1.022e-311 964.0
TH1_k127_7999970_20 - - - - 0.0000000000000001359 84.0
TH1_k127_7999970_21 - K02478 - 2.7.13.3 0.00000000000000103 80.0
TH1_k127_7999970_22 - K02478 - 2.7.13.3 0.000000000000005648 77.0
TH1_k127_7999970_23 defense response to virus K07061 - - 0.0000000000003067 76.0
TH1_k127_7999970_24 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.0002798 43.0
TH1_k127_7999970_3 DEAD DEAH box helicase domain protein K10896 - - 7.645e-297 929.0
TH1_k127_7999970_4 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 9.185e-282 874.0
TH1_k127_7999970_5 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 1.998e-201 632.0
TH1_k127_7999970_6 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 576.0
TH1_k127_7999970_7 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 494.0
TH1_k127_7999970_8 PFAM phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002248 486.0
TH1_k127_7999970_9 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 351.0
TH1_k127_804197_0 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 296.0
TH1_k127_804197_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001285 263.0
TH1_k127_804197_2 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000001496 197.0
TH1_k127_804197_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000002181 181.0
TH1_k127_804197_4 Small multi-drug export protein - - - 0.00000000000000000000000000000000000000000000000002747 188.0
TH1_k127_804197_5 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.000000000000000000000000000000000000000000000001822 182.0
TH1_k127_804197_6 - - - - 0.000000000000000000000000001651 117.0
TH1_k127_804197_7 - - - - 0.000000008316 59.0
TH1_k127_8081682_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 5.652e-195 618.0
TH1_k127_8081682_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 515.0
TH1_k127_8081682_2 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 329.0
TH1_k127_8081682_3 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000001509 150.0
TH1_k127_8228100_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 6.232e-252 781.0
TH1_k127_8228100_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 574.0
TH1_k127_8228100_10 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001976 239.0
TH1_k127_8228100_11 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000006232 224.0
TH1_k127_8228100_12 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000002993 216.0
TH1_k127_8228100_13 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000009864 216.0
TH1_k127_8228100_14 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000000000000000000000000003434 183.0
TH1_k127_8228100_15 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000006176 163.0
TH1_k127_8228100_16 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000002697 149.0
TH1_k127_8228100_17 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.00000000000000000000000000000002641 127.0
TH1_k127_8228100_18 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000000000005974 98.0
TH1_k127_8228100_2 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005503 482.0
TH1_k127_8228100_3 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 471.0
TH1_k127_8228100_4 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 425.0
TH1_k127_8228100_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009845 358.0
TH1_k127_8228100_6 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 351.0
TH1_k127_8228100_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 347.0
TH1_k127_8228100_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 287.0
TH1_k127_8228100_9 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 286.0
TH1_k127_8280580_0 Heat shock 70 kDa protein K04043 - - 8.887e-315 972.0
TH1_k127_8280580_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 2.856e-240 750.0
TH1_k127_8280580_10 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 338.0
TH1_k127_8280580_11 Functions by promoting the formation of the first peptide bond K03263 - - 0.00000000000000000000000000000000000000000000000000000000000006828 214.0
TH1_k127_8280580_12 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000000000000000000000000000000000000000002804 218.0
TH1_k127_8280580_13 COG1881 Phospholipid-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000009232 201.0
TH1_k127_8280580_14 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000004655 173.0
TH1_k127_8280580_15 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000009014 157.0
TH1_k127_8280580_16 Ribonuclease K03469 - 3.1.26.4 0.0000000000000000000000000000000009656 134.0
TH1_k127_8280580_17 - - - - 0.00000000000000000000000002594 110.0
TH1_k127_8280580_18 Peptidase dimerisation domain - - - 0.000000000000000004181 87.0
TH1_k127_8280580_2 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 5.612e-223 702.0
TH1_k127_8280580_3 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 571.0
TH1_k127_8280580_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 528.0
TH1_k127_8280580_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 463.0
TH1_k127_8280580_6 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 455.0
TH1_k127_8280580_7 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 368.0
TH1_k127_8280580_8 RNA methylase K07446 - 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007073 362.0
TH1_k127_8280580_9 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 344.0
TH1_k127_8396993_0 Uncharacterized membrane protein (DUF2298) - - - 1.321e-222 709.0
TH1_k127_8396993_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 4.329e-207 649.0
TH1_k127_8396993_10 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000000000009405 204.0
TH1_k127_8396993_11 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000000009235 199.0
TH1_k127_8396993_12 - - - - 0.00000000000000000000000000000000000000000000005062 183.0
TH1_k127_8396993_13 - - - - 0.000000000000000000000000000000000000000002305 163.0
TH1_k127_8396993_14 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.00000000000000000000000000000000001116 136.0
TH1_k127_8396993_15 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000002434 131.0
TH1_k127_8396993_16 Binds to the 23S rRNA K02896 - - 0.000000000000000000000000000009457 119.0
TH1_k127_8396993_17 Tetratricopeptide repeat - - - 0.0000000054 63.0
TH1_k127_8396993_18 TIGRFAM cation diffusion facilitator family transporter K16264 - - 0.000000713 53.0
TH1_k127_8396993_2 Involved in cell shape control K22222 - - 4.07e-200 629.0
TH1_k127_8396993_3 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 587.0
TH1_k127_8396993_4 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 505.0
TH1_k127_8396993_5 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 377.0
TH1_k127_8396993_6 PFAM Glycosyl transferase family 2 K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 314.0
TH1_k127_8396993_7 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003456 278.0
TH1_k127_8396993_8 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004045 276.0
TH1_k127_8396993_9 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000001716 237.0
TH1_k127_8417510_0 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 1.097e-255 798.0
TH1_k127_8417510_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 5.865e-235 734.0
TH1_k127_8417510_10 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000003093 237.0
TH1_k127_8417510_11 PFAM PUA domain containing protein K07575 - - 0.000000000000000000000000000000000000000000000000000000000000000009166 228.0
TH1_k127_8417510_12 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000902 216.0
TH1_k127_8417510_13 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000000000000000435 215.0
TH1_k127_8417510_14 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000006133 212.0
TH1_k127_8417510_15 Pfam:DUF552 K09152 - - 0.00000000000000000000000000000000000000000000000000000345 192.0
TH1_k127_8417510_16 PFAM phosphatidate cytidylyltransferase - - - 0.00000000000000000000000000000000000000000009656 166.0
TH1_k127_8417510_17 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000006725 153.0
TH1_k127_8417510_18 PFAM Like-Sm ribonucleoprotein, core K04796 - - 0.0000000000000000000000000000000000004615 142.0
TH1_k127_8417510_19 binds to the 23S rRNA K02922 - - 0.00000000000000000000000003433 108.0
TH1_k127_8417510_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.062e-230 721.0
TH1_k127_8417510_20 Zinc-ribbon containing domain - - - 0.000000000000000000002065 94.0
TH1_k127_8417510_21 - - - - 0.000000001762 58.0
TH1_k127_8417510_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 5.981e-223 701.0
TH1_k127_8417510_4 Belongs to the aspartokinase family K00928 - 2.7.2.4 2.41e-213 670.0
TH1_k127_8417510_5 DEAD DEAH box helicase K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 607.0
TH1_k127_8417510_6 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 521.0
TH1_k127_8417510_7 N-4 methylation of cytosine K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 504.0
TH1_k127_8417510_8 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 467.0
TH1_k127_8417510_9 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008203 274.0
TH1_k127_8429985_0 Pfam:DUF650 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 492.0
TH1_k127_8429985_1 transcriptional regulator, ArsR family K07013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008206 245.0
TH1_k127_8429985_2 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.00000000000000000000000000000000001649 142.0
TH1_k127_8429985_3 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.00000000000000000000000000001443 117.0
TH1_k127_8497118_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1035.0
TH1_k127_8497118_1 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 1.149e-224 701.0
TH1_k127_8497118_2 PFAM ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 285.0
TH1_k127_8497118_3 Ammonium Transporter K03320 - - 0.00000000000000009124 82.0
TH1_k127_8497118_4 - - - - 0.000000000000003105 81.0
TH1_k127_8497118_5 Protein of unknown function (DUF1294) - - - 0.000000000003674 70.0
TH1_k127_8556204_0 PFAM Aldehyde dehydrogenase K00130,K00135 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.1.8 1.263e-200 636.0
TH1_k127_8556204_1 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 568.0
TH1_k127_8556204_10 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000002547 190.0
TH1_k127_8556204_11 Yip1 domain - - - 0.0000000000000000000000000000000000000000000004563 175.0
TH1_k127_8556204_12 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000000000006992 163.0
TH1_k127_8556204_13 - - - - 0.0000000000000000001814 92.0
TH1_k127_8556204_14 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.0000003716 51.0
TH1_k127_8556204_2 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 559.0
TH1_k127_8556204_3 Anion transporter K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005736 481.0
TH1_k127_8556204_4 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 456.0
TH1_k127_8556204_5 Mediates influx of magnesium ions K03284 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 334.0
TH1_k127_8556204_6 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 308.0
TH1_k127_8556204_7 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 310.0
TH1_k127_8556204_8 TIGRFAM riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001743 262.0
TH1_k127_8556204_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000000000000002758 239.0
TH1_k127_8581349_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 8.56e-227 709.0
TH1_k127_8581349_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 7.326e-218 694.0
TH1_k127_8581349_10 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000000000000000006136 256.0
TH1_k127_8581349_11 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.00000000000000000000000000000000000000000000000000000000000000000006977 233.0
TH1_k127_8581349_12 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.000000000000000000000000000000000000000000000000000000000000000006929 231.0
TH1_k127_8581349_13 PFAM methyltransferase small K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000005623 216.0
TH1_k127_8581349_14 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.00000000000000000000000000000000000000000000000000000000007706 216.0
TH1_k127_8581349_15 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.000000000000000000000000000000000000000000000000349 176.0
TH1_k127_8581349_16 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000000000000000000000000000000000003427 171.0
TH1_k127_8581349_17 Belongs to the PDCD5 family K06875 - - 0.000000000000000000000000000000000000001509 150.0
TH1_k127_8581349_18 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.000000000000000000000000000000000000004873 149.0
TH1_k127_8581349_19 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000000000000000005764 140.0
TH1_k127_8581349_2 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 606.0
TH1_k127_8581349_20 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000000000006098 124.0
TH1_k127_8581349_21 CRS1_YhbY K07574 - - 0.00000000000000000000000001599 110.0
TH1_k127_8581349_22 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000000000000000000001058 102.0
TH1_k127_8581349_23 PFAM Ribosomal LX protein K02944 - - 0.0000000000000000000002388 97.0
TH1_k127_8581349_24 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000001125 86.0
TH1_k127_8581349_25 Tautomerase enzyme K01821 - 5.3.2.6 0.0000001558 56.0
TH1_k127_8581349_26 - - - - 0.0000006494 56.0
TH1_k127_8581349_3 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 558.0
TH1_k127_8581349_4 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 556.0
TH1_k127_8581349_5 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 471.0
TH1_k127_8581349_6 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 342.0
TH1_k127_8581349_7 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 292.0
TH1_k127_8581349_8 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 287.0
TH1_k127_8581349_9 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002809 282.0
TH1_k127_8607484_0 Belongs to the glutamate synthase family - - - 1.178e-211 668.0
TH1_k127_8607484_1 ZIP Zinc transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 332.0
TH1_k127_8607484_2 ATP10 protein - - - 0.000000000000000000000000000000000000006589 151.0
TH1_k127_8607910_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 8.499e-197 618.0
TH1_k127_8607910_1 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 502.0
TH1_k127_8607910_2 Co Zn Cd efflux system component K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 295.0
TH1_k127_8607910_3 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 282.0
TH1_k127_8607910_4 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.00000000000000000000000000000000000000006891 152.0
TH1_k127_863594_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 1.145e-295 916.0
TH1_k127_863594_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 374.0
TH1_k127_863594_10 - - - - 0.000002366 53.0
TH1_k127_863594_11 4Fe-4S binding domain K03616 - - 0.0007563 44.0
TH1_k127_863594_2 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 353.0
TH1_k127_863594_3 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 305.0
TH1_k127_863594_4 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000000000000000001609 196.0
TH1_k127_863594_5 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000000003153 186.0
TH1_k127_863594_6 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.0000000000000000000000000000000000000000005815 162.0
TH1_k127_863594_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.00000000000000000000000000558 112.0
TH1_k127_863594_8 - - - - 0.000000000000000000000005542 105.0
TH1_k127_863594_9 RNA-binding protein involved in rRNA processing K07569 - - 0.0000000000000000000253 93.0
TH1_k127_8647020_0 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 293.0
TH1_k127_8647020_1 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000005134 250.0
TH1_k127_8647020_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001056 231.0
TH1_k127_8647020_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000001651 185.0
TH1_k127_8647020_4 Protein conserved in bacteria - - - 0.0000006255 53.0
TH1_k127_8653670_0 Polyphosphate kinase 2 (PPK2) - - - 7.105e-194 618.0
TH1_k127_8653670_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 332.0
TH1_k127_8653670_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000004689 203.0
TH1_k127_8653670_3 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000004997 177.0
TH1_k127_8653670_4 Methyltransferase, type 11 - - - 0.0000000000000000000000000000000001965 134.0
TH1_k127_8653670_5 - - - - 0.0000000000002775 76.0
TH1_k127_8653670_6 PFAM YHS domain - - - 0.00000000001428 73.0
TH1_k127_8653670_8 Belongs to the glutamate synthase family - - - 0.000008774 49.0
TH1_k127_8671092_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003904 430.0
TH1_k127_8671092_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 370.0
TH1_k127_8671092_2 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 355.0
TH1_k127_8671092_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004062 252.0
TH1_k127_8671092_4 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001201 252.0
TH1_k127_8671092_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.000000000000000000000000000001879 123.0
TH1_k127_8671092_6 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.00000000000000000001099 92.0
TH1_k127_8671092_7 PFAM peptidase zinc-dependent K06974 - - 0.00000288 49.0
TH1_k127_8674668_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 477.0
TH1_k127_8674668_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 325.0
TH1_k127_8674668_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000001331 245.0
TH1_k127_8674668_3 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000000000000000000008171 211.0
TH1_k127_8674668_4 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000006446 192.0
TH1_k127_8674668_5 PFAM Uncharacterised protein family UPF0079, ATPase K06925 - - 0.00000000000000000000000000000002858 131.0
TH1_k127_8674668_6 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000006601 104.0
TH1_k127_8733361_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 4.646e-304 940.0
TH1_k127_8733361_1 Belongs to the dCTP deaminase family K01494,K09887 - 3.5.4.13,3.5.4.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 301.0
TH1_k127_8733361_2 PFAM Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000003878 229.0
TH1_k127_8733361_3 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000000000000001924 209.0
TH1_k127_8733361_4 META domain - - - 0.00000000000007158 74.0
TH1_k127_8733361_5 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.000006916 54.0
TH1_k127_8750414_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 612.0
TH1_k127_8750414_1 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 447.0
TH1_k127_8750414_10 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.0000000000000000000000001056 106.0
TH1_k127_8750414_11 nucleic acid binding OB-fold tRNA helicase-type - - - 0.0000000000000000000000006509 108.0
TH1_k127_8750414_12 - - - - 0.00000000000000000000003043 106.0
TH1_k127_8750414_13 PBS lyase HEAT-like repeat - - - 0.000000000000000006289 93.0
TH1_k127_8750414_2 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 430.0
TH1_k127_8750414_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K01823,K06989 - 1.4.1.21,5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009725 341.0
TH1_k127_8750414_4 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 325.0
TH1_k127_8750414_5 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000000000000000006465 204.0
TH1_k127_8750414_6 - - - - 0.00000000000000000000000000000000000000000000000000002395 193.0
TH1_k127_8750414_7 Transcriptional regulator K07108 - - 0.0000000000000000000000000000000005034 133.0
TH1_k127_8750414_8 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000000000000002086 115.0
TH1_k127_8750414_9 transcriptional regulators K03724 - - 0.00000000000000000000000001255 110.0
TH1_k127_8807561_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 3.359e-298 921.0
TH1_k127_8807561_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 1.19e-256 797.0
TH1_k127_8807561_10 - - - - 0.00000002158 58.0
TH1_k127_8807561_11 PFAM Uncharacterised protein family Ycf35 - - - 0.000001183 52.0
TH1_k127_8807561_2 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 5.799e-241 747.0
TH1_k127_8807561_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 1.124e-197 622.0
TH1_k127_8807561_4 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 387.0
TH1_k127_8807561_5 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 296.0
TH1_k127_8807561_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01657,K02500 GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 291.0
TH1_k127_8807561_7 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04068 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000009919 196.0
TH1_k127_8807561_8 - - - - 0.0000000000000000000000000000000003531 134.0
TH1_k127_8807561_9 - - - - 0.00000001063 63.0
TH1_k127_8810935_0 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 360.0
TH1_k127_8810935_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 321.0
TH1_k127_8810935_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000243 250.0
TH1_k127_8810935_3 META domain - - - 0.000000000000000000000000009409 119.0
TH1_k127_8856247_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 563.0
TH1_k127_8856247_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 537.0
TH1_k127_8856247_10 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000028 250.0
TH1_k127_8856247_11 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000002982 200.0
TH1_k127_8856247_12 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000008956 143.0
TH1_k127_8856247_13 chorismate mutase K04093 - 5.4.99.5 0.00000000000000000000000009389 110.0
TH1_k127_8856247_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 502.0
TH1_k127_8856247_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 428.0
TH1_k127_8856247_4 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 376.0
TH1_k127_8856247_5 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 356.0
TH1_k127_8856247_6 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000395 342.0
TH1_k127_8856247_7 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000467 320.0
TH1_k127_8856247_8 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 305.0
TH1_k127_8856247_9 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008929 277.0
TH1_k127_8964450_0 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 341.0
TH1_k127_8964450_1 PFAM Creatininase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000001312 259.0
TH1_k127_8964450_2 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000215 228.0
TH1_k127_8964450_3 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000008095 163.0
TH1_k127_8964450_4 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.00000000000000000000000000006163 117.0
TH1_k127_8964450_5 PhoD-like phosphatase K01113 - 3.1.3.1 0.0000000000000003646 89.0
TH1_k127_9007947_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 8.86e-240 753.0
TH1_k127_9007947_1 PFAM SufBD protein K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 576.0
TH1_k127_9007947_2 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 539.0
TH1_k127_9007947_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 513.0
TH1_k127_9007947_4 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 450.0
TH1_k127_9007947_5 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 403.0
TH1_k127_9007947_6 PFAM ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 395.0
TH1_k127_9007947_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001328 282.0
TH1_k127_9007947_8 PFAM cyclase family protein K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000002385 233.0
TH1_k127_9007947_9 - - - - 0.0000000000000000000000000000000000000000000000000004812 191.0
TH1_k127_9124647_0 LOR SDH bifunctional enzyme conserved - - - 1.026e-197 627.0
TH1_k127_9124647_1 SMART Elongator protein 3 MiaB NifB K06936 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 414.0
TH1_k127_9124647_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 322.0
TH1_k127_9124647_3 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000000000000000000000009512 231.0
TH1_k127_9129826_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 1.419e-235 738.0
TH1_k127_9129826_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 9.912e-214 668.0
TH1_k127_9129826_10 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000000005545 130.0
TH1_k127_9129826_11 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000000000006029 115.0
TH1_k127_9129826_12 Large family of predicted nucleotide-binding domains K07158 - - 0.000000000000000000000000007478 116.0
TH1_k127_9129826_13 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.00000000000000000000001273 103.0
TH1_k127_9129826_14 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000001682 94.0
TH1_k127_9129826_15 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000000002734 94.0
TH1_k127_9129826_2 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 514.0
TH1_k127_9129826_3 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 358.0
TH1_k127_9129826_4 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 323.0
TH1_k127_9129826_5 Domain of unknown function (DUF1917) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 297.0
TH1_k127_9129826_6 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 285.0
TH1_k127_9129826_7 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003451 254.0
TH1_k127_9129826_8 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000001381 227.0
TH1_k127_9129826_9 Belongs to the UPF0218 family K09735 - - 0.000000000000000000000000000000000000000000000000000001191 196.0
TH1_k127_919564_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1470.0
TH1_k127_919564_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 3.611e-264 819.0
TH1_k127_919564_10 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 394.0
TH1_k127_919564_11 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007407 377.0
TH1_k127_919564_12 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008268 338.0
TH1_k127_919564_13 Molybdenum cofactor synthesis domain K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 324.0
TH1_k127_919564_14 tRNAHis guanylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 289.0
TH1_k127_919564_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004179 253.0
TH1_k127_919564_16 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000005097 199.0
TH1_k127_919564_17 PFAM RDD domain containing protein - - - 0.000000000000000000000000000000000000000000000005821 177.0
TH1_k127_919564_18 membrane protein domain - - - 0.0000000000000000000000000000000000000002195 157.0
TH1_k127_919564_19 PFAM PRC-barrel domain - - - 0.0000000000000000000000000000000002769 133.0
TH1_k127_919564_2 Belongs to the IlvD Edd family K01687 - 4.2.1.9 6.119e-260 810.0
TH1_k127_919564_20 - K03686 - - 0.000000000000000000891 87.0
TH1_k127_919564_21 - - - - 0.0000000000000001664 80.0
TH1_k127_919564_3 SMART Elongator protein 3 MiaB NifB - - - 8.41e-238 747.0
TH1_k127_919564_4 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 2.057e-236 746.0
TH1_k127_919564_5 phosphoesterase RecJ domain protein - - - 1.362e-196 624.0
TH1_k127_919564_6 COG1668 ABC-type Na efflux pump, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 588.0
TH1_k127_919564_7 PFAM Aldehyde dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 572.0
TH1_k127_919564_8 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 511.0
TH1_k127_919564_9 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 514.0
TH1_k127_920437_0 - - - - 0.000000000000000000000000000000000000000000001616 173.0
TH1_k127_9412848_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.508e-308 959.0
TH1_k127_9412848_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit K01546 - 3.6.3.12 2.015e-218 691.0
TH1_k127_9412848_2 Protein tyrosine kinase - - - 0.000000000000000000001795 102.0
TH1_k127_9513626_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 511.0
TH1_k127_9513626_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001051 282.0
TH1_k127_9513626_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000006517 213.0
TH1_k127_9513626_3 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000004415 177.0
TH1_k127_9513626_4 - - - - 0.000000000000000422 83.0
TH1_k127_9513626_5 - K06193 - - 0.000000004119 58.0
TH1_k127_9617331_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 1.314e-285 885.0
TH1_k127_9617331_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 1.147e-214 673.0
TH1_k127_9617331_10 Predicted membrane protein (DUF2105) K14098 - - 0.00000000000000000000000000000000000000000000000000000000000143 214.0
TH1_k127_9617331_11 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000007435 186.0
TH1_k127_9617331_12 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaF K14097 - - 0.000000000000000000000000000000000000000000000009283 172.0
TH1_k127_9617331_13 - - - - 0.0000000000000000000000002097 105.0
TH1_k127_9617331_14 PFAM NiFe -hydrogenase-3-type complex Eha, EhaM K14104 - - 0.0000000000000000000003502 101.0
TH1_k127_9617331_15 PFAM molydopterin dinucleotide-binding region K00203 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 1.2.7.12 0.000000000000000000001685 98.0
TH1_k127_9617331_16 - K14100 - - 0.00001815 49.0
TH1_k127_9617331_17 - - - - 0.00004131 49.0
TH1_k127_9617331_2 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa K14106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 553.0
TH1_k127_9617331_3 PFAM respiratory-chain NADH dehydrogenase, subunit 1 K14101 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 370.0
TH1_k127_9617331_4 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 375.0
TH1_k127_9617331_5 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 300.0
TH1_k127_9617331_6 PFAM NiFe -hydrogenase-3-type complex Eha, membrane protein EhaH K14099 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001681 274.0
TH1_k127_9617331_7 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14105 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009982 256.0
TH1_k127_9617331_8 amino acid K16263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002423 264.0
TH1_k127_9617331_9 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K14107 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001165 247.0