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Overview

ID MAG03905
Name TH2_bin.33
Sample SMP0101
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Methylococcales
Family Methylomonadaceae
Genus
Species
Assembly information
Completeness (%) 80.84
Contamination (%) 2.33
GC content (%) 53.0
N50 (bp) 6,039
Genome size (bp) 2,138,078

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2189

Gene name Description KEGG GOs EC E-value Score Sequence
TH2_k127_1047075_0 Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 339.0
TH2_k127_1047075_1 PFAM Glycoside hydrolase, family 3, N-terminal K05349 - 3.2.1.21 0.00000000000000000000000000000000000000000000000434 175.0
TH2_k127_1047075_2 Protein of unknown function (DUF533) - - - 0.0000000000000000000000000000000000000000001726 168.0
TH2_k127_1047075_3 chaperone-mediated protein folding - - - 0.000000000005925 70.0
TH2_k127_1051726_0 PFAM alpha beta hydrolase K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 437.0
TH2_k127_1051726_1 Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 335.0
TH2_k127_1051726_2 Alkyl hydroperoxide reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003955 287.0
TH2_k127_1051726_3 Belongs to the carbohydrate kinase PfkB family - - - 0.0000000000000000000000000000000000000000000000000000000000004323 215.0
TH2_k127_1051726_4 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000001183 157.0
TH2_k127_105969_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding K01652 - 2.2.1.6 0.0 1026.0
TH2_k127_105969_1 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K01507,K15987 - 3.6.1.1 8.422e-291 908.0
TH2_k127_105969_2 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000005975 264.0
TH2_k127_105969_3 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000008017 201.0
TH2_k127_108499_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region K07640 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 399.0
TH2_k127_108499_1 SMART Signal transduction response regulator, receiver region K07662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 290.0
TH2_k127_108499_2 ATP-independent chaperone mediated protein folding - - - 0.00001395 55.0
TH2_k127_1089928_0 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 503.0
TH2_k127_1089928_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 304.0
TH2_k127_1089928_2 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000002324 215.0
TH2_k127_1089928_3 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000000000002831 196.0
TH2_k127_1089928_4 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000001205 119.0
TH2_k127_1131297_0 FeS assembly protein SufB K09014 - - 5.143e-217 677.0
TH2_k127_1131297_1 PFAM Polyphosphate kinase 2 - - - 1.058e-203 642.0
TH2_k127_1131297_2 TIGRFAM SUF system FeS cluster assembly, Rtf2-type regulator - - - 0.0000000000000000000000000000000000000000000000000000000001215 206.0
TH2_k127_1140935_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 308.0
TH2_k127_1140935_1 P-loop containing region of AAA domain K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009224 287.0
TH2_k127_1140935_2 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000001299 186.0
TH2_k127_1148410_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 6.128e-301 932.0
TH2_k127_1148410_1 Oxidoreductase NAD-binding domain K00523,K21832 - 1.17.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009938 434.0
TH2_k127_1148410_10 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000006408 166.0
TH2_k127_1148410_11 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 0.000000000000000016 82.0
TH2_k127_1148410_2 Bacterial-like globin K06886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008456 414.0
TH2_k127_1148410_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 326.0
TH2_k127_1148410_4 COG2206 HD-GYP domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005562 273.0
TH2_k127_1148410_5 Glycosyl transferases, related to UDP-glucuronosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006818 271.0
TH2_k127_1148410_6 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000004378 244.0
TH2_k127_1148410_7 Protein of unknown function (DUF3455) - - - 0.000000000000000000000000000000000000000000000004068 177.0
TH2_k127_1148410_8 Sporulation related domain - - - 0.0000000000000000000000000000000000000000006797 163.0
TH2_k127_1148410_9 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.000000000000000000000000000000000000000007523 176.0
TH2_k127_1152425_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006715 413.0
TH2_k127_1152425_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007227 312.0
TH2_k127_1152425_2 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000005323 257.0
TH2_k127_1152425_3 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000002879 238.0
TH2_k127_1152425_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000001088 227.0
TH2_k127_1152425_5 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000000000000000000000003307 186.0
TH2_k127_1152425_6 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 - - 0.0000000000000000000000005039 108.0
TH2_k127_1162619_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 539.0
TH2_k127_1162619_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 492.0
TH2_k127_1162619_2 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 443.0
TH2_k127_1162619_3 PFAM EAL domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004072 236.0
TH2_k127_1166688_0 Polysaccharide biosynthesis protein - - - 3.052e-242 756.0
TH2_k127_1166688_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 539.0
TH2_k127_1181707_0 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 1.154e-226 706.0
TH2_k127_1181707_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 482.0
TH2_k127_1181707_2 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000066 315.0
TH2_k127_1181707_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 304.0
TH2_k127_1188098_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1356.0
TH2_k127_1188098_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006018 272.0
TH2_k127_1188098_2 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000000002782 217.0
TH2_k127_1206869_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 1.903e-235 733.0
TH2_k127_1206869_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 3.798e-234 727.0
TH2_k127_1206869_10 Plant specific mitochondrial import receptor subunit TOM20 - - - 0.000000000000000000000000000000000000000000000000000001363 200.0
TH2_k127_1206869_11 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000000003717 146.0
TH2_k127_1206869_12 Sporulation related domain K03749 - - 0.00000000000000000000000004342 119.0
TH2_k127_1206869_13 - - - - 0.000000001509 59.0
TH2_k127_1206869_2 SurA N-terminal domain K03770 - 5.2.1.8 1.435e-221 703.0
TH2_k127_1206869_3 PFAM Mur ligase K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 557.0
TH2_k127_1206869_4 PFAM Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 485.0
TH2_k127_1206869_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008462 479.0
TH2_k127_1206869_6 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 417.0
TH2_k127_1206869_7 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 295.0
TH2_k127_1206869_8 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000261 212.0
TH2_k127_1206869_9 PFAM Colicin V production protein K03558 - - 0.000000000000000000000000000000000000000000000000000000113 199.0
TH2_k127_1222887_0 PFAM Transposase IS66 family K07484 - - 1e-323 994.0
TH2_k127_1222887_1 PFAM IS66 Orf2 like protein - - - 0.000000000000000000000000000000000000000000000000000000004693 202.0
TH2_k127_1222887_2 transposase activity - - - 0.0000000000000000000000000000000000000000000003669 167.0
TH2_k127_1222887_3 COG3039 Transposase and inactivated derivatives IS5 family K07481 - - 0.000000000000000000003403 96.0
TH2_k127_1227240_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 386.0
TH2_k127_1227240_1 DsrE/DsrF-like family K07235 - - 0.0000000000000000000000000000000000000000000000000003185 187.0
TH2_k127_1227240_2 Belongs to the DsrF TusC family K07236 - - 0.0000000000000000000001162 103.0
TH2_k127_1228123_0 BT1 family - - - 1.699e-250 783.0
TH2_k127_1228123_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 2.761e-207 651.0
TH2_k127_1228123_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 592.0
TH2_k127_1228123_3 Hydrogenase urease accessory protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000003218 94.0
TH2_k127_1228123_4 Tetratricopeptide repeat - - - 0.0001659 47.0
TH2_k127_1255400_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 530.0
TH2_k127_1255400_1 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008251 291.0
TH2_k127_1255400_2 - - - - 0.000000000000000000000000000000000000001509 150.0
TH2_k127_1255400_3 PFAM Transposase IS200 like K07491 - - 0.00000000000000001193 85.0
TH2_k127_1296497_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 7.365e-221 689.0
TH2_k127_1296497_1 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 2.037e-208 653.0
TH2_k127_1296497_2 PFAM Haloacid dehalogenase-like hydrolase K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 319.0
TH2_k127_1296497_3 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000000000000009347 202.0
TH2_k127_1301079_0 FAD linked oxidases, C-terminal domain K03777 - 1.1.5.12 7.283e-219 689.0
TH2_k127_1301079_1 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 548.0
TH2_k127_1301079_2 LppC putative lipoprotein K07121 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 402.0
TH2_k127_1301079_3 isomerase K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 323.0
TH2_k127_1301079_4 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000001621 231.0
TH2_k127_1301079_5 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000002239 149.0
TH2_k127_1301079_6 - - - - 0.00000000000000000000000000000000000001372 147.0
TH2_k127_1301079_7 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000000000004173 132.0
TH2_k127_1301079_8 Periplasmic or secreted lipoprotein - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000004405 116.0
TH2_k127_1324449_0 PFAM Binding-protein-dependent transport systems inner membrane component K02037 - - 0.0 1026.0
TH2_k127_1324449_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955 - 2.7.1.25,2.7.7.4 7.723e-306 942.0
TH2_k127_1324449_10 LysR substrate binding domain K03717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 409.0
TH2_k127_1324449_11 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 398.0
TH2_k127_1324449_12 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 358.0
TH2_k127_1324449_13 abc transporter atp-binding protein K02021 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 338.0
TH2_k127_1324449_14 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 315.0
TH2_k127_1324449_15 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000001041 243.0
TH2_k127_1324449_16 - - - - 0.00000000000000000000000000000000000000000000000000000000001566 222.0
TH2_k127_1324449_17 - - - - 0.0000000000001759 73.0
TH2_k127_1324449_18 - - - - 0.000000000001163 68.0
TH2_k127_1324449_19 membrane - - - 0.0000002183 63.0
TH2_k127_1324449_2 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 6.557e-263 813.0
TH2_k127_1324449_20 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.000008166 53.0
TH2_k127_1324449_21 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0004604 43.0
TH2_k127_1324449_3 Phosphate transport system permease protein K02038 - - 3.874e-252 788.0
TH2_k127_1324449_4 Outer membrane component of multidrug efflux pump - - - 5.477e-198 626.0
TH2_k127_1324449_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 8.504e-194 614.0
TH2_k127_1324449_6 Sulfate adenylyltransferase subunit 2 K00957 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 564.0
TH2_k127_1324449_7 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 497.0
TH2_k127_1324449_8 Toxic anion resistance family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 497.0
TH2_k127_1324449_9 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 432.0
TH2_k127_133182_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 6.67e-215 674.0
TH2_k127_133182_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000868 459.0
TH2_k127_133182_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004838 380.0
TH2_k127_133182_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 359.0
TH2_k127_133182_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19 0.00000000000000000000000000000000000000000000000000000000000001101 221.0
TH2_k127_133182_5 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000001229 185.0
TH2_k127_133182_6 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000001044 166.0
TH2_k127_133182_7 PFAM Phosphoribosyl-ATP pyrophosphohydrolase K01523 GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.6.1.31 0.000000000000000000000000000000000000000000002313 166.0
TH2_k127_133182_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000001006 112.0
TH2_k127_133182_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705 - 0.000000000002877 68.0
TH2_k127_1332321_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 7.116e-212 663.0
TH2_k127_1332321_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 565.0
TH2_k127_1332321_10 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000004592 94.0
TH2_k127_1332321_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 410.0
TH2_k127_1332321_3 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 411.0
TH2_k127_1332321_4 Uncharacterized protein conserved in bacteria (DUF2333) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 411.0
TH2_k127_1332321_5 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 286.0
TH2_k127_1332321_6 Protein of unknown function, DUF484 K09921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006916 281.0
TH2_k127_1332321_7 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007149 266.0
TH2_k127_1332321_8 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000007137 157.0
TH2_k127_1332321_9 Domain of unknown function (DUF4389) - - - 0.000000000000000000000000000007551 122.0
TH2_k127_1336247_0 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000001808 220.0
TH2_k127_1336247_1 Conserved Protein - - - 0.00000000000000000000000000000000000000000002076 168.0
TH2_k127_1336247_2 - - - - 0.000000000000000000000000000000003373 144.0
TH2_k127_1375885_0 Molecular chaperone. Has ATPase activity K04079 - - 0.0 1043.0
TH2_k127_1375885_1 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000000008812 162.0
TH2_k127_1375885_2 - - - - 0.0000000000000000000001105 99.0
TH2_k127_1375885_3 - - - - 0.000007517 48.0
TH2_k127_1397863_0 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 3.944e-245 764.0
TH2_k127_1397863_1 Penicillin-Binding Protein C-terminus Family - - - 2.171e-224 716.0
TH2_k127_1397863_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000006358 189.0
TH2_k127_1397863_3 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000000000000000006036 158.0
TH2_k127_1397863_4 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000007523 156.0
TH2_k127_1397863_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000327 136.0
TH2_k127_1410515_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 3.118e-241 754.0
TH2_k127_1410515_1 Flavin containing amine oxidoreductase K09835 - 5.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 609.0
TH2_k127_1410515_10 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.000001612 50.0
TH2_k127_1410515_2 May be involved in recombination K03554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 409.0
TH2_k127_1410515_3 PFAM YkuD domain K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 354.0
TH2_k127_1410515_4 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 309.0
TH2_k127_1410515_5 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000008292 262.0
TH2_k127_1410515_6 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000001703 218.0
TH2_k127_1410515_7 Uracil DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000000000232 189.0
TH2_k127_1410515_8 Alanine-zipper, major outer membrane lipoprotein - - - 0.0000000000000000000002003 99.0
TH2_k127_1410515_9 PFAM BFD-like 2Fe-2S -binding K02192 - - 0.000000000000000001995 86.0
TH2_k127_1413965_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.143e-235 743.0
TH2_k127_1413965_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004885 277.0
TH2_k127_1413965_2 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001439 273.0
TH2_k127_1413965_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004432 238.0
TH2_k127_1413965_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000004485 175.0
TH2_k127_1413965_5 Type III restriction enzyme, res subunit K01156 - 3.1.21.5 0.00000000000000000000000000000000000000000006597 162.0
TH2_k127_145179_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 4.098e-245 765.0
TH2_k127_145179_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 443.0
TH2_k127_145179_2 PFAM Cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 314.0
TH2_k127_145179_3 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000000001735 130.0
TH2_k127_145179_4 Class II Aldolase and Adducin N-terminal domain - - - 0.00000003183 56.0
TH2_k127_1471618_0 Type I restriction-modification system K03427 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 462.0
TH2_k127_1471618_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 391.0
TH2_k127_1471618_2 nucleic acid-binding protein contains PIN domain - - - 0.0000000000000000000000000000000000000533 146.0
TH2_k127_1471618_3 Bacterial antitoxin of type II TA system, VapB - - - 0.00000000000000000000005135 99.0
TH2_k127_1480641_0 Bacterial DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.0 1741.0
TH2_k127_1480641_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 443.0
TH2_k127_1480641_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 366.0
TH2_k127_1480641_3 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000001269 241.0
TH2_k127_1480641_4 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000017 229.0
TH2_k127_1480641_5 Belongs to the skp family K06142 - - 0.000000000000000000000000000000000000000000000000000000000002162 214.0
TH2_k127_1502332_0 TIGRFAM RNA helicase, ATP-dependent DEAH box, HrpA type K03578 - 3.6.4.13 0.0 1013.0
TH2_k127_1502332_1 esterase lipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005217 327.0
TH2_k127_1502332_2 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000001182 221.0
TH2_k127_1502332_3 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000433 63.0
TH2_k127_1502332_4 PFAM DNA methylase N-4 N-6 K07316 - 2.1.1.72 0.0000122 48.0
TH2_k127_1544859_0 S1, RNA binding domain K06959 - - 0.0 1122.0
TH2_k127_1544859_1 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004904 260.0
TH2_k127_1544859_2 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.0000000000000000000000000000000000000000000000000000000000002797 217.0
TH2_k127_1544859_3 - - - - 0.000000000000000000000041 105.0
TH2_k127_1582064_0 P-type ATPase K17686 - 3.6.3.54 2.878e-310 973.0
TH2_k127_1582064_1 - - - - 0.00000000000000000000000000000000000000003264 158.0
TH2_k127_1582064_2 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.00000003289 55.0
TH2_k127_1583318_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 5.809e-237 747.0
TH2_k127_1583318_1 glycyl-tRNA synthetase K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 574.0
TH2_k127_1583318_2 - - - - 0.0000000000000002013 83.0
TH2_k127_160663_0 DNA photolyase K01669 - 4.1.99.3 2.501e-212 670.0
TH2_k127_160663_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000801 381.0
TH2_k127_160663_2 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000000001248 226.0
TH2_k127_161586_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 5.473e-278 857.0
TH2_k127_161586_1 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000007916 219.0
TH2_k127_161586_2 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000005611 158.0
TH2_k127_161586_3 - - - - 0.00000000000000009939 84.0
TH2_k127_1643347_0 phosphoenolpyruvate carboxykinase (diphosphate) activity K20370 - 4.1.1.38 0.0 1628.0
TH2_k127_1643347_1 Putative ATP-dependent Lon protease K01338 - 3.4.21.53 0.0 1176.0
TH2_k127_1643347_2 mannose-ethanolamine phosphotransferase activity - - - 0.0 1157.0
TH2_k127_1643347_3 Transcriptional regulator - - - 3.231e-201 636.0
TH2_k127_1643347_4 Protein of unknown function (DUF1016) - - - 2.503e-197 619.0
TH2_k127_1643347_5 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003174 268.0
TH2_k127_1643347_6 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000333 192.0
TH2_k127_1643347_7 ATP-binding protein involved in virulence - - - 0.00000000000000000000000000001049 121.0
TH2_k127_1643347_8 ATP-binding protein involved in virulence - - - 0.00000000000000000000002342 101.0
TH2_k127_1676171_0 NMT1-like family K15576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 464.0
TH2_k127_1676171_1 PFAM response regulator receiver K07183 - - 0.0000000000000000000000000000000000000000000000000000000001355 209.0
TH2_k127_1676171_3 Peptidase C39 family K06992 - - 0.0000001698 57.0
TH2_k127_1692761_0 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00651 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000054 603.0
TH2_k127_1692761_1 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000002771 243.0
TH2_k127_1692761_2 deaminase zinc-binding - - - 0.0000000000000000000000000000000000000000000000000000000000005453 213.0
TH2_k127_1692761_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000003277 105.0
TH2_k127_1704628_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008946 515.0
TH2_k127_1704628_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009069 390.0
TH2_k127_1704628_2 MlaC protein K07323 - - 0.00000000000000000000000000000000000000000000000000000000000002914 220.0
TH2_k127_1704628_3 Cupin domain K11312 - - 0.00000000000000000000000000000000228 134.0
TH2_k127_1720463_0 UvrD-like helicase C-terminal domain K03654 - 3.6.4.12 3.485e-304 953.0
TH2_k127_172269_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 378.0
TH2_k127_172269_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 297.0
TH2_k127_1736165_0 haloacid dehalogenase-like hydrolase - - - 0.0 1096.0
TH2_k127_1736165_1 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005483 497.0
TH2_k127_1736165_2 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000004032 183.0
TH2_k127_176295_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 514.0
TH2_k127_176295_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 324.0
TH2_k127_176295_2 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 291.0
TH2_k127_176295_3 Prokaryotic glutathione synthetase, ATP-grasp domain K05844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 293.0
TH2_k127_176295_4 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000001078 243.0
TH2_k127_176295_5 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000493 224.0
TH2_k127_176295_6 Phage shock protein A K03615,K03969,K09749,K21471 - - 0.0000000000000000000001678 104.0
TH2_k127_176295_7 - - - - 0.000000007252 65.0
TH2_k127_176295_8 His Kinase A (phosphoacceptor) domain - - - 0.00000001652 56.0
TH2_k127_1791082_0 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003753 315.0
TH2_k127_1791082_1 DNA polymerase - - - 0.000000000000000000000000000000000000000000000000000003819 195.0
TH2_k127_1791082_2 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000000000000121 156.0
TH2_k127_1791082_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000002299 121.0
TH2_k127_1791082_4 Type III restriction enzyme, res subunit K01156 - 3.1.21.5 0.0001422 45.0
TH2_k127_1795444_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 - 1.12.1.2 1.247e-264 818.0
TH2_k127_1795444_1 Putative peptidoglycan binding domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 427.0
TH2_k127_1795444_2 hydrogenase maturation protease - - - 0.000000000000000000000000000000000000000000001314 171.0
TH2_k127_1795444_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000002064 109.0
TH2_k127_1815268_0 PFAM Glycosyl transferase, family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 444.0
TH2_k127_1815268_1 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 418.0
TH2_k127_1815268_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 324.0
TH2_k127_1815268_3 Peptidyl-prolyl cis-trans isomerase K01802,K03773 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000008403 228.0
TH2_k127_1815268_4 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001852 229.0
TH2_k127_1815268_5 Protein of unknown function (DUF3175) - - - 0.0000000000000000000000000000000000000002837 152.0
TH2_k127_1815268_6 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000003218 138.0
TH2_k127_1815268_7 - - - - 0.00000000000000000000000000007657 118.0
TH2_k127_1815268_8 MFS/sugar transport protein - - - 0.0000000000000000000000004243 106.0
TH2_k127_1815268_9 Transposase K07481 - - 0.00000397 49.0
TH2_k127_1825886_0 PFAM Isocitrate isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 550.0
TH2_k127_1825886_1 alcohol dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 451.0
TH2_k127_1825886_2 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 334.0
TH2_k127_1825886_3 Protein of unknown function (DUF3782) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004486 279.0
TH2_k127_1825886_4 Thioredoxin K07396 - - 0.0000000000000000000000000000000000000000000000000000001474 201.0
TH2_k127_1825886_5 - - - - 0.0000000000004617 76.0
TH2_k127_1836536_0 Cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 363.0
TH2_k127_1836536_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000002361 194.0
TH2_k127_1836536_2 response regulator - - - 0.000000000000000000000000000000000000000000000000001601 192.0
TH2_k127_1836536_3 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000000000000000001777 163.0
TH2_k127_1836536_4 signal transduction histidine kinase - - - 0.000000000000000000000000000000008466 137.0
TH2_k127_1836536_5 - - - - 0.00000007274 57.0
TH2_k127_1839191_0 PFAM Multicopper oxidase - - - 1.119e-272 851.0
TH2_k127_1839191_1 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 365.0
TH2_k127_1839191_2 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000004096 260.0
TH2_k127_1839702_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 456.0
TH2_k127_1839702_1 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005125 300.0
TH2_k127_1839702_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000002807 168.0
TH2_k127_183976_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1421.0
TH2_k127_1866418_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.51e-220 695.0
TH2_k127_1866418_1 Pyridoxal-phosphate dependent enzyme K01505 - 3.5.99.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 298.0
TH2_k127_1866418_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003493 246.0
TH2_k127_1866418_3 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000001255 121.0
TH2_k127_1866418_4 Belongs to the P-Pant transferase superfamily K06133 - - 0.0000000000000000134 86.0
TH2_k127_1886046_0 Cytochrome C and Quinol oxidase polypeptide I K04561 - 1.7.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 385.0
TH2_k127_1886046_1 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 377.0
TH2_k127_1886046_2 Cytochrome c K02305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 355.0
TH2_k127_1886046_3 - - - - 0.00000000000000000000000000000000000000000007719 162.0
TH2_k127_1905639_0 Thymidine phosphorylase K00758 - 2.4.2.4 4.245e-276 856.0
TH2_k127_1905639_1 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 414.0
TH2_k127_1905639_2 PFAM ATPase, F1 V1 A1 complex, alpha beta subunit, nucleotide-binding domain K02112 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000003982 265.0
TH2_k127_1905639_3 pfam nudix K08312 - - 0.000000000000000000000000000000000000000000000000000000000000000000003602 237.0
TH2_k127_1905639_4 protein conserved in bacteria K09906 - - 0.0000000000000000000000000000000000000000005642 164.0
TH2_k127_1905639_5 - - - - 0.00000000002792 73.0
TH2_k127_1917263_0 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 0.0 1455.0
TH2_k127_1917263_1 TIGRFAM phenazine biosynthesis K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004309 433.0
TH2_k127_1917263_2 TIGRFAM nitrite reductase NAD(P)H K00363 - 1.7.1.15 0.0000000000000000000000000000000000000000000004992 168.0
TH2_k127_1917263_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0000000000000000003721 87.0
TH2_k127_2091171_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 1.716e-301 935.0
TH2_k127_2091171_1 AI-2E family transporter K03548 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 451.0
TH2_k127_2091171_2 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 362.0
TH2_k127_2091171_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000268 272.0
TH2_k127_2153709_0 GHMP kinases N terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008059 443.0
TH2_k127_2153709_1 - K09717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 319.0
TH2_k127_2153709_2 subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000000000005694 200.0
TH2_k127_2229375_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1498.0
TH2_k127_2229375_1 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 515.0
TH2_k127_2229375_2 Membrane-bound serine protease (ClpP class) K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 491.0
TH2_k127_2229375_3 PFAM SPFH domain Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009019 358.0
TH2_k127_2229375_4 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 305.0
TH2_k127_2229375_5 - - - - 0.0000000000000000000000000000000000000001449 156.0
TH2_k127_2241680_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 361.0
TH2_k127_2241680_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 357.0
TH2_k127_2241680_2 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000000006612 187.0
TH2_k127_2241680_3 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000000000000000006659 139.0
TH2_k127_2245213_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 0.0 1172.0
TH2_k127_2245213_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 2.176e-195 625.0
TH2_k127_2245213_10 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004064 276.0
TH2_k127_2245213_11 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001329 258.0
TH2_k127_2245213_12 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000000000000006612 187.0
TH2_k127_2245213_13 - - - - 0.00000000000000000000000005918 111.0
TH2_k127_2245213_14 - - - - 0.000000006527 60.0
TH2_k127_2245213_2 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 593.0
TH2_k127_2245213_3 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 449.0
TH2_k127_2245213_4 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 434.0
TH2_k127_2245213_5 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 422.0
TH2_k127_2245213_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 402.0
TH2_k127_2245213_7 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 341.0
TH2_k127_2245213_8 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 321.0
TH2_k127_2245213_9 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 293.0
TH2_k127_2248076_0 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 4.894e-273 859.0
TH2_k127_2248076_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 3.57e-232 739.0
TH2_k127_2248076_2 Divalent ion tolerance protein K03926 - - 0.00000000000000000000000000000000000008257 144.0
TH2_k127_2248076_3 Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair - - - 0.000000000000000000000000004567 110.0
TH2_k127_2248076_5 reverse transcriptase - - - 0.0000000004525 63.0
TH2_k127_2261581_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 3.503e-267 831.0
TH2_k127_2261581_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 2.258e-198 630.0
TH2_k127_2261581_2 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 511.0
TH2_k127_2261581_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 289.0
TH2_k127_2261581_4 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 282.0
TH2_k127_2261581_5 YceI-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002109 239.0
TH2_k127_2261581_6 MucB/RseB C-terminal domain K03598 - - 0.0000000000000000000000000000000000000000000000000000000000000000005953 241.0
TH2_k127_2261581_7 Anti sigma-E protein RseA, N-terminal domain K03597 - - 0.00000000000008417 78.0
TH2_k127_2267505_0 Alginate export - - - 7.232e-252 784.0
TH2_k127_2267505_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 5.01e-221 698.0
TH2_k127_2267505_10 Bacterial regulatory helix-turn-helix protein, lysR family K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 346.0
TH2_k127_2267505_11 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 331.0
TH2_k127_2267505_12 PFAM EAL domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007709 271.0
TH2_k127_2267505_13 - - - - 0.000000000000000000000000000000000000000003372 157.0
TH2_k127_2267505_14 PFAM Integrase core domain - - - 0.0000000000000000000000000000001553 130.0
TH2_k127_2267505_15 domain protein - - - 0.000000000000000008292 85.0
TH2_k127_2267505_16 PFAM Integrase core domain - - - 0.00000000000000002315 85.0
TH2_k127_2267505_17 Small protein - - - 0.0000001749 55.0
TH2_k127_2267505_18 Protein of unknown function (DUF1698) - - - 0.000004968 59.0
TH2_k127_2267505_2 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 615.0
TH2_k127_2267505_3 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 565.0
TH2_k127_2267505_4 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 561.0
TH2_k127_2267505_5 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 497.0
TH2_k127_2267505_6 PFAM Bacterial extracellular solute-binding K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 496.0
TH2_k127_2267505_7 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 453.0
TH2_k127_2267505_8 ABC transporter permease protein K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 424.0
TH2_k127_2267505_9 sulfate transport system, permease K02046,K15496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 346.0
TH2_k127_2268626_0 AAA domain K07133 - - 2.215e-237 738.0
TH2_k127_2268626_1 Sucrose phosphate synthase, sucrose phosphatase-like K00696 - 2.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 419.0
TH2_k127_2268626_2 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006114 320.0
TH2_k127_2294410_0 Major Facilitator Superfamily - - - 1.476e-272 841.0
TH2_k127_2294410_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 6.969e-215 672.0
TH2_k127_2294410_2 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 396.0
TH2_k127_2294410_3 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 367.0
TH2_k127_2294410_4 PFAM N-acetylmuramoyl-L-alanine amidase K03806 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001552 272.0
TH2_k127_2294410_5 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006879 254.0
TH2_k127_2294410_6 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000000000000000000008602 217.0
TH2_k127_2294410_7 Iron-sulfur cluster insertion protein ErpA K15724 - - 0.000000000000000000000000000000000000000000000000000000000002165 209.0
TH2_k127_2294410_8 Major Facilitator Superfamily - - - 0.0000003307 54.0
TH2_k127_2351525_0 Carbohydrate phosphorylase - - - 0.0 1209.0
TH2_k127_2351525_1 Peptidase U32 K08303 - - 5.464e-259 801.0
TH2_k127_2351525_2 alcohol dehydrogenase K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 585.0
TH2_k127_2351525_3 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000004872 221.0
TH2_k127_2358125_0 Ammonium Transporter K03320 - - 1.046e-245 768.0
TH2_k127_2358125_1 PFAM Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000961 427.0
TH2_k127_2358125_2 Belongs to the P(II) protein family K04752 - - 0.00000000000000000000000000000000000000000000000000000000003842 207.0
TH2_k127_2358125_3 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04752 - - 0.0000000000000000000000000000000000000000000000000000001136 196.0
TH2_k127_2399832_0 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 1.778e-288 906.0
TH2_k127_2399832_1 AMIN domain K02666 - - 3.487e-204 659.0
TH2_k127_2399832_10 PFAM Pilus assembly protein PilP K02665 - - 0.00000000000000000000000000000000000000000000000000000000000000005562 226.0
TH2_k127_2399832_11 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000583 196.0
TH2_k127_2399832_12 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000000000000000002823 194.0
TH2_k127_2399832_13 Binds the 23S rRNA K02909 - - 0.0000000000000000000000000000000001005 133.0
TH2_k127_2399832_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 602.0
TH2_k127_2399832_3 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 551.0
TH2_k127_2399832_4 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 538.0
TH2_k127_2399832_5 Belongs to the bacterial glucokinase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 355.0
TH2_k127_2399832_6 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 344.0
TH2_k127_2399832_7 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001186 269.0
TH2_k127_2399832_8 PFAM Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003109 264.0
TH2_k127_2399832_9 PFAM Fimbrial assembly K02663 - - 0.00000000000000000000000000000000000000000000000000000000000000002024 229.0
TH2_k127_2404847_0 PFAM ATP-grasp fold - - - 7.953e-262 814.0
TH2_k127_2404847_1 Belongs to the HAD-like hydrolase superfamily K01101 - 3.1.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 407.0
TH2_k127_2404847_2 Protein of unknown function (DUF2817) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 371.0
TH2_k127_2404847_3 TIGRFAM dihydroxyacetone kinase, DhaK subunit K05878 - 2.7.1.121 0.000000000000000000000000000000000000000005184 156.0
TH2_k127_2404847_4 Ion channel - - - 0.000000000000000000000000000001305 125.0
TH2_k127_2406007_0 PFAM Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001218 250.0
TH2_k127_2406007_1 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000000000000000000000000000001744 233.0
TH2_k127_2406007_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000001504 125.0
TH2_k127_2406007_3 Protein of unknown function (DUF1614) - - - 0.00000000000000000000000002725 108.0
TH2_k127_240783_0 AMP-binding enzyme K01897 - 6.2.1.3 8.513e-249 791.0
TH2_k127_240783_1 Belongs to the RtcB family K14415 - 6.5.1.3 1.377e-243 758.0
TH2_k127_240783_2 RNA helicase K11927 - 3.6.4.13 7.052e-202 636.0
TH2_k127_240783_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 344.0
TH2_k127_240783_4 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003543 297.0
TH2_k127_240783_5 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000000000000000000000000000000008401 203.0
TH2_k127_240783_6 - - - - 0.00000000000000000001428 95.0
TH2_k127_240783_7 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000408 59.0
TH2_k127_2424755_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 3.648e-251 782.0
TH2_k127_2424755_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 4.39e-204 642.0
TH2_k127_2424755_10 PFAM Stringent starvation protein B K03600 - - 0.000000000000000000000000000000000000000000000000000001353 194.0
TH2_k127_2424755_11 Domain of unknown function (DUF1820) - - - 0.000000000000000000000000000000009087 129.0
TH2_k127_2424755_12 Belongs to the BolA IbaG family - - - 0.000000000000000001626 85.0
TH2_k127_2424755_13 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360 4.2.99.18 0.00000000002118 63.0
TH2_k127_2424755_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.065e-201 634.0
TH2_k127_2424755_3 Belongs to the UPF0276 family K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 447.0
TH2_k127_2424755_4 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 451.0
TH2_k127_2424755_5 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 345.0
TH2_k127_2424755_6 PFAM Glutathione S-transferase, N-terminal K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 332.0
TH2_k127_2424755_7 Cytochrome C1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 333.0
TH2_k127_2424755_8 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 323.0
TH2_k127_2424755_9 Putative DNA-binding domain K09929 - - 0.0000000000000000000000000000000000000000000000000000000000000000005349 241.0
TH2_k127_2438247_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 559.0
TH2_k127_2438247_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 518.0
TH2_k127_2438247_10 dehydratase - - - 0.000000000000000000000000000003892 124.0
TH2_k127_2438247_11 Rubredoxin - - - 0.0000000000000001481 78.0
TH2_k127_2438247_12 3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein) - - - 0.0000000000000307 76.0
TH2_k127_2438247_13 - - - - 0.000001689 53.0
TH2_k127_2438247_2 signal peptide peptidase SppA K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 443.0
TH2_k127_2438247_3 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 423.0
TH2_k127_2438247_4 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 365.0
TH2_k127_2438247_5 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 306.0
TH2_k127_2438247_6 Bacterial lipid A biosynthesis acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 301.0
TH2_k127_2438247_7 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 301.0
TH2_k127_2438247_8 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006887 269.0
TH2_k127_2438247_9 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000004744 215.0
TH2_k127_2456601_0 SMART Signal transduction response regulator, receiver region - - - 1.243e-237 741.0
TH2_k127_2456601_1 PFAM Sulphate transporter - - - 1.806e-234 736.0
TH2_k127_2456601_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 585.0
TH2_k127_2456601_3 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 571.0
TH2_k127_2456601_4 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000007664 110.0
TH2_k127_2456601_5 PFAM Sulphate transporter - - - 0.0000000000000000002154 88.0
TH2_k127_2500506_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 5.42e-242 756.0
TH2_k127_2500506_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 4.668e-201 636.0
TH2_k127_2500506_10 - - - - 0.00000000000000000000000000000002473 137.0
TH2_k127_2500506_11 Rubredoxin - - - 0.00000000000000000000000152 106.0
TH2_k127_2500506_2 COG0659 Sulfate permease and related transporters (MFS superfamily K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 543.0
TH2_k127_2500506_3 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 457.0
TH2_k127_2500506_4 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 412.0
TH2_k127_2500506_5 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 317.0
TH2_k127_2500506_6 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004909 242.0
TH2_k127_2500506_7 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000004257 174.0
TH2_k127_2500506_8 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000001576 167.0
TH2_k127_2500506_9 response to cobalt ion - - - 0.0000000000000000000000000000000000000000001649 163.0
TH2_k127_2512098_0 ATPase, AAA K07478 - - 1.707e-218 684.0
TH2_k127_2512098_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 542.0
TH2_k127_2512098_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 418.0
TH2_k127_2512098_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 377.0
TH2_k127_2512098_4 MOSC N-terminal beta barrel domain K07140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 342.0
TH2_k127_2512098_5 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003198 269.0
TH2_k127_2512098_6 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000001951 237.0
TH2_k127_2512098_7 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000004694 241.0
TH2_k127_2512098_8 2OG-Fe(II) oxygenase K07394 - - 0.00000000000000000000000000000000000000000000000000000000000000004776 229.0
TH2_k127_2515964_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1252.0
TH2_k127_2515964_1 Cytochrome c oxidase, subunit I K02274 - 1.9.3.1 4.855e-224 696.0
TH2_k127_2515964_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001018 286.0
TH2_k127_2515964_3 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000002275 230.0
TH2_k127_2515964_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.000002057 49.0
TH2_k127_2515964_5 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00005332 45.0
TH2_k127_254516_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 2.734e-278 860.0
TH2_k127_254516_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008592 562.0
TH2_k127_254516_2 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 522.0
TH2_k127_254516_3 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 481.0
TH2_k127_254516_4 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007622 376.0
TH2_k127_254516_5 PilZ domain - - - 0.00000000000000000000000000000000000000000000000001001 188.0
TH2_k127_254516_6 - - - - 0.000000000000000000000000000000000002243 140.0
TH2_k127_254516_7 Cytochrome c - - - 0.0000000000000000000000000000001162 128.0
TH2_k127_254516_8 Protein of unknown function (DUF433) - - - 0.0000000000000000000000000005141 114.0
TH2_k127_254516_9 Protein of unknown function (DUF2905) - - - 0.000000000000000000000000179 106.0
TH2_k127_2550457_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 5.9e-296 914.0
TH2_k127_2550457_1 May be involved in the transport of PQQ or its precursor to the periplasm K06136 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003097 526.0
TH2_k127_2550457_10 TIGRFAM coenzyme PQQ biosynthesis protein PqqD K06138 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.000000000000000000000000000000000001696 140.0
TH2_k127_2550457_11 Putative restriction endonuclease - - - 0.00000000000000000000000008798 109.0
TH2_k127_2550457_12 endonuclease III K01247 - 3.2.2.21 0.0000000000007842 69.0
TH2_k127_2550457_13 - - - - 0.00000001974 58.0
TH2_k127_2550457_2 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 462.0
TH2_k127_2550457_3 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 439.0
TH2_k127_2550457_4 ThiF family K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 372.0
TH2_k127_2550457_5 transcriptional regulator K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 347.0
TH2_k127_2550457_6 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000000000000000000000000004387 217.0
TH2_k127_2550457_7 TIGRFAM Coenzyme PQQ biosynthesis protein E K06139 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.0000000000000000000000000000000000000000000000000000000000002488 212.0
TH2_k127_2550457_8 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000000002803 181.0
TH2_k127_2550457_9 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000008045 164.0
TH2_k127_2586722_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 4.882e-300 929.0
TH2_k127_2586722_1 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 459.0
TH2_k127_2586722_2 PFAM Ferrous iron transporter, FeoA subunit K04758 - - 0.000000000000000000000000000003507 121.0
TH2_k127_2607678_0 Diguanylate cyclase - - - 6.063e-211 677.0
TH2_k127_2607678_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 499.0
TH2_k127_2607678_2 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region K20974 - 2.7.13.3 0.000000000000000000000008344 106.0
TH2_k127_2611958_0 Heat shock 70 kDa protein K04043 - - 0.0 1086.0
TH2_k127_2611958_1 TIGRFAM ATP-binding cassette protein, ChvD family - - - 0.0 1023.0
TH2_k127_2611958_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 GO:0006457,GO:0008150,GO:0009987 - 7.093e-197 618.0
TH2_k127_2611958_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 539.0
TH2_k127_2611958_4 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 406.0
TH2_k127_2611958_5 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 285.0
TH2_k127_2611958_6 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000001966 252.0
TH2_k127_2611958_7 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000000000000000000004267 220.0
TH2_k127_2614552_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 1.085e-248 786.0
TH2_k127_2614552_1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.00000000000000000000000000000000000000000001863 163.0
TH2_k127_2698782_0 PFAM Cytochrome d1 K19345 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 591.0
TH2_k127_2698782_1 PFAM Cytochrome - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 505.0
TH2_k127_2698782_2 Cytochrome C oxidase, cbb3-type, subunit III K19344 - - 0.000000000000000000000000000000001565 132.0
TH2_k127_2698782_3 PFAM Cytochrome C - - - 0.000000000000000000000000000000296 125.0
TH2_k127_2698782_4 - - - - 0.000007018 51.0
TH2_k127_2698782_5 PFAM Uncharacterised protein family UPF0150 - - - 0.000008183 49.0
TH2_k127_2707728_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 5.281e-304 947.0
TH2_k127_2707728_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 561.0
TH2_k127_2707728_2 COG2206 HD-GYP domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 460.0
TH2_k127_2836257_0 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 323.0
TH2_k127_2836257_1 AsnC-type helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003525 237.0
TH2_k127_2836257_2 overlaps another CDS with the same product name - - - 0.0000000000000000000000000000000000000000000000000000000000004547 215.0
TH2_k127_2836257_3 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000001465 210.0
TH2_k127_2836257_4 COGs COG0790 FOG TPR repeat SEL1 subfamily K07126 - - 0.00000000000000000000000000001066 122.0
TH2_k127_2855415_0 Glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1014.0
TH2_k127_2866753_0 Belongs to the peptidase S16 family - - - 0.0 1077.0
TH2_k127_2866753_1 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 604.0
TH2_k127_2866753_2 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 338.0
TH2_k127_2866753_3 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000006979 152.0
TH2_k127_2905323_0 - - - - 0.0000000000000000000000000000000000000000000000283 179.0
TH2_k127_2905323_1 sh3 domain protein K01448 - 3.5.1.28 0.0000000000000000000000000000000000000001255 155.0
TH2_k127_2905323_2 Lysozyme inhibitor LprI - - - 0.000000000000000000000000000000004431 130.0
TH2_k127_2905323_3 - - - - 0.0000002897 59.0
TH2_k127_2938994_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1069.0
TH2_k127_2938994_1 glutamate decarboxylase activity K01590 - 4.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 358.0
TH2_k127_2938994_2 PFAM amino acid-binding ACT domain protein - - - 0.0000000001624 67.0
TH2_k127_2960890_0 Orotidine 5'-phosphate decarboxylase / HUMPS family K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009733 604.0
TH2_k127_2960890_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 486.0
TH2_k127_2960890_2 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 317.0
TH2_k127_2960890_3 Putative inner membrane protein (DUF1819) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001338 244.0
TH2_k127_2960890_4 NlpB/DapX lipoprotein K07287 - - 0.000000000000000000000000000000000000365 152.0
TH2_k127_2966223_0 CoA binding domain K09181 - - 0.0 1394.0
TH2_k127_2966223_1 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 560.0
TH2_k127_2966223_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007303 543.0
TH2_k127_2966223_3 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 514.0
TH2_k127_2966223_4 Phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009564 419.0
TH2_k127_2966223_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000006599 177.0
TH2_k127_2966223_6 Protein of unknown function (DUF559) - - - 0.000000000000000000000000000000000001481 142.0
TH2_k127_2966223_7 Gram-negative-bacterium-type cell outer membrane assembly - - - 0.0000000006331 68.0
TH2_k127_2966223_8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.000000003511 60.0
TH2_k127_297022_0 PFAM Type II secretion system protein E K02454 - - 8.198e-228 719.0
TH2_k127_297022_1 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 363.0
TH2_k127_297022_2 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000003142 79.0
TH2_k127_2973139_0 pfam mofrl K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 521.0
TH2_k127_2973139_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 484.0
TH2_k127_2973139_2 PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008319 408.0
TH2_k127_2975900_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 552.0
TH2_k127_2975900_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 552.0
TH2_k127_2975900_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 397.0
TH2_k127_2975900_3 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007756 262.0
TH2_k127_2975900_4 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.000000000000000000000000000000000000002135 153.0
TH2_k127_3036430_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 473.0
TH2_k127_3036430_1 PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 420.0
TH2_k127_3036430_2 Pilus biogenesis K02656 - - 0.000000000000000000000000000000000000000000000000000002 200.0
TH2_k127_3047345_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.838e-238 746.0
TH2_k127_3047345_1 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 391.0
TH2_k127_3047345_2 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 392.0
TH2_k127_3047345_3 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0001815 45.0
TH2_k127_3101480_0 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 2.635e-229 734.0
TH2_k127_3114809_0 ZIP Zinc transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 473.0
TH2_k127_3114809_1 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 323.0
TH2_k127_3114809_2 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001588 268.0
TH2_k127_3114809_3 Phosphopantetheine attachment site - - - 0.0000000000000000000000000006725 114.0
TH2_k127_3114809_4 AMP-binding enzyme C-terminal domain - - - 0.000000000001294 74.0
TH2_k127_3137311_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 5.548e-229 714.0
TH2_k127_3137311_1 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0071704 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 561.0
TH2_k127_3137311_2 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 554.0
TH2_k127_3137311_3 Belongs to the RimK family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 424.0
TH2_k127_3137311_4 ATP:dephospho-CoA triphosphoribosyl transferase K05966 - 2.4.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 350.0
TH2_k127_3137311_5 PFAM Formaldehyde-activating enzyme K10713 - 4.2.1.147 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 297.0
TH2_k127_3137311_6 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000008429 226.0
TH2_k127_3137311_7 ATP-grasp domain - - - 0.00000000000000000000000001273 114.0
TH2_k127_3180155_0 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K05685 - - 5.811e-309 956.0
TH2_k127_3180155_1 PFAM Dihydropteroate synthase, DHPS - - - 3.38e-234 732.0
TH2_k127_3180155_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 480.0
TH2_k127_3180155_3 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 422.0
TH2_k127_3180155_4 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 370.0
TH2_k127_3180155_5 Protein of unknown function (DUF2927) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002688 284.0
TH2_k127_3180155_6 4-HFC-P synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000104 257.0
TH2_k127_3180155_7 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000837 250.0
TH2_k127_3180155_8 PFAM Flavoprotein - - - 0.0000008834 50.0
TH2_k127_3204151_0 ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 507.0
TH2_k127_3204151_1 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 385.0
TH2_k127_3204151_2 Lysozyme inhibitor LprI - - - 0.000000000000000000000000000000001797 132.0
TH2_k127_3204151_3 - - - - 0.00000000000002057 80.0
TH2_k127_3246464_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1013.0
TH2_k127_3246464_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 5.764e-201 637.0
TH2_k127_3246464_2 Permease YjgP YjgQ K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000201 262.0
TH2_k127_3246464_3 PFAM DNA polymerase III chi subunit, HolC K02339 - 2.7.7.7 0.0000000000000000000000000000000000000002686 153.0
TH2_k127_3259331_0 Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair K03580 - - 0.0 1061.0
TH2_k127_3259331_1 Chromate transporter - - - 7.358e-235 732.0
TH2_k127_3259331_2 Cytochrome b/b6/petB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007032 256.0
TH2_k127_3330576_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0 1045.0
TH2_k127_3330576_1 DNA helicase K03657 - 3.6.4.12 5.006e-215 676.0
TH2_k127_3343996_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370 - 1.7.5.1 0.0 2286.0
TH2_k127_3343996_1 4Fe-4S dicluster domain K16965,K17051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 4.253e-290 897.0
TH2_k127_3343996_2 nitrate reductase, gamma subunit K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 362.0
TH2_k127_3343996_3 Nitrate reductase K00373 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000155 260.0
TH2_k127_3343996_4 Alginate export - - - 0.00000000000000000000000002389 114.0
TH2_k127_335095_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 512.0
TH2_k127_335095_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000001932 85.0
TH2_k127_335095_2 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.0000000000000001153 81.0
TH2_k127_337137_0 2-oxoglutarate dehydrogenase, E1 component K00164 - 1.2.4.2 0.0 1386.0
TH2_k127_337137_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 3.408e-217 677.0
TH2_k127_337137_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 577.0
TH2_k127_337137_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 542.0
TH2_k127_337137_4 Domain in histone-like proteins of HNS family K03746 - - 0.0000000000000000000000000000006786 126.0
TH2_k127_337137_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000144 126.0
TH2_k127_3391445_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - 1.475e-237 745.0
TH2_k127_3391445_1 universal stress protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 352.0
TH2_k127_3391445_2 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001014 265.0
TH2_k127_3391445_3 - - - - 0.00000000000000000000000000000000000000000002516 162.0
TH2_k127_3392_0 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 302.0
TH2_k127_3392_1 C-terminal, D2-small domain, of ClpB protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 284.0
TH2_k127_3392_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000000000000000001315 200.0
TH2_k127_3392_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000005895 151.0
TH2_k127_3392_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000000005871 135.0
TH2_k127_3392_5 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00000000000000000000000008817 109.0
TH2_k127_3420394_0 Aminotransferase class I and II - - - 1.381e-195 616.0
TH2_k127_3420394_1 Nad-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 492.0
TH2_k127_3420394_2 PFAM Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001431 252.0
TH2_k127_3420394_3 phosphatase (DUF442) - - - 0.0000000000000000000000000000001564 127.0
TH2_k127_3420394_4 Superoxide dismutase K04565 - 1.15.1.1 0.0000000000000000000000000000003322 124.0
TH2_k127_3420394_5 - - - - 0.0000000000006915 71.0
TH2_k127_345039_0 PFAM Major Facilitator Superfamily K02575 - - 0.0 1462.0
TH2_k127_345039_1 Transcriptional regulator K13771 - - 0.00000000000000000000000000000000000000000000000000000001731 201.0
TH2_k127_345039_2 Alkaline phosphatase - - - 0.00000000000000000000000000000000000000000000000000003107 202.0
TH2_k127_3499146_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008853 472.0
TH2_k127_3499146_1 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 434.0
TH2_k127_3499146_2 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 373.0
TH2_k127_3499146_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 295.0
TH2_k127_3499146_4 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000133 171.0
TH2_k127_3499146_5 ribonuclease activity - - - 0.00000000000000000000000000000000000000006967 155.0
TH2_k127_3499146_6 - - - - 0.0000000000000001089 81.0
TH2_k127_3499146_7 - - - - 0.00000000000004329 74.0
TH2_k127_3529323_0 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007981 426.0
TH2_k127_3529323_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 315.0
TH2_k127_3529323_2 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000000000000000000008623 216.0
TH2_k127_3529323_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000003633 184.0
TH2_k127_3529323_4 Acyl- acyl-carrier-protein --UDP-N-acetylglucosamine O-acyltransferase K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000006232 158.0
TH2_k127_3529323_5 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.000000000000000000000000000000000001547 144.0
TH2_k127_3544541_0 Glycosyl hydrolase family 57 - - - 2.324e-312 971.0
TH2_k127_3544541_1 Phosphate transporter K03306 - - 2.751e-197 619.0
TH2_k127_3544541_10 - - - - 0.00000000000000002031 83.0
TH2_k127_3544541_2 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 609.0
TH2_k127_3544541_3 TIGRFAM formylmethanofuran dehydrogenase subunit C K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 370.0
TH2_k127_3544541_4 Mut7-C ubiquitin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007899 369.0
TH2_k127_3544541_5 Pit accessory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 340.0
TH2_k127_3544541_6 subunit D K02120 - - 0.00000000000000000000000000000000000000000000000000005117 194.0
TH2_k127_3544541_7 - - - - 0.00000000000000000000000000000000000000000000001077 176.0
TH2_k127_3544541_8 ATP synthase, subunit K02124 - - 0.00000000000000000000000001626 110.0
TH2_k127_3544541_9 DNA replication, synthesis of RNA primer K04066 - - 0.000000000000000000005054 97.0
TH2_k127_3595758_0 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 524.0
TH2_k127_3595758_1 Di-haem oxidoreductase, putative peroxidase K01201 - 3.2.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 321.0
TH2_k127_3595758_2 IgGFc binding protein - - - 0.0000000000000000000000000000000000000000000000639 196.0
TH2_k127_3666468_0 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K18005 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 387.0
TH2_k127_3666468_1 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.00000000000000000000000000000000000000000000000000000000111 204.0
TH2_k127_3666468_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000001439 158.0
TH2_k127_3667772_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1248.0
TH2_k127_3667772_1 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004174 278.0
TH2_k127_3667772_2 PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal K16137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003454 266.0
TH2_k127_3667772_3 - - - - 0.0000000000000000000000000000000306 129.0
TH2_k127_3667772_4 Protein of unknown function (DUF4242) - - - 0.00000003128 55.0
TH2_k127_3688621_0 SMART Glycosyl hydrolase, family 13, subfamily, catalytic region K05341 - 2.4.1.4 0.0 1196.0
TH2_k127_3688621_1 Sucrose phosphate synthase, sucrose phosphatase-like K00696 - 2.4.1.14 1.012e-309 957.0
TH2_k127_3688621_2 PFAM Carbohydrate purine kinase K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 430.0
TH2_k127_3688621_3 TIGRFAM HAD-superfamily hydrolase, subfamily IIB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 409.0
TH2_k127_3688621_4 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007208 253.0
TH2_k127_369445_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1163.0
TH2_k127_369445_1 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0008150,GO:0009273,GO:0009987,GO:0015929,GO:0016787,GO:0016798,GO:0042546,GO:0044085,GO:0071554,GO:0071840 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 442.0
TH2_k127_369445_10 Protein of unknown function (DUF1778) - - - 0.000000000000000001728 95.0
TH2_k127_369445_11 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000002684 73.0
TH2_k127_369445_12 Chromosome Partitioning - - - 0.00000001602 57.0
TH2_k127_369445_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 408.0
TH2_k127_369445_3 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 344.0
TH2_k127_369445_4 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K19696 - 2.4.2.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006587 341.0
TH2_k127_369445_5 PFAM Nucleotidyl transferase K00992 - 2.7.7.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 285.0
TH2_k127_369445_6 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002809 271.0
TH2_k127_369445_7 HIT domain - - - 0.00000000000000000000000000000000000000000000000000000000375 203.0
TH2_k127_369445_8 Protein of unknown function (DUF2380) - - - 0.000000000000000000000000000000000000000000000000000000006776 205.0
TH2_k127_369445_9 Dodecin K09165 - - 0.000000000000000000000000000001967 123.0
TH2_k127_3711420_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0 1219.0
TH2_k127_3711420_1 AAA-like domain K06915 - - 3.676e-303 935.0
TH2_k127_3711420_10 - - - - 0.000000000006733 74.0
TH2_k127_3711420_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 3.169e-250 772.0
TH2_k127_3711420_3 fructose-bisphosphate aldolase, class II, yeast E. coli subtype K01624 - 4.1.2.13 2.474e-195 614.0
TH2_k127_3711420_4 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 573.0
TH2_k127_3711420_5 PFAM Orotidine 5'-phosphate decarboxylase K08093 - 4.1.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 365.0
TH2_k127_3711420_6 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005735 309.0
TH2_k127_3711420_7 SIS domain K08094 - 5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 302.0
TH2_k127_3711420_8 - - - - 0.000000000000000000000000000000000000001089 156.0
TH2_k127_3711420_9 FeoC like transcriptional regulator - - - 0.0000000000000000000000000002829 117.0
TH2_k127_3724667_0 SPFH domain / Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 552.0
TH2_k127_3724667_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.000005661 52.0
TH2_k127_3726821_0 tRNA (guanine-N7-)-methyltransferase activity - - - 0.0 1048.0
TH2_k127_3726821_1 PFAM Aminotransferase, class I K00812,K02028,K12252 - 2.6.1.1,2.6.1.84,3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006306 567.0
TH2_k127_3726821_2 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008713 529.0
TH2_k127_3726821_3 Belongs to the peptidase S11 family K07262 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 299.0
TH2_k127_3726821_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000006546 245.0
TH2_k127_3726821_5 Domain of unknown function (DUF4160) - - - 0.00000000000000000000000000000000000000000000078 166.0
TH2_k127_3726821_6 Protein of unknown function (DUF2442) - - - 0.00000000000000000000000000000000000001621 146.0
TH2_k127_3726821_7 Nacht domain - - - 0.00000009685 55.0
TH2_k127_3726821_8 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0003855 43.0
TH2_k127_3751279_0 PFAM sulfatase K01130 - 3.1.6.1 0.0 1081.0
TH2_k127_3751279_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 503.0
TH2_k127_3751279_2 Protein involved in MetA-pathway of phenol - - - 0.00000000000000000000000000000000000000000000000000000000115 214.0
TH2_k127_3751279_3 Protein of unknown function (DUF3313) - - - 0.0000000000000000000000000000000000008475 149.0
TH2_k127_3751279_5 Glycine-zipper domain - - - 0.0000000000000000000000002161 111.0
TH2_k127_3751279_6 DDE superfamily endonuclease - - - 0.000000000000000000007513 96.0
TH2_k127_3769750_0 Belongs to the bacterial solute-binding protein 3 family K09969 - - 0.00000000000000000000000000000000000000000000000000000002691 206.0
TH2_k127_3769750_1 - - - - 0.000000000000000000000000000000000000000002988 158.0
TH2_k127_3769750_2 Domain of unknown function (DUF4136) - - - 0.00000000000000000000000000000001163 133.0
TH2_k127_3769750_3 Glycine-zipper domain - - - 0.00000000000000000000818 94.0
TH2_k127_3769750_4 META domain K09914 - - 0.000006097 50.0
TH2_k127_3777010_0 Belongs to the transketolase family - - - 0.0 1084.0
TH2_k127_3777010_1 Lycopene cyclase protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 519.0
TH2_k127_3777010_2 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 468.0
TH2_k127_3777010_3 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002921 441.0
TH2_k127_3777010_4 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.0000000000000000000000000000000000000002171 159.0
TH2_k127_3777010_5 - - - - 0.00000000000000000000004314 105.0
TH2_k127_3777010_6 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000001812 74.0
TH2_k127_3777010_7 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000008084 56.0
TH2_k127_383832_0 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 7.266e-226 708.0
TH2_k127_383832_1 epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 495.0
TH2_k127_383832_10 TIGRFAM Thioredoxin K03672 - 1.8.1.8 0.00000000000001568 75.0
TH2_k127_383832_11 - - - - 0.0000001468 61.0
TH2_k127_383832_2 DnaJ-class molecular chaperone K05516 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 437.0
TH2_k127_383832_3 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008928 435.0
TH2_k127_383832_4 Transporter associated domain K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 371.0
TH2_k127_383832_5 PFAM PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 346.0
TH2_k127_383832_6 - - - - 0.000000000000000000000000000000000000000000000000000000002857 205.0
TH2_k127_383832_7 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000000000000132 198.0
TH2_k127_383832_8 protein conserved in bacteria K09912 - - 0.000000000000000000000000000000000000000000000006954 177.0
TH2_k127_383832_9 MerR HTH family regulatory protein K18997 - - 0.00000000000000000000000000004652 119.0
TH2_k127_387396_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 7.623e-208 655.0
TH2_k127_387396_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K13049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 391.0
TH2_k127_387396_2 Amidohydrolase family - - - 0.0000000000000000000003409 98.0
TH2_k127_387396_3 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000001826 65.0
TH2_k127_3879264_0 Sulfate adenylyltransferase subunit 2 K00957 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004779,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 583.0
TH2_k127_3879264_1 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 529.0
TH2_k127_3879264_2 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.0000000000000000000000000000005285 126.0
TH2_k127_3879264_3 Transposase K07492 - - 0.000000000006265 65.0
TH2_k127_3887030_0 Peptidase, M48 K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 515.0
TH2_k127_3887030_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 423.0
TH2_k127_3887030_2 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004799 270.0
TH2_k127_3913305_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1094.0
TH2_k127_3913305_1 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 409.0
TH2_k127_3913305_2 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 - - 0.00000000000000000000000000000000000000000000000000000004108 196.0
TH2_k127_3913305_3 Belongs to the skp family K06142 - - 0.000000000000000001559 88.0
TH2_k127_3913431_0 Putative exonuclease SbcCD, C subunit - - - 0.0 1603.0
TH2_k127_3913431_1 Iron-containing alcohol dehydrogenase - - - 1.959e-220 687.0
TH2_k127_3913431_2 Uncharacterized protein conserved in bacteria N-term (DUF3322) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006269 591.0
TH2_k127_3913431_3 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 419.0
TH2_k127_3913431_4 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000000000000000003432 191.0
TH2_k127_3913431_5 Domain of unknown function (DUF4194) - - - 0.0000000000000000000000000000000000000001732 151.0
TH2_k127_3913431_6 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000005248 136.0
TH2_k127_3970706_0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region - - - 0.0 1337.0
TH2_k127_3970706_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 0.0 1150.0
TH2_k127_3970706_10 TIGRFAM lipopolysaccharide heptosyltransferase I K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 447.0
TH2_k127_3970706_11 Oxygen tolerance - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 389.0
TH2_k127_3970706_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009546 349.0
TH2_k127_3970706_13 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001111 260.0
TH2_k127_3970706_14 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000004471 206.0
TH2_k127_3970706_15 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000000000000378 175.0
TH2_k127_3970706_2 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 5.678e-270 842.0
TH2_k127_3970706_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 3.579e-230 718.0
TH2_k127_3970706_4 Proton-conducting membrane transporter K00342 - 1.6.5.3 8.788e-224 705.0
TH2_k127_3970706_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009278 597.0
TH2_k127_3970706_6 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 559.0
TH2_k127_3970706_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 558.0
TH2_k127_3970706_8 TIGRFAM Lipopolysaccharide heptosyltransferase II K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 476.0
TH2_k127_3970706_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 447.0
TH2_k127_399190_0 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 1.413e-215 678.0
TH2_k127_399190_1 Lipoprotein - - - 0.0000000000000000000000000002291 121.0
TH2_k127_4019570_0 TonB dependent receptor K16092 - - 1.969e-225 714.0
TH2_k127_4019570_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 448.0
TH2_k127_4087793_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003824,GO:0004654,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.8 0.0 1082.0
TH2_k127_4087793_1 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000006509 126.0
TH2_k127_410087_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 5.026e-228 713.0
TH2_k127_410087_1 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 413.0
TH2_k127_410087_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006344 294.0
TH2_k127_410087_3 - - - - 0.0000006943 58.0
TH2_k127_415918_0 Helix-hairpin-helix containing domain - - - 0.0 1287.0
TH2_k127_415918_1 methyltransferase activity K21310 - 2.1.1.334 0.0000000000000000000000004602 106.0
TH2_k127_4175516_0 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 506.0
TH2_k127_4175516_1 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000005222 211.0
TH2_k127_4219704_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 3.409e-215 674.0
TH2_k127_4219704_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 477.0
TH2_k127_4219704_2 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.0000000000000000004486 91.0
TH2_k127_4219704_3 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000002526 64.0
TH2_k127_4236437_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 2.383e-213 665.0
TH2_k127_4236437_1 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 557.0
TH2_k127_4236437_2 PFAM Alpha-D-phosphohexomutase, alpha beta alpha domain I K01840 - 5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 553.0
TH2_k127_4236437_3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003168 531.0
TH2_k127_4236437_4 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 470.0
TH2_k127_4236437_5 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 391.0
TH2_k127_4236437_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001878 258.0
TH2_k127_4236437_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001448 244.0
TH2_k127_4236437_8 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.00002443 47.0
TH2_k127_4251505_0 PFAM Rhodanese-like K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 370.0
TH2_k127_4251505_1 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 343.0
TH2_k127_4251505_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0000000000000000000000000000000000000000000000002632 178.0
TH2_k127_4251505_3 Belongs to the SOS response-associated peptidase family - - - 0.00000004988 54.0
TH2_k127_4251505_4 Major Facilitator Superfamily - - - 0.0000003954 53.0
TH2_k127_4311246_0 PFAM Major Facilitator Superfamily K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 512.0
TH2_k127_4311246_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 471.0
TH2_k127_4311246_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 440.0
TH2_k127_4311246_3 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 327.0
TH2_k127_4311246_4 Citrate transporter - - - 0.000000000000000000001163 94.0
TH2_k127_4378136_0 Carbamoyltransferase K00612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 409.0
TH2_k127_4378136_1 Asparagine synthase - - - 0.0000000000001231 80.0
TH2_k127_4382733_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 0.0 1395.0
TH2_k127_4382733_1 gag-polyprotein putative aspartyl protease - - - 0.000000000000000000000001276 107.0
TH2_k127_4394469_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 570.0
TH2_k127_4394469_1 Bacterial regulatory protein, Fis family K02481,K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009282 539.0
TH2_k127_4394469_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 403.0
TH2_k127_4394469_3 - - - - 0.00000000000000000000000522 108.0
TH2_k127_4394469_4 Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues K08068 - 3.2.1.183 0.0000002099 53.0
TH2_k127_4456885_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1075.0
TH2_k127_4456885_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000000000000000001096 113.0
TH2_k127_4456885_2 Protein of unknown function (DUF455) - - - 0.0000000000000000008298 87.0
TH2_k127_4456885_3 PFAM PilT protein, N-terminal - - - 0.0005003 45.0
TH2_k127_4460383_0 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 8.294e-205 662.0
TH2_k127_4460383_1 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 405.0
TH2_k127_4460383_2 PFAM Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000003391 103.0
TH2_k127_4478187_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 2388.0
TH2_k127_4478187_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2374.0
TH2_k127_4478187_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1236.0
TH2_k127_4478187_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 398.0
TH2_k127_4478187_4 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000898 271.0
TH2_k127_4478187_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002666 263.0
TH2_k127_4478187_6 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000008574 234.0
TH2_k127_4478187_7 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000000000007343 171.0
TH2_k127_4478187_8 translation elongation factor activity K02358 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000008298 85.0
TH2_k127_4478187_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000001998 61.0
TH2_k127_4511308_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 2.469e-317 978.0
TH2_k127_4511308_1 ATP-dependent Clp protease, ATP-binding subunit ClpA K03694 - - 4.394e-277 861.0
TH2_k127_4511308_2 Succinate dehydrogenase fumarate reductase K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 440.0
TH2_k127_4511308_3 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000000000000001402 181.0
TH2_k127_4511308_4 Succinate dehydrogenase, cytochrome b556 subunit K00241 - - 0.00000000000000000000000000000692 122.0
TH2_k127_4511308_5 succinate dehydrogenase, hydrophobic membrane anchor K00242 - - 0.0000000000000000008066 91.0
TH2_k127_4511308_6 Flavinator of succinate dehydrogenase K09159 - - 0.0000000000000002151 82.0
TH2_k127_4511308_7 - K19168 - - 0.0000001717 58.0
TH2_k127_4526971_0 it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction K03656 - 3.6.4.12 0.0 1035.0
TH2_k127_4526971_1 Ion channel - - - 0.00000000000000000000000000000000000005158 151.0
TH2_k127_4528396_0 Cytochrome c-type biogenesis protein Ccs1 ResB K07399 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 615.0
TH2_k127_4528396_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 464.0
TH2_k127_4528396_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 293.0
TH2_k127_4528396_3 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 287.0
TH2_k127_4528396_4 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000000000000000000000000000000001452 242.0
TH2_k127_4528396_5 Transmembrane protein 260 - - - 0.0000000000000000000000000000001082 142.0
TH2_k127_4543193_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 5.314e-248 772.0
TH2_k127_4543193_1 Sulfotransferase family - - - 0.000000000000000000000000000000000002265 147.0
TH2_k127_4543193_2 PilZ domain - - - 0.0000000000001144 77.0
TH2_k127_4543193_3 AAA domain K07028 - - 0.00008558 47.0
TH2_k127_4572053_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0 1079.0
TH2_k127_4572053_1 4Fe-4S dicluster domain K00124 - - 4.328e-261 813.0
TH2_k127_4572482_0 Histidine Phosphotransfer domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008497 291.0
TH2_k127_4572482_1 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000006598 208.0
TH2_k127_4599659_0 Glycosyl hydrolases family 17 - - - 2.568e-208 666.0
TH2_k127_4599659_1 HupE / UreJ protein K03192 - - 0.00000000000004111 75.0
TH2_k127_4599659_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000001321 70.0
TH2_k127_4601604_0 Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family K03308 - - 5.497e-210 661.0
TH2_k127_4601604_1 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000374 263.0
TH2_k127_4601604_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000004214 226.0
TH2_k127_4601604_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000000000000004871 124.0
TH2_k127_4601604_4 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000000000000000000004667 113.0
TH2_k127_4601604_5 DDE superfamily endonuclease - - - 0.0001006 46.0
TH2_k127_4606752_0 type IV, pilus assembly K02652 - - 1.095e-264 825.0
TH2_k127_4606752_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 606.0
TH2_k127_4606752_2 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006913 332.0
TH2_k127_4621493_0 Domain of unknown function (DUF4478) K06966 - 3.2.2.10 1.704e-257 798.0
TH2_k127_4621493_1 POT family K03305 - - 1.022e-196 622.0
TH2_k127_4621493_10 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000005047 158.0
TH2_k127_4621493_11 Oxygen tolerance - - - 0.0000000000000000000000000000003832 128.0
TH2_k127_4621493_12 - - - - 0.00000000001114 69.0
TH2_k127_4621493_13 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.0000000000466 65.0
TH2_k127_4621493_2 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 605.0
TH2_k127_4621493_3 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 520.0
TH2_k127_4621493_4 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 466.0
TH2_k127_4621493_5 short-chain dehydrogenase reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 396.0
TH2_k127_4621493_6 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 358.0
TH2_k127_4621493_7 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001194 278.0
TH2_k127_4621493_8 Cupin domain - - - 0.000000000000000000000000000000000000000000000009246 173.0
TH2_k127_4621493_9 Domain of unknown function (DUF4381) - - - 0.000000000000000000000000000000000000000000001627 171.0
TH2_k127_4648166_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1103.0
TH2_k127_4648166_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1090.0
TH2_k127_4648166_10 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000000000000000006391 116.0
TH2_k127_4648166_11 - - - - 0.000001943 49.0
TH2_k127_4648166_2 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1087.0
TH2_k127_4648166_3 PFAM Aminotransferase, class I K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 606.0
TH2_k127_4648166_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 565.0
TH2_k127_4648166_5 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004562 272.0
TH2_k127_4648166_6 PFAM HTH transcriptional regulator, MerR - - - 0.000000000000000000000000000000000000000000000000000000000000002711 218.0
TH2_k127_4648166_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000000002149 192.0
TH2_k127_4648166_8 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000002714 147.0
TH2_k127_4648166_9 - - - - 0.00000000000000000000000000009498 120.0
TH2_k127_4652889_0 Dynamin family - - - 5.721e-303 938.0
TH2_k127_4652889_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 5.332e-253 787.0
TH2_k127_4652889_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009039 536.0
TH2_k127_4652889_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 502.0
TH2_k127_4652889_4 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 314.0
TH2_k127_4654062_0 Trypsin K04771 - 3.4.21.107 4.904e-236 731.0
TH2_k127_4654062_1 Peptidase dimerisation domain - - - 6.083e-203 632.0
TH2_k127_4655034_0 FtsX-like permease family K02004 - - 3.465e-207 650.0
TH2_k127_4655034_1 PFAM Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 472.0
TH2_k127_4655034_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 430.0
TH2_k127_4655034_3 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 361.0
TH2_k127_4655034_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000006241 175.0
TH2_k127_466423_0 PFAM RNA-directed DNA polymerase (reverse transcriptase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002904 277.0
TH2_k127_466423_1 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005687 259.0
TH2_k127_466423_2 Cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000251 216.0
TH2_k127_4678588_0 Sulfatase K01130 - 3.1.6.1 1.82e-286 886.0
TH2_k127_4678588_1 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 461.0
TH2_k127_4678588_3 - - - - 0.000000000000000000000000000008252 120.0
TH2_k127_4678588_4 PFAM Carbohydrate-selective porin OprB K07267 - - 0.0000000000000005197 82.0
TH2_k127_4678588_5 Small-conductance mechanosensitive channel K05802 - - 0.0000002405 54.0
TH2_k127_4761633_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 8.269e-308 948.0
TH2_k127_4761633_1 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000341 240.0
TH2_k127_4761633_2 Putative restriction endonuclease - - - 0.00000000000000004007 83.0
TH2_k127_4776407_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 3.13e-256 793.0
TH2_k127_4776407_1 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 580.0
TH2_k127_4776407_10 Protein required for attachment to host cells - - - 0.000000000000000000000000000000000000438 144.0
TH2_k127_4776407_11 - - - - 0.00000000000000000000005189 114.0
TH2_k127_4776407_2 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 389.0
TH2_k127_4776407_3 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 334.0
TH2_k127_4776407_4 Belongs to the heat shock protein 70 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 309.0
TH2_k127_4776407_5 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000003854 241.0
TH2_k127_4776407_6 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000004624 237.0
TH2_k127_4776407_7 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000000008406 198.0
TH2_k127_4776407_8 Protein of unknown function (DUF3426) - - - 0.0000000000000000000000000000000000000000001609 166.0
TH2_k127_4776407_9 Putative peptidoglycan binding domain - - - 0.0000000000000000000000000000000000000004438 160.0
TH2_k127_4788447_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 7.069e-311 954.0
TH2_k127_4788447_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0000000000000000000000000001917 114.0
TH2_k127_4855002_0 PFAM Multicopper oxidase - - - 1.724e-224 713.0
TH2_k127_4855002_1 membrane - - - 0.0000000000000000000000000000000000000000000000000009515 192.0
TH2_k127_4855002_2 Belongs to the transketolase family - - - 0.0000000000000000000000000000000000000000000000004135 175.0
TH2_k127_4855002_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000006099 139.0
TH2_k127_4855002_4 - - - - 0.000000000000000000000000000000001283 138.0
TH2_k127_4855002_5 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000000001112 122.0
TH2_k127_4888642_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 0.0 1105.0
TH2_k127_4888642_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00819 - 2.6.1.13 4.799e-242 753.0
TH2_k127_4888642_10 TIGRFAM Hopanoid-associated phosphorylase K01243 - 3.2.2.9 0.0000000000000000000000000000000000000000000000000001511 194.0
TH2_k127_4888642_11 Copper resistance K07245 - - 0.0000000000000000000000000000000000000000000000009344 178.0
TH2_k127_4888642_12 CopC domain K07156 - - 0.0000000000000000000000000001433 120.0
TH2_k127_4888642_2 TIGRFAM Hopanoid biosynthesis associated radical SAM protein HpnH - - - 2.235e-204 640.0
TH2_k127_4888642_3 PFAM Squalene phytoene synthase K00801 - 2.5.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 569.0
TH2_k127_4888642_4 PFAM Aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 527.0
TH2_k127_4888642_5 MoeA N-terminal region (domain I K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 381.0
TH2_k127_4888642_6 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003725 347.0
TH2_k127_4888642_7 (Lipo)protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 322.0
TH2_k127_4888642_8 PFAM Toluene tolerance K07323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001421 270.0
TH2_k127_4888642_9 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000015 252.0
TH2_k127_4900594_0 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway K00351 - 1.6.5.8 2.732e-231 720.0
TH2_k127_4900594_1 Exonuclease C-terminal K01141 - 3.1.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 584.0
TH2_k127_4900594_2 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 437.0
TH2_k127_4900594_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00349 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 396.0
TH2_k127_4900594_4 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0055114 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 367.0
TH2_k127_4900594_5 TrkA-C domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 309.0
TH2_k127_4900594_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000004141 179.0
TH2_k127_4900594_7 (Na+)-NQR maturation NqrM K05952 - - 0.000000000000000181 81.0
TH2_k127_4907806_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1202.0
TH2_k127_4907806_1 Sulfatase - - - 5.599e-271 846.0
TH2_k127_4907806_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000001642 152.0
TH2_k127_4907806_11 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000003704 134.0
TH2_k127_4907806_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 4.102e-261 818.0
TH2_k127_4907806_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 7.947e-249 772.0
TH2_k127_4907806_4 Paraquat-inducible protein B - - - 3.268e-196 642.0
TH2_k127_4907806_5 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 602.0
TH2_k127_4907806_6 Belongs to the glycosyl hydrolase 57 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 567.0
TH2_k127_4907806_7 6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 294.0
TH2_k127_4907806_8 paraquat-inducible protein A K03808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000007491 219.0
TH2_k127_4907806_9 Paraquat-inducible protein A K03808 - - 0.000000000000000000000000000000000000000000000744 173.0
TH2_k127_4934766_0 Glycogen debranching enzyme - - - 0.0 1661.0
TH2_k127_4934766_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.545e-292 912.0
TH2_k127_4934766_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 5.502e-286 888.0
TH2_k127_4934766_3 Alpha amylase, catalytic domain - - - 1.026e-274 850.0
TH2_k127_4934766_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005582 434.0
TH2_k127_4934766_5 Phosphoglycerate mutase K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 340.0
TH2_k127_4934766_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 338.0
TH2_k127_4934766_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001951 278.0
TH2_k127_4940944_0 Fatty acid cis/trans isomerase (CTI) - - - 6.448e-287 902.0
TH2_k127_4940944_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000006197 245.0
TH2_k127_4977144_0 COG0575 CDP-diglyceride synthetase - - - 0.000000000000000000000000000000000000000001806 161.0
TH2_k127_4977144_1 Rhodanese Homology Domain - - - 0.000000000000000000000000000000002235 135.0
TH2_k127_4977144_2 - - - - 0.0000000000000000000000000000002005 127.0
TH2_k127_4977144_3 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000001855 71.0
TH2_k127_4988237_0 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006045 337.0
TH2_k127_4988237_1 Ceramidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001078 270.0
TH2_k127_4988237_2 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000007273 229.0
TH2_k127_4988237_3 Maf-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000007836 216.0
TH2_k127_4988237_4 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000009501 194.0
TH2_k127_4994315_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.117e-313 970.0
TH2_k127_4994315_1 chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 440.0
TH2_k127_4994315_2 Protein of unknown function (DUF2490) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007524 330.0
TH2_k127_4994315_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000002182 98.0
TH2_k127_4994315_5 Plasmid stability protein K21495 - - 0.000000000000000000001114 96.0
TH2_k127_4994315_6 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00003522 46.0
TH2_k127_5012728_0 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000999 375.0
TH2_k127_5012728_1 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001457 281.0
TH2_k127_5083578_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate - - - 4.6e-239 747.0
TH2_k127_5083578_1 TIGRFAM type I secretion outer membrane protein, TolC K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 490.0
TH2_k127_5083578_2 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001164 273.0
TH2_k127_5083578_3 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001966 250.0
TH2_k127_5083578_4 deoxycytidine triphosphate deaminase K09948 - - 0.00000000000000000000000000000000000006892 146.0
TH2_k127_5108570_0 Belongs to the glutaminase family K01425 - 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 502.0
TH2_k127_5108570_1 SMART Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000002923 190.0
TH2_k127_51203_0 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000007702 216.0
TH2_k127_51203_1 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000000000000000006209 208.0
TH2_k127_5129676_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.319e-255 801.0
TH2_k127_5129676_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 560.0
TH2_k127_5129676_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 396.0
TH2_k127_5129676_3 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000000000000000000001203 163.0
TH2_k127_5158409_0 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 517.0
TH2_k127_5158409_1 arsenate reductase K00537 - 1.20.4.1 0.00000000000000000000000000000000000000000000000238 175.0
TH2_k127_5158409_2 Belongs to the WrbA family K03809 - 1.6.5.2 0.0000000000000000000000000000000000000006704 151.0
TH2_k127_5165506_0 TIGRFAM PQQ-dependent catabolism-associated beta-propeller protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 482.0
TH2_k127_5165506_1 TIGRFAM ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 453.0
TH2_k127_5165506_2 TIGRFAM alcohol ABC transporter, permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 441.0
TH2_k127_5165506_3 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 375.0
TH2_k127_5165506_4 TIGRFAM ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004592 341.0
TH2_k127_5165506_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 299.0
TH2_k127_5165506_6 - - - - 0.0000000000000007538 78.0
TH2_k127_5165506_7 - - - - 0.00000000009253 65.0
TH2_k127_5228125_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1420.0
TH2_k127_5228125_1 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 434.0
TH2_k127_5248080_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 2.516e-242 752.0
TH2_k127_5248080_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.882e-222 692.0
TH2_k127_5248080_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 505.0
TH2_k127_5248080_3 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 294.0
TH2_k127_5320711_0 ABC transporter K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 563.0
TH2_k127_5320711_1 O-Antigen ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002369 287.0
TH2_k127_5320711_2 Glycosyl transferase family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000218 268.0
TH2_k127_5320711_3 - - - - 0.00000000000000000000005303 103.0
TH2_k127_5320711_4 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000003781 49.0
TH2_k127_5320711_5 Uncharacterised nucleotidyltransferase - - - 0.000003793 57.0
TH2_k127_5389210_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004934 530.0
TH2_k127_5389210_1 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 499.0
TH2_k127_5389210_2 Ferritin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004068 245.0
TH2_k127_5389210_3 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000003933 93.0
TH2_k127_5389210_4 Protein of unknown function, DUF393 - - - 0.0000000000000002177 80.0
TH2_k127_5406524_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 482.0
TH2_k127_5406524_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003241 286.0
TH2_k127_5406524_2 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000000000000000000000000000000000001102 235.0
TH2_k127_5406524_3 Ecotin K08276 - - 0.0000000000000000000000000000001552 129.0
TH2_k127_5406524_4 - - - - 0.0000000000000000000141 96.0
TH2_k127_5406524_5 mechanosensitive ion channel - - - 0.0000000000000000002698 89.0
TH2_k127_5448640_0 AIR synthase related protein, C-terminal K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 539.0
TH2_k127_5448640_1 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 460.0
TH2_k127_5448640_2 Belongs to the N-Me-Phe pilin family K02650 - - 0.0000000000000000000000000000000000000002563 156.0
TH2_k127_5448640_3 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000003382 145.0
TH2_k127_5469378_0 TIGRFAM Nitrate transport ATP-binding K15578 - - 0.0 999.0
TH2_k127_5469378_1 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15576 - - 7.854e-237 738.0
TH2_k127_5469378_2 PFAM Binding-protein-dependent transport systems inner membrane component K15577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 564.0
TH2_k127_5469378_3 Alginate export - - - 0.000000000000000000000000002412 116.0
TH2_k127_5469378_4 Peptidase C39 family K06992 - - 0.000000007297 66.0
TH2_k127_5469378_5 membrane protein of uknown function UCP014873 - - - 0.0000004506 60.0
TH2_k127_5475804_0 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 427.0
TH2_k127_5475804_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 389.0
TH2_k127_5475804_2 Ergosterol biosynthesis ERG4/ERG24 family K00222 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006694,GO:0008150,GO:0008152,GO:0008202,GO:0008610,GO:0009058,GO:0012505,GO:0016020,GO:0016021,GO:0016125,GO:0016126,GO:0016491,GO:0016627,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0036094,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:0098827,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.3.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 376.0
TH2_k127_5475804_3 MlaD protein K06192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 360.0
TH2_k127_5475804_4 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 353.0
TH2_k127_5475804_5 ABC-type transport auxiliary lipoprotein component K09857 - - 0.00000000000000000000000000000000000000000000000001279 186.0
TH2_k127_5475804_6 ERG2 and Sigma1 receptor like protein K20719 - - 0.00000000000000000000000000000000000008577 149.0
TH2_k127_5475804_7 - - - - 0.00000000000000000002468 94.0
TH2_k127_5494585_0 DNA RNA helicase - - - 0.0 1797.0
TH2_k127_5494585_1 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.0 1195.0
TH2_k127_5494585_2 Phosphate acyltransferases - - - 3.431e-273 860.0
TH2_k127_5494585_3 PFAM SWIM zinc finger - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 469.0
TH2_k127_5494585_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 475.0
TH2_k127_5494585_5 Helix-hairpin-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 459.0
TH2_k127_5494585_6 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 413.0
TH2_k127_5507977_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1263.0
TH2_k127_5507977_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 584.0
TH2_k127_5507977_2 Belongs to the Smg family K03747 - - 0.00000000000000000000000000000000000000000000000002905 181.0
TH2_k127_5513426_0 Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus K07261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 291.0
TH2_k127_5513426_1 PFAM Cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000175 200.0
TH2_k127_5513426_2 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000004198 195.0
TH2_k127_5513426_3 NUDIX domain - - - 0.00000000000000000000000000000000000000000005992 165.0
TH2_k127_5513426_4 Small metal-binding protein - - - 0.000000000000000000000000001262 116.0
TH2_k127_5513426_5 Putative peptidoglycan binding domain K21470 - - 0.000000000000000000009287 100.0
TH2_k127_5518318_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 7.473e-195 610.0
TH2_k127_5518318_1 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 458.0
TH2_k127_5518318_2 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 317.0
TH2_k127_5518318_3 Protein of unknown function (DUF1499) - - - 0.00000000000000000000000000000000000000000000002105 174.0
TH2_k127_5518318_4 NAD(P)H-binding - - - 0.00000000000000000000000000001438 120.0
TH2_k127_5531342_0 Oxaloacetate decarboxylase, alpha subunit K01571 - 4.1.1.3 1.88e-263 824.0
TH2_k127_5531342_1 Histidine kinase K07649 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 564.0
TH2_k127_5531342_2 response regulator - - - 0.00000000000000000000000000000000000000000000000001293 183.0
TH2_k127_5531342_3 Lyase and sodium transporter K01573 - 4.1.1.3 0.000001164 53.0
TH2_k127_5532426_0 Belongs to the peptidase S16 family - - - 0.0 1064.0
TH2_k127_5532426_1 ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 432.0
TH2_k127_5532426_2 - - - - 0.0000000000000001909 84.0
TH2_k127_5573518_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1101.0
TH2_k127_5573518_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.248e-223 699.0
TH2_k127_5573518_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 451.0
TH2_k127_5573518_3 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 347.0
TH2_k127_5573518_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 309.0
TH2_k127_5573518_5 SCP-2 sterol transfer family K03690 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001431 244.0
TH2_k127_5573518_6 Protein of unknown function (DUF971) - - - 0.000000000000000000000000000000000000000000000000000005706 192.0
TH2_k127_5573518_7 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.00000000000000000000000000000007185 124.0
TH2_k127_5573518_8 - - - - 0.00000000000000000000000000106 117.0
TH2_k127_5586541_0 TPM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 380.0
TH2_k127_5586541_1 LemA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 342.0
TH2_k127_5586541_2 membrane - - - 0.000000000000000000000000000000000000000000000000000002 200.0
TH2_k127_5586541_3 COGs COG1487 nucleic acid-binding protein contains PIN domain K18828 - - 0.00000000000000000000000000006374 120.0
TH2_k127_5586541_4 - - - - 0.000000000000411 72.0
TH2_k127_5586541_5 Transcriptional regulator K03655,K12573 - 3.6.4.12 0.0003759 47.0
TH2_k127_5588941_0 AAA domain - - - 0.0 1280.0
TH2_k127_5604614_0 Pfam Transposase IS66 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 449.0
TH2_k127_5604614_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001251 229.0
TH2_k127_5604614_2 FMN_bind - - - 0.000000000000000000000000000000000000000000000000000000000000003876 222.0
TH2_k127_5604614_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000000000552 173.0
TH2_k127_5604614_4 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000000000000000002305 132.0
TH2_k127_5617067_0 Belongs to the heat shock protein 70 family - - - 3.914e-315 975.0
TH2_k127_5617067_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 458.0
TH2_k127_5617067_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 417.0
TH2_k127_5617067_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 384.0
TH2_k127_5617067_4 Domain of unknown function (DUF2760) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001172 271.0
TH2_k127_5617067_5 - - - - 0.000000000000000000000000196 110.0
TH2_k127_5647624_0 GTP-binding protein TypA K06207 - - 0.0 1046.0
TH2_k127_5647624_1 Polysaccharide biosynthesis protein - - - 4.142e-267 834.0
TH2_k127_5647624_10 Glycerol-3-phosphate dehydrogenase K00111 - 1.1.5.3 0.000000000000000000005042 94.0
TH2_k127_5647624_11 Domain of Unknown Function with PDB structure (DUF3862) - - - 0.0000000000000000001776 91.0
TH2_k127_5647624_13 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.0008041 47.0
TH2_k127_5647624_2 HTH transcriptional regulator, LysR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 440.0
TH2_k127_5647624_3 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 416.0
TH2_k127_5647624_4 epimerase dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 307.0
TH2_k127_5647624_5 Glycosyl transferase family 4 K13007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001778 277.0
TH2_k127_5647624_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000004924 274.0
TH2_k127_5647624_7 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000003439 224.0
TH2_k127_5647624_8 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000002149 199.0
TH2_k127_5647624_9 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000000000000000000483 202.0
TH2_k127_5671948_0 Domain of unknown function (DUF1974) - - - 0.0 1073.0
TH2_k127_5671948_1 glutamate--cysteine ligase - - - 2.141e-216 680.0
TH2_k127_5671948_2 succinylglutamate desuccinylase activity K05526 - 3.5.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 438.0
TH2_k127_5673219_0 Nitrogen regulation K07712 - - 8.715e-222 696.0
TH2_k127_5673219_1 Signal transduction histidine kinase K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 478.0
TH2_k127_5673219_2 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 332.0
TH2_k127_5673219_3 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.000000000000000000000000000000000000000000000009319 177.0
TH2_k127_5673219_4 PFAM HTH transcriptional regulator, MarR - - - 0.0000000000000000000008254 95.0
TH2_k127_5673219_5 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000001672 83.0
TH2_k127_5676492_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 4.268e-225 704.0
TH2_k127_5676492_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 464.0
TH2_k127_5676492_2 PFAM Aminoacyl-tRNA synthetase, class II (G H P S), conserved region K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 430.0
TH2_k127_5676492_3 Tetratricopeptide repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001371 241.0
TH2_k127_5676492_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.000000000000000000000000000000000000000000000006231 175.0
TH2_k127_5682025_0 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 5.237e-213 668.0
TH2_k127_5682025_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 413.0
TH2_k127_5682025_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 402.0
TH2_k127_5682025_3 PFAM Sulphur oxidation protein SoxZ K17226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 334.0
TH2_k127_5682025_4 - - - - 0.000000000000000000000000000000000003299 156.0
TH2_k127_5682025_5 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 0.0005938 46.0
TH2_k127_5687098_0 PFAM Stage II sporulation protein E (SpoIIE) - - - 2.012e-253 796.0
TH2_k127_5687098_1 transcriptional regulator - - - 0.0000000000000004619 82.0
TH2_k127_5697311_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1541.0
TH2_k127_5697311_1 ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 480.0
TH2_k127_5697311_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 387.0
TH2_k127_5697311_3 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 380.0
TH2_k127_5701784_0 PFAM DNA mismatch repair protein MutS, C-terminal - - - 2.68e-225 709.0
TH2_k127_5701784_1 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009836 533.0
TH2_k127_5701784_2 Cytochrome c mono- and diheme variants - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003622 279.0
TH2_k127_5710692_0 Bacterial transglutaminase-like N-terminal - - - 0.0 1791.0
TH2_k127_5710692_1 Circularly permuted ATP-grasp type 2 - - - 0.0 1075.0
TH2_k127_5710692_10 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 305.0
TH2_k127_5710692_11 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003671 281.0
TH2_k127_5710692_12 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000001158 233.0
TH2_k127_5710692_2 Circularly permuted ATP-grasp type 2 - - - 6.214e-265 820.0
TH2_k127_5710692_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 599.0
TH2_k127_5710692_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 550.0
TH2_k127_5710692_5 PepSY-associated TM region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 511.0
TH2_k127_5710692_6 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 438.0
TH2_k127_5710692_7 PFAM 20S proteasome, A and B subunits K07395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 379.0
TH2_k127_5710692_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 312.0
TH2_k127_5710692_9 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 304.0
TH2_k127_5736697_0 Iron-containing redox enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 576.0
TH2_k127_5736697_1 Protein of unknown function (DUF3422) - - - 0.00000000000000000000000002694 110.0
TH2_k127_5736697_2 HYR domain - - - 0.0000000000000000000002082 98.0
TH2_k127_5745258_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 484.0
TH2_k127_5745258_1 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 470.0
TH2_k127_5745258_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 312.0
TH2_k127_5745258_3 Methyltransferase FkbM domain - - - 0.000004704 52.0
TH2_k127_5758833_0 Filamentation induced by cAMP protein fic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008556 516.0
TH2_k127_5758833_1 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002799 271.0
TH2_k127_5758833_2 Transposase - - - 0.000000000000000000000000000000000000000000000000000002572 195.0
TH2_k127_5758833_3 ISXO2-like transposase domain - - - 0.00000000000000000000000000000000000000000007206 160.0
TH2_k127_5790138_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 2.202e-273 854.0
TH2_k127_5790138_1 Belongs to the HSP15 family K04762 - - 0.0000000000000000000000000000000000000000000003593 169.0
TH2_k127_5790138_2 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000009225 162.0
TH2_k127_5790138_3 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000001059 139.0
TH2_k127_5796794_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 531.0
TH2_k127_5796794_1 Pfam Transposase IS66 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 308.0
TH2_k127_5796794_2 - - - - 0.000000000000000000000000000000000000002386 154.0
TH2_k127_5818826_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1137.0
TH2_k127_5818826_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000005224 177.0
TH2_k127_5838042_0 ABC transporter transmembrane region K06147,K18893 - - 2.474e-296 919.0
TH2_k127_5838042_1 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006698 318.0
TH2_k127_5838042_2 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 289.0
TH2_k127_5838042_3 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000000000000000004027 220.0
TH2_k127_5844949_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1103.0
TH2_k127_5844949_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 9.343e-260 807.0
TH2_k127_5855981_0 AcrB/AcrD/AcrF family K07787 - - 0.0 1544.0
TH2_k127_5855981_1 Cation efflux family K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 438.0
TH2_k127_5855981_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 402.0
TH2_k127_5855981_3 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 319.0
TH2_k127_5855981_4 Cation efflux family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 298.0
TH2_k127_5855981_5 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.00000000000000000000000000000000000000000001639 164.0
TH2_k127_5855981_6 - - - - 0.000000000000000000000000000000000000000003576 158.0
TH2_k127_5855981_7 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000005208 139.0
TH2_k127_587258_0 PFAM NnrS K07234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004911 481.0
TH2_k127_587258_1 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008884 452.0
TH2_k127_587258_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 371.0
TH2_k127_587258_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 301.0
TH2_k127_587258_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 296.0
TH2_k127_587258_5 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 290.0
TH2_k127_587258_6 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000003932 172.0
TH2_k127_587258_7 Domain of unknown function (DUF4845) - - - 0.000000000000000000000000000000001092 133.0
TH2_k127_5881347_0 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 321.0
TH2_k127_5881347_1 Glycine-zipper domain - - - 0.000000000000000000000000000000000000000000000002594 179.0
TH2_k127_5881347_2 AAA domain - - - 0.0000000000000000000000000000000000000002022 154.0
TH2_k127_5881347_3 - - - - 0.000000000000000000000000000000001008 140.0
TH2_k127_5882174_0 Squalene-hopene cyclase N-terminal domain K01852 - 5.4.99.7 2.234e-238 758.0
TH2_k127_5882174_1 Belongs to the BI1 family K19416 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 357.0
TH2_k127_5882174_2 Squalene epoxidase K00511 - 1.14.14.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007442 341.0
TH2_k127_5882174_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 299.0
TH2_k127_5882174_4 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 289.0
TH2_k127_5882174_5 Bacterial-like globin K06886 - - 0.00000000000000000000000000000000000000000000000000000004861 198.0
TH2_k127_5882174_6 MEKHLA domain - - - 0.00000000000000000000000000000000000000000008149 168.0
TH2_k127_5882174_7 - - - - 0.0000000000000000000000000004164 121.0
TH2_k127_5882174_8 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000005056 115.0
TH2_k127_5891032_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0 1001.0
TH2_k127_5891032_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 6.204e-197 619.0
TH2_k127_5891032_2 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 484.0
TH2_k127_5891032_3 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000000000000000000000000000000001209 236.0
TH2_k127_5891032_4 Hemerythrin HHE cation binding domain K07216 - - 0.00000000000000000000000000000000000002492 144.0
TH2_k127_5891032_5 Protein of unknown function (DUF2909) - - - 0.000000000000000002819 88.0
TH2_k127_589410_0 Aldehyde dehydrogenase family - - - 5.565e-216 678.0
TH2_k127_589410_1 Methionine synthase K00549,K22363 - 2.1.1.14,4.4.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 608.0
TH2_k127_589410_2 Glutathione S-transferase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004233 256.0
TH2_k127_589410_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.0000000000000000000000000000001079 126.0
TH2_k127_589410_4 - - - - 0.0000000000000000000213 92.0
TH2_k127_5922958_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 1.93e-246 766.0
TH2_k127_5922958_1 Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 599.0
TH2_k127_5922958_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0003881 44.0
TH2_k127_5940577_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 1283.0
TH2_k127_5940577_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 519.0
TH2_k127_5940577_2 - - - - 0.0000000000000000000000000003722 116.0
TH2_k127_5940577_3 - - - - 0.000000000000008051 76.0
TH2_k127_5940577_4 - - - - 0.0002488 47.0
TH2_k127_5964194_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1360.0
TH2_k127_5964194_1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000126 259.0
TH2_k127_5964194_2 Zinc-ribbon containing domain - - - 0.00000000000000000000000000000000000000000000003201 175.0
TH2_k127_5964194_3 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000006341 152.0
TH2_k127_5964194_4 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.00000000000000000000000000002165 124.0
TH2_k127_597439_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0 1017.0
TH2_k127_597439_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 8.397e-254 795.0
TH2_k127_597439_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 501.0
TH2_k127_597439_3 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000000000000000000003378 201.0
TH2_k127_597439_4 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000006532 114.0
TH2_k127_5987416_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 5.128e-237 736.0
TH2_k127_5987416_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 9.285e-236 734.0
TH2_k127_5987416_10 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 416.0
TH2_k127_5987416_11 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 400.0
TH2_k127_5987416_12 PFAM Dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 394.0
TH2_k127_5987416_13 3-oxoacyl-(Acyl-carrier-protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008415 394.0
TH2_k127_5987416_14 PFAM Aminotransferase, class IV K02619 - 4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 329.0
TH2_k127_5987416_15 DNA polymerase III, delta' K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 323.0
TH2_k127_5987416_16 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004874 277.0
TH2_k127_5987416_17 Belongs to the UPF0178 family K09768 - - 0.000000000000000000000000000000000000000000000000000000000000000005528 228.0
TH2_k127_5987416_18 PFAM Type IV pilus assembly PilZ K02676 - - 0.0000000000000000000000000000000000000000000000000000008006 196.0
TH2_k127_5987416_19 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000001387 198.0
TH2_k127_5987416_2 PFAM Binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 539.0
TH2_k127_5987416_20 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000000000000000000001074 170.0
TH2_k127_5987416_21 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000007517 134.0
TH2_k127_5987416_22 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000008493 133.0
TH2_k127_5987416_23 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.00000000000000000000009891 98.0
TH2_k127_5987416_24 - - - - 0.0000000000009776 70.0
TH2_k127_5987416_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 505.0
TH2_k127_5987416_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 497.0
TH2_k127_5987416_5 PFAM Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 492.0
TH2_k127_5987416_6 Multicopper oxidase K04753 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 490.0
TH2_k127_5987416_7 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 462.0
TH2_k127_5987416_8 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 462.0
TH2_k127_5987416_9 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 449.0
TH2_k127_5988649_0 COG0515 Serine threonine protein kinase K08884,K11912 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001261 270.0
TH2_k127_5988649_1 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000000000000000003113 237.0
TH2_k127_5988649_2 Maf-like protein K06287 - - 0.00000000001989 65.0
TH2_k127_5995971_0 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 2.989e-206 646.0
TH2_k127_5995971_1 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004879 253.0
TH2_k127_5995971_2 Phosphatidylinositol-specific phospholipase C, X domain K01771 - 4.6.1.13 0.0000000000003871 77.0
TH2_k127_6022702_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 311.0
TH2_k127_6022702_1 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 291.0
TH2_k127_6022702_2 Protein of unknown function (DUF4239) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007336 263.0
TH2_k127_6022702_3 TIGRFAM histidinol-phosphate phosphatase family protein K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000001809 187.0
TH2_k127_6022702_4 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000000000000000001204 171.0
TH2_k127_6022702_5 Transcriptional regulator K03655 - 3.6.4.12 0.0000000001062 64.0
TH2_k127_602366_0 PFAM Hydantoinase oxoprolinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 344.0
TH2_k127_602366_1 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006249 240.0
TH2_k127_602366_2 synthase component I K01665 - 2.6.1.85 0.00000000000000000000000000000000000000008747 154.0
TH2_k127_602366_3 PFAM SEC-C motif K09858 - - 0.000000000000000000000004404 105.0
TH2_k127_6047770_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 2.211e-255 793.0
TH2_k127_6047770_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000152 265.0
TH2_k127_6047770_2 Lipocalin-like domain K03098 - - 0.000000000000000000000000000000000000000000000000000000000001215 214.0
TH2_k127_6047770_3 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000002468 201.0
TH2_k127_6047770_4 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000003499 165.0
TH2_k127_6062055_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.483e-285 893.0
TH2_k127_6062055_1 PFAM Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000000000000000000000000000002424 189.0
TH2_k127_6062055_2 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000002657 179.0
TH2_k127_6062055_3 antiporter K07301 - - 0.000000000000000000000000000000000000003167 151.0
TH2_k127_6069761_0 TIGRFAM RNA polymerase sigma factor RpoS - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 461.0
TH2_k127_6069761_1 molybdopterin-guanine dinucleotide biosynthesis K03753 - - 0.00000000000000000000000000000000000000000000000000000000000000005784 227.0
TH2_k127_6069761_2 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000005995 124.0
TH2_k127_6069761_3 COG0303 Molybdopterin biosynthesis enzyme K03750 - 2.10.1.1 0.000000000003047 70.0
TH2_k127_6069761_4 Peptidase, M23 family K06194 - - 0.00000000004805 64.0
TH2_k127_6069761_5 Peptidase family M23 - - - 0.0000000003937 61.0
TH2_k127_6074230_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 5.359e-318 980.0
TH2_k127_6074230_1 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 574.0
TH2_k127_6074230_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004083 476.0
TH2_k127_6074230_3 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 452.0
TH2_k127_6074230_4 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003062 331.0
TH2_k127_6074230_5 (Lipo)protein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 319.0
TH2_k127_6074230_6 Bacterial SH3 domain homologues K07184 - - 0.0000000000000000000000000000000000000000000000000000000004383 211.0
TH2_k127_6074230_7 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000002741 172.0
TH2_k127_6074230_8 PFAM Uncharacterised protein family (UPF0150) - - - 0.0000000000003344 72.0
TH2_k127_6119783_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1256.0
TH2_k127_6119783_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 549.0
TH2_k127_6119783_2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 384.0
TH2_k127_6119783_3 Copper resistance protein B precursor (CopB) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 363.0
TH2_k127_6119783_4 Ribose 5-phosphate isomerase K01808 GO:0003674,GO:0003824,GO:0004751,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0008786,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0071704,GO:1901575 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000924 267.0
TH2_k127_6119783_5 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007181 267.0
TH2_k127_6119783_6 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000003637 247.0
TH2_k127_6119783_7 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 - - 0.000000000000000000000000000000000000000000000003311 181.0
TH2_k127_6119783_8 Rubredoxin - - - 0.000000000000000000000000000001032 121.0
TH2_k127_6125263_0 Type III restriction enzyme, res subunit - - - 1.947e-272 848.0
TH2_k127_6125263_1 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 1.498e-219 692.0
TH2_k127_6125263_2 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 404.0
TH2_k127_6125263_3 - - - - 0.0000000001112 64.0
TH2_k127_6126455_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 283.0
TH2_k127_6126455_1 protein homotetramerization - GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000000000000000000001289 163.0
TH2_k127_6126455_2 Transposase IS66 family - - - 0.000000000000000000000001602 108.0
TH2_k127_6126455_3 - - - - 0.00000000006247 66.0
TH2_k127_6126455_4 Transposase IS66 family K07484 - - 0.0000003988 56.0
TH2_k127_6126455_5 Involved in initiation control of chromosome replication K07484 - - 0.00004127 47.0
TH2_k127_6126455_6 Phage integrase family - - - 0.00004733 48.0
TH2_k127_613018_0 Sulfatase - - - 3.204e-221 695.0
TH2_k127_613018_1 Putative MetA-pathway of phenol degradation - - - 0.00000000000000000000000004898 111.0
TH2_k127_6139384_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1330.0
TH2_k127_6139384_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 4.519e-237 737.0
TH2_k127_6139384_2 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 471.0
TH2_k127_6139384_3 COG1651 Protein-disulfide isomerase K21990 - - 0.0000000000000000000000000000000000000000002601 168.0
TH2_k127_6139384_4 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000000002911 114.0
TH2_k127_6139384_5 Transposase IS66 family - - - 0.00000001854 57.0
TH2_k127_62425_0 PFAM 6-pyruvoyl tetrahydropterin K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000001055 220.0
TH2_k127_62425_1 UPF0056 inner membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000000000001488 221.0
TH2_k127_62425_2 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000000000000000245 193.0
TH2_k127_62425_3 Protein of unknown function (DUF1249) K09920 - - 0.0000000000000000000000000000000000000000001151 163.0
TH2_k127_62425_4 membrane - - - 0.000000000000000000000000000000003941 132.0
TH2_k127_62425_6 PilZ domain - - - 0.0000000000000002669 82.0
TH2_k127_62425_7 Bacterial extracellular solute-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.00000008257 58.0
TH2_k127_6242947_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 9.253e-265 819.0
TH2_k127_6242947_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 389.0
TH2_k127_6242947_2 AcrB/AcrD/AcrF family K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000232 254.0
TH2_k127_6242947_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000007899 189.0
TH2_k127_6242947_4 SBF-like CPA transporter family (DUF4137) K03453 - - 0.0000000009855 60.0
TH2_k127_6258233_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1311.0
TH2_k127_6258233_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.354e-251 782.0
TH2_k127_6258233_10 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 334.0
TH2_k127_6258233_11 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000569 265.0
TH2_k127_6258233_12 PFAM Cystathionine beta-synthase, core K04767 - - 0.000000000000000000000000000000000000000000000000000000000000000003114 229.0
TH2_k127_6258233_13 Belongs to the UPF0149 family K09895 - - 0.000000000000000000000000000000000000000000000001097 180.0
TH2_k127_6258233_14 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000000004098 109.0
TH2_k127_6258233_15 - K09892 - - 0.00000000000000001431 85.0
TH2_k127_6258233_16 - - - - 0.0000003779 53.0
TH2_k127_6258233_2 Belongs to the peptidase M24B family K01262 - 3.4.11.9 1.05e-229 716.0
TH2_k127_6258233_3 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 3.859e-229 714.0
TH2_k127_6258233_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008424 604.0
TH2_k127_6258233_5 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 507.0
TH2_k127_6258233_6 glucosidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 454.0
TH2_k127_6258233_7 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 379.0
TH2_k127_6258233_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 372.0
TH2_k127_6258233_9 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 357.0
TH2_k127_6267427_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.694e-260 809.0
TH2_k127_6267427_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 5.571e-234 734.0
TH2_k127_6267427_2 PFAM Formaldehyde-activating enzyme (Fae) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 321.0
TH2_k127_6267427_3 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000001212 208.0
TH2_k127_6267427_4 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000000000002243 195.0
TH2_k127_6267427_5 - - - - 0.00000000000000000000000000000003841 134.0
TH2_k127_6267427_6 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000000000001296 98.0
TH2_k127_6267427_7 - - - - 0.000000000000009422 78.0
TH2_k127_6275200_0 Large extracellular alpha-helical protein K06894 - - 1.454e-240 762.0
TH2_k127_6283395_0 ABC transporter K15738 - - 3.727e-220 700.0
TH2_k127_6283395_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 363.0
TH2_k127_6283395_2 lytic transglycosylase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004687 338.0
TH2_k127_6283395_3 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 334.0
TH2_k127_6283395_4 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000000000000000000000004522 222.0
TH2_k127_6283395_5 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000001202 112.0
TH2_k127_6283395_6 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000004399 76.0
TH2_k127_6283395_7 PFAM Metal-dependent phosphohydrolase, HD region, subdomain K08722 - 3.1.3.89 0.00006046 46.0
TH2_k127_6330183_0 DNA RNA helicase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005744 586.0
TH2_k127_6330183_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 378.0
TH2_k127_6330183_2 LppC putative lipoprotein K07121 - - 0.000000000000004513 81.0
TH2_k127_6341842_0 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 321.0
TH2_k127_6341842_1 TIGRFAM Mutator MutT protein K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 323.0
TH2_k127_6341842_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000005573 119.0
TH2_k127_6369698_0 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 479.0
TH2_k127_6369698_1 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 371.0
TH2_k127_6369698_2 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 342.0
TH2_k127_6369698_3 Lysin motif - - - 0.0000000000000000000000000000000000000000000004495 170.0
TH2_k127_6369698_4 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000000000000000000000000000008374 145.0
TH2_k127_6369698_5 Fe-S-cluster oxidoreductase K06940 - - 0.000000000000000000000000000000001285 131.0
TH2_k127_6369698_6 Lysin motif - - - 0.0000000000000000000000009992 105.0
TH2_k127_6369698_7 Belongs to the DsrF TusC family K07236 - - 0.000000000000000000005639 94.0
TH2_k127_6369698_8 - - - - 0.0000004941 56.0
TH2_k127_6377349_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 2.394e-320 985.0
TH2_k127_6377349_1 UvrD-like helicase C-terminal domain - - - 6.754e-280 870.0
TH2_k127_6377349_2 Superfamily II DNA RNA helicases, SNF2 family - - - 0.000154 50.0
TH2_k127_6382317_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 507.0
TH2_k127_6382317_1 PFAM Methylene-tetrahydromethanopterin dehydrogenase, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 426.0
TH2_k127_6382317_2 PFAM Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 424.0
TH2_k127_6382317_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000000000000001106 231.0
TH2_k127_6389668_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 4.034e-301 927.0
TH2_k127_6389668_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 8.169e-270 835.0
TH2_k127_6389668_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 603.0
TH2_k127_6389668_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 465.0
TH2_k127_6389668_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000000000000000000000001109 214.0
TH2_k127_6389668_5 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000006875 123.0
TH2_k127_6409833_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 507.0
TH2_k127_6409833_1 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000004061 203.0
TH2_k127_6409833_2 ABC transporter K02003 - - 0.00000000000000000000000000000533 122.0
TH2_k127_641894_0 PFAM Uncharacterised protein family (UPF0182) K09118 - - 0.0 1126.0
TH2_k127_641894_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 336.0
TH2_k127_641894_2 Cysteine-rich secretory protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005989 248.0
TH2_k127_641894_3 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000004995 175.0
TH2_k127_641894_5 lytic transglycosylase activity - - - 0.0000000006438 64.0
TH2_k127_641894_6 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000009129 55.0
TH2_k127_641894_7 SpoIIAA-like - - - 0.0000005753 52.0
TH2_k127_64267_0 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 514.0
TH2_k127_64267_1 Predicted membrane protein (DUF2231) - - - 0.0000000000000000000000000000000000000000000000000000000000008035 216.0
TH2_k127_64267_2 Protein conserved in bacteria - - - 0.000000000000003484 84.0
TH2_k127_6433015_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1562.0
TH2_k127_6433015_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004133 574.0
TH2_k127_6433015_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006515 361.0
TH2_k127_6433015_3 Protein of unknown function (DUF3240) - - - 0.000000000000000000000000000000000000003897 149.0
TH2_k127_6441472_0 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007855 452.0
TH2_k127_6441472_1 Transposase - - - 0.00000000000000000000000000000000000000000000000000000001077 198.0
TH2_k127_6441472_2 Protein of unknown function (DUF2845) - - - 0.00000000000000000000000000005827 119.0
TH2_k127_6472307_0 Alpha amylase, catalytic domain - - - 0.0 1227.0
TH2_k127_6472307_1 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 438.0
TH2_k127_6472307_2 PFAM TonB-dependent receptor, beta-barrel K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005192 306.0
TH2_k127_6472307_3 thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000000000000000000000000000000000002193 196.0
TH2_k127_6488171_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 2.275e-248 769.0
TH2_k127_6488171_1 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 424.0
TH2_k127_6488171_2 PFAM Polyketide cyclase dehydrase K16260 - - 0.000000000000000000000000000000000000000000000000000000000000000000003124 240.0
TH2_k127_6488171_3 - - - - 0.00000000000000000000000000000000000005706 143.0
TH2_k127_6488171_4 PIN domain - - - 0.0000000000000000000000000000003211 126.0
TH2_k127_6488171_5 protein conserved in bacteria K01790 GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704 5.1.3.13 0.000000000000000000000002387 105.0
TH2_k127_6488171_6 Protein of unknown function (DUF455) - - - 0.00000000000007144 72.0
TH2_k127_6509453_0 Major facilitator superfamily - - - 3.466e-213 670.0
TH2_k127_6509453_1 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03184 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 353.0
TH2_k127_6509453_2 - - - - 0.000000000000000000000000000005557 126.0
TH2_k127_6509453_3 TIGRFAM Lytic murein transglycosylase B K08305 - - 0.00000000000000000000000000305 111.0
TH2_k127_6530156_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - 5.239e-312 970.0
TH2_k127_6530156_1 Response regulator receiver - - - 2.629e-221 692.0
TH2_k127_6530156_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 523.0
TH2_k127_6530156_3 PFAM DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 454.0
TH2_k127_6530156_4 LysM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 427.0
TH2_k127_6530156_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006619 411.0
TH2_k127_6530156_6 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001241 269.0
TH2_k127_6530156_7 Transposase IS200 like K07491 - - 0.0000000000000000000000000000008052 123.0
TH2_k127_6530156_8 Transposase IS200 like K07491 - - 0.00000000000000000001342 93.0
TH2_k127_659446_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 522.0
TH2_k127_659446_1 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 379.0
TH2_k127_659446_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003375 282.0
TH2_k127_659446_3 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000207 245.0
TH2_k127_659446_4 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000000000000000001826 235.0
TH2_k127_659446_5 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000006909 126.0
TH2_k127_6623000_0 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K05685 - - 2.366e-241 755.0
TH2_k127_6623000_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007889 469.0
TH2_k127_6623000_2 MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 324.0
TH2_k127_6623000_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000000000000000000000000000000000000000000000000000000001035 224.0
TH2_k127_6623000_4 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000000000000000000007599 198.0
TH2_k127_6671296_0 HI0933-like protein K10210 - 1.14.99.44 1.152e-267 829.0
TH2_k127_6671296_1 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 574.0
TH2_k127_6671296_2 - - - - 0.0000000000000000000000000000000004973 132.0
TH2_k127_6701130_0 Belongs to the glycosyl hydrolase 30 family K01201 - 3.2.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 456.0
TH2_k127_6701130_1 Cellulose biosynthesis protein BcsQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 291.0
TH2_k127_6701130_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0000000000000000000001714 97.0
TH2_k127_6701130_3 6-phosphogluconolactonase K01057 - 3.1.1.31 0.000601 43.0
TH2_k127_6703358_0 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 543.0
TH2_k127_6703358_1 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009939 535.0
TH2_k127_6703358_2 Arabinose 5-phosphate isomerase K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 484.0
TH2_k127_6703358_3 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 415.0
TH2_k127_6703358_4 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 415.0
TH2_k127_6703358_5 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000006408 228.0
TH2_k127_6703358_6 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000007031 202.0
TH2_k127_6703358_7 STAS domain K07122 - - 0.000000000000000000000003974 106.0
TH2_k127_6703358_8 Cation transporter/ATPase, N-terminus - - - 0.00000000000332 70.0
TH2_k127_6703358_9 HNH nucleases - - - 0.00007105 46.0
TH2_k127_673061_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.552e-213 668.0
TH2_k127_673061_1 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 336.0
TH2_k127_673061_2 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 299.0
TH2_k127_673061_3 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004583 247.0
TH2_k127_673061_4 (ABC) transporter K02471,K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000009355 231.0
TH2_k127_673061_5 Glucose-6-phosphate dehydrogenase, NAD binding domain K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000004897 131.0
TH2_k127_673061_6 PFAM peptidase S8 and S53 subtilisin kexin sedolisin K08651 - 3.4.21.66 0.000000000000007215 88.0
TH2_k127_6790619_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 3.844e-268 841.0
TH2_k127_6790619_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 464.0
TH2_k127_6790619_2 Isocitrate K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 349.0
TH2_k127_6790619_3 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 336.0
TH2_k127_6790619_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 328.0
TH2_k127_6790619_5 zinc ion binding K06204 - - 0.00000000000000000000000000000001628 126.0
TH2_k127_6797933_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.509e-239 745.0
TH2_k127_6797933_1 Copper resistance K07245 - - 8.914e-201 634.0
TH2_k127_6820769_0 Acetyltransferase (GNAT) domain - - - 1.26e-308 952.0
TH2_k127_6820769_1 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 543.0
TH2_k127_6820769_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001222 268.0
TH2_k127_6820769_3 HpcH/HpaI aldolase/citrate lyase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007725 250.0
TH2_k127_6820769_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.000000000000000000000000002108 113.0
TH2_k127_6820769_5 ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - 0.000000000121 64.0
TH2_k127_6832045_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.002e-245 771.0
TH2_k127_6832045_1 ATP synthase alpha/beta family, beta-barrel domain K02118 - - 1.567e-238 742.0
TH2_k127_6832045_2 V-type ATPase 116kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 557.0
TH2_k127_6832045_3 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002039 255.0
TH2_k127_6832045_4 ATP synthase subunit D K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000001939 232.0
TH2_k127_6832045_5 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000001223 209.0
TH2_k127_6832045_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0000000000000000000000000000000000000000000000000000000002964 210.0
TH2_k127_6832045_7 Protein of unknown function (DUF2764) - - - 0.0000000000000000000000000000000000000000000001135 176.0
TH2_k127_6832045_8 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.000000000000000000000001573 111.0
TH2_k127_6836935_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity - - - 0.0 1373.0
TH2_k127_6836935_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 9.449e-220 690.0
TH2_k127_6836935_10 Alginate export - - - 0.0000000203 56.0
TH2_k127_6836935_11 - - - - 0.000000653 53.0
TH2_k127_6836935_12 Extracellular solute-binding protein K02048 - - 0.00008326 45.0
TH2_k127_6836935_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 604.0
TH2_k127_6836935_3 - - - - 0.000000000000000000000000000000000000000000002828 173.0
TH2_k127_6836935_4 - - - - 0.00000000000000000000000000000000000000000008568 166.0
TH2_k127_6836935_5 Alginate export - - - 0.00000000000000000000000000006474 116.0
TH2_k127_6836935_6 2 iron, 2 sulfur cluster binding - - - 0.000000000000000000000000001031 118.0
TH2_k127_6836935_7 Type II secretory pathway component ExeA - - - 0.00000000000000000005114 97.0
TH2_k127_6836935_8 Alginate export - - - 0.000000000000000001351 86.0
TH2_k127_6836935_9 - - - - 0.000000000000000005052 86.0
TH2_k127_6843129_0 TIGRFAM MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 614.0
TH2_k127_6843129_1 PFAM Nucleoside recognition - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 464.0
TH2_k127_6860029_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1674.0
TH2_k127_6860029_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1357.0
TH2_k127_6860029_10 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 354.0
TH2_k127_6860029_11 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 309.0
TH2_k127_6860029_12 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005573 265.0
TH2_k127_6860029_13 Thioredoxin-like [2Fe-2S] ferredoxin K00127 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003376 243.0
TH2_k127_6860029_14 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000005269 206.0
TH2_k127_6860029_15 alpha beta alpha domain I K01835 - 5.4.2.2 0.0000000000000000000000000000000000000001616 151.0
TH2_k127_6860029_16 - - - - 0.0000000000000000000000000000000000000866 146.0
TH2_k127_6860029_17 PFAM Lipid A Biosynthesis N-terminal - - - 0.0000000000000000000000000000000000001366 145.0
TH2_k127_6860029_18 Modulates RecA activity K03565 - - 0.000000000000000000000000000000000002271 143.0
TH2_k127_6860029_19 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.000000000000000000000000000008132 120.0
TH2_k127_6860029_2 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00124 - - 6.022e-275 852.0
TH2_k127_6860029_20 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.000000000000000000002043 95.0
TH2_k127_6860029_21 Belongs to the 'phage' integrase family - - - 0.00000000000002057 73.0
TH2_k127_6860029_22 PFAM Integrase core domain - - - 0.000000000003674 69.0
TH2_k127_6860029_23 - - - - 0.0000004408 51.0
TH2_k127_6860029_24 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0008703 43.0
TH2_k127_6860029_3 Belongs to the aspartokinase family K00928 - 2.7.2.4 1.444e-215 674.0
TH2_k127_6860029_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 587.0
TH2_k127_6860029_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 566.0
TH2_k127_6860029_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 465.0
TH2_k127_6860029_7 ZIP Zinc transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 385.0
TH2_k127_6860029_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 382.0
TH2_k127_6860029_9 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 361.0
TH2_k127_6936046_0 Belongs to the UPF0753 family K09822 - - 0.0 1225.0
TH2_k127_6936046_1 PFAM Sulfate transporter family - - - 1.159e-232 729.0
TH2_k127_6936046_2 Proton-conducting membrane transporter K00342 - 1.6.5.3 2.446e-201 638.0
TH2_k127_6936046_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004772 598.0
TH2_k127_6936046_4 overlaps another CDS with the same product name K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006 576.0
TH2_k127_6936927_0 PFAM Regulator of K conductance, N-terminal K10716 - - 1.507e-195 626.0
TH2_k127_6936927_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 494.0
TH2_k127_6936927_2 alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 374.0
TH2_k127_6936927_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 360.0
TH2_k127_6936927_4 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 296.0
TH2_k127_6936927_5 PFAM Regulator of K conductance, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001182 275.0
TH2_k127_6936927_6 Domain of unknown function (DUF4124) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007769 267.0
TH2_k127_6936927_7 YGGT family K02221 - - 0.00000000000000000000000000000000000000000000000000000000000000000001693 242.0
TH2_k127_6936927_8 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.000000000000000000000000000000000000000000000000000000000000000001728 231.0
TH2_k127_6936927_9 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor region K07675 - 2.7.13.3 0.000000000000000000000000000000000000001917 151.0
TH2_k127_693910_0 UvrD-like helicase C-terminal domain K03654 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 330.0
TH2_k127_693910_2 - - - - 0.00000000000000000000000006086 121.0
TH2_k127_693910_3 - - - - 0.000000000000000000004852 97.0
TH2_k127_693910_4 COG1943 Transposase and inactivated derivatives K07491 - - 0.00000000000002011 75.0
TH2_k127_6959891_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 9.575e-218 688.0
TH2_k127_6959891_1 ATP synthase K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000003085 241.0
TH2_k127_6959891_2 N-6 DNA Methylase K03427 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000002039 218.0
TH2_k127_6959891_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000002588 62.0
TH2_k127_69664_0 Vitamin B12 dependent methionine synthase, activation K00548 - 2.1.1.13 0.0 1975.0
TH2_k127_69664_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000004916 234.0
TH2_k127_69664_2 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000001462 207.0
TH2_k127_69664_3 - - - - 0.00000000000000000000004163 103.0
TH2_k127_69664_4 - - - - 0.0000000000000000058 89.0
TH2_k127_69664_6 Protein of unknown function (DUF2970) - - - 0.00000001415 57.0
TH2_k127_6977511_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 393.0
TH2_k127_6977511_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 316.0
TH2_k127_6977511_2 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000003557 92.0
TH2_k127_6977511_3 PFAM Smr - - - 0.000000002799 60.0
TH2_k127_7007376_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 0.0 1164.0
TH2_k127_7007376_1 RNA-binding protein - - - 0.0000000000000000000000000000000006004 132.0
TH2_k127_7028461_0 Mechanosensitive ion channel K16052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005994 371.0
TH2_k127_7028461_1 esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 289.0
TH2_k127_7028461_2 Domain of unknown function (DUF4410) - - - 0.0000000000000000000000000000000000000000000000000000000000000004701 226.0
TH2_k127_7028461_3 - - - - 0.000000000002038 68.0
TH2_k127_7032379_0 protein involved in exopolysaccharide biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 586.0
TH2_k127_7032379_1 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 455.0
TH2_k127_7032379_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 346.0
TH2_k127_7032379_3 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000000006228 136.0
TH2_k127_705098_0 pfkB family carbohydrate kinase K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 536.0
TH2_k127_705098_1 Histidine kinase K15011 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 433.0
TH2_k127_705098_2 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006406 393.0
TH2_k127_705098_3 response regulator K15012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 302.0
TH2_k127_705098_4 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.00000000000000000000000000000000000000000000000000001111 190.0
TH2_k127_705098_5 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000000001616 190.0
TH2_k127_7061636_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 3.246e-221 702.0
TH2_k127_7061636_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 3.691e-219 685.0
TH2_k127_7061636_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 564.0
TH2_k127_7061636_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 545.0
TH2_k127_7061636_4 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009124 527.0
TH2_k127_7061636_5 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 453.0
TH2_k127_7061636_6 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 447.0
TH2_k127_7061636_7 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 423.0
TH2_k127_7061636_8 Cell wall formation K00075 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 412.0
TH2_k127_7061636_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.000000000000000000000000000000000000000000000000000000008899 210.0
TH2_k127_7062522_0 Nitroreductase family - - - 5.759e-199 633.0
TH2_k127_7062522_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 540.0
TH2_k127_7062522_2 Protein of unknown function (DUF1488) - - - 0.000000000000000000000003755 104.0
TH2_k127_7062522_3 hmm pf01609 - - - 0.000000000000000000001888 97.0
TH2_k127_7062522_4 - - - - 0.00000002714 61.0
TH2_k127_7062522_5 hmm pf01609 - - - 0.0000009923 55.0
TH2_k127_7062522_6 Terminase small subunit K07474 - - 0.0006817 46.0
TH2_k127_7077600_0 FeS assembly SUF system protein SufT - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 312.0
TH2_k127_7077600_1 short-chain dehydrogenase reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 314.0
TH2_k127_7077600_2 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 299.0
TH2_k127_7077600_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00000000000000000000000000000000000000000002992 164.0
TH2_k127_7077600_4 - - - - 0.0000000000000000000000000000004389 123.0
TH2_k127_7091823_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 478.0
TH2_k127_7091823_1 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 430.0
TH2_k127_7091823_2 Etoposide-induced protein 2.4 (EI24) K06203 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008056 282.0
TH2_k127_7091823_3 Transposase IS200 like K07491 - - 0.000000000000000000000000003271 111.0
TH2_k127_7119669_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 0.0 1127.0
TH2_k127_7119669_1 50S ribosome-binding GTPase - - - 2.304e-224 698.0
TH2_k127_7119669_2 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD K03581 - 3.1.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005736 564.0
TH2_k127_7119669_3 NlpC/P60 family K13695,K19303 - - 0.0000000000000000000000000000000000000003151 154.0
TH2_k127_7119669_4 50S ribosome-binding GTPase K06946 - - 0.00000000000000000000000000000000000001494 145.0
TH2_k127_714704_0 ethanolamine kinase activity K07251 - 2.7.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 459.0
TH2_k127_714704_1 Uncharacterised protein family (UPF0227) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003852 247.0
TH2_k127_7163355_0 PFAM Glycosyl transferase family 2 - - - 2.523e-207 656.0
TH2_k127_7163355_1 ubiE/COQ5 methyltransferase family K15256 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 372.0
TH2_k127_7163355_2 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005304 274.0
TH2_k127_7169629_0 50S ribosome-binding GTPase - - - 1.347e-196 629.0
TH2_k127_7169629_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 385.0
TH2_k127_7169629_2 50S ribosome-binding GTPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 388.0
TH2_k127_7169629_3 Protein of unknown function (DUF2959) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006984 243.0
TH2_k127_7169629_4 - - - - 0.00000000000000000000000000000006505 131.0
TH2_k127_7169629_5 - - - - 0.0005003 45.0
TH2_k127_720576_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 3.331e-237 741.0
TH2_k127_720576_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 539.0
TH2_k127_720576_2 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 410.0
TH2_k127_7210_0 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004339 516.0
TH2_k127_7210_1 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000000000000000000000004151 173.0
TH2_k127_7210_2 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000002085 139.0
TH2_k127_7210_3 Transcriptional regulator - - - 0.0000000000005012 75.0
TH2_k127_7225100_0 PFAM FAD linked oxidase domain protein K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.3.15 8.299e-214 674.0
TH2_k127_7225100_1 PFAM Glycoside hydrolase, family 3, N-terminal K05349 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000000000000000000001825 233.0
TH2_k127_7225100_2 PFAM Uncharacterised protein family UPF0029, Impact, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000006614 229.0
TH2_k127_7225100_3 - - - - 0.00000000000000000000000000000000000307 141.0
TH2_k127_72352_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1474.0
TH2_k127_72352_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 336.0
TH2_k127_7261740_0 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 365.0
TH2_k127_7261740_1 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005983 267.0
TH2_k127_7261740_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000003397 257.0
TH2_k127_7261740_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000001905 155.0
TH2_k127_7261740_4 Sulfur oxidation protein SoxY K17226 - - 0.000000000000000000000000000000000774 136.0
TH2_k127_7261740_5 PFAM Sulphur oxidation protein SoxZ K17227 - - 0.000000000000000000000000000000002957 132.0
TH2_k127_7274367_0 Starch synthase catalytic domain K00703 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 7.316e-273 857.0
TH2_k127_7274367_1 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 1.241e-249 780.0
TH2_k127_7274367_2 Alpha amylase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 482.0
TH2_k127_7274367_3 Domain of unknown function (DUF4912) - - - 0.00006446 52.0
TH2_k127_7352535_0 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K17686 - 3.6.3.54 0.0 1055.0
TH2_k127_7352535_1 Mechanosensitive ion channel K05802 - - 1.447e-317 1007.0
TH2_k127_7352535_10 PFAM Methyltransferase - - - 0.0000000000000000000000000000004242 125.0
TH2_k127_7352535_11 Heavy-metal-associated domain K07213 - - 0.000000000000004844 76.0
TH2_k127_7352535_2 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 442.0
TH2_k127_7352535_3 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 342.0
TH2_k127_7352535_4 pfam abc K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 325.0
TH2_k127_7352535_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006355 303.0
TH2_k127_7352535_6 membrane transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 289.0
TH2_k127_7352535_7 High frequency lysogenization protein HflD homolog K07153 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 284.0
TH2_k127_7352535_8 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004047 266.0
TH2_k127_7352535_9 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 0.000000000000000000000000000000000000000000000000000000009244 203.0
TH2_k127_7377558_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 562.0
TH2_k127_7377558_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006255 275.0
TH2_k127_7377558_2 Lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000002122 224.0
TH2_k127_7377558_3 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000001875 143.0
TH2_k127_7380874_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 2.523e-232 733.0
TH2_k127_7380874_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 554.0
TH2_k127_7380874_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 516.0
TH2_k127_7380874_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000005366 256.0
TH2_k127_7380874_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000001668 217.0
TH2_k127_7380874_5 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.000000003413 61.0
TH2_k127_7431658_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 460.0
TH2_k127_7431658_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007832 377.0
TH2_k127_7431658_2 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 338.0
TH2_k127_7431658_3 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000002496 232.0
TH2_k127_7431658_4 PFAM Class II aldolase - - - 0.0000000000000000000000000000000000000000000000000000000009625 207.0
TH2_k127_7454518_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity K03583 - 3.1.11.5 0.0 1163.0
TH2_k127_7521513_0 Sulfate permease and related transporters (MFS superfamily) - - - 1.683e-224 708.0
TH2_k127_7521513_1 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 435.0
TH2_k127_7521513_2 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005455 261.0
TH2_k127_7521513_3 ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated - - - 0.000000000000000000000000000000000000000000000000000000000000000004465 229.0
TH2_k127_7538534_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K01507,K15987 - 3.6.1.1 0.0 1080.0
TH2_k127_7538534_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955 - 2.7.1.25,2.7.7.4 5.106e-231 726.0
TH2_k127_7538534_2 Transposase IS66 family K07484 - - 0.000001149 50.0
TH2_k127_758923_0 PFAM Cation H exchanger K03316 - - 5.097e-313 972.0
TH2_k127_758923_1 Transport of potassium into the cell K03549 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 522.0
TH2_k127_758923_2 Pfam:DUF490 K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002399 263.0
TH2_k127_75935_0 May be involved in recombinational repair of damaged DNA K03631 - - 5.092e-231 727.0
TH2_k127_75935_1 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 492.0
TH2_k127_75935_2 Belongs to the agmatine deiminase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005465 434.0
TH2_k127_75935_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 318.0
TH2_k127_75935_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000134 71.0
TH2_k127_75935_5 - - - - 0.0000004239 52.0
TH2_k127_759368_0 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 503.0
TH2_k127_759368_1 Group 1 truncated hemoglobin K06886 - - 0.000000000000000000000000000000000000000000000000000000009375 199.0
TH2_k127_759368_2 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000001442 177.0
TH2_k127_759368_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000582 159.0
TH2_k127_759368_4 Alginate export - - - 0.00000000000003502 72.0
TH2_k127_7609138_0 Argininosuccinate lyase C-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 494.0
TH2_k127_7609138_1 Coenzyme A transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 456.0
TH2_k127_7609138_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 451.0
TH2_k127_7609138_3 phosphosulfolactate synthase activity K08097 - 4.4.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 416.0
TH2_k127_7609138_4 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 402.0
TH2_k127_7609138_5 (2R)-phospho-3-sulfolactate synthase (ComA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 344.0
TH2_k127_7609138_6 Adenylosuccinate lyase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001443 271.0
TH2_k127_7609138_7 PFAM short chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005442 262.0
TH2_k127_7635828_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1337.0
TH2_k127_7635828_1 Cation transporter/ATPase, N-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 526.0
TH2_k127_7635828_2 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 295.0
TH2_k127_7635828_3 - - - - 0.00000000000000000000000000000000000216 141.0
TH2_k127_7635828_4 - - - - 0.00000000001467 69.0
TH2_k127_7702404_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 9.979e-205 644.0
TH2_k127_7702404_1 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 346.0
TH2_k127_7702404_2 (twin-arginine translocation) pathway signal - - - 0.000000000000000000000000000000000000000000000000000006871 195.0
TH2_k127_7702404_3 Glycine-zipper domain - - - 0.0000000000000000000007556 101.0
TH2_k127_7718338_0 C-terminal, D2-small domain, of ClpB protein K11907 - - 1.575e-295 915.0
TH2_k127_7718338_1 Type VI secretion, TssG K11895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 492.0
TH2_k127_772036_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1167.0
TH2_k127_772036_1 Belongs to the peptidase S1C family K04771,K04772 - 3.4.21.107 8.665e-201 635.0
TH2_k127_772036_2 3-beta hydroxysteroid dehydrogenase/isomerase family K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 574.0
TH2_k127_772036_3 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 287.0
TH2_k127_772036_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.00000000000000000000000000000000000000000000000000000000000002776 217.0
TH2_k127_772036_5 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000000000000000006698 161.0
TH2_k127_7733680_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 476.0
TH2_k127_7733680_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009669 317.0
TH2_k127_7733680_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000005233 178.0
TH2_k127_7733680_3 - - - - 0.00000000000000003376 81.0
TH2_k127_7816614_0 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 2.371e-302 930.0
TH2_k127_7816614_1 Glycosyl transferase family 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 408.0
TH2_k127_7816614_2 Cellulose biosynthesis protein BcsQ - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002913 265.0
TH2_k127_7816614_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000002922 225.0
TH2_k127_7816614_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000002292 72.0
TH2_k127_7840558_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00895,K21071 - 2.7.1.11,2.7.1.90 2.605e-249 771.0
TH2_k127_7840558_1 Thiamine biosynthesis protein (ThiI) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 559.0
TH2_k127_7840558_2 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000005524 227.0
TH2_k127_7840558_3 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000000000000000009554 127.0
TH2_k127_7840558_4 Protein of unknown function (DUF2818) - - - 0.0000000000000000000000001386 114.0
TH2_k127_7840558_5 Predicted membrane protein (DUF2231) - - - 0.00001866 48.0
TH2_k127_7851733_0 Non-specific lipid-transfer protein K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 462.0
TH2_k127_7851733_1 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000293 218.0
TH2_k127_7851733_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000002479 116.0
TH2_k127_7851733_3 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.000000000000000000000002387 105.0
TH2_k127_7851733_4 23S rRNA-intervening sequence protein - - - 0.0000000000000000000003346 100.0
TH2_k127_7851733_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000002812 64.0
TH2_k127_7877534_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 610.0
TH2_k127_7877534_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 572.0
TH2_k127_7877534_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 470.0
TH2_k127_7877534_3 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.0000000000000000000000000000000000000000000004125 168.0
TH2_k127_7877534_4 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.0000000000000000000000000000000000000009322 148.0
TH2_k127_7877534_5 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000000000000006629 124.0
TH2_k127_7877733_0 GMC oxidoreductase - - - 5.142e-264 821.0
TH2_k127_7877733_1 ABC transporter K02471 - - 3.745e-233 734.0
TH2_k127_7877733_2 Rhodanese Homology Domain K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001099 268.0
TH2_k127_7877733_3 helix_turn_helix, Lux Regulon - - - 0.0000000000001063 74.0
TH2_k127_7877733_4 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.0000001422 54.0
TH2_k127_7884492_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 577.0
TH2_k127_7884492_1 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 299.0
TH2_k127_7884492_2 - - - - 0.000000000000000000000000000000000000000000000000000001503 194.0
TH2_k127_7884492_3 Beta/Gamma crystallin - - - 0.0000000000000000000000000000000001664 138.0
TH2_k127_7884492_4 Penicillin-binding protein 5, C-terminal domain K07258 GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.0005003 45.0
TH2_k127_7888165_0 Zeta toxin - - - 9.33e-319 989.0
TH2_k127_7888165_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 3.017e-288 894.0
TH2_k127_7888165_2 PFAM PhoH-like protein K07175 - - 8.316e-243 756.0
TH2_k127_7888165_3 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000003231 213.0
TH2_k127_7888165_4 ACT domain K03567 - - 0.0000000000000000000000000000000000000000000000007298 179.0
TH2_k127_7888165_5 PFAM Excalibur calcium-binding domain - - - 0.0000000000000001869 85.0
TH2_k127_7904640_0 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 9.262e-200 631.0
TH2_k127_7904640_1 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 407.0
TH2_k127_7904640_2 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033036,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007155 292.0
TH2_k127_7904640_3 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000000000001603 228.0
TH2_k127_7904640_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.00000000000000000000000000000000003723 139.0
TH2_k127_7906921_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 3.044e-274 867.0
TH2_k127_7906921_1 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 2.446e-223 699.0
TH2_k127_7906921_2 virion core protein (lumpy skin disease virus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008285 463.0
TH2_k127_7906921_3 C-terminal domain of 1-Cys peroxiredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 396.0
TH2_k127_7906921_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 313.0
TH2_k127_7906921_5 Transcription factor zinc-finger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004888 246.0
TH2_k127_7906921_6 - - - - 0.000000000000000000000000000000000000000000001974 171.0
TH2_k127_7906921_7 Ferredoxin - - - 0.000000000000000000000000000000000000000000008018 165.0
TH2_k127_7906921_8 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000001123 146.0
TH2_k127_7914526_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 447.0
TH2_k127_7914526_1 CRISPR associated protein Cas1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 359.0
TH2_k127_7914526_2 CRISPR associated protein Cas1 - - - 0.000000000000000000000000000000000000000000000000009947 189.0
TH2_k127_7914526_3 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.00000000000000000000000000003992 120.0
TH2_k127_7914526_4 CRISPR associated protein Cas2 - - - 0.00000000000000000000000000351 114.0
TH2_k127_7921805_0 Aconitase C-terminal domain - - - 0.0 1461.0
TH2_k127_7921805_1 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01535 - 3.6.3.6 0.00000000000005641 71.0
TH2_k127_7921805_2 - - - - 0.0004742 44.0
TH2_k127_7926440_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1876.0
TH2_k127_7926440_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1e-323 1000.0
TH2_k127_7926440_2 Belongs to the CarA family K01956 - 6.3.5.5 7.128e-198 621.0
TH2_k127_7926440_3 Transglycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 606.0
TH2_k127_7926440_4 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 296.0
TH2_k127_7926440_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001263 254.0
TH2_k127_7926440_6 Aspartyl protease - - - 0.0000000000000000000000000002541 118.0
TH2_k127_7926440_7 CRS1_YhbY K07574 - - 0.0000000000000000000000000005233 115.0
TH2_k127_7937271_0 Transporter associated domain K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 325.0
TH2_k127_7937271_1 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000000000000000000000000000009535 249.0
TH2_k127_7937271_2 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000002735 203.0
TH2_k127_7937271_3 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm K09774 - - 0.00000000000000000000000000000000000000000000000000005575 192.0
TH2_k127_7937271_4 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000006648 171.0
TH2_k127_7937271_5 Branched-chain amino acid ATP-binding cassette transporter K06861 - - 0.0000000000000000000000000007605 113.0
TH2_k127_7937271_6 DDE superfamily endonuclease - - - 0.0000000000000000624 84.0
TH2_k127_7937271_7 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0000000242 65.0
TH2_k127_7944273_0 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 6e-323 1004.0
TH2_k127_7944273_1 Transcriptional activator of acetoin glycerol metabolism K21405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 586.0
TH2_k127_8011433_0 DDE_Tnp_1-associated - - - 0.00000000000000000000000000000000000000001991 159.0
TH2_k127_8011433_1 protein conserved in bacteria - - - 0.00000000000000000000000000000002902 127.0
TH2_k127_8011433_2 transposase activity - - - 0.000000000000000000000000000004747 128.0
TH2_k127_8011433_3 Putative DNA-binding domain K09929 - - 0.0000007176 53.0
TH2_k127_8030255_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1297.0
TH2_k127_8030255_1 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009998 436.0
TH2_k127_8030255_2 AI-2E family transporter - - - 0.000000000000000000000002205 106.0
TH2_k127_8063923_0 Catalyzes the synthesis of activated sulfate K00860,K00958 - 2.7.1.25,2.7.7.4 3.634e-263 825.0
TH2_k127_8063923_1 Mg chelatase-related protein K07391 - - 6.978e-253 787.0
TH2_k127_8063923_10 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 366.0
TH2_k127_8063923_11 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 317.0
TH2_k127_8063923_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005095 304.0
TH2_k127_8063923_13 Protein of unknown function (DUF1097) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001847 251.0
TH2_k127_8063923_14 PFAM Uncharacterised protein family UPF0079, ATPase bacteria K06925 - - 0.00000000000000000000000000000000000000000000000003489 182.0
TH2_k127_8063923_15 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000004526 151.0
TH2_k127_8063923_16 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000000000000000000000000000000002327 150.0
TH2_k127_8063923_17 Membrane fusogenic activity K09806 - - 0.0000000000000000000000000003386 116.0
TH2_k127_8063923_18 - - - - 0.000000000000000000000001781 109.0
TH2_k127_8063923_19 - - - - 0.0000000000001134 74.0
TH2_k127_8063923_2 TIGRFAM Pilus retraction protein PilT K02669 - - 1.275e-198 622.0
TH2_k127_8063923_20 Domain of unknown function (DUF4389) - - - 0.000002799 53.0
TH2_k127_8063923_3 TIGRFAM Pilus retraction protein PilT K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 597.0
TH2_k127_8063923_4 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 592.0
TH2_k127_8063923_5 A G-specific adenine glycosylase K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 438.0
TH2_k127_8063923_6 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 413.0
TH2_k127_8063923_7 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 398.0
TH2_k127_8063923_8 Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 393.0
TH2_k127_8063923_9 Glutamyl glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain K01886 - 6.1.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 367.0
TH2_k127_810210_0 Cytochrome c-type biogenesis protein K02198 - - 2.631e-262 824.0
TH2_k127_810210_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 368.0
TH2_k127_810210_10 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.00000001217 62.0
TH2_k127_810210_11 Cytochrome c-type biogenesis protein K02200 - - 0.0005464 46.0
TH2_k127_810210_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004338 282.0
TH2_k127_810210_3 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000141 267.0
TH2_k127_810210_4 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004123 269.0
TH2_k127_810210_5 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000006779 248.0
TH2_k127_810210_6 Thiol disulfide interchange protein K02199 - - 0.00000000000000000000000000000000000000000000000000000003199 202.0
TH2_k127_810210_7 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000000002128 183.0
TH2_k127_810210_8 subunit of a heme lyase K02200 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - 0.0000000000000000000000000000000000000002131 160.0
TH2_k127_810210_9 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.000000000000003755 78.0
TH2_k127_8103072_0 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00347 - 1.6.5.8 8.224e-225 700.0
TH2_k127_8103072_1 Glutamyl glutaminyl-tRNA synthetase, class Ic, anti-codon binding domain K01886 - 6.1.1.18 2.905e-213 666.0
TH2_k127_8103072_2 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 464.0
TH2_k127_8103072_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000002765 218.0
TH2_k127_8104671_0 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 575.0
TH2_k127_8104671_1 Belongs to the CinA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 451.0
TH2_k127_8104671_2 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 389.0
TH2_k127_8104671_3 FtsJ-like methyltransferase K06968 - 2.1.1.186 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 361.0
TH2_k127_8104671_4 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 351.0
TH2_k127_8104671_5 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 338.0
TH2_k127_8104671_6 FHA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003299 228.0
TH2_k127_8104671_7 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000004175 170.0
TH2_k127_8143638_0 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 396.0
TH2_k127_8143638_1 Belongs to the Fur family K09823 - - 0.00000000000000000000000000000000000000000000000000000000000000003236 227.0
TH2_k127_8143638_2 Domain of unknown function DUF29 - - - 0.00000000000000000000000000000000000000000000000000000003106 199.0
TH2_k127_8143638_3 ApaG domain K06195 - - 0.00000000000000000000000000000000000000000000000000002349 192.0
TH2_k127_8143638_4 Domain of unknown function (DUF4124) - - - 0.00000000000000000000000000000000000000000000000003026 185.0
TH2_k127_8143638_5 - - - - 0.00000000000000000000000000000000000000000002017 163.0
TH2_k127_8143638_6 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000001296 98.0
TH2_k127_8143638_7 amine dehydrogenase activity K20276 - - 0.00005664 47.0
TH2_k127_8146073_0 Beta-Casp domain K07576 - - 6.038e-215 675.0
TH2_k127_8146073_1 Belongs to the 5'-nucleotidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 425.0
TH2_k127_8146073_2 Inositol monophosphatase family K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009763 334.0
TH2_k127_8146073_3 - catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.000000000807 66.0
TH2_k127_8163613_0 TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN K07003 - - 7.924e-251 792.0
TH2_k127_8163613_1 Cytochrome P450 K05917 - 1.14.13.70 5.326e-212 672.0
TH2_k127_8163613_2 - - - - 0.000000000000000000000000000000000000000000008377 176.0
TH2_k127_8163613_3 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000002249 122.0
TH2_k127_8178332_0 ABC1 family K03688 - - 2.17e-277 861.0
TH2_k127_8178332_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005822 610.0
TH2_k127_8178332_2 Isochorismatase family K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000007766 241.0
TH2_k127_8178332_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000003722 187.0
TH2_k127_8178332_4 - - - - 0.0000000000000000000000000000002447 126.0
TH2_k127_8178332_5 heat shock protein DnaJ - - - 0.00000002226 58.0
TH2_k127_8190008_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1474.0
TH2_k127_8190008_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.969e-285 884.0
TH2_k127_8190008_2 PIN domain K07065 - - 0.0000000000000000000000000000000000000000001214 162.0
TH2_k127_8190008_3 - - - - 0.000001665 54.0
TH2_k127_8192613_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.4.2 0.0 1494.0
TH2_k127_8192613_1 UPF0313 protein - - - 0.0 1154.0
TH2_k127_8192613_2 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 511.0
TH2_k127_8192613_3 Glycine cleavage system T protein K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 410.0
TH2_k127_8192613_4 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009023 369.0
TH2_k127_8192613_5 Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions K09913 GO:0003674,GO:0003824,GO:0004731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016154,GO:0016740,GO:0016757,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.1,2.4.2.2 0.000000000000000000000000000000000002363 139.0
TH2_k127_8199662_0 ABC transporter transmembrane region K06148 - - 2.778e-278 866.0
TH2_k127_8199662_1 Soluble lytic murein transglycosylase L domain K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006669 583.0
TH2_k127_8199662_2 PHP domain K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 371.0
TH2_k127_8199662_3 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000001426 213.0
TH2_k127_819986_0 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 3.042e-219 683.0
TH2_k127_819986_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 9.081e-214 669.0
TH2_k127_819986_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 439.0
TH2_k127_8208844_0 4Fe-4S dicluster domain K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 488.0
TH2_k127_8208844_1 COG0277 FAD FMN-containing dehydrogenases K11472 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 391.0
TH2_k127_8208844_2 Peptidoglycan-binding protein, CsiV - - - 0.000000002118 61.0
TH2_k127_8214668_0 Transglycosylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 511.0
TH2_k127_8214668_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002229 252.0
TH2_k127_8214668_2 - - - - 0.000000000000000000000000000000001319 135.0
TH2_k127_82166_0 MreB/Mbl protein - - - 2.353e-273 850.0
TH2_k127_82166_1 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 442.0
TH2_k127_82166_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 366.0
TH2_k127_82166_3 GrpE K03687 - - 0.000000000000000000000000000000000000000000000000000000000436 209.0
TH2_k127_82166_4 AI-2E family transporter - - - 0.0000000000000000000000000000000000000003646 151.0
TH2_k127_82166_5 DnaJ molecular chaperone homology domain - - - 0.0000000000000000000000005166 108.0
TH2_k127_82166_7 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000001438 50.0
TH2_k127_8221075_0 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 592.0
TH2_k127_8221075_1 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008689 415.0
TH2_k127_8221075_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 382.0
TH2_k127_8221075_3 response to pH - - - 0.00000000000000000000000000000000000000000000000000000003785 202.0
TH2_k127_8232577_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.199e-215 673.0
TH2_k127_8232577_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 332.0
TH2_k127_8232577_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000009215 165.0
TH2_k127_8243382_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008368 602.0
TH2_k127_8243382_1 PFAM IstB-like ATP binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006219 370.0
TH2_k127_8243382_2 Belongs to the 'phage' integrase family - - - 0.000001761 53.0
TH2_k127_8243382_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.00003569 48.0
TH2_k127_8246995_0 Transport of potassium into the cell K03549 - - 8.408e-309 953.0
TH2_k127_8246995_1 Histidine kinase K07646 - 2.7.13.3 3.3e-207 665.0
TH2_k127_8246995_2 Histidine kinase K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 382.0
TH2_k127_8246995_3 - - - - 0.00000000000002041 79.0
TH2_k127_8247507_0 FAD binding domain K09828 - 1.3.1.72 3.07e-231 727.0
TH2_k127_8247507_1 COG0480 Translation elongation factors (GTPases) K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 541.0
TH2_k127_8281649_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 477.0
TH2_k127_8281649_1 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002863 272.0
TH2_k127_8281649_2 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000001485 273.0
TH2_k127_8281649_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005115 261.0
TH2_k127_8281649_4 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000001774 135.0
TH2_k127_8281649_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000003128 55.0
TH2_k127_8281649_6 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.0000007958 63.0
TH2_k127_8327582_0 Pentapeptide repeats (9 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 437.0
TH2_k127_8327582_1 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 435.0
TH2_k127_8373336_0 PFAM Bacterial extracellular solute-binding - - - 9.031e-310 965.0
TH2_k127_8373336_1 DHH family K07462 - - 1.848e-267 833.0
TH2_k127_8373336_10 Formiminotransferase-cyclodeaminase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002953 274.0
TH2_k127_8373336_11 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000000000000000000009258 241.0
TH2_k127_8373336_12 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000001088 145.0
TH2_k127_8373336_13 Domain of unknown function (DUF4160) - - - 0.000000000000000000000000000000000008385 136.0
TH2_k127_8373336_14 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000001959 136.0
TH2_k127_8373336_15 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000000000000175 128.0
TH2_k127_8373336_16 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000004041 105.0
TH2_k127_8373336_17 Domain of unknown function (DUF4136) - - - 0.000000000000000000000006463 110.0
TH2_k127_8373336_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 6.21e-241 752.0
TH2_k127_8373336_3 PFAM Aminotransferase, class I K14261 - - 8.305e-231 717.0
TH2_k127_8373336_4 homoserine dehydrogenase K00003 - 1.1.1.3 5.82e-229 715.0
TH2_k127_8373336_5 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 1.038e-208 655.0
TH2_k127_8373336_6 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 581.0
TH2_k127_8373336_7 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 432.0
TH2_k127_8373336_8 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004547 314.0
TH2_k127_8373336_9 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 283.0
TH2_k127_8385138_0 Belongs to the peptidase M16 family K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 610.0
TH2_k127_8385138_1 PFAM Peptidase M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005887 552.0
TH2_k127_8385138_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009835 451.0
TH2_k127_8385138_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008809 396.0
TH2_k127_8385138_4 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 359.0
TH2_k127_8385138_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008666 295.0
TH2_k127_8385138_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000000000000000000000001051 228.0
TH2_k127_8385138_7 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 0.00000000000000000000000000000000000000000000000000000009328 201.0
TH2_k127_8385138_8 Protein of unknown function (DUF2934) - - - 0.000000000006074 68.0
TH2_k127_8385138_9 COG1484 DNA replication protein - - - 0.00000004169 56.0
TH2_k127_8428662_0 Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) K00672 - 2.3.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008995 541.0
TH2_k127_8428662_1 TIGRFAM formylmethanofuran dehydrogenase subunit C K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 368.0
TH2_k127_8428662_2 TIGRFAM Formylmethanofuran dehydrogenase, subunit A K00200 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000015 252.0
TH2_k127_8428662_3 Protein of unknown function (DUF2442) - - - 0.000000000000000000000000000000000000000001825 157.0
TH2_k127_8428662_5 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000000000000000000002267 111.0
TH2_k127_8428662_6 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000007657 102.0
TH2_k127_8439982_0 PFAM 5'-nucleotidase K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 450.0
TH2_k127_8439982_1 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 311.0
TH2_k127_8439982_2 PFAM Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002866 246.0
TH2_k127_8439982_3 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000001757 185.0
TH2_k127_8439982_4 - - - - 0.0000000000000000000000000000004656 128.0
TH2_k127_8439982_5 Antibiotic biosynthesis monooxygenase - - - 0.0000000000003606 74.0
TH2_k127_8443123_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 3.792e-247 767.0
TH2_k127_8443123_1 PFAM Multicopper oxidase, type K04753,K08100,K14588 - 1.3.3.5 3.102e-218 691.0
TH2_k127_8443123_11 Stress responsive A/B Barrel Domain - - - 0.0000000000000000000000000000000000000004907 153.0
TH2_k127_8443123_12 - - - - 0.000000000001483 71.0
TH2_k127_8443123_13 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000505 61.0
TH2_k127_8443123_2 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042802,GO:0042803,GO:0044237,GO:0044249,GO:0044271,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 528.0
TH2_k127_8443123_3 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 469.0
TH2_k127_8443123_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 458.0
TH2_k127_8443123_5 Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 463.0
TH2_k127_8443123_6 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 408.0
TH2_k127_8443123_7 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 384.0
TH2_k127_8443123_8 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000077 232.0
TH2_k127_8443123_9 NfeD-like C-terminal, partner-binding K07340 - - 0.00000000000000000000000000000000000000000000000000000004885 199.0
TH2_k127_8444777_0 SCO1/SenC - - - 2.66e-253 790.0
TH2_k127_8444777_1 TrkA-C domain K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 476.0
TH2_k127_8445726_0 Lipase maturation factor - - - 1.309e-202 642.0
TH2_k127_8445726_1 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000007371 221.0
TH2_k127_8445726_2 - - - - 0.000000000000000000000000000000000000001893 150.0
TH2_k127_8445726_3 Glycine-zipper domain - - - 0.000000000000000000007812 94.0
TH2_k127_8445726_4 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000707 86.0
TH2_k127_8445726_5 Protein of unknown function (DUF1254) - - - 0.00008226 45.0
TH2_k127_8487058_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 544.0
TH2_k127_8487058_1 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 363.0
TH2_k127_8487058_2 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000004754 213.0
TH2_k127_8487058_3 alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000002078 190.0
TH2_k127_8536201_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 9.857e-232 734.0
TH2_k127_8536201_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008905 409.0
TH2_k127_8536201_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 385.0
TH2_k127_8536201_3 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 327.0
TH2_k127_8536201_4 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000006165 183.0
TH2_k127_8566863_0 Enoyl-CoA hydratase/isomerase - - - 3.744e-230 718.0
TH2_k127_8566863_1 Transglycosylase SLT domain K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 500.0
TH2_k127_8566863_2 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 407.0
TH2_k127_8566863_3 - - - - 0.00000000000007345 72.0
TH2_k127_8601276_0 TIGRFAM SUF system FeS cluster assembly, SufD K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 548.0
TH2_k127_8601276_1 ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009064 428.0
TH2_k127_8601276_2 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001271 262.0
TH2_k127_8601276_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000002344 245.0
TH2_k127_8615986_0 argininosuccinate lyase K01755 - 4.3.2.1 8.555e-225 706.0
TH2_k127_8615986_1 TIGRFAM dihydroorotase, multifunctional complex type K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 584.0
TH2_k127_8615986_10 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007113 261.0
TH2_k127_8615986_11 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000002224 230.0
TH2_k127_8615986_12 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000000000000000000009881 218.0
TH2_k127_8615986_13 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ - - - 0.0000000000000000000000000000000000000000004907 160.0
TH2_k127_8615986_14 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000002987 106.0
TH2_k127_8615986_15 Selenoprotein, putative - - - 0.00000000000002414 75.0
TH2_k127_8615986_16 ABC transporter substrate-binding protein - - - 0.00009787 45.0
TH2_k127_8615986_2 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007891 518.0
TH2_k127_8615986_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 520.0
TH2_k127_8615986_4 HemY protein N-terminus K02498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 521.0
TH2_k127_8615986_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 445.0
TH2_k127_8615986_6 HemX, putative uroporphyrinogen-III C-methyltransferase K02496,K13543 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 425.0
TH2_k127_8615986_7 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 377.0
TH2_k127_8615986_8 TonB C terminal K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 315.0
TH2_k127_8615986_9 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000947 272.0
TH2_k127_8632606_0 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 360.0
TH2_k127_8632606_1 pfam ammecr1 K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000001836 226.0
TH2_k127_8632606_2 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000005437 156.0
TH2_k127_8632606_3 - - - - 0.000000000000006922 82.0
TH2_k127_8632606_4 - - - - 0.000000000002494 72.0
TH2_k127_8639343_0 Belongs to the GPI family K01810 - 5.3.1.9 4.074e-267 833.0
TH2_k127_8639343_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 411.0
TH2_k127_8639343_2 PFAM multicopper oxidase type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 360.0
TH2_k127_8639343_3 - - - - 0.000000000000000000000000000000000000000000000000000000000001959 214.0
TH2_k127_8639343_4 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000006602 186.0
TH2_k127_8639343_5 Membrane - - - 0.00000000000000000000000000000000000000000000001469 174.0
TH2_k127_8649216_0 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 4.671e-272 843.0
TH2_k127_8649216_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 494.0
TH2_k127_8649216_2 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 284.0
TH2_k127_8649216_3 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003743 267.0
TH2_k127_8649216_4 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000000000000000000977 210.0
TH2_k127_866062_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 9.51e-196 614.0
TH2_k127_866062_1 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 426.0
TH2_k127_866062_2 TIGRFAM Serine O-acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006238 421.0
TH2_k127_866062_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 319.0
TH2_k127_866062_4 Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 296.0
TH2_k127_866062_5 Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins K13643 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008689 248.0
TH2_k127_866062_6 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000000000000000005738 244.0
TH2_k127_866062_7 Cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000848 241.0
TH2_k127_868621_0 Glycosyl hydrolase family 57 - - - 2.525e-237 742.0
TH2_k127_868621_1 Protein of unknown function (DUF2490) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 353.0
TH2_k127_8721561_0 Phage integrase, N-terminal SAM-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 485.0
TH2_k127_8721561_1 Integrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 434.0
TH2_k127_8721561_2 Integrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 414.0
TH2_k127_8721561_3 PFAM Transposase, IS66 K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000002861 237.0
TH2_k127_8721561_4 PFAM Transposase IS66 family K07484 - - 0.00000000000000000000000000002305 117.0
TH2_k127_8774752_0 TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family - - - 0.0 1148.0
TH2_k127_8774752_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000259 524.0
TH2_k127_8774752_2 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006186 239.0
TH2_k127_8774752_3 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000001338 237.0
TH2_k127_8774752_4 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000000000000000000000001895 153.0
TH2_k127_8774752_5 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000000000001835 102.0
TH2_k127_880476_0 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006984 555.0
TH2_k127_880476_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 531.0
TH2_k127_880476_2 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters K02170 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002976 281.0
TH2_k127_880476_3 Competence protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004933 274.0
TH2_k127_880476_4 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 0.000000000000000000000000000000000001633 142.0
TH2_k127_880476_5 Hemerythrin HHE cation binding domain K07216 - - 0.00000000000000000000000000000000006158 135.0
TH2_k127_880476_6 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000001653 114.0
TH2_k127_880476_7 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 GO:0003674,GO:0003824,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197 0.0000000000000000000000006107 108.0
TH2_k127_880476_8 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.00000000000000000001835 95.0
TH2_k127_8806756_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.298e-311 962.0
TH2_k127_8806756_1 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 513.0
TH2_k127_8806756_2 Regulatory protein, FmdB family - - - 0.0000000000000000000000000000000000000001236 151.0
TH2_k127_8806756_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000006122 93.0
TH2_k127_8813993_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1958.0
TH2_k127_8813993_1 Glutamate synthase, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000002631 169.0
TH2_k127_8813993_2 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.00000000001141 65.0
TH2_k127_8835212_0 DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 467.0
TH2_k127_8835212_1 PFAM FxsA cytoplasmic membrane protein K07113 - - 0.000000000000000000000000000000000000000000000000003323 186.0
TH2_k127_8835212_2 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000001212 107.0
TH2_k127_8853013_0 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 522.0
TH2_k127_8853013_1 Belongs to the ParA family K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 480.0
TH2_k127_8853013_2 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization K03610 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004872 248.0
TH2_k127_8853013_3 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell K03608 - - 0.0000000000000000000000000000000007045 135.0
TH2_k127_8853013_4 Winged helix-turn-helix domain (DUF2582) - - - 0.00000000000000000001932 92.0
TH2_k127_8882378_0 Protein of unknown function (DUF3375) - - - 2.761e-250 778.0
TH2_k127_8882378_1 Domain of unknown function (DUF4194) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 285.0
TH2_k127_8882378_2 protein homotetramerization - - - 0.00003922 47.0
TH2_k127_8886464_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0 1146.0
TH2_k127_8886464_1 B12 binding domain - - - 4.027e-300 924.0
TH2_k127_8886464_2 PIN domain - - - 0.000000000000000000000000000000000000000000000000000000000000009293 218.0
TH2_k127_8886464_3 Haem-degrading - - - 0.00000000000000000000000000000000000000000000002105 174.0
TH2_k127_8886464_4 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000000000000000008316 151.0
TH2_k127_8886464_5 Fatty acid cis/trans isomerase (CTI) - - - 0.000000000000004675 75.0
TH2_k127_8886464_6 PFAM Plasmid stabilisation system - - - 0.00000001144 58.0
TH2_k127_8887262_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 596.0
TH2_k127_8887262_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 377.0
TH2_k127_8887262_2 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 350.0
TH2_k127_8887262_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 344.0
TH2_k127_8887262_4 Aminotransferase, class I K14267 - 2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 332.0
TH2_k127_8887262_5 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000007509 216.0
TH2_k127_8887262_6 RDD family - - - 0.00000000000000000000000000000000000000000000000000000005845 199.0
TH2_k127_8887262_7 - - - - 0.00000000000002518 75.0
TH2_k127_888801_0 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007745 446.0
TH2_k127_888801_1 TIGRFAM Lytic murein transglycosylase B K08305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000837 322.0
TH2_k127_888801_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000003008 186.0
TH2_k127_900300_0 Tyrosine-protein kinase, subgroup, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 421.0
TH2_k127_900300_1 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002355 275.0
TH2_k127_900300_2 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000001285 203.0
TH2_k127_900300_3 - - - - 0.000000000000000000004672 98.0
TH2_k127_926628_0 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 389.0
TH2_k127_926628_1 PFAM Glycosyl transferase, group 1 K02844 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 359.0
TH2_k127_926628_2 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 342.0
TH2_k127_926628_3 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 333.0
TH2_k127_926628_4 glycosyl transferase family 2 K12984 - - 0.000000000000000000000000000000000000000000002002 168.0
TH2_k127_926628_5 -O-antigen - - - 0.00000000000000001544 96.0
TH2_k127_94833_0 pdz dhr glgf - - - 0.0 1391.0
TH2_k127_949828_0 BT1 family - - - 5.695e-217 688.0
TH2_k127_949828_1 COG1943 Transposase and inactivated derivatives K07491 - - 0.000000000000000002918 85.0
TH2_k127_949828_2 Belongs to the heat shock protein 70 family - - - 0.000000000004151 68.0
TH2_k127_964948_0 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 8.27e-198 627.0
TH2_k127_964948_1 - - - - 0.000000000000000000000000001618 115.0
TH2_k127_993289_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 602.0
TH2_k127_993289_1 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 575.0
TH2_k127_993289_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000000000007307 198.0
TH2_k127_999723_0 PFAM Xylulose 5-phosphate Fructose 6-phosphate phosphoketolase, N-terminal K01621 GO:0003674,GO:0003824,GO:0008150,GO:0009758 4.1.2.22,4.1.2.9 0.0 1428.0
TH2_k127_999723_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 401.0
TH2_k127_999723_2 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 303.0
TH2_k127_999723_3 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000001823 161.0