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Overview

ID MAG03973
Name TLS1_bin.11
Sample SMP0103
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Nitrospiria
Order Nitrospirales
Family Nitrospiraceae
Genus Nitrospira_D
Species Nitrospira_D sp041742455
Assembly information
Completeness (%) 98.86
Contamination (%) 5.77
GC content (%) 54.0
N50 (bp) 9,598
Genome size (bp) 4,503,716

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4017

Gene name Description KEGG GOs EC E-value Score Sequence
TLS1_k127_1003570_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 411.0
TLS1_k127_1003570_1 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000005147 250.0
TLS1_k127_1003570_2 PFAM response regulator receiveR - - - 0.00000000000000000000000000000000000000000000000000001195 192.0
TLS1_k127_1003570_3 Diguanylate cyclase - - - 0.000000000000000000000000000006732 136.0
TLS1_k127_1003570_4 Belongs to the UPF0337 (CsbD) family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000008327 85.0
TLS1_k127_1003570_5 Belongs to the UPF0337 (CsbD) family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000003043 86.0
TLS1_k127_1003570_7 UPF0391 membrane protein - - - 0.00000000000009344 72.0
TLS1_k127_1003570_8 Beta/Gamma crystallin - - - 0.00000005216 61.0
TLS1_k127_1003570_9 Belongs to the peptidase M50B family - - - 0.00001841 53.0
TLS1_k127_1015648_0 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 301.0
TLS1_k127_1029659_0 Nitrite and sulphite reductase 4Fe-4S domain K00362,K00392 - 1.7.1.15,1.8.7.1 0.0 1290.0
TLS1_k127_1029659_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 5.749e-316 975.0
TLS1_k127_1029659_2 sulfate adenylyltransferase (ATP) activity K00860,K00955,K00956 - 2.7.1.25,2.7.7.4 1.392e-305 945.0
TLS1_k127_1029659_3 sulfate reduction K00390,K00957 - 1.8.4.10,1.8.4.8,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 506.0
TLS1_k127_1029659_4 Glycosyl transferase family, a/b domain K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 447.0
TLS1_k127_1029659_5 sulfate reduction K00390,K00860 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8,2.7.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 376.0
TLS1_k127_1029659_6 2 iron, 2 sulfur cluster binding K04487,K13643 - 2.8.1.7 0.000000000000000000000000000000000000000000001596 168.0
TLS1_k127_1029659_7 sequence-specific DNA binding K03557,K07712 GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000005136 159.0
TLS1_k127_1029659_8 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000000000001632 149.0
TLS1_k127_104408_0 DNA methylase K03427 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 542.0
TLS1_k127_104408_1 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 361.0
TLS1_k127_104408_2 Type I restriction modification DNA specificity domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 322.0
TLS1_k127_104408_3 Protein conserved in bacteria K01153 - 3.1.21.3 0.0000000000000000000000000000000000000003451 164.0
TLS1_k127_104408_4 site-specific DNA-methyltransferase (adenine-specific) activity K03427 - 2.1.1.72 0.00000000000000000000000000359 124.0
TLS1_k127_104408_5 - - - - 0.000000001835 58.0
TLS1_k127_1044289_0 Domain of unknown function (DUF4277) - - - 0.00000000000000000000000000000000000000000000000007491 198.0
TLS1_k127_1044289_1 Tn3 transposase DDE domain - - - 0.000000000002695 69.0
TLS1_k127_1048403_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 3.891e-198 626.0
TLS1_k127_1048403_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 568.0
TLS1_k127_1048403_2 general secretion pathway protein K10927 - - 0.000000000000000000000000000000000000000000000000000000000004553 215.0
TLS1_k127_1048403_5 PFAM Fimbrial assembly family protein K02461,K02662,K02663,K12289 - - 0.000002578 49.0
TLS1_k127_1055285_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 9.956e-250 774.0
TLS1_k127_1055285_1 Amino acid permease K03294 - - 2.901e-233 730.0
TLS1_k127_1055285_10 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 352.0
TLS1_k127_1055285_11 protein secretion K03116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002246 247.0
TLS1_k127_1055285_12 PilZ domain K02676 - - 0.000000000000000000000000000000000000000000000000000000000000000000009327 237.0
TLS1_k127_1055285_13 PilZ domain K02676 - - 0.00000000000000000000000000000000000000000000000000000000000000003245 227.0
TLS1_k127_1055285_15 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000004174 171.0
TLS1_k127_1055285_16 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000000000000000000000000000000000003883 166.0
TLS1_k127_1055285_17 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000000000000000000424 165.0
TLS1_k127_1055285_18 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000000000000000000000000006947 131.0
TLS1_k127_1055285_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 1.405e-222 705.0
TLS1_k127_1055285_22 deoxyhypusine monooxygenase activity K05386 - - 0.000000000001374 74.0
TLS1_k127_1055285_24 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K10936,K16079 - - 0.00003355 52.0
TLS1_k127_1055285_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 604.0
TLS1_k127_1055285_4 proline dipeptidase activity K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 570.0
TLS1_k127_1055285_5 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 501.0
TLS1_k127_1055285_6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 470.0
TLS1_k127_1055285_7 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 462.0
TLS1_k127_1055285_8 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 389.0
TLS1_k127_1055285_9 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 354.0
TLS1_k127_1058715_0 NADH-quinone oxidoreductase K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001464 236.0
TLS1_k127_1058715_1 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000001213 184.0
TLS1_k127_1061694_0 cellulase activity K18197 - 4.2.2.23 0.000000000000000000000000000000000000000003411 165.0
TLS1_k127_1063914_0 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03673 GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071236,GO:0140096 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001489 276.0
TLS1_k127_1063914_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.0000000000000000005921 90.0
TLS1_k127_1063914_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000615 75.0
TLS1_k127_1067627_0 - - - - 0.0000000000000000000000002164 114.0
TLS1_k127_1070176_0 ABC transporter K06020 - 3.6.3.25 0.0 1050.0
TLS1_k127_1070176_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 487.0
TLS1_k127_1070176_2 coenzyme F420 binding K07226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007729 430.0
TLS1_k127_1070176_3 dTDP-4-dehydrorhamnose reductase activity K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 353.0
TLS1_k127_1070176_4 Protein of unknown function (DUF1295) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 304.0
TLS1_k127_1070176_5 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000003345 255.0
TLS1_k127_1070176_7 ribonuclease activity - - - 0.0000000000000000000000000000000000000005919 153.0
TLS1_k127_1070176_9 SpoVT / AbrB like domain - - - 0.00001791 49.0
TLS1_k127_1074969_0 - - - - 0.00000000000000000000000000000000000000000000000000000000007226 224.0
TLS1_k127_1074969_1 PFAM Transposase, Rhodopirellula-type - - - 0.0000000001803 62.0
TLS1_k127_107515_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.026e-302 936.0
TLS1_k127_107515_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 3.485e-207 657.0
TLS1_k127_107515_10 Autoinducer binding domain - - - 0.000000000000000000000000000000007593 138.0
TLS1_k127_107515_11 Histidine kinase K07682 GO:0000166,GO:0000287,GO:0001666,GO:0003032,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009593,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0019825,GO:0019826,GO:0020037,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0036293,GO:0040007,GO:0042165,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0046872,GO:0046906,GO:0048037,GO:0050896,GO:0051606,GO:0051775,GO:0051776,GO:0070025,GO:0070026,GO:0070482,GO:0070483,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.000000000000000000000000000175 125.0
TLS1_k127_107515_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 496.0
TLS1_k127_107515_3 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 481.0
TLS1_k127_107515_4 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 472.0
TLS1_k127_107515_5 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 330.0
TLS1_k127_107515_6 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 313.0
TLS1_k127_107515_7 Glyoxalase-like domain K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000795 220.0
TLS1_k127_107515_8 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000103 183.0
TLS1_k127_107515_9 Acyl-homoserine-lactone synthase K13060,K13061,K18096,K20248,K20249,K20250 - 2.3.1.184,2.3.1.228,2.3.1.229 0.00000000000000000000000000000000000000000001058 171.0
TLS1_k127_1079045_0 hmm pf02371 K07486 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 349.0
TLS1_k127_1079997_0 AcrB/AcrD/AcrF family - - - 0.0 1678.0
TLS1_k127_1079997_11 Sterol carrier protein - - - 0.000000000000000000000000000000000000037 147.0
TLS1_k127_1079997_2 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 520.0
TLS1_k127_1079997_3 Protein of unknown function (DUF2914) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 475.0
TLS1_k127_1079997_4 Glycosyltransferase family 28 N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009494 389.0
TLS1_k127_1079997_5 nitric oxide dioxygenase activity K00523 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 306.0
TLS1_k127_1079997_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002892 238.0
TLS1_k127_1079997_7 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K00797,K01611 - 2.5.1.16,4.1.1.50 0.000000000000000000000000000000000000000000000000000000000199 205.0
TLS1_k127_1079997_9 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000003926 177.0
TLS1_k127_1080330_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2536.0
TLS1_k127_1080330_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1677.0
TLS1_k127_1080330_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 472.0
TLS1_k127_1080330_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 402.0
TLS1_k127_1080330_4 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 318.0
TLS1_k127_1080330_5 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001221 250.0
TLS1_k127_1080330_6 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000001002 84.0
TLS1_k127_1085037_0 DEAD/DEAH box helicase - - - 5.294e-262 824.0
TLS1_k127_1085037_1 Protein involved in outer membrane biogenesis K07289 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008702 604.0
TLS1_k127_1085037_10 DDE superfamily endonuclease K07494 - - 0.00000000000000000000000000000000000000005717 157.0
TLS1_k127_1085037_11 PIN domain K18828 - - 0.0000000000000000000000000000000001047 136.0
TLS1_k127_1085037_12 Domain of unknown function (DUF4143) - - - 0.00000000000000000000000000000002139 128.0
TLS1_k127_1085037_13 Antidote-toxin recognition MazE, bacterial antitoxin K18829 - - 0.0000000000000000003501 89.0
TLS1_k127_1085037_14 DDE superfamily endonuclease K07494 - - 0.0000000000002196 71.0
TLS1_k127_1085037_15 Transposase K07494 - - 0.000000000002569 69.0
TLS1_k127_1085037_16 Transcriptional regulator K12146,K15836 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.000000002212 66.0
TLS1_k127_1085037_17 nucleic acid-binding protein contains PIN domain K07063 - - 0.0003798 44.0
TLS1_k127_1085037_18 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000706 49.0
TLS1_k127_1085037_2 Uncharacterized protein conserved in bacteria (DUF2130) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 567.0
TLS1_k127_1085037_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006234 415.0
TLS1_k127_1085037_4 Mur ligase middle domain protein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 347.0
TLS1_k127_1085037_5 Domain of unknown function (DUF1837) - - - 0.0000000000000000000000000000000000000000000000000000000000000003867 224.0
TLS1_k127_1085037_6 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000000000000000001375 195.0
TLS1_k127_1085037_7 Protein of unknown function (DUF1810) - - - 0.000000000000000000000000000000000000000000000000008255 184.0
TLS1_k127_1085037_8 Domain of unknown function (DUF1837) - - - 0.00000000000000000000000000000000000000000000002203 173.0
TLS1_k127_1085037_9 peptidase K02557,K21471 - - 0.0000000000000000000000000000000000000000000001572 181.0
TLS1_k127_1085523_0 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 373.0
TLS1_k127_1085523_1 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001769 268.0
TLS1_k127_1088672_0 the current gene model (or a revised gene model) may contain a premature stop - - - 0.0000000000000000000000000000002449 125.0
TLS1_k127_1088672_1 COG NOG15344 non supervised orthologous group - - - 0.000000000000000000000000001786 111.0
TLS1_k127_1088672_2 COG NOG15344 non supervised orthologous group - - - 0.00000000000000004452 85.0
TLS1_k127_1088672_3 - - - - 0.000000000000004083 76.0
TLS1_k127_1088672_4 - - - - 0.0000001062 55.0
TLS1_k127_1099072_0 STAS-like domain of unknown function (DUF4325) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002368 520.0
TLS1_k127_1099072_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000001525 165.0
TLS1_k127_1099072_2 Protein of unknown function (DUF2283) - - - 0.000000002027 61.0
TLS1_k127_1108116_0 histidine kinase, dimerisation and phosphoacceptor region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005614 282.0
TLS1_k127_1108116_1 Domain of unknown function (DUF4386) - - - 0.000000000000000000000002993 107.0
TLS1_k127_1113807_0 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 359.0
TLS1_k127_1113807_1 peptidoglycan binding K03642 - - 0.00000000000000000000000000000000000000000000004881 181.0
TLS1_k127_1114562_0 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 293.0
TLS1_k127_1114562_1 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000001063 91.0
TLS1_k127_1116868_0 Belongs to the carbamoyltransferase HypF family K04656 - - 3.281e-231 741.0
TLS1_k127_1116868_1 PFAM Nickel-dependent hydrogenase, large subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000428 544.0
TLS1_k127_1116868_10 - - - - 0.00000000000000000000000006134 110.0
TLS1_k127_1116868_11 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000003871 105.0
TLS1_k127_1116868_12 Hydrogenase expression formation protein K04653 - - 0.000000000000000000002015 98.0
TLS1_k127_1116868_13 Protein of unknown function (DUF2283) - - - 0.00000000000000000008103 91.0
TLS1_k127_1116868_15 Hydrogenase/urease nickel incorporation, metallochaperone, hypA K04651 - - 0.000000000864 64.0
TLS1_k127_1116868_16 phage envelope protein - - - 0.0000003597 53.0
TLS1_k127_1116868_17 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0008989 42.0
TLS1_k127_1116868_2 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 322.0
TLS1_k127_1116868_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000004616 212.0
TLS1_k127_1116868_4 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000000000000000006202 140.0
TLS1_k127_1116868_5 PFAM nuclease (SNase domain protein) - - - 0.00000000000000000000000000000000001996 141.0
TLS1_k127_1116868_6 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000000000000000001446 134.0
TLS1_k127_1116868_7 phage envelope protein - - - 0.000000000000000000000000000001307 123.0
TLS1_k127_1116868_8 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.000000000000000000000000009597 110.0
TLS1_k127_1116868_9 Hydrogenase maturation protease - - - 0.00000000000000000000000001944 115.0
TLS1_k127_1120336_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 486.0
TLS1_k127_1120336_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 436.0
TLS1_k127_1120336_2 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000292 217.0
TLS1_k127_1120336_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000006472 199.0
TLS1_k127_112495_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 597.0
TLS1_k127_112495_1 Histidine kinase K01120,K07315 - 3.1.3.3,3.1.4.17 0.00000000000000000000000000000000000000000000000000000000000000000005838 255.0
TLS1_k127_1128124_0 Putative oxalocrotonate tautomerase enzyme - - - 0.00000000000000000000000000000000000000000000000000003658 190.0
TLS1_k127_1128124_1 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000002139 175.0
TLS1_k127_1135196_0 cytochrome p450 - - - 2.197e-230 723.0
TLS1_k127_1135196_1 Phosphoserine phosphatase K02203 - 2.7.1.39,3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 318.0
TLS1_k127_1135196_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0001499 45.0
TLS1_k127_1135196_2 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 311.0
TLS1_k127_1135196_3 PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007028 282.0
TLS1_k127_1135196_4 metal cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001734 276.0
TLS1_k127_1135196_5 Ubiquinol--cytochrome c reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000006184 235.0
TLS1_k127_1135196_6 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000003376 198.0
TLS1_k127_1135196_9 Zn peptidase - - - 0.0000000000000000000000000000000000000001696 151.0
TLS1_k127_1149314_0 Transcriptional regulator K07013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001386 257.0
TLS1_k127_1149314_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000003725 206.0
TLS1_k127_1153556_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008315 439.0
TLS1_k127_1153556_1 von Willebrand factor (vWF) type A domain K02448 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003499 402.0
TLS1_k127_1153556_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000003133 219.0
TLS1_k127_115670_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 1.173e-283 876.0
TLS1_k127_115670_1 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 605.0
TLS1_k127_115670_2 - - - - 0.0000000000000000000000000000000005653 137.0
TLS1_k127_1168316_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 410.0
TLS1_k127_1168316_1 Domain of Unknown Function (DUF326) - - - 0.000000000000000000000000003207 116.0
TLS1_k127_1168330_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000004915 210.0
TLS1_k127_1168330_1 Phage integrase family - - - 0.00000000000000000000000011 113.0
TLS1_k127_1168330_2 - - - - 0.00000000000232 67.0
TLS1_k127_1175385_0 COGs COG3328 Transposase and inactivated derivatives - - - 0.00000000000000000000007825 105.0
TLS1_k127_117550_0 transposase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 406.0
TLS1_k127_117550_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.00000000000000000000000000001265 119.0
TLS1_k127_1186859_0 response regulator K02282 - - 0.00000000000000000000000000000000000000000000000000000000006166 212.0
TLS1_k127_1186859_1 response regulator K02282 - - 0.000000000000000000000000000000000000000000001396 173.0
TLS1_k127_1186859_2 Plasmid stabilization - - - 0.0000000000000001835 80.0
TLS1_k127_1202996_0 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000878 259.0
TLS1_k127_1202996_1 - - - - 0.00000000000000000000000000000000000000001023 155.0
TLS1_k127_1202996_3 - - - - 0.000000000000000000000000002829 113.0
TLS1_k127_1203470_0 Histidine kinase K07683 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000004146 199.0
TLS1_k127_1203470_1 response regulator K02282 - - 0.000000000000000000000000000000000000000000303 164.0
TLS1_k127_1215749_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006983 467.0
TLS1_k127_1215749_1 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 434.0
TLS1_k127_1215749_2 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001305 277.0
TLS1_k127_1215758_0 Dehydratase family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 496.0
TLS1_k127_1215758_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 332.0
TLS1_k127_1215758_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000005657 240.0
TLS1_k127_121869_0 Glucokinase K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 533.0
TLS1_k127_121869_1 Peptidase family M1 domain K08776 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008805 349.0
TLS1_k127_121869_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K00851,K00852,K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 329.0
TLS1_k127_121869_3 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000002943 234.0
TLS1_k127_1220695_0 TIGRFAM Potassium uptake protein TrkH K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 395.0
TLS1_k127_1220695_1 TrkA-C domain K03499 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000002935 232.0
TLS1_k127_1220695_2 PFAM IS1 transposase K07480 - - 0.0000000000000000000000000000000000000000000000000001774 188.0
TLS1_k127_1220695_3 Putative ATPase subunit of terminase (gpP-like) - - - 0.000000000000000000000000000000000000000002368 158.0
TLS1_k127_1221068_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 341.0
TLS1_k127_1229376_0 'glutamate synthase K00528,K03388 - 1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006522 516.0
TLS1_k127_1229376_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 408.0
TLS1_k127_1229376_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 369.0
TLS1_k127_1229376_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001063 281.0
TLS1_k127_1229376_5 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000001573 242.0
TLS1_k127_1229376_6 Glycoprotease family K14742 - - 0.000000000000000000000000000000000000000000000000000000002385 208.0
TLS1_k127_1229376_7 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000002066 169.0
TLS1_k127_1229376_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000001747 119.0
TLS1_k127_1229376_9 Protein of unknown function (DUF465) K09794 - - 0.00000000000000000000746 94.0
TLS1_k127_1230326_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001604 278.0
TLS1_k127_1230326_1 Shikimate kinase K00851 - 2.7.1.12 0.0000000000000000000000000000000000000001334 156.0
TLS1_k127_1230326_2 Histidine kinase - - - 0.0000000000000000000000006474 123.0
TLS1_k127_1230326_3 Protein of unknown function (DUF3175) - - - 0.0000000000000000004187 88.0
TLS1_k127_1230326_4 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.0000000000000001449 83.0
TLS1_k127_1246237_0 Homeodomain-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000286 263.0
TLS1_k127_1246237_1 NMT1-like family K02051 - - 0.0000008717 57.0
TLS1_k127_1249240_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 3.606e-227 711.0
TLS1_k127_1249240_1 Response regulator, receiver K20973 - 2.7.13.3 9.387e-201 650.0
TLS1_k127_1249240_10 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 360.0
TLS1_k127_1249240_11 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 295.0
TLS1_k127_1249240_12 response regulator, receiver K03413,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 294.0
TLS1_k127_1249240_13 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007663 290.0
TLS1_k127_1249240_14 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000002026 266.0
TLS1_k127_1249240_16 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000000000000000000000000000000000000000005494 227.0
TLS1_k127_1249240_17 - - - - 0.0000000000000000000000000000000000000000000000000000003384 194.0
TLS1_k127_1249240_18 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000000000002256 194.0
TLS1_k127_1249240_19 Ferredoxin - - - 0.0000000000000000000000000000000000000000000004251 168.0
TLS1_k127_1249240_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 584.0
TLS1_k127_1249240_20 Cytochrome c - - - 0.000000000000000000000000000000000000000003308 160.0
TLS1_k127_1249240_21 ribonucleoside-diphosphate reductase activity K07735 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000004141 166.0
TLS1_k127_1249240_22 - - - - 0.00000000000000000000000000000000000000001062 160.0
TLS1_k127_1249240_24 - - - - 0.0000000000000000000000000000000002682 138.0
TLS1_k127_1249240_25 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000000000102 126.0
TLS1_k127_1249240_27 beta-lactamase activity K07126 - - 0.0000000000000000000000001891 114.0
TLS1_k127_1249240_28 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 0.000000000000000000004757 95.0
TLS1_k127_1249240_29 Histidine kinase - - - 0.0000000000000000003429 92.0
TLS1_k127_1249240_3 alanine dehydrogenase activity K00259 GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003674 538.0
TLS1_k127_1249240_30 - - - - 0.0000299 48.0
TLS1_k127_1249240_4 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 522.0
TLS1_k127_1249240_5 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 512.0
TLS1_k127_1249240_6 Squalene/phytoene synthase K00801 - 2.5.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 458.0
TLS1_k127_1249240_7 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 445.0
TLS1_k127_1249240_9 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 431.0
TLS1_k127_1258316_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 2.307e-196 630.0
TLS1_k127_1258316_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000076 567.0
TLS1_k127_1258316_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 466.0
TLS1_k127_1258316_3 General secretion pathway protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000009573 210.0
TLS1_k127_1258316_4 Domain present in PSD-95, Dlg, and ZO-1/2. K02452 - - 0.000000000000000000000000001898 124.0
TLS1_k127_1258316_5 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000001435 59.0
TLS1_k127_1265164_0 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001979 282.0
TLS1_k127_1265164_1 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000009292 216.0
TLS1_k127_1265164_2 UPF0391 membrane protein - - - 0.0000000000004063 70.0
TLS1_k127_1269006_0 Transposase IS66 family K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000929 351.0
TLS1_k127_1275312_0 PFAM binding-protein-dependent transport systems inner membrane component K02046,K15496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007855 420.0
TLS1_k127_1275312_1 sulfate ABC transporter K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 389.0
TLS1_k127_1275312_2 Extracellular solute-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 286.0
TLS1_k127_1275312_3 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000002464 232.0
TLS1_k127_1275312_4 Uncharacterized protein conserved in bacteria (DUF2325) - - - 0.00000000000000000000005397 101.0
TLS1_k127_1275733_0 Non-ribosomal peptide synthetase modules and related - - - 3.917e-236 763.0
TLS1_k127_1276070_0 Type II/IV secretion system protein K02454,K02652 - - 3.801e-297 919.0
TLS1_k127_1276070_1 Type ii and iii secretion system protein K02453 - - 4.972e-276 869.0
TLS1_k127_1276070_2 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 529.0
TLS1_k127_1276070_3 general secretion pathway protein K02456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002604 256.0
TLS1_k127_1276070_4 Pilus assembly protein K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000003167 235.0
TLS1_k127_1276070_5 general secretion pathway protein K02456 - - 0.0000000000000000000000000000000000000000000000001901 178.0
TLS1_k127_1276070_6 Putative peptidoglycan binding domain - - - 0.000002022 59.0
TLS1_k127_1277328_0 alpha-ribazole phosphatase activity K00850,K21071 - 2.7.1.11,2.7.1.90 0.0 1084.0
TLS1_k127_1277328_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005824 547.0
TLS1_k127_1277328_2 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 317.0
TLS1_k127_1277328_3 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 302.0
TLS1_k127_1277328_4 - - - - 0.0000000000000000000000000006813 113.0
TLS1_k127_1277328_5 COGs COG0790 FOG TPR repeat SEL1 subfamily K07126 - - 0.000000000000000001775 92.0
TLS1_k127_1277328_7 methyltransferase - - - 0.00000004023 57.0
TLS1_k127_1277328_8 - - - - 0.00000006016 57.0
TLS1_k127_1277328_9 Uncharacterized protein conserved in bacteria (DUF2314) - - - 0.00006355 52.0
TLS1_k127_1297264_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 334.0
TLS1_k127_1307509_0 Formate--tetrahydrofolate ligase K01938 GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 3.922e-265 826.0
TLS1_k127_1307509_1 succinyl-diaminopimelate desuccinylase activity - - - 2.336e-242 754.0
TLS1_k127_1307509_2 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 475.0
TLS1_k127_1307509_3 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 426.0
TLS1_k127_1307509_4 stress-induced mitochondrial fusion K04087 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 332.0
TLS1_k127_1307509_5 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007766 241.0
TLS1_k127_1307509_7 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000004041 105.0
TLS1_k127_1309995_0 PHD-finger - - - 0.00001088 55.0
TLS1_k127_1309995_1 DDE superfamily endonuclease - - - 0.0004119 48.0
TLS1_k127_1315701_0 Uncharacterized ACR, YdiU/UPF0061 family K08997 - - 5.05e-252 784.0
TLS1_k127_1315701_1 Alpha/beta hydrolase family K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 329.0
TLS1_k127_1315701_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02022,K06147,K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 333.0
TLS1_k127_1315701_3 thiolester hydrolase activity K06889,K07000 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 321.0
TLS1_k127_1315701_4 PFAM ABC transporter related K06148 - - 0.00000000000000000000000000000000000000000000000000000000007104 207.0
TLS1_k127_1315701_5 FAD binding domain - - - 0.0000000000000000000000000000000000000003115 152.0
TLS1_k127_1315701_7 FAD binding domain - - - 0.0003039 45.0
TLS1_k127_1315701_8 Uncharacterized conserved protein (DUF2294) - - - 0.0008989 42.0
TLS1_k127_1321729_0 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001638 274.0
TLS1_k127_1321729_1 depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002918 270.0
TLS1_k127_1321729_2 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0005948 42.0
TLS1_k127_1324904_0 - - - - 0.00000000000000000000002217 114.0
TLS1_k127_1336531_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 578.0
TLS1_k127_1336531_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00520 - 1.16.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000004914 259.0
TLS1_k127_1336531_10 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.00000397 49.0
TLS1_k127_1336531_2 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000003601 180.0
TLS1_k127_1336531_3 YCII-related domain - - - 0.000000000000000000000000009627 112.0
TLS1_k127_1336531_4 Glyoxalase-like domain K04750 - - 0.00000000000000000000001044 102.0
TLS1_k127_1336531_5 Dodecin K09165 - - 0.0000000000000000000009558 96.0
TLS1_k127_1336531_6 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 0.000000000000000009071 86.0
TLS1_k127_1336531_7 RNA signal recognition particle 4.5S RNA - - - 0.0000000000000000314 82.0
TLS1_k127_1336531_8 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00520 - 1.16.1.1 0.0000000000000001894 81.0
TLS1_k127_1336531_9 - - - - 0.0000000000002113 77.0
TLS1_k127_134107_0 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 597.0
TLS1_k127_134107_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 535.0
TLS1_k127_134107_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 514.0
TLS1_k127_134107_3 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 432.0
TLS1_k127_134107_4 Proto-chlorophyllide reductase 57 kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 299.0
TLS1_k127_134107_5 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000001555 249.0
TLS1_k127_134107_6 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000001425 229.0
TLS1_k127_134107_8 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000002997 109.0
TLS1_k127_134107_9 NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - 0.00000000000000000008007 103.0
TLS1_k127_1351146_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 477.0
TLS1_k127_1351146_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 349.0
TLS1_k127_1351146_2 - - - - 0.0000000000000000000000000000000000000000005555 159.0
TLS1_k127_1351265_0 Galactose oxidase, central domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 374.0
TLS1_k127_1351265_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 374.0
TLS1_k127_1351265_10 - - - - 0.0000000001685 66.0
TLS1_k127_1351265_11 - - - - 0.0000000005547 64.0
TLS1_k127_1351265_12 WD-40 repeat - - - 0.00000006843 65.0
TLS1_k127_1351265_13 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00002225 51.0
TLS1_k127_1351265_2 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000299 226.0
TLS1_k127_1351265_3 CAAX protease self-immunity K07052 - - 0.000000000000000000000000001283 121.0
TLS1_k127_1351265_5 - - - - 0.00000000000000000000005491 105.0
TLS1_k127_1351265_6 - - - - 0.0000000000000000000005891 98.0
TLS1_k127_1351265_7 cellulose binding K01179 - 3.2.1.4 0.000000000000000007286 99.0
TLS1_k127_1351265_8 Galactose oxidase, central domain - - - 0.00000000000004093 72.0
TLS1_k127_1351265_9 coenzyme F420 binding K07226 - - 0.00000000001729 66.0
TLS1_k127_1361443_0 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 506.0
TLS1_k127_1361443_1 biosynthesis protein E K06139 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007727 457.0
TLS1_k127_1361443_10 Protein of unknown function (DUF1328) - - - 0.000003592 52.0
TLS1_k127_1361443_2 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 331.0
TLS1_k127_1361443_3 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 302.0
TLS1_k127_1361443_4 - - - - 0.000000000000000000000000000000000000000000000004099 179.0
TLS1_k127_1361443_5 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000000004724 170.0
TLS1_k127_1361443_6 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000007252 177.0
TLS1_k127_1361443_7 - - - - 0.0000000000000000000000001195 112.0
TLS1_k127_1361443_8 pyrroloquinoline quinone biosynthesis protein D K06138 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.000000002534 63.0
TLS1_k127_1369227_0 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000000000000000004989 140.0
TLS1_k127_1369227_1 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000001835 64.0
TLS1_k127_1374834_0 - - - - 0.000000000000000000000000000001081 122.0
TLS1_k127_1374834_1 - - - - 0.00000000000000000000000000001852 119.0
TLS1_k127_1374834_2 - - - - 0.0000000000000000000006009 96.0
TLS1_k127_1374834_3 - - - - 0.000000000000000000001225 95.0
TLS1_k127_1374834_5 - - - - 0.0009594 44.0
TLS1_k127_139432_0 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 497.0
TLS1_k127_139432_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000131 208.0
TLS1_k127_139432_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000008683 128.0
TLS1_k127_139432_3 Fic/DOC family K07341 - - 0.0000000000000000000000000000003505 126.0
TLS1_k127_139432_4 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000005637 104.0
TLS1_k127_139432_5 PFAM SpoVT AbrB K07172,K18842 - - 0.0000000000003154 74.0
TLS1_k127_1402532_0 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005424 266.0
TLS1_k127_1406722_0 PFAM Copper resistance D K07245 - - 2.302e-246 779.0
TLS1_k127_1406722_1 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 284.0
TLS1_k127_1406722_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000944 237.0
TLS1_k127_1406722_3 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000001876 235.0
TLS1_k127_1406722_4 - - - - 0.000000000000000000000000000000000000000000000000000000000001711 215.0
TLS1_k127_1406722_5 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.00000000000000000000000000000000000000000000000000000009612 198.0
TLS1_k127_1406722_6 - - - - 0.0000000000000000000000000000000000000000003139 165.0
TLS1_k127_1406722_7 PFAM Copper resistance protein CopC K07156 - - 0.000000000000000000000000000000000000000005342 158.0
TLS1_k127_141266_0 cobalamin binding K21089,K21972,K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 317.0
TLS1_k127_141266_1 PFAM NapC NirT cytochrome c K02569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001713 272.0
TLS1_k127_141638_0 acr, cog1565 K00412,K00971,K02275,K02389,K03177,K17624 - 1.9.3.1,2.7.7.13,3.2.1.97,5.4.99.25 7.723e-209 658.0
TLS1_k127_141638_1 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000657 433.0
TLS1_k127_141638_2 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000297 230.0
TLS1_k127_141638_3 anaphase-promoting complex-dependent catabolic process - - - 0.00000000000000000000000000000000000000000000000000001714 195.0
TLS1_k127_141638_4 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.000000000000000000000000000006384 121.0
TLS1_k127_14188_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K02660 - - 8.044e-218 693.0
TLS1_k127_14188_1 Signal transducing histidine kinase, homodimeric domain K02487,K03407,K06596 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008448 499.0
TLS1_k127_14188_2 nuclear chromosome segregation K02666,K03497,K19622 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002624 282.0
TLS1_k127_14188_3 cheY-homologous receiver domain K02658 - - 0.0000000000000000000000000000000000000000000000000000000006162 204.0
TLS1_k127_14188_4 - - - - 0.0000000000000000000000000000000000000001042 153.0
TLS1_k127_14188_5 chemotaxis K03408,K03415 - - 0.0000000000000000000000000000000005018 137.0
TLS1_k127_14188_6 chemotaxis K02659,K03408,K03415,K11524 - - 0.0000000000000000000000000001687 121.0
TLS1_k127_14188_7 - - - - 0.00000000000005347 77.0
TLS1_k127_1449254_0 Domain of unknown function (DUF4105) - - - 4.058e-306 954.0
TLS1_k127_1449254_1 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 400.0
TLS1_k127_1449254_2 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 372.0
TLS1_k127_1449254_3 Protein of unknown function (DUF3015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002404 262.0
TLS1_k127_1449254_5 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000001724 74.0
TLS1_k127_1449254_6 Domain of unknown function (DUF3332) - - - 0.000000000001511 75.0
TLS1_k127_1449254_7 Phosphoesterase K07095 - - 0.000004044 51.0
TLS1_k127_1449254_8 TRL-like protein family - - - 0.0005076 46.0
TLS1_k127_146044_0 Domain of unknown function (DUF3459) K01236 - 3.2.1.141 2.25e-221 704.0
TLS1_k127_146044_1 Sucrose-6F-phosphate phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 572.0
TLS1_k127_146044_10 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000001305 236.0
TLS1_k127_146044_11 PFAM Aminotransferase class-V K04127,K11325 - 5.1.1.17 0.00000000000000000000000000000000007008 149.0
TLS1_k127_146044_12 Domain of unknown function (DUF427) - - - 0.00000000000000000000000000000004364 133.0
TLS1_k127_146044_13 - - - - 0.000000000000000000000000001558 125.0
TLS1_k127_146044_14 Mechanosensitive ion channel - - - 0.000000022 66.0
TLS1_k127_146044_2 PFAM FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 567.0
TLS1_k127_146044_3 PFAM Amylo-alpha-16-glucosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 519.0
TLS1_k127_146044_4 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 434.0
TLS1_k127_146044_5 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 362.0
TLS1_k127_146044_6 PFAM ABC transporter related K05847 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 304.0
TLS1_k127_146044_7 ABC-type glycine betaine transport system K05845 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 308.0
TLS1_k127_146044_8 glycine betaine transport K05845,K05846 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005579 259.0
TLS1_k127_146044_9 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000001318 246.0
TLS1_k127_149177_0 B12 binding domain - - - 7.14e-302 931.0
TLS1_k127_149177_2 PIN domain - - - 0.0000000000000000000000000000000000000000000166 166.0
TLS1_k127_149177_3 positive regulation of growth - - - 0.0000000000000000000000005618 108.0
TLS1_k127_149177_4 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000000000000003445 96.0
TLS1_k127_149177_5 Putative transposase of IS4/5 family (DUF4096) - - - 0.000000000442 61.0
TLS1_k127_149177_6 amino acid - - - 0.000000784 53.0
TLS1_k127_149177_7 PFAM SpoVT AbrB like domain K07172 - - 0.00001458 51.0
TLS1_k127_1495266_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.225e-279 865.0
TLS1_k127_1495266_2 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000004403 155.0
TLS1_k127_1495266_3 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.000000000000000000000000000000000000002859 152.0
TLS1_k127_1498915_0 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000000005975 235.0
TLS1_k127_1498915_1 Mo-molybdopterin cofactor metabolic process K03636 - - 0.00000000000000000000000000004188 125.0
TLS1_k127_1498915_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000002629 88.0
TLS1_k127_1500320_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 4.558e-246 766.0
TLS1_k127_1500320_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.481e-240 747.0
TLS1_k127_1500320_2 Acts as a magnesium transporter K06213 - - 1.762e-223 701.0
TLS1_k127_1500320_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 433.0
TLS1_k127_1500320_4 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 286.0
TLS1_k127_1500320_5 cell cycle K05589 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301,GO:0071944 - 0.0000000000000000000006331 99.0
TLS1_k127_1518331_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.541e-274 852.0
TLS1_k127_1518331_1 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 1.42e-242 754.0
TLS1_k127_1518331_10 Bacterial protein of unknown function (DUF937) - - - 0.00000000000000000000000000000000000000000005637 164.0
TLS1_k127_1518331_11 Cytochrome c K00405 - - 0.000000000000000000000000000000000000000002175 161.0
TLS1_k127_1518331_2 twitching motility protein K02670 - - 6.821e-213 665.0
TLS1_k127_1518331_3 Evidence 2b Function of strongly homologous gene - - - 4.008e-210 656.0
TLS1_k127_1518331_4 Type II/IV secretion system protein K02669 - - 7.099e-202 633.0
TLS1_k127_1518331_5 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 489.0
TLS1_k127_1518331_6 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 482.0
TLS1_k127_1518331_7 Histidyl-tRNA synthetase K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 428.0
TLS1_k127_1518331_8 cell envelope organization K05807,K08309 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 287.0
TLS1_k127_1518331_9 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000001115 225.0
TLS1_k127_1558651_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0 1106.0
TLS1_k127_1558651_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.78e-302 934.0
TLS1_k127_1558651_10 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000000000000000001857 185.0
TLS1_k127_1558651_11 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000174 157.0
TLS1_k127_1558651_12 Protein conserved in bacteria K09764 - - 0.00000000000000000000000000000000377 130.0
TLS1_k127_1558651_13 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000006185 132.0
TLS1_k127_1558651_2 polyribonucleotide nucleotidyltransferase activity K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 3.652e-247 781.0
TLS1_k127_1558651_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 1.481e-210 666.0
TLS1_k127_1558651_4 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 547.0
TLS1_k127_1558651_5 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 386.0
TLS1_k127_1558651_6 Aminotransferase class I and II K14261 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008404 330.0
TLS1_k127_1558651_8 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 318.0
TLS1_k127_1575688_0 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 384.0
TLS1_k127_1575688_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 376.0
TLS1_k127_1575688_2 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 299.0
TLS1_k127_1575688_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000002836 227.0
TLS1_k127_1575688_4 DNA integration - - - 0.00000000000000000000004909 104.0
TLS1_k127_1595546_0 DJ-1/PfpI family - - - 0.000000000000000000000000000000000000000000000000000000000000008844 225.0
TLS1_k127_1597305_0 transposition, RNA-mediated - - - 0.0000001618 57.0
TLS1_k127_1605308_0 - - - - 0.0000000000000000000000000000001432 127.0
TLS1_k127_1605308_1 - - - - 0.0000000008919 62.0
TLS1_k127_1605308_3 - - - - 0.00003149 46.0
TLS1_k127_1605308_4 - - - - 0.0001744 49.0
TLS1_k127_1612957_0 4 iron, 4 sulfur cluster binding K00113,K00176,K05524,K13795,K13796 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 610.0
TLS1_k127_1612957_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009177 325.0
TLS1_k127_1612957_2 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 280.0
TLS1_k127_1612957_3 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001212 238.0
TLS1_k127_1612957_4 AMP binding - - - 0.0000000000000000000000000000000000000006704 151.0
TLS1_k127_1612957_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000388 154.0
TLS1_k127_161858_0 radical SAM domain protein - - - 0.0 1087.0
TLS1_k127_161858_1 PhoQ Sensor - - - 6.378e-246 790.0
TLS1_k127_161858_10 Ferredoxin - - - 0.0000000000000000000000000000000000000000000000000000000002145 203.0
TLS1_k127_161858_11 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000001443 198.0
TLS1_k127_161858_12 Thiamine-binding protein - - - 0.000000000000000000000000000000000000000000001066 168.0
TLS1_k127_161858_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000000000001046 132.0
TLS1_k127_161858_2 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009456 515.0
TLS1_k127_161858_3 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 506.0
TLS1_k127_161858_4 isomerase activity K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 443.0
TLS1_k127_161858_5 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 360.0
TLS1_k127_161858_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 332.0
TLS1_k127_161858_7 precorrin-2 dehydrogenase activity K02302,K02304 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 318.0
TLS1_k127_161858_8 Mo-molybdopterin cofactor metabolic process K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000203 271.0
TLS1_k127_161858_9 PFAM AIG2 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003379 239.0
TLS1_k127_1651248_0 Uracil DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000000003599 183.0
TLS1_k127_1651248_1 LexA-binding, inner membrane-associated putative hydrolase - - - 0.000000000000000000000000000000000000000002422 161.0
TLS1_k127_1651248_2 - - - - 0.000000001519 62.0
TLS1_k127_1675537_0 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000002752 209.0
TLS1_k127_1675537_1 PFAM Plasmid stabilisation system K19092 - - 0.0000000000000000000000000000000000000000000000172 172.0
TLS1_k127_1675537_2 addiction module antidote protein, CC2985 K07746 - - 0.0000000000000000000000000000000009928 132.0
TLS1_k127_1675537_3 energy transducer activity K03832 - - 0.0000000000000000001225 94.0
TLS1_k127_1675537_4 PepSY-associated TM region - - - 0.0000001072 59.0
TLS1_k127_1675537_5 Putative regulatory protein - - - 0.0009642 46.0
TLS1_k127_1678500_0 Sulfate transporter subunit K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002271 277.0
TLS1_k127_1711537_0 response regulator K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009981 280.0
TLS1_k127_1711537_1 Histidine kinase K07683 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000004474 258.0
TLS1_k127_1711537_2 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.0000001776 59.0
TLS1_k127_1778053_0 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 539.0
TLS1_k127_1778053_1 lactoylglutathione lyase activity K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000001785 250.0
TLS1_k127_1778053_2 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002432 249.0
TLS1_k127_1778053_3 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000002395 181.0
TLS1_k127_1778053_4 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.0000000000000000000000000002838 117.0
TLS1_k127_1778053_5 - - - - 0.00000000000000007055 88.0
TLS1_k127_1783103_0 protein histidine kinase activity K02484,K07640,K07643,K07645,K07649,K19609 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 480.0
TLS1_k127_1783103_1 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 358.0
TLS1_k127_1783103_2 ferredoxin-thioredoxin reductase activity K17892 GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015979,GO:0016491,GO:0016730,GO:0022900,GO:0030385,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 1.8.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000289 238.0
TLS1_k127_1783103_3 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000000005757 196.0
TLS1_k127_1783103_4 von Willebrand factor (vWF) type A domain K02448 - - 0.000000000000000000000000000000000001179 146.0
TLS1_k127_1783103_5 - - - - 0.000002655 57.0
TLS1_k127_1794640_0 sodium:proton antiporter activity K03316 - - 1.672e-206 648.0
TLS1_k127_1794640_1 Ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007552 282.0
TLS1_k127_1794640_2 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000146 96.0
TLS1_k127_1794952_0 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008295 316.0
TLS1_k127_1794952_1 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000001956 221.0
TLS1_k127_1801968_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 299.0
TLS1_k127_1801968_1 Belongs to the UPF0145 family - - - 0.000000000000000000000000000000000000006589 151.0
TLS1_k127_1801968_2 transposase, IS204 IS1001 IS1096 IS1165 family protein - - - 0.000001343 60.0
TLS1_k127_1802861_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000002081 249.0
TLS1_k127_1802861_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K00184 - - 0.0000000000000002705 81.0
TLS1_k127_1885215_0 AbgT putative transporter family K12942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 406.0
TLS1_k127_1922065_0 Rhodopirellula transposase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 359.0
TLS1_k127_1922065_1 COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid K00101,K16422 - 1.1.2.3,1.1.3.46 0.000000002294 58.0
TLS1_k127_194132_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 1977.0
TLS1_k127_194132_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.0000000000000000000000000000000000000000000009314 174.0
TLS1_k127_19938_0 sodium:proton antiporter activity K03316 - - 3.639e-236 740.0
TLS1_k127_19938_1 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 536.0
TLS1_k127_19938_2 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 509.0
TLS1_k127_19938_3 Sodium:dicarboxylate symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009282 486.0
TLS1_k127_19938_4 tRNA processing K04075,K14058,K21947 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.1.15,6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 425.0
TLS1_k127_19938_5 - - - - 0.000000000000000000000000000000000000000000000000000000001882 207.0
TLS1_k127_19938_6 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.00000000000000000000000000000000000000000003007 167.0
TLS1_k127_19938_7 Belongs to the peptidase S1B family K07114 - - 0.00000000000000000000000000000000004895 153.0
TLS1_k127_19938_8 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.000000000000000000000000000003299 121.0
TLS1_k127_2021746_0 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 416.0
TLS1_k127_2021746_1 Choline/ethanolamine kinase K18844 - - 0.00000000000000000000000000000003845 127.0
TLS1_k127_2030532_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 1.354e-259 818.0
TLS1_k127_2030532_1 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 329.0
TLS1_k127_2030532_2 Glycogen debranching enzyme N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000004528 237.0
TLS1_k127_2030532_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000000000000002207 227.0
TLS1_k127_2030532_4 - - - - 0.000000000000004878 79.0
TLS1_k127_2033773_0 NUBPL iron-transfer P-loop NTPase K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 313.0
TLS1_k127_2042824_0 Histidine kinase - - - 0.00000000000000000000000000000000006741 146.0
TLS1_k127_2042824_1 Y_Y_Y domain - - - 0.0000000000000004855 89.0
TLS1_k127_2042824_2 Histidine kinase - - - 0.0000000000002376 73.0
TLS1_k127_2042824_3 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000008347 74.0
TLS1_k127_2042824_4 Histidine kinase - - - 0.000004152 55.0
TLS1_k127_2052558_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 9.945e-268 828.0
TLS1_k127_2052558_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 285.0
TLS1_k127_2052558_10 iron dependent repressor K01356,K03709 - 3.4.21.88 0.0000000000000000000000000000000002695 134.0
TLS1_k127_2052558_11 Type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.0000002565 58.0
TLS1_k127_2052558_2 peptidyl-serine autophosphorylation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003439 286.0
TLS1_k127_2052558_3 Alcohol dehydrogenase GroES-like domain K13979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008326 275.0
TLS1_k127_2052558_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006303 273.0
TLS1_k127_2052558_5 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007364 263.0
TLS1_k127_2052558_6 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000000000000000000000000000000000000000000004904 237.0
TLS1_k127_2052558_7 nitric oxide dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000001117 237.0
TLS1_k127_2052558_8 - - - - 0.00000000000000000000000000000000000000000000001024 175.0
TLS1_k127_2052558_9 - - - - 0.000000000000000000000000000000000000001892 153.0
TLS1_k127_2067033_0 belongs to the aldehyde dehydrogenase family K00294,K13821 - 1.2.1.88,1.5.5.2 0.0 1222.0
TLS1_k127_2067033_1 Protein involved in outer membrane biogenesis K07290 - - 0.0 1155.0
TLS1_k127_2067033_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 530.0
TLS1_k127_2067033_11 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 520.0
TLS1_k127_2067033_12 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 489.0
TLS1_k127_2067033_13 Multicopper oxidase K00368,K22349 - 1.16.3.3,1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 457.0
TLS1_k127_2067033_14 phosphorelay signal transduction system K02481,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 458.0
TLS1_k127_2067033_15 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 434.0
TLS1_k127_2067033_16 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 432.0
TLS1_k127_2067033_17 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 393.0
TLS1_k127_2067033_18 methyltransferase K16129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 360.0
TLS1_k127_2067033_19 HDOD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 340.0
TLS1_k127_2067033_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 2.111e-289 909.0
TLS1_k127_2067033_20 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001315 282.0
TLS1_k127_2067033_21 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000004046 262.0
TLS1_k127_2067033_22 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000005759 246.0
TLS1_k127_2067033_23 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000005978 242.0
TLS1_k127_2067033_24 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000008069 201.0
TLS1_k127_2067033_25 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.00000000000000000000000000000000000000000000000000000004163 207.0
TLS1_k127_2067033_26 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000002277 195.0
TLS1_k127_2067033_27 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000002261 185.0
TLS1_k127_2067033_28 negative regulation of translational initiation K05554,K14670,K15886 - 2.3.1.235 0.0000000000000000000000000000000000000000000000002735 182.0
TLS1_k127_2067033_29 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000003435 163.0
TLS1_k127_2067033_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 2.481e-251 785.0
TLS1_k127_2067033_30 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000001739 159.0
TLS1_k127_2067033_31 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000000009122 158.0
TLS1_k127_2067033_32 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.0000000000000000000000000000000000000000348 159.0
TLS1_k127_2067033_33 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000000000000000000000000541 157.0
TLS1_k127_2067033_35 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000000000000000000005085 145.0
TLS1_k127_2067033_4 Tetratricopeptide repeat - - - 8.065e-235 732.0
TLS1_k127_2067033_40 - - - - 0.00000000000000003072 94.0
TLS1_k127_2067033_42 DNA-sulfur modification-associated - - - 0.0000002283 63.0
TLS1_k127_2067033_5 Phosphoglycerate kinase K00927 - 2.7.2.3 6.331e-220 686.0
TLS1_k127_2067033_6 Metallopeptidase family M24 K01262 - 3.4.11.9 6.855e-198 622.0
TLS1_k127_2067033_7 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00322,K00382 - 1.6.1.1,1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 606.0
TLS1_k127_2067033_8 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 581.0
TLS1_k127_2067033_9 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 568.0
TLS1_k127_2067423_0 Cytochrome c K00428 - 1.11.1.5 6.702e-251 783.0
TLS1_k127_2067423_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00615,K00616 - 2.2.1.1,2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 419.0
TLS1_k127_2067423_2 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004956 415.0
TLS1_k127_2067423_3 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006222 282.0
TLS1_k127_2067423_4 PFAM Short-chain dehydrogenase reductase SDR K00034 - 1.1.1.47 0.000000000000000000000000000000000000000000002633 164.0
TLS1_k127_2067423_5 Universal stress protein family - - - 0.00000000000000000000000000000000000000000001526 169.0
TLS1_k127_2067423_6 Protein of unknown function (DUF3015) - - - 0.000000000000000000000000000000007247 133.0
TLS1_k127_2067423_7 - - - - 0.0000000000000000002 94.0
TLS1_k127_2067423_8 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.000000000000000007649 89.0
TLS1_k127_2067423_9 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.0000000495 62.0
TLS1_k127_207397_0 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 344.0
TLS1_k127_207397_1 response regulator K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001259 279.0
TLS1_k127_207397_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001771 265.0
TLS1_k127_207397_3 - - - - 0.000000000000000000000000001083 114.0
TLS1_k127_20758_0 DNA ligase K01971 - 6.5.1.1 1.638e-215 696.0
TLS1_k127_2078220_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000008944 89.0
TLS1_k127_2078583_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 495.0
TLS1_k127_2078583_1 OsmC-like protein - - - 0.000000000000000000000007115 102.0
TLS1_k127_2089783_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.069e-253 785.0
TLS1_k127_2089783_1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000001591 237.0
TLS1_k127_2089783_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000002552 220.0
TLS1_k127_2089783_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000000000000000000000000000000004951 177.0
TLS1_k127_2091626_0 Belongs to the DNA photolyase family K01669 - 4.1.99.3 7.408e-229 718.0
TLS1_k127_2091626_1 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 509.0
TLS1_k127_2091626_2 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 452.0
TLS1_k127_2091626_3 sirohydrochlorin cobaltochelatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 291.0
TLS1_k127_2091626_4 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001037 285.0
TLS1_k127_2091626_5 coenzyme binding K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000001129 229.0
TLS1_k127_2091626_6 Protein of unknown function (DUF2878) - - - 0.000000000000000000000000000000000000000000000000001641 188.0
TLS1_k127_2091626_7 - - - - 0.000000000000000000000000000000000000000000000000002504 184.0
TLS1_k127_2091626_8 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000003216 139.0
TLS1_k127_20932_0 COGs COG3387 Glucoamylase and related glycosyl hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008847 556.0
TLS1_k127_20932_1 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 487.0
TLS1_k127_20932_2 Di- and tricarboxylate transporters - - - 0.00000000000000000000000000000000000000000000003763 178.0
TLS1_k127_210851_0 membrane protein (DUF2306) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001106 241.0
TLS1_k127_2115802_0 Protein of unknown function (DUF1207) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003824 290.0
TLS1_k127_2115802_1 Domain of Unknown Function (DUF748) - - - 0.000000000000002181 89.0
TLS1_k127_212620_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1161.0
TLS1_k127_212620_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 8.05e-322 1006.0
TLS1_k127_212620_10 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 401.0
TLS1_k127_212620_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007078 402.0
TLS1_k127_212620_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 394.0
TLS1_k127_212620_13 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00003,K00982,K00990,K06950,K15371 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 391.0
TLS1_k127_212620_14 Major Facilitator Superfamily K02575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 362.0
TLS1_k127_212620_15 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 296.0
TLS1_k127_212620_16 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 289.0
TLS1_k127_212620_17 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005897 282.0
TLS1_k127_212620_18 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000004539 238.0
TLS1_k127_212620_19 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000005234 213.0
TLS1_k127_212620_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.076e-318 980.0
TLS1_k127_212620_20 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000000000000000000000000000000000000000003854 204.0
TLS1_k127_212620_21 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000007198 192.0
TLS1_k127_212620_22 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000000000000000191 174.0
TLS1_k127_212620_23 PFAM O-methyltransferase family 2 - - - 0.0000000000000000000000000000000000000000000002065 181.0
TLS1_k127_212620_25 Transposase IS200 like - - - 0.000000000000000000000000000000000000000000003917 166.0
TLS1_k127_212620_26 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000004171 143.0
TLS1_k127_212620_27 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01923,K01952 - 6.3.2.6,6.3.5.3 0.00000000000000000000000000000000002638 135.0
TLS1_k127_212620_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 3.692e-262 812.0
TLS1_k127_212620_30 Protein of unknown function (DUF2971) - - - 0.0000000000000000000000000002931 122.0
TLS1_k127_212620_31 Helix-turn-helix domain - - - 0.000000000000000000000000007517 114.0
TLS1_k127_212620_33 - - - - 0.0000000000000000000003924 98.0
TLS1_k127_212620_37 - - - - 0.0000000002266 64.0
TLS1_k127_212620_38 Protein of unknown function (DUF2971) - - - 0.0000001146 59.0
TLS1_k127_212620_39 Transposase IS200 like - - - 0.00002812 46.0
TLS1_k127_212620_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.796e-227 711.0
TLS1_k127_212620_5 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 3.24e-215 672.0
TLS1_k127_212620_6 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 2.7.7.42,2.7.7.89 1.48e-199 636.0
TLS1_k127_212620_7 photosynthesis K02453,K02660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 518.0
TLS1_k127_212620_8 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 493.0
TLS1_k127_212620_9 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 434.0
TLS1_k127_2132541_0 B3/4 domain K01890 - 6.1.1.20 4.012e-249 780.0
TLS1_k127_2132541_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type K01889 - 6.1.1.20 8.656e-249 779.0
TLS1_k127_2132541_2 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 326.0
TLS1_k127_2132541_3 Translation initiation factor IF-3, C-terminal domain K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 291.0
TLS1_k127_2132541_4 16S rRNA methyltransferase RsmB/F K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000009951 246.0
TLS1_k127_2132541_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000000000000000002111 193.0
TLS1_k127_2132541_6 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000005069 97.0
TLS1_k127_2132541_7 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000002467 70.0
TLS1_k127_2143372_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003609 267.0
TLS1_k127_2143372_1 UPF0391 membrane protein - - - 0.0000003431 52.0
TLS1_k127_2146180_0 Belongs to the glutathione peroxidase family K00432,K20207 - 1.11.1.22,1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000004241 240.0
TLS1_k127_2146180_1 - - - - 0.0000000000000000000000000004197 117.0
TLS1_k127_214863_0 RHS Repeat - - - 0.0000003854 64.0
TLS1_k127_214863_1 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00006241 52.0
TLS1_k127_2151827_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1389.0
TLS1_k127_2151827_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 574.0
TLS1_k127_2151827_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 428.0
TLS1_k127_2151827_3 deoxyribose-phosphate aldolase activity K01619 - 4.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 345.0
TLS1_k127_2151827_4 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000000000000000001732 174.0
TLS1_k127_2151827_5 phosphopentomutase activity K01839 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 0.00000000000000000000000003479 109.0
TLS1_k127_2151827_6 regulation of DNA repair K03565,K19002 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019899,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496 2.4.1.337 0.00000000000000000000000007537 115.0
TLS1_k127_2152592_0 ABC transporter K06158 - - 3.091e-306 949.0
TLS1_k127_2152592_1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 582.0
TLS1_k127_2152592_2 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000697 458.0
TLS1_k127_2152592_3 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 319.0
TLS1_k127_2152592_4 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005715 321.0
TLS1_k127_2152592_5 Belongs to the HesB IscA family K15724 - - 0.00000000000000000000000000000000000000000000000000000000021 203.0
TLS1_k127_2152592_7 Ferredoxin K04755 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - 0.0000000000000000000000000000000000000000000000003482 179.0
TLS1_k127_2152592_8 synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000000007619 179.0
TLS1_k127_2156716_0 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000001181 173.0
TLS1_k127_2156716_1 Histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000001379 183.0
TLS1_k127_2156716_2 AMP binding K06149 - - 0.00000000000001662 85.0
TLS1_k127_2156716_3 Universal stress protein family - - - 0.0000000000000297 84.0
TLS1_k127_2156716_4 integral membrane protein - - - 0.00000000001644 67.0
TLS1_k127_2166307_0 - - - - 0.000000000000000000000000000000000000003182 148.0
TLS1_k127_2166307_2 - - - - 0.00000000000001812 74.0
TLS1_k127_2166307_4 - - - - 0.000006434 48.0
TLS1_k127_2173034_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0 1010.0
TLS1_k127_2173034_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.581e-242 752.0
TLS1_k127_2173034_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 452.0
TLS1_k127_2173034_3 Belongs to the pseudouridine synthase RsuA family K06178,K06181,K06182 - 5.4.99.20,5.4.99.21,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 384.0
TLS1_k127_2173463_0 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004114 240.0
TLS1_k127_2173463_1 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.000000000000000000000000000000000000000006103 159.0
TLS1_k127_2175989_1 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 356.0
TLS1_k127_2182909_0 Glutathione S-transferase K00799,K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7,2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 529.0
TLS1_k127_2182909_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 433.0
TLS1_k127_2182909_2 Lipoprotein K04754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 350.0
TLS1_k127_2182909_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002227 285.0
TLS1_k127_2182909_4 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004509 261.0
TLS1_k127_2182909_5 response regulator K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001029 250.0
TLS1_k127_2182909_6 silver ion transport K15726 - - 0.00000000000000000000000000000000000000000000000000000001266 201.0
TLS1_k127_2182909_7 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.00000000000003642 84.0
TLS1_k127_2192609_0 Sigma-54 interaction domain K07714 - - 1.487e-244 764.0
TLS1_k127_2192609_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 557.0
TLS1_k127_2192609_2 Two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003412 290.0
TLS1_k127_2192609_3 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000003781 172.0
TLS1_k127_2192609_4 PFAM Transposase, IS204 IS1001 IS1096 IS1165 K07485 - - 0.00000000000003623 74.0
TLS1_k127_2196608_0 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 435.0
TLS1_k127_2196608_1 phosphorelay signal transduction system K02282,K02482,K04757,K20977 - 2.7.11.1,2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003037 277.0
TLS1_k127_2196608_2 PFAM General secretion pathway protein K K02460 - - 0.000000000000000000000000000000000000001089 159.0
TLS1_k127_2196608_3 antisigma factor binding - - - 0.00000000000000000000000000000000001147 138.0
TLS1_k127_2196608_4 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000002959 88.0
TLS1_k127_2196608_5 Histidine kinase K20976 - - 0.000000002 64.0
TLS1_k127_2196608_6 antisigma factor binding K03409,K04749,K07122 - - 0.00001864 51.0
TLS1_k127_2199306_0 membrane protein of uknown function UCP014873 - - - 0.00000000000000000000000000000000000000000007945 167.0
TLS1_k127_2204162_0 DDE superfamily endonuclease K07494 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009771 344.0
TLS1_k127_2204162_1 - - - - 0.00000000000005213 74.0
TLS1_k127_2207722_0 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 291.0
TLS1_k127_2207722_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000009522 185.0
TLS1_k127_2211227_0 PFAM integrase family protein - - - 0.00000000000000001796 84.0
TLS1_k127_2211227_2 Di-haem cytochrome c peroxidase - - - 0.000842 46.0
TLS1_k127_2213264_0 SMART Tetratricopeptide domain protein - - - 0.000000000000000000000341 108.0
TLS1_k127_2213344_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 0.0 1806.0
TLS1_k127_2213344_1 ATP-grasp domain K01905,K22224 - 6.2.1.13 0.0 1183.0
TLS1_k127_2213344_10 AMP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003215 285.0
TLS1_k127_2213344_11 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001163 274.0
TLS1_k127_2213344_12 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005875 256.0
TLS1_k127_2213344_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002594 258.0
TLS1_k127_2213344_14 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000000000000000005615 239.0
TLS1_k127_2213344_16 hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000001222 194.0
TLS1_k127_2213344_17 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12263 - - 0.0000000000000000000000000000000000000817 149.0
TLS1_k127_2213344_18 Cytochrome c K02305,K17223 - - 0.0000000000000000000000000000000001647 138.0
TLS1_k127_2213344_19 - - - - 0.0000000000000000000000000000000002324 134.0
TLS1_k127_2213344_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1011.0
TLS1_k127_2213344_20 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.000000000000000000000000000001645 123.0
TLS1_k127_2213344_21 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000005479 109.0
TLS1_k127_2213344_3 Arsenical pump-driving ATPase K01551 - 3.6.3.16 3.719e-291 902.0
TLS1_k127_2213344_4 DNA-directed DNA polymerase activity K02347,K04477 - - 3.598e-267 833.0
TLS1_k127_2213344_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K11381 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 562.0
TLS1_k127_2213344_6 S-acyltransferase activity K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 531.0
TLS1_k127_2213344_7 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K00162,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 494.0
TLS1_k127_2213344_8 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 459.0
TLS1_k127_2213344_9 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 404.0
TLS1_k127_222163_1 - - - - 0.00000000000005954 71.0
TLS1_k127_22321_0 transposase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 345.0
TLS1_k127_2234961_0 type III restriction protein res subunit K01153 - 3.1.21.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 301.0
TLS1_k127_2234961_1 - - - - 0.00000000000000000000000002767 108.0
TLS1_k127_2235371_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 419.0
TLS1_k127_2235371_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 346.0
TLS1_k127_2235371_2 Ribosomal protein L4/L1 family K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000978 285.0
TLS1_k127_2235371_3 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000007326 155.0
TLS1_k127_2242219_0 General secretion pathway protein F K02455,K02653 - - 0.0000000000000000000000000000000000000000000000003996 181.0
TLS1_k127_2242219_1 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000000000000000155 180.0
TLS1_k127_2242219_2 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins - - - 0.00000000000000000000926 100.0
TLS1_k127_2242219_3 Type II secretion system (T2SS), protein J K02459 - - 0.0000006146 59.0
TLS1_k127_2242219_4 Prokaryotic N-terminal methylation motif K02457 - - 0.000001492 58.0
TLS1_k127_2242219_5 Type IV pilus assembly protein PilM; K02662 - - 0.0002629 53.0
TLS1_k127_2242219_6 type IV pilus modification protein PilV K02458,K02671 - - 0.000776 48.0
TLS1_k127_2251938_0 Phospholipase, patatin family K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 368.0
TLS1_k127_2251938_1 - - - - 0.0000000000007459 69.0
TLS1_k127_2261729_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 332.0
TLS1_k127_2261729_1 nucleotidyltransferase activity K00984,K19279 - 2.7.7.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000002291 267.0
TLS1_k127_2261729_2 TPM domain K06872 - - 0.00000000000432 70.0
TLS1_k127_2276158_0 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 419.0
TLS1_k127_2279733_0 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 478.0
TLS1_k127_2279733_1 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000002318 74.0
TLS1_k127_2280433_0 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002455 290.0
TLS1_k127_2280433_1 self proteolysis - - - 0.000000005855 65.0
TLS1_k127_2283052_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 428.0
TLS1_k127_2296063_0 - - - - 0.000000000000000000000000000000000000000000000000002215 182.0
TLS1_k127_2310049_0 reverse transcriptase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009254 417.0
TLS1_k127_2310490_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K06147,K11085 - - 1.22e-254 797.0
TLS1_k127_2310490_1 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 1.872e-208 663.0
TLS1_k127_2310490_10 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 0.000000000000000000000000000000000000000000000000000000001709 214.0
TLS1_k127_2310490_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.00000000000000000000000000000000000000000000121 171.0
TLS1_k127_2310490_12 Surface antigen K07277 - - 0.0000000000000001843 79.0
TLS1_k127_2310490_2 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003643 496.0
TLS1_k127_2310490_3 Protein of unknown function (DUF1009) K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 412.0
TLS1_k127_2310490_4 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007682 410.0
TLS1_k127_2310490_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 387.0
TLS1_k127_2310490_6 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000004371 274.0
TLS1_k127_2310490_7 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000001508 235.0
TLS1_k127_2310490_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.00000000000000000000000000000000000000000000000000000000003832 213.0
TLS1_k127_2310490_9 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000000000000000000000000004136 209.0
TLS1_k127_2311011_0 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007623 567.0
TLS1_k127_2311011_1 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 452.0
TLS1_k127_2311011_2 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006418 411.0
TLS1_k127_2311011_3 coenzyme binding K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004108 246.0
TLS1_k127_2314012_0 RNA secondary structure unwinding K03724 - - 0.0 1533.0
TLS1_k127_2314012_1 NADH dehydrogenase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 454.0
TLS1_k127_2314012_2 NADH dehydrogenase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 452.0
TLS1_k127_2314012_3 glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 371.0
TLS1_k127_2314012_4 lipid binding K03098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004113 255.0
TLS1_k127_2314012_5 - - - - 0.0000000000000000000000000000005555 129.0
TLS1_k127_2315526_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000000002967 231.0
TLS1_k127_2315526_1 transposition K07497 - - 0.0000000000000000000000000000000000000000003121 162.0
TLS1_k127_2315526_2 transposase activity K07483,K07497 - - 0.0000000000000000000000000000000000000008252 149.0
TLS1_k127_2315526_3 transposition K07497 - - 0.00000000007374 64.0
TLS1_k127_2315526_4 Transposase and inactivated derivatives - - - 0.00008039 50.0
TLS1_k127_2321741_0 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001861 286.0
TLS1_k127_2326572_0 - - - - 0.000000000000000000001012 99.0
TLS1_k127_2326572_1 HicA toxin of bacterial toxin-antitoxin, - - - 0.00002493 50.0
TLS1_k127_2329969_0 DDE superfamily endonuclease K07494 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 568.0
TLS1_k127_2330260_0 Glycine cleavage system P-protein K00281,K00283 - 1.4.4.2 0.0 1514.0
TLS1_k127_2330260_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 9.118e-220 689.0
TLS1_k127_2330260_10 protein conserved in bacteria - - - 0.000000000000000000000001287 104.0
TLS1_k127_2330260_11 Bacterial antitoxin of type II TA system, VapB - - - 0.00000000000000001718 85.0
TLS1_k127_2330260_12 Phage regulatory protein - - - 0.00000000000000009176 82.0
TLS1_k127_2330260_13 Belongs to the 'phage' integrase family - - - 0.00001629 48.0
TLS1_k127_2330260_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 8.256e-213 670.0
TLS1_k127_2330260_3 Class V aminotransferase K04127 - 5.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 456.0
TLS1_k127_2330260_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 390.0
TLS1_k127_2330260_5 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 332.0
TLS1_k127_2330260_6 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 295.0
TLS1_k127_2330260_8 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000000000000000004082 136.0
TLS1_k127_2330260_9 Sel1-like repeats. - - - 0.0000000000000000000000000543 113.0
TLS1_k127_2330627_0 COG0659 Sulfate permease and related transporters (MFS K01673,K03321 - 4.2.1.1 7.049e-266 834.0
TLS1_k127_233640_0 Rhodopirellula transposase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001302 250.0
TLS1_k127_233640_1 transposition K07497 - - 0.000000000000008463 85.0
TLS1_k127_233640_2 - - - - 0.0000000000002038 76.0
TLS1_k127_2342527_0 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001373 259.0
TLS1_k127_2342527_3 HlyD family secretion protein K03585 - - 0.00000000000000000000004112 102.0
TLS1_k127_234982_0 Transposase (IS116 IS110 IS902 family) - - - 0.0000000000000000000000000000000000000000000000000000000000000001469 235.0
TLS1_k127_2352134_0 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 346.0
TLS1_k127_2362980_0 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0 1495.0
TLS1_k127_2362980_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 450.0
TLS1_k127_2362980_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 355.0
TLS1_k127_2362980_3 'glutamate synthase K00528,K03388 - 1.18.1.2,1.19.1.1,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006091 278.0
TLS1_k127_2402871_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 557.0
TLS1_k127_2402871_1 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009685 303.0
TLS1_k127_2402871_2 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000004762 138.0
TLS1_k127_2408406_0 - - - - 0.00000000000000001309 85.0
TLS1_k127_2408406_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000002493 54.0
TLS1_k127_2408406_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000171 44.0
TLS1_k127_240884_0 transposase activity - - - 0.0000000000000000000000000000000000000000000001428 173.0
TLS1_k127_240884_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.00000005025 55.0
TLS1_k127_2415579_0 cell redox homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000576 247.0
TLS1_k127_2415579_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.000000000000003777 75.0
TLS1_k127_2415579_3 Evidence 5 No homology to any previously reported sequences - - - 0.000005069 52.0
TLS1_k127_2427904_0 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000001252 160.0
TLS1_k127_2427904_1 PFAM Abortive infection protein - - - 0.0001623 49.0
TLS1_k127_2440293_0 alcohol dehydrogenase K00060,K07777 - 1.1.1.103,2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005131 587.0
TLS1_k127_2440293_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 578.0
TLS1_k127_2440293_2 YceI-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 288.0
TLS1_k127_2440293_3 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000001094 94.0
TLS1_k127_2440293_4 energy transducer activity K03832 - - 0.0000000002806 71.0
TLS1_k127_2463807_0 silver ion transport K15726 - - 0.0 1175.0
TLS1_k127_2463807_1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - 1.206e-269 847.0
TLS1_k127_2463807_10 Cation transport ATPase (P-type) K01531 - 3.6.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000239 269.0
TLS1_k127_2463807_11 PFAM Formylglycine-generating sulfatase enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000001195 239.0
TLS1_k127_2463807_12 Macro domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001877 225.0
TLS1_k127_2463807_14 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000002702 203.0
TLS1_k127_2463807_15 PFAM Endonuclease exonuclease phosphatase K06896 - 3.1.3.90 0.00000000000000000000000000000000000000000000000000001311 203.0
TLS1_k127_2463807_16 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.000000000000000000000000000000000000008629 149.0
TLS1_k127_2463807_17 translation initiation factor activity K03407,K03646,K04065,K06596,K07277,K12065,K13593 - 2.7.13.3 0.00000000000000000000000000000000000009915 157.0
TLS1_k127_2463807_18 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000005552 143.0
TLS1_k127_2463807_2 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 593.0
TLS1_k127_2463807_20 Macro domain - - - 0.00000000000000000001689 93.0
TLS1_k127_2463807_21 Peptidase dimerisation domain - - - 0.0000000000000000006697 91.0
TLS1_k127_2463807_22 GCN5 family acetyltransferase - - - 0.00005974 51.0
TLS1_k127_2463807_23 mitochondrial gene expression K02935 - - 0.00008354 49.0
TLS1_k127_2463807_3 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 537.0
TLS1_k127_2463807_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 470.0
TLS1_k127_2463807_5 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009071 454.0
TLS1_k127_2463807_6 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006446 384.0
TLS1_k127_2463807_8 ferroxidase activity K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004431 276.0
TLS1_k127_2463807_9 signal-transduction protein containing cAMP-binding and CBS domains K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007015 275.0
TLS1_k127_2481251_0 PFAM Transposase DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 473.0
TLS1_k127_2481251_1 Esterase-like activity of phytase - - - 0.000000003351 58.0
TLS1_k127_2489179_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003984 252.0
TLS1_k127_249000_0 methyltransferase activity K21310 - 2.1.1.334 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 350.0
TLS1_k127_249000_1 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000005621 218.0
TLS1_k127_249000_2 PFAM multicopper oxidase - - - 0.00000000000000000001709 92.0
TLS1_k127_249000_3 Multicopper oxidase K08100 - 1.3.3.5 0.000000926 55.0
TLS1_k127_249000_4 Transposase (IS116 IS110 IS902 family) K07486 - - 0.000002746 49.0
TLS1_k127_2494477_0 cobalamin binding K21089,K21972,K22491 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 450.0
TLS1_k127_2494477_1 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000714 175.0
TLS1_k127_2509472_0 ABC-type multidrug transport system ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 549.0
TLS1_k127_2509472_1 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 376.0
TLS1_k127_2509472_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006173 278.0
TLS1_k127_2509472_3 Transglutaminase-like superfamily K22452 - 2.3.2.13 0.0000000000000000000000000000000005018 137.0
TLS1_k127_252774_0 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 1.285e-269 837.0
TLS1_k127_252774_1 COG0380 Trehalose-6-phosphate synthase K16055 - 2.4.1.15,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 406.0
TLS1_k127_252774_2 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000506 183.0
TLS1_k127_252774_3 response regulator receiver - - - 0.0000000000000000000000000000000000000000000000008325 196.0
TLS1_k127_252774_4 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000006868 78.0
TLS1_k127_254102_0 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000149 158.0
TLS1_k127_254102_1 CAAX amino terminal protease family - - - 0.00000000000000000004817 96.0
TLS1_k127_254102_2 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.000000001974 59.0
TLS1_k127_2552415_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.5e-323 1002.0
TLS1_k127_2552415_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 1.483e-309 976.0
TLS1_k127_2552415_10 belongs to the thioredoxin family K02453,K07280,K20444,K20543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 532.0
TLS1_k127_2552415_11 Flagellar motor switch protein FliM K02416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 468.0
TLS1_k127_2552415_12 FliG middle domain K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 443.0
TLS1_k127_2552415_13 ATPase family associated with various cellular activities (AAA) K10943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 429.0
TLS1_k127_2552415_14 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 427.0
TLS1_k127_2552415_15 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 377.0
TLS1_k127_2552415_16 Flagellar basal body protein FlaE K02390 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 375.0
TLS1_k127_2552415_17 phosphorelay sensor kinase activity K07708,K07710,K10942 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 373.0
TLS1_k127_2552415_18 Sigma-70, region 4 K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 358.0
TLS1_k127_2552415_19 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 363.0
TLS1_k127_2552415_2 The M ring may be actively involved in energy transduction K02409 - - 9.417e-220 692.0
TLS1_k127_2552415_20 Plays a role in the flagellum-specific transport system K02419 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 349.0
TLS1_k127_2552415_21 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 351.0
TLS1_k127_2552415_22 Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 380.0
TLS1_k127_2552415_23 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 334.0
TLS1_k127_2552415_24 Flagellar basal body rod FlgEFG protein C-terminal K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 333.0
TLS1_k127_2552415_25 Cellulose biosynthesis protein BcsQ K04562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 326.0
TLS1_k127_2552415_26 rRNA (adenine-N6,N6-)-dimethyltransferase activity K02528,K20444 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 344.0
TLS1_k127_2552415_27 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003694 319.0
TLS1_k127_2552415_28 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843,K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000403 290.0
TLS1_k127_2552415_29 Belongs to the flagella basal body rod proteins family K02388 - - 0.0000000000000000000000000000000000000000000000000000000000000000001099 233.0
TLS1_k127_2552415_3 DUF based on E. rectale Gene description (DUF3880) K06320 - - 1.526e-218 693.0
TLS1_k127_2552415_30 regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed - - - 0.0000000000000000000000000000000000000000000000000000000000007404 218.0
TLS1_k127_2552415_31 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum K13626 - - 0.0000000000000000000000000000000000000000000000000000000001065 207.0
TLS1_k127_2552415_32 SRP54-type protein, GTPase domain K02404 - - 0.00000000000000000000000000000000000000000000000000002992 204.0
TLS1_k127_2552415_33 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000000000000000000000000000000000004111 177.0
TLS1_k127_2552415_34 bacterial-type flagellum organization K02279,K02386 - - 0.0000000000000000000000000000000000000000000001748 177.0
TLS1_k127_2552415_35 Role in flagellar biosynthesis K02421 - - 0.00000000000000000000000000000000000002978 153.0
TLS1_k127_2552415_36 Type III flagellar switch regulator (C-ring) FliN C-term K02417 - - 0.000000000000000000000000000000000002828 141.0
TLS1_k127_2552415_37 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000000000000000000000000000000002644 141.0
TLS1_k127_2552415_38 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.00000000000000000000000000000001262 135.0
TLS1_k127_2552415_39 PFAM MgtE intracellular K02383 - - 0.0000000000000000000000000000346 126.0
TLS1_k127_2552415_4 phosphorelay signal transduction system K10941 - - 2.191e-210 663.0
TLS1_k127_2552415_40 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563,K13626 - - 0.000000000000000000000000009338 111.0
TLS1_k127_2552415_41 Role in flagellar biosynthesis K02420 - - 0.000000000000000000000000009484 114.0
TLS1_k127_2552415_42 Flagellar hook-basal body complex protein FliE K02408 - - 0.000000000000000000000000049 110.0
TLS1_k127_2552415_43 phosphorelay signal transduction system K10941 - - 0.000000000000000000000002883 115.0
TLS1_k127_2552415_44 DNA integration K14059 - - 0.00000000000000000000001231 108.0
TLS1_k127_2552415_45 bacterial-type flagellum organization K02398 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009892,GO:0010556,GO:0010605,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031324,GO:0031326,GO:0032268,GO:0032269,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.0000000000000000000002996 99.0
TLS1_k127_2552415_46 Flagellar rod assembly protein muramidase FlgJ K02395,K08309 - - 0.0000000000000003628 83.0
TLS1_k127_2552415_47 flagellar K02418,K02419 - - 0.0000000000001712 76.0
TLS1_k127_2552415_49 COG1344 Flagellin and related hook-associated proteins K02397 - - 0.000000000282 73.0
TLS1_k127_2552415_5 Phosphoenolpyruvate phosphomutase - - - 8.425e-197 623.0
TLS1_k127_2552415_50 Belongs to the bacterial flagellin family K02397 GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000345 70.0
TLS1_k127_2552415_51 Methyltransferase type 11 - - - 0.0000001475 63.0
TLS1_k127_2552415_6 ATP synthase alpha/beta family, beta-barrel domain K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 596.0
TLS1_k127_2552415_7 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 583.0
TLS1_k127_2552415_8 transposition - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 559.0
TLS1_k127_2552415_9 Flagellar basal body rod FlgEFG protein C-terminal K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 489.0
TLS1_k127_2556603_0 - - - - 0.000000000000000000000005786 105.0
TLS1_k127_2556603_1 - - - - 0.0002446 53.0
TLS1_k127_2577638_0 MFS_1 like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 607.0
TLS1_k127_2577638_1 phospholipase Carboxylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 510.0
TLS1_k127_2577638_2 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 319.0
TLS1_k127_2577638_4 - - - - 0.00000000000000000000002033 106.0
TLS1_k127_2577638_5 nuclease activity K06218 - - 0.00000000000000003206 83.0
TLS1_k127_2577638_6 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000002378 55.0
TLS1_k127_259636_0 ATPase activity K01990 - - 2.652e-276 865.0
TLS1_k127_259636_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 2.098e-200 633.0
TLS1_k127_259636_2 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 541.0
TLS1_k127_259636_3 HlyD family secretion protein K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 459.0
TLS1_k127_259636_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 451.0
TLS1_k127_259636_5 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 434.0
TLS1_k127_259636_6 response regulator K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000156 236.0
TLS1_k127_259636_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000001486 243.0
TLS1_k127_259636_8 COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.00000003256 57.0
TLS1_k127_2598182_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 1.156e-318 984.0
TLS1_k127_2598182_1 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000009873 184.0
TLS1_k127_2598182_2 Cytochrome c - - - 0.00000000000000000000000000000000000004119 148.0
TLS1_k127_2598182_4 domain protein K20276 - - 0.00001973 54.0
TLS1_k127_2598314_0 PD-(D/E)XK nuclease superfamily - - - 0.0 1076.0
TLS1_k127_2598314_1 exonuclease activity K16899 - 3.6.4.12 4.702e-245 792.0
TLS1_k127_2598314_10 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000001477 72.0
TLS1_k127_2598314_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004138 382.0
TLS1_k127_2598314_3 amino acid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 306.0
TLS1_k127_2598314_4 - K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000003298 253.0
TLS1_k127_2598314_6 Thioredoxin domain - - - 0.00000000000000000000000000000000000000004032 153.0
TLS1_k127_2598314_7 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000000343 154.0
TLS1_k127_2598314_8 gas vesicle protein - - - 0.000000000000001355 80.0
TLS1_k127_2598314_9 - - - - 0.00000000001735 71.0
TLS1_k127_2642871_0 PFAM integrase - - - 0.00000000000000000000000000000000000000000000000000000000000000006854 235.0
TLS1_k127_2642871_1 Transposase - - - 0.00000000000000002487 88.0
TLS1_k127_264945_0 protein phosphatase regulator activity - - - 0.00000000000000000001885 109.0
TLS1_k127_264945_1 double-stranded DNA 3'-5' exodeoxyribonuclease activity - - - 0.0005639 54.0
TLS1_k127_2674703_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 457.0
TLS1_k127_2674703_2 Histidine kinase - - - 0.0001958 47.0
TLS1_k127_2675193_0 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000006277 234.0
TLS1_k127_2675193_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000006708 205.0
TLS1_k127_2675193_2 Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex K11031 - - 0.0000000000000001145 94.0
TLS1_k127_2675193_3 Lamin Tail Domain - - - 0.0000000000008629 81.0
TLS1_k127_2675193_4 Plasmid encoded RepA protein - - - 0.00000001217 62.0
TLS1_k127_2675193_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0001362 52.0
TLS1_k127_268955_0 Carboxylesterase family K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 366.0
TLS1_k127_268955_1 Cyclase dehydrase - - - 0.0000000000000000000000000000000000000000000001762 178.0
TLS1_k127_2724908_1 - - - - 0.0000000000003313 73.0
TLS1_k127_2725814_0 O-Antigen ligase K02847,K13009 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 301.0
TLS1_k127_2725814_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000006945 198.0
TLS1_k127_2725814_2 Glycosyl transferases group 1 - - - 0.000000000000000000169 100.0
TLS1_k127_2737482_0 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 436.0
TLS1_k127_2759199_0 Bacterial low temperature requirement A protein (LtrA) - - - 0.000000000000000000000000000000000000000000000000000000000000000001537 238.0
TLS1_k127_276128_0 Sterile alpha motif. - - - 0.0 1425.0
TLS1_k127_276128_1 ABC1 family K03688 - - 0.0 1018.0
TLS1_k127_276128_10 TrkA-N domain K03455,K10716 - - 0.0000000000000000000000000000000000000000000000000000000004278 206.0
TLS1_k127_276128_11 - - - - 0.00000000000000000000000000000000000000000000000002786 182.0
TLS1_k127_276128_12 Glycine-zipper domain - - - 0.0000000000000000000000000000000000001131 147.0
TLS1_k127_276128_15 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000004903 123.0
TLS1_k127_276128_16 tRNA 3'-trailer cleavage - - - 0.00000000000000000000007265 103.0
TLS1_k127_276128_17 SnoaL-like domain - - - 0.0000000000000000000002997 101.0
TLS1_k127_276128_18 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000000003779 92.0
TLS1_k127_276128_19 Transposase IS116/IS110/IS902 family - GO:0003674,GO:0003824,GO:0004803,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.0000000000000000002418 88.0
TLS1_k127_276128_2 TrkA-N domain K03455,K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 438.0
TLS1_k127_276128_21 DJ-1/PfpI family - - - 0.00000000000007685 77.0
TLS1_k127_276128_3 epimerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 430.0
TLS1_k127_276128_4 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 391.0
TLS1_k127_276128_5 glycolate biosynthetic process K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 337.0
TLS1_k127_276128_6 protein disulfide oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001159 268.0
TLS1_k127_276128_7 catechol 2,3-dioxygenase activity K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000141 267.0
TLS1_k127_276128_8 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000004895 256.0
TLS1_k127_2764585_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000001404 192.0
TLS1_k127_2764585_1 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.000000006373 68.0
TLS1_k127_2764585_2 Flavin-binding monooxygenase-like K07222 - - 0.0000003439 52.0
TLS1_k127_2764585_3 - - - - 0.0002826 53.0
TLS1_k127_2770142_0 Ribonuclease H protein - - - 0.000000000000000000000000000000000000000000000000002863 208.0
TLS1_k127_2774888_0 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 417.0
TLS1_k127_2774888_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 366.0
TLS1_k127_2774888_2 metal-dependent membrane protease - - - 0.00000000000000000000002946 110.0
TLS1_k127_2774888_3 CAAX protease self-immunity K07052 - - 0.00000000305 68.0
TLS1_k127_277507_0 SPFH domain-Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 289.0
TLS1_k127_277507_1 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.00000000000004069 74.0
TLS1_k127_2784284_0 DDE superfamily endonuclease - - - 0.00000000000000001705 94.0
TLS1_k127_2799191_0 PFAM Transposase K07485 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 293.0
TLS1_k127_2815026_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 9.974e-276 855.0
TLS1_k127_2837154_0 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000009474 164.0
TLS1_k127_2837154_1 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000002782 152.0
TLS1_k127_2862205_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000004336 239.0
TLS1_k127_2864355_0 - - - - 0.000000000000000000000000000000000000005596 153.0
TLS1_k127_2864355_1 - - - - 0.0000718 50.0
TLS1_k127_2947385_0 transposition, RNA-mediated - - - 0.0000000000000000000000000000001788 133.0
TLS1_k127_2947385_1 to reverse transcriptase - GO:0003674,GO:0003824,GO:0003964,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - 0.00001327 53.0
TLS1_k127_294803_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1349.0
TLS1_k127_294803_1 Belongs to the RtcB family K14415 - 6.5.1.3 1.224e-231 724.0
TLS1_k127_294803_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 463.0
TLS1_k127_294803_3 saccharopine dehydrogenase activity K03340 - 1.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 368.0
TLS1_k127_294803_4 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000002713 197.0
TLS1_k127_294803_5 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000002338 130.0
TLS1_k127_294803_7 Bacterial PH domain - - - 0.000000000000000000000000000003351 134.0
TLS1_k127_294803_8 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000003959 90.0
TLS1_k127_294807_0 radical SAM domain protein K04034 - 1.21.98.3 3.189e-265 823.0
TLS1_k127_294807_1 Transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.00000000000000000000000000000007456 128.0
TLS1_k127_2955899_0 glycosyl transferase family 2 K07011 - - 0.000000000000000000000000000000000000003213 155.0
TLS1_k127_2955899_1 PFAM Glycosyl transferase family 2 K07011 - - 0.000000003282 66.0
TLS1_k127_2955899_2 Polysaccharide biosynthesis protein - - - 0.00000003397 63.0
TLS1_k127_2958723_0 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 4.983e-260 808.0
TLS1_k127_2958723_1 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 593.0
TLS1_k127_2958723_2 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 445.0
TLS1_k127_2958723_3 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.000000000000000000000000000002257 123.0
TLS1_k127_2964619_0 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008232 458.0
TLS1_k127_2964619_1 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 292.0
TLS1_k127_2964619_2 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000001982 95.0
TLS1_k127_2983130_0 Transposase K07485 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000002742 177.0
TLS1_k127_3006258_0 GHKL domain K13598 - 2.7.13.3 0.0 1157.0
TLS1_k127_3006258_1 Conserved carboxylase domain K01960 - 6.4.1.1 0.0 1019.0
TLS1_k127_3006258_10 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00966,K00973,K00992 GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.24,2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 413.0
TLS1_k127_3006258_11 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 404.0
TLS1_k127_3006258_12 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 364.0
TLS1_k127_3006258_13 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004483 356.0
TLS1_k127_3006258_14 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 331.0
TLS1_k127_3006258_15 spore germination - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 330.0
TLS1_k127_3006258_16 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004865 317.0
TLS1_k127_3006258_17 phosphate ion binding K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 308.0
TLS1_k127_3006258_18 thioredoxin peroxidase activity K11065 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 308.0
TLS1_k127_3006258_2 Biotin carboxylase C-terminal domain K01959 - 6.4.1.1 4.197e-266 827.0
TLS1_k127_3006258_22 Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family K00326 GO:0000166,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004128,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0005886,GO:0006091,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016070,GO:0016491,GO:0016651,GO:0016653,GO:0019867,GO:0022900,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0098588,GO:0098805,GO:1901265,GO:1901360,GO:1901363 1.6.2.2 0.00000000000000000000000000000000000000000000001149 180.0
TLS1_k127_3006258_23 response regulator, receiver K03413,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000001277 171.0
TLS1_k127_3006258_26 Domain of unknown function (DUF1844) - - - 0.0000000000000000000000000000000000000005352 151.0
TLS1_k127_3006258_28 Regulatory protein, FmdB family - - - 0.0000000000000000000000174 103.0
TLS1_k127_3006258_3 Bacterial regulatory protein, Fis family K13599 - - 1.258e-234 733.0
TLS1_k127_3006258_30 Small metal-binding protein - - - 0.00000000000000003765 85.0
TLS1_k127_3006258_32 beta-lactamase activity K07126 - - 0.000001442 59.0
TLS1_k127_3006258_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00322,K00382 - 1.6.1.1,1.8.1.4 4.388e-220 691.0
TLS1_k127_3006258_5 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 4.845e-206 653.0
TLS1_k127_3006258_6 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 604.0
TLS1_k127_3006258_7 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 536.0
TLS1_k127_3006258_8 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 497.0
TLS1_k127_3006258_9 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 460.0
TLS1_k127_3012233_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 370.0
TLS1_k127_3012233_1 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.000000000000000000000000000000000001162 140.0
TLS1_k127_302060_0 Homoserine dehydrogenase K00003 - 1.1.1.3 2.207e-197 621.0
TLS1_k127_302060_1 Aminotransferase class I and II K14261 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 499.0
TLS1_k127_302487_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 9.541e-196 624.0
TLS1_k127_302487_1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 415.0
TLS1_k127_302487_2 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 329.0
TLS1_k127_302487_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000315 227.0
TLS1_k127_302487_4 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000003643 198.0
TLS1_k127_302489_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 517.0
TLS1_k127_302489_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000008035 199.0
TLS1_k127_3053598_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000002299 121.0
TLS1_k127_3053598_2 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0000229 48.0
TLS1_k127_3065194_0 mismatched DNA binding K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 560.0
TLS1_k127_3065194_1 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002056 267.0
TLS1_k127_3065400_0 DDE superfamily endonuclease - - - 0.00000000000008787 83.0
TLS1_k127_3066219_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000007779 182.0
TLS1_k127_3067776_0 ATPase associated with various cellular activities, AAA_5 K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 464.0
TLS1_k127_3082188_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K06147,K11085 - - 9.06e-257 802.0
TLS1_k127_3082188_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 1.235e-250 775.0
TLS1_k127_3082188_13 thiamine diphosphate biosynthetic process K03154 - - 0.0000000000000000000000002911 106.0
TLS1_k127_3082188_2 Pyridoxal-phosphate dependent enzyme K01738,K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008537 548.0
TLS1_k127_3082188_3 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 481.0
TLS1_k127_3082188_4 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007042 467.0
TLS1_k127_3082188_5 JAB/MPN domain K21140 - 3.13.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000006603 248.0
TLS1_k127_3082188_7 ThiS family K03636 - - 0.000000000000000000000000000000000000000006501 154.0
TLS1_k127_3082188_8 NIL - - - 0.00000000000000000000000000000000009124 134.0
TLS1_k127_3082188_9 PLD-like domain - - - 0.00000000000000000000000000001002 123.0
TLS1_k127_3083954_0 purine nucleotide biosynthetic process K01812,K02529,K16210 - 5.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 515.0
TLS1_k127_3085295_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003218 271.0
TLS1_k127_3085295_1 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000913 195.0
TLS1_k127_3085295_2 metal cluster binding K06940 - - 0.000000000000000000000000000000000000000000000000000489 192.0
TLS1_k127_3085295_4 regulation of translation K03530 - - 0.0000000000000000000000000000000000000000003157 159.0
TLS1_k127_3085295_5 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000000000000000000000000000000001471 134.0
TLS1_k127_3087852_0 transcriptional regulator, LuxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 464.0
TLS1_k127_3087852_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000001189 138.0
TLS1_k127_30931_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 558.0
TLS1_k127_30931_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000001363 164.0
TLS1_k127_30931_2 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000001042 111.0
TLS1_k127_30931_3 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000004445 106.0
TLS1_k127_30931_5 - - - - 0.00000294 51.0
TLS1_k127_3093813_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1220.0
TLS1_k127_3093813_1 DnaJ C terminal domain K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 460.0
TLS1_k127_3093813_2 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002432 274.0
TLS1_k127_3093813_3 response regulator K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001295 245.0
TLS1_k127_3093813_4 MerR HTH family regulatory protein K18997 - - 0.0000000000000000004468 92.0
TLS1_k127_3093813_5 response regulator K02479,K07684,K07685 - - 0.000000002956 64.0
TLS1_k127_310154_0 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K07052 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 285.0
TLS1_k127_310154_1 ADP-glyceromanno-heptose 6-epimerase activity K00311 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001086 266.0
TLS1_k127_310154_2 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000005634 125.0
TLS1_k127_310154_3 metallopeptidase activity K07404 - 3.1.1.31 0.00000000000000000000005875 112.0
TLS1_k127_310154_4 Putative diguanylate phosphodiesterase - - - 0.000000000000000001402 91.0
TLS1_k127_310154_5 COG4968 Tfp pilus assembly protein PilE K02655 - - 0.0000000434 62.0
TLS1_k127_310154_6 Putative diguanylate phosphodiesterase - - - 0.0000007529 52.0
TLS1_k127_310160_0 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000253 254.0
TLS1_k127_310160_1 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000003186 217.0
TLS1_k127_3101992_0 Type II/IV secretion system protein K02454,K02652 - - 0.0 1103.0
TLS1_k127_3101992_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 2.968e-262 818.0
TLS1_k127_3101992_2 Putative modulator of DNA gyrase K03568 - - 4.165e-246 766.0
TLS1_k127_3101992_3 Putative modulator of DNA gyrase K03592 - - 2.122e-197 624.0
TLS1_k127_3101992_4 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 604.0
TLS1_k127_3101992_5 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 585.0
TLS1_k127_3101992_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 390.0
TLS1_k127_3101992_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000004394 206.0
TLS1_k127_3101992_8 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000006294 205.0
TLS1_k127_3106997_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1080.0
TLS1_k127_3106997_2 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000002889 53.0
TLS1_k127_3114151_0 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000003346 154.0
TLS1_k127_3114151_1 Histidine kinase - - - 0.0000000000000000000000000005502 124.0
TLS1_k127_3114151_2 - - - - 0.0000000005909 65.0
TLS1_k127_3117231_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008917 519.0
TLS1_k127_3118157_0 Transposase zinc-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000002686 230.0
TLS1_k127_3118157_1 PFAM transposase, IS4 family protein - - - 0.000000000000000000000004374 108.0
TLS1_k127_3121570_0 RHS Repeat - - - 0.00000000003608 77.0
TLS1_k127_3122803_0 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 295.0
TLS1_k127_3122803_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002624 278.0
TLS1_k127_3122803_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000001603 101.0
TLS1_k127_3122952_0 Belongs to the TPP enzyme family K00156 - 1.2.5.1 4.521e-247 779.0
TLS1_k127_3122952_1 Vitamin K epoxide reductase family - - - 5.588e-234 747.0
TLS1_k127_3122952_2 membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 361.0
TLS1_k127_3122952_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002474 279.0
TLS1_k127_3122952_4 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007864 258.0
TLS1_k127_3122952_5 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000513 250.0
TLS1_k127_3122952_6 - - - - 0.00000000000000000000000000000000000000000000000000000001725 204.0
TLS1_k127_3122952_7 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000001844 94.0
TLS1_k127_3122952_8 Beta/Gamma crystallin - - - 0.00000000207 63.0
TLS1_k127_3124396_0 membrane - - - 0.0000000865 63.0
TLS1_k127_3125829_0 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000434 143.0
TLS1_k127_3126355_0 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.0 1976.0
TLS1_k127_3126355_1 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 488.0
TLS1_k127_3126355_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002687 272.0
TLS1_k127_3126355_3 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000002933 200.0
TLS1_k127_3126355_4 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000001599 156.0
TLS1_k127_3126355_5 TonB-dependent receptor K02014 - - 0.000000000008715 65.0
TLS1_k127_3142952_0 Predicted membrane protein (DUF2127) - - - 0.00000002291 60.0
TLS1_k127_3142952_1 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.000003036 50.0
TLS1_k127_3173961_0 Tfp pilus assembly protein tip-associated adhesin K02674 - - 1.639e-233 738.0
TLS1_k127_3174504_0 Uncharacterized protein conserved in bacteria (DUF2309) K09822 - - 0.0 1435.0
TLS1_k127_3174504_1 NADH-quinone oxidoreductase K00341,K05577 - 1.6.5.3 2.797e-231 728.0
TLS1_k127_3174504_2 NADH-quinone oxidoreductase K00341,K05577 - 1.6.5.3 3.67e-221 700.0
TLS1_k127_3174504_3 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 310.0
TLS1_k127_3174504_4 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000008491 191.0
TLS1_k127_3174504_5 COG1055 Na H antiporter NhaD and related arsenite permeases - - - 0.000000000000000000000002376 102.0
TLS1_k127_3188392_0 Cytochrome c K12263 - - 6.559e-243 764.0
TLS1_k127_3188392_1 phosphorelay sensor kinase activity K02668,K10942 - 2.7.13.3 9.943e-221 693.0
TLS1_k127_3188392_2 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 311.0
TLS1_k127_3188392_3 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005969 245.0
TLS1_k127_3188392_4 OsmC-like protein K09136 - - 0.000000000000000000000000000000000000000000000000000000000000002534 220.0
TLS1_k127_3188392_5 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE K06039,K07235 - - 0.0000000000000000000000000000000000000000000000000000000000001847 213.0
TLS1_k127_3188392_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000007424 211.0
TLS1_k127_3188392_7 phosphorelay signal transduction system K02481 - - 0.0000000000000000000000000000000000000000000000000000002629 195.0
TLS1_k127_3192165_0 PFAM transposase mutator type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 387.0
TLS1_k127_3192165_1 PFAM transposase mutator type - - - 0.000000000000000000000000000000000000000000000000000000000001614 213.0
TLS1_k127_3192165_2 Integrase core domain K07497 - - 0.00000000000000001581 83.0
TLS1_k127_3192165_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000002508 82.0
TLS1_k127_3201346_0 mechanosensitive ion channel activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 586.0
TLS1_k127_3201346_1 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 412.0
TLS1_k127_3201346_2 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 368.0
TLS1_k127_3201346_3 Ammonium transporter K03320,K06580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 331.0
TLS1_k127_3201346_4 thiolester hydrolase activity K06889,K07397 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 315.0
TLS1_k127_3209674_0 PFAM Transposase, IS4-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 548.0
TLS1_k127_3209674_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000001135 201.0
TLS1_k127_3209674_2 Transposase - - - 0.000003296 50.0
TLS1_k127_3209749_0 TonB-dependent receptor K16091 - - 0.0 1164.0
TLS1_k127_3209749_1 thiamine transport K02011 - - 2.709e-221 698.0
TLS1_k127_3209749_10 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000000000000000000002098 171.0
TLS1_k127_3209749_11 DDE superfamily endonuclease K07494 - - 0.000000000000000000000000000000000003223 139.0
TLS1_k127_3209749_12 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000001207 137.0
TLS1_k127_3209749_13 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03832 - - 0.00000000000000000000000000000712 130.0
TLS1_k127_3209749_14 Protein of unknown function (DUF4231) - - - 0.000000000000000000000007628 100.0
TLS1_k127_3209749_15 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000008523 82.0
TLS1_k127_3209749_16 PFAM DNA polymerase beta domain protein region - - - 0.0000000000000135 79.0
TLS1_k127_3209749_17 electron transfer activity K00428 - 1.11.1.5 0.00000008048 57.0
TLS1_k127_3209749_18 - - - - 0.000002436 52.0
TLS1_k127_3209749_2 iron ion homeostasis K02012 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 503.0
TLS1_k127_3209749_3 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005131 512.0
TLS1_k127_3209749_4 ATPase activity K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007604 492.0
TLS1_k127_3209749_5 electron transfer activity K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 389.0
TLS1_k127_3209749_6 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 290.0
TLS1_k127_3209749_7 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001483 269.0
TLS1_k127_3209749_9 bacteriocin transport K03561,K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000286 211.0
TLS1_k127_3211074_0 strictosidine synthase activity - - - 0.0 1601.0
TLS1_k127_3211074_1 ATHILA ORF-1 family - - - 0.0000000001736 74.0
TLS1_k127_3225647_0 DDE_Tnp_1-associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 475.0
TLS1_k127_3225647_1 required for the transposition of insertion element IS2404 - - - 0.00000000000000000000000000000000000005945 152.0
TLS1_k127_3236862_0 Belongs to the 'phage' integrase family - - - 0.00002179 56.0
TLS1_k127_3240869_0 ISXO2-like transposase domain - - - 0.000000000002064 78.0
TLS1_k127_325600_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 1.243e-247 769.0
TLS1_k127_325600_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 1.178e-205 653.0
TLS1_k127_325600_10 belongs to the thioredoxin family K14949,K20543 - 2.7.11.1 0.000000000000000000000000000000000000000000003385 172.0
TLS1_k127_325600_11 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.0000000000000000000000000000000000001131 147.0
TLS1_k127_325600_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000002197 76.0
TLS1_k127_325600_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 454.0
TLS1_k127_325600_3 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 327.0
TLS1_k127_325600_4 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 316.0
TLS1_k127_325600_5 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001381 282.0
TLS1_k127_325600_6 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009541 275.0
TLS1_k127_325600_7 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000001092 202.0
TLS1_k127_325600_8 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000002257 190.0
TLS1_k127_325600_9 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000000000000000000002957 169.0
TLS1_k127_3262687_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.0 1383.0
TLS1_k127_3262687_1 Belongs to the citrate synthase family K01902,K15230,K15233 - 2.3.3.8,6.2.1.5 0.0 1170.0
TLS1_k127_3262687_2 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 2.9e-235 730.0
TLS1_k127_3262687_3 Isocitrate dehydrogenase K00031 - 1.1.1.42 3.538e-201 630.0
TLS1_k127_3262687_4 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 373.0
TLS1_k127_3262687_5 phosphatase - - - 0.000000000000000000000000000000000002364 141.0
TLS1_k127_326333_0 transposase IS116 IS110 IS902 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 561.0
TLS1_k127_326333_1 Endonuclease Exonuclease Phosphatase K01117 - 3.1.4.12 0.0000000000000000000003123 97.0
TLS1_k127_3264776_0 ATP-grasp domain K01905,K22224 - 6.2.1.13 0.0 1150.0
TLS1_k127_3268339_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.0000000000000000000000000000000000000000000000000004 213.0
TLS1_k127_3268599_0 Macro domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 432.0
TLS1_k127_3268599_1 Domain of unknown function (DUF4433) - - - 0.000000000000000000000000000000000000000001746 162.0
TLS1_k127_3268599_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000001114 96.0
TLS1_k127_3268599_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01153 - 3.1.21.3 0.000000002254 57.0
TLS1_k127_3269186_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000758 522.0
TLS1_k127_3269186_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002391 248.0
TLS1_k127_3269969_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 434.0
TLS1_k127_3269969_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 335.0
TLS1_k127_3269969_2 PFAM Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 300.0
TLS1_k127_3269969_3 LmbE homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001085 272.0
TLS1_k127_3269969_4 WbqC-like protein family - - - 0.000000000000000000000000000000000000000000000000000000000000000001053 234.0
TLS1_k127_3272461_0 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000005179 100.0
TLS1_k127_3277049_0 reverse transcriptase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007481 584.0
TLS1_k127_3278269_0 PFAM Integrase catalytic region K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 389.0
TLS1_k127_3278269_1 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000000000000000000001566 169.0
TLS1_k127_3278269_3 Represses a number of genes involved in the response to DNA damage (SOS response) K01356 - 3.4.21.88 0.0000008746 52.0
TLS1_k127_3301798_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 0.0 1126.0
TLS1_k127_3301798_1 Elongation factor G C-terminus K06207 - - 0.0 1047.0
TLS1_k127_3301798_10 - - - - 0.0000000000000000000000000000000000000003898 154.0
TLS1_k127_3301798_11 - - - - 0.000000000000000000000000000000001266 135.0
TLS1_k127_3301798_12 Iron-sulphur cluster assembly - - - 0.00000000000000000000000000000002704 128.0
TLS1_k127_3301798_13 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000000000000000000000000001213 128.0
TLS1_k127_3301798_14 cheY-homologous receiver domain - - - 0.0000000000000000001372 96.0
TLS1_k127_3301798_15 Hpt domain - - - 0.00000000002335 70.0
TLS1_k127_3301798_2 Hsp70 protein K04043,K04044 - - 2.169e-318 983.0
TLS1_k127_3301798_3 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 288.0
TLS1_k127_3301798_4 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 287.0
TLS1_k127_3301798_5 DnaJ molecular chaperone homology domain K04082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000473 282.0
TLS1_k127_3301798_6 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000654 244.0
TLS1_k127_3301798_8 Iron-sulphur cluster biosynthesis K13628 - - 0.000000000000000000000000000000000000000000000000000000000000004958 217.0
TLS1_k127_3301798_9 cell redox homeostasis K03671,K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000008532 199.0
TLS1_k127_3306244_0 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 521.0
TLS1_k127_3306244_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 504.0
TLS1_k127_3306244_2 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0000000000000000000000000000000000000000000006725 167.0
TLS1_k127_3306396_0 xylulokinase activity K00854 - 2.7.1.17 0.0 1017.0
TLS1_k127_3306396_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 563.0
TLS1_k127_3306396_10 - - - - 0.0000000000001835 74.0
TLS1_k127_3306396_11 - - - - 0.0001485 45.0
TLS1_k127_3306396_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000005469 214.0
TLS1_k127_3306396_3 - - - - 0.0000000000000000000000000000000000000001896 153.0
TLS1_k127_3306396_4 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - 0.000000000000000000000000000000000003461 139.0
TLS1_k127_3306396_5 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000000000000000000000000000003204 135.0
TLS1_k127_3306396_6 Protein conserved in bacteria - - - 0.0000000000000000000000000001202 117.0
TLS1_k127_3306396_7 - - - - 0.0000000000000000000309 94.0
TLS1_k127_3306396_8 Protein of unknown function (DUF2442) - - - 0.00000000000000000008989 91.0
TLS1_k127_3306396_9 Protein conserved in bacteria K03654 - 3.6.4.12 0.00000000000001656 77.0
TLS1_k127_331171_0 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009778 398.0
TLS1_k127_331171_1 N-terminal domain of toast_rack, DUF2154 - - - 0.00000000000000000000000000005865 126.0
TLS1_k127_331171_2 - K01992 - - 0.000000000000000000000000161 117.0
TLS1_k127_331171_3 - - - - 0.0000000000000002168 81.0
TLS1_k127_3321276_0 NADH-quinone oxidoreductase K00341 - 1.6.5.3 5.963e-260 808.0
TLS1_k127_3321276_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000003374 106.0
TLS1_k127_3328198_0 L-lysine 6-monooxygenase (NADPH-requiring) K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008867 359.0
TLS1_k127_3328198_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 310.0
TLS1_k127_3328198_10 - - - - 0.0003775 52.0
TLS1_k127_3328198_2 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000001562 222.0
TLS1_k127_3328198_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000001988 189.0
TLS1_k127_3328198_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000001404 153.0
TLS1_k127_3328198_5 PAS domain containing protein - - - 0.000000009501 66.0
TLS1_k127_3328198_6 - - - - 0.000002323 57.0
TLS1_k127_3328198_7 - - - - 0.00002276 56.0
TLS1_k127_3328198_8 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00003431 51.0
TLS1_k127_3328198_9 Protein of unknown function (DUF3887) - - - 0.0002091 50.0
TLS1_k127_332889_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 4.484e-195 630.0
TLS1_k127_332889_1 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.000000002329 60.0
TLS1_k127_3332149_0 Binding-protein-dependent transport system inner membrane component K02037,K02038 - - 8.464e-201 650.0
TLS1_k127_3332149_1 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 455.0
TLS1_k127_3332149_2 Phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 388.0
TLS1_k127_3332149_3 phosphate transport system permease - - - 0.00000000006934 64.0
TLS1_k127_3332336_0 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 387.0
TLS1_k127_3332336_1 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003057 269.0
TLS1_k127_3332336_2 - - - - 0.00001435 52.0
TLS1_k127_3335111_0 to Cytochrome c-554 precursor (C554) (Hydroxylamine oxidoreductase-linked cytochrome) pir A59036 cytochrome c554, tetraheme, precursor - Nitrosomonas europaea - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 297.0
TLS1_k127_3335111_1 PFAM NapC NirT cytochrome c K02569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006324 271.0
TLS1_k127_3335111_2 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003504 261.0
TLS1_k127_3343069_0 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 320.0
TLS1_k127_3352654_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.946e-275 863.0
TLS1_k127_3352654_1 amino acid - - - 8.063e-268 837.0
TLS1_k127_3352654_10 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000002592 147.0
TLS1_k127_3352654_13 Fic/DOC family K07341 - - 0.000000003954 59.0
TLS1_k127_3352654_14 Uncharacterized protein conserved in bacteria (DUF2059) - - - 0.0005209 50.0
TLS1_k127_3352654_16 PFAM Ribbon-helix-helix protein, copG family K21495 - - 0.0008668 42.0
TLS1_k127_3352654_3 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000741 501.0
TLS1_k127_3352654_4 actin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006786 480.0
TLS1_k127_3352654_5 metallopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 415.0
TLS1_k127_3352654_6 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 359.0
TLS1_k127_3352654_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 305.0
TLS1_k127_3352654_8 Evidence 2b Function of strongly homologous gene K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001164 241.0
TLS1_k127_3352654_9 Evidence 2b Function of strongly homologous gene K02003,K09810,K09814 - - 0.0000000000000000000000000000000000000000000000000000000003021 208.0
TLS1_k127_3359572_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.0000000000000000000000000000000000000000006639 170.0
TLS1_k127_3359572_1 Protein of unknown function (DUF3309) - - - 0.00000000001892 65.0
TLS1_k127_3359572_2 Helix-hairpin-helix motif - - - 0.0003006 46.0
TLS1_k127_3363311_0 IMG reference gene - - - 0.000000000000000000000000000000000000000000000624 175.0
TLS1_k127_3363311_1 O-methyltransferase - - - 0.000000000003587 68.0
TLS1_k127_3363311_2 IMG reference gene - - - 0.0006407 49.0
TLS1_k127_3367197_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 550.0
TLS1_k127_3367197_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 541.0
TLS1_k127_3367197_2 CsbD-like - - - 0.0000000000000002842 82.0
TLS1_k127_3378784_0 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 355.0
TLS1_k127_3379572_0 Zinc-binding dehydrogenase K13979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 600.0
TLS1_k127_3383640_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000001258 205.0
TLS1_k127_3383640_1 TPR repeat - - - 0.0000000000000000000000000000000000000000000003095 179.0
TLS1_k127_3385611_0 - - - - 0.00000000000000000000000000000000000000002849 161.0
TLS1_k127_3385611_1 - - - - 0.00000000000000000000001184 102.0
TLS1_k127_3385611_2 chitinase K03791,K17733 - - 0.000000000001108 69.0
TLS1_k127_3414065_0 phosphorelay signal transduction system K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006248 591.0
TLS1_k127_3414065_2 - - - - 0.000000001864 67.0
TLS1_k127_3417985_0 Uncharacterized protein conserved in bacteria (DUF2330) K00347,K21163 GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 8.761e-239 744.0
TLS1_k127_3417985_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 477.0
TLS1_k127_3417985_2 Uncharacterized protein conserved in bacteria (DUF2330) K00347,K21163 GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 0.000000000000000000000000000000000000000000000000000000101 200.0
TLS1_k127_3417985_3 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000102 175.0
TLS1_k127_3417985_4 RNA secondary structure unwinding K03724 - - 0.0000000000000000000000000000000000000001151 153.0
TLS1_k127_3417985_5 Belongs to the NqrB RnfD family - - - 0.00000000000000000000000000001393 126.0
TLS1_k127_3417985_7 - - - - 0.000000000003181 70.0
TLS1_k127_3417985_8 - - - - 0.00001045 57.0
TLS1_k127_3427922_0 receptor-like protein kinase - - - 0.000000000000000000000000000000000000000001009 160.0
TLS1_k127_3427922_1 transposition, RNA-mediated - - - 0.000007943 48.0
TLS1_k127_3430357_0 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000203 165.0
TLS1_k127_3430885_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 571.0
TLS1_k127_3430885_1 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000002037 188.0
TLS1_k127_3441653_0 peptidyl-tyrosine sulfation K02450 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005037 356.0
TLS1_k127_3441653_1 protein tyrosine kinase activity K08252 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 347.0
TLS1_k127_3441653_2 extracellular polysaccharide biosynthetic process K07011,K16706 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001057 279.0
TLS1_k127_345204_0 protein catabolic process K13527 GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369 - 0.0 1017.0
TLS1_k127_345204_1 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K13571 GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 6.3.1.19 2.379e-276 852.0
TLS1_k127_345204_2 O-methyltransferase activity K13571,K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 6.813e-242 758.0
TLS1_k127_345204_3 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 469.0
TLS1_k127_345204_4 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 406.0
TLS1_k127_345204_5 Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine K03432 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 334.0
TLS1_k127_345204_6 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000002794 245.0
TLS1_k127_345204_7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000001556 201.0
TLS1_k127_345204_8 DNA-directed DNA polymerase activity K02347,K03581,K04477 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000002349 192.0
TLS1_k127_345204_9 ThiS family K03154 - - 0.0000000000000000003705 88.0
TLS1_k127_3454025_0 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000007227 189.0
TLS1_k127_3454025_1 - - - - 0.00000000000000000000000000000002357 130.0
TLS1_k127_3465704_0 Transcriptional regulator, Crp Fnr family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002874 262.0
TLS1_k127_3466156_0 sodium:proton antiporter activity K05564,K11105 - - 0.00000000000000000000000000000000000000000000000000000001894 213.0
TLS1_k127_3466156_1 sodium:proton antiporter activity K03316 - - 0.000006727 48.0
TLS1_k127_3471961_0 amine dehydrogenase activity - - - 0.0 1723.0
TLS1_k127_3471961_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.444e-281 871.0
TLS1_k127_3471961_10 L-allo-threonine aldolase activity K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 473.0
TLS1_k127_3471961_11 protein-(glutamine-N5) methyltransferase activity K00543,K16130,K18896,K18897,K21515 - 2.1.1.156,2.1.1.157,2.1.1.209,2.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 407.0
TLS1_k127_3471961_12 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 407.0
TLS1_k127_3471961_13 PHP domain protein K01624,K07053 - 3.1.3.97,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 378.0
TLS1_k127_3471961_14 tRNA (guanine(37)-N(1))-methyltransferase activity K01091,K01633,K15429 - 1.13.11.81,2.1.1.228,3.1.3.18,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 355.0
TLS1_k127_3471961_16 nucleotidyltransferase activity K17882 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 344.0
TLS1_k127_3471961_18 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 310.0
TLS1_k127_3471961_19 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 315.0
TLS1_k127_3471961_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.094e-266 830.0
TLS1_k127_3471961_21 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007203 262.0
TLS1_k127_3471961_22 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000003006 259.0
TLS1_k127_3471961_24 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009733 243.0
TLS1_k127_3471961_25 Cytochrome c mono- and diheme variants - - - 0.0000000000000000000000000000000000000000000000000000000005274 207.0
TLS1_k127_3471961_28 belongs to the thioredoxin family K00384,K03671 - 1.8.1.9 0.00000000000000000000000000000000008571 137.0
TLS1_k127_3471961_29 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000004153 81.0
TLS1_k127_3471961_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 1.001e-217 690.0
TLS1_k127_3471961_30 domain, Protein K18491 - - 0.00000000000000009479 88.0
TLS1_k127_3471961_4 ATP:ADP antiporter activity K03301 - - 5.401e-194 613.0
TLS1_k127_3471961_5 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 621.0
TLS1_k127_3471961_7 amine oxidase K00276 - 1.4.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 571.0
TLS1_k127_3471961_8 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 532.0
TLS1_k127_3471961_9 D-gluconate metabolic process K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000904 521.0
TLS1_k127_3474778_0 - - - - 0.0000000000000002443 83.0
TLS1_k127_3485124_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 501.0
TLS1_k127_3485124_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007022 502.0
TLS1_k127_3485124_10 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000000000000004835 164.0
TLS1_k127_3485124_11 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000002074 103.0
TLS1_k127_3485124_2 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 400.0
TLS1_k127_3485124_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008524 398.0
TLS1_k127_3485124_4 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 344.0
TLS1_k127_3485124_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 284.0
TLS1_k127_3485124_6 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002113 255.0
TLS1_k127_3485124_7 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000005571 226.0
TLS1_k127_3485124_8 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000000000000000002276 199.0
TLS1_k127_3485124_9 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000003564 180.0
TLS1_k127_3488836_0 - - - - 0.0000000000000000007611 94.0
TLS1_k127_3488836_1 - - - - 0.0000000002904 67.0
TLS1_k127_3511451_0 peptidyl-tyrosine sulfation - - - 9.873e-265 831.0
TLS1_k127_3511451_1 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009381 486.0
TLS1_k127_3511451_2 Protein of unknown function (DUF1579) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 313.0
TLS1_k127_3511451_3 Protein of unknown function (DUF4231) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000142 279.0
TLS1_k127_3511451_4 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000001033 178.0
TLS1_k127_3511451_5 TIR domain - - - 0.00000000000000000000000000000000000000000000002884 180.0
TLS1_k127_3560838_0 Diguanylate cyclase - - - 0.0 1170.0
TLS1_k127_3560838_1 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 401.0
TLS1_k127_3560838_2 Bacterial regulatory protein, Fis family K02481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 394.0
TLS1_k127_3560838_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000009638 237.0
TLS1_k127_3560838_4 AcrB/AcrD/AcrF family - - - 0.00000000000000000000000000000000000729 139.0
TLS1_k127_359705_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.106e-203 649.0
TLS1_k127_359705_1 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 536.0
TLS1_k127_359705_2 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006719 425.0
TLS1_k127_359705_3 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 370.0
TLS1_k127_359705_4 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000001766 244.0
TLS1_k127_359705_5 metallocarboxypeptidase activity - - - 0.00000000000000000000000000000000000000000000000004709 187.0
TLS1_k127_359705_6 PFAM Arsenical resistance operon trans-acting repressor ArsD - - - 0.00000000000000000000000000000000000000000000008967 176.0
TLS1_k127_359705_7 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000003537 122.0
TLS1_k127_359705_8 DnaK suppressor protein K06204 - - 0.000000000000000000000000105 109.0
TLS1_k127_3612945_1 DNA restriction-modification system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 295.0
TLS1_k127_3612945_10 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000002481 61.0
TLS1_k127_3612945_11 - - - - 0.00000003111 57.0
TLS1_k127_3612945_2 transposition K07497 - - 0.000000000000000000000000000000000000000000000000000001717 194.0
TLS1_k127_3612945_3 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000004315 151.0
TLS1_k127_3612945_4 DNA repair - - - 0.00000000000000000000000000000000001477 140.0
TLS1_k127_3612945_5 - - - - 0.0000000000000000000000000003319 131.0
TLS1_k127_3612945_6 Sulfurtransferase TusA - - - 0.0000000000000000000000000004236 115.0
TLS1_k127_3612945_7 transposition K07497 - - 0.0000000000000000000005179 100.0
TLS1_k127_3612945_8 DNA polymerase - - - 0.0000000000002612 71.0
TLS1_k127_3612945_9 transposition K07497 - - 0.00000000006855 69.0
TLS1_k127_3617458_0 transport of arsenical compounds across the membrane (export) arsenic resistance by an export mechanism. responsible for the translocation of the substrate across the membrane K03893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 301.0
TLS1_k127_3617458_1 Peptidase M15 K02395 - - 0.00000000000000000000000000000000000000000000000000000004287 205.0
TLS1_k127_3617458_2 phosphorelay signal transduction system K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000002406 190.0
TLS1_k127_3628523_0 Transposase DDE domain group 1 - - - 0.0000000000000000000000000000000291 142.0
TLS1_k127_362999_0 Heparinase II/III N-terminus - - - 9.11e-220 707.0
TLS1_k127_362999_1 undecaprenyl-phosphate glucose phosphotransferase activity K03606,K20997 - - 1.723e-199 631.0
TLS1_k127_362999_2 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 506.0
TLS1_k127_362999_3 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 422.0
TLS1_k127_362999_4 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 368.0
TLS1_k127_362999_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005493 357.0
TLS1_k127_362999_6 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 348.0
TLS1_k127_362999_7 Glycosyl transferase, family 2 K12992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 299.0
TLS1_k127_362999_8 Transport permease protein K09690 - - 0.000000000000000000002895 96.0
TLS1_k127_3637587_0 DNA restriction-modification system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 419.0
TLS1_k127_3637587_1 - - - - 0.000000000000000000000007695 117.0
TLS1_k127_3637587_2 - - - - 0.000000001235 61.0
TLS1_k127_3711784_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 1.67e-206 647.0
TLS1_k127_3716620_0 COGs COG3328 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 441.0
TLS1_k127_3716620_1 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000000000000000000000000000000000000000000000000000000003491 261.0
TLS1_k127_3716620_4 Phage integrase family - - - 0.0001368 47.0
TLS1_k127_3731664_0 - - - - 4.638e-198 633.0
TLS1_k127_3731664_1 - - - - 0.0000000000000001031 85.0
TLS1_k127_3731664_2 - - - - 0.00000000005182 70.0
TLS1_k127_3737048_0 Transposase zinc-binding domain - - - 0.00000000000000000000000000000000000000000000000000000004698 212.0
TLS1_k127_3738212_0 PFAM transposase, mutator type K07493 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003462 552.0
TLS1_k127_3762032_0 hmm pf01609 - - - 0.000000000000000000000000000000000000000000000000000000000000003323 235.0
TLS1_k127_3762032_1 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000000000000000000001736 210.0
TLS1_k127_3772011_0 helix_turn_helix, Lux Regulon K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 620.0
TLS1_k127_3772011_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002271 259.0
TLS1_k127_3772011_2 - - - - 0.00000000000000000000000000003108 123.0
TLS1_k127_3774_0 - - - - 0.000000000000000000000002273 111.0
TLS1_k127_3774_1 - - - - 0.000000000001807 73.0
TLS1_k127_37810_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 7.758e-285 899.0
TLS1_k127_37810_1 Aminotransferase class I and II K10206 - 2.6.1.83 4.954e-242 749.0
TLS1_k127_37810_10 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 462.0
TLS1_k127_37810_11 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 420.0
TLS1_k127_37810_12 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 377.0
TLS1_k127_37810_13 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 366.0
TLS1_k127_37810_14 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 364.0
TLS1_k127_37810_15 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003744 256.0
TLS1_k127_37810_16 Protein conserved in bacteria K16785 - - 0.0000000000000000000000000000000000000000000000001791 183.0
TLS1_k127_37810_17 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000000000000000000000000000000000000001517 155.0
TLS1_k127_37810_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 3.555e-220 687.0
TLS1_k127_37810_20 monooxygenase activity K00688,K15760,K16157,K16242,K18223,K22353,K22357 GO:0003674,GO:0003824,GO:0004497,GO:0005575,GO:0008150,GO:0008152,GO:0009987,GO:0015049,GO:0015050,GO:0015947,GO:0016491,GO:0016705,GO:0016709,GO:0032991,GO:0043446,GO:0044237,GO:0055114,GO:0071704,GO:1902494 1.14.13.227,1.14.13.236,1.14.13.25,1.14.13.69,2.4.1.1 0.000000000001324 72.0
TLS1_k127_37810_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 6.28e-213 667.0
TLS1_k127_37810_4 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 593.0
TLS1_k127_37810_5 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 545.0
TLS1_k127_37810_6 TIGRFAM argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 523.0
TLS1_k127_37810_7 Lysin motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 505.0
TLS1_k127_37810_8 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 461.0
TLS1_k127_37810_9 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 457.0
TLS1_k127_3790690_0 IMG reference gene - - - 0.0000000000000000000000000000000000000000000000000000009509 203.0
TLS1_k127_3790690_1 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000001063 173.0
TLS1_k127_3794463_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 527.0
TLS1_k127_3794463_1 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.000000000001081 72.0
TLS1_k127_3828035_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K06147,K11085 - - 1.981e-269 839.0
TLS1_k127_3828035_1 FAD binding domain K00278 - 1.4.3.16 6.498e-254 793.0
TLS1_k127_3828035_10 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 371.0
TLS1_k127_3828035_11 tRNA processing K06864,K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 366.0
TLS1_k127_3828035_12 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01665 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 364.0
TLS1_k127_3828035_13 Transcriptional regulatory protein, C terminal K07658 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 325.0
TLS1_k127_3828035_14 phosphatase K07093 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008054 317.0
TLS1_k127_3828035_15 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 291.0
TLS1_k127_3828035_16 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002309 280.0
TLS1_k127_3828035_17 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002689 252.0
TLS1_k127_3828035_2 Endoribonuclease that initiates mRNA decay K18682 - - 2.042e-253 793.0
TLS1_k127_3828035_20 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000000000000000001965 134.0
TLS1_k127_3828035_21 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000001519 127.0
TLS1_k127_3828035_22 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0000000000000000000000000001126 117.0
TLS1_k127_3828035_23 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.00000000000000000000000001103 112.0
TLS1_k127_3828035_3 Transglycosylase SLT domain K08309 - - 6.406e-231 738.0
TLS1_k127_3828035_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 1.827e-217 683.0
TLS1_k127_3828035_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 2.895e-209 659.0
TLS1_k127_3828035_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 459.0
TLS1_k127_3828035_7 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006403 427.0
TLS1_k127_3828035_8 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005792 428.0
TLS1_k127_3828035_9 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826,K02619 - 2.6.1.42,4.1.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 400.0
TLS1_k127_383014_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1190.0
TLS1_k127_383014_1 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 0.0 1110.0
TLS1_k127_383014_10 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 383.0
TLS1_k127_383014_11 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006035 369.0
TLS1_k127_383014_13 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000009147 224.0
TLS1_k127_383014_2 Integrase core domain - - - 8.875e-246 763.0
TLS1_k127_383014_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 2.034e-227 714.0
TLS1_k127_383014_4 Evidence 4 Homologs of previously reported genes of - - - 4.242e-225 705.0
TLS1_k127_383014_5 spermidine synthase activity K00797 - 2.5.1.16 4.16e-217 685.0
TLS1_k127_383014_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 594.0
TLS1_k127_383014_7 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 492.0
TLS1_k127_383014_8 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 420.0
TLS1_k127_383014_9 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 398.0
TLS1_k127_3830567_0 Glycosyl hydrolase family 57 - - - 7.079e-320 993.0
TLS1_k127_3830567_1 phosphorelay signal transduction system - - - 1.947e-206 651.0
TLS1_k127_3830567_13 - - - - 0.00004144 52.0
TLS1_k127_3830567_2 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 587.0
TLS1_k127_3830567_3 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 570.0
TLS1_k127_3830567_4 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008706 491.0
TLS1_k127_3830567_5 Polynucleotide adenylyltransferase K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 462.0
TLS1_k127_3830567_6 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005135 361.0
TLS1_k127_3830567_7 Polyprenyl synthetase K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004349 290.0
TLS1_k127_3830567_8 - - - - 0.0000000000000000000000000007772 117.0
TLS1_k127_3830567_9 thiamine diphosphate biosynthetic process K03154 - - 0.000000000000000000000001583 106.0
TLS1_k127_3857942_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.959e-197 624.0
TLS1_k127_3857942_1 hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000000000000000004339 212.0
TLS1_k127_3857942_2 Ribosomal protein L7/L12 C-terminal domain - - - 0.00005419 51.0
TLS1_k127_385848_0 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 587.0
TLS1_k127_385848_1 arylsulfatase A K01130 - 3.1.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006502 560.0
TLS1_k127_385848_2 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000005794 53.0
TLS1_k127_3861268_0 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 0.000000000000000000000000000001786 133.0
TLS1_k127_3895765_0 AMP-binding enzyme - - - 1.082e-298 942.0
TLS1_k127_3897703_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 1.429e-204 643.0
TLS1_k127_39161_0 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000396 92.0
TLS1_k127_39161_1 Peptidase S24-like K13280 - 3.4.21.89 0.00006572 54.0
TLS1_k127_3926249_0 PFAM Integrase catalytic region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000987 456.0
TLS1_k127_3926249_1 PFAM Transposase IS3 IS911 - - - 0.00000000000000000000000000000000000000000002045 166.0
TLS1_k127_3926249_2 Domain of Unknown Function (DUF1259) - - - 0.000000000000000000000000000000009082 127.0
TLS1_k127_3926249_3 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.0002688 44.0
TLS1_k127_39372_0 Surface antigen K07277 - - 6.933e-218 685.0
TLS1_k127_4013693_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000001743 227.0
TLS1_k127_4016598_0 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006175 417.0
TLS1_k127_403873_0 silver ion transport K15726 - - 0.0 1342.0
TLS1_k127_403873_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07798,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 401.0
TLS1_k127_403873_2 Domain of unknown function DUF21 K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 353.0
TLS1_k127_403873_3 - - - - 0.00000000000000000000000000001808 127.0
TLS1_k127_403873_4 - - - - 0.000000000000000000000009618 102.0
TLS1_k127_4040303_0 Lipocalin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 417.0
TLS1_k127_4040303_1 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005273 254.0
TLS1_k127_4047553_0 hydrogen-translocating pyrophosphatase activity K15987 - 3.6.1.1 0.0 1169.0
TLS1_k127_4047553_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0 1146.0
TLS1_k127_4047553_10 thiosulfate sulfurtransferase activity K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 453.0
TLS1_k127_4047553_11 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 358.0
TLS1_k127_4047553_12 NADPH-dependent FMN reductase K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000126 262.0
TLS1_k127_4047553_14 HemY protein K02498 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000001651 178.0
TLS1_k127_4047553_15 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000001457 179.0
TLS1_k127_4047553_16 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000009838 171.0
TLS1_k127_4047553_18 Putative addiction module component - - - 0.0000000000000000000000000000000007746 132.0
TLS1_k127_4047553_2 metalloendopeptidase activity K08602 - - 4.306e-267 839.0
TLS1_k127_4047553_22 2 iron, 2 sulfur cluster binding K02192 GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - 0.00000000000000001377 83.0
TLS1_k127_4047553_23 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000008308 82.0
TLS1_k127_4047553_24 - - - - 0.000000000000004266 77.0
TLS1_k127_4047553_25 Plasmid stabilization system K19092 - - 0.0000000001826 66.0
TLS1_k127_4047553_26 Small metal-binding protein - - - 0.000000007297 66.0
TLS1_k127_4047553_3 NHL repeat - - - 5.225e-239 742.0
TLS1_k127_4047553_4 DHH family K07462 - - 3.545e-233 736.0
TLS1_k127_4047553_5 denitrification pathway - - - 5.85e-220 687.0
TLS1_k127_4047553_6 denitrification pathway - - - 3.232e-199 630.0
TLS1_k127_4047553_7 denitrification pathway - - - 3.655e-196 620.0
TLS1_k127_4047553_8 Histone deacetylase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 517.0
TLS1_k127_4047553_9 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 465.0
TLS1_k127_4047675_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 452.0
TLS1_k127_4047675_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 437.0
TLS1_k127_4047675_2 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004681 421.0
TLS1_k127_4047675_3 silver ion transport K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006678 246.0
TLS1_k127_4047675_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218,K03437,K03501 - 2.1.1.170,2.1.1.185 0.000000000000000000000000000000000000000000000000000000237 205.0
TLS1_k127_4047675_5 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000000009893 159.0
TLS1_k127_4051833_0 transferase activity, transferring hexosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 391.0
TLS1_k127_4051833_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000001835 173.0
TLS1_k127_4051833_2 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000001896 160.0
TLS1_k127_4051833_4 Lipid A 3-O-deacylase (PagL) - - - 0.000000000000002385 83.0
TLS1_k127_4051833_5 methyltransferase - - - 0.000000001101 68.0
TLS1_k127_4051833_6 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000001075 57.0
TLS1_k127_4052458_0 Cytochrome c K12263 - - 0.00000000000002697 79.0
TLS1_k127_4052458_1 hydrogenase expression formation protein HypE K04655 - - 0.00000004283 54.0
TLS1_k127_4055239_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 1.147e-224 703.0
TLS1_k127_4055239_1 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 343.0
TLS1_k127_4055239_2 dead DEAH box helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008017 318.0
TLS1_k127_4055239_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001307 275.0
TLS1_k127_4060456_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 408.0
TLS1_k127_4061747_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.0000000000000000000000000000006163 122.0
TLS1_k127_4061747_1 - - - - 0.0000007992 60.0
TLS1_k127_406209_0 SCO1/SenC - - - 0.0000000000000000000000000000000000000000000000000000000105 205.0
TLS1_k127_406209_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000006077 186.0
TLS1_k127_406209_2 Bilirubin oxidase - - - 0.00000000000001481 74.0
TLS1_k127_4064126_0 glycoside hydrolase K01193 - 3.2.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 548.0
TLS1_k127_4072370_0 peptidase - - - 0.000000000000122 77.0
TLS1_k127_4082750_0 COG3385 FOG Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 428.0
TLS1_k127_4082750_1 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 293.0
TLS1_k127_4082750_2 PFAM Transposase DDE domain - - - 0.00000000000000000000000000000000000000001146 157.0
TLS1_k127_4082750_3 Transposase IS200 like - - - 0.00000000000000000000000000000000000001202 148.0
TLS1_k127_4082750_4 Integrase core domain - - - 0.0000000000000000000000000000001284 135.0
TLS1_k127_4082750_5 transposase activity - - - 0.000000000000000000000000000000262 124.0
TLS1_k127_4082750_6 Transposase DDE domain - - - 0.00000000001017 64.0
TLS1_k127_4082750_7 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.0000000000657 63.0
TLS1_k127_4082750_8 Transposase and inactivated derivatives - - - 0.00000001116 60.0
TLS1_k127_4082750_9 Transposase IS200 like - - - 0.0006363 46.0
TLS1_k127_4084883_0 - - - - 0.00000000000000000001181 97.0
TLS1_k127_4084883_1 Transposase K07483 - - 0.0000000000000003087 82.0
TLS1_k127_4084883_3 Protein of unknown function (DUF3024) - - - 0.00000000008326 66.0
TLS1_k127_4084883_4 PFAM Integrase catalytic region K07497 - - 0.00002471 48.0
TLS1_k127_4084883_5 - - - - 0.00002514 51.0
TLS1_k127_4088409_0 Group II intron maturase-specific domain protein K00986 - 2.7.7.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 497.0
TLS1_k127_4088409_1 Phage derived protein Gp49-like (DUF891) - - - 0.000000000000000000000000000001802 123.0
TLS1_k127_4088409_2 Helix-turn-helix domain - - - 0.000000000000000000002146 97.0
TLS1_k127_4088409_3 - - - - 0.0000001011 60.0
TLS1_k127_4089578_0 His Kinase A (phosphoacceptor) domain K07709 - 2.7.13.3 0.00000000000000000000000000000000000000002173 168.0
TLS1_k127_4089578_1 Transcriptional regulatory protein, C terminal - - - 0.00000001144 58.0
TLS1_k127_4089753_0 Transposase K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 379.0
TLS1_k127_4092543_0 Cytochrome c-type biogenesis protein CcmF K02198 - - 6.271e-310 960.0
TLS1_k127_4092543_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 361.0
TLS1_k127_4092543_10 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.000000004646 61.0
TLS1_k127_4092543_11 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0001254 46.0
TLS1_k127_4092543_12 OmpA family - - - 0.0002198 49.0
TLS1_k127_4092543_2 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004515 280.0
TLS1_k127_4092543_3 oxidoreductase DsbE K02199 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007523 243.0
TLS1_k127_4092543_4 TIGRFAM cytochrome c-type biogenesis protein CcmI K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000008039 252.0
TLS1_k127_4092543_5 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000000000000000007433 207.0
TLS1_k127_4092543_6 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000457 202.0
TLS1_k127_4092543_7 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000000000000000000001597 171.0
TLS1_k127_4092543_8 membrane - - - 0.00000000000000000000000000000000000000001218 159.0
TLS1_k127_4092543_9 anaerobic respiration K10535 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015975,GO:0015980,GO:0016491,GO:0016661,GO:0016663,GO:0019329,GO:0019331,GO:0034641,GO:0042597,GO:0044237,GO:0044281,GO:0044464,GO:0045333,GO:0047991,GO:0055114 1.7.2.6 0.0000000000000000000000000000000005513 134.0
TLS1_k127_4093406_0 - - - - 0.00000000000000000000000000000008766 124.0
TLS1_k127_4093406_3 - - - - 0.000000005419 57.0
TLS1_k127_4093406_4 COG NOG38524 non supervised orthologous group - - - 0.00000004304 55.0
TLS1_k127_4093406_7 - - - - 0.000001989 50.0
TLS1_k127_4106401_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 1.554e-275 856.0
TLS1_k127_4106401_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 581.0
TLS1_k127_4106401_2 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 552.0
TLS1_k127_4106401_3 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 410.0
TLS1_k127_4106401_4 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 348.0
TLS1_k127_4108770_0 von Willebrand factor (vWF) type A domain K02448 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 479.0
TLS1_k127_4113636_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.385e-303 933.0
TLS1_k127_4113636_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.462e-302 928.0
TLS1_k127_4113636_10 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 442.0
TLS1_k127_4113636_11 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 440.0
TLS1_k127_4113636_12 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 433.0
TLS1_k127_4113636_13 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008365 439.0
TLS1_k127_4113636_14 dimethylargininase activity K00819 GO:0003674,GO:0003824,GO:0016403,GO:0016787,GO:0016810,GO:0016813 2.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 433.0
TLS1_k127_4113636_15 AAA domain, putative AbiEii toxin, Type IV TA system K09817,K09820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 423.0
TLS1_k127_4113636_16 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 409.0
TLS1_k127_4113636_17 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009912 404.0
TLS1_k127_4113636_18 pectinesterase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 380.0
TLS1_k127_4113636_19 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 366.0
TLS1_k127_4113636_2 PFAM LOR SDH bifunctional enzyme conserved region - - - 3.327e-195 617.0
TLS1_k127_4113636_20 tRNA 3'-trailer cleavage - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 364.0
TLS1_k127_4113636_21 Zinc-uptake complex component A periplasmic K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 344.0
TLS1_k127_4113636_22 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 340.0
TLS1_k127_4113636_23 Histidine kinase K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 319.0
TLS1_k127_4113636_24 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000001724 272.0
TLS1_k127_4113636_25 domain protein K02004,K06994 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003582 270.0
TLS1_k127_4113636_26 deoxyhypusine monooxygenase activity K02632 - 4.4.1.31 0.0000000000000000000000000000000000000000000000000000000000000000001832 235.0
TLS1_k127_4113636_27 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000000008602 217.0
TLS1_k127_4113636_28 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000000000000000000001689 216.0
TLS1_k127_4113636_29 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000001566 194.0
TLS1_k127_4113636_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 530.0
TLS1_k127_4113636_30 protein trimerization - - - 0.0000000000000000000000000000000000000000000000000001408 190.0
TLS1_k127_4113636_31 chlorophyll binding K02487,K12543 - - 0.0000000000000000000000000000000000000000000000000002464 192.0
TLS1_k127_4113636_35 - K07275 - - 0.00000000000000000000000000001539 126.0
TLS1_k127_4113636_38 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000000000003157 87.0
TLS1_k127_4113636_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 497.0
TLS1_k127_4113636_40 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K10936,K16079 - - 0.000000003432 67.0
TLS1_k127_4113636_5 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 475.0
TLS1_k127_4113636_6 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 468.0
TLS1_k127_4113636_7 pseudouridine synthase activity K06176 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 462.0
TLS1_k127_4113636_8 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 457.0
TLS1_k127_4113636_9 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 451.0
TLS1_k127_4115616_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.0000000002135 68.0
TLS1_k127_4115616_1 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000158 45.0
TLS1_k127_4121225_0 Competence-damaged protein K03742,K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005272 506.0
TLS1_k127_4121225_1 peroxidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 437.0
TLS1_k127_4121225_2 NADH flavin oxidoreductase NADH oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 441.0
TLS1_k127_4121225_4 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 308.0
TLS1_k127_4121225_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000000000001665 219.0
TLS1_k127_4121225_9 ankyrin 3, node of Ranvier (ankyrin G) - - - 0.00000000000000000002168 97.0
TLS1_k127_4129594_0 Protein of unknown function (DUF2971) - - - 0.00000000000000000000000000000000000000004259 162.0
TLS1_k127_4130489_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 415.0
TLS1_k127_4130489_1 membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000002424 186.0
TLS1_k127_4142155_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 383.0
TLS1_k127_4142155_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000324 239.0
TLS1_k127_4142155_2 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000001298 240.0
TLS1_k127_4142155_3 membrane protein (DUF2306) - - - 0.000000000000000000000000000000000000000000000000000000000000000004324 233.0
TLS1_k127_4142155_4 Protein of unknown function (DUF2938) - - - 0.00000000000000000000000000000000000000000000000000000000737 202.0
TLS1_k127_4142155_5 - - - - 0.00000000000000000000000000000000000000000006333 169.0
TLS1_k127_4142155_6 - - - - 0.000000000000000000000001583 106.0
TLS1_k127_4142698_0 PFAM short chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 316.0
TLS1_k127_4142698_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00007821 51.0
TLS1_k127_4143577_0 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000003033 223.0
TLS1_k127_4143577_1 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000002624 168.0
TLS1_k127_4145515_0 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 391.0
TLS1_k127_4145515_1 cellulase activity K12567 - 2.7.11.1 0.000000002097 70.0
TLS1_k127_4147742_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000874 220.0
TLS1_k127_4147742_1 short chain amide porin - - - 0.000000048 55.0
TLS1_k127_4147742_2 - - - - 0.00003749 48.0
TLS1_k127_4152958_0 Histidine kinase K07638 - 2.7.13.3 2.624e-312 976.0
TLS1_k127_4152958_1 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 1.006e-267 844.0
TLS1_k127_4152958_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K20974 - 2.7.13.3 0.0000000000000000000000000004883 119.0
TLS1_k127_4152958_11 heme binding K00463 - 1.13.11.52 0.000000000000000000000000002816 111.0
TLS1_k127_4152958_12 Belongs to the BolA IbaG family K05527,K22066 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019538,GO:0022603,GO:0022604,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051604,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097428,GO:0097659,GO:0106035,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.00000000000000000000000001732 111.0
TLS1_k127_4152958_13 phosphorelay signal transduction system K02535 - 3.5.1.108 0.000000000000000000004511 94.0
TLS1_k127_4152958_14 ATP-binding region, ATPase domain protein domain protein - - - 0.00000000000000003176 85.0
TLS1_k127_4152958_16 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.000000001422 62.0
TLS1_k127_4152958_17 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000002573 64.0
TLS1_k127_4152958_18 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000272 47.0
TLS1_k127_4152958_2 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 5.031e-207 653.0
TLS1_k127_4152958_3 Histidine kinase K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 424.0
TLS1_k127_4152958_4 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 388.0
TLS1_k127_4152958_5 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 302.0
TLS1_k127_4152958_6 Histidine kinase K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001004 262.0
TLS1_k127_4152958_7 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003373 250.0
TLS1_k127_4152958_8 protein disulfide oxidoreductase activity K07390 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - 0.00000000000000000000000000000000000000000000000000000000102 201.0
TLS1_k127_4152958_9 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000000000000003571 199.0
TLS1_k127_4155388_0 Serine dehydrogenase proteinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003141 246.0
TLS1_k127_4155388_1 PFAM type II secretion system protein E K02669 - - 0.00000000000000000000003739 100.0
TLS1_k127_4156392_0 Domain of unknown function (DUF1929) - - - 0.0 1855.0
TLS1_k127_4156392_1 N-Acetylmuramoyl-L-alanine amidase K01207,K01447,K11066,K21574 - 3.2.1.3,3.2.1.52,3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000002781 263.0
TLS1_k127_4156392_2 Protein of unknown function (DUF2442) - - - 0.0000000000000000000004105 101.0
TLS1_k127_4156392_3 nuclease - - - 0.0000000000000000000006245 104.0
TLS1_k127_4156392_4 double-stranded DNA 3'-5' exodeoxyribonuclease activity K01142 - 3.1.11.2 0.00000000000000000003903 94.0
TLS1_k127_4156392_5 nuclease - - - 0.00000000000000006098 83.0
TLS1_k127_4156392_6 Belongs to the 'phage' integrase family - - - 0.00000001412 60.0
TLS1_k127_4157228_0 transposition - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 513.0
TLS1_k127_4157228_1 Sulfatase-modifying factor enzyme 1 - - - 0.000000000005718 66.0
TLS1_k127_4158353_0 Mo-co oxidoreductase dimerisation domain K17225 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000897 479.0
TLS1_k127_4158353_1 Protein of unknown function (DUF3047) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 301.0
TLS1_k127_4158353_2 Cytochrome C oxidase, cbb3-type, subunit III K08738 - - 0.000000000000000000000000000000000000000000000000000000000006462 212.0
TLS1_k127_4158353_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00382 - 1.8.1.4 0.0000000000000000000002196 99.0
TLS1_k127_4158353_4 PFAM Uncharacterised protein family UPF0150 - - - 0.000001012 55.0
TLS1_k127_4158353_5 PFAM Uncharacterised protein family UPF0150 - - - 0.00008185 48.0
TLS1_k127_4158353_6 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.0004585 44.0
TLS1_k127_416274_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 4.922e-211 661.0
TLS1_k127_416274_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 426.0
TLS1_k127_416274_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000007023 139.0
TLS1_k127_4166910_0 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 430.0
TLS1_k127_4166910_1 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 310.0
TLS1_k127_4166910_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000001206 115.0
TLS1_k127_4167579_0 Type ii secretion system protein e K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 561.0
TLS1_k127_4167579_1 Pilus formation protein N terminal region K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 486.0
TLS1_k127_4167579_10 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000007818 200.0
TLS1_k127_4167579_11 AAA domain K02282 - - 0.000000000000000000000000000000000000000000000000004937 196.0
TLS1_k127_4167579_12 PFAM TadE family protein - - - 0.00000000000000000000000000000000000000000000006817 182.0
TLS1_k127_4167579_13 Pilus formation protein N terminal region K02280 - - 0.0000000000000000000000000000000002609 141.0
TLS1_k127_4167579_14 PFAM Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.0000000000000000000000000884 113.0
TLS1_k127_4167579_15 PFAM TadE family protein - - - 0.00000000000000000000003572 104.0
TLS1_k127_4167579_16 phosphorelay signal transduction system K02535 - 3.5.1.108 0.0000000000000000001734 89.0
TLS1_k127_4167579_17 Transposase - - - 0.000000000000203 76.0
TLS1_k127_4167579_2 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 416.0
TLS1_k127_4167579_20 Flp/Fap pilin component K02651 - - 0.00000174 51.0
TLS1_k127_4167579_3 PFAM Glycosyl transferase family 2 K00694 - 2.4.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006617 386.0
TLS1_k127_4167579_4 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 354.0
TLS1_k127_4167579_5 PFAM Prenyltransferase squalene oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001346 278.0
TLS1_k127_4167579_6 Type ii secretion system K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000001321 235.0
TLS1_k127_4167579_7 PFAM type II secretion system K12511 - - 0.00000000000000000000000000000000000000000000000000000000000001683 226.0
TLS1_k127_4167579_8 Flp pilus assembly protein CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000004609 208.0
TLS1_k127_4167579_9 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000002714 204.0
TLS1_k127_4173930_0 amino acid - - - 6.301e-238 743.0
TLS1_k127_4173930_1 Arginase family K01480 - 3.5.3.11 1.739e-212 663.0
TLS1_k127_4173930_2 - K18829 - - 0.0007442 43.0
TLS1_k127_4176366_0 radical SAM domain protein - - - 1.879e-273 859.0
TLS1_k127_4176366_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 377.0
TLS1_k127_4176366_2 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006562 276.0
TLS1_k127_4176366_3 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001246 253.0
TLS1_k127_4176366_4 protein disulfide oxidoreductase activity K03673 - - 0.000000000000000000000000000000000000000000000000003146 187.0
TLS1_k127_4176366_6 short chain amide porin - - - 0.000000000000000000000000007136 111.0
TLS1_k127_4176366_7 Histidine Phosphotransfer domain K05962 - 2.7.13.1 0.0000000000000000000008936 106.0
TLS1_k127_4176366_8 Flagellar basal body rod FlgEFG protein C-terminal K02388 - - 0.000000000000000000003788 97.0
TLS1_k127_4181572_0 PFAM Di-trans-poly-cis-decaprenylcistransferase-like K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 373.0
TLS1_k127_4181572_1 Domain of unknown function (DUF1989) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002411 265.0
TLS1_k127_4181572_2 TIGRFAM Malto-oligosyltrehalose synthase K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000001589 233.0
TLS1_k127_4186501_0 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007149 336.0
TLS1_k127_4186501_1 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000001982 181.0
TLS1_k127_4186501_2 Proton-conducting membrane transporter K12137 - - 0.0000000000000002669 82.0
TLS1_k127_4186501_3 phosphate ion binding K02040 - - 0.0000000004453 61.0
TLS1_k127_4192636_0 transcriptional regulator K03556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 469.0
TLS1_k127_4194396_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008809 396.0
TLS1_k127_4194396_1 addiction module antidote protein - - - 0.0000000000000000000000000001564 117.0
TLS1_k127_4194396_2 addiction module killer protein - - - 0.000000000000000000000000001395 112.0
TLS1_k127_4194396_3 - - - - 0.00000000000001537 78.0
TLS1_k127_4194396_4 addiction module killer protein - - - 0.000000002441 58.0
TLS1_k127_4194396_5 Helix-turn-helix K21498 - - 0.00001336 48.0
TLS1_k127_4198015_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 6.453e-249 770.0
TLS1_k127_4198015_1 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 399.0
TLS1_k127_4198015_2 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002066 259.0
TLS1_k127_4198015_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000009881 218.0
TLS1_k127_4198015_5 integral membrane protein - - - 0.0000000000000000000000000000000005955 136.0
TLS1_k127_4198015_7 PFAM Transposase, IS204 IS1001 IS1096 IS1165 K07485 - - 0.0000000000000000000000003374 106.0
TLS1_k127_4198015_8 antisigma factor binding K03598 - - 0.000000001061 64.0
TLS1_k127_4198015_9 PFAM transposase IS204 IS1001 IS1096 IS1165 family protein K07485 - - 0.000003196 50.0
TLS1_k127_4204912_0 Di-haem cytochrome c peroxidase - - - 1.364e-289 904.0
TLS1_k127_4204912_1 Proteasomal ATPase OB/ID domain K13527 - - 7.025e-274 852.0
TLS1_k127_4204912_10 Proteasome subunit K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 430.0
TLS1_k127_4204912_11 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005647 398.0
TLS1_k127_4204912_12 PFAM metal-dependent phosphohydrolase, HD sub domain K01524,K07012 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 387.0
TLS1_k127_4204912_13 Class ii aldolase K01628,K18847 - 2.2.1.8,4.1.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 377.0
TLS1_k127_4204912_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 361.0
TLS1_k127_4204912_15 Proteasome subunit K03432 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 306.0
TLS1_k127_4204912_16 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000006021 184.0
TLS1_k127_4204912_17 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000002327 173.0
TLS1_k127_4204912_2 Pup-ligase protein K20814 - 3.5.1.119 6.914e-266 825.0
TLS1_k127_4204912_20 May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes - - - 0.000000000000000000002035 94.0
TLS1_k127_4204912_22 cellulase activity K18197 - 4.2.2.23 0.00085 45.0
TLS1_k127_4204912_3 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 2.022e-258 797.0
TLS1_k127_4204912_4 Pup-ligase protein K13571 - 6.3.1.19 1.879e-230 722.0
TLS1_k127_4204912_5 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 587.0
TLS1_k127_4204912_6 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K08070 - 1.3.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006392 531.0
TLS1_k127_4204912_7 Recombinase zinc beta ribbon domain K06400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 530.0
TLS1_k127_4204912_8 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 445.0
TLS1_k127_4204912_9 poly(3-hydroxybutyrate) depolymerase activity K07019 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0071704 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 447.0
TLS1_k127_4221838_0 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.000000000000000000000000000000000000000000000005394 174.0
TLS1_k127_4221838_1 Cupin domain - - - 0.0000000000000000000000000000000000000006546 150.0
TLS1_k127_4221838_2 Putative addiction module component - - - 0.000000000000000000000000002013 112.0
TLS1_k127_4224037_0 - - - - 0.00000000000000000000000000000000000006091 146.0
TLS1_k127_4224037_1 - - - - 0.00000000000000000002507 94.0
TLS1_k127_4224037_2 - - - - 0.000000000000003177 76.0
TLS1_k127_4224037_3 - - - - 0.000000000608 61.0
TLS1_k127_4224037_4 - - - - 0.00001872 47.0
TLS1_k127_42267_0 Transposase (IS116 IS110 IS902 family) - - - 0.000000000000000000000000000000000000000000000000000000000001688 223.0
TLS1_k127_4228448_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005833 277.0
TLS1_k127_4228448_1 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000005782 131.0
TLS1_k127_4242069_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1091.0
TLS1_k127_4242069_1 Belongs to the aldehyde dehydrogenase family K00130,K00135,K00146,K22187 - 1.2.1.16,1.2.1.20,1.2.1.39,1.2.1.79,1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 367.0
TLS1_k127_4242069_2 Lipid A 3-O-deacylase (PagL) - - - 0.00000000001205 72.0
TLS1_k127_4252068_0 PFAM Response regulator receiver domain - - - 0.0000000000000000000000001553 110.0
TLS1_k127_4252068_1 TRL-like protein family - - - 0.00000000003497 67.0
TLS1_k127_4283804_0 helicase activity - - - 9.527e-290 901.0
TLS1_k127_4283804_1 Uncharacterized protein family, UPF0114 K03535 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005453 287.0
TLS1_k127_4283804_2 histidine kinase response regulator K13587 - 2.7.13.3 0.0007647 44.0
TLS1_k127_4288355_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.271e-210 660.0
TLS1_k127_4288355_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 480.0
TLS1_k127_4288355_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K06142 - - 0.000000000000000000000000000000000000000000000000000000000000000000009657 238.0
TLS1_k127_4288355_3 Rhodanese-like domain - - - 0.000000000000000000000000000000000000000000000000000004425 193.0
TLS1_k127_4295980_0 COG2202 FOG PAS PAC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007957 306.0
TLS1_k127_4295980_1 response regulator K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000001396 236.0
TLS1_k127_4295980_2 Histidine kinase - - - 0.00000000000000000000000000000000000003304 166.0
TLS1_k127_4295980_3 Putative transposase of IS4/5 family (DUF4096) - - - 0.0001071 44.0
TLS1_k127_4306452_0 Domain of unknown function (DUF1929) - - - 0.0 1164.0
TLS1_k127_4306452_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0 1111.0
TLS1_k127_4306452_10 metalloendopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 393.0
TLS1_k127_4306452_11 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 375.0
TLS1_k127_4306452_12 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 368.0
TLS1_k127_4306452_13 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007421 342.0
TLS1_k127_4306452_14 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 331.0
TLS1_k127_4306452_15 RNA-DNA hybrid ribonuclease activity K03471 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 317.0
TLS1_k127_4306452_16 Phosphoribosyl-AMP cyclohydrolase K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 315.0
TLS1_k127_4306452_17 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 310.0
TLS1_k127_4306452_18 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 296.0
TLS1_k127_4306452_19 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001231 286.0
TLS1_k127_4306452_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 6.084e-276 859.0
TLS1_k127_4306452_20 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000132 219.0
TLS1_k127_4306452_22 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000000000000000003609 169.0
TLS1_k127_4306452_23 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000000000000000000000000000000005916 166.0
TLS1_k127_4306452_24 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000662 143.0
TLS1_k127_4306452_25 Protein of unknown function (DUF2905) - - - 0.000000000000000000000009952 102.0
TLS1_k127_4306452_26 DNA polymerase beta domain protein region - - - 0.000000000000000000001685 98.0
TLS1_k127_4306452_27 PFAM RNA-directed DNA polymerase (Reverse transcriptase) K00986 - 2.7.7.49 0.0000000001129 65.0
TLS1_k127_4306452_28 Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000001915 55.0
TLS1_k127_4306452_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 1.595e-223 709.0
TLS1_k127_4306452_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 9.929e-204 636.0
TLS1_k127_4306452_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 602.0
TLS1_k127_4306452_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 586.0
TLS1_k127_4306452_7 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 557.0
TLS1_k127_4306452_8 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 447.0
TLS1_k127_4306452_9 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 421.0
TLS1_k127_4321096_0 PFAM Integrase core domain K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002056 267.0
TLS1_k127_4321096_1 Thioesterase domain - - - 0.00000000000000000000000000000000000003189 153.0
TLS1_k127_4326876_0 COG NOG14600 non supervised orthologous group - - - 0.0000000000000000000000000000000000000000000000002862 178.0
TLS1_k127_4326876_1 COG NOG15344 non supervised orthologous group - - - 0.000000000000004884 78.0
TLS1_k127_4326876_2 - - - - 0.0000000174 56.0
TLS1_k127_4333677_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 565.0
TLS1_k127_4333677_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000008526 83.0
TLS1_k127_4333729_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000000000005257 219.0
TLS1_k127_4337551_0 Carbonic Anhydrase K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000008756 207.0
TLS1_k127_4337551_1 carbonic anhydrase K01674 - 4.2.1.1 0.000000000000000000000000000000000000000000001448 175.0
TLS1_k127_4339233_0 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.00000000000000000000000000000000000000000000000000000006018 200.0
TLS1_k127_4339233_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000008056 206.0
TLS1_k127_4342234_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 297.0
TLS1_k127_4350105_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002802 280.0
TLS1_k127_4350105_2 methyltransferase - - - 0.00000000000000000000000000000000000000000004043 166.0
TLS1_k127_4358320_0 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0000000000000000000000000000000000000000001006 167.0
TLS1_k127_4367298_0 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 393.0
TLS1_k127_4367298_1 Glycosyltransferase family 9 (heptosyltransferase) K02841,K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 357.0
TLS1_k127_4367298_2 ADP-heptose-lipopolysaccharide heptosyltransferase activity K02843 - - 0.00000000000000002528 89.0
TLS1_k127_4367649_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 365.0
TLS1_k127_4370862_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 3.413e-201 633.0
TLS1_k127_4370862_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 586.0
TLS1_k127_4370862_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001361 286.0
TLS1_k127_4370862_3 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000002935 239.0
TLS1_k127_4370862_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000000000000085 208.0
TLS1_k127_4370862_5 Phage integrase family - - - 0.0000000000000000000000002525 114.0
TLS1_k127_4370862_6 Helix-hairpin-helix motif K02237 - - 0.000000000005577 72.0
TLS1_k127_4371677_0 extracellular polysaccharide biosynthetic process K07011,K16706 - - 3.751e-229 722.0
TLS1_k127_4371677_1 Protein conserved in bacteria K20920 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006868 429.0
TLS1_k127_4371677_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01991 - - 0.00000000000000000000000035 105.0
TLS1_k127_4373801_0 metallopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 450.0
TLS1_k127_437564_0 PFAM RNA-directed DNA polymerase (Reverse transcriptase) K00986 - 2.7.7.49 0.000000000000000000000001682 103.0
TLS1_k127_4383375_0 rRNA (guanine-N2-)-methyltransferase activity K13604,K21460 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.304,2.1.1.333 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005347 577.0
TLS1_k127_4383375_1 Transcriptional regulatory protein, C terminal K07658 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 362.0
TLS1_k127_4383375_2 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000001242 267.0
TLS1_k127_4384914_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 2.777e-227 711.0
TLS1_k127_4384914_1 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 280.0
TLS1_k127_4384914_2 Protein of unknown function (DUF3108) - - - 0.0000000000000000004899 93.0
TLS1_k127_4402883_0 Group II intron maturase-specific domain protein K00986 - 2.7.7.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 536.0
TLS1_k127_4402883_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 376.0
TLS1_k127_4402883_2 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000153 169.0
TLS1_k127_4402883_3 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.00000000000000000000000001809 109.0
TLS1_k127_4402883_4 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000003297 96.0
TLS1_k127_4404972_0 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 542.0
TLS1_k127_4404972_1 PFAM type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000008493 169.0
TLS1_k127_4404972_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000001785 133.0
TLS1_k127_4404972_3 - - - - 0.000000000000000000000000003441 112.0
TLS1_k127_4404972_4 Protein of unknown function (DUF2283) - - - 0.0000000000000000000000008919 104.0
TLS1_k127_4404972_5 PFAM type II secretion system protein E K02669 - - 0.000000000000000000000005576 102.0
TLS1_k127_4404972_6 Transcription regulator of the Arc MetJ class - - - 0.000000000000000004777 85.0
TLS1_k127_4404972_7 PFAM type II secretion system protein E K02669 - - 0.00000000000000003302 82.0
TLS1_k127_4415781_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1517.0
TLS1_k127_4415781_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 443.0
TLS1_k127_4415781_3 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000385 121.0
TLS1_k127_4436110_0 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002949 265.0
TLS1_k127_4436110_1 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000000003409 192.0
TLS1_k127_4452146_0 Pfam Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 434.0
TLS1_k127_4452146_1 IMG reference gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009315 337.0
TLS1_k127_4452146_2 SNF2 family N-terminal domain - - - 0.0000000000000003663 81.0
TLS1_k127_4452146_4 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000001848 63.0
TLS1_k127_4454853_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0 1350.0
TLS1_k127_4454853_1 ribosome binding - - - 2.007e-241 780.0
TLS1_k127_4454853_2 ATPase involved in DNA repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 528.0
TLS1_k127_4454853_3 - - - - 0.000000000000000000000000000000000000000000000000004207 186.0
TLS1_k127_4469233_0 - - - - 0.000000000000000000000000000000000000000000738 160.0
TLS1_k127_4469233_1 - - - - 0.00000000000000000007383 90.0
TLS1_k127_4469233_2 - - - - 0.00000000338 64.0
TLS1_k127_4469233_3 - - - - 0.00005724 46.0
TLS1_k127_4469657_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.0 1043.0
TLS1_k127_4469657_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1026.0
TLS1_k127_4469657_10 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 5.044e-204 641.0
TLS1_k127_4469657_11 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 537.0
TLS1_k127_4469657_12 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005601 494.0
TLS1_k127_4469657_13 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 465.0
TLS1_k127_4469657_14 ATP synthase K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 448.0
TLS1_k127_4469657_15 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000905 440.0
TLS1_k127_4469657_16 calcium, potassium:sodium antiporter activity K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 436.0
TLS1_k127_4469657_17 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 385.0
TLS1_k127_4469657_18 Bacterial extracellular solute-binding protein K02027,K10236 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 388.0
TLS1_k127_4469657_19 Glycosyl transferase family 2 K21349 - 2.4.1.268 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 366.0
TLS1_k127_4469657_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 2.627e-313 974.0
TLS1_k127_4469657_20 mannosylglycerate metabolic process K05947,K07026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 307.0
TLS1_k127_4469657_21 Binding-protein-dependent transport system inner membrane component K02025,K10237,K15771 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 308.0
TLS1_k127_4469657_22 Mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 298.0
TLS1_k127_4469657_23 PFAM ABC transporter related K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009712 299.0
TLS1_k127_4469657_24 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009705 289.0
TLS1_k127_4469657_25 Binding-protein-dependent transport system inner membrane component K02026,K10238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004276 272.0
TLS1_k127_4469657_26 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000006374 281.0
TLS1_k127_4469657_27 transmembrane transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000004155 241.0
TLS1_k127_4469657_28 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000003148 172.0
TLS1_k127_4469657_29 mannose-1-phosphate guanylyltransferase activity K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000007202 135.0
TLS1_k127_4469657_3 TIGRFAM Malto-oligosyltrehalose synthase K06044 - 5.4.99.15 2.248e-310 978.0
TLS1_k127_4469657_30 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000194 134.0
TLS1_k127_4469657_31 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000001973 91.0
TLS1_k127_4469657_32 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.000000000000001559 80.0
TLS1_k127_4469657_33 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0000000009374 59.0
TLS1_k127_4469657_35 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000003537 50.0
TLS1_k127_4469657_36 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.000004527 53.0
TLS1_k127_4469657_37 Protein conserved in bacteria - - - 0.00000886 48.0
TLS1_k127_4469657_38 Protein conserved in bacteria - - - 0.000946 44.0
TLS1_k127_4469657_4 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 1.623e-259 810.0
TLS1_k127_4469657_5 Glycosyl hydrolases family 15 - - - 4.776e-242 761.0
TLS1_k127_4469657_6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 4.832e-237 751.0
TLS1_k127_4469657_7 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 7.221e-233 726.0
TLS1_k127_4469657_8 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 2.381e-210 675.0
TLS1_k127_4469657_9 Glycosyl transferase, family 2 K21349 - 2.4.1.268 1.466e-208 656.0
TLS1_k127_4477779_0 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 3.375e-251 785.0
TLS1_k127_4477779_1 Male sterility protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000342 499.0
TLS1_k127_4477779_2 uroporphyrinogen-III synthase activity K01719,K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 345.0
TLS1_k127_4477779_3 Cadherin-like beta sandwich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002447 251.0
TLS1_k127_4477779_4 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000005875 201.0
TLS1_k127_4477779_5 23S rRNA-intervening sequence protein - - - 0.000000000000000000001963 98.0
TLS1_k127_4481129_0 GAF domain - - - 7.399e-301 936.0
TLS1_k127_4481129_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 4.846e-225 705.0
TLS1_k127_4481129_10 Integrase core domain - - - 0.00000000000000000000000000000000258 131.0
TLS1_k127_4481129_11 - - - - 0.000000000000000000000004061 102.0
TLS1_k127_4481129_12 Transposase and inactivated derivatives - - - 0.0000000000001618 79.0
TLS1_k127_4481129_13 - - - - 0.00000000001052 66.0
TLS1_k127_4481129_14 LysR substrate binding domain K03717 - - 0.0000001318 55.0
TLS1_k127_4481129_2 Bacterial regulatory protein, Fis family K07714 - - 5.805e-220 690.0
TLS1_k127_4481129_3 protein secretion by the type I secretion system K02021 - - 5.549e-211 669.0
TLS1_k127_4481129_4 efflux transmembrane transporter activity - - - 1.539e-200 635.0
TLS1_k127_4481129_5 Sulfate permease family - - - 8.215e-197 622.0
TLS1_k127_4481129_6 sulfate reduction K00390,K00957 - 1.8.4.10,1.8.4.8,2.7.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 409.0
TLS1_k127_4481129_8 Transposase K02557,K07484,K13924,K21471 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000009895 153.0
TLS1_k127_4481129_9 Universal stress protein family - - - 0.0000000000000000000000000000000008615 134.0
TLS1_k127_4483307_0 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 330.0
TLS1_k127_4483307_1 2 iron, 2 sulfur cluster binding K13643 - - 0.00000000000000000000000000000000000000000000000000000000000000003994 225.0
TLS1_k127_4486779_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001745 281.0
TLS1_k127_4486779_2 - - - - 0.00000000004843 70.0
TLS1_k127_4490484_0 chaperone-mediated protein folding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 431.0
TLS1_k127_4490484_1 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000001507 157.0
TLS1_k127_4493670_0 transposase IS116 IS110 IS902 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 441.0
TLS1_k127_4534564_0 methyltransferase K16129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 350.0
TLS1_k127_4534564_1 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000000000000133 226.0
TLS1_k127_4534564_2 - K07184,K07777,K12065,K13527 - 2.7.13.3 0.0004082 44.0
TLS1_k127_4538130_0 Cation transporter/ATPase, N-terminus - - - 0.0 1244.0
TLS1_k127_4538130_1 AAA domain - - - 0.0 1229.0
TLS1_k127_4538130_10 AMP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004173 322.0
TLS1_k127_4538130_11 ErfK ybiS ycfS ynhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 306.0
TLS1_k127_4538130_12 thiolester hydrolase activity K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 299.0
TLS1_k127_4538130_13 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000161 273.0
TLS1_k127_4538130_14 regulation of translation K03704,K05809 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002495 256.0
TLS1_k127_4538130_15 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281,K12132 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0018130,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0030145,GO:0034641,GO:0034654,GO:0043094,GO:0043167,GO:0043169,GO:0043173,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.11.1,3.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000005997 237.0
TLS1_k127_4538130_16 adenylylsulfate kinase activity K00860,K00955 - 2.7.1.25,2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000003056 228.0
TLS1_k127_4538130_17 IMP dehydrogenase activity K07182 - - 0.0000000000000000000000000000000000000000000000000000000003762 206.0
TLS1_k127_4538130_18 Divalent cation transporter K06213 - - 0.0000000000000000000000000000000000000000000000000004357 196.0
TLS1_k127_4538130_19 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000006138 179.0
TLS1_k127_4538130_2 PFAM SNF2-related protein - - - 2.192e-241 789.0
TLS1_k127_4538130_20 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000006295 194.0
TLS1_k127_4538130_21 PFAM blue (type 1) copper domain protein K00368 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1 0.000000000000000000000000000000000000000001446 160.0
TLS1_k127_4538130_22 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000002704 156.0
TLS1_k127_4538130_23 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12263 - - 0.00000000000000000000000000000000000000007408 156.0
TLS1_k127_4538130_24 IMP dehydrogenase activity K07182 - - 0.00000000000000000000000000000000000707 141.0
TLS1_k127_4538130_25 PFAM Pentapeptide repeats (8 copies) - - - 0.0000000000000000000000000000000003849 148.0
TLS1_k127_4538130_26 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000001427 132.0
TLS1_k127_4538130_27 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000004331 119.0
TLS1_k127_4538130_28 Universal stress protein - - - 0.0000000000000000000000000488 119.0
TLS1_k127_4538130_3 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008996 600.0
TLS1_k127_4538130_31 DNA-binding transcription factor activity - - - 0.000000002209 62.0
TLS1_k127_4538130_4 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 597.0
TLS1_k127_4538130_5 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 504.0
TLS1_k127_4538130_6 alcohol dehydrogenase K00001,K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 449.0
TLS1_k127_4538130_8 Hypothetical methyltransferase K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 359.0
TLS1_k127_4538130_9 AMP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 337.0
TLS1_k127_4540598_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000000001215 76.0
TLS1_k127_4543029_0 aldehyde-lyase activity K01621 - 4.1.2.22,4.1.2.9 0.0 1387.0
TLS1_k127_4543029_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000001143 144.0
TLS1_k127_4549197_0 response regulator K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004779 247.0
TLS1_k127_4549197_1 Response regulator receiver - - - 0.0000000000000000000000403 104.0
TLS1_k127_4549197_2 peptidase - - - 0.00000000000000000001205 95.0
TLS1_k127_4549197_3 Histidine kinase K07683 - 2.7.13.3 0.00000000000007159 74.0
TLS1_k127_4549197_4 YtxH-like protein - - - 0.0004207 45.0
TLS1_k127_4554151_0 DNA RNA polymerases superfamily protein - GO:0000943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003887,GO:0003964,GO:0004518,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006278,GO:0006508,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019538,GO:0032196,GO:0032197,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140096,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576 - 0.000000000000000000000000000001691 138.0
TLS1_k127_4554925_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1097.0
TLS1_k127_4554925_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 3.343e-242 753.0
TLS1_k127_4554925_10 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006498 296.0
TLS1_k127_4554925_11 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 284.0
TLS1_k127_4554925_12 signal-transduction protein containing cAMP-binding and CBS domains K02342,K05847,K07182 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000005059 215.0
TLS1_k127_4554925_13 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000002411 214.0
TLS1_k127_4554925_14 CobQ CobB MinD ParA nucleotide binding domain - - - 0.000000000001347 78.0
TLS1_k127_4554925_15 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000008959 68.0
TLS1_k127_4554925_16 export protein K01991 - - 0.0000000006228 70.0
TLS1_k127_4554925_2 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 3.964e-205 647.0
TLS1_k127_4554925_3 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 2.281e-198 631.0
TLS1_k127_4554925_4 Competence protein K02238 - - 7.681e-195 636.0
TLS1_k127_4554925_5 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 537.0
TLS1_k127_4554925_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 439.0
TLS1_k127_4554925_7 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 378.0
TLS1_k127_4554925_8 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008354 354.0
TLS1_k127_4554925_9 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 345.0
TLS1_k127_456477_0 unnamed protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 283.0
TLS1_k127_456477_1 - - - - 0.00000000000000000000000000000000000000000000000000000002489 200.0
TLS1_k127_456477_2 - - - - 0.00000000000000000000000000000000000000000007789 159.0
TLS1_k127_456477_3 - - - - 0.0000000000000000000000000000000000000007295 148.0
TLS1_k127_456477_4 - - - - 0.0000000000000000000000000000000000002042 140.0
TLS1_k127_456477_5 - - - - 0.00000000000000000000000001474 113.0
TLS1_k127_456477_6 - - - - 0.00000000000000000000004315 101.0
TLS1_k127_456477_7 - - - - 0.000000000000000000008251 91.0
TLS1_k127_456477_8 - - - - 0.00004913 47.0
TLS1_k127_4584248_0 PFAM transposase IS116 IS110 IS902 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 472.0
TLS1_k127_4584248_1 - - - - 0.00000000001001 66.0
TLS1_k127_4590944_0 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 484.0
TLS1_k127_4590944_1 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000005703 158.0
TLS1_k127_462713_0 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 430.0
TLS1_k127_462713_1 peptidase K02557,K21471 - - 0.00000000000000000000000000000000005407 150.0
TLS1_k127_4633427_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 5.68e-209 653.0
TLS1_k127_4634557_0 response regulator K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006195 497.0
TLS1_k127_4634557_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000006379 103.0
TLS1_k127_4658721_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - 0.0 1049.0
TLS1_k127_4658721_1 PFAM Integrase, catalytic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 488.0
TLS1_k127_4658721_10 YtxH-like protein - - - 0.00005166 50.0
TLS1_k127_4658721_2 IstB domain protein ATP-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 367.0
TLS1_k127_4658721_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004802 248.0
TLS1_k127_4658721_4 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000002045 217.0
TLS1_k127_4658721_5 Polynucleotide kinase 3 phosphatase - - - 0.00000000000000000000003876 104.0
TLS1_k127_4658721_6 Transposase IS116/IS110/IS902 family - GO:0003674,GO:0003824,GO:0004803,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.00000000000000000004941 90.0
TLS1_k127_4658721_7 - - - - 0.0000000000000004283 85.0
TLS1_k127_4658721_8 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.0000000008937 66.0
TLS1_k127_4658721_9 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000001415 57.0
TLS1_k127_466500_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1414.0
TLS1_k127_466500_11 AntiSigma factor - - - 0.00000000000000000000000004027 111.0
TLS1_k127_466500_12 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00000000004207 72.0
TLS1_k127_466500_13 Binds directly to 16S ribosomal RNA K02968 - - 0.000000001608 64.0
TLS1_k127_466500_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 3.744e-204 644.0
TLS1_k127_466500_3 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 364.0
TLS1_k127_466500_4 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004879 370.0
TLS1_k127_466500_5 phosphonoacetaldehyde hydrolase activity K20881 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009191 321.0
TLS1_k127_466500_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 287.0
TLS1_k127_466500_7 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004168 285.0
TLS1_k127_466500_8 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001398 264.0
TLS1_k127_4667173_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999,K11959 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 604.0
TLS1_k127_4667173_1 Belongs to the binding-protein-dependent transport system permease family K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 383.0
TLS1_k127_4667173_2 Urea ABC transporter permease K11960 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 363.0
TLS1_k127_4667173_3 TIGRFAM urea ABC transporter, ATP-binding protein UrtD K11962 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001342 278.0
TLS1_k127_4667173_4 ABC transporter K11963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001606 249.0
TLS1_k127_4670074_0 transposition K07497 - - 0.000000000000000000000000000001152 127.0
TLS1_k127_4670074_1 antibiotic catabolic process - - - 0.00000000004494 74.0
TLS1_k127_4702021_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001222 256.0
TLS1_k127_4711655_0 response regulator K02479,K07684,K07685 - - 0.0000000000000000000000000000000000000004752 157.0
TLS1_k127_4711655_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000002465 126.0
TLS1_k127_4711655_2 PFAM transposase, IS4 family protein K07481 - - 0.0000000003071 61.0
TLS1_k127_4719240_0 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0 1501.0
TLS1_k127_4719240_1 Histidine kinase - - - 1.28e-314 975.0
TLS1_k127_4719240_2 PFAM Formylglycine-generating sulfatase enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 533.0
TLS1_k127_4719240_3 serine-type endopeptidase activity K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 471.0
TLS1_k127_4719240_4 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 446.0
TLS1_k127_4719240_5 PFAM Formylglycine-generating sulfatase enzyme K20333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 419.0
TLS1_k127_4719240_6 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481,K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 393.0
TLS1_k127_4719240_7 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 355.0
TLS1_k127_4719240_8 antisigma factor binding K03598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002982 278.0
TLS1_k127_4719837_0 Integrase, catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006646 522.0
TLS1_k127_4719837_1 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.0000002191 54.0
TLS1_k127_4768448_0 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 316.0
TLS1_k127_4768448_1 transposition - - - 0.000000000000000000000000000000000000139 159.0
TLS1_k127_4770598_0 PFAM Alcohol dehydrogenase - - - 6.485e-202 633.0
TLS1_k127_4770598_1 Domain of Unknown Function (DUF748) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 387.0
TLS1_k127_4770598_10 Protein of unknown function (DUF421) - - - 0.00000000004026 70.0
TLS1_k127_4770598_2 isochorismatase, hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006936 293.0
TLS1_k127_4770598_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007685 263.0
TLS1_k127_4770598_4 FAD dependent oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000005979 173.0
TLS1_k127_4770598_5 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions - - - 0.00000000000000000000000000000001971 129.0
TLS1_k127_4770598_6 hemerythrin HHE cation binding domain - - - 0.0000000000000000000000004558 110.0
TLS1_k127_4770598_7 Polynucleotide kinase 3 phosphatase - - - 0.00000000000000000007857 92.0
TLS1_k127_4770598_8 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K10936,K16079 - - 0.0000000000000401 83.0
TLS1_k127_4770598_9 - - - - 0.000000000004231 69.0
TLS1_k127_4778774_0 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007526 548.0
TLS1_k127_4778774_1 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 369.0
TLS1_k127_4778774_2 OsmC-like protein K09136 - - 0.00000000000000000000000000000000000000000000000000000000000001216 217.0
TLS1_k127_4778774_3 Cytochrome c K12263 - - 0.0000000000000000000000001919 111.0
TLS1_k127_4791136_0 YqcI/YcgG family K09190 - - 0.0000000000000000000000000000000000000000000000000000002397 204.0
TLS1_k127_4791136_1 Domain of unknown function (DUF1989) - - - 0.0000000000001338 74.0
TLS1_k127_4815481_0 COG NOG14600 non supervised orthologous group - - - 0.0000000000000000000000000000000000000000000006906 166.0
TLS1_k127_4815481_2 Tetratricopeptide repeat - - - 0.00001409 51.0
TLS1_k127_4816293_0 peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000002232 91.0
TLS1_k127_4828175_0 chaperone-mediated protein complex assembly K00373,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 601.0
TLS1_k127_4833056_0 Transposase IS116 IS110 IS902 - - - 0.00000000000000000000000000000000000000008333 153.0
TLS1_k127_483332_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1313.0
TLS1_k127_483332_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1118.0
TLS1_k127_483332_10 oxidoreductase activity, acting on diphenols and related substances as donors K00240,K03886 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 488.0
TLS1_k127_483332_11 Cytochrome c K02305,K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 430.0
TLS1_k127_483332_12 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 413.0
TLS1_k127_483332_13 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 395.0
TLS1_k127_483332_14 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 387.0
TLS1_k127_483332_15 Ethylbenzene dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 377.0
TLS1_k127_483332_16 Cytochrome c K08738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 304.0
TLS1_k127_483332_18 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 289.0
TLS1_k127_483332_19 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001756 284.0
TLS1_k127_483332_2 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 0.0 1090.0
TLS1_k127_483332_20 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005669 272.0
TLS1_k127_483332_21 Cytochrome c K17052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004663 266.0
TLS1_k127_483332_22 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000001594 238.0
TLS1_k127_483332_23 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000004032 233.0
TLS1_k127_483332_25 adenosylhomocysteine nucleosidase activity K01243,K03527 - 1.17.7.4,3.2.2.9 0.00000000000000000000000000000000000000000005938 170.0
TLS1_k127_483332_26 - - - - 0.0000000000000000000000000000000000000354 147.0
TLS1_k127_483332_27 phosphatidylinositol metabolic process K00728 - 2.4.1.109 0.000000000000000000000000000000002963 144.0
TLS1_k127_483332_3 aerobic electron transport chain K00425,K08738 - 1.10.3.14 1.817e-320 991.0
TLS1_k127_483332_4 aerobic electron transport chain K00425,K08738 - 1.10.3.14 2.643e-254 794.0
TLS1_k127_483332_5 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 1.89e-215 673.0
TLS1_k127_483332_6 Cytochrome b/b6/petB K00412 - - 5.61e-206 645.0
TLS1_k127_483332_7 Domain of unknown function (DUF3463) - - - 1.637e-203 635.0
TLS1_k127_483332_8 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008108 563.0
TLS1_k127_483332_9 Surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 553.0
TLS1_k127_4835349_0 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 342.0
TLS1_k127_4835349_1 AAA domain K02450 - - 0.000000000002633 70.0
TLS1_k127_4844034_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 569.0
TLS1_k127_4844034_2 ribosomal large subunit export from nucleus - - - 0.0000000000000000000000000000000000000000000000001399 181.0
TLS1_k127_4844034_3 IMP dehydrogenase activity K09137 - - 0.00000000000000000000000000000000000000001503 157.0
TLS1_k127_4844034_4 RNA-binding protein - - - 0.00000000005356 66.0
TLS1_k127_4844034_5 peptidase - - - 0.000000007617 62.0
TLS1_k127_4850116_0 ATPase activity - - - 1.163e-263 819.0
TLS1_k127_4850116_1 Probable molybdopterin binding domain K03750 - 2.10.1.1 1.363e-228 713.0
TLS1_k127_4850116_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 451.0
TLS1_k127_4850116_11 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 443.0
TLS1_k127_4850116_12 macromolecule localization K01421,K01992,K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 409.0
TLS1_k127_4850116_13 Evidence 5 No homology to any previously reported sequences K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 424.0
TLS1_k127_4850116_14 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 376.0
TLS1_k127_4850116_15 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 372.0
TLS1_k127_4850116_16 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 377.0
TLS1_k127_4850116_17 denitrification pathway K02569,K03532,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 355.0
TLS1_k127_4850116_18 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 346.0
TLS1_k127_4850116_19 Transposase K01991,K02557,K07161,K07484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 329.0
TLS1_k127_4850116_2 Periplasmic binding protein - - - 1.236e-227 722.0
TLS1_k127_4850116_20 2OG-Fe(II) oxygenase superfamily K07394 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 308.0
TLS1_k127_4850116_21 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 289.0
TLS1_k127_4850116_22 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001875 288.0
TLS1_k127_4850116_23 Outer membrane lipoprotein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004452 274.0
TLS1_k127_4850116_24 Mo-molybdopterin cofactor metabolic process K03750,K03753,K13818 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.10.1.1,2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000001335 265.0
TLS1_k127_4850116_25 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001013 247.0
TLS1_k127_4850116_27 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006103 252.0
TLS1_k127_4850116_28 cysteine-type peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001823 250.0
TLS1_k127_4850116_29 Domain of unknown function (DUF5069) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000384 239.0
TLS1_k127_4850116_3 Trypsin K04771 - 3.4.21.107 5.757e-226 709.0
TLS1_k127_4850116_30 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000004746 235.0
TLS1_k127_4850116_31 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000000000000000000002193 233.0
TLS1_k127_4850116_32 Biopolymer transport protein ExbD/TolR K03560 - - 0.00000000000000000000000000000000000000000000000000000000000000004545 224.0
TLS1_k127_4850116_33 energy transducer activity K03646,K03832 - - 0.00000000000000000000000000000000000000000000000000000000000002335 229.0
TLS1_k127_4850116_35 - - - - 0.00000000000000000000000000000000000000000000000000003853 190.0
TLS1_k127_4850116_36 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000001395 194.0
TLS1_k127_4850116_37 Evidence 2b Function of strongly homologous gene K18139 - - 0.000000000000000000000000000000000000000000000000003312 184.0
TLS1_k127_4850116_39 IPT/TIG domain - - - 0.00000000000000000000000000000000000000000002112 183.0
TLS1_k127_4850116_4 WD40-like Beta Propeller Repeat K03641 - - 1.411e-217 681.0
TLS1_k127_4850116_40 RNA recognition motif - - - 0.000000000000000000000000000000000000000002282 164.0
TLS1_k127_4850116_41 Response regulator, receiver - - - 0.000000000000000000000000000000003977 135.0
TLS1_k127_4850116_42 - - - - 0.00000000000000000000000000000001003 138.0
TLS1_k127_4850116_43 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000009839 112.0
TLS1_k127_4850116_44 Methyltransferase domain - - - 0.000000000000000003482 93.0
TLS1_k127_4850116_46 - - - - 0.000000000002232 69.0
TLS1_k127_4850116_47 PEGA domain - - - 0.0000008195 57.0
TLS1_k127_4850116_5 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.041e-202 649.0
TLS1_k127_4850116_50 - - - - 0.0009645 43.0
TLS1_k127_4850116_6 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 603.0
TLS1_k127_4850116_7 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 552.0
TLS1_k127_4850116_8 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004098 546.0
TLS1_k127_4850116_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 459.0
TLS1_k127_4866653_0 Type II/IV secretion system protein K02454,K02652 - - 0.00000000000000000000000000000000003189 134.0
TLS1_k127_4866653_2 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.00000000006944 66.0
TLS1_k127_4885077_0 aerobic electron transport chain K00425,K08738 - 1.10.3.14 1.678e-286 891.0
TLS1_k127_4885077_1 rRNA (guanine-N2-)-methyltransferase activity K09846,K13604,K21460 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.210,2.1.1.304,2.1.1.333 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 461.0
TLS1_k127_4885077_2 membrane K08976 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 367.0
TLS1_k127_4885077_6 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000003245 197.0
TLS1_k127_4923603_0 methylisocitrate lyase activity K01841,K07281 - 2.7.7.74,5.4.2.9 1.488e-303 935.0
TLS1_k127_4923603_1 Iron permease FTR1 family K07243 - - 1.855e-264 825.0
TLS1_k127_4923603_10 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000004725 235.0
TLS1_k127_4923603_11 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000016 207.0
TLS1_k127_4923603_12 phosphate starvation-inducible protein, PsiF - - - 0.00000000000000000000003934 102.0
TLS1_k127_4923603_13 YacP-like NYN domain K06962 - - 0.0000000000000000000005522 104.0
TLS1_k127_4923603_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 8.209e-243 758.0
TLS1_k127_4923603_3 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 557.0
TLS1_k127_4923603_4 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 416.0
TLS1_k127_4923603_5 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000748 376.0
TLS1_k127_4923603_6 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 361.0
TLS1_k127_4923603_7 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 368.0
TLS1_k127_4923603_8 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 317.0
TLS1_k127_4923603_9 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 308.0
TLS1_k127_4932450_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 346.0
TLS1_k127_4932450_1 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit B K10945 - - 0.00000000000000000000000000000000000000000007738 163.0
TLS1_k127_49362_0 Type II secretory pathway component ExeA - - - 0.00000000000000000000000000000000000000000000000000000000004109 212.0
TLS1_k127_49362_1 PFAM metal-dependent phosphohydrolase, HD sub domain K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000008071 189.0
TLS1_k127_4941053_0 IS30 family K07482 - - 0.0000000000000000000000000000009076 134.0
TLS1_k127_4967946_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 7.236e-202 639.0
TLS1_k127_4967946_2 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008601 367.0
TLS1_k127_4967946_3 bacterial-type flagellum organization K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009956 366.0
TLS1_k127_4967946_4 oxidoreductase activity K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 345.0
TLS1_k127_4967946_5 transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 339.0
TLS1_k127_4967946_6 Dioxygenase K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002828 274.0
TLS1_k127_4967946_7 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K16079 - - 0.0000000000000000000000000000000000000000000000000000009719 199.0
TLS1_k127_4967946_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.00000000000000000000000000000448 129.0
TLS1_k127_4967946_9 rRNA binding K00185,K02967 - - 0.000000000000006814 89.0
TLS1_k127_4991008_0 siderophore transport K02014 - - 5.876e-264 821.0
TLS1_k127_4991008_1 TonB dependent receptor K02014 - - 7.047e-222 714.0
TLS1_k127_4991008_10 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0000000000000000000000000000000000005819 144.0
TLS1_k127_4991008_11 Iron permease FTR1 family K07243 - - 0.0000000000000000000000000000001634 127.0
TLS1_k127_4991008_12 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000000000000000001937 128.0
TLS1_k127_4991008_13 energy transducer activity K03832 - - 0.000000000000000000000000001779 123.0
TLS1_k127_4991008_14 Ferric uptake regulator family K03711 - - 0.00000000000000000000001685 104.0
TLS1_k127_4991008_15 cobalamin synthesis protein P47K - - - 0.0000000000000000000002746 109.0
TLS1_k127_4991008_16 biopolymer transport protein K03559 - - 0.0000000000000000001614 93.0
TLS1_k127_4991008_18 chaperone-mediated protein complex assembly - - - 0.00000000000000001838 85.0
TLS1_k127_4991008_19 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000276 71.0
TLS1_k127_4991008_2 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 554.0
TLS1_k127_4991008_3 Cobalamin synthesis protein cobW C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 475.0
TLS1_k127_4991008_4 Iron-regulated membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 371.0
TLS1_k127_4991008_5 bacteriocin transport K03561,K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000004502 218.0
TLS1_k127_4991008_6 transporter K07238,K11021,K16267 - - 0.00000000000000000000000000000000000000000000000000000000003075 214.0
TLS1_k127_4991008_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000165 198.0
TLS1_k127_4991008_8 Anaphase-promoting complex subunit 4 WD40 domain - - - 0.00000000000000000000000000000000000000000000002357 184.0
TLS1_k127_5009330_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1397.0
TLS1_k127_5009330_1 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0 1159.0
TLS1_k127_5009330_10 Cytochrome c - - - 5.62e-198 620.0
TLS1_k127_5009330_11 anaphase-promoting complex binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 599.0
TLS1_k127_5009330_12 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 567.0
TLS1_k127_5009330_13 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003034 527.0
TLS1_k127_5009330_14 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 520.0
TLS1_k127_5009330_15 protein complex oligomerization - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 515.0
TLS1_k127_5009330_16 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 487.0
TLS1_k127_5009330_17 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 479.0
TLS1_k127_5009330_18 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 437.0
TLS1_k127_5009330_19 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 427.0
TLS1_k127_5009330_2 Type I restriction-modification system methyltransferase subunit - - - 0.0 1134.0
TLS1_k127_5009330_20 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008209 309.0
TLS1_k127_5009330_21 peroxiredoxin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 312.0
TLS1_k127_5009330_23 4 iron, 4 sulfur cluster binding K02573 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007971 273.0
TLS1_k127_5009330_24 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001832 267.0
TLS1_k127_5009330_25 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000004231 250.0
TLS1_k127_5009330_26 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000112 210.0
TLS1_k127_5009330_27 Belongs to the HesB IscA family K15724 - - 0.00000000000000000000000000000000000000000000000000000001278 198.0
TLS1_k127_5009330_29 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000004757 167.0
TLS1_k127_5009330_3 Cytochrome c K00405 - - 3.874e-317 978.0
TLS1_k127_5009330_30 Preprotein translocase subunit K03210 - - 0.000000000000000000000000000000000000008534 150.0
TLS1_k127_5009330_33 - - - - 0.000000000000000000000000000000004799 136.0
TLS1_k127_5009330_34 DEAD-like helicases superfamily K07012 - - 0.000000000000000000000000004139 130.0
TLS1_k127_5009330_35 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.0000000000000000000000004633 105.0
TLS1_k127_5009330_36 Nucleotidyltransferase domain K07076 - - 0.0000000000000000000000004739 109.0
TLS1_k127_5009330_37 HEPN domain - - - 0.00000000000000000000001291 104.0
TLS1_k127_5009330_38 GGDEF domain containing protein - - - 0.000000000000000000000289 110.0
TLS1_k127_5009330_39 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000005569 104.0
TLS1_k127_5009330_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 7.375e-260 809.0
TLS1_k127_5009330_40 CsbD-like - - - 0.00000000000001318 77.0
TLS1_k127_5009330_41 phosphorelay signal transduction system - - - 0.00000000000003564 78.0
TLS1_k127_5009330_43 Protein of unknown function (DUF1328) - - - 0.00001857 51.0
TLS1_k127_5009330_44 - - - - 0.0000421 53.0
TLS1_k127_5009330_45 AAA-like domain - - - 0.0002207 45.0
TLS1_k127_5009330_5 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 4.19e-249 780.0
TLS1_k127_5009330_6 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 7.274e-229 715.0
TLS1_k127_5009330_7 Cytochrome c K00405 - - 6.44e-211 662.0
TLS1_k127_5009330_8 - - - - 3.385e-206 642.0
TLS1_k127_5009330_9 phosphorelay signal transduction system - - - 3.951e-205 649.0
TLS1_k127_5010256_0 methyltransferase - - - 1.207e-267 829.0
TLS1_k127_5010256_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 345.0
TLS1_k127_5010256_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001631 273.0
TLS1_k127_5010256_3 protein homooligomerization - - - 0.0000000000000000000000000000000000000000000000000000000000000000000823 243.0
TLS1_k127_5010256_4 PFAM blue (type 1) copper domain protein K00368 - 1.7.2.1 0.0000000000000000000000000000000000001048 145.0
TLS1_k127_5028075_0 PFAM Transposase, IS4-like - - - 0.000955 49.0
TLS1_k127_5058713_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.384e-240 747.0
TLS1_k127_5058713_1 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 504.0
TLS1_k127_5058713_10 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003701 274.0
TLS1_k127_5058713_11 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005378 271.0
TLS1_k127_5058713_12 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000001061 213.0
TLS1_k127_5058713_13 Domain of unknown function (DUF309) K09763 - - 0.000000000000000000000000000000000000000000007073 168.0
TLS1_k127_5058713_14 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000000004198 130.0
TLS1_k127_5058713_15 Putative addiction module component - - - 0.00000000000000000003989 93.0
TLS1_k127_5058713_16 Plasmid stabilization system - - - 0.0000000009836 61.0
TLS1_k127_5058713_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 499.0
TLS1_k127_5058713_3 Acyl transferase domain K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 460.0
TLS1_k127_5058713_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 402.0
TLS1_k127_5058713_5 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 398.0
TLS1_k127_5058713_6 6-phosphogluconolactonase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004025 362.0
TLS1_k127_5058713_7 phosphoprotein phosphatase activity K01525 GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 346.0
TLS1_k127_5058713_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 342.0
TLS1_k127_5058713_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 336.0
TLS1_k127_5060332_0 - - - - 0.00000000000000000001738 97.0
TLS1_k127_5060332_1 - - - - 0.00000000000000547 75.0
TLS1_k127_5062031_0 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 487.0
TLS1_k127_5062031_1 eRF1 domain 3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 378.0
TLS1_k127_5062031_2 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007529 388.0
TLS1_k127_5062031_3 beta-Ig-H3 fasciclin - - - 0.00000000000000000000000003832 113.0
TLS1_k127_5062031_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000002815 111.0
TLS1_k127_506522_0 Ferredoxin - - - 0.0000000000000000000000000000003005 129.0
TLS1_k127_5075371_0 COG3385 FOG Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 533.0
TLS1_k127_5078907_0 - - - - 0.00000000000000000000001502 102.0
TLS1_k127_5078907_1 - - - - 0.00000000000000002345 85.0
TLS1_k127_5078907_2 - - - - 0.000000000000003698 77.0
TLS1_k127_5088613_0 Beta-Casp domain K07576 - - 3.671e-238 744.0
TLS1_k127_5088613_1 aminopeptidase activity K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 568.0
TLS1_k127_5088613_10 Peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000002948 191.0
TLS1_k127_5088613_14 acetyltransferase - - - 0.00000000000000000000000000000000000000000000632 168.0
TLS1_k127_5088613_16 tetraacyldisaccharide 4'-kinase activity K09791 - - 0.00000000000000000000000000006958 118.0
TLS1_k127_5088613_17 peptidyl-tyrosine sulfation - - - 0.00000000000008086 74.0
TLS1_k127_5088613_18 - - - - 0.000000000000282 76.0
TLS1_k127_5088613_2 FIST C domain - GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 463.0
TLS1_k127_5088613_3 Aminomethyltransferase folate-binding domain K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 443.0
TLS1_k127_5088613_4 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 409.0
TLS1_k127_5088613_5 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 405.0
TLS1_k127_5088613_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00371,K16965,K17048,K17051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 344.0
TLS1_k127_5088613_7 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002546 276.0
TLS1_k127_5088613_8 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000001526 226.0
TLS1_k127_5095730_0 ATP-dependent transcriptional regulator, MalT-like, LuxR family K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 303.0
TLS1_k127_5114813_0 pilus assembly protein PilW K02672 - - 0.0000000000000000000000000000000000000000000000008169 189.0
TLS1_k127_511602_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 537.0
TLS1_k127_511602_1 Cellulose synthase K00694,K20541 - 2.4.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 385.0
TLS1_k127_511602_2 branched-chain-amino-acid transaminase activity K00824 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 339.0
TLS1_k127_511602_3 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002065 242.0
TLS1_k127_511602_5 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000000000000000002463 209.0
TLS1_k127_511602_6 MEKHLA domain - - - 0.0000000000000000000000000000000000000000000000000000000009266 205.0
TLS1_k127_511602_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.000000000000000000000000000000000000000000000000005274 182.0
TLS1_k127_511602_9 CBS-domain-containing membrane protein K07168 - - 0.00000000003399 72.0
TLS1_k127_5124231_0 AMP binding - - - 0.00000000000000000000005398 102.0
TLS1_k127_5124231_1 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000005871 88.0
TLS1_k127_5131389_0 Rubrerythrin K22405 - 1.6.3.4 0.0 1202.0
TLS1_k127_5131389_1 Iron-sulfur cluster-binding domain - - - 3.866e-273 844.0
TLS1_k127_5131389_2 Elongator protein 3, MiaB family, Radical SAM - - - 1.784e-262 812.0
TLS1_k127_5134015_0 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0 1025.0
TLS1_k127_5135707_0 PFAM YaeQ family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000008284 226.0
TLS1_k127_5135707_1 endonuclease activity K03465 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.1.1.148 0.0000000000000000000000000000000000000000000004398 168.0
TLS1_k127_5135707_2 conserved protein (DUF2132) K06867 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.00000000000000000000000004849 111.0
TLS1_k127_5139621_0 IMG reference gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 498.0
TLS1_k127_5139621_1 PFAM Integrase catalytic - - - 0.0000000000000001804 82.0
TLS1_k127_5141200_0 reverse transcriptase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005073 250.0
TLS1_k127_5143327_2 Belongs to the 'phage' integrase family - - - 0.0000000001038 65.0
TLS1_k127_5143358_0 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 1.228e-221 697.0
TLS1_k127_5143358_1 FtsZ-dependent cytokinesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 334.0
TLS1_k127_5143358_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000002527 78.0
TLS1_k127_5145709_0 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 550.0
TLS1_k127_5145709_1 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000001705 199.0
TLS1_k127_5152253_0 - - - - 0.0000000000000000000000000000000000000000000001186 184.0
TLS1_k127_5171948_0 ATPase associated with various cellular activities, AAA_5 K02584 - - 2.626e-220 701.0
TLS1_k127_5171948_1 PBP superfamily domain K03750,K07219 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 424.0
TLS1_k127_5171948_10 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000000000000000000000000009549 184.0
TLS1_k127_5171948_11 phosphorelay signal transduction system K02535 - 3.5.1.108 0.00000000000000000000000000000000007527 137.0
TLS1_k127_5171948_13 Histidine kinase-like ATPases - - - 0.0000000000000000006304 94.0
TLS1_k127_5171948_2 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 356.0
TLS1_k127_5171948_3 Protein of unknown function (DUF1264) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 331.0
TLS1_k127_5171948_4 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 283.0
TLS1_k127_5171948_5 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004172 297.0
TLS1_k127_5171948_6 TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004145 262.0
TLS1_k127_5171948_7 Represses a number of genes involved in the response to DNA damage (SOS response) K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000493 242.0
TLS1_k127_5171948_8 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000000000000001846 244.0
TLS1_k127_517729_0 source UniProtKB - - - 2.158e-311 989.0
TLS1_k127_5185380_0 Major facilitator Superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 337.0
TLS1_k127_5185380_1 positive regulation of type IV pilus biogenesis K07343 - - 0.0000000000000000000000000000000003189 133.0
TLS1_k127_5198576_0 Actin K03569 - - 7.845e-204 638.0
TLS1_k127_5198576_1 shape-determining protein MreC K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 304.0
TLS1_k127_5198576_2 RDD family - - - 0.00000000000000000000000000000000000000000000000000005796 190.0
TLS1_k127_5198576_3 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000003985 153.0
TLS1_k127_5201327_0 Type II/IV secretion system protein K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 601.0
TLS1_k127_5201327_1 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 359.0
TLS1_k127_5201327_2 Pilus assembly protein PilX K07140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005287 361.0
TLS1_k127_5201327_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006383 280.0
TLS1_k127_5201327_4 Putative Competence protein ComGF K02246,K02248 - - 0.00000000000000000000000000000002437 135.0
TLS1_k127_5201327_5 pilus assembly protein PilW K02672 - - 0.00000000000000000000000000000006349 136.0
TLS1_k127_5201327_6 response regulator K03413 - - 0.0000000000000000000000000002064 117.0
TLS1_k127_5201327_7 protein transport across the cell outer membrane K02457,K02672,K08084,K08085 - - 0.0000000000000000000776 96.0
TLS1_k127_5207382_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 3.125e-312 967.0
TLS1_k127_5207382_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 1.183e-210 657.0
TLS1_k127_5207382_2 The glycine cleavage system catalyzes the degradation of glycine K00605,K06980,K22086 - 1.5.99.5,2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 536.0
TLS1_k127_5207382_3 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 488.0
TLS1_k127_5207382_4 photosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 298.0
TLS1_k127_5207382_5 GGDEF domain - - - 0.00000000000000000000000000000000000000000000003937 172.0
TLS1_k127_5207382_6 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000002755 170.0
TLS1_k127_5207382_7 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000001054 159.0
TLS1_k127_5207382_8 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000006426 74.0
TLS1_k127_5211316_0 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 385.0
TLS1_k127_5211316_1 PIN domain - - - 0.000000000000000005993 87.0
TLS1_k127_5211316_2 SpoVT / AbrB like domain - - - 0.0000000000000939 73.0
TLS1_k127_5211980_0 - - - - 0.0000000000000000000000004708 109.0
TLS1_k127_5211980_1 PFAM Transposase K07481 - - 0.0000000000000000000000183 114.0
TLS1_k127_5212884_0 Membrane-bound serine protease (ClpP class) K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 470.0
TLS1_k127_5212884_1 SPFH domain-Band 7 family - - - 0.000000000000000000000000000000000116 134.0
TLS1_k127_5221315_0 membrane-associated protein domain - - - 0.0000000000000000000000000000004505 142.0
TLS1_k127_5221315_1 WD40 domain protein beta Propeller K03641 - - 0.000000000000000000000002742 120.0
TLS1_k127_5221315_2 translation release factor activity - - - 0.00000000000745 66.0
TLS1_k127_52246_0 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000001218 211.0
TLS1_k127_52246_1 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000002494 183.0
TLS1_k127_52246_2 Methyltransferase domain - - - 0.00000000000000000001032 103.0
TLS1_k127_52246_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000002949 104.0
TLS1_k127_52246_4 3-demethylubiquinone-9 3-O-methyltransferase activity K15257 - - 0.0000000000877 74.0
TLS1_k127_5229455_10 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.00013 51.0
TLS1_k127_5229455_2 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001862 261.0
TLS1_k127_5229455_3 AhpC/TSA family K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000003697 226.0
TLS1_k127_5229455_4 Cyclophilin-like K09143 - - 0.0000000000000000000000000000000000000000000000000000004397 195.0
TLS1_k127_5229455_5 protein serine/threonine phosphatase activity K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000001724 198.0
TLS1_k127_5229455_6 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000002495 139.0
TLS1_k127_5229455_7 Protein of unknown function (DUF507) - - - 0.000000000000000000000000000000225 125.0
TLS1_k127_5229455_8 Protein of unknown function (DUF507) - - - 0.00000000000000000000002742 102.0
TLS1_k127_5229455_9 - - - - 0.00000000000000000001881 99.0
TLS1_k127_5229517_0 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 349.0
TLS1_k127_5229517_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005141 278.0
TLS1_k127_5229517_2 - - - - 0.000000000000000000000000000000000000000000000000000000000001034 229.0
TLS1_k127_5229517_3 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000001201 196.0
TLS1_k127_5230118_0 Tim44 K15539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 357.0
TLS1_k127_5230118_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 288.0
TLS1_k127_5230452_0 Bacterial regulatory protein, Fis family K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008302 393.0
TLS1_k127_5230452_1 Integral membrane protein TerC family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000535 322.0
TLS1_k127_5230452_2 - - - - 0.0000005773 62.0
TLS1_k127_5231499_0 COG1653 ABC-type sugar transport system, periplasmic component K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 407.0
TLS1_k127_5239147_0 EcoEI R protein C-terminal K01153 - 3.1.21.3 0.0 1292.0
TLS1_k127_5239147_1 Protein of unknown function (DUF2281) - - - 0.000000000000000000000000001855 111.0
TLS1_k127_5239147_2 EcoEI R protein C-terminal K01153 - 3.1.21.3 0.000000000000004112 77.0
TLS1_k127_5242949_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000009128 232.0
TLS1_k127_5247142_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0 1053.0
TLS1_k127_5247142_1 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00382 - 1.8.1.4 4.149e-269 835.0
TLS1_k127_5247142_11 radical SAM domain protein K06871 - - 0.000000000000000001649 93.0
TLS1_k127_5247142_12 Protein of unknown function (DUF3047) - - - 0.0000000000006958 70.0
TLS1_k127_5247142_14 COG0463 Glycosyltransferases involved in cell wall biogenesis - - - 0.00009549 48.0
TLS1_k127_5247142_2 Sugar (and other) transporter K08178 - - 1.814e-210 660.0
TLS1_k127_5247142_3 imidazolonepropionase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007483 518.0
TLS1_k127_5247142_4 Evidence 2b Function of strongly homologous gene K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 507.0
TLS1_k127_5247142_5 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K07052 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 401.0
TLS1_k127_5247142_6 Pfam SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 293.0
TLS1_k127_5247142_7 heat shock protein binding K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001978 277.0
TLS1_k127_5247142_8 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000116 129.0
TLS1_k127_5247142_9 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - 0.00000000000000000000000000001951 117.0
TLS1_k127_5247738_0 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 9.071e-245 767.0
TLS1_k127_5247738_1 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 288.0
TLS1_k127_5247738_2 PFAM zinc iron permease K07238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001576 267.0
TLS1_k127_5247738_3 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000116 87.0
TLS1_k127_5247738_4 Domain of unknown function (DUF4142) K08995 - - 0.00000000000001141 81.0
TLS1_k127_5247738_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000003583 61.0
TLS1_k127_5247738_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00007929 53.0
TLS1_k127_5260940_0 HsdM N-terminal domain K03427 - 2.1.1.72 6.328e-235 730.0
TLS1_k127_5260940_1 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 569.0
TLS1_k127_5260940_2 Plasmid pRiA4b ORF-3-like protein - - - 0.0000000000000000000000000000000000000000000000004836 182.0
TLS1_k127_5260945_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.066e-235 735.0
TLS1_k127_5260945_1 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 365.0
TLS1_k127_5260945_10 Domain of unknown function (DUF4321) - - - 0.000000003017 59.0
TLS1_k127_5260945_2 Peptidase family M23 K21471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 360.0
TLS1_k127_5260945_3 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 349.0
TLS1_k127_5260945_4 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 325.0
TLS1_k127_5260945_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003014 270.0
TLS1_k127_5260945_6 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002967 199.0
TLS1_k127_5260945_7 ribosome binding K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000000251 186.0
TLS1_k127_5260945_8 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000008391 153.0
TLS1_k127_5260945_9 Uncharacterised protein family UPF0102 K07460 - - 0.000000000000000000000000000000003941 132.0
TLS1_k127_5261029_0 PFAM Transposase K07481 - - 0.0000000000000000003589 97.0
TLS1_k127_5264050_1 - - - - 0.000000000000000000000000002044 116.0
TLS1_k127_5264050_2 Belongs to the ompA family K02557,K03286 - - 0.0000000000000000000000006751 114.0
TLS1_k127_5264050_4 transposition K07497 - - 0.0000000000001251 71.0
TLS1_k127_5264050_5 - - - - 0.0000000392 63.0
TLS1_k127_5300025_0 molybdopterin cofactor binding K00370,K10700,K16964,K17050 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 0.0 1726.0
TLS1_k127_5300025_1 transmembrane transporter activity K18138 - - 0.0 1112.0
TLS1_k127_5300025_2 response regulator K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004396 258.0
TLS1_k127_5300025_3 Histidine kinase K07683 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000005823 256.0
TLS1_k127_5300025_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000007499 147.0
TLS1_k127_5306559_0 hydrolase activity, hydrolyzing O-glycosyl compounds K05341,K05343 - 2.4.1.4,3.2.1.1,5.4.99.16 2.197e-229 721.0
TLS1_k127_5306559_1 ROK family K00845,K00847 - 2.7.1.2,2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 344.0
TLS1_k127_5310538_0 K02A2.6-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000001575 264.0
TLS1_k127_5312941_1 acyl carrier protein K02078 - - 0.00000000000000000000001015 103.0
TLS1_k127_5312941_2 FAD dependent oxidoreductase - - - 0.00000000000000000000001706 101.0
TLS1_k127_5312941_3 BON domain K04065 - - 0.00000000000000000000001759 107.0
TLS1_k127_5312941_4 DDE domain - - - 0.0000000000000000000004112 98.0
TLS1_k127_5312941_5 UPF0391 membrane protein - - - 0.000000000000001769 77.0
TLS1_k127_5312941_6 Beta/Gamma crystallin - - - 0.00000000004335 68.0
TLS1_k127_5312941_7 FAD dependent oxidoreductase - - - 0.0000000001636 63.0
TLS1_k127_5312941_8 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K09471 - - 0.000004376 52.0
TLS1_k127_5317254_0 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 606.0
TLS1_k127_5317254_1 Proton-conducting membrane transporter K12137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 490.0
TLS1_k127_5317254_2 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 471.0
TLS1_k127_5317254_3 Hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 318.0
TLS1_k127_532548_0 ATP-dependent DNA helicase (RecQ) K03654 - 3.6.4.12 6.212e-279 871.0
TLS1_k127_532548_1 Protein involved in response to NO K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 435.0
TLS1_k127_532548_2 Domain of unknown function (DUF3482) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005562 334.0
TLS1_k127_532548_3 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000000000000002119 197.0
TLS1_k127_532548_4 Protein of unknown function (DUF2868) - - - 0.0000000000000000000000000000000000000000000000002288 194.0
TLS1_k127_5327379_0 Histidine Phosphotransfer domain - - - 0.000000114 62.0
TLS1_k127_5367140_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 6.834e-235 746.0
TLS1_k127_5367140_1 protein secretion by the type I secretion system K02021 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 618.0
TLS1_k127_5367140_10 Magnesium transport protein CorA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 391.0
TLS1_k127_5367140_11 Bacterial protein of unknown function (DUF839) K07093 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007896 388.0
TLS1_k127_5367140_12 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 370.0
TLS1_k127_5367140_13 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 345.0
TLS1_k127_5367140_15 signal-transduction protein containing cAMP-binding and CBS domains K00031,K14446 - 1.1.1.42,1.3.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000001708 269.0
TLS1_k127_5367140_16 Magnesium transport protein CorA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007483 260.0
TLS1_k127_5367140_17 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000001321 230.0
TLS1_k127_5367140_18 maF-like protein K03215,K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0030312,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0047429,GO:0071944 2.1.1.190 0.00000000000000000000000000000000000000000000000002638 186.0
TLS1_k127_5367140_19 CHAD - - - 0.0000000000000000000000000000000000000000000003338 185.0
TLS1_k127_5367140_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007217 563.0
TLS1_k127_5367140_20 Phosphate-starvation-inducible E - - - 0.00000000000000000000000000000000000000006542 156.0
TLS1_k127_5367140_21 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.000000000000000000000000000000000000003561 149.0
TLS1_k127_5367140_22 phosphohistidine phosphatase, SixA K08296 - - 0.0000000000000000000000000000000000001269 148.0
TLS1_k127_5367140_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 526.0
TLS1_k127_5367140_4 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 510.0
TLS1_k127_5367140_5 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 473.0
TLS1_k127_5367140_6 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05541 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 460.0
TLS1_k127_5367140_7 Protein of unknown function (DUF692) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 446.0
TLS1_k127_5367140_8 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 433.0
TLS1_k127_5367140_9 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005262 424.0
TLS1_k127_5367964_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1224.0
TLS1_k127_5367964_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 1.451e-312 968.0
TLS1_k127_5367964_10 - - - - 0.00000000000000000000000000000118 131.0
TLS1_k127_5367964_11 PFAM NAD dependent epimerase dehydratase family K08679 - 5.1.3.6 0.00000000000000000000000000004804 116.0
TLS1_k127_5367964_12 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000001466 112.0
TLS1_k127_5367964_13 Putative prokaryotic signal transducing protein - - - 0.000000000000000000003155 96.0
TLS1_k127_5367964_14 - - - - 0.00000000000002356 79.0
TLS1_k127_5367964_16 - - - - 0.00000001469 62.0
TLS1_k127_5367964_2 Rieske (2fe-2S) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009194 482.0
TLS1_k127_5367964_3 Formiminotransferase domain K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 446.0
TLS1_k127_5367964_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K01142,K10773 GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 351.0
TLS1_k127_5367964_5 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 310.0
TLS1_k127_5367964_6 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001207 244.0
TLS1_k127_5367964_7 - - - - 0.00000000000000000000000000000000000000000000000000001144 192.0
TLS1_k127_5367964_9 Sulfurtransferase TusA - - - 0.00000000000000000000000000000000000000003398 152.0
TLS1_k127_5388339_0 - - - - 0.000000000000000000000000000000000002691 141.0
TLS1_k127_5388339_2 ORF located using Blastx - - - 0.00000000021 64.0
TLS1_k127_5388339_3 - - - - 0.00001963 47.0
TLS1_k127_5389798_0 Transposase K07497 - - 0.00000000000000006574 93.0
TLS1_k127_5400780_0 COG0380 Trehalose-6-phosphate synthase K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000156 284.0
TLS1_k127_540444_0 Heat shock 70 kDa protein K04043 - - 0.0 1114.0
TLS1_k127_540444_1 guanyl-nucleotide exchange factor activity - - - 4.417e-210 668.0
TLS1_k127_540444_10 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000004893 214.0
TLS1_k127_540444_2 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 405.0
TLS1_k127_540444_3 Photosynthesis system II assembly factor YCF48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 357.0
TLS1_k127_540444_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 338.0
TLS1_k127_540444_5 phosphopentomutase activity K01839 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 312.0
TLS1_k127_540444_6 Quinolinate phosphoribosyl transferase, C-terminal domain K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002626 278.0
TLS1_k127_540444_7 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000001998 223.0
TLS1_k127_540444_8 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000000000000000000000000000001634 218.0
TLS1_k127_540444_9 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000000000000003018 209.0
TLS1_k127_5411546_0 DNA-directed DNA polymerase K02337,K14162 - 2.7.7.7 0.0 1267.0
TLS1_k127_5411546_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 1.084e-280 867.0
TLS1_k127_5411546_10 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 509.0
TLS1_k127_5411546_11 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 503.0
TLS1_k127_5411546_12 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 437.0
TLS1_k127_5411546_13 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 434.0
TLS1_k127_5411546_14 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 410.0
TLS1_k127_5411546_15 Metallopeptidase family M24 K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003732 394.0
TLS1_k127_5411546_16 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 392.0
TLS1_k127_5411546_17 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 362.0
TLS1_k127_5411546_18 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 351.0
TLS1_k127_5411546_19 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 331.0
TLS1_k127_5411546_2 (ABC) transporter K15738 - - 4.131e-271 846.0
TLS1_k127_5411546_20 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 314.0
TLS1_k127_5411546_21 signal-transduction protein containing cAMP-binding and CBS domains K02342,K05847,K07182 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 305.0
TLS1_k127_5411546_22 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008504 292.0
TLS1_k127_5411546_23 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 283.0
TLS1_k127_5411546_24 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001104 278.0
TLS1_k127_5411546_25 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009878 277.0
TLS1_k127_5411546_26 Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family K00569 - 2.1.1.67 0.000000000000000000000000000000000000000000000000000000000000000000000000000006378 266.0
TLS1_k127_5411546_27 Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005236 264.0
TLS1_k127_5411546_28 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001041 255.0
TLS1_k127_5411546_29 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001062 262.0
TLS1_k127_5411546_3 choline dehydrogenase activity K08261 - 1.1.99.21 1.129e-263 822.0
TLS1_k127_5411546_30 Fimbrial assembly protein (PilN) K02663 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001213 257.0
TLS1_k127_5411546_31 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004931 241.0
TLS1_k127_5411546_32 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000001338 237.0
TLS1_k127_5411546_33 HDOD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005927 231.0
TLS1_k127_5411546_34 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000000000000000000000779 221.0
TLS1_k127_5411546_35 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001078 221.0
TLS1_k127_5411546_36 - - - - 0.000000000000000000000000000000000000000000000000000000000000001146 228.0
TLS1_k127_5411546_37 Protein conserved in bacteria K11719 - - 0.0000000000000000000000000000000000000000000000000000000000001398 217.0
TLS1_k127_5411546_38 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000004807 203.0
TLS1_k127_5411546_39 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001811 200.0
TLS1_k127_5411546_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.224e-250 778.0
TLS1_k127_5411546_40 Pilus assembly protein, PilP K02665 - - 0.00000000000000000000000000000000000000000000000000000008451 203.0
TLS1_k127_5411546_41 Nitrogen regulatory protein P-II K04751,K04752 - - 0.00000000000000000000000000000000000000000000000000000009719 196.0
TLS1_k127_5411546_42 Gram-negative-bacterium-type cell outer membrane assembly K04064,K06186 GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896 - 0.0000000000000000000000000000000000000000000000000000001049 198.0
TLS1_k127_5411546_43 - - - - 0.0000000000000000000000000000000000000000000000000000131 192.0
TLS1_k127_5411546_44 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000000000000000003078 190.0
TLS1_k127_5411546_45 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000002417 179.0
TLS1_k127_5411546_46 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000005394 174.0
TLS1_k127_5411546_47 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000005353 171.0
TLS1_k127_5411546_48 - - - - 0.000000000000000000000000000000000000000000000076 177.0
TLS1_k127_5411546_49 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000000001657 161.0
TLS1_k127_5411546_5 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 1.424e-226 711.0
TLS1_k127_5411546_50 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000000000004365 166.0
TLS1_k127_5411546_51 OstA-like protein K09774 - - 0.000000000000000000000000000000000000004638 153.0
TLS1_k127_5411546_52 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000003475 137.0
TLS1_k127_5411546_53 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.00000000000000000000000000000000001869 135.0
TLS1_k127_5411546_54 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000404 138.0
TLS1_k127_5411546_55 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000004844 135.0
TLS1_k127_5411546_56 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000000000000001246 133.0
TLS1_k127_5411546_57 Periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000002141 115.0
TLS1_k127_5411546_58 30S ribosomal protein S14 K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000002081 111.0
TLS1_k127_5411546_59 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000008225 102.0
TLS1_k127_5411546_6 Secretin and TonB N terminus short domain K02666 - - 2.114e-209 671.0
TLS1_k127_5411546_60 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000001587 96.0
TLS1_k127_5411546_61 Domain of unknown function (DUF4403) - - - 0.00000000000000000002809 105.0
TLS1_k127_5411546_62 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000002917 86.0
TLS1_k127_5411546_63 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K11686,K13640,K18997 - - 0.00000000000000002447 83.0
TLS1_k127_5411546_64 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000007795 81.0
TLS1_k127_5411546_65 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000001725 78.0
TLS1_k127_5411546_66 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000005788 69.0
TLS1_k127_5411546_67 - - - - 0.0000000000006958 70.0
TLS1_k127_5411546_68 Glyoxalase-like domain - - - 0.0000001034 55.0
TLS1_k127_5411546_69 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000008682 53.0
TLS1_k127_5411546_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 563.0
TLS1_k127_5411546_70 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00002466 51.0
TLS1_k127_5411546_8 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 575.0
TLS1_k127_5411546_9 Fic/DOC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009148 517.0
TLS1_k127_5418454_1 - - - - 0.00000000000000000000002225 106.0
TLS1_k127_5421791_0 Chemotaxis protein methyltransferase K00575 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 434.0
TLS1_k127_5421791_1 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411,K03412 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000001168 261.0
TLS1_k127_5421791_2 UDP-4-amino-4-deoxy-L-arabinose aminotransferase K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000002305 173.0
TLS1_k127_5437385_0 - - - - 0.000000000000003832 91.0
TLS1_k127_5442237_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 1e-219 683.0
TLS1_k127_545027_0 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004714 259.0
TLS1_k127_545027_1 Transcriptional regulator - - - 0.0000000000000000000000005965 115.0
TLS1_k127_5455326_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 436.0
TLS1_k127_5455326_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003449 261.0
TLS1_k127_5455326_2 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001339 255.0
TLS1_k127_5455326_3 nitric oxide dioxygenase activity - - - 0.000000000000000000000000000000000000000000000000000000000003875 214.0
TLS1_k127_5463540_0 hemerythrin HHE cation binding domain - - - 0.00000000000000000000002326 108.0
TLS1_k127_5463540_1 modulation by symbiont of host adenylate cyclase-mediated signal transduction K03775 - 5.2.1.8 0.000000000000001006 86.0
TLS1_k127_5471783_0 electron transfer activity K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 535.0
TLS1_k127_5471783_1 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 375.0
TLS1_k127_5471783_2 YtkA-like - - - 0.00000000000000000000000000000000000000000000001389 175.0
TLS1_k127_5471783_3 YtkA-like - - - 0.00000000000000000000000000000000000000000000005639 173.0
TLS1_k127_5471783_4 - K01992 - - 0.000000000000000000000000000003889 130.0
TLS1_k127_5472571_0 - - - - 0.00000000000000000000000000000000000000004035 154.0
TLS1_k127_5472571_2 - - - - 0.0000000000000003401 80.0
TLS1_k127_5472571_3 - - - - 0.000000000002248 69.0
TLS1_k127_5472571_4 - - - - 0.00000000001137 65.0
TLS1_k127_5472571_5 - - - - 0.00000000001184 66.0
TLS1_k127_5472571_6 - - - - 0.0000000009356 60.0
TLS1_k127_5475172_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1604.0
TLS1_k127_5475172_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 582.0
TLS1_k127_5475172_10 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000000000000000000003711 227.0
TLS1_k127_5475172_11 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000001078 216.0
TLS1_k127_5475172_12 SprT-like family K02742 - - 0.0000000000000000000000000000000000000000000000005908 182.0
TLS1_k127_5475172_13 cellular response to DNA damage stimulus K07340 - - 0.00000000000000000000000000000000000000000000009239 175.0
TLS1_k127_5475172_14 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06991 - - 0.0000000000000000000000000000000000000000000009531 167.0
TLS1_k127_5475172_15 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000001578 163.0
TLS1_k127_5475172_16 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000001722 161.0
TLS1_k127_5475172_2 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 564.0
TLS1_k127_5475172_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006482 571.0
TLS1_k127_5475172_4 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002464 489.0
TLS1_k127_5475172_5 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 475.0
TLS1_k127_5475172_6 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007025 345.0
TLS1_k127_5475172_7 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 345.0
TLS1_k127_5475172_8 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 339.0
TLS1_k127_5475172_9 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 289.0
TLS1_k127_5486697_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 603.0
TLS1_k127_5491622_0 Serves to protect cells from the toxic effects of hydrogen peroxide K03781 - 1.11.1.6 1.57e-318 989.0
TLS1_k127_5491622_1 Glycosyl hydrolases family 15 - - - 1.583e-245 772.0
TLS1_k127_5491622_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001823 243.0
TLS1_k127_5491622_3 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000007161 246.0
TLS1_k127_5491622_4 GHKL domain - - - 0.000000000000000000000000000000000000000000000000000002899 218.0
TLS1_k127_5491622_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000001689 145.0
TLS1_k127_5491622_6 glutathione transferase activity K00799 - 2.5.1.18 0.0000000000145 69.0
TLS1_k127_5527046_0 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006678 278.0
TLS1_k127_5527046_2 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000003436 123.0
TLS1_k127_553990_0 tRNA thio-modification K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 530.0
TLS1_k127_553990_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 497.0
TLS1_k127_553990_2 lipopolysaccharide transport K22110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009188 462.0
TLS1_k127_553990_3 pectinesterase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 430.0
TLS1_k127_553990_4 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004826 271.0
TLS1_k127_5553972_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 496.0
TLS1_k127_5553972_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 457.0
TLS1_k127_5553972_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000001168 93.0
TLS1_k127_5560578_0 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 443.0
TLS1_k127_5560578_1 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000005084 196.0
TLS1_k127_5569414_0 B-1 B cell differentiation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 530.0
TLS1_k127_5569414_1 Peptidoglycan-synthase activator LpoB K07337 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 309.0
TLS1_k127_5569414_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009175 276.0
TLS1_k127_5580094_0 Transposase DDE domain - - - 5.321e-206 648.0
TLS1_k127_5580094_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000005937 176.0
TLS1_k127_5581532_0 TonB-dependent Receptor Plug Domain - - - 0.00000000000000000000000000000000000000000007115 176.0
TLS1_k127_5586579_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 546.0
TLS1_k127_5586579_1 obsolete transcription factor activity, core RNA polymerase II binding K06959 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 286.0
TLS1_k127_5586579_2 cysteine-type peptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000006206 213.0
TLS1_k127_5590435_0 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 554.0
TLS1_k127_5590435_1 Metalloenzyme superfamily K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007659 484.0
TLS1_k127_5590572_0 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 491.0
TLS1_k127_5590572_1 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000000000000000000000000002219 242.0
TLS1_k127_559787_0 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 460.0
TLS1_k127_559787_1 methyltransferase K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 327.0
TLS1_k127_559787_3 PFAM Integrase catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001003 284.0
TLS1_k127_5599983_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 3.956e-227 711.0
TLS1_k127_5599983_1 - - - - 0.0000000000000000122 92.0
TLS1_k127_5600278_0 Transposase DDE domain group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 563.0
TLS1_k127_5611451_0 lipopolysaccharide transport K22110 - - 0.0 1134.0
TLS1_k127_5611451_1 Glycogen debranching enzyme - - - 3.81e-277 866.0
TLS1_k127_5611451_2 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 390.0
TLS1_k127_5611451_3 - K11477 - - 0.000000000000000000000000000000000000000000000000000000000000000006054 230.0
TLS1_k127_5611451_5 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000002382 111.0
TLS1_k127_5611451_6 Dicarboxylate transport - - - 0.00000000000000000000000003533 126.0
TLS1_k127_5611451_7 protein conserved in bacteria K09978 - - 0.00000000000000000004086 93.0
TLS1_k127_5611451_8 YnbE-like lipoprotein - - - 0.0000000000000002567 80.0
TLS1_k127_5615414_0 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000005178 246.0
TLS1_k127_5615414_1 PRC-barrel domain - - - 0.000000000002345 70.0
TLS1_k127_5615414_2 UPF0391 membrane protein - - - 0.000005206 49.0
TLS1_k127_5637528_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 1.128e-317 976.0
TLS1_k127_5637528_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 2.952e-316 994.0
TLS1_k127_5637528_11 Protein of unknown function (DUF1328) - - - 0.00000000008849 63.0
TLS1_k127_5637528_12 Belongs to the UPF0337 (CsbD) family - - - 0.0000000003294 63.0
TLS1_k127_5637528_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 615.0
TLS1_k127_5637528_3 Transcriptional regulator, Crp Fnr family - - - 0.0000000000000000000000000000000000000000000000000000000000000002031 229.0
TLS1_k127_5637528_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000000000005503 219.0
TLS1_k127_5637528_5 Plasmid pRiA4b ORF-3-like protein - - - 0.0000000000000000000000000008672 114.0
TLS1_k127_5637528_6 peptidase - - - 0.0000000000000000001378 93.0
TLS1_k127_5637528_7 Rieske [2Fe-2S] domain - - - 0.000000000000000005701 84.0
TLS1_k127_5637528_8 Protein of unknown function (DUF3309) - - - 0.00000000000000001964 82.0
TLS1_k127_5637528_9 - - - - 0.000000000000001155 79.0
TLS1_k127_5637644_0 Transposase IS116 IS110 IS902 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 496.0
TLS1_k127_5637644_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000001117 108.0
TLS1_k127_5641058_0 - - - - 0.00000000000000000002029 92.0
TLS1_k127_5641058_1 - - - - 0.000000000000000001419 88.0
TLS1_k127_5641058_4 the current gene model (or a revised gene model) may contain one or more premature stops and or frameshifts - - - 0.0000001686 54.0
TLS1_k127_5641985_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 586.0
TLS1_k127_5641985_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004226 435.0
TLS1_k127_5641985_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 287.0
TLS1_k127_5641985_3 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000004005 217.0
TLS1_k127_5643074_0 PFAM transposase IS4 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008176 260.0
TLS1_k127_5644337_0 Evidence 4 Homologs of previously reported genes of K18912 - 1.14.99.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 570.0
TLS1_k127_5644337_1 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000005122 237.0
TLS1_k127_5646879_0 Transposase IS66 family K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004067 273.0
TLS1_k127_5646879_1 PFAM IS66 Orf2 like protein K07484 - - 0.0000000000000000000000001969 115.0
TLS1_k127_5648406_0 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002438 321.0
TLS1_k127_5648406_1 Fic/DOC family N-terminal - - - 0.000000000000000000000000000000000000000000005407 166.0
TLS1_k127_5648406_2 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000006734 160.0
TLS1_k127_5648406_3 Ketosteroid isomerase-related protein - - - 0.00000000000000000000005942 103.0
TLS1_k127_5648406_4 Belongs to the 'phage' integrase family - - - 0.0007497 46.0
TLS1_k127_5652702_0 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 3.727e-202 644.0
TLS1_k127_5652702_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 4.198e-196 619.0
TLS1_k127_5652702_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 496.0
TLS1_k127_5652702_3 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 364.0
TLS1_k127_5652702_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000004679 226.0
TLS1_k127_5652702_5 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000000000001627 179.0
TLS1_k127_5652702_6 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000000000000003423 174.0
TLS1_k127_5652702_7 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000007075 156.0
TLS1_k127_5652702_8 protein secretion K03116,K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000005926 138.0
TLS1_k127_5652702_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000000000000000001106 106.0
TLS1_k127_5665124_0 Transposase K07494 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001168 278.0
TLS1_k127_5715083_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 8.288e-320 997.0
TLS1_k127_5715083_1 Lysine-2,3-aminomutase K01843 - 5.4.3.2 1.372e-209 657.0
TLS1_k127_5715083_2 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 1.716e-199 627.0
TLS1_k127_5715083_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 587.0
TLS1_k127_5715083_4 Associated with various cellular activities K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 441.0
TLS1_k127_5715083_5 Uncharacterised conserved protein (DUF2156) K01163,K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 438.0
TLS1_k127_5715083_6 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.000000000000000000000000000000000000000000000000000000000000000000000006552 251.0
TLS1_k127_5715083_8 glutathione transferase activity K00799 - 2.5.1.18 0.00000000000000000000000000006685 119.0
TLS1_k127_5715083_9 DUF167 K09131 - - 0.00000000000000000001644 95.0
TLS1_k127_5735155_0 Helix-turn-helix domain of transposase family ISL3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 361.0
TLS1_k127_5735155_1 KaiC K08482 - - 0.0000000000000000000000003577 108.0
TLS1_k127_5735155_2 PFAM Circadian clock protein KaiC central region K08482 - - 0.000001995 50.0
TLS1_k127_5739459_0 transposition K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 419.0
TLS1_k127_5739459_1 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000654 264.0
TLS1_k127_5739459_2 Fibronectin type III-like domain K05349 - 3.2.1.21 0.00000000000009586 71.0
TLS1_k127_5746727_0 required for the transposition of insertion element IS2404 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009389 278.0
TLS1_k127_5746727_2 - - - - 0.000000002124 62.0
TLS1_k127_574683_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 556.0
TLS1_k127_574683_1 peptide catabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000003133 234.0
TLS1_k127_574683_2 PAP2 superfamily K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000001462 200.0
TLS1_k127_574683_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00001383 49.0
TLS1_k127_5747900_0 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 2.893e-216 685.0
TLS1_k127_5747900_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 362.0
TLS1_k127_5747900_2 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001373 256.0
TLS1_k127_5747900_3 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000003785 200.0
TLS1_k127_5747900_4 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000004696 192.0
TLS1_k127_5747900_5 Sulphur transport K07112 - - 0.00000000000000000000000000000000002836 143.0
TLS1_k127_5787667_0 SMART Metal-dependent phosphohydrolase, HD region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 291.0
TLS1_k127_5787667_1 COG2206 HD-GYP domain - - - 0.00000004642 60.0
TLS1_k127_5790441_0 TonB-dependent receptor K02014 - - 5.362e-220 702.0
TLS1_k127_5790444_0 PFAM Integrase catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 385.0
TLS1_k127_5790444_1 IstB-like ATP binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006921 250.0
TLS1_k127_5827551_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002505 342.0
TLS1_k127_5827551_1 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 302.0
TLS1_k127_5827551_2 nitric oxide reductase activity K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000387 229.0
TLS1_k127_5827551_3 Domain of unknown function (DUF5069) - - - 0.00000000000000000000000000000000000000000000000000000000005092 215.0
TLS1_k127_5827551_4 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000003405 203.0
TLS1_k127_5827551_5 Regulatory protein, FmdB family - - - 0.0000000000000000000000000006682 120.0
TLS1_k127_5827551_7 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 - 0.00000000000000000000000003727 110.0
TLS1_k127_5835885_0 Glycoside Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002067 267.0
TLS1_k127_5835885_1 protein conserved in bacteria - - - 0.00000000000000000000000000008758 118.0
TLS1_k127_5842772_0 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004248 422.0
TLS1_k127_5842772_1 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.000000000000000000000099 99.0
TLS1_k127_5853889_0 protein conserved in bacteria K09859 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 562.0
TLS1_k127_5853889_1 LPP20 lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 383.0
TLS1_k127_5853889_2 mannosylglycerate metabolic process K05947,K07026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001671 286.0
TLS1_k127_5853889_3 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000003879 263.0
TLS1_k127_5853889_4 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002 258.0
TLS1_k127_5853889_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003112 243.0
TLS1_k127_5853889_6 Peptidoglycan-synthase activator LpoB K07337 - - 0.000000000000008823 74.0
TLS1_k127_5860190_0 MULE transposase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 549.0
TLS1_k127_5866735_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0 1381.0
TLS1_k127_5866735_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.972e-196 620.0
TLS1_k127_5866735_11 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 289.0
TLS1_k127_5866735_13 PFAM Bacterial domain of - - - 0.000000000000000000000000000000000000000000000001165 196.0
TLS1_k127_5866735_14 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000000000000000000000000000003858 169.0
TLS1_k127_5866735_16 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000001872 153.0
TLS1_k127_5866735_18 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000000000000000000000000000005354 140.0
TLS1_k127_5866735_19 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078,K05553 - - 0.000000000000000000000000022 114.0
TLS1_k127_5866735_2 A circularly permuted ATPgrasp - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 603.0
TLS1_k127_5866735_20 - - - - 0.000000000000000000000648 102.0
TLS1_k127_5866735_22 YaeQ - - - 0.0000001525 54.0
TLS1_k127_5866735_23 HD domain - - - 0.0001623 49.0
TLS1_k127_5866735_3 dicarboxylic acid transport K03309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 580.0
TLS1_k127_5866735_4 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 568.0
TLS1_k127_5866735_5 converts alpha-aldose to the beta-anomer K01785 GO:0003674,GO:0003824,GO:0004034,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006006,GO:0006012,GO:0006082,GO:0006790,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016853,GO:0016854,GO:0016857,GO:0019318,GO:0019320,GO:0019388,GO:0033499,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1902776,GO:1902777 5.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 486.0
TLS1_k127_5866735_6 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 476.0
TLS1_k127_5866735_7 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 445.0
TLS1_k127_5866735_8 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 434.0
TLS1_k127_5866735_9 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 388.0
TLS1_k127_586706_0 metallopeptidase activity K06212,K06402 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 292.0
TLS1_k127_5886275_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 5.834e-249 770.0
TLS1_k127_590091_0 mature ribosome assembly K14574 - - 0.00002496 49.0
TLS1_k127_5932995_0 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 412.0
TLS1_k127_5932995_1 Protein of unknown function (DUF3422) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 419.0
TLS1_k127_5932995_2 thiosulfate sulfurtransferase activity K01011,K21028 - 2.8.1.1,2.8.1.11,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009221 322.0
TLS1_k127_5932995_3 ribonucleoside-diphosphate reductase activity K07735 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 297.0
TLS1_k127_5932995_4 Small metal-binding protein - - - 0.0000000009172 68.0
TLS1_k127_5932995_5 - - - - 0.000000002122 60.0
TLS1_k127_5938226_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 315.0
TLS1_k127_5938226_1 RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000000183 163.0
TLS1_k127_5938226_2 Sigma-70 region 2 K03088 - - 0.00000000000001146 74.0
TLS1_k127_5938226_3 Putative zinc-finger - - - 0.0000001424 58.0
TLS1_k127_594474_0 phosphoesterase, PA-phosphatase related - - - 0.000000000000000000000000000000000000000000000000000000008644 199.0
TLS1_k127_594474_1 alcohol dehydrogenase K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000001014 166.0
TLS1_k127_594474_2 transposition - - - 0.00000000008993 74.0
TLS1_k127_5998076_0 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 457.0
TLS1_k127_5998076_1 cobalamin synthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 415.0
TLS1_k127_5998076_2 Protein of unknown function (DUF2971) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007561 268.0
TLS1_k127_5998076_3 translation initiation factor activity K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000004757 179.0
TLS1_k127_5998076_4 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.000000000000000000000000000000000000000352 151.0
TLS1_k127_5998076_5 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000000000000000805 128.0
TLS1_k127_6072498_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 1.369e-304 962.0
TLS1_k127_6072498_1 belongs to the aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 1.167e-241 755.0
TLS1_k127_6072498_10 Animal haem peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 494.0
TLS1_k127_6072498_11 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 436.0
TLS1_k127_6072498_12 aldo-keto reductase (NADP) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 427.0
TLS1_k127_6072498_13 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 394.0
TLS1_k127_6072498_14 Inorganic pyrophosphatase K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 363.0
TLS1_k127_6072498_15 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00350 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 330.0
TLS1_k127_6072498_16 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00349 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 321.0
TLS1_k127_6072498_17 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 307.0
TLS1_k127_6072498_18 lactoylglutathione lyase activity K08234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 304.0
TLS1_k127_6072498_19 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000003936 249.0
TLS1_k127_6072498_2 Oxidoreductase FAD-binding domain - - - 4.224e-209 656.0
TLS1_k127_6072498_20 lactoylglutathione lyase activity K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000002304 219.0
TLS1_k127_6072498_21 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000009677 215.0
TLS1_k127_6072498_23 - - - - 0.00000000000000000000000000000000000000000000000002775 181.0
TLS1_k127_6072498_25 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000001788 148.0
TLS1_k127_6072498_26 (Na+)-NQR maturation NqrM K05952 - - 0.00000000000001017 76.0
TLS1_k127_6072498_27 - - - - 0.0000000001505 65.0
TLS1_k127_6072498_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00347 - 1.6.5.8 9.059e-209 654.0
TLS1_k127_6072498_4 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 - 1.6.5.8 1.175e-206 652.0
TLS1_k127_6072498_5 saccharopine dehydrogenase activity K00290 - 1.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 558.0
TLS1_k127_6072498_6 HI0933 family K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 550.0
TLS1_k127_6072498_7 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 521.0
TLS1_k127_6072498_8 sequence-specific DNA binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 508.0
TLS1_k127_6072498_9 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 527.0
TLS1_k127_6074720_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1712.0
TLS1_k127_6074720_1 chaperone-mediated protein folding - - - 0.0000000000000000000000002227 106.0
TLS1_k127_6074720_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000001531 74.0
TLS1_k127_6078155_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 510.0
TLS1_k127_6078155_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 314.0
TLS1_k127_6078155_2 - - - - 0.000000000000000000000000004128 110.0
TLS1_k127_6078155_3 transposition K07497 - - 0.000001026 50.0
TLS1_k127_6079042_0 ABC-2 family transporter protein K01992 - - 0.0 1137.0
TLS1_k127_6079042_1 TonB-dependent receptor - - - 0.0 1062.0
TLS1_k127_6079042_10 HupE / UreJ protein - - - 0.0000000000000000000006735 99.0
TLS1_k127_6079042_11 Hsp20/alpha crystallin family K13993 - - 0.00000000000000246 81.0
TLS1_k127_6079042_2 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 7.882e-251 787.0
TLS1_k127_6079042_3 smart pdz dhr glgf K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 443.0
TLS1_k127_6079042_4 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 382.0
TLS1_k127_6079042_5 Domain of unknown function (DUF4340) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001268 288.0
TLS1_k127_6079042_6 Belongs to the DNA glycosylase MPG family K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001189 277.0
TLS1_k127_6079042_7 response to nickel cation K07722 GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016151,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032991,GO:0032993,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071840,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000001183 229.0
TLS1_k127_6079042_9 Domain of unknown function (DUF3842) - - - 0.0000000000000000000000000000000004998 135.0
TLS1_k127_6093689_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 576.0
TLS1_k127_6093689_1 methyltransferase K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 543.0
TLS1_k127_6093689_2 stress-induced mitochondrial fusion K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 534.0
TLS1_k127_6093689_3 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009923 498.0
TLS1_k127_6093689_4 stress-induced mitochondrial fusion K04087 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000006777 218.0
TLS1_k127_6093689_5 DNA-binding transcription factor activity K03892 - - 0.00000000000000000000000000000000000000000000005109 171.0
TLS1_k127_6099363_0 protein secretion by the type I secretion system K11004 - - 0.0 1074.0
TLS1_k127_6099363_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02022,K11003,K12532 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 604.0
TLS1_k127_6099363_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 437.0
TLS1_k127_6099363_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000891 94.0
TLS1_k127_6101126_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.33e-322 995.0
TLS1_k127_6101126_1 peptidyl-lysine modification to peptidyl-hypusine K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 590.0
TLS1_k127_6101126_2 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 299.0
TLS1_k127_6103874_0 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 496.0
TLS1_k127_6103874_1 Evidence 5 No homology to any previously reported sequences K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 383.0
TLS1_k127_6103874_2 Replication initiation factor K07467 - - 0.00000000000000000000000000000000000000000000000000000000000005048 220.0
TLS1_k127_6103874_3 DNA excision K02806 - - 0.00000000000000000000000000001439 121.0
TLS1_k127_6103874_4 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0003881 44.0
TLS1_k127_6107839_0 strictosidine synthase activity - - - 0.0 1784.0
TLS1_k127_6107839_1 ATHILA ORF-1 family - - - 0.0000000000000003668 92.0
TLS1_k127_6114267_0 radical SAM domain protein - - - 0.0 1007.0
TLS1_k127_6114267_1 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001016 264.0
TLS1_k127_6114267_10 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain' K04771 GO:0008150,GO:0009266,GO:0009628,GO:0050896 3.4.21.107 0.0000826 55.0
TLS1_k127_6114267_2 pterin-4-alpha-carbinolamine dehydratase K01724 GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 0.000000000000000000000000000000000000000000000000000000000000004591 221.0
TLS1_k127_6114267_3 peroxiredoxin activity K00627,K01607 - 2.3.1.12,4.1.1.44 0.000000000000000000000000000000000000000000000000000001252 194.0
TLS1_k127_6114267_4 TIR domain - - - 0.000000000000000000000001567 119.0
TLS1_k127_6114267_6 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000005025 81.0
TLS1_k127_6114267_7 - K21495 - - 0.00000000000002105 76.0
TLS1_k127_6114267_8 chromosome segregation K03497 - - 0.00000000000006027 73.0
TLS1_k127_6114267_9 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000008761 84.0
TLS1_k127_6116462_0 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 1.227e-320 1005.0
TLS1_k127_6116462_1 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 304.0
TLS1_k127_6116462_2 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000002732 190.0
TLS1_k127_6116462_3 - - - - 0.0000000000000000000000000000000000000000000000009742 183.0
TLS1_k127_6116462_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000002494 175.0
TLS1_k127_6125416_0 short chain amide porin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 354.0
TLS1_k127_6147014_0 PFAM Citrate transporter - - - 1.159e-195 619.0
TLS1_k127_6147014_1 Uncharacterized conserved protein (DUF2294) - - - 0.0000000000000000000000000000000000000000000007399 169.0
TLS1_k127_6155364_0 Multicopper oxidase K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.0 3108.0
TLS1_k127_6155364_1 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 456.0
TLS1_k127_6155364_2 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000001836 209.0
TLS1_k127_6163720_0 Dehydratase family K01687 - 4.2.1.9 7.853e-261 809.0
TLS1_k127_6163720_1 serine-type endopeptidase activity K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 615.0
TLS1_k127_6163720_2 Elongation factor G, domain IV K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 595.0
TLS1_k127_6163720_3 PP-loop family K21947 - 2.8.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 486.0
TLS1_k127_6163720_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 424.0
TLS1_k127_6163720_5 ATP-independent chaperone mediated protein folding - - - 0.0000000000000000000000000000000000000000000000000000002843 201.0
TLS1_k127_6163720_6 domain protein K10716 - - 0.0000000000000000000000000000000000000897 151.0
TLS1_k127_6171374_1 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 0.0000000000000000000000000000000000000000000000000000000000000000003278 232.0
TLS1_k127_6171374_2 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000404 223.0
TLS1_k127_6178999_0 - - - - 1.088e-270 839.0
TLS1_k127_6178999_1 tungstate binding K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000003832 238.0
TLS1_k127_6193846_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.00002297 59.0
TLS1_k127_6194992_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K12953 GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000007527 216.0
TLS1_k127_6194992_1 signal-transduction protein containing cAMP-binding and CBS domains K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000003935 167.0
TLS1_k127_6194992_2 membrane - - - 0.0000000000000000000000000000000000000000005233 163.0
TLS1_k127_6194992_3 universal stress protein - - - 0.00000000000000001078 89.0
TLS1_k127_6194992_4 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000003259 71.0
TLS1_k127_6194992_5 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000002023 65.0
TLS1_k127_6194992_6 - - - - 0.0000002354 59.0
TLS1_k127_6204684_0 PFAM Mo-dependent nitrogenase K00232 - 1.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 475.0
TLS1_k127_6204684_1 transcription factor binding K02584,K12146,K12266,K15836,K21009 GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007068 395.0
TLS1_k127_6204684_2 Methyltransferase domain - - - 0.00000000000000000000000000000000002009 141.0
TLS1_k127_6213097_0 strictosidine synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 321.0
TLS1_k127_6231911_0 Molydopterin dinucleotide binding domain K00302,K10814 - 1.4.99.5,1.5.3.1 0.0 1416.0
TLS1_k127_6231911_1 NADH-quinone oxidoreductase K00341,K05568,K12139 - 1.6.5.3 0.0 1027.0
TLS1_k127_6231911_10 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 408.0
TLS1_k127_6231911_11 Flagellar Motor Protein K02557 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 396.0
TLS1_k127_6231911_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 351.0
TLS1_k127_6231911_13 Protein of unknown function (DUF1365) K00574,K09701 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 353.0
TLS1_k127_6231911_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 331.0
TLS1_k127_6231911_15 Phosphodiester glycosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 298.0
TLS1_k127_6231911_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 285.0
TLS1_k127_6231911_17 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005974 259.0
TLS1_k127_6231911_18 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000535 256.0
TLS1_k127_6231911_19 Outer Membrane Lipoprotein K03098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007249 250.0
TLS1_k127_6231911_2 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342,K05575 - 1.6.5.3 5.76e-298 921.0
TLS1_k127_6231911_20 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000002791 244.0
TLS1_k127_6231911_21 NADH dehydrogenase (ubiquinone) activity K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000149 222.0
TLS1_k127_6231911_22 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000000000001265 166.0
TLS1_k127_6231911_23 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000004587 146.0
TLS1_k127_6231911_24 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000000000000001754 142.0
TLS1_k127_6231911_25 phosphorelay signal transduction system - - - 0.000000000000000000000000000001178 123.0
TLS1_k127_6231911_28 oxidoreductase activity, acting on the CH-CH group of donors - - - 0.0000000000003424 70.0
TLS1_k127_6231911_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 1.354e-263 812.0
TLS1_k127_6231911_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 1.307e-257 802.0
TLS1_k127_6231911_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 2.868e-250 780.0
TLS1_k127_6231911_6 Flavin containing amine oxidoreductase K06954 - - 4.167e-198 624.0
TLS1_k127_6231911_7 CHASE3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 550.0
TLS1_k127_6231911_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 545.0
TLS1_k127_6231911_9 cyclopropane-fatty-acyl-phospholipid synthase K00574,K20238 - 2.1.1.317,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 537.0
TLS1_k127_6238470_0 Uncharacterized protein family (UPF0051) K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 546.0
TLS1_k127_6238470_1 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006097 540.0
TLS1_k127_6238470_10 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.00000001377 61.0
TLS1_k127_6238470_11 - - - - 0.000004945 58.0
TLS1_k127_6238470_2 BON domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004816 259.0
TLS1_k127_6238470_3 PFAM ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000002322 231.0
TLS1_k127_6238470_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000004237 132.0
TLS1_k127_6238470_5 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.000000000000000000000000009695 119.0
TLS1_k127_6238470_6 Dodecin K09165 - - 0.000000000000000000002878 94.0
TLS1_k127_6238470_7 Protein of unknown function (DUF2459) - - - 0.000000000000004839 84.0
TLS1_k127_6238470_8 PFAM ATP-binding region ATPase domain protein - - - 0.000000000005164 75.0
TLS1_k127_6238470_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000006023 67.0
TLS1_k127_6253544_0 Dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 314.0
TLS1_k127_6253544_1 PFAM Cobyrinic acid ac-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002364 256.0
TLS1_k127_6253544_2 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000005813 193.0
TLS1_k127_6253544_3 - - - - 0.00000000000000000000000000000000121 142.0
TLS1_k127_6278991_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.0 1259.0
TLS1_k127_6278991_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 2.683e-321 989.0
TLS1_k127_6278991_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 1.048e-249 774.0
TLS1_k127_6278991_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 592.0
TLS1_k127_6278991_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 362.0
TLS1_k127_6278991_5 2 iron, 2 sulfur cluster binding K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 300.0
TLS1_k127_6278991_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002219 268.0
TLS1_k127_6282301_0 ester cyclase - - - 0.000000000478 66.0
TLS1_k127_6288268_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 8.4e-323 992.0
TLS1_k127_6288268_1 glutamate dehydrogenase [NAD(P)+] activity K00261,K00262 - 1.4.1.3,1.4.1.4 2.05e-224 700.0
TLS1_k127_6288268_11 bacterial (prokaryotic) histone like domain K05788 - - 0.000000000000000000000000000000000000000000000001265 175.0
TLS1_k127_6288268_2 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 584.0
TLS1_k127_6288268_3 Proto-chlorophyllide reductase 57 kD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 497.0
TLS1_k127_6288268_4 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 434.0
TLS1_k127_6288268_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 419.0
TLS1_k127_6288268_6 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 372.0
TLS1_k127_6288268_7 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001249 273.0
TLS1_k127_6288268_9 lipoyl(octanoyl) transferase activity K03644,K03801 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181,2.8.1.8 0.0000000000000000000000000000000000000000000000000003478 194.0
TLS1_k127_631379_0 helicase activity K03579 - 3.6.4.13 2.747e-317 993.0
TLS1_k127_631379_1 helicase activity K05592 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0032574,GO:0032575,GO:0033554,GO:0033592,GO:0034057,GO:0034248,GO:0034250,GO:0034458,GO:0034459,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 2.184e-256 805.0
TLS1_k127_631379_11 Ribulose bisphosphate carboxylase large chain, catalytic domain K01601 - 4.1.1.39 0.00000000000000000005836 94.0
TLS1_k127_631379_12 Protein of unknown function (DUF1232) - - - 0.0000000000000000003739 93.0
TLS1_k127_631379_14 ribulose- bisphosphate carboxylase large chain K01601 - 4.1.1.39 0.000000009909 60.0
TLS1_k127_631379_15 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0006253 47.0
TLS1_k127_631379_2 iron-nicotianamine transmembrane transporter activity - GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - 1.559e-251 792.0
TLS1_k127_631379_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007338 587.0
TLS1_k127_631379_4 protoporphyrinogen oxidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 528.0
TLS1_k127_631379_5 Histidine kinase-like ATPase domain K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008009 338.0
TLS1_k127_631379_6 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 313.0
TLS1_k127_631379_7 Peptidase membrane zinc metallopeptidase K06973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005306 270.0
TLS1_k127_631379_8 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000009087 149.0
TLS1_k127_631379_9 Integral membrane protein TerC family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000004793 108.0
TLS1_k127_6329203_0 silver ion transport K15726 - - 0.0 1085.0
TLS1_k127_6329203_1 Cytochrome c K12263 - - 0.00000000000000000000000000001201 124.0
TLS1_k127_6339115_0 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit B K10945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 422.0
TLS1_k127_6339115_1 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit A K10944 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.14.18.3,1.14.99.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 378.0
TLS1_k127_6339115_2 PFAM Ammonia monooxygenase particulate methane monooxygenase, subunit C K10946 - - 0.0003328 44.0
TLS1_k127_6348791_0 chemotaxis protein K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005469 601.0
TLS1_k127_6348791_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 586.0
TLS1_k127_6348791_10 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001247 251.0
TLS1_k127_6348791_11 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000001943 210.0
TLS1_k127_6348791_12 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000002664 237.0
TLS1_k127_6348791_13 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000002904 187.0
TLS1_k127_6348791_15 phosphorelay signal transduction system K07714 - - 0.000000000000000000000000000000000000000000000000001153 192.0
TLS1_k127_6348791_16 Chemotaxis phosphatase, CheZ K03414 - - 0.00000000000000000000000000000000000000002089 160.0
TLS1_k127_6348791_17 Flagellar protein FliS K02422 - - 0.000000000000000000000000000000000000004209 150.0
TLS1_k127_6348791_19 protein histidine kinase activity - - - 0.000000000000000000000000007037 130.0
TLS1_k127_6348791_2 methyl-accepting chemotaxis protein (MCP) K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 567.0
TLS1_k127_6348791_20 DNA excision K02806 - - 0.0000000000000000000000000141 110.0
TLS1_k127_6348791_21 TIGRFAM Diguanylate cyclase - - - 0.00000000000000000000000005204 121.0
TLS1_k127_6348791_22 flagellar protein FlaG K06603 - - 0.00000000000000000005493 93.0
TLS1_k127_6348791_24 transmembrane signaling receptor activity K03406 - - 0.000001271 57.0
TLS1_k127_6348791_3 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006696 473.0
TLS1_k127_6348791_4 MotA/TolQ/ExbB proton channel family K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004029 407.0
TLS1_k127_6348791_5 bacterial-type flagellum organization K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 389.0
TLS1_k127_6348791_6 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 366.0
TLS1_k127_6348791_7 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008028 382.0
TLS1_k127_6348791_8 Membrane MotB of proton-channel complex MotA/MotB K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 295.0
TLS1_k127_6348791_9 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K03408 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001188 269.0
TLS1_k127_6354293_0 alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 417.0
TLS1_k127_6354293_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000002593 217.0
TLS1_k127_6354293_2 - - - - 0.000000000000000000000000000000000000000000000000005315 188.0
TLS1_k127_6354293_3 response regulator - - - 0.000000000000000000000000000000000000000009608 177.0
TLS1_k127_6354293_4 YceI-like domain - - - 0.000000000000001897 76.0
TLS1_k127_6354706_0 phosphorelay sensor kinase activity K02668 - 2.7.13.3 8.21e-247 774.0
TLS1_k127_6354706_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 6.135e-245 764.0
TLS1_k127_6354706_10 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 529.0
TLS1_k127_6354706_11 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000884 527.0
TLS1_k127_6354706_12 response regulator K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 508.0
TLS1_k127_6354706_13 Cell cycle protein K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 497.0
TLS1_k127_6354706_14 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 461.0
TLS1_k127_6354706_15 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 434.0
TLS1_k127_6354706_16 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 409.0
TLS1_k127_6354706_17 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009975 394.0
TLS1_k127_6354706_18 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005434 394.0
TLS1_k127_6354706_2 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 3.587e-233 734.0
TLS1_k127_6354706_20 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 323.0
TLS1_k127_6354706_21 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 317.0
TLS1_k127_6354706_22 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 309.0
TLS1_k127_6354706_23 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 294.0
TLS1_k127_6354706_24 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 287.0
TLS1_k127_6354706_25 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002583 275.0
TLS1_k127_6354706_26 Protein of unknown function (DUF520) K09767 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004064 263.0
TLS1_k127_6354706_27 protein transport across the cell outer membrane K02453,K03219 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007045 258.0
TLS1_k127_6354706_28 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000000000000000000000000000000000000000000000009411 240.0
TLS1_k127_6354706_29 DivIVA protein K04074 - - 0.00000000000000000000000000000000000000000000000000000000001277 211.0
TLS1_k127_6354706_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 6.28e-213 667.0
TLS1_k127_6354706_30 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.00000000000000000000000000000000000000000000000000000007559 200.0
TLS1_k127_6354706_31 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K01921,K03589,K06438 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 0.0000000000000000000000000000000000000000000003051 178.0
TLS1_k127_6354706_33 YGGT family K02221 - - 0.0000000000000000000000000000000006604 136.0
TLS1_k127_6354706_35 Evidence 5 No homology to any previously reported sequences - - - 0.00000000000000000000002184 104.0
TLS1_k127_6354706_4 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.694e-198 631.0
TLS1_k127_6354706_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 2.273e-197 618.0
TLS1_k127_6354706_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 3.78e-197 621.0
TLS1_k127_6354706_7 Type II secretion system (T2SS), protein F K02455,K02653 - - 5.034e-195 616.0
TLS1_k127_6354706_8 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 591.0
TLS1_k127_6354706_9 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 575.0
TLS1_k127_6381338_0 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 1.712e-205 643.0
TLS1_k127_6381338_3 arsenate reductase (glutaredoxin) activity K00537 - 1.20.4.1 0.00000000000000003081 82.0
TLS1_k127_6381338_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000002114 52.0
TLS1_k127_639228_0 ATPase activity K01990,K09697 - 3.6.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 442.0
TLS1_k127_639228_1 - K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 371.0
TLS1_k127_639228_2 - K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 329.0
TLS1_k127_6395315_0 peptide-methionine (S)-S-oxide reductase activity K07304,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001252 280.0
TLS1_k127_6395315_1 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000001564 222.0
TLS1_k127_641510_0 LAGLIDADG endonuclease - - - 0.0000000000000000000000000000000000000000000000000000002488 199.0
TLS1_k127_641510_1 - - - - 0.000000000000007323 76.0
TLS1_k127_6417599_0 COG0659 Sulfate permease and related transporters (MFS K01673,K03321 - 4.2.1.1 1.462e-297 931.0
TLS1_k127_6417599_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 9.439e-223 696.0
TLS1_k127_6417599_2 drug transmembrane transporter activity K03327 - - 3.406e-215 674.0
TLS1_k127_6417599_3 - K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 597.0
TLS1_k127_6417599_4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 426.0
TLS1_k127_6417599_5 Belongs to the sirtuin family. Class K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 379.0
TLS1_k127_6417599_6 Response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001718 280.0
TLS1_k127_6417599_7 Carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000419 240.0
TLS1_k127_6417599_8 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.0000000000000000000000000000000000000000000004076 175.0
TLS1_k127_6417599_9 - - - - 0.00000000000000000000000000000000000000007938 161.0
TLS1_k127_6425460_0 Chase2 domain K01768,K07315 - 3.1.3.3,4.6.1.1 9.781e-246 786.0
TLS1_k127_6425460_1 Evidence 5 No homology to any previously reported sequences K02450,K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000211 291.0
TLS1_k127_6425460_2 bis(5'-adenosyl)-triphosphatase activity - - - 0.00000000000000000000000000000000000000000000000135 181.0
TLS1_k127_6425460_4 Protein of unknown function (DUF3574) - - - 0.00000000000000000000000000000002111 130.0
TLS1_k127_6425595_0 Phosphate acyltransferases K01897,K05939 - 2.3.1.40,6.2.1.20,6.2.1.3 0.0 1110.0
TLS1_k127_6425595_1 mismatched DNA binding K03555 - - 0.000000000000000000000000000000000000005622 147.0
TLS1_k127_6457016_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000002124 53.0
TLS1_k127_6466296_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K19585 - - 0.0 1527.0
TLS1_k127_6466296_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 559.0
TLS1_k127_6466296_10 Iron-binding zinc finger CDGSH type - - - 0.0000000000000000000000000000000000277 135.0
TLS1_k127_6466296_2 Sodium/hydrogen exchanger family K11105 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 541.0
TLS1_k127_6466296_3 Sigma-54 interaction domain K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000343 520.0
TLS1_k127_6466296_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 492.0
TLS1_k127_6466296_5 Major facilitator Superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006939 484.0
TLS1_k127_6466296_6 electron transfer activity K03616 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004735 397.0
TLS1_k127_6466296_7 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005009 348.0
TLS1_k127_6466296_8 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K00567,K01247 - 2.1.1.63,3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003774 304.0
TLS1_k127_6466296_9 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001596 269.0
TLS1_k127_6478941_0 Winged helix-turn helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 299.0
TLS1_k127_6478941_1 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000004928 164.0
TLS1_k127_6478941_2 - - - - 0.0000000000005695 70.0
TLS1_k127_6478941_3 - - - - 0.0003641 43.0
TLS1_k127_6494559_0 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 536.0
TLS1_k127_6494559_1 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 361.0
TLS1_k127_6494559_2 Belongs to the pseudouridine synthase RsuA family K06178,K06181,K06182 - 5.4.99.20,5.4.99.21,5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 343.0
TLS1_k127_6494559_3 arginine decarboxylase activity K02626 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 336.0
TLS1_k127_6494559_4 Transcriptional regulator K03717 - - 0.0000000000000000000001615 98.0
TLS1_k127_6507082_1 - - - - 0.00000000000000003524 81.0
TLS1_k127_6507082_2 - - - - 0.0000000009142 63.0
TLS1_k127_6507082_4 - - - - 0.00000006579 54.0
TLS1_k127_6511532_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 2022.0
TLS1_k127_6511532_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 1.069e-293 917.0
TLS1_k127_6511532_10 DNA replication proofreading K02336,K06877,K07501 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 378.0
TLS1_k127_6511532_11 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000004895 263.0
TLS1_k127_6511532_12 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001551 259.0
TLS1_k127_6511532_13 GDP-mannose mannosyl hydrolase activity K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000702 255.0
TLS1_k127_6511532_14 ACT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002626 222.0
TLS1_k127_6511532_16 nUDIX hydrolase K03574,K03575 - 3.6.1.55 0.0000000000000000000000000000000000000000000000000001958 188.0
TLS1_k127_6511532_18 LysM domain - - - 0.00000000000000000000000000000000000000007051 158.0
TLS1_k127_6511532_2 Transcriptional regulator - - - 5.192e-273 856.0
TLS1_k127_6511532_20 protein-S-isoprenylcysteine methyltransferase - - - 0.000000000000000000000000000000000007169 143.0
TLS1_k127_6511532_22 nuclease activity K06218 - - 0.00000000000000000000000000000000664 128.0
TLS1_k127_6511532_23 Nucleotidyltransferase domain K07075 - - 0.000000000000000000000005364 104.0
TLS1_k127_6511532_26 Protein of unknown function DUF86 - - - 0.000000000002569 69.0
TLS1_k127_6511532_29 Protein of unknown function DUF86 - - - 0.000003735 52.0
TLS1_k127_6511532_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 3.914e-249 776.0
TLS1_k127_6511532_4 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 612.0
TLS1_k127_6511532_5 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 590.0
TLS1_k127_6511532_6 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 529.0
TLS1_k127_6511532_7 Acetyl-coenzyme A transporter 1 K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 462.0
TLS1_k127_6511532_8 THUMP K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 424.0
TLS1_k127_6511532_9 FES K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 411.0
TLS1_k127_6517550_0 ATPase involved in DNA repair K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 391.0
TLS1_k127_6517550_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K01115 - 3.1.4.4 0.0000000000000000000000000000000000000000000001656 191.0
TLS1_k127_6517550_2 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.0000000000003621 69.0
TLS1_k127_6561621_0 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 342.0
TLS1_k127_6561621_1 Elongation factor G, domain IV K02355 - - 0.0000000000000000000000000000000000000000000006745 171.0
TLS1_k127_6561621_2 - - - - 0.0000000000000000000000000009967 112.0
TLS1_k127_6562859_0 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006758 479.0
TLS1_k127_6562859_1 Domain of unknown function (DUF5069) - - - 0.000000000000000000000000000000000000000000000001741 179.0
TLS1_k127_6562859_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000001316 115.0
TLS1_k127_6590052_0 chlorophyll binding K03640 - - 0.000000000000000000000000000000000000005771 149.0
TLS1_k127_6590052_1 PFAM nuclease (SNase domain protein) - - - 0.0000000000000000000000000221 114.0
TLS1_k127_6612428_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 8.099e-301 934.0
TLS1_k127_6612428_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 2.228e-249 779.0
TLS1_k127_6612428_10 Asparaginase K13051 - 3.4.19.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000848 258.0
TLS1_k127_6612428_11 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000002156 194.0
TLS1_k127_6612428_12 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000006237 190.0
TLS1_k127_6612428_13 TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family K00241 - - 0.000000000000000000000000000000000000000000000000002532 189.0
TLS1_k127_6612428_15 efflux transmembrane transporter activity K03287 - - 0.00000000000000000000000000000000000004451 145.0
TLS1_k127_6612428_16 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000006078 145.0
TLS1_k127_6612428_18 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.000000000000000000000001644 112.0
TLS1_k127_6612428_19 Membrane K08988 - - 0.00000000000000000002733 100.0
TLS1_k127_6612428_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 416.0
TLS1_k127_6612428_21 protein histidine kinase activity - - - 0.0000000001253 68.0
TLS1_k127_6612428_22 diguanylate cyclase - - - 0.00000009034 57.0
TLS1_k127_6612428_23 efflux transmembrane transporter activity K03287 - - 0.000006211 52.0
TLS1_k127_6612428_3 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 384.0
TLS1_k127_6612428_4 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 336.0
TLS1_k127_6612428_5 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 331.0
TLS1_k127_6612428_6 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 319.0
TLS1_k127_6612428_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 316.0
TLS1_k127_6612428_8 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 315.0
TLS1_k127_66286_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 3.129e-313 973.0
TLS1_k127_66286_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 5.687e-261 817.0
TLS1_k127_66286_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 288.0
TLS1_k127_66286_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000004212 156.0
TLS1_k127_6645578_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 364.0
TLS1_k127_6648646_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 532.0
TLS1_k127_6648646_1 ATPase activity K02013,K02028,K05776 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21,3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 397.0
TLS1_k127_6648646_2 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008398 278.0
TLS1_k127_6648646_3 RNA-DNA hybrid ribonuclease activity K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001638 289.0
TLS1_k127_6648646_4 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.000000000000000000000000000000000000003811 152.0
TLS1_k127_6648646_5 Uncharacterized ACR, COG1993 K06199,K09137 - - 0.000000000000000000000000000001048 124.0
TLS1_k127_6648646_6 - - - - 0.00000000001018 75.0
TLS1_k127_665928_1 Transposase - - - 0.00000000000000000006682 101.0
TLS1_k127_6672564_0 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002149 249.0
TLS1_k127_6672564_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.0000000000000000000000000000000000000000000000000000026 198.0
TLS1_k127_6672564_2 AMP binding K11932 - - 0.00000000000000000000000000000000001046 139.0
TLS1_k127_6674273_0 dead DEAH box helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 2.613e-281 875.0
TLS1_k127_6674273_1 dead DEAH box helicase K03727 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 445.0
TLS1_k127_6674273_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 413.0
TLS1_k127_6679141_0 PFAM FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 598.0
TLS1_k127_6679141_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 536.0
TLS1_k127_6679141_2 Protein of unknown function (DUF3703) - - - 0.00000000000000000000000000000000005827 136.0
TLS1_k127_6680443_0 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 400.0
TLS1_k127_6680443_1 Hsp90 protein K04079 - - 0.0007362 51.0
TLS1_k127_6680443_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0007961 44.0
TLS1_k127_6687243_0 membrane - - - 0.00000000000000000000000000000000000000007345 154.0
TLS1_k127_6704101_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 1.091e-200 632.0
TLS1_k127_6704101_1 NeuB family K03856 - 2.5.1.54 2.385e-200 626.0
TLS1_k127_6704101_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 449.0
TLS1_k127_6704101_3 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000007656 263.0
TLS1_k127_6704101_4 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000001477 101.0
TLS1_k127_6710432_0 Participates in both transcription termination and antitermination K02600 - - 2.701e-211 660.0
TLS1_k127_6710432_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000000002513 216.0
TLS1_k127_6710432_2 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000005914 188.0
TLS1_k127_6711069_0 Transposase IS116/IS110/IS902 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 478.0
TLS1_k127_6723392_0 siderophore transport K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003944 499.0
TLS1_k127_6723392_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000003296 170.0
TLS1_k127_6726943_0 - - - - 0.0000000000000000000000000000000000000000004471 156.0
TLS1_k127_6726943_1 - - - - 0.000000000002945 68.0
TLS1_k127_6740366_0 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 409.0
TLS1_k127_6740366_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 328.0
TLS1_k127_6740366_2 Phosphoserine phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 292.0
TLS1_k127_6740366_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008733 291.0
TLS1_k127_6740366_4 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000001203 203.0
TLS1_k127_6740366_5 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000004521 206.0
TLS1_k127_6740366_6 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K11527 - 2.7.13.3 0.000000000000000000000000000000000000000000001191 183.0
TLS1_k127_6743369_0 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 385.0
TLS1_k127_6794940_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1071.0
TLS1_k127_6794940_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 568.0
TLS1_k127_6794940_2 response regulator K02479,K07685 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000409 248.0
TLS1_k127_6794940_3 RNA recognition motif - - - 0.00000000000000000000000000000000000000000000003237 171.0
TLS1_k127_6794940_9 - - - - 0.0001627 48.0
TLS1_k127_682546_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 1.425e-242 756.0
TLS1_k127_682546_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001697 254.0
TLS1_k127_682546_2 COG2206 HD-GYP domain - - - 0.00001261 49.0
TLS1_k127_682546_3 Glycoprotease family K14742 - - 0.00003872 46.0
TLS1_k127_6844362_0 Winged helix-turn helix - - - 0.00000000000000000000000000000000000000000006281 166.0
TLS1_k127_6844362_1 COG3335 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000002847 155.0
TLS1_k127_6844362_2 Uracil DNA glycosylase superfamily K03649 - 3.2.2.28 0.000000000008185 66.0
TLS1_k127_6869532_0 Tn3 transposase DDE domain - - - 3.15e-220 694.0
TLS1_k127_6869532_1 PFAM Transposase, IS4-like - - - 0.000000000004473 75.0
TLS1_k127_687172_0 PFAM Alpha amylase K00700 - 2.4.1.18 1.829e-245 773.0
TLS1_k127_687172_1 COG0457 FOG TPR repeat - - - 1.029e-224 711.0
TLS1_k127_687172_10 Heavy metal translocating P-type atpase K17686 - 3.6.3.54 0.000000000006664 68.0
TLS1_k127_687172_11 3'(2'),5'-bisphosphate nucleotidase activity K01082 GO:0000287,GO:0003674,GO:0003824,GO:0004441,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016311,GO:0016312,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019693,GO:0032501,GO:0032502,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0048731,GO:0048856,GO:0050427,GO:0052745,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 3.1.3.7 0.00000000121 64.0
TLS1_k127_687172_12 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000001536 51.0
TLS1_k127_687172_13 TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate K00172 - 1.2.7.1 0.000005563 50.0
TLS1_k127_687172_14 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 0.0001172 44.0
TLS1_k127_687172_2 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008626 525.0
TLS1_k127_687172_3 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 370.0
TLS1_k127_687172_4 transmembrane signaling receptor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001629 269.0
TLS1_k127_687172_5 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001292 267.0
TLS1_k127_687172_6 alpha-glucan phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000002184 192.0
TLS1_k127_687172_7 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate K00172 - 1.2.7.1 0.0000000000000000000000000004053 118.0
TLS1_k127_687172_8 alpha-glucan phosphorylase K00688 - 2.4.1.1 0.00000000000000000002405 91.0
TLS1_k127_687172_9 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000001997 78.0
TLS1_k127_6895900_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 1.667e-273 846.0
TLS1_k127_6895900_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 1.003e-215 674.0
TLS1_k127_6895900_10 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 303.0
TLS1_k127_6895900_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003124 240.0
TLS1_k127_6895900_12 Carbon-nitrogen hydrolase K03820 - - 0.00000000000000000000000000000000000000000000000000000004192 198.0
TLS1_k127_6895900_13 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000009474 156.0
TLS1_k127_6895900_2 MacB-like periplasmic core domain K09808 - - 1.167e-197 623.0
TLS1_k127_6895900_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 576.0
TLS1_k127_6895900_4 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007972 492.0
TLS1_k127_6895900_5 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 434.0
TLS1_k127_6895900_6 Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 400.0
TLS1_k127_6895900_7 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 363.0
TLS1_k127_6895900_8 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 336.0
TLS1_k127_6895900_9 Peptidase C26 K01658 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 331.0
TLS1_k127_6901423_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000000000005096 125.0
TLS1_k127_6901423_1 COG3039 Transposase and inactivated derivatives, IS5 family K07481 - - 0.00000003609 62.0
TLS1_k127_6905431_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 338.0
TLS1_k127_6905431_1 trisaccharide binding - - - 0.000000000000000000000005553 106.0
TLS1_k127_6919488_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1131.0
TLS1_k127_6919488_1 efflux transmembrane transporter activity K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 597.0
TLS1_k127_6919488_2 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 528.0
TLS1_k127_6919488_4 RNA recognition motif - - - 0.00000000000000000000000000000000000000002061 156.0
TLS1_k127_6919488_6 Domain of unknown function (DUF4321) - - - 0.0000000000000000000000000000002269 124.0
TLS1_k127_695149_0 ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 399.0
TLS1_k127_695149_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000004496 210.0
TLS1_k127_695149_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000008808 123.0
TLS1_k127_6958142_0 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 468.0
TLS1_k127_6958142_1 Leucyl/phenylalanyl-tRNA protein transferase K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000384 278.0
TLS1_k127_6958142_2 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000001598 177.0
TLS1_k127_7086731_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 567.0
TLS1_k127_7090861_0 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000000000000005422 155.0
TLS1_k127_7093096_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.281e-297 917.0
TLS1_k127_7093096_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.719e-248 775.0
TLS1_k127_7093096_2 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000000000000000282 200.0
TLS1_k127_7093096_3 Bacterial protein of unknown function (DUF948) - - - 0.000000000000000000000000000000000000000000001751 168.0
TLS1_k127_7093096_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000001441 108.0
TLS1_k127_7095479_0 Type II/IV secretion system protein K02454,K02652 - - 0.000000000000000000000000000000000000001034 149.0
TLS1_k127_7095479_1 type IV pilus modification protein PilV K02671,K02681,K10927 - - 0.000000000000000000000002351 109.0
TLS1_k127_7095479_3 protein transport across the cell outer membrane - - - 0.00000000002432 71.0
TLS1_k127_7096485_0 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0 1077.0
TLS1_k127_7096485_1 Bacterial regulatory protein, Fis family K02481,K07713,K07714 - - 1.491e-243 760.0
TLS1_k127_7096485_10 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000002466 84.0
TLS1_k127_7096485_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005823 531.0
TLS1_k127_7096485_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 492.0
TLS1_k127_7096485_4 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 486.0
TLS1_k127_7096485_5 response regulator K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 417.0
TLS1_k127_7096485_6 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 316.0
TLS1_k127_7096485_7 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004169 238.0
TLS1_k127_7096485_8 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000000000000000000000000000004717 218.0
TLS1_k127_7096485_9 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000692 170.0
TLS1_k127_7109044_0 PFAM Integrase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007584 377.0
TLS1_k127_7109044_1 Integrase core domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000002247 215.0
TLS1_k127_7109044_10 - - - - 0.000000000346 69.0
TLS1_k127_7109044_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000001055 211.0
TLS1_k127_7109044_3 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000004123 169.0
TLS1_k127_7109044_4 Protein of unknown function (DUF1778) - - - 0.0000000000000000000000001871 109.0
TLS1_k127_7109044_5 Transposase - - - 0.0000000000000000000001516 103.0
TLS1_k127_7109044_6 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000004981 90.0
TLS1_k127_7109044_7 - - - - 0.00000000000000002559 85.0
TLS1_k127_7109044_8 transposase activity K07483 - - 0.0000000000001158 74.0
TLS1_k127_7109044_9 - - - - 0.00000000000951 68.0
TLS1_k127_7111256_0 Transposase K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 451.0
TLS1_k127_7112367_0 RF-1 domain K15034 - - 0.00000000000000000000000000000000000000000000000002905 181.0
TLS1_k127_7112367_1 peptidyl-tyrosine sulfation - - - 0.0000003356 53.0
TLS1_k127_7124060_0 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 399.0
TLS1_k127_7124060_1 - - - - 0.00000000000000001642 85.0
TLS1_k127_7124060_2 Transcriptional regulator - - - 0.00000000000000004499 86.0
TLS1_k127_7124060_3 - - - - 0.000000002217 63.0
TLS1_k127_7138246_0 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 516.0
TLS1_k127_7138333_0 - - - - 0.0000000000000000000000000000000000000000000000000000003332 202.0
TLS1_k127_7138333_1 RNA recognition motif - - - 0.000000000000000000000000000000000000000001736 158.0
TLS1_k127_7138333_2 Predicted nucleotide-binding protein containing TIR-like domain - - - 0.000000000000000000000000000000000006099 139.0
TLS1_k127_714620_0 AAA ATPase domain K02450 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 587.0
TLS1_k127_714620_1 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000001867 224.0
TLS1_k127_714620_2 identical protein binding K07285 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0019867,GO:0042802 - 0.00000000000000000000000001705 116.0
TLS1_k127_7147069_0 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 494.0
TLS1_k127_7147069_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 323.0
TLS1_k127_7147069_2 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000009969 179.0
TLS1_k127_7147069_3 Domain of unknown function (DUF4160) - - - 0.0000000000000000000000000000000000000000002389 161.0
TLS1_k127_7147069_4 response to heat K07090 - - 0.00000000000000000000000000000000000000006363 153.0
TLS1_k127_7147069_5 - - - - 0.0000000000000000000000000000000000003895 141.0
TLS1_k127_7147069_6 Protein of unknown function (DUF2442) - - - 0.00000000000000000000000000000000003706 137.0
TLS1_k127_7147069_7 sequence-specific DNA binding K07726 - - 0.00000000000002243 78.0
TLS1_k127_7147069_9 sequence-specific DNA binding K07726 - - 0.00004046 47.0
TLS1_k127_7148485_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 467.0
TLS1_k127_7148485_1 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 298.0
TLS1_k127_7155828_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000004794 224.0
TLS1_k127_7155828_1 - - - - 0.00000000000000000000000000001473 123.0
TLS1_k127_7156914_0 IMG reference gene - - - 0.00000000000000000000000000000000000000000000000009377 185.0
TLS1_k127_7156914_1 PFAM transposase, IS4 family protein - - - 0.0000000000000004997 85.0
TLS1_k127_7162974_0 Ftsk_gamma K03466 - - 2.203e-280 875.0
TLS1_k127_7162974_1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 387.0
TLS1_k127_7162974_2 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 310.0
TLS1_k127_7168234_0 Protein of unknown function, DUF255 K06888 - - 0.0 1521.0
TLS1_k127_7168234_1 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 5.023e-242 754.0
TLS1_k127_7168234_10 arsenate reductase (glutaredoxin) activity K00537 - 1.20.4.1 0.0000000000000000000000000000000000000000001017 164.0
TLS1_k127_7168234_11 phosphohistidine phosphatase, SixA K08296 - - 0.000000000000000000000000000000000001691 144.0
TLS1_k127_7168234_14 Transposase K07485 - - 0.00000003183 66.0
TLS1_k127_7168234_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01524,K07012 - 3.6.1.11,3.6.1.40 1.533e-214 677.0
TLS1_k127_7168234_3 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002763 499.0
TLS1_k127_7168234_4 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005215 494.0
TLS1_k127_7168234_5 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002593 289.0
TLS1_k127_7168234_6 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001302 280.0
TLS1_k127_7168234_7 heat shock protein binding K05516,K05801,K18481 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007123 265.0
TLS1_k127_7168234_8 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000195 232.0
TLS1_k127_7168668_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 602.0
TLS1_k127_7168668_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001401 263.0
TLS1_k127_7168668_2 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000000000000000000000001915 181.0
TLS1_k127_7168668_3 Putative regulatory protein - - - 0.000000000000000000000000003827 114.0
TLS1_k127_7168668_5 - - - - 0.000000000001156 67.0
TLS1_k127_7175416_0 cobalamin-transporting ATPase activity K02014,K16092 - - 5.156e-231 735.0
TLS1_k127_7175416_1 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 - 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008168 529.0
TLS1_k127_7175416_10 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 319.0
TLS1_k127_7175416_11 cob(I)yrinic acid a,c-diamide adenosyltransferase activity K00798,K13821 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.2.1.88,1.5.5.2,2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 316.0
TLS1_k127_7175416_12 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 297.0
TLS1_k127_7175416_13 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 299.0
TLS1_k127_7175416_14 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002173 249.0
TLS1_k127_7175416_15 Cobinamide kinase / cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000000000000000000000000000000001602 189.0
TLS1_k127_7175416_17 PFAM HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000009921 138.0
TLS1_k127_7175416_19 Adenosylcobinamide amidohydrolase - - - 0.00000000000000000000000006011 117.0
TLS1_k127_7175416_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 456.0
TLS1_k127_7175416_20 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000001155 92.0
TLS1_k127_7175416_21 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000002471 77.0
TLS1_k127_7175416_22 Pyruvate phosphate dikinase - - - 0.0000000000004358 72.0
TLS1_k127_7175416_23 membrane - - - 0.00000006541 59.0
TLS1_k127_7175416_3 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 445.0
TLS1_k127_7175416_4 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 404.0
TLS1_k127_7175416_5 Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 389.0
TLS1_k127_7175416_6 coenzyme F420-1:gamma-L-glutamate ligase activity K00768,K04719 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016491,GO:0016705,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.13.11.79,2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009677 342.0
TLS1_k127_7175416_7 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 349.0
TLS1_k127_7175416_8 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 336.0
TLS1_k127_7175416_9 NAD(P)H-binding K07118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 318.0
TLS1_k127_7176100_0 structural constituent of ribosome K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009536,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000004432 221.0
TLS1_k127_7176100_1 Cell wall-associated hydrolase - - - 0.00000000000000000000000000000000000000000000000000000003136 196.0
TLS1_k127_7176100_10 - - - - 0.0000000000000000000000000000000003843 132.0
TLS1_k127_7176100_11 Cell wall-associated hydrolase - - - 0.00000000000000000000000000000004175 127.0
TLS1_k127_7176100_12 - - - - 0.00000000000000000000000000000006386 125.0
TLS1_k127_7176100_13 - - - - 0.00000000000000000000000000001236 119.0
TLS1_k127_7176100_14 ATP synthase subunit a, chloroplastic - - - 0.00000000000000000000000285 105.0
TLS1_k127_7176100_15 - - - - 0.000000000000000000000003615 102.0
TLS1_k127_7176100_17 - - - - 0.00000000000000000000008111 100.0
TLS1_k127_7176100_18 - - - - 0.000000000000000000001357 94.0
TLS1_k127_7176100_2 - - - - 0.000000000000000000000000000000000000000000000000003328 181.0
TLS1_k127_7176100_23 - - - - 0.00000000000009566 70.0
TLS1_k127_7176100_26 - - - - 0.000000000001666 68.0
TLS1_k127_7176100_27 - - - - 0.000000000003674 69.0
TLS1_k127_7176100_3 - - - - 0.000000000000000000000000000000000000000000000000004572 182.0
TLS1_k127_7176100_30 - - - - 0.000000001409 60.0
TLS1_k127_7176100_31 - - - - 0.00000001129 57.0
TLS1_k127_7176100_32 Protein of unknown function (DUF2647) - - - 0.0000001206 56.0
TLS1_k127_7176100_34 - - - - 0.0000002634 53.0
TLS1_k127_7176100_35 - - - - 0.000009839 48.0
TLS1_k127_7176100_36 - - - - 0.00006219 47.0
TLS1_k127_7176100_5 Cell wall-associated hydrolase - - - 0.000000000000000000000000000000000000000001366 156.0
TLS1_k127_7176100_6 Cell wall-associated hydrolase - - - 0.00000000000000000000000000000000000001763 144.0
TLS1_k127_7176100_8 - - - - 0.000000000000000000000000000000000001216 138.0
TLS1_k127_7176100_9 - - - - 0.000000000000000000000000000000000001855 139.0
TLS1_k127_7178493_0 response to heat K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000002087 233.0
TLS1_k127_7178493_1 Lipocalin-like domain - - - 0.000000000000000001767 86.0
TLS1_k127_7178493_2 - - - - 0.0000001054 55.0
TLS1_k127_7184616_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0 1067.0
TLS1_k127_7184616_2 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000004894 111.0
TLS1_k127_7184616_3 PFAM Plasmid stabilisation system protein - - - 0.00000000000000000000005169 101.0
TLS1_k127_7184616_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000006545 83.0
TLS1_k127_7184616_5 Putative addiction module component - - - 0.00000000003458 67.0
TLS1_k127_7184616_6 - - - - 0.00005418 46.0
TLS1_k127_7186628_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008082 380.0
TLS1_k127_7186628_1 photosystem II stabilization K02237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004237 252.0
TLS1_k127_7186628_3 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000001238 113.0
TLS1_k127_7188417_0 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 483.0
TLS1_k127_7188417_1 pyruvate decarboxylase activity K04103 - 4.1.1.74 0.000000000000000000000000000000000000000001877 156.0
TLS1_k127_7190373_0 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000002538 211.0
TLS1_k127_7190373_2 DNA integration - - - 0.00000000000000000000000001505 118.0
TLS1_k127_7190373_3 DNA integration K14059 - - 0.000000000000000000000003278 104.0
TLS1_k127_7190373_4 - - - - 0.000000784 53.0
TLS1_k127_7190373_5 Replication initiation factor K07467 - - 0.000002018 52.0
TLS1_k127_7196548_0 Cytochrome c - - - 5.247e-236 739.0
TLS1_k127_7196548_1 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000004293 249.0
TLS1_k127_7196548_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000001567 216.0
TLS1_k127_7196548_3 Bacterial protein of unknown function (DUF948) - - - 0.000000000000000000000000000006856 123.0
TLS1_k127_7196548_4 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.000000000000003525 77.0
TLS1_k127_7196548_5 - - - - 0.000000000000005819 81.0
TLS1_k127_7196548_6 transposase IS4 IS5 family K07492 - - 0.00000000000008061 76.0
TLS1_k127_7196548_7 PFAM Plasmid pRiA4b ORF-3-like protein - - - 0.0000000009091 61.0
TLS1_k127_7196548_8 YtxH-like protein - - - 0.000000001007 65.0
TLS1_k127_7196548_9 - - - - 0.0003328 44.0
TLS1_k127_7230470_0 K02A2.6-like - - - 0.00000000000000000000000000000000000000000000000000000000006856 234.0
TLS1_k127_7230470_1 PHD-finger - - - 0.00000121 59.0
TLS1_k127_7253030_0 Tigger transposable - - - 0.00002261 55.0
TLS1_k127_7260474_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1362.0
TLS1_k127_7260474_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 1.004e-262 814.0
TLS1_k127_7260474_2 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 481.0
TLS1_k127_7260474_3 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007809 401.0
TLS1_k127_7260474_4 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 347.0
TLS1_k127_7260474_5 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000000000000000006484 220.0
TLS1_k127_7261343_0 Membrane K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 295.0
TLS1_k127_7261343_1 Membrane K08984 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002666 260.0
TLS1_k127_7261343_2 AhpC/TSA family K03386 - 1.11.1.15 0.0000005554 51.0
TLS1_k127_7276364_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity - - - 0.0 1239.0
TLS1_k127_7276364_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000019 253.0
TLS1_k127_7276364_2 Cytochrome c - - - 0.0000000000000000000000000000000004663 145.0
TLS1_k127_7276364_3 PFAM NapC NirT cytochrome c K02569 - - 0.000000000000000000004241 93.0
TLS1_k127_7276364_4 Small metal-binding protein - - - 0.0000000000003546 75.0
TLS1_k127_7277454_0 4Fe-4S dicluster domain K16950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 419.0
TLS1_k127_7277454_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000361 268.0
TLS1_k127_728862_0 Transglycosylase associated protein - - - 0.0000000000000000000000002814 107.0
TLS1_k127_728862_1 - - - - 0.000000000000000000001935 94.0
TLS1_k127_728862_2 response regulator - - - 0.00000000000000000004616 96.0
TLS1_k127_728862_3 Hemerythrin HHE cation binding domain - - - 0.00002373 52.0
TLS1_k127_7288851_1 - K21495 - - 0.0000000007831 61.0
TLS1_k127_7288851_2 nuclease activity K18828 - - 0.000000003931 61.0
TLS1_k127_7288851_3 transposase activity K07483 - - 0.0001109 46.0
TLS1_k127_7295986_0 DNA topoisomerase II activity K03167 - 5.99.1.3 0.0 1024.0
TLS1_k127_7295986_1 Type III restriction enzyme res subunit - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 4.916e-255 795.0
TLS1_k127_7295986_2 DNA topoisomerase VI subunit A K03166 - 5.99.1.3 3.593e-221 687.0
TLS1_k127_7295986_3 Domain of unknown function (DUF3817) - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000004852 97.0
TLS1_k127_7295986_4 Encoded by - - - 0.00000008127 63.0
TLS1_k127_7295986_5 Endonuclease/Exonuclease/phosphatase family - - - 0.00002461 49.0
TLS1_k127_7296425_0 phosphate ion binding K02040 - - 0.00000000000000000000000000000000001064 137.0
TLS1_k127_7302029_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 386.0
TLS1_k127_7302029_1 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000009648 224.0
TLS1_k127_7326806_0 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000781 380.0
TLS1_k127_7326806_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000002341 113.0
TLS1_k127_7326806_2 PFAM Response regulator receiver domain - - - 0.000000000000000000002336 111.0
TLS1_k127_7326806_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.00000005622 55.0
TLS1_k127_7326806_4 - - - - 0.00000006473 55.0
TLS1_k127_7326806_5 - - - - 0.00006543 49.0
TLS1_k127_7331335_0 helix_turn_helix, Lux Regulon K03556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 376.0
TLS1_k127_7345514_0 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000005219 216.0
TLS1_k127_7345514_1 Ftsk_gamma K03466 - - 0.000000000000000000000000000000000000000000000000005524 186.0
TLS1_k127_7349288_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 7.562e-257 804.0
TLS1_k127_7349288_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000002346 76.0
TLS1_k127_7359685_0 molybdopterin cofactor binding K00370,K10700,K16964,K17050 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 0.0 2039.0
TLS1_k127_7359685_1 FtsX-like permease family K02004 - - 0.0 1038.0
TLS1_k127_7359685_11 - - - - 0.00000001408 56.0
TLS1_k127_7359685_12 Protein of unknown function (DUF433) - - - 0.00007901 46.0
TLS1_k127_7359685_2 Transglutaminase/protease-like homologues - - - 3.184e-198 641.0
TLS1_k127_7359685_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008887 497.0
TLS1_k127_7359685_5 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 341.0
TLS1_k127_7359685_6 lipoprotein transporter activity K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 318.0
TLS1_k127_7359685_7 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 319.0
TLS1_k127_7359685_8 lipolytic protein G-D-S-L family K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000007612 261.0
TLS1_k127_7359685_9 zinc ion binding - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000001145 200.0
TLS1_k127_7365288_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.452e-235 737.0
TLS1_k127_7365288_1 Histidine kinase K00060,K07777 - 1.1.1.103,2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 520.0
TLS1_k127_7365288_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000006962 228.0
TLS1_k127_7365288_3 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001041 200.0
TLS1_k127_73776_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000003565 238.0
TLS1_k127_7383818_0 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.00000000000000000000000000000000000000000000001476 176.0
TLS1_k127_7383818_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.0000000000000000000000000000000000001806 150.0
TLS1_k127_7383818_2 - - - - 0.000000000000000000000000000004973 132.0
TLS1_k127_7398099_0 Phage integrase, N-terminal SAM-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 422.0
TLS1_k127_7398099_1 DNA excision K02806 - - 0.0000000000000000000000001553 110.0
TLS1_k127_7398099_2 - - - - 0.000001612 50.0
TLS1_k127_7412487_0 Monoamine oxidase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 542.0
TLS1_k127_7412487_1 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 502.0
TLS1_k127_7412487_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 364.0
TLS1_k127_7412487_3 allophanate hydrolase subunit 2 K01457,K01941,K06350 - 3.5.1.54,6.3.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 296.0
TLS1_k127_7412487_4 5-oxoprolinase (ATP-hydrolyzing) activity K01457,K06351,K07160 - 3.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000003573 245.0
TLS1_k127_7412487_5 5-oxoprolinase (ATP-hydrolyzing) activity K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000001934 235.0
TLS1_k127_7412487_6 Dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000001386 237.0
TLS1_k127_7412487_7 - - - - 0.00000001333 56.0
TLS1_k127_7422469_0 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 6.864e-264 815.0
TLS1_k127_7422469_1 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 375.0
TLS1_k127_7422469_5 phosphatase - - - 0.0001341 45.0
TLS1_k127_7422469_6 - - - - 0.0005702 50.0
TLS1_k127_7430791_0 DDE superfamily endonuclease K07494 - - 0.00000000000000000000000000000000000000000000000000000000002294 210.0
TLS1_k127_7430791_1 Transposase K07499 - - 0.0000000000000000000000000000000000000000000000126 175.0
TLS1_k127_7442567_0 PFAM Uncharacterised protein family (UPF0164) - - - 0.00000000000000000000000000001314 130.0
TLS1_k127_7450516_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1045.0
TLS1_k127_7450516_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0 1004.0
TLS1_k127_7450516_2 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 2.65e-227 711.0
TLS1_k127_7450516_3 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 478.0
TLS1_k127_7450516_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 350.0
TLS1_k127_7450516_5 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 299.0
TLS1_k127_7450516_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003036 254.0
TLS1_k127_7450516_7 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000123 214.0
TLS1_k127_7450629_0 - - - - 0.0000000000000000000000000000000000000000000000000000000001778 205.0
TLS1_k127_7450629_1 - - - - 0.0000000000000000000000000000000000000367 153.0
TLS1_k127_7450629_2 - - - - 0.00000000000000000266 84.0
TLS1_k127_7450629_3 - - - - 0.000000000000009821 74.0
TLS1_k127_7450629_4 - - - - 0.00000000007315 63.0
TLS1_k127_7450629_5 - - - - 0.0000004949 53.0
TLS1_k127_7462211_0 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 526.0
TLS1_k127_7462211_1 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 529.0
TLS1_k127_7462211_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 408.0
TLS1_k127_7462211_3 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 301.0
TLS1_k127_7462211_4 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000000378 156.0
TLS1_k127_7462211_5 self proteolysis - - - 0.000000000000000000000000000004874 131.0
TLS1_k127_7462211_6 peptide catabolic process - - - 0.0000000000000000000000000003777 120.0
TLS1_k127_7468062_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.211e-296 930.0
TLS1_k127_7468062_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 1.856e-227 710.0
TLS1_k127_7468062_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 2.127e-198 623.0
TLS1_k127_7468062_4 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE - - - 0.000215 44.0
TLS1_k127_7473003_0 transmembrane transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002702 264.0
TLS1_k127_747505_0 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.0 1326.0
TLS1_k127_747505_1 FAD binding domain K00239 - 1.3.5.1,1.3.5.4 2.152e-276 852.0
TLS1_k127_747505_2 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 449.0
TLS1_k127_747505_3 Aconitase C-terminal domain K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001672 278.0
TLS1_k127_7481297_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 350.0
TLS1_k127_7485315_0 Subunit R is required for both nuclease and ATPase activities, but not for modification K01153 - 3.1.21.3 6.844e-299 929.0
TLS1_k127_7492656_0 Evidence 4 Homologs of previously reported genes of K07114,K08309 - - 3.155e-254 806.0
TLS1_k127_7492656_1 phospho-N-acetylmuramoyl-pentapeptide-transferase activity K01791,K02851 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.8.33,2.7.8.35,5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 545.0
TLS1_k127_7492656_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01991 - - 0.0000000000000000000000000000000000000000000000000000000000001233 216.0
TLS1_k127_7492866_0 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 526.0
TLS1_k127_7496550_0 PFAM transposase mutator type - - - 0.0000000000000000000000000004666 128.0
TLS1_k127_7500838_0 Multicopper oxidase type 1 - - - 2.186e-241 766.0
TLS1_k127_7500838_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 513.0
TLS1_k127_7500838_2 Copper resistance protein B precursor (CopB) K07233 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 314.0
TLS1_k127_7500838_3 Uncharacterised BCR, YnfA/UPF0060 family - - - 0.00000000000000000000000000000000003482 136.0
TLS1_k127_7526231_0 microcin transport K06160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 527.0
TLS1_k127_7526231_1 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 409.0
TLS1_k127_7526231_2 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 389.0
TLS1_k127_7526231_3 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 357.0
TLS1_k127_7526231_4 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 338.0
TLS1_k127_7526231_5 cellular manganese ion homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000002697 226.0
TLS1_k127_7526231_6 response to oxidative stress K04063 - - 0.0000000000000000000000000000000000000000000000000000000000000002203 222.0
TLS1_k127_7526231_7 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000000000000000000000000000000000489 181.0
TLS1_k127_7526231_8 Belongs to the P-Pant transferase superfamily K06133 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008897,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0019752,GO:0019878,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000001622 157.0
TLS1_k127_7526231_9 Cytochrome c K12263 - - 0.00000000000000000000008579 102.0
TLS1_k127_7528807_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 529.0
TLS1_k127_7528807_1 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 511.0
TLS1_k127_7528807_10 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000004789 177.0
TLS1_k127_7528807_12 transposase and inactivated derivatives, IS30 family - - - 0.0000000000000000000000000000001265 128.0
TLS1_k127_7528807_14 - - - - 0.000004196 52.0
TLS1_k127_7528807_2 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 468.0
TLS1_k127_7528807_3 DNA-binding transcription factor activity K04761 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 463.0
TLS1_k127_7528807_4 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 459.0
TLS1_k127_7528807_5 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 429.0
TLS1_k127_7528807_6 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 389.0
TLS1_k127_7528807_7 Ferritin-like domain K04047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002941 250.0
TLS1_k127_7528807_8 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005732 253.0
TLS1_k127_7528807_9 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000129 231.0
TLS1_k127_7542607_0 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K00387 - 1.8.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 543.0
TLS1_k127_7542607_1 Putative neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 346.0
TLS1_k127_7542607_2 Protein of unknown function (DUF2959) - - - 0.0000000000000000000000000000000000000000000000000000000000006908 217.0
TLS1_k127_7542607_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07285 - - 0.00000000000000000000000000000000005577 140.0
TLS1_k127_7542607_4 - - - - 0.0000000004979 63.0
TLS1_k127_7544456_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.992e-206 656.0
TLS1_k127_7544456_1 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 465.0
TLS1_k127_7544456_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 437.0
TLS1_k127_7544456_3 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 381.0
TLS1_k127_7544456_4 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 356.0
TLS1_k127_7544456_5 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000005546 159.0
TLS1_k127_7544456_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000001313 108.0
TLS1_k127_7544456_7 ribonuclease P activity K03536,K08998 GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.0000000000000000000000004179 108.0
TLS1_k127_7544456_8 - - - - 0.00000000001495 73.0
TLS1_k127_7544456_9 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000003214 61.0
TLS1_k127_7559534_0 - - - - 5.68e-209 664.0
TLS1_k127_7563457_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1131.0
TLS1_k127_7563457_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00371,K16965,K17048,K17051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 5.673e-301 923.0
TLS1_k127_7563457_2 cellulose binding - - - 4.922e-239 741.0
TLS1_k127_7563457_3 molybdopterin cofactor binding K00370,K10700,K16964,K17050 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 591.0
TLS1_k127_7563457_4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003924 506.0
TLS1_k127_7563457_5 Component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 331.0
TLS1_k127_7563457_6 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000000005882 193.0
TLS1_k127_7563457_7 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000001098 157.0
TLS1_k127_7563457_8 YCII-related domain - - - 0.000000000000000000000000000000000000000001268 159.0
TLS1_k127_7567777_0 peptidyl-tyrosine sulfation K02450 - - 0.00000000000000000000000000000000002762 139.0
TLS1_k127_7567777_1 peptidyl-tyrosine sulfation K02450 - - 0.0000000000001373 76.0
TLS1_k127_756999_0 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 381.0
TLS1_k127_7572163_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009684 335.0
TLS1_k127_7572477_0 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000005471 203.0
TLS1_k127_7572477_1 Virulence factor BrkB - - - 0.000000000000000000000000000005902 124.0
TLS1_k127_7574797_0 TIGRFAM phosphate binding protein K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 355.0
TLS1_k127_7574797_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000002905 154.0
TLS1_k127_7585882_0 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 372.0
TLS1_k127_7585882_1 NB-ARC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 379.0
TLS1_k127_7585882_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004615 228.0
TLS1_k127_7585882_3 PFAM helix-turn-helix domain protein - - - 0.000000000000000000000000000000000000000002447 160.0
TLS1_k127_7585882_4 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000786 45.0
TLS1_k127_7595956_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1406.0
TLS1_k127_7595956_1 Bacterial regulatory protein, Fis family K07715 - - 1.091e-233 730.0
TLS1_k127_7595956_11 Protein of unknown function (DUF423) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000002179 145.0
TLS1_k127_7595956_12 sequence-specific DNA binding - - - 0.00000000000000000000000000000003799 127.0
TLS1_k127_7595956_14 Polymer-forming cytoskeletal - - - 0.000000000000000000000000002537 116.0
TLS1_k127_7595956_16 nuclease activity K18828 - - 0.00000000005891 63.0
TLS1_k127_7595956_2 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 1.038e-227 715.0
TLS1_k127_7595956_3 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 560.0
TLS1_k127_7595956_4 PFAM Transposase, IS204 IS1001 IS1096 IS1165 K07485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005251 496.0
TLS1_k127_7595956_5 Alpha/beta hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 352.0
TLS1_k127_7595956_7 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007358 248.0
TLS1_k127_7595956_8 - K07184,K07777,K12065,K13527 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000002434 212.0
TLS1_k127_7600761_0 Peptidase family M1 domain K08776 - - 8.302e-256 801.0
TLS1_k127_7600761_1 Transposase IS200 like - - - 0.0000000000000000000000000000000000009529 141.0
TLS1_k127_7600761_2 Protein of unknown function (DUF433) - - - 0.000000000000000000001718 95.0
TLS1_k127_7600761_3 HDOD domain - - - 0.00000000000000008583 81.0
TLS1_k127_7600761_4 Transposase IS200 like - - - 0.00000000000008185 71.0
TLS1_k127_7600761_5 HDOD domain - - - 0.0000000000001302 81.0
TLS1_k127_7600761_6 GDSL-like Lipase/Acylhydrolase - - - 0.0000000001823 73.0
TLS1_k127_7600761_7 HDOD domain - - - 0.00001992 49.0
TLS1_k127_7600761_8 HDOD domain - - - 0.0001088 45.0
TLS1_k127_7605056_0 NmrA-like family K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 561.0
TLS1_k127_7605056_1 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 461.0
TLS1_k127_7605056_2 Carotenoid biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 379.0
TLS1_k127_7605056_3 Metallo-peptidase family M12B Reprolysin-like - - - 0.0000000000000000000000000000000000000000000000000001186 206.0
TLS1_k127_7605056_4 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.00000000000000002006 87.0
TLS1_k127_7613043_0 PFAM sodium calcium exchanger membrane region K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 310.0
TLS1_k127_7613043_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000002063 149.0
TLS1_k127_7613043_2 Protein of unknown function (DUF819) - - - 0.0000489 46.0
TLS1_k127_7628171_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1665.0
TLS1_k127_7628171_1 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 8.659e-229 713.0
TLS1_k127_7628171_10 IMP dehydrogenase activity K09137 - - 0.0000000000000000000000000000000000000000004582 162.0
TLS1_k127_7628171_11 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000000000000000000000000009817 132.0
TLS1_k127_7628171_12 ATP-independent chaperone mediated protein folding - - - 0.0000000000000000000000000000003885 131.0
TLS1_k127_7628171_13 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000001635 123.0
TLS1_k127_7628171_14 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K12263 - - 0.0000000000000000000000001182 110.0
TLS1_k127_7628171_16 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000004699 91.0
TLS1_k127_7628171_17 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000005432 90.0
TLS1_k127_7628171_18 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000006545 70.0
TLS1_k127_7628171_19 Prokaryotic dksA traR C4-type zinc finger - - - 0.0000000001872 66.0
TLS1_k127_7628171_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 584.0
TLS1_k127_7628171_20 cation diffusion facilitator family transporter - - - 0.00000004551 55.0
TLS1_k127_7628171_21 YtxH-like protein - - - 0.000000303 57.0
TLS1_k127_7628171_3 PFAM SufBD protein K07033,K09014,K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 431.0
TLS1_k127_7628171_4 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 425.0
TLS1_k127_7628171_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172,K18357,K18358 - 1.2.1.58,1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002456 271.0
TLS1_k127_7628171_6 Inositol monophosphatase family K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000447 257.0
TLS1_k127_7628171_7 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001095 253.0
TLS1_k127_7628171_8 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000001973 208.0
TLS1_k127_7628171_9 transporter K07238,K11021,K16267 - - 0.000000000000000000000000000000000000000000000000000002357 197.0
TLS1_k127_762871_0 DNA ligase (ATP) activity K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007608 343.0
TLS1_k127_762871_1 PFAM ATP dependent DNA ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001611 283.0
TLS1_k127_7639417_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 404.0
TLS1_k127_7639825_0 - - - - 0.00000000000000000000000000003076 123.0
TLS1_k127_7639825_1 - - - - 0.0005146 47.0
TLS1_k127_7641169_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 - 2.4.1.321 0.0000000000000000000000000000000000000002253 152.0
TLS1_k127_7641169_1 Virulence factor BrkB K07058 - - 0.000000000000000000000001805 108.0
TLS1_k127_7693252_1 - - - - 0.0000000000000000003322 87.0
TLS1_k127_773704_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 8.713e-229 715.0
TLS1_k127_773704_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 4.599e-228 711.0
TLS1_k127_773704_2 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 508.0
TLS1_k127_773704_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 323.0
TLS1_k127_773704_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 289.0
TLS1_k127_773704_5 PFAM peptidase M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002528 239.0
TLS1_k127_773704_6 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000002119 211.0
TLS1_k127_773704_7 ORF6N domain - - - 0.0000000000000000000000000000000000000000001355 165.0
TLS1_k127_77421_0 S-adenosylhomocysteine deaminase activity - - - 3.227e-251 787.0
TLS1_k127_77421_1 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008068 279.0
TLS1_k127_77421_4 Helix-turn-helix K21498 - - 0.0007807 45.0
TLS1_k127_7749513_0 self proteolysis - - - 0.00000000000000000000000000000000000000000000000000000000000000005859 232.0
TLS1_k127_7749513_1 Protein involved in outer membrane biogenesis K07290 - - 0.0001278 45.0
TLS1_k127_7751191_0 Protein involved in outer membrane biogenesis - - - 1.845e-249 802.0
TLS1_k127_7751191_1 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 454.0
TLS1_k127_7751191_2 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 384.0
TLS1_k127_7751191_3 protein homooligomerization - - - 0.0000000000000000000000000000000000000000000000000006909 186.0
TLS1_k127_7751191_4 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000001675 185.0
TLS1_k127_7751191_5 Helix-turn-helix domain - - - 0.0000001449 55.0
TLS1_k127_7755149_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 582.0
TLS1_k127_7755149_1 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000001033 74.0
TLS1_k127_7757806_0 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000000000000000000000000000001007 134.0
TLS1_k127_7757806_1 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000003301 74.0
TLS1_k127_7757806_2 Protein of unknown function (DUF1328) - - - 0.0000000003857 62.0
TLS1_k127_7783324_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 3.538e-233 739.0
TLS1_k127_7783324_1 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 511.0
TLS1_k127_7783324_2 transposition K07497 - - 0.000001026 50.0
TLS1_k127_7803247_1 peptidase M48, Ste24p K07387 - - 0.00000000121 64.0
TLS1_k127_7854882_0 Glycosyl transferase, family 2 K07011 - - 0.0000000000000000000000007364 112.0
TLS1_k127_7854882_1 PFAM Methyltransferase type 11 - - - 0.00000000000000000000001512 108.0
TLS1_k127_7868470_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 405.0
TLS1_k127_7868470_1 response regulator K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 321.0
TLS1_k127_7868470_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000003613 263.0
TLS1_k127_7868470_3 Phage integrase family - - - 0.00000000001807 69.0
TLS1_k127_7881019_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 5.636e-237 752.0
TLS1_k127_7881019_1 Sigma-54 interaction domain K07714 - - 2.838e-209 666.0
TLS1_k127_7881019_2 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 468.0
TLS1_k127_7881019_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 435.0
TLS1_k127_7881019_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001857 279.0
TLS1_k127_7881019_5 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000009718 189.0
TLS1_k127_7881019_6 sequence-specific DNA binding - - - 0.0000000000000000000000000000004949 127.0
TLS1_k127_7881019_8 phosphorelay signal transduction system K02535 - 3.5.1.108 0.0000000000000000000000007905 109.0
TLS1_k127_7907409_0 Type ii and iii secretion system protein K02453 - - 4.529e-263 822.0
TLS1_k127_7907409_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 7.95e-224 699.0
TLS1_k127_7907409_2 Integrase core domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 426.0
TLS1_k127_7907409_3 transposase activity K07483,K07497 - - 0.00000000000000000000000000000000000000000000000007698 182.0
TLS1_k127_7907409_4 Domain of unknown function (DUF4372) - - - 0.00000000000001957 73.0
TLS1_k127_7907409_5 Integrase core domain K07497 - - 0.0000000006939 66.0
TLS1_k127_7925483_0 MacB-like periplasmic core domain K02004 - - 2.054e-255 813.0
TLS1_k127_7925483_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005606 602.0
TLS1_k127_7925483_10 crossover junction endodeoxyribonuclease activity K01160 - 3.1.22.4 0.0000000000000000000000000000000000000000000007517 175.0
TLS1_k127_7925483_11 Protein of unknown function (DUF3703) - - - 0.00000000000000000000000000000000005827 136.0
TLS1_k127_7925483_12 Regulatory protein, FmdB family - - - 0.0000000000000000000000000002069 119.0
TLS1_k127_7925483_13 response regulator - - - 0.000000000000000000000002114 106.0
TLS1_k127_7925483_14 DNA excision K02806 - - 0.00000000009083 64.0
TLS1_k127_7925483_15 transposition K07497 - - 0.00000111 51.0
TLS1_k127_7925483_2 Catalyzes the conversion of dihydroorotate to orotate K00226,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 495.0
TLS1_k127_7925483_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 464.0
TLS1_k127_7925483_4 Evidence 2b Function of strongly homologous gene K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 349.0
TLS1_k127_7925483_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 347.0
TLS1_k127_7925483_6 lipoprotein transporter activity K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 295.0
TLS1_k127_7925483_7 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003614 271.0
TLS1_k127_7925483_8 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004259 248.0
TLS1_k127_7925483_9 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000003607 239.0
TLS1_k127_7949123_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07497 - - 0.0000000000000000000000000000000000000000000000000000000002355 205.0
TLS1_k127_7949123_1 transposase activity K07483,K07497 - - 0.0000000000000000000000000000000000000000000004671 167.0
TLS1_k127_7949123_2 lipolytic protein G-D-S-L family - - - 0.000000000000000001321 100.0
TLS1_k127_7960628_0 Multicopper oxidase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 508.0
TLS1_k127_7960628_1 response regulator K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 344.0
TLS1_k127_7960628_3 Two component transcriptional regulator, LuxR family - - - 0.0000000000000000000000001891 114.0
TLS1_k127_7999651_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 582.0
TLS1_k127_7999651_1 Sigma-54 interaction domain K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 427.0
TLS1_k127_7999651_2 PFAM Di-trans-poly-cis-decaprenylcistransferase-like K00806 - 2.5.1.31 0.0000000000005248 69.0
TLS1_k127_7999651_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K10936,K16079 - - 0.00000000002117 75.0
TLS1_k127_7999651_4 Hemerythrin - - - 0.000000000313 69.0
TLS1_k127_7999651_5 Domain of unknown function (DUF1989) K09967 - - 0.0000001375 53.0
TLS1_k127_7999651_6 NADPH:quinone reductase activity - - - 0.0001924 46.0
TLS1_k127_8008766_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 322.0
TLS1_k127_8008766_1 PLD-like domain - - - 0.000000000000000000000000000000000000000008872 155.0
TLS1_k127_8015564_0 Transposase - - - 0.0000000000000000000000000000000004258 144.0
TLS1_k127_8053_0 Histidine kinase A domain protein - - - 0.000000000002031 69.0
TLS1_k127_8063191_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003213 283.0
TLS1_k127_8063627_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 585.0
TLS1_k127_8063627_1 bacterial (prokaryotic) histone like domain K04764 - - 0.0000000000000000000000000000000000000000000001169 168.0
TLS1_k127_8063627_2 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000375 102.0
TLS1_k127_8082196_0 DNA methylase N-4 - - - 0.0 1019.0
TLS1_k127_8082196_1 Domain of unknown function (DUF3560) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001862 273.0
TLS1_k127_8082196_10 DNA binding - - - 0.00000000000000000000000000000001168 138.0
TLS1_k127_8082196_11 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 2.7.7.7 0.000000000000000000000000000109 127.0
TLS1_k127_8082196_12 Phage Mu protein F like protein - - - 0.00000000000000000000008294 110.0
TLS1_k127_8082196_13 Protein of unknown function (DUF3383) - - - 0.00000000000000000003461 104.0
TLS1_k127_8082196_14 Mazg nucleotide pyrophosphohydrolase - - - 0.000000000000000000117 96.0
TLS1_k127_8082196_15 sporulation resulting in formation of a cellular spore K06412 - - 0.0000000000000000007532 91.0
TLS1_k127_8082196_16 hydrolase activity, hydrolyzing N-glycosyl compounds K09935 - - 0.000000000000000002762 89.0
TLS1_k127_8082196_17 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000006234 99.0
TLS1_k127_8082196_18 Pyrimidine dimer DNA glycosylase - - - 0.000000000000000007826 89.0
TLS1_k127_8082196_19 DNA recombination - - - 0.00000000000000001453 91.0
TLS1_k127_8082196_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000349 240.0
TLS1_k127_8082196_21 Protein of unknown function (DUF3277) - - - 0.00000000000000006903 85.0
TLS1_k127_8082196_23 Protein of unknown function (DUF1073) K09961 - - 0.0000000000000001799 93.0
TLS1_k127_8082196_24 - - - - 0.0000000000000004814 87.0
TLS1_k127_8082196_25 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group - - - 0.000000000000000531 85.0
TLS1_k127_8082196_26 - - - - 0.00000000000007295 79.0
TLS1_k127_8082196_28 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000008558 78.0
TLS1_k127_8082196_29 Protein of unknown function (DUF3277) - - - 0.00000000004162 69.0
TLS1_k127_8082196_3 Uncharacterized protein conserved in bacteria (DUF2184) - - - 0.000000000000000000000000000000000000000000000000000000000001596 221.0
TLS1_k127_8082196_30 Protein of unknown function (DUF2612) - - - 0.00000000004386 70.0
TLS1_k127_8082196_31 - - - - 0.00000000147 69.0
TLS1_k127_8082196_32 GDSL-like protein - - - 0.00000000162 69.0
TLS1_k127_8082196_33 transposase activity - - - 0.000000002609 68.0
TLS1_k127_8082196_34 PFAM Metallophosphoesterase K03546 - - 0.000000003682 67.0
TLS1_k127_8082196_35 HNH endonuclease domain protein - - - 0.00000000569 67.0
TLS1_k127_8082196_36 - - - - 0.0000000118 59.0
TLS1_k127_8082196_37 - - - - 0.000000392 59.0
TLS1_k127_8082196_38 - - - - 0.0000009587 55.0
TLS1_k127_8082196_4 RNA ligase - - - 0.000000000000000000000000000000000000000000000000000000000004317 212.0
TLS1_k127_8082196_40 AAA domain K03546 - - 0.000005544 59.0
TLS1_k127_8082196_41 Baseplate assembly protein - - - 0.000007593 56.0
TLS1_k127_8082196_43 - - - - 0.0003244 48.0
TLS1_k127_8082196_44 - - - - 0.0003683 45.0
TLS1_k127_8082196_45 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0009216 50.0
TLS1_k127_8082196_5 - - - - 0.00000000000000000000000000000000000000000002241 169.0
TLS1_k127_8082196_6 homolog of phage Mu protein gp47 - - - 0.0000000000000000000000000000000000000000002235 176.0
TLS1_k127_8082196_7 Uncharacterized protein conserved in bacteria (DUF2213) K09960 - - 0.00000000000000000000000000000000000000007907 168.0
TLS1_k127_8082196_8 tape measure - - - 0.0000000000000000000000000000000000000001292 171.0
TLS1_k127_8082196_9 regulator of chromatin, subfamily a-like K14440 GO:0000278,GO:0000723,GO:0000724,GO:0000725,GO:0000726,GO:0000733,GO:0001325,GO:0001501,GO:0001525,GO:0001568,GO:0001944,GO:0002376,GO:0002520,GO:0003674,GO:0003676,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005700,GO:0005705,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006302,GO:0006310,GO:0006355,GO:0006357,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0007275,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009378,GO:0009653,GO:0009790,GO:0009888,GO:0009889,GO:0009987,GO:0010171,GO:0010172,GO:0010468,GO:0010556,GO:0010709,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030097,GO:0030491,GO:0031297,GO:0031323,GO:0031326,GO:0031974,GO:0031981,GO:0032200,GO:0032392,GO:0032501,GO:0032502,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0035239,GO:0035295,GO:0035861,GO:0036292,GO:0036310,GO:0040007,GO:0042592,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044464,GO:0045002,GO:0045003,GO:0045005,GO:0046483,GO:0048513,GO:0048514,GO:0048534,GO:0048589,GO:0048598,GO:0048646,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051216,GO:0051252,GO:0051276,GO:0051716,GO:0060249,GO:0060255,GO:0061306,GO:0061448,GO:0065007,GO:0065008,GO:0070013,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0072358,GO:0072359,GO:0080090,GO:0090304,GO:0090656,GO:0090734,GO:0090737,GO:0097159,GO:0097617,GO:0098687,GO:0140097,GO:1901360,GO:1901363,GO:1901576,GO:1903506,GO:1990163,GO:2000112,GO:2001141 3.6.4.12 0.000000000000000000000000000000002233 148.0
TLS1_k127_8082197_0 DNA packaging protein gp2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 509.0
TLS1_k127_8082197_1 Phage P22-like portal protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 418.0
TLS1_k127_8082197_10 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.00000000000000000000000000000000000008814 149.0
TLS1_k127_8082197_11 Right handed beta helix region - - - 0.000000000000000000000000000000000001208 153.0
TLS1_k127_8082197_13 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.00000000000000000000000000000001682 136.0
TLS1_k127_8082197_14 - - - - 0.000000000000000000000000000004136 123.0
TLS1_k127_8082197_17 - - - - 0.00000000000000000000003183 112.0
TLS1_k127_8082197_18 - - - - 0.0000000000000000000341 98.0
TLS1_k127_8082197_19 uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000005935 93.0
TLS1_k127_8082197_2 Protein of unknown function (DUF4043) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 309.0
TLS1_k127_8082197_20 - - - - 0.00000000000000441 78.0
TLS1_k127_8082197_22 - K12056 - - 0.0000000008312 71.0
TLS1_k127_8082197_23 - - - - 0.00000000357 66.0
TLS1_k127_8082197_24 - - - - 0.000000172 61.0
TLS1_k127_8082197_25 - - - - 0.0000003194 55.0
TLS1_k127_8082197_28 Transglycosylase SLT domain K08307 - - 0.0004558 53.0
TLS1_k127_8082197_29 Belongs to the helicase family. UvrD subfamily - - - 0.0008219 51.0
TLS1_k127_8082197_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 298.0
TLS1_k127_8082197_4 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001246 282.0
TLS1_k127_8082197_5 TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003625 268.0
TLS1_k127_8082197_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002106 244.0
TLS1_k127_8082197_7 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000001388 231.0
TLS1_k127_8082197_8 PFAM Glycosyl transferase, family 8 - - - 0.00000000000000000000000000000000000000000000000000000000004605 218.0
TLS1_k127_8082197_9 D12 class N6 adenine-specific DNA methyltransferase - - - 0.000000000000000000000000000000000000000000000000000003776 198.0
TLS1_k127_814359_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002501 232.0
TLS1_k127_814359_1 - - - - 0.00000000000000002345 85.0
TLS1_k127_826832_0 Elements of external origin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 479.0
TLS1_k127_826832_1 Nacht domain - - - 0.000000006998 61.0
TLS1_k127_83002_0 dipeptide transport K02035 - - 8.677e-200 629.0
TLS1_k127_83002_1 nitrogen compound transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 460.0
TLS1_k127_83002_2 ABC transporter permease K02034 - - 0.000000000000000000000002957 112.0
TLS1_k127_84047_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 3.146e-259 805.0
TLS1_k127_84047_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 5.34e-244 761.0
TLS1_k127_84047_10 inositol monophosphate 1-phosphatase activity K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000002881 259.0
TLS1_k127_84047_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002024 245.0
TLS1_k127_84047_12 cell redox homeostasis - - - 0.0000000000000000000000000000000000000000000000000000000000001538 216.0
TLS1_k127_84047_13 peptide-methionine (S)-S-oxide reductase activity K07304,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000001139 139.0
TLS1_k127_84047_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.189e-230 715.0
TLS1_k127_84047_3 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 538.0
TLS1_k127_84047_4 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 445.0
TLS1_k127_84047_5 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005495 424.0
TLS1_k127_84047_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 409.0
TLS1_k127_84047_7 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 409.0
TLS1_k127_84047_8 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 348.0
TLS1_k127_84047_9 Tetratricopeptide repeat K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 306.0
TLS1_k127_84671_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 321.0
TLS1_k127_84671_1 Product type r regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002754 259.0
TLS1_k127_84671_2 response regulator K02479,K07684,K07685 - - 0.0000000005743 66.0
TLS1_k127_84671_3 Response regulator, receiver - - - 0.0000002722 58.0
TLS1_k127_85192_0 Anti-sigma-K factor rskA K18682 - - 0.00000000000000000000000000000000000000000004194 169.0
TLS1_k127_85192_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000168 164.0
TLS1_k127_85192_2 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.000000000000000000000000000000000000000002492 158.0
TLS1_k127_865004_0 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006627 419.0
TLS1_k127_865004_1 Ion transport protein K10716 - - 0.0000000000000002848 79.0
TLS1_k127_865004_2 Site-specific recombinase, phage integrase family - - - 0.00002032 49.0
TLS1_k127_88544_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.454e-267 824.0
TLS1_k127_88544_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.425e-199 629.0
TLS1_k127_88544_10 - - - - 0.00000000108 70.0
TLS1_k127_88544_11 Tetratricopeptide TPR_2 repeat protein - - - 0.00000007363 64.0
TLS1_k127_88544_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004538 560.0
TLS1_k127_88544_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 507.0
TLS1_k127_88544_4 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 307.0
TLS1_k127_88544_5 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000001505 243.0
TLS1_k127_88544_6 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - - 0.000000000000000000000000000000000000000000000000000000000004414 209.0
TLS1_k127_88544_7 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000000000000000000000000000000000006279 181.0
TLS1_k127_88544_8 Binds the 23S rRNA K02909 - - 0.000000000000000000000000000000000001844 138.0
TLS1_k127_88544_9 YCII-related domain K05527,K09780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000003386 84.0
TLS1_k127_90017_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 8.934e-242 759.0
TLS1_k127_90017_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07263 - - 9.756e-210 664.0
TLS1_k127_90017_2 Aminotransferase class-III K01845 - 5.4.3.8 1.634e-209 658.0
TLS1_k127_90017_3 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 429.0
TLS1_k127_90017_4 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 366.0
TLS1_k127_90017_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 347.0
TLS1_k127_90017_7 (Barnase) inhibitor - - - 0.0000000000000000000000000000000000000000007591 163.0
TLS1_k127_90017_9 endoribonuclease activity K03628,K15125 GO:0005575,GO:0005576 - 0.000000000000000000000000000002334 126.0
TLS1_k127_959485_0 Peptide ABC transporter permease K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001189 256.0
TLS1_k127_959485_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000007195 81.0
TLS1_k127_959485_2 transcriptional regulator K03556 - - 0.00000000000001016 77.0
TLS1_k127_984960_0 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 319.0
TLS1_k127_984960_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 297.0
TLS1_k127_984960_10 DSBA-like thioredoxin domain - - - 0.0000000114 57.0
TLS1_k127_984960_2 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 291.0
TLS1_k127_984960_3 nitric oxide reductase activity K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000005117 256.0
TLS1_k127_984960_4 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000004173 178.0
TLS1_k127_984960_5 Protein of unknown function (DUF2442) - - - 0.0000000000000000000000000000000000001748 141.0
TLS1_k127_984960_6 Domain of unknown function (DUF4160) - - - 0.0000000000000000000007248 94.0
TLS1_k127_984960_7 Domain of unknown function (DUF4160) - - - 0.0000000000000003119 78.0
TLS1_k127_984960_8 NUMOD4 motif - - - 0.00000000007817 71.0
TLS1_k127_984960_9 hydrolase activity, acting on ester bonds - - - 0.0000000007156 62.0
TLS1_k127_988824_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 608.0
TLS1_k127_988824_1 Evidence 2b Function of strongly homologous gene K01740,K03430,K05306,K09469 GO:0003674,GO:0003824 2.5.1.49,2.6.1.37,3.11.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 568.0
TLS1_k127_988824_10 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000005596 56.0
TLS1_k127_988824_2 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 530.0
TLS1_k127_988824_3 lysyltransferase activity K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 401.0
TLS1_k127_988824_4 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 383.0
TLS1_k127_988824_5 Belongs to the TPP enzyme family K09459 - 4.1.1.82 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008651 355.0
TLS1_k127_988824_6 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K09459 - 4.1.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008592 277.0
TLS1_k127_988824_9 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000003771 58.0
TLS1_k127_988929_0 peptidyl-tyrosine sulfation - - - 1.563e-201 680.0
TLS1_k127_988929_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 454.0
TLS1_k127_988929_2 Mitochondrial biogenesis AIM24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 400.0
TLS1_k127_988929_3 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 323.0
TLS1_k127_988929_4 Domain of unknown function (DUF3332) - - - 0.0000000000003074 74.0