Overview

ID MAG03974
Name TLS1_bin.16
Sample SMP0103
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Rhizobiales
Family Aestuariivirgaceae
Genus DATBLQ01
Species
Assembly information
Completeness (%) 90.31
Contamination (%) 3.28
GC content (%) 60.0
N50 (bp) 43,242
Genome size (bp) 3,094,461

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2928

Gene name Description KEGG GOs EC E-value Score Sequence
TLS1_k127_1030554_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1238.0
TLS1_k127_1030554_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0 1073.0
TLS1_k127_1030554_10 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009737 498.0
TLS1_k127_1030554_11 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038,K21977 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005808 496.0
TLS1_k127_1030554_12 Lytic murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 488.0
TLS1_k127_1030554_13 Histidine kinase K15011 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 458.0
TLS1_k127_1030554_14 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 456.0
TLS1_k127_1030554_15 Enoyl-(Acyl carrier protein) reductase K00208 GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 422.0
TLS1_k127_1030554_16 ThiF family K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 350.0
TLS1_k127_1030554_17 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006425 340.0
TLS1_k127_1030554_18 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 335.0
TLS1_k127_1030554_19 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 339.0
TLS1_k127_1030554_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.169e-267 846.0
TLS1_k127_1030554_20 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 334.0
TLS1_k127_1030554_21 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 316.0
TLS1_k127_1030554_22 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 286.0
TLS1_k127_1030554_23 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000605 281.0
TLS1_k127_1030554_24 PFAM response regulator receiver K15012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006684 276.0
TLS1_k127_1030554_25 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001358 264.0
TLS1_k127_1030554_26 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003113 257.0
TLS1_k127_1030554_27 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000258 228.0
TLS1_k127_1030554_28 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000000000000000000001603 226.0
TLS1_k127_1030554_29 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000000003067 202.0
TLS1_k127_1030554_3 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 3.523e-227 713.0
TLS1_k127_1030554_30 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000000000000000001284 198.0
TLS1_k127_1030554_31 Bacterial SH3 domain K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000003458 198.0
TLS1_k127_1030554_32 DNA repair protein MmcB-like - - - 0.0000000000000000000000000000000000000000000003748 172.0
TLS1_k127_1030554_33 Belongs to the Fur family K09826 - - 0.0000000000000000000000000000000000000000000007103 169.0
TLS1_k127_1030554_34 Protein of unknown function (DUF448) K07742 - - 0.000000000000000000000000000000000000004493 154.0
TLS1_k127_1030554_35 Cro/C1-type HTH DNA-binding domain - - - 0.000000000000000000000000000000000001253 142.0
TLS1_k127_1030554_36 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000003668 138.0
TLS1_k127_1030554_37 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000005507 134.0
TLS1_k127_1030554_38 Ribosomal protein S20 K02968 - - 0.00000000000000000003166 92.0
TLS1_k127_1030554_39 Cupin domain - - - 0.000000000000000009958 91.0
TLS1_k127_1030554_4 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 1.144e-213 684.0
TLS1_k127_1030554_42 UPF0391 membrane protein - - - 0.000000001255 62.0
TLS1_k127_1030554_43 Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD) - GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006029,GO:0006082,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0030166,GO:0030203,GO:0030204,GO:0030206,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044272,GO:0044281,GO:0044464,GO:0050650,GO:0050654,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903510 - 0.000005699 56.0
TLS1_k127_1030554_5 Beta-ketoacyl synthase, C-terminal domain K00647 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 1.167e-202 638.0
TLS1_k127_1030554_6 TIGRFAM polyhydroxyalkanoate depolymerase, intracellular K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 546.0
TLS1_k127_1030554_7 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 542.0
TLS1_k127_1030554_8 D-isomer specific 2-hydroxyacid dehydrogenase K00015 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000043 526.0
TLS1_k127_1030554_9 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 527.0
TLS1_k127_1074648_0 Family membership - - - 4.34e-278 884.0
TLS1_k127_1074648_1 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000326 108.0
TLS1_k127_1074648_2 - - - - 0.0000000000000000000003049 105.0
TLS1_k127_1076420_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 601.0
TLS1_k127_1076420_2 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000001412 223.0
TLS1_k127_1110849_0 56kDa selenium binding protein (SBP56) K17285 - - 1.429e-268 830.0
TLS1_k127_1110849_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 7.19e-244 764.0
TLS1_k127_1110849_10 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 472.0
TLS1_k127_1110849_11 phosphate transport system permease K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 473.0
TLS1_k127_1110849_12 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 452.0
TLS1_k127_1110849_13 PFAM ABC transporter related K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 447.0
TLS1_k127_1110849_14 beta-keto acid cleavage enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 426.0
TLS1_k127_1110849_15 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 429.0
TLS1_k127_1110849_16 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 407.0
TLS1_k127_1110849_17 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 382.0
TLS1_k127_1110849_18 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009734 378.0
TLS1_k127_1110849_19 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007157 357.0
TLS1_k127_1110849_2 Pyridine nucleotide-disulphide oxidoreductase K05297 - 1.18.1.1 1.782e-221 698.0
TLS1_k127_1110849_20 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 344.0
TLS1_k127_1110849_21 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 343.0
TLS1_k127_1110849_22 ABC-type transport system, periplasmic component surface lipoprotein K02058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000058 344.0
TLS1_k127_1110849_23 PFAM ATP-binding region ATPase domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 344.0
TLS1_k127_1110849_24 Domain of unknown function (DUF1989) K09967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 331.0
TLS1_k127_1110849_25 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 334.0
TLS1_k127_1110849_26 Transcriptional regulatory protein, C terminal K07657 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 328.0
TLS1_k127_1110849_27 Phytochelatin synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 292.0
TLS1_k127_1110849_28 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 285.0
TLS1_k127_1110849_29 Fatty acid desaturase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002964 276.0
TLS1_k127_1110849_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 2.978e-218 693.0
TLS1_k127_1110849_30 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001613 269.0
TLS1_k127_1110849_31 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001612 265.0
TLS1_k127_1110849_32 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000001942 252.0
TLS1_k127_1110849_33 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003067 251.0
TLS1_k127_1110849_34 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003278 244.0
TLS1_k127_1110849_35 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000282 249.0
TLS1_k127_1110849_36 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001227 228.0
TLS1_k127_1110849_37 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000003432 202.0
TLS1_k127_1110849_38 SNARE associated golgi protein - - - 0.00000000000000000000000000000000000000000000000000005853 197.0
TLS1_k127_1110849_39 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000001812 189.0
TLS1_k127_1110849_4 COG0402 Cytosine deaminase and related metal-dependent hydrolases K18456 - 3.5.4.32 4.064e-208 656.0
TLS1_k127_1110849_40 Cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000001372 168.0
TLS1_k127_1110849_41 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000006751 163.0
TLS1_k127_1110849_42 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000003042 153.0
TLS1_k127_1110849_43 Protein of unknown function (DUF805) - - - 0.0000000000000000000000000000000000001425 146.0
TLS1_k127_1110849_44 Response regulator receiver - - - 0.0000000000000000000000000000000000002013 147.0
TLS1_k127_1110849_45 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000000000000000002035 115.0
TLS1_k127_1110849_46 DoxX K15977 - - 0.000000000000000000000001604 108.0
TLS1_k127_1110849_47 Dodecin K09165 - - 0.00000000000000000007589 103.0
TLS1_k127_1110849_48 Response regulator receiver - - - 0.000000000000000003213 89.0
TLS1_k127_1110849_49 Dak1 domain K05878 - 2.7.1.121 0.000000000000001011 79.0
TLS1_k127_1110849_5 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006975 582.0
TLS1_k127_1110849_50 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000002089 71.0
TLS1_k127_1110849_51 Transmembrane secretion effector - - - 0.0000003057 58.0
TLS1_k127_1110849_6 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 582.0
TLS1_k127_1110849_7 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 557.0
TLS1_k127_1110849_8 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003619 544.0
TLS1_k127_1110849_9 Aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 517.0
TLS1_k127_1113225_0 COG0174 Glutamine synthetase K01915 - 6.3.1.2 1.375e-257 800.0
TLS1_k127_1113225_1 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 1.982e-243 762.0
TLS1_k127_1113225_10 P pilus assembly protein porin PapC K07347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 516.0
TLS1_k127_1113225_11 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 490.0
TLS1_k127_1113225_12 -glutamine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006871 455.0
TLS1_k127_1113225_13 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 453.0
TLS1_k127_1113225_14 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K00830,K00839,K03430 GO:0003674,GO:0003824 2.6.1.112,2.6.1.37,2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 415.0
TLS1_k127_1113225_15 Binding-protein-dependent transport system inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004044 396.0
TLS1_k127_1113225_16 GXGXG motif K22082 - 2.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 389.0
TLS1_k127_1113225_17 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 383.0
TLS1_k127_1113225_18 Na+/Pi-cotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 376.0
TLS1_k127_1113225_19 overlaps another CDS with the same product name K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 349.0
TLS1_k127_1113225_2 belongs to the aldehyde dehydrogenase family - - - 6.672e-230 719.0
TLS1_k127_1113225_20 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 295.0
TLS1_k127_1113225_21 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 286.0
TLS1_k127_1113225_22 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.0000000000000000000000000000000000000000000000000000000000000000000001047 251.0
TLS1_k127_1113225_23 GntR family K13637 - - 0.00000000000000000000000000000000000000000000000000000002691 206.0
TLS1_k127_1113225_24 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.0000000000000000000000000000000000000000000000002232 190.0
TLS1_k127_1113225_25 Spore Coat Protein U domain - - - 0.000000000000000000000005772 109.0
TLS1_k127_1113225_26 EamA-like transporter family - - - 0.000002425 59.0
TLS1_k127_1113225_27 Spore Coat Protein U domain - - - 0.00001114 53.0
TLS1_k127_1113225_3 FAD dependent oxidoreductase - - - 3.633e-220 692.0
TLS1_k127_1113225_4 Conserved region in glutamate synthase K22083 - 2.1.1.21 3.137e-217 682.0
TLS1_k127_1113225_5 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 3.879e-196 625.0
TLS1_k127_1113225_6 III protein, CoA-transferase family K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 539.0
TLS1_k127_1113225_7 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 536.0
TLS1_k127_1113225_8 Bacterial extracellular solute-binding protein K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 526.0
TLS1_k127_1113225_9 PFAM type I phosphodiesterase nucleotide pyrophosphatase K19670 - 3.11.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 524.0
TLS1_k127_1132126_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00169,K03737 - 1.2.7.1 8.111e-223 701.0
TLS1_k127_1142931_0 L,D-transpeptidase catalytic domain K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 316.0
TLS1_k127_1142931_1 Spermidine putrescine-binding periplasmic protein K11073 - - 0.0000000000000000000000000000000000000000000000000000000000000000001578 239.0
TLS1_k127_1142931_2 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000126 225.0
TLS1_k127_1142931_3 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000009207 171.0
TLS1_k127_1142931_4 Protein of unknown function (DUF992) - - - 0.0000000000000000000000000000000000000003736 154.0
TLS1_k127_1142931_5 Opacity family porin protein - - - 0.00000000004718 72.0
TLS1_k127_1143078_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.152e-307 954.0
TLS1_k127_1143078_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 8.036e-282 882.0
TLS1_k127_1143078_10 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000806 406.0
TLS1_k127_1143078_11 YmdB-like protein K09769 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 385.0
TLS1_k127_1143078_12 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 357.0
TLS1_k127_1143078_13 MotA/TolQ/ExbB proton channel family K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008889 289.0
TLS1_k127_1143078_14 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 299.0
TLS1_k127_1143078_15 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 295.0
TLS1_k127_1143078_16 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000005284 239.0
TLS1_k127_1143078_17 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000000000000000000000005157 205.0
TLS1_k127_1143078_18 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000155 197.0
TLS1_k127_1143078_19 biopolymer transport protein K03559,K03560 - - 0.000000000000000000000000000000000000000000000000004382 185.0
TLS1_k127_1143078_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 2.646e-236 744.0
TLS1_k127_1143078_20 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000000005363 185.0
TLS1_k127_1143078_21 Protein conserved in bacteria K20444 - - 0.0000000000000000000000000000000000000000002371 168.0
TLS1_k127_1143078_22 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000003063 173.0
TLS1_k127_1143078_23 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000138 166.0
TLS1_k127_1143078_24 TIGRFAM acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.000000000000000000000000000000000000000002399 165.0
TLS1_k127_1143078_25 PIN domain - - - 0.00000000000000000000000000000000000000003899 155.0
TLS1_k127_1143078_26 Cell division and transport-associated protein TolA K03646 - - 0.000000000000000000000000000000000000000404 161.0
TLS1_k127_1143078_27 Tetratricopeptide repeat - - - 0.0000000000000000000000000000005998 137.0
TLS1_k127_1143078_28 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000005788 119.0
TLS1_k127_1143078_29 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000001032 107.0
TLS1_k127_1143078_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 3.328e-213 669.0
TLS1_k127_1143078_30 Outer membrane protein beta-barrel domain - - - 0.000000000000001471 84.0
TLS1_k127_1143078_31 Passenger-associated-transport-repeat - - - 0.00000000000005596 84.0
TLS1_k127_1143078_32 PFAM type IV pilus assembly PilZ - - - 0.00001608 50.0
TLS1_k127_1143078_33 Cysteine-rich secretory protein family - - - 0.00001881 53.0
TLS1_k127_1143078_35 - - - - 0.0003443 44.0
TLS1_k127_1143078_36 secreted protein - - - 0.0004427 51.0
TLS1_k127_1143078_37 SpoVT / AbrB like domain - - - 0.0009656 49.0
TLS1_k127_1143078_4 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 5.5e-201 634.0
TLS1_k127_1143078_5 Involved in the TonB-independent uptake of proteins K03641 - - 2.951e-197 623.0
TLS1_k127_1143078_6 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 529.0
TLS1_k127_1143078_7 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 520.0
TLS1_k127_1143078_8 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 497.0
TLS1_k127_1143078_9 Belongs to the phosphoglycerate kinase family K00927 GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 500.0
TLS1_k127_1156789_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1433.0
TLS1_k127_1156789_1 FAD dependent oxidoreductase central domain K19191 - 1.5.3.19 0.0 1149.0
TLS1_k127_1156789_10 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 298.0
TLS1_k127_1156789_11 HD phosphohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 293.0
TLS1_k127_1156789_12 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000107 284.0
TLS1_k127_1156789_13 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001456 273.0
TLS1_k127_1156789_14 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000007856 261.0
TLS1_k127_1156789_15 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001529 254.0
TLS1_k127_1156789_16 Branched-chain amino acid ATP-binding cassette transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000644 239.0
TLS1_k127_1156789_17 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000481 219.0
TLS1_k127_1156789_18 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000005856 217.0
TLS1_k127_1156789_19 Hemimethylated DNA-binding protein YccV like K11940 - - 0.000000000000000000000000000000000000000000001505 167.0
TLS1_k127_1156789_2 PFAM nitrite sulfite reductase hemoprotein beta-component ferrodoxin domain protein K00366,K00381 - 1.7.7.1,1.8.1.2 5.861e-249 781.0
TLS1_k127_1156789_20 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000003066 169.0
TLS1_k127_1156789_21 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.000000000000000000000000000000000000000007564 164.0
TLS1_k127_1156789_22 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000009489 150.0
TLS1_k127_1156789_23 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000006337 128.0
TLS1_k127_1156789_24 Bacterial protein of unknown function (DUF934) - - - 0.0000000000000000000004524 103.0
TLS1_k127_1156789_25 Protein of unknown function (DUF2849) - - - 0.00000000000000001225 87.0
TLS1_k127_1156789_27 Flavinator of succinate dehydrogenase - GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006119,GO:0006121,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016043,GO:0016310,GO:0016999,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0022900,GO:0022904,GO:0033108,GO:0034552,GO:0034553,GO:0034622,GO:0034641,GO:0036211,GO:0042773,GO:0042775,GO:0043170,GO:0043412,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:0072521,GO:1901135,GO:1901360,GO:1901564 - 0.0001291 46.0
TLS1_k127_1156789_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.714e-205 654.0
TLS1_k127_1156789_4 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 496.0
TLS1_k127_1156789_5 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 409.0
TLS1_k127_1156789_6 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 389.0
TLS1_k127_1156789_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 387.0
TLS1_k127_1156789_8 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 349.0
TLS1_k127_1156789_9 FAD binding domain K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 313.0
TLS1_k127_119934_0 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 595.0
TLS1_k127_119934_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 566.0
TLS1_k127_119934_10 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 290.0
TLS1_k127_119934_11 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000271 277.0
TLS1_k127_119934_12 Metal dependent phosphohydrolases with conserved 'HD' motif. K06952 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001899 261.0
TLS1_k127_119934_13 Aminomethyltransferase folate-binding domain K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000004654 229.0
TLS1_k127_119934_14 SOS response associated peptidase (SRAP) - - - 0.000000000000000000000000000000000000000000000000000000000004651 216.0
TLS1_k127_119934_15 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000005761 162.0
TLS1_k127_119934_16 protein tyrosine phosphatase - - - 0.0000000000000000000000000000000000000006863 163.0
TLS1_k127_119934_17 PFAM glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000114 126.0
TLS1_k127_119934_18 NUDIX domain - - - 0.000000000000000000000000005781 115.0
TLS1_k127_119934_19 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000000000001123 108.0
TLS1_k127_119934_2 FAD linked oxidases, C-terminal domain K00102 GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016053,GO:0016491,GO:0016614,GO:0016898,GO:0019249,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0030447,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046394,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0072330,GO:0097159,GO:0099615,GO:1901265,GO:1901363,GO:1901576,GO:1901615,GO:1901617 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 571.0
TLS1_k127_119934_20 17 kDa outer membrane surface antigen - - - 0.0000000000000000000000001357 117.0
TLS1_k127_119934_21 - - - - 0.00000000000000002198 87.0
TLS1_k127_119934_3 Zinc-binding dehydrogenase K00001,K19745 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 441.0
TLS1_k127_119934_4 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 423.0
TLS1_k127_119934_5 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 409.0
TLS1_k127_119934_6 PFAM Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 380.0
TLS1_k127_119934_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 341.0
TLS1_k127_119934_8 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 327.0
TLS1_k127_119934_9 glycosylase i K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 300.0
TLS1_k127_1206291_0 ABC transporter transmembrane region K02021 - - 0.0 1107.0
TLS1_k127_1206291_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 2.31e-302 944.0
TLS1_k127_1206291_10 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 401.0
TLS1_k127_1206291_11 Protein of unknown function (DUF3095) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 395.0
TLS1_k127_1206291_12 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002507 248.0
TLS1_k127_1206291_13 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000008113 233.0
TLS1_k127_1206291_14 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000699 206.0
TLS1_k127_1206291_15 FecR protein - - - 0.0000000000000000000000000000000000000000004344 169.0
TLS1_k127_1206291_16 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000001322 151.0
TLS1_k127_1206291_17 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000001988 139.0
TLS1_k127_1206291_18 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0004933 52.0
TLS1_k127_1206291_2 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K13896,K15583 - - 8.168e-289 899.0
TLS1_k127_1206291_3 Adenylate cyclase K01768 - 4.6.1.1 6.049e-220 696.0
TLS1_k127_1206291_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 1.436e-210 662.0
TLS1_k127_1206291_5 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005193 594.0
TLS1_k127_1206291_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 576.0
TLS1_k127_1206291_7 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 551.0
TLS1_k127_1206291_8 glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 437.0
TLS1_k127_1206291_9 Polysaccharide lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 417.0
TLS1_k127_1221183_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 2.406e-292 912.0
TLS1_k127_1221183_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 1.213e-208 668.0
TLS1_k127_1221183_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 8.583e-203 637.0
TLS1_k127_1221183_3 Multicopper oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 510.0
TLS1_k127_1221183_4 transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 391.0
TLS1_k127_1221183_5 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 345.0
TLS1_k127_1221183_6 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000002872 174.0
TLS1_k127_1221183_7 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0000000000000000000000000007661 115.0
TLS1_k127_1221183_8 Family of unknown function (DUF5343) - - - 0.00000000000000000000000003579 109.0
TLS1_k127_1221183_9 GIY-YIG catalytic domain K07461 - - 0.0000000000000000000003241 101.0
TLS1_k127_1232671_0 glutamate synthase K00265 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 0.0 2265.0
TLS1_k127_1232671_1 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 1.3e-233 733.0
TLS1_k127_1232671_11 COG0790 FOG TPR repeat, SEL1 subfamily K07126,K13582 - - 0.0001665 45.0
TLS1_k127_1232671_2 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 397.0
TLS1_k127_1232671_3 PFAM N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 310.0
TLS1_k127_1232671_4 Serine aminopeptidase, S33 K01048 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 292.0
TLS1_k127_1232671_5 Inositol monophosphatase K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.00000000000000000000000000000000000000000000000000000000000000000000000002206 258.0
TLS1_k127_1232671_6 response regulator receiver K13589 - - 0.000000000000000000000000000000000000000000000000000001381 193.0
TLS1_k127_1232671_7 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.000000000000000000000000000000000000000000000000000001972 194.0
TLS1_k127_1232671_8 Protein of unknown function (DUF459) K09795 - - 0.0000000000000000000000000000000000000001739 166.0
TLS1_k127_1232671_9 Dehydrogenase K05711 - 1.3.1.87 0.0000000000000000000000000000009036 125.0
TLS1_k127_1301490_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1309.0
TLS1_k127_1301490_1 Amidase K02433 - 6.3.5.6,6.3.5.7 2.2e-236 738.0
TLS1_k127_1301490_10 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000003505 126.0
TLS1_k127_1301490_11 LysE type translocator - - - 0.000000000000000000000000000002059 130.0
TLS1_k127_1301490_12 endoribonuclease L-PSP - - - 0.000000000000000000000001481 108.0
TLS1_k127_1301490_13 MafB19-like deaminase - - - 0.000000000000000000000832 98.0
TLS1_k127_1301490_14 Cyclic nucleotide-monophosphate binding domain - - - 0.000001627 52.0
TLS1_k127_1301490_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 550.0
TLS1_k127_1301490_3 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000398 284.0
TLS1_k127_1301490_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001238 251.0
TLS1_k127_1301490_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000001079 243.0
TLS1_k127_1301490_6 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03767,K03768,K09565 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000006846 241.0
TLS1_k127_1301490_7 Single-strand binding protein family K03111 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - 0.000000000000000000000000000000000000000000000000000000000000000003557 229.0
TLS1_k127_1301490_8 Carbon monoxide dehydrogenase subunit G (CoxG) K09386 - - 0.00000000000000000000000000000000000000000000000000000001022 203.0
TLS1_k127_1301490_9 Cytidylyltransferase-like K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000006514 200.0
TLS1_k127_1465455_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.091e-272 848.0
TLS1_k127_1465455_1 PD-(D/E)XK nuclease superfamily K16898 - 3.6.4.12 9.234e-257 830.0
TLS1_k127_1465455_10 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 512.0
TLS1_k127_1465455_11 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 467.0
TLS1_k127_1465455_12 Threonylcarbamoyl adenosine biosynthesis protein TsaE K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 459.0
TLS1_k127_1465455_13 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009557 439.0
TLS1_k127_1465455_14 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 400.0
TLS1_k127_1465455_15 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 373.0
TLS1_k127_1465455_16 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 368.0
TLS1_k127_1465455_17 ABC transporter, ATP-binding protein K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 362.0
TLS1_k127_1465455_18 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 GO:0008150,GO:0042221,GO:0046677,GO:0050896 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007979 304.0
TLS1_k127_1465455_19 signal peptide peptidase SppA, 36K type K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 302.0
TLS1_k127_1465455_2 Phosphoenolpyruvate carboxykinase K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 5.348e-244 764.0
TLS1_k127_1465455_20 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 287.0
TLS1_k127_1465455_21 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003778 275.0
TLS1_k127_1465455_22 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000008619 258.0
TLS1_k127_1465455_23 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000704 231.0
TLS1_k127_1465455_24 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000007153 220.0
TLS1_k127_1465455_25 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000000000001028 217.0
TLS1_k127_1465455_26 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000002076 201.0
TLS1_k127_1465455_27 PFAM PTS system fructose subfamily IIA component K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000000007973 193.0
TLS1_k127_1465455_28 light absorption - - - 0.00000000000000000000000000000000000000000000000000008182 191.0
TLS1_k127_1465455_29 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000000000000000000002717 188.0
TLS1_k127_1465455_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 1.124e-241 754.0
TLS1_k127_1465455_30 Thioredoxin K03671 - - 0.000000000000000000000000000000000000000000000000514 176.0
TLS1_k127_1465455_31 Pentapeptide repeats (9 copies) - - - 0.0000000000000000000000000000000000000000000000008053 183.0
TLS1_k127_1465455_32 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000003285 147.0
TLS1_k127_1465455_33 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.0000000000000000000000000000003538 128.0
TLS1_k127_1465455_34 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism K06023 - - 0.0000000000000000000000000003156 122.0
TLS1_k127_1465455_35 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702 - 0.000000000000000000000000001095 114.0
TLS1_k127_1465455_36 Protein of unknown function (FYDLN_acid) - - - 0.00000000000000001388 87.0
TLS1_k127_1465455_37 Lipopolysaccharide assembly protein A domain - - - 0.00000000000000001447 91.0
TLS1_k127_1465455_38 OstA-like protein K09774 - - 0.0000000000000002856 86.0
TLS1_k127_1465455_39 Protein of unknown function (DUF1150) - - - 0.00000000002752 69.0
TLS1_k127_1465455_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 2.302e-217 679.0
TLS1_k127_1465455_40 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000002436 63.0
TLS1_k127_1465455_41 - - - - 0.0000001441 60.0
TLS1_k127_1465455_5 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 2.26e-207 681.0
TLS1_k127_1465455_6 PAS fold - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 4.279e-201 656.0
TLS1_k127_1465455_7 Histidine kinase K14980 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 3.063e-195 625.0
TLS1_k127_1465455_8 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004251 576.0
TLS1_k127_1465455_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 523.0
TLS1_k127_1467217_0 - - - - 8.543e-235 743.0
TLS1_k127_1467217_1 COG3839 ABC-type sugar transport systems, ATPase components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009549 510.0
TLS1_k127_1467217_2 ABC-type sugar transport system, permease component K02026,K17323 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 415.0
TLS1_k127_1467217_3 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006256 355.0
TLS1_k127_1637871_0 DEAD-like helicases superfamily K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 1.362e-264 832.0
TLS1_k127_1637871_1 Glutamine amidotransferase domain K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 2.979e-257 805.0
TLS1_k127_1637871_2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042,K11528 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 477.0
TLS1_k127_1637871_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K01286,K03642 - 3.4.16.4 0.000000000000002028 89.0
TLS1_k127_1637871_4 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000176 69.0
TLS1_k127_1637871_5 Sporulation domain-containing protein - - - 0.0000271 55.0
TLS1_k127_1711084_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 3.699e-285 883.0
TLS1_k127_1711084_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 2.31e-281 878.0
TLS1_k127_1711084_10 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 610.0
TLS1_k127_1711084_11 Glycolate oxidase, iron-sulfur subunit K11473 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 590.0
TLS1_k127_1711084_12 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 571.0
TLS1_k127_1711084_13 dioxygenase K00471 - 1.14.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 538.0
TLS1_k127_1711084_14 COG0665 Glycine D-amino acid oxidases (deaminating) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 514.0
TLS1_k127_1711084_15 PFAM Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 520.0
TLS1_k127_1711084_16 Alpha/beta hydrolase family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 493.0
TLS1_k127_1711084_17 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 454.0
TLS1_k127_1711084_18 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008405 412.0
TLS1_k127_1711084_19 FAD binding domain K11472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 364.0
TLS1_k127_1711084_2 enoyl-CoA hydratase isomerase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.637e-261 824.0
TLS1_k127_1711084_20 Cysteine-rich domain K18928 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 351.0
TLS1_k127_1711084_21 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 345.0
TLS1_k127_1711084_22 Histidyl-tRNA synthetase K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 315.0
TLS1_k127_1711084_23 LysR substrate binding domain K03566,K17850 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 295.0
TLS1_k127_1711084_24 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008886 271.0
TLS1_k127_1711084_25 AsmA-like C-terminal region K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000476 268.0
TLS1_k127_1711084_26 TIGRFAM maf protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001091 245.0
TLS1_k127_1711084_27 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000006572 241.0
TLS1_k127_1711084_28 LUD domain K00782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000477 246.0
TLS1_k127_1711084_29 Bacterial periplasmic substrate-binding proteins K02030 - - 0.0000000000000000000000000000000000000000000000000000000000002075 222.0
TLS1_k127_1711084_3 Glycolate oxidase subunit GlcD K00104 - 1.1.3.15 2.17e-253 788.0
TLS1_k127_1711084_30 Sel1-like repeats. K07126,K13582 - - 0.00000000000000000000000000000000000000000000000000000000008584 233.0
TLS1_k127_1711084_31 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.00000000000000000000000000000000000000000000000000000002336 199.0
TLS1_k127_1711084_32 Belongs to the UPF0262 family - - - 0.00000000000000000000000000000000000000000000000000000002975 200.0
TLS1_k127_1711084_33 Low molecular weight phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.00000000000000000000000000000000000000000000000000002693 191.0
TLS1_k127_1711084_34 COG0314 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000005044 191.0
TLS1_k127_1711084_35 Protein of unknown function (DUF2948) - - - 0.000000000000000000000000000000000000000002223 162.0
TLS1_k127_1711084_36 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000005578 144.0
TLS1_k127_1711084_37 nuclease - - - 0.00000000000000000000000000000000006014 140.0
TLS1_k127_1711084_38 Translation initiation factor 1A / IF-1 K02518 - - 0.00000000000000000000000000000000008451 134.0
TLS1_k127_1711084_39 Prophage maintenance system killer protein K07341 - - 0.0000000000000000001976 95.0
TLS1_k127_1711084_4 Trimethylamine methyltransferase K14083 - 2.1.1.250 1.006e-245 767.0
TLS1_k127_1711084_40 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000000006171 88.0
TLS1_k127_1711084_41 Fic/DOC family - - - 0.0000000000000003726 79.0
TLS1_k127_1711084_42 - - - - 0.000000000003227 74.0
TLS1_k127_1711084_43 Resolvase - - - 0.00000001436 58.0
TLS1_k127_1711084_45 Recombinase zinc beta ribbon domain - - - 0.000369 46.0
TLS1_k127_1711084_46 Phasin protein - - - 0.000718 48.0
TLS1_k127_1711084_5 Malate synthase K01638 - 2.3.3.9 5.231e-244 763.0
TLS1_k127_1711084_6 Domain of unknown function (DUF3390) K18929 - - 5.232e-224 702.0
TLS1_k127_1711084_7 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 3.997e-207 673.0
TLS1_k127_1711084_8 Thiolase, N-terminal domain K00626 GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016020,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0033554,GO:0033812,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0071944,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 2.3.1.9 2.765e-202 635.0
TLS1_k127_1711084_9 Anticodon binding domain K01892 - 6.1.1.21 1.812e-196 623.0
TLS1_k127_1736172_0 TRAP transporter, 4TM 12TM fusion protein - - - 0.0 1060.0
TLS1_k127_1736172_1 Belongs to the DegT DnrJ EryC1 family K19715 - 2.6.1.109 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 606.0
TLS1_k127_1736172_10 Domain of unknown function (DUF1850) - - - 0.000000000000000000000000000000000000000002858 172.0
TLS1_k127_1736172_11 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000001942 143.0
TLS1_k127_1736172_12 - - - - 0.000000000000000000000000001661 120.0
TLS1_k127_1736172_13 - - - - 0.000000000005922 70.0
TLS1_k127_1736172_14 Integrase core domain K07497 - - 0.000000001222 59.0
TLS1_k127_1736172_15 - - - - 0.0000001368 61.0
TLS1_k127_1736172_2 Acetamidase/Formamidase family K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 583.0
TLS1_k127_1736172_3 TRAP transporter solute receptor TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006151 496.0
TLS1_k127_1736172_4 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000001431 235.0
TLS1_k127_1736172_5 Protein tyrosine phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000003279 229.0
TLS1_k127_1736172_6 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000001029 220.0
TLS1_k127_1736172_7 Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.0000000000000000000000000000000000000000000000000000005431 204.0
TLS1_k127_1736172_8 protein, putative amidase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000003182 200.0
TLS1_k127_1736172_9 Cytochrome C oxidase, cbb3-type, subunit III K17230 - - 0.0000000000000000000000000000000000000000001902 161.0
TLS1_k127_180420_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1761.0
TLS1_k127_180420_1 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 6.2e-322 1004.0
TLS1_k127_180420_10 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 441.0
TLS1_k127_180420_11 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 413.0
TLS1_k127_180420_12 Peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 413.0
TLS1_k127_180420_13 ATPases associated with a variety of cellular activities K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001426 388.0
TLS1_k127_180420_14 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 416.0
TLS1_k127_180420_15 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 370.0
TLS1_k127_180420_16 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 349.0
TLS1_k127_180420_17 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 335.0
TLS1_k127_180420_18 FeS assembly protein SufD K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008441 317.0
TLS1_k127_180420_19 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003296 282.0
TLS1_k127_180420_2 assembly protein K09014 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - 4.347e-284 877.0
TLS1_k127_180420_20 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003952 269.0
TLS1_k127_180420_21 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004457 267.0
TLS1_k127_180420_22 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005886 256.0
TLS1_k127_180420_23 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002462 250.0
TLS1_k127_180420_24 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000001365 211.0
TLS1_k127_180420_25 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000009087 199.0
TLS1_k127_180420_26 TIGRFAM FeS assembly SUF system protein - - - 0.0000000000000000000000000000000000000000000000000000003027 195.0
TLS1_k127_180420_27 Belongs to the HesB IscA family K13628 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000223 186.0
TLS1_k127_180420_28 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000007128 198.0
TLS1_k127_180420_29 transcriptional regulator K13643 - - 0.00000000000000000000000000000000000000000000000168 177.0
TLS1_k127_180420_3 Ribonuclease E/G family K08300 - 3.1.26.12 1.258e-231 744.0
TLS1_k127_180420_30 NADH ubiquinone oxidoreductase subunit NDUFA12 K00356 - 1.6.99.3 0.0000000000000000000000000000000000000000000004038 171.0
TLS1_k127_180420_31 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000002002 160.0
TLS1_k127_180420_32 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.00000000000000000000000000000000000000000239 162.0
TLS1_k127_180420_33 COG1463 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000005867 146.0
TLS1_k127_180420_34 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000000000004322 129.0
TLS1_k127_180420_35 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000001383 121.0
TLS1_k127_180420_36 regulator of competence-specific genes K07343 - - 0.00000000000000000001788 96.0
TLS1_k127_180420_37 Outer membrane protein beta-barrel domain - - - 0.00000000000000000009479 99.0
TLS1_k127_180420_38 Opacity family porin protein K03286 - - 0.00000000002566 72.0
TLS1_k127_180420_39 Outer membrane protein beta-barrel domain - - - 0.00000000003913 71.0
TLS1_k127_180420_4 Biotin carboxylase C-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 2.281e-225 704.0
TLS1_k127_180420_40 - - - - 0.000000001376 63.0
TLS1_k127_180420_41 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0003855 43.0
TLS1_k127_180420_5 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 2.207e-202 636.0
TLS1_k127_180420_6 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 600.0
TLS1_k127_180420_7 Belongs to the DEAD box helicase family K03732,K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 554.0
TLS1_k127_180420_8 PCRF K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 497.0
TLS1_k127_180420_9 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 447.0
TLS1_k127_1844711_0 Transposase DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 374.0
TLS1_k127_1844711_1 FR47-like protein - - - 0.00000000000000000000000000000002822 128.0
TLS1_k127_185388_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0 1679.0
TLS1_k127_185388_1 AcrB/AcrD/AcrF family K18138,K18307 - - 0.0 1351.0
TLS1_k127_185388_10 Belongs to the DapA family K21062 - 3.5.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 343.0
TLS1_k127_185388_11 HlyD family secretion protein K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 314.0
TLS1_k127_185388_12 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001669 273.0
TLS1_k127_185388_13 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000001881 220.0
TLS1_k127_185388_2 Binding-protein-dependent transport system inner membrane component K02011 - - 9.817e-248 785.0
TLS1_k127_185388_3 Domain of unknown function (DUF3382) K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 553.0
TLS1_k127_185388_4 ABC-type Fe3 transport system, periplasmic component K02012,K11081 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 479.0
TLS1_k127_185388_5 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 462.0
TLS1_k127_185388_6 branched-chain amino acid K01995,K15783 GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039 3.5.4.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 413.0
TLS1_k127_185388_7 Part of the ABC transporter complex FbpABC involved in Fe(3 ) ions import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 407.0
TLS1_k127_185388_8 Oxidoreductase family, NAD-binding Rossmann fold K00035 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006813 383.0
TLS1_k127_185388_9 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 358.0
TLS1_k127_1920502_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 425.0
TLS1_k127_1920502_1 COG0845 Membrane-fusion protein K16300 - - 0.0000000000000000000000000000000000000000000000000000000000000000003488 246.0
TLS1_k127_1920502_2 acetyltransferase K03824 - - 0.00000000000000000000000000000000000000000000002472 175.0
TLS1_k127_1920502_3 cheY-homologous receiver domain - - - 0.00000000000000003055 96.0
TLS1_k127_1920502_4 PRC-barrel domain - - - 0.0000000000000005133 91.0
TLS1_k127_1974304_0 Pyruvate phosphate dikinase K01006 - 2.7.9.1 0.0 1305.0
TLS1_k127_1974304_1 Required for chromosome condensation and partitioning K03529 - - 1.316e-317 1008.0
TLS1_k127_1974304_10 Periplasmic serine proteases (ClpP class) K04773,K04774 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 292.0
TLS1_k127_1974304_11 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008988 282.0
TLS1_k127_1974304_12 May be involved in the biosynthesis of molybdopterin K03638 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000000000000000004534 256.0
TLS1_k127_1974304_13 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000001265 241.0
TLS1_k127_1974304_14 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000004248 235.0
TLS1_k127_1974304_15 Methyltransferase small domain K15460 - 2.1.1.223 0.00000000000000000000000000000000000000000000000000000000000000008018 231.0
TLS1_k127_1974304_16 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000008242 229.0
TLS1_k127_1974304_17 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000000000003729 214.0
TLS1_k127_1974304_18 Cell Wall Hydrolase - - - 0.000000000000000000000000000000000000000642 160.0
TLS1_k127_1974304_19 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.00000000000000000000000000003243 122.0
TLS1_k127_1974304_2 Thi4 family K00311 - 1.5.5.1 6.347e-262 818.0
TLS1_k127_1974304_20 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) K02109 - - 0.00000000000000000000000002582 114.0
TLS1_k127_1974304_21 Protein of unknown function (DUF721) - - - 0.00000000000000000000009521 103.0
TLS1_k127_1974304_22 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000008028 96.0
TLS1_k127_1974304_23 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000001012 90.0
TLS1_k127_1974304_24 DeoR C terminal sensor domain - - - 0.00000000000007101 74.0
TLS1_k127_1974304_25 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.000000000001126 72.0
TLS1_k127_1974304_26 Putative prokaryotic signal transducing protein - - - 0.000000000007454 73.0
TLS1_k127_1974304_3 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 2.871e-256 808.0
TLS1_k127_1974304_4 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 530.0
TLS1_k127_1974304_5 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 530.0
TLS1_k127_1974304_6 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 493.0
TLS1_k127_1974304_7 Polyprenyl synthetase K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 442.0
TLS1_k127_1974304_8 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 444.0
TLS1_k127_1974304_9 FES K03575 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 404.0
TLS1_k127_206549_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 575.0
TLS1_k127_206549_1 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 465.0
TLS1_k127_206549_10 CHASE2 - - - 0.00000000000000000004177 94.0
TLS1_k127_206549_11 Surface antigen - - - 0.00000000000000001081 93.0
TLS1_k127_206549_2 e1 component (alpha subunit) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 360.0
TLS1_k127_206549_3 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 346.0
TLS1_k127_206549_4 e3 binding domain K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 312.0
TLS1_k127_206549_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006177 283.0
TLS1_k127_206549_6 racemase activity, acting on amino acids and derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007186 248.0
TLS1_k127_206549_7 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000001257 179.0
TLS1_k127_206549_8 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000000000000000002504 142.0
TLS1_k127_206549_9 FecR protein - - - 0.0000000000000000000000000000001059 135.0
TLS1_k127_2068608_0 Sigma-70, region 4 K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 447.0
TLS1_k127_2068608_1 RNA pseudouridylate synthase K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 388.0
TLS1_k127_2068608_2 ATPases associated with a variety of cellular activities K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 341.0
TLS1_k127_2068608_3 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001292 274.0
TLS1_k127_2068608_4 ABC transporter permease K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001027 252.0
TLS1_k127_2068608_5 Outer membrane autotransporter barrel domain - - - 0.0000000000000000000000000000000000002999 161.0
TLS1_k127_2068608_6 ABC transporter substrate-binding protein K02030 - - 0.000000000000000000000000000000000008808 136.0
TLS1_k127_2074392_0 ABC transporter K02049,K15578 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007966 364.0
TLS1_k127_2074392_1 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 319.0
TLS1_k127_2074392_2 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000152 216.0
TLS1_k127_2074392_3 NAD dependent epimerase/dehydratase family - - - 0.00000000000001159 78.0
TLS1_k127_2086554_0 Bacterial NAD-glutamate dehydrogenase K15371 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 0.0 1610.0
TLS1_k127_2086554_1 FAD dependent oxidoreductase central domain K00315,K19191 - 1.5.3.19,1.5.8.4 0.0 1371.0
TLS1_k127_2086554_10 NADH:flavin oxidoreductase / NADH oxidase family K21833 - - 2.238e-225 717.0
TLS1_k127_2086554_100 - - - - 0.0006215 44.0
TLS1_k127_2086554_11 FtsX-like permease family K02004 - - 2.967e-220 710.0
TLS1_k127_2086554_12 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 5.384e-212 666.0
TLS1_k127_2086554_13 Molecular chaperone. Has ATPase activity K04079 - - 1.449e-209 669.0
TLS1_k127_2086554_14 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 4.998e-206 653.0
TLS1_k127_2086554_15 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 7.046e-201 631.0
TLS1_k127_2086554_16 PFAM Acetamidase Formamidase family K01455 - 3.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 602.0
TLS1_k127_2086554_17 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 567.0
TLS1_k127_2086554_18 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 530.0
TLS1_k127_2086554_19 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 514.0
TLS1_k127_2086554_2 Formate dehydrogenase subunit alpha - - - 0.0 1355.0
TLS1_k127_2086554_20 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 503.0
TLS1_k127_2086554_21 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 498.0
TLS1_k127_2086554_22 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 476.0
TLS1_k127_2086554_23 Domain of unknown function (DUF4175) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 496.0
TLS1_k127_2086554_24 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 465.0
TLS1_k127_2086554_25 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 445.0
TLS1_k127_2086554_26 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007463 444.0
TLS1_k127_2086554_27 electron transfer flavoprotein alpha subunit K03522 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 440.0
TLS1_k127_2086554_28 Periplasmic binding protein domain K11959 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 433.0
TLS1_k127_2086554_29 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 424.0
TLS1_k127_2086554_3 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0 1317.0
TLS1_k127_2086554_30 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 413.0
TLS1_k127_2086554_31 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 412.0
TLS1_k127_2086554_32 KR domain K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 392.0
TLS1_k127_2086554_33 COG0303 Molybdopterin biosynthesis enzyme K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 394.0
TLS1_k127_2086554_34 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 381.0
TLS1_k127_2086554_35 Belongs to the LDH2 MDH2 oxidoreductase family K13609 - 1.5.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004838 389.0
TLS1_k127_2086554_36 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 364.0
TLS1_k127_2086554_37 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 347.0
TLS1_k127_2086554_38 Transcriptional regulator, Crp Fnr family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 341.0
TLS1_k127_2086554_39 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 346.0
TLS1_k127_2086554_4 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 0.0 1030.0
TLS1_k127_2086554_40 Belongs to the urease beta subunit family K01429,K14048 - 3.5.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 340.0
TLS1_k127_2086554_41 Inhibitor of apoptosis-promoting Bax1 K06890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 333.0
TLS1_k127_2086554_42 Cytochrome C assembly protein K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005921 325.0
TLS1_k127_2086554_43 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006435 310.0
TLS1_k127_2086554_44 AAA domain, putative AbiEii toxin, Type IV TA system K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 296.0
TLS1_k127_2086554_45 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 291.0
TLS1_k127_2086554_46 ABC transporter K02003 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007423 286.0
TLS1_k127_2086554_47 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000501 276.0
TLS1_k127_2086554_48 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002567 273.0
TLS1_k127_2086554_49 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000005318 258.0
TLS1_k127_2086554_5 Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family K01428 - 3.5.1.5 8.918e-315 970.0
TLS1_k127_2086554_50 Belongs to the binding-protein-dependent transport system permease family K01998,K11961 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008363 266.0
TLS1_k127_2086554_51 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000001245 252.0
TLS1_k127_2086554_52 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000004003 250.0
TLS1_k127_2086554_53 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000003302 246.0
TLS1_k127_2086554_54 Belongs to the peptidase S11 family K01286 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000001761 254.0
TLS1_k127_2086554_55 Phosphoribosyl transferase domain K00760 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000002185 243.0
TLS1_k127_2086554_56 ABC transporter, ATP-binding protein K01996,K11963 - - 0.000000000000000000000000000000000000000000000000000000000000000000002724 241.0
TLS1_k127_2086554_57 TIGRFAM urea ABC transporter, ATP-binding protein UrtD K11962 - - 0.00000000000000000000000000000000000000000000000000000000000000000001643 241.0
TLS1_k127_2086554_58 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000001657 240.0
TLS1_k127_2086554_59 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001643 239.0
TLS1_k127_2086554_6 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 9.469e-281 876.0
TLS1_k127_2086554_60 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.0000000000000000000000000000000000000000000000000000000000000000001907 238.0
TLS1_k127_2086554_61 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000308 228.0
TLS1_k127_2086554_62 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000006778 222.0
TLS1_k127_2086554_63 Mosc domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000007061 218.0
TLS1_k127_2086554_64 PHB accumulation regulatory domain - - - 0.000000000000000000000000000000000000000000000000000000000004865 216.0
TLS1_k127_2086554_65 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000003081 212.0
TLS1_k127_2086554_66 molybdopterin-guanine dinucleotide biosynthesis protein K03753 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000003096 210.0
TLS1_k127_2086554_67 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000002624 209.0
TLS1_k127_2086554_68 Redoxin K02199 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000279 208.0
TLS1_k127_2086554_69 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000000007271 198.0
TLS1_k127_2086554_7 Adenylate cyclase - - - 5.897e-255 801.0
TLS1_k127_2086554_70 Protein of unknown function (DUF1223) - - - 0.0000000000000000000000000000000000000000000000000000009177 201.0
TLS1_k127_2086554_71 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000001047 195.0
TLS1_k127_2086554_72 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03188 - - 0.000000000000000000000000000000000000000000000000000004366 197.0
TLS1_k127_2086554_73 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000000000000000000000000000000000213 185.0
TLS1_k127_2086554_74 YHS domain protein - - - 0.000000000000000000000000000000000000000000000000115 182.0
TLS1_k127_2086554_75 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000001186 185.0
TLS1_k127_2086554_76 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000001097 180.0
TLS1_k127_2086554_77 Cell division protein K09811 - - 0.00000000000000000000000000000000000000000000002803 181.0
TLS1_k127_2086554_78 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000000000000000000000000000000000007438 179.0
TLS1_k127_2086554_79 Thioredoxin-like - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000008814 170.0
TLS1_k127_2086554_8 Putative glucoamylase - - - 2.359e-240 746.0
TLS1_k127_2086554_80 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000005212 162.0
TLS1_k127_2086554_81 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000001791 157.0
TLS1_k127_2086554_82 Protein of unknown function (DUF2794) - - - 0.0000000000000000000000000000000000003522 144.0
TLS1_k127_2086554_83 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.0000000000000000000000000000000000004777 144.0
TLS1_k127_2086554_84 tetrahydrobiopterin metabolic process K01724 - 4.2.1.96 0.00000000000000000000000000000000002622 136.0
TLS1_k127_2086554_85 COG1846 Transcriptional regulators - - - 0.0000000000000000000000000000000002093 140.0
TLS1_k127_2086554_86 - - - - 0.00000000000000000000000000000003097 131.0
TLS1_k127_2086554_87 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000001436 128.0
TLS1_k127_2086554_88 ANTAR - - - 0.0000000000000000000000000000002769 131.0
TLS1_k127_2086554_89 zinc-ribbon domain - - - 0.000000000000000000000000000001697 130.0
TLS1_k127_2086554_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00122 - 1.17.1.9 4.83e-229 729.0
TLS1_k127_2086554_90 - - - - 0.000000000000000000000000001286 116.0
TLS1_k127_2086554_91 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000001682 96.0
TLS1_k127_2086554_92 Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02003,K05685 - - 0.00000000000000000007125 91.0
TLS1_k127_2086554_93 chorismate mutase - - - 0.0000000000000003288 88.0
TLS1_k127_2086554_94 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000328 64.0
TLS1_k127_2086554_96 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000002598 65.0
TLS1_k127_2086554_98 Putative regulatory protein - - - 0.000000008293 61.0
TLS1_k127_210201_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000765 553.0
TLS1_k127_210201_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 529.0
TLS1_k127_210201_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily K15270 - - 0.00000000000000000000000000000000000000000000000000000000002828 216.0
TLS1_k127_210201_3 ornithine cyclodeaminase K01750 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 4.3.1.12 0.000000000000000000000000000000000000000000000000000000001132 209.0
TLS1_k127_210201_4 Protein of unknown function (DUF1194) - - - 0.0000000000000000000000000000000000000000000000000005491 192.0
TLS1_k127_210201_5 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000008322 171.0
TLS1_k127_210201_6 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000001401 149.0
TLS1_k127_210201_7 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000008475 144.0
TLS1_k127_210201_8 protein conserved in bacteria K09796 - - 0.00000000000000000000000000002747 123.0
TLS1_k127_210201_9 Protein of unknown function (DUF1194) - - - 0.000003141 53.0
TLS1_k127_2234717_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1069.0
TLS1_k127_2234717_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.239e-276 855.0
TLS1_k127_2234717_10 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005781 548.0
TLS1_k127_2234717_11 ABC-type sugar transport systems, permease components K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 537.0
TLS1_k127_2234717_12 TOBE domain K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 524.0
TLS1_k127_2234717_13 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008276 523.0
TLS1_k127_2234717_14 Dak1 domain K05878 - 2.7.1.121 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 466.0
TLS1_k127_2234717_15 Proline racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006146 443.0
TLS1_k127_2234717_16 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 436.0
TLS1_k127_2234717_17 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 424.0
TLS1_k127_2234717_18 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008003 446.0
TLS1_k127_2234717_19 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 421.0
TLS1_k127_2234717_2 ABC transporter substrate-binding protein K02027 - - 3.822e-247 767.0
TLS1_k127_2234717_20 ABC-type sugar transport system periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 417.0
TLS1_k127_2234717_21 Tricorn protease homolog K08676 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 419.0
TLS1_k127_2234717_22 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 412.0
TLS1_k127_2234717_23 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 382.0
TLS1_k127_2234717_24 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 387.0
TLS1_k127_2234717_25 Arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 365.0
TLS1_k127_2234717_26 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 350.0
TLS1_k127_2234717_27 Tetratricopeptide repeat K03671,K05838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 342.0
TLS1_k127_2234717_28 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 334.0
TLS1_k127_2234717_29 KR domain K13774 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 325.0
TLS1_k127_2234717_3 Belongs to the MurCDEF family - - - 1.08e-236 749.0
TLS1_k127_2234717_30 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008592 311.0
TLS1_k127_2234717_31 HemY protein N-terminus K02498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003704 320.0
TLS1_k127_2234717_32 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 297.0
TLS1_k127_2234717_33 Heparinase II/III-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 311.0
TLS1_k127_2234717_34 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 293.0
TLS1_k127_2234717_35 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001398 282.0
TLS1_k127_2234717_36 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000178 279.0
TLS1_k127_2234717_37 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002768 266.0
TLS1_k127_2234717_38 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001243 244.0
TLS1_k127_2234717_39 (twin-arginine translocation) pathway signal - - - 0.00000000000000000000000000000000000000000000000000000000000000000006607 237.0
TLS1_k127_2234717_4 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K01768 - 4.6.1.1 6.485e-226 716.0
TLS1_k127_2234717_40 Dak2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000007499 237.0
TLS1_k127_2234717_41 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001707 230.0
TLS1_k127_2234717_42 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000000000000000000000000000000005535 227.0
TLS1_k127_2234717_43 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000001919 227.0
TLS1_k127_2234717_44 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000006679 226.0
TLS1_k127_2234717_45 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000001266 220.0
TLS1_k127_2234717_46 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000000000000001699 210.0
TLS1_k127_2234717_47 Ubiquinol-cytochrome C reductase - - - 0.0000000000000000000000000000000000000000000000000000001049 198.0
TLS1_k127_2234717_48 PTS system fructose IIA component - - - 0.000000000000000000000000000000000000000000000000000000254 196.0
TLS1_k127_2234717_49 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000000000000000000000000000000000000126 198.0
TLS1_k127_2234717_5 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 2.955e-206 662.0
TLS1_k127_2234717_50 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000003425 185.0
TLS1_k127_2234717_51 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000001523 178.0
TLS1_k127_2234717_52 - - - - 0.0000000000000000000000000000000000000000281 166.0
TLS1_k127_2234717_53 Putative heavy-metal-binding - - - 0.0000000000000000000000000000000000000002566 151.0
TLS1_k127_2234717_54 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000006851 154.0
TLS1_k127_2234717_55 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000006389 152.0
TLS1_k127_2234717_56 - - - - 0.00000000000000000000000000000000002609 142.0
TLS1_k127_2234717_57 - - - - 0.00000000000000000000000000000001209 143.0
TLS1_k127_2234717_58 PTS HPr component phosphorylation site K11189 - - 0.00000000000000000000000000007953 121.0
TLS1_k127_2234717_59 Major Facilitator - - - 0.000000000000000000000000001272 128.0
TLS1_k127_2234717_6 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 6.688e-203 643.0
TLS1_k127_2234717_60 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding - - - 0.000000000000000000000001754 111.0
TLS1_k127_2234717_61 - - - - 0.000000000000000000000003076 106.0
TLS1_k127_2234717_62 - - - - 0.00000000000000001934 87.0
TLS1_k127_2234717_63 to the N-terminal domain of Lon protease K01338,K07157 - 3.4.21.53 0.000000000000201 70.0
TLS1_k127_2234717_64 ABC-type amino acid transport signal transduction systems, periplasmic component domain K02030 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464 - 0.00000000009533 63.0
TLS1_k127_2234717_65 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000005064 68.0
TLS1_k127_2234717_66 Oxidoreductase - - - 0.00000009931 59.0
TLS1_k127_2234717_67 FAD dependent oxidoreductase - - - 0.000000142 59.0
TLS1_k127_2234717_68 - - - - 0.000001389 53.0
TLS1_k127_2234717_69 - - - - 0.000002998 49.0
TLS1_k127_2234717_7 Dak1 domain K00863 - 2.7.1.28,2.7.1.29,4.6.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 587.0
TLS1_k127_2234717_70 FAD binding domain K09471 - - 0.00004519 48.0
TLS1_k127_2234717_71 - - - - 0.0004528 48.0
TLS1_k127_2234717_8 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 574.0
TLS1_k127_2234717_9 ABC-type sugar transport system, permease component K02026,K10229 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005487 548.0
TLS1_k127_2259503_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000005164 150.0
TLS1_k127_2259503_1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000000000001884 132.0
TLS1_k127_2259503_2 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000001032 91.0
TLS1_k127_2320550_0 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 490.0
TLS1_k127_2320550_1 COG0607 Rhodanese-related sulfurtransferase - - - 0.00000000000000000000000000000000000000000000004076 174.0
TLS1_k127_2320550_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.00000000000000000000000000000001547 131.0
TLS1_k127_2320550_3 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000000007017 106.0
TLS1_k127_2391642_0 Aldehyde oxidase and xanthine dehydrogenase - - - 0.0 1206.0
TLS1_k127_2391642_1 Xanthine dehydrogenase K13482 - 1.17.1.4 0.0 1026.0
TLS1_k127_2391642_10 Ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 546.0
TLS1_k127_2391642_11 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 544.0
TLS1_k127_2391642_12 ABC-type transport system, periplasmic component surface lipoprotein K02058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 539.0
TLS1_k127_2391642_13 Guanine deaminase K01487 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 541.0
TLS1_k127_2391642_14 COG0471 Di- and tricarboxylate transporters K03319,K09477,K11106,K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008994 544.0
TLS1_k127_2391642_15 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 533.0
TLS1_k127_2391642_16 Polysaccharide deacetylase K01452 - 3.5.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 508.0
TLS1_k127_2391642_17 Domain of unknown function (DUF3458_C) ARM repeats K01256 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 511.0
TLS1_k127_2391642_18 AP endonuclease family 2 C terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 507.0
TLS1_k127_2391642_19 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 487.0
TLS1_k127_2391642_2 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 3.087e-262 813.0
TLS1_k127_2391642_20 peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 488.0
TLS1_k127_2391642_21 oxidase, subunit K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 476.0
TLS1_k127_2391642_22 Oxidoreductase family, NAD-binding Rossmann fold K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 472.0
TLS1_k127_2391642_23 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 478.0
TLS1_k127_2391642_24 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 460.0
TLS1_k127_2391642_25 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 451.0
TLS1_k127_2391642_26 Belongs to the allantoicase family K01477 - 3.5.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007512 449.0
TLS1_k127_2391642_27 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase K00768 - 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 451.0
TLS1_k127_2391642_28 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 431.0
TLS1_k127_2391642_29 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 429.0
TLS1_k127_2391642_3 ABC transporter K02056 - 3.6.3.17 1.113e-232 731.0
TLS1_k127_2391642_30 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 415.0
TLS1_k127_2391642_31 Transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 418.0
TLS1_k127_2391642_32 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 397.0
TLS1_k127_2391642_33 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 369.0
TLS1_k127_2391642_34 Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 339.0
TLS1_k127_2391642_35 His Kinase A (phosphoacceptor) domain K07716 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 334.0
TLS1_k127_2391642_36 Flavin-nucleotide-binding protein K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 299.0
TLS1_k127_2391642_37 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 301.0
TLS1_k127_2391642_38 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008885 297.0
TLS1_k127_2391642_39 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004212 288.0
TLS1_k127_2391642_4 Bacterial extracellular solute-binding protein K02027 - - 1.123e-231 722.0
TLS1_k127_2391642_40 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002863 280.0
TLS1_k127_2391642_41 Enoyl-CoA hydratase/isomerase K01692,K18383 - 4.1.2.41,4.2.1.101,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001951 278.0
TLS1_k127_2391642_42 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002543 269.0
TLS1_k127_2391642_43 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000004337 248.0
TLS1_k127_2391642_44 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000006729 239.0
TLS1_k127_2391642_45 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00034 - 1.1.1.47 0.000000000000000000000000000000000000000000000000000000000000000000004677 242.0
TLS1_k127_2391642_46 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001002 250.0
TLS1_k127_2391642_47 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000000000000000000007856 236.0
TLS1_k127_2391642_48 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000000000008657 214.0
TLS1_k127_2391642_49 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000001031 216.0
TLS1_k127_2391642_5 amidohydrolase K12941,K21613 - - 2.752e-217 686.0
TLS1_k127_2391642_50 PFAM CoA-binding domain protein K06929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000168 220.0
TLS1_k127_2391642_51 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000009661 208.0
TLS1_k127_2391642_52 AMP binding K09118,K13693 - 2.4.1.266 0.00000000000000000000000000000000000000000000000000000002426 209.0
TLS1_k127_2391642_53 Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source K01483 - 4.3.2.3 0.00000000000000000000000000000000000000000000000000004354 193.0
TLS1_k127_2391642_54 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000000007319 192.0
TLS1_k127_2391642_55 OHCU decarboxylase K13485 - 4.1.1.97 0.000000000000000000000000000000000000000000000000001679 187.0
TLS1_k127_2391642_56 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07032 - - 0.0000000000000000000000000000000000000000000000006238 179.0
TLS1_k127_2391642_57 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.0000000000000000000000000000000000000000000004123 169.0
TLS1_k127_2391642_58 Cobalamin-5-phosphate synthase K02233 - 2.7.8.26 0.00000000000000000000000000000000000000000008375 170.0
TLS1_k127_2391642_59 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000001084 161.0
TLS1_k127_2391642_6 Beta-eliminating lyase K01738,K01740 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 4.97e-217 680.0
TLS1_k127_2391642_60 gag-polyprotein putative aspartyl protease K06985 - - 0.0000000000000000000000000000000000000002491 160.0
TLS1_k127_2391642_61 Transcription elongation factor, GreA/GreB, C-term - - - 0.000000000000000000000000000000000000003536 151.0
TLS1_k127_2391642_62 protein conserved in bacteria - - - 0.000000000000000000000000000000000009912 142.0
TLS1_k127_2391642_63 von Willebrand factor, type A - - - 0.000000000000000000000000000002769 124.0
TLS1_k127_2391642_64 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000000003737 120.0
TLS1_k127_2391642_65 HupE / UreJ protein K03192 - - 0.00000000000000000000000000002248 124.0
TLS1_k127_2391642_66 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000049 110.0
TLS1_k127_2391642_68 Aspartyl protease K06985 - - 0.000000000000000000000005183 108.0
TLS1_k127_2391642_69 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000000000000000000002746 110.0
TLS1_k127_2391642_7 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 6.879e-208 659.0
TLS1_k127_2391642_70 Glyoxalase-like domain - - - 0.0000000000000000000003414 106.0
TLS1_k127_2391642_71 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase - - - 0.00000000000000001612 86.0
TLS1_k127_2391642_72 Protein of unknown function (DUF1289) K06938 - - 0.000000000000001657 79.0
TLS1_k127_2391642_73 secreted Zn-dependent protease - - - 0.00001816 55.0
TLS1_k127_2391642_8 CO dehydrogenase flavoprotein C-terminal domain K13481 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 597.0
TLS1_k127_2391642_9 Peptidase dimerisation domain K01436 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 569.0
TLS1_k127_2516274_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1652.0
TLS1_k127_2516274_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1146.0
TLS1_k127_2516274_10 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 428.0
TLS1_k127_2516274_11 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 433.0
TLS1_k127_2516274_12 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 401.0
TLS1_k127_2516274_13 PFAM Patatin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 344.0
TLS1_k127_2516274_14 PFAM Benzoate membrane transport protein K05782 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 329.0
TLS1_k127_2516274_15 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 322.0
TLS1_k127_2516274_16 Cytochrome C1 family K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 288.0
TLS1_k127_2516274_17 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 286.0
TLS1_k127_2516274_18 ABC-type molybdate transport system, permease component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001958 279.0
TLS1_k127_2516274_19 Metallo-beta-lactamase superfamily - GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007514 274.0
TLS1_k127_2516274_2 Elongation factor G, domain IV K02355 - - 5.458e-272 855.0
TLS1_k127_2516274_20 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007967 273.0
TLS1_k127_2516274_21 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001346 259.0
TLS1_k127_2516274_22 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K22270 - 1.14.13.24 0.000000000000000000000000000000000000000000000000000000000000000000002138 250.0
TLS1_k127_2516274_23 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000446 231.0
TLS1_k127_2516274_24 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000003545 230.0
TLS1_k127_2516274_25 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001441 238.0
TLS1_k127_2516274_26 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000002264 224.0
TLS1_k127_2516274_27 Transcriptional - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000001817 217.0
TLS1_k127_2516274_28 Bacterial extracellular solute-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.00000000000000000000000000000000000000000000000000000000001152 216.0
TLS1_k127_2516274_29 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000002221 181.0
TLS1_k127_2516274_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00410,K00412 - - 1.734e-215 674.0
TLS1_k127_2516274_30 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000003789 183.0
TLS1_k127_2516274_31 Glutathione S-Transferase K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000000002072 177.0
TLS1_k127_2516274_32 Ribonuclease T2 family K01166,K01169 - 3.1.27.1,3.1.27.6 0.0000000000000000000000000000000000000000001762 171.0
TLS1_k127_2516274_33 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000007075 154.0
TLS1_k127_2516274_34 Fatty acid hydroxylase - - - 0.0000000000000000000000000000000000000353 153.0
TLS1_k127_2516274_35 Protein of unknown function (DUF992) - - - 0.000000000000000000000000000000001266 135.0
TLS1_k127_2516274_36 Cold shock protein domain K03704 - - 0.00000000000000000000000000001539 123.0
TLS1_k127_2516274_37 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000003498 124.0
TLS1_k127_2516274_38 Cold shock protein domain K03704 - - 0.000000000000000000000000005796 112.0
TLS1_k127_2516274_39 Cache domain - - - 0.000000000000003484 81.0
TLS1_k127_2516274_4 DegT/DnrJ/EryC1/StrS aminotransferase family K00812 - 2.6.1.1 3.818e-208 652.0
TLS1_k127_2516274_40 Outer membrane autotransporter K12681,K12683 GO:0005575,GO:0005576,GO:0005623,GO:0009986,GO:0044464 - 0.00000000003844 70.0
TLS1_k127_2516274_41 Protein of unknown function (DUF2846) - - - 0.00000003048 61.0
TLS1_k127_2516274_42 secreted Zn-dependent protease - - - 0.000001546 59.0
TLS1_k127_2516274_44 PAN domain - - - 0.000156 51.0
TLS1_k127_2516274_45 - - - - 0.0005617 48.0
TLS1_k127_2516274_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 2.813e-194 612.0
TLS1_k127_2516274_6 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 582.0
TLS1_k127_2516274_7 Domain of unknown function (DUF4915) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 484.0
TLS1_k127_2516274_8 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 462.0
TLS1_k127_2516274_9 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 442.0
TLS1_k127_2566127_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 4.061e-211 664.0
TLS1_k127_2566127_1 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 541.0
TLS1_k127_2566127_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 398.0
TLS1_k127_2614735_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017076,GO:0019866,GO:0030554,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046686,GO:0046872,GO:0046914,GO:0048046,GO:0050896,GO:0050897,GO:0055114,GO:0070469,GO:0097159,GO:0097367,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 7.751e-222 695.0
TLS1_k127_2614735_1 COG0665 Glycine D-amino acid oxidases (deaminating) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 505.0
TLS1_k127_2614735_2 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 430.0
TLS1_k127_2614735_3 Phage integrase, N-terminal SAM-like domain K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 330.0
TLS1_k127_2681193_0 Acetolactate synthase K01652 - 2.2.1.6 4.407e-321 989.0
TLS1_k127_2681193_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 7.657e-216 677.0
TLS1_k127_2681193_10 NMT1-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 348.0
TLS1_k127_2681193_11 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006707 308.0
TLS1_k127_2681193_12 prohibitin homologues K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 318.0
TLS1_k127_2681193_13 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007628 299.0
TLS1_k127_2681193_14 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 293.0
TLS1_k127_2681193_15 Acetolactate synthase small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000005636 259.0
TLS1_k127_2681193_16 AsmA-like C-terminal region K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000000008083 265.0
TLS1_k127_2681193_17 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000000002043 194.0
TLS1_k127_2681193_18 Protein conserved in bacteria K09985 - - 0.00000000000000000000000000000000000000000000008811 174.0
TLS1_k127_2681193_19 Ribbon-helix-helix domain - - - 0.0000000000000001443 82.0
TLS1_k127_2681193_2 K+ potassium transporter K03549 - - 5.439e-209 667.0
TLS1_k127_2681193_20 - - - - 0.00000005072 57.0
TLS1_k127_2681193_21 FecR protein - - - 0.00003226 57.0
TLS1_k127_2681193_3 FAD linked oxidases, C-terminal domain K00004,K00102 GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.1.1.303,1.1.1.4,1.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005833 609.0
TLS1_k127_2681193_4 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 575.0
TLS1_k127_2681193_5 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006874 539.0
TLS1_k127_2681193_6 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 429.0
TLS1_k127_2681193_7 PHP family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 364.0
TLS1_k127_2681193_8 Bacterial membrane protein N terminal K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 358.0
TLS1_k127_2681193_9 murein endopeptidase K07261 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 351.0
TLS1_k127_2715260_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1205.0
TLS1_k127_2715260_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1043.0
TLS1_k127_2715260_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 566.0
TLS1_k127_2715260_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007092 546.0
TLS1_k127_2715260_12 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009504 496.0
TLS1_k127_2715260_13 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 467.0
TLS1_k127_2715260_14 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 403.0
TLS1_k127_2715260_15 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 339.0
TLS1_k127_2715260_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 325.0
TLS1_k127_2715260_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008877 321.0
TLS1_k127_2715260_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 319.0
TLS1_k127_2715260_19 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 311.0
TLS1_k127_2715260_2 NADH-ubiquinone oxidoreductase subunit G, C-terminal K00336 - 1.6.5.3 2.629e-313 973.0
TLS1_k127_2715260_20 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003769 275.0
TLS1_k127_2715260_21 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000112 236.0
TLS1_k127_2715260_22 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.0000000000000000000000000000000000000000000000000000000005531 203.0
TLS1_k127_2715260_23 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000612 203.0
TLS1_k127_2715260_24 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000006675 208.0
TLS1_k127_2715260_25 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000008429 192.0
TLS1_k127_2715260_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000004732 170.0
TLS1_k127_2715260_27 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000002731 179.0
TLS1_k127_2715260_28 glutamine amidotransferase K01951 - 6.3.5.2 0.000000000000000000000000000000000000000001215 169.0
TLS1_k127_2715260_29 Flp pilus assembly protein TadG - - - 0.0000000000000000000000000000000000000001181 166.0
TLS1_k127_2715260_3 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 5.248e-293 912.0
TLS1_k127_2715260_30 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000001712 113.0
TLS1_k127_2715260_31 - - - - 0.0000000000000000000000004548 113.0
TLS1_k127_2715260_32 EamA-like transporter family - - - 0.0000000000000000000001919 99.0
TLS1_k127_2715260_33 - - - - 0.0000006529 59.0
TLS1_k127_2715260_34 regulation of single-species biofilm formation K13573 - - 0.0000009148 59.0
TLS1_k127_2715260_35 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00002121 55.0
TLS1_k127_2715260_37 recombinase activity - - - 0.0005464 46.0
TLS1_k127_2715260_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 6.756e-252 780.0
TLS1_k127_2715260_5 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 1.603e-245 765.0
TLS1_k127_2715260_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 1.837e-240 745.0
TLS1_k127_2715260_7 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 9.614e-236 733.0
TLS1_k127_2715260_8 NADH-quinone oxidoreductase chain K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 1.352e-227 718.0
TLS1_k127_2715260_9 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 605.0
TLS1_k127_2768572_0 Proton-conducting membrane transporter - - - 1.815e-259 823.0
TLS1_k127_2768572_1 Proton-conducting membrane transporter K12141 - - 8.664e-222 707.0
TLS1_k127_2768572_2 NADH-ubiquinone oxidoreductase chain 49kDa - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007575 533.0
TLS1_k127_2768572_3 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 453.0
TLS1_k127_2768572_4 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 299.0
TLS1_k127_2768572_5 transcriptional regulator - - - 0.00000000000000000000000000000001541 128.0
TLS1_k127_2783096_0 His Kinase A (phosphoacceptor) domain K13587 - 2.7.13.3 1.336e-239 766.0
TLS1_k127_2783096_1 YcjX-like family, DUF463 K06918 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 543.0
TLS1_k127_2783096_10 PilZ domain - - - 0.0000000000132 70.0
TLS1_k127_2783096_11 Protein of unknown function (DUF3494) - - - 0.00006674 53.0
TLS1_k127_2783096_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00651 - 2.3.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009481 487.0
TLS1_k127_2783096_3 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 460.0
TLS1_k127_2783096_4 (ABC) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 412.0
TLS1_k127_2783096_5 Glycine D-amino acid oxidases (deaminating) K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007476 375.0
TLS1_k127_2783096_6 UPF0283 membrane protein K08990 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000003098 254.0
TLS1_k127_2783096_7 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000000000000005578 229.0
TLS1_k127_2783096_8 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000000000000000004094 123.0
TLS1_k127_2783096_9 Flagellar biosynthesis protein, FliO - - - 0.00000000000006756 78.0
TLS1_k127_282543_0 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K10441 - 3.6.3.17 8.144e-217 684.0
TLS1_k127_282543_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 5.914e-201 635.0
TLS1_k127_282543_10 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007436 495.0
TLS1_k127_282543_11 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 479.0
TLS1_k127_282543_12 transport system, permease component K05778 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 491.0
TLS1_k127_282543_13 Bacterial extracellular solute-binding protein K02055,K05777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 475.0
TLS1_k127_282543_14 Carboxyltransferase domain, subdomain C and D K01941 - 6.3.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004991 467.0
TLS1_k127_282543_15 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 460.0
TLS1_k127_282543_16 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 460.0
TLS1_k127_282543_17 cobalamin biosynthesis protein CobW K02234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009344 449.0
TLS1_k127_282543_18 Branched-chain amino acid transport system / permease component K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 433.0
TLS1_k127_282543_19 ABC transporter K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 441.0
TLS1_k127_282543_2 ribose ABC transporter K10439 - - 1.445e-195 615.0
TLS1_k127_282543_20 Branched-chain amino acid transport system / permease component K02057,K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 428.0
TLS1_k127_282543_21 Branched-chain amino acid transport system / permease component K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 427.0
TLS1_k127_282543_22 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 412.0
TLS1_k127_282543_23 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 408.0
TLS1_k127_282543_24 LamB/YcsF family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 405.0
TLS1_k127_282543_25 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 397.0
TLS1_k127_282543_26 ABC-type spermidine putrescine transport system, permease component II K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 375.0
TLS1_k127_282543_27 Alpha beta hydrolase K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 357.0
TLS1_k127_282543_28 ABC transporter K05779 - - 0.00000000000000000000000000000000000000000000000000000000000000000001138 245.0
TLS1_k127_282543_29 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000002567 231.0
TLS1_k127_282543_3 Creatinase/Prolidase N-terminal domain K15783 - 3.5.4.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 612.0
TLS1_k127_282543_30 Probable cobalt transporter subunit (CbtA) - - - 0.00000000000000000000000000000000000000000000000000000000000008773 220.0
TLS1_k127_282543_31 BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000000000001147 200.0
TLS1_k127_282543_32 Cytochrome c mono- and diheme variants - - - 0.00000000000000000000000000000000000000000000000000002034 192.0
TLS1_k127_282543_33 Domain of unknown function (DUF1989) K09967 - - 0.0000000000000000000000000000000000000009756 156.0
TLS1_k127_282543_34 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA - - - 0.00000000000000000000000000000000133 130.0
TLS1_k127_282543_35 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000006617 123.0
TLS1_k127_282543_36 Response regulator receiver - - - 0.0000000000000000004899 93.0
TLS1_k127_282543_37 Cobalt transporter subunit CbtB - - - 0.000000000009369 70.0
TLS1_k127_282543_39 Helix-turn-helix - - - 0.00008955 49.0
TLS1_k127_282543_4 binding protein component of ABC transporter K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 566.0
TLS1_k127_282543_5 Monosaccharide ABC transporter ATP-binding protein, CUT2 family K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 577.0
TLS1_k127_282543_6 PFAM Prokaryotic protein of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 552.0
TLS1_k127_282543_7 Allophanate hydrolase subunit 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 528.0
TLS1_k127_282543_8 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 519.0
TLS1_k127_282543_9 COG1879 ABC-type sugar transport system, periplasmic component K11930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009512 502.0
TLS1_k127_2836530_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 0.0 1304.0
TLS1_k127_2836530_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1300.0
TLS1_k127_2836530_10 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 453.0
TLS1_k127_2836530_11 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 422.0
TLS1_k127_2836530_12 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 323.0
TLS1_k127_2836530_13 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000769 323.0
TLS1_k127_2836530_14 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 312.0
TLS1_k127_2836530_15 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008485 305.0
TLS1_k127_2836530_16 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001247 265.0
TLS1_k127_2836530_17 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002967 263.0
TLS1_k127_2836530_18 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000004543 242.0
TLS1_k127_2836530_19 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000000000000000000000000000000000008823 235.0
TLS1_k127_2836530_2 helicase superfamily c-terminal domain K17675 - 3.6.4.13 3.791e-307 972.0
TLS1_k127_2836530_20 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000001322 229.0
TLS1_k127_2836530_21 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000000001408 218.0
TLS1_k127_2836530_22 PFAM heat shock protein DnaJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000005353 223.0
TLS1_k127_2836530_23 NUDIX domain K03574 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000001161 217.0
TLS1_k127_2836530_24 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000001034 224.0
TLS1_k127_2836530_25 peptidyl-prolyl isomerase K01802,K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000003815 213.0
TLS1_k127_2836530_26 Esterase-like activity of phytase - - - 0.000000000000000000000000000000000000000000000000007181 194.0
TLS1_k127_2836530_27 Protein of unknown function (DUF1178) - - - 0.00000000000000000000000000000000000000006967 155.0
TLS1_k127_2836530_28 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000001719 132.0
TLS1_k127_2836530_29 - - - - 0.00000000000000000000000000001852 119.0
TLS1_k127_2836530_3 PEP-utilising enzyme, N-terminal K08484 - 2.7.3.9 1.757e-272 857.0
TLS1_k127_2836530_30 Domain of unknown function (DUF4167) - - - 0.0000000000000000000000000001846 124.0
TLS1_k127_2836530_31 BolA-like protein K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.000000000000000000000000001434 114.0
TLS1_k127_2836530_32 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.00000000000000000005936 93.0
TLS1_k127_2836530_33 protein conserved in bacteria K15539 - - 0.000000000000000111 92.0
TLS1_k127_2836530_34 Protein of unknown function (DUF3108) - - - 0.0000000000000006088 89.0
TLS1_k127_2836530_35 - - - - 0.00000000000001888 76.0
TLS1_k127_2836530_36 - - - - 0.00000000001324 64.0
TLS1_k127_2836530_37 - - - - 0.00000000001335 64.0
TLS1_k127_2836530_38 - - - - 0.0001124 46.0
TLS1_k127_2836530_4 Cobalamin biosynthesis protein CobT VWA domain K09883 - 6.6.1.2 2.301e-250 786.0
TLS1_k127_2836530_5 ACT domain K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 588.0
TLS1_k127_2836530_6 cobaltochelatase, CobS subunit K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 550.0
TLS1_k127_2836530_7 Domain of unknown function DUF21 K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 535.0
TLS1_k127_2836530_8 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 459.0
TLS1_k127_2836530_9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 449.0
TLS1_k127_2884598_0 CoA binding domain - - - 0.0 1220.0
TLS1_k127_2884598_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0 1045.0
TLS1_k127_2884598_10 Belongs to the 'phage' integrase family - - - 0.0000368 49.0
TLS1_k127_2884598_11 Transcriptional regulator - - - 0.00007035 49.0
TLS1_k127_2884598_2 Tripartite tricarboxylate transporter TctA family K07793 - - 2.585e-258 804.0
TLS1_k127_2884598_3 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 4.629e-246 762.0
TLS1_k127_2884598_4 Tripartite tricarboxylate transporter family receptor K07795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009775 488.0
TLS1_k127_2884598_5 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 372.0
TLS1_k127_2884598_6 Acetyltransferase (GNAT) domain K00663 - 2.3.1.82 0.0000000000000000000000000000000000000000000000000000000000000009032 223.0
TLS1_k127_2884598_7 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000001853 182.0
TLS1_k127_2884598_8 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000000000000008664 162.0
TLS1_k127_2884598_9 - - - - 0.000000651 59.0
TLS1_k127_2921694_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 3102.0
TLS1_k127_2921694_1 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1382.0
TLS1_k127_2921694_10 4Fe-4S dicluster domain K00124,K21308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 402.0
TLS1_k127_2921694_11 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 403.0
TLS1_k127_2921694_12 cobalamin binding protein K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 396.0
TLS1_k127_2921694_13 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 391.0
TLS1_k127_2921694_14 NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 349.0
TLS1_k127_2921694_15 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 327.0
TLS1_k127_2921694_16 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 321.0
TLS1_k127_2921694_17 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 330.0
TLS1_k127_2921694_18 DMSO reductase anchor subunit (DmsC) K21309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003842 269.0
TLS1_k127_2921694_19 LysR substrate binding domain K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001967 258.0
TLS1_k127_2921694_2 Domain of unknown function (DUF4445) - - - 2.392e-309 959.0
TLS1_k127_2921694_20 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003093 253.0
TLS1_k127_2921694_21 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000003712 233.0
TLS1_k127_2921694_22 COG1145 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000001941 225.0
TLS1_k127_2921694_23 homocysteine K00547 - 2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000001708 227.0
TLS1_k127_2921694_24 Male sterility protein K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000741 212.0
TLS1_k127_2921694_25 Spore Coat Protein U domain - - - 0.000000000000000000000000000000000000000000000000000004288 201.0
TLS1_k127_2921694_26 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000007864 190.0
TLS1_k127_2921694_27 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000005151 185.0
TLS1_k127_2921694_28 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000006661 162.0
TLS1_k127_2921694_29 Virulence factor - - - 0.0000000000000000000000000000000000296 137.0
TLS1_k127_2921694_3 DNA ligase K01971 - 6.5.1.1 1.122e-232 747.0
TLS1_k127_2921694_30 EamA-like transporter family K15270 - - 0.0000000000000000000000000000009402 128.0
TLS1_k127_2921694_31 EamA-like transporter family K15270 - - 0.00000000000000000000001716 111.0
TLS1_k127_2921694_32 Transglycosylase SLT domain - - - 0.0000000000000000001564 95.0
TLS1_k127_2921694_33 PRC-barrel domain - - - 0.00000000000000001177 93.0
TLS1_k127_2921694_34 Rhamnan synthesis protein F - - - 0.00000000000000001448 94.0
TLS1_k127_2921694_35 Protein of unknwon function (DUF3008) - - - 0.000000000000001861 77.0
TLS1_k127_2921694_36 - - - - 0.000000000005268 69.0
TLS1_k127_2921694_37 Plasmid stabilization - - - 0.0000002139 57.0
TLS1_k127_2921694_4 Trimethylamine methyltransferase (MTTB) - - - 5.608e-218 687.0
TLS1_k127_2921694_5 Methyltransferase K14083 - 2.1.1.250 2.176e-210 666.0
TLS1_k127_2921694_6 Methyltransferase K14083 - 2.1.1.250 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 610.0
TLS1_k127_2921694_7 helix_turn_helix gluconate operon transcriptional repressor K00375 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 518.0
TLS1_k127_2921694_8 COG1410 Methionine synthase I cobalamin-binding domain K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 449.0
TLS1_k127_2921694_9 Homocysteine S-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 430.0
TLS1_k127_3064897_0 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007596 357.0
TLS1_k127_3064897_1 PFAM regulatory protein LuxR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006101 301.0
TLS1_k127_3064897_2 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000008945 75.0
TLS1_k127_3064897_3 PQQ-like domain - - - 0.00000105 51.0
TLS1_k127_3100227_0 Belongs to the GcvT family K19191 GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 0.0 1281.0
TLS1_k127_3100227_1 Belongs to the GcvT family K19191 - 1.5.3.19 0.0 1279.0
TLS1_k127_3100227_10 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 409.0
TLS1_k127_3100227_11 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 385.0
TLS1_k127_3100227_12 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 358.0
TLS1_k127_3100227_13 Choline/ethanolamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 348.0
TLS1_k127_3100227_14 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 312.0
TLS1_k127_3100227_15 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 292.0
TLS1_k127_3100227_16 His Kinase A (phosphoacceptor) domain K07716 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000998 249.0
TLS1_k127_3100227_17 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008032 244.0
TLS1_k127_3100227_18 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009164,GO:0009972,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.5.4.5 0.00000000000000000000000000000000000000000000000000002727 200.0
TLS1_k127_3100227_19 Zincin-like metallopeptidase K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000001365 189.0
TLS1_k127_3100227_2 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 6.274e-316 975.0
TLS1_k127_3100227_20 Belongs to the pyridoxine kinase family K00868 - 2.7.1.35 0.000000000000000000000000000000000000000000000002232 183.0
TLS1_k127_3100227_21 Succinate dehydrogenase Fumarate reductase K00241 - - 0.00000000000000000000000000000000000000000000002105 174.0
TLS1_k127_3100227_22 Low affinity iron permease - - - 0.00000000000000000000000000000000307 133.0
TLS1_k127_3100227_23 succinate dehydrogenase K00242 - - 0.00000000000000000000000000001359 121.0
TLS1_k127_3100227_24 response regulator - - - 0.00000000000000000000000009205 111.0
TLS1_k127_3100227_25 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000003769 83.0
TLS1_k127_3100227_26 Phosphate transporter family K03306 - - 0.0000000000000005472 81.0
TLS1_k127_3100227_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.526e-259 805.0
TLS1_k127_3100227_4 Domain of unknown function DUF87 K06915 - - 1.029e-198 639.0
TLS1_k127_3100227_5 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 558.0
TLS1_k127_3100227_6 Isocitrate/isopropylmalate dehydrogenase K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004657 555.0
TLS1_k127_3100227_7 MaoC like domain K14449 GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 464.0
TLS1_k127_3100227_8 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007793 449.0
TLS1_k127_3100227_9 Choline ethanolamine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 431.0
TLS1_k127_311797_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 5.382e-198 632.0
TLS1_k127_311797_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 569.0
TLS1_k127_311797_10 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000005244 232.0
TLS1_k127_311797_11 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000004317 212.0
TLS1_k127_311797_12 - - - - 0.000000000000000000000000000000000000000000000000000000000006613 213.0
TLS1_k127_311797_13 PFAM NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000008545 210.0
TLS1_k127_311797_14 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000000001193 208.0
TLS1_k127_311797_15 FecR protein - - - 0.0000000000000000000000000000000000000000000000000000001297 203.0
TLS1_k127_311797_16 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000005273 187.0
TLS1_k127_311797_17 VIT family - - - 0.000000000000000000000000000000000000000000000000006697 186.0
TLS1_k127_311797_18 - - - - 0.000000000000000000000000000000000000000000007755 166.0
TLS1_k127_311797_19 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000033 153.0
TLS1_k127_311797_2 ABC transporter K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 489.0
TLS1_k127_311797_20 - - - - 0.00000000000000000000000000000000000007818 154.0
TLS1_k127_311797_21 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000009215 148.0
TLS1_k127_311797_22 - - - - 0.00000000000000000000000000000006841 128.0
TLS1_k127_311797_23 PFAM Porin K16079 - - 0.0000000000000000000000001629 114.0
TLS1_k127_311797_24 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000001225 97.0
TLS1_k127_311797_25 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000000001183 97.0
TLS1_k127_311797_26 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000000005415 61.0
TLS1_k127_311797_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 479.0
TLS1_k127_311797_4 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 461.0
TLS1_k127_311797_5 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 361.0
TLS1_k127_311797_6 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 341.0
TLS1_k127_311797_7 Ion transport 2 domain protein K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002625 317.0
TLS1_k127_311797_8 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001583 243.0
TLS1_k127_311797_9 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000003926 232.0
TLS1_k127_3119378_0 hmm pf01609 K07481 - - 1.541e-217 682.0
TLS1_k127_3146085_0 Belongs to the GcvT family K00605 - 2.1.2.10 0.0 1231.0
TLS1_k127_3146085_1 ABC transporter substrate-binding protein K02027 - - 2.733e-263 817.0
TLS1_k127_3146085_10 WHG domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 285.0
TLS1_k127_3146085_11 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001515 278.0
TLS1_k127_3146085_12 FCD K22104 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003136 267.0
TLS1_k127_3146085_13 PFAM Thiamin pyrophosphokinase catalytic K00949 - 2.7.6.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000007998 263.0
TLS1_k127_3146085_14 Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system K02062 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009296 259.0
TLS1_k127_3146085_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005482 246.0
TLS1_k127_3146085_16 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.0000000000000000000000000000000000000000000136 169.0
TLS1_k127_3146085_17 - - - - 0.00000000000000000000000000000000002571 142.0
TLS1_k127_3146085_18 Protein of unknown function (DUF2852) - - - 0.000000000000000000000000000000002604 134.0
TLS1_k127_3146085_19 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000578 125.0
TLS1_k127_3146085_2 Conserved region in glutamate synthase K22083 - 2.1.1.21 3.362e-259 802.0
TLS1_k127_3146085_20 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000001348 132.0
TLS1_k127_3146085_21 GYD domain - - - 0.00000000000000000000004336 103.0
TLS1_k127_3146085_22 ABC-type sugar transport system, permease component K02026,K17323 - - 0.00000008585 54.0
TLS1_k127_3146085_3 acyl-coa dehydrogenase - - - 1.004e-248 773.0
TLS1_k127_3146085_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007825 536.0
TLS1_k127_3146085_5 COG1175 ABC-type sugar transport systems permease components K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 479.0
TLS1_k127_3146085_6 thiamine ABC transporter K02064 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 453.0
TLS1_k127_3146085_7 lysyl-tRNA synthetase K04568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 443.0
TLS1_k127_3146085_8 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 394.0
TLS1_k127_3146085_9 ABC-type Fe3 transport system, permease component K02063 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 409.0
TLS1_k127_3150697_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 490.0
TLS1_k127_3150697_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 331.0
TLS1_k127_3150697_2 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000000000000000000000000000000000000000001529 207.0
TLS1_k127_3253958_0 COG2801 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000659 437.0
TLS1_k127_3253958_1 Transposase - - - 0.00000000000000000000000003413 110.0
TLS1_k127_3253958_2 Molybdenum cofactor synthesis K03750 - 2.10.1.1 0.00000000000001563 77.0
TLS1_k127_3274748_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - - 0.0 1282.0
TLS1_k127_3274748_1 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05561 - - 6.749e-197 626.0
TLS1_k127_3274748_2 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005329 253.0
TLS1_k127_3274748_3 Multisubunit Na H antiporter, MnhE subunit K05562 - - 0.00000000000000000000000000000000000000000000000000000000000000000005886 234.0
TLS1_k127_3274748_4 FAD binding domain K00480 - 1.14.13.1 0.00000000000000000000000000000000000000000000000000000000003392 213.0
TLS1_k127_3274748_5 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000000000008542 167.0
TLS1_k127_3274748_6 Multisubunit Na H antiporter, MnhC subunit K05560 - - 0.00000000000000000000000000000000000000007289 157.0
TLS1_k127_3274748_7 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05563 - - 0.0004185 44.0
TLS1_k127_328485_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 502.0
TLS1_k127_328485_1 DNA-directed DNA polymerase K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 379.0
TLS1_k127_3322473_0 2-oxoglutarate dehydrogenase C-terminal K00164 - 1.2.4.2 0.0 1437.0
TLS1_k127_3322473_1 TIGRFAM methylmalonate-semialdehyde dehydrogenase K00140 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896 1.2.1.18,1.2.1.27 4.069e-267 828.0
TLS1_k127_3322473_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 543.0
TLS1_k127_3322473_3 lactate/malate dehydrogenase, NAD binding domain K00024 GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 505.0
TLS1_k127_3322473_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 471.0
TLS1_k127_3322473_5 AFG1-like ATPase K06916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009453 311.0
TLS1_k127_3322473_6 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000008635 184.0
TLS1_k127_3322473_7 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000007894 167.0
TLS1_k127_3322473_8 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000006323 130.0
TLS1_k127_3352166_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1110.0
TLS1_k127_3352166_1 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006275 441.0
TLS1_k127_3352166_10 Belongs to the BolA IbaG family - - - 0.0000000000000000000000000000000007746 132.0
TLS1_k127_3352166_11 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000002501 124.0
TLS1_k127_3352166_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 336.0
TLS1_k127_3352166_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 331.0
TLS1_k127_3352166_4 CobB/CobQ-like glutamine amidotransferase domain K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 317.0
TLS1_k127_3352166_5 Protein of unknown function DUF262 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 309.0
TLS1_k127_3352166_6 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000002667 220.0
TLS1_k127_3352166_7 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000000009743 179.0
TLS1_k127_3352166_8 Domain of unknown function (DUF1476) - - - 0.00000000000000000000000000000000000000000005154 163.0
TLS1_k127_3352166_9 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000003566 158.0
TLS1_k127_3356209_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088,K00364 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205,1.7.1.7 3.443e-213 677.0
TLS1_k127_3356209_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 467.0
TLS1_k127_3356209_2 MAPEG family - - - 0.000000000000000000000000000003502 124.0
TLS1_k127_3356209_3 phosphate transporter - - - 0.0000000000000000000004423 99.0
TLS1_k127_3356209_4 cheY-homologous receiver domain - - - 0.000000000001478 73.0
TLS1_k127_3389944_0 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.0 1223.0
TLS1_k127_3389944_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1043.0
TLS1_k127_3389944_10 COG0714 MoxR-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009547 451.0
TLS1_k127_3389944_11 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 441.0
TLS1_k127_3389944_12 beta-keto acid cleavage enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 439.0
TLS1_k127_3389944_13 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 437.0
TLS1_k127_3389944_14 Aminotransferase class-III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 440.0
TLS1_k127_3389944_15 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009491 419.0
TLS1_k127_3389944_16 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 421.0
TLS1_k127_3389944_17 Belongs to the enoyl-CoA hydratase isomerase family K08299 - 4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006264 383.0
TLS1_k127_3389944_18 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 400.0
TLS1_k127_3389944_19 Serine acetyltransferase, N-terminal K00640 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009314,GO:0009333,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 348.0
TLS1_k127_3389944_2 Oxidoreductase molybdopterin binding domain - - - 1.461e-226 709.0
TLS1_k127_3389944_20 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K17735 - 1.1.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 349.0
TLS1_k127_3389944_21 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 347.0
TLS1_k127_3389944_22 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 330.0
TLS1_k127_3389944_23 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 329.0
TLS1_k127_3389944_24 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 321.0
TLS1_k127_3389944_25 isochorismatase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 310.0
TLS1_k127_3389944_26 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 316.0
TLS1_k127_3389944_27 Belongs to the SfsA family K06206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 300.0
TLS1_k127_3389944_28 C-C_Bond_Lyase of the TIM-Barrel fold K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 296.0
TLS1_k127_3389944_29 GTP cyclohydrolase K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004972 272.0
TLS1_k127_3389944_3 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 1.314e-206 653.0
TLS1_k127_3389944_30 transcriptional regulator K17736 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001177 273.0
TLS1_k127_3389944_31 Phosphoribosyl transferase domain K00769 - 2.4.2.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000001897 261.0
TLS1_k127_3389944_32 Amino acid synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001038 259.0
TLS1_k127_3389944_33 Alpha beta hydrolase K00433 - 1.11.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000001919 252.0
TLS1_k127_3389944_34 UPF0314 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008628 247.0
TLS1_k127_3389944_35 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002061 243.0
TLS1_k127_3389944_36 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000000000000000000009335 237.0
TLS1_k127_3389944_37 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000006752 234.0
TLS1_k127_3389944_38 COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000004966 232.0
TLS1_k127_3389944_39 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001706 228.0
TLS1_k127_3389944_4 acyl-CoA dehydrogenase K00249 - 1.3.8.7 7.412e-202 633.0
TLS1_k127_3389944_40 NifU-like N terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008235 221.0
TLS1_k127_3389944_41 COG0778 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000002712 214.0
TLS1_k127_3389944_42 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000003893 223.0
TLS1_k127_3389944_43 Subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000183 203.0
TLS1_k127_3389944_44 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000008931 196.0
TLS1_k127_3389944_45 GYD domain - - - 0.00000000000000000000000000000000000000000000000002423 183.0
TLS1_k127_3389944_46 Cupin domain - - - 0.00000000000000000000000000000000000000000000000008989 181.0
TLS1_k127_3389944_47 Rhomboid family - - - 0.000000000000000000000000000000000000000000000008695 186.0
TLS1_k127_3389944_48 Phosphoribosyl-AMP cyclohydrolase K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000001158 170.0
TLS1_k127_3389944_49 periplasmic protein - - - 0.000000000000000000000000000000000000000000000554 177.0
TLS1_k127_3389944_5 FMN-dependent dehydrogenase K00101 - 1.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 606.0
TLS1_k127_3389944_50 XdhC and CoxI family - - - 0.0000000000000000000000000000000000000000001759 160.0
TLS1_k127_3389944_51 Domain of unknown function (DUF4864) - - - 0.0000000000000000000000000000000000003902 145.0
TLS1_k127_3389944_52 PFAM type IV pilus assembly PilZ - - - 0.0000000000000000000000000000000003032 139.0
TLS1_k127_3389944_53 Zinc-finger domain - - - 0.0000000000000000000000000000000698 127.0
TLS1_k127_3389944_54 Haemolytic K08998 - - 0.00000000000000000000000008996 110.0
TLS1_k127_3389944_55 oxidoreductase activity - - - 0.000000000000000000000000116 118.0
TLS1_k127_3389944_56 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000004065 119.0
TLS1_k127_3389944_57 Protein of unknown function (DUF3126) - - - 0.000000000000000000000005181 102.0
TLS1_k127_3389944_58 PAS domain - - - 0.000000000000000000005295 101.0
TLS1_k127_3389944_59 Belongs to the 'phage' integrase family - - - 0.00000000000000002147 85.0
TLS1_k127_3389944_6 COG1042 Acyl-CoA synthetase (NDP forming) K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 619.0
TLS1_k127_3389944_60 Repressor involved in choline regulation of the bet genes K02167 - - 0.0000000000003615 72.0
TLS1_k127_3389944_61 Outer membrane protein beta-barrel domain - - - 0.0000000000006657 78.0
TLS1_k127_3389944_62 Response regulator receiver domain K03413 - - 0.000000000007541 71.0
TLS1_k127_3389944_63 Acetyltransferase (GNAT) domain - - - 0.00000000002748 72.0
TLS1_k127_3389944_64 FR47-like protein - - - 0.0000005238 59.0
TLS1_k127_3389944_65 - - - - 0.00004395 54.0
TLS1_k127_3389944_7 choline-sulfatase K01133 - 3.1.6.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 579.0
TLS1_k127_3389944_8 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 540.0
TLS1_k127_3389944_9 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 464.0
TLS1_k127_3413918_0 Type II/IV secretion system protein K02283 - - 1.002e-239 749.0
TLS1_k127_3413918_1 Extracellular solute-binding protein K02035,K13893 - - 1.851e-238 752.0
TLS1_k127_3413918_10 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 326.0
TLS1_k127_3413918_11 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 300.0
TLS1_k127_3413918_12 Type II secretion system (T2SS), protein F K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 304.0
TLS1_k127_3413918_13 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 287.0
TLS1_k127_3413918_14 PFAM NLP P60 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005343 281.0
TLS1_k127_3413918_15 Bacterial type II and III secretion system protein K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001302 249.0
TLS1_k127_3413918_16 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000003945 252.0
TLS1_k127_3413918_17 Cytochrome c, class I K08738 - - 0.0000000000000000000000000000000000000000000000000000000005803 211.0
TLS1_k127_3413918_18 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000825 194.0
TLS1_k127_3413918_19 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000002566 151.0
TLS1_k127_3413918_2 Belongs to the ABC transporter superfamily K02031,K02032,K13896 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 1.257e-236 745.0
TLS1_k127_3413918_20 Autotransporter beta-domain K19231 - - 0.0000000000000000000000000000000000000005166 170.0
TLS1_k127_3413918_21 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000003021 130.0
TLS1_k127_3413918_22 pilus assembly protein K02281 - - 0.00000000000000000000001995 109.0
TLS1_k127_3413918_23 Outer membrane autotransporter K12681,K12683 GO:0005575,GO:0005576,GO:0005623,GO:0009986,GO:0044464 - 0.000001854 58.0
TLS1_k127_3413918_3 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 2.968e-226 718.0
TLS1_k127_3413918_4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 595.0
TLS1_k127_3413918_5 Binding-protein-dependent transport system inner membrane component K13895 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 595.0
TLS1_k127_3413918_6 Cytosol aminopeptidase family, catalytic domain K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 534.0
TLS1_k127_3413918_7 Pilus assembly protein K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 450.0
TLS1_k127_3413918_8 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 390.0
TLS1_k127_3413918_9 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 367.0
TLS1_k127_354264_0 decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 594.0
TLS1_k127_354264_1 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 349.0
TLS1_k127_354264_10 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000009893 50.0
TLS1_k127_354264_2 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006981 291.0
TLS1_k127_354264_3 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000000001628 145.0
TLS1_k127_354264_4 Protein of unknown function (DUF3618) - - - 0.0000000000000000000000001448 119.0
TLS1_k127_354264_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000005752 87.0
TLS1_k127_354264_7 - - - - 0.000000000000004534 79.0
TLS1_k127_354264_8 Belongs to the 'phage' integrase family - - - 0.000000000001158 76.0
TLS1_k127_354264_9 Domain of unknown function (DUF4437) - - - 0.00000000004187 68.0
TLS1_k127_3630875_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1269.0
TLS1_k127_3630875_1 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 9.483e-229 713.0
TLS1_k127_3630875_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000001314 130.0
TLS1_k127_3630875_11 Usg-like family - - - 0.00000000000000000000000000003367 119.0
TLS1_k127_3630875_12 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000003291 119.0
TLS1_k127_3630875_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 595.0
TLS1_k127_3630875_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 455.0
TLS1_k127_3630875_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 333.0
TLS1_k127_3630875_5 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 312.0
TLS1_k127_3630875_6 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 294.0
TLS1_k127_3630875_7 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001154 262.0
TLS1_k127_3630875_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000006042 220.0
TLS1_k127_3630875_9 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000007361 193.0
TLS1_k127_3694043_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.21e-233 749.0
TLS1_k127_3694043_1 AAA domain (Cdc48 subfamily) K07712 - - 2.352e-208 659.0
TLS1_k127_3694043_10 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 361.0
TLS1_k127_3694043_11 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 353.0
TLS1_k127_3694043_12 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004627 341.0
TLS1_k127_3694043_13 Hydrolase, TatD family K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 335.0
TLS1_k127_3694043_14 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 339.0
TLS1_k127_3694043_15 MazG nucleotide pyrophosphohydrolase domain K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 308.0
TLS1_k127_3694043_16 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005198 289.0
TLS1_k127_3694043_17 dna polymerase iii K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000001425 267.0
TLS1_k127_3694043_18 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000004097 225.0
TLS1_k127_3694043_19 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000000005005 228.0
TLS1_k127_3694043_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K13598 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 5.829e-201 649.0
TLS1_k127_3694043_20 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000001518 209.0
TLS1_k127_3694043_21 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000000000009616 159.0
TLS1_k127_3694043_22 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0009399,GO:0071941,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000009283 142.0
TLS1_k127_3694043_23 Psort location Extracellular, score - - - 0.0000000000000000000000000000000001157 145.0
TLS1_k127_3694043_24 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00000698 50.0
TLS1_k127_3694043_3 PFAM response regulator receiver K13599 - - 3.981e-194 615.0
TLS1_k127_3694043_4 Required for the activity of the bacterial periplasmic transport system of putrescine K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 551.0
TLS1_k127_3694043_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 506.0
TLS1_k127_3694043_6 Peptidase dimerisation domain K01451 - 3.5.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 434.0
TLS1_k127_3694043_7 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007103 404.0
TLS1_k127_3694043_8 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008673 400.0
TLS1_k127_3694043_9 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000991 387.0
TLS1_k127_3704470_0 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 0.0 1128.0
TLS1_k127_3704470_1 Cobalamin synthesis G C-terminus K05934,K13541 - 2.1.1.131,3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 595.0
TLS1_k127_3704470_10 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 388.0
TLS1_k127_3704470_11 ABC transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004747 363.0
TLS1_k127_3704470_12 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 354.0
TLS1_k127_3704470_13 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005415 333.0
TLS1_k127_3704470_14 Belongs to the precorrin methyltransferase family K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 327.0
TLS1_k127_3704470_15 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 316.0
TLS1_k127_3704470_16 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 312.0
TLS1_k127_3704470_17 COG2243 Precorrin-2 methylase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000000000000000000000000007611 255.0
TLS1_k127_3704470_18 precorrin-6x reductase K05895 - 1.3.1.106,1.3.1.54 0.000000000000000000000000000000000000000000000000000000000000002801 225.0
TLS1_k127_3704470_19 Precorrin-8X methylmutase K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000005468 219.0
TLS1_k127_3704470_2 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 576.0
TLS1_k127_3704470_20 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000000000000000000000000000004188 179.0
TLS1_k127_3704470_21 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000000000000002027 166.0
TLS1_k127_3704470_22 metal-binding protein - - - 0.00000000000000000000000002499 112.0
TLS1_k127_3704470_23 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000001896 93.0
TLS1_k127_3704470_3 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 582.0
TLS1_k127_3704470_4 CbiX - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 475.0
TLS1_k127_3704470_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 473.0
TLS1_k127_3704470_6 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 466.0
TLS1_k127_3704470_7 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 433.0
TLS1_k127_3704470_8 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 437.0
TLS1_k127_3704470_9 Tetrapyrrole (Corrin/Porphyrin) Methylases K00595 - 2.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 397.0
TLS1_k127_3900305_0 Uncharacterised protein family (UPF0261) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009774 506.0
TLS1_k127_3900305_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000003099 177.0
TLS1_k127_3900305_2 Ankyrin repeat - - - 0.00000000000000000001535 94.0
TLS1_k127_3931193_0 Oligopeptide/dipeptide transporter, C-terminal region - - - 3.766e-250 782.0
TLS1_k127_3931193_1 Hydrolase CocE NonD family K06978 - - 2.793e-248 784.0
TLS1_k127_3931193_10 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 406.0
TLS1_k127_3931193_11 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 382.0
TLS1_k127_3931193_12 Binding-protein-dependent transport system inner membrane component K11074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 381.0
TLS1_k127_3931193_13 ABC-type spermidine putrescine transport system, permease component I K11075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 353.0
TLS1_k127_3931193_14 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008561 353.0
TLS1_k127_3931193_15 Required for the activity of the bacterial periplasmic transport system of putrescine K11073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 354.0
TLS1_k127_3931193_16 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 317.0
TLS1_k127_3931193_17 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006377 311.0
TLS1_k127_3931193_18 BetI-type transcriptional repressor, C-terminal K02167 - - 0.0000000000000000000000000000000000000000000000000000000000000000001698 236.0
TLS1_k127_3931193_19 Alpha beta hydrolase K01066 - - 0.000000000000000000000000000000000000000000000000000000003625 212.0
TLS1_k127_3931193_2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 570.0
TLS1_k127_3931193_20 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000002512 197.0
TLS1_k127_3931193_21 ApaG domain K06195 - - 0.0000000000000000000000000000000000000000000000001022 183.0
TLS1_k127_3931193_22 GcrA cell cycle regulator K13583 - - 0.000000000000000000000000000000000000000000000001707 181.0
TLS1_k127_3931193_23 Domain of unknown function (DUF892) - - - 0.00000000000000000000000000000000000000000000001047 176.0
TLS1_k127_3931193_24 NAD(P)H-dependent FMN reductase K19784 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006805,GO:0008150,GO:0008152,GO:0009410,GO:0009987,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0052873,GO:0055114,GO:0070887,GO:0071466,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000003104 172.0
TLS1_k127_3931193_25 Glycosyl transferase family 21 - - - 0.0000000000000000000002722 103.0
TLS1_k127_3931193_26 - - - - 0.0000000002149 65.0
TLS1_k127_3931193_27 Protein of unknown function (DUF3606) - - - 0.0002967 48.0
TLS1_k127_3931193_3 Acetylornithine aminotransferase K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004912 550.0
TLS1_k127_3931193_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 510.0
TLS1_k127_3931193_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 496.0
TLS1_k127_3931193_6 2-deoxycytidine 5-triphosphate deaminase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 489.0
TLS1_k127_3931193_7 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 456.0
TLS1_k127_3931193_8 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 423.0
TLS1_k127_3931193_9 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 415.0
TLS1_k127_4087444_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1555.0
TLS1_k127_4087444_1 Dehydratase family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 0.0 1009.0
TLS1_k127_4087444_10 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003244 538.0
TLS1_k127_4087444_11 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 529.0
TLS1_k127_4087444_12 homoserine dehydrogenase K00003 GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 509.0
TLS1_k127_4087444_13 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 503.0
TLS1_k127_4087444_14 Phosphohydrolase-associated domain K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 469.0
TLS1_k127_4087444_15 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 461.0
TLS1_k127_4087444_16 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 452.0
TLS1_k127_4087444_17 Fructose-1,6-bisphosphatase K02446,K11532 - 3.1.3.11,3.1.3.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 437.0
TLS1_k127_4087444_18 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 431.0
TLS1_k127_4087444_19 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 421.0
TLS1_k127_4087444_2 Copper binding proteins, plastocyanin/azurin family K00368 - 1.7.2.1 8.092e-269 844.0
TLS1_k127_4087444_20 Protein of unknown function (DUF815) K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 418.0
TLS1_k127_4087444_21 PFAM glycoside hydrolase family 3 domain protein K01207,K05349 - 3.2.1.21,3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 392.0
TLS1_k127_4087444_22 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 394.0
TLS1_k127_4087444_23 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 368.0
TLS1_k127_4087444_24 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 374.0
TLS1_k127_4087444_25 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 352.0
TLS1_k127_4087444_26 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007779 334.0
TLS1_k127_4087444_27 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 329.0
TLS1_k127_4087444_28 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 314.0
TLS1_k127_4087444_29 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 304.0
TLS1_k127_4087444_3 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 6.346e-246 772.0
TLS1_k127_4087444_30 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000125 280.0
TLS1_k127_4087444_31 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004423 274.0
TLS1_k127_4087444_32 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005124 275.0
TLS1_k127_4087444_33 Phytoene squalene synthetase K02291,K18163 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005012 273.0
TLS1_k127_4087444_34 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21564 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000228 270.0
TLS1_k127_4087444_35 Lysin motif K06194 - - 0.00000000000000000000000000000000000000000000000000000000000000003069 239.0
TLS1_k127_4087444_36 Belongs to the GST superfamily K00799 GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 2.5.1.18 0.00000000000000000000000000000000000000000000000000001008 198.0
TLS1_k127_4087444_37 Bacterial protein of unknown function (DUF898) - - - 0.0000000000000000000000000000000000000000000000000008013 199.0
TLS1_k127_4087444_38 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000000000000000000000000000000000003956 181.0
TLS1_k127_4087444_39 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000000000000000000000000000000000000009234 163.0
TLS1_k127_4087444_4 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 2.737e-235 746.0
TLS1_k127_4087444_40 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000591 171.0
TLS1_k127_4087444_41 Belongs to the HesB IscA family K13628,K15724 - - 0.000000000000000000000000000000000000000001944 157.0
TLS1_k127_4087444_42 PFAM regulatory protein MerR - - - 0.000000000000000000000000000000000000000006931 162.0
TLS1_k127_4087444_43 Ubiquinol-cytochrome C chaperone K17662 - - 0.00000000000000000000000000000000000000008221 157.0
TLS1_k127_4087444_44 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000000000000000000000000000000000002243 140.0
TLS1_k127_4087444_45 SmpA / OmlA family - - - 0.000000000000000000000000000000000006902 143.0
TLS1_k127_4087444_46 Protein of unknown function (DUF498/DUF598) - - - 0.0000000000000000000000000000000004376 138.0
TLS1_k127_4087444_47 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000000000005312 134.0
TLS1_k127_4087444_48 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000006295 130.0
TLS1_k127_4087444_49 - - - - 0.00000000000000000000000000002425 119.0
TLS1_k127_4087444_5 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 5.958e-227 710.0
TLS1_k127_4087444_50 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.0000000000000000000000000655 111.0
TLS1_k127_4087444_51 PIN domain - - - 0.00000000000000000000000006644 112.0
TLS1_k127_4087444_52 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000000000001995 109.0
TLS1_k127_4087444_53 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0003674,GO:0005215 - 0.0000000000000000000213 92.0
TLS1_k127_4087444_54 Sel1-like repeats. K07126 - - 0.0000000000000000003326 99.0
TLS1_k127_4087444_55 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 GO:0003674,GO:0005215 - 0.0000000000000000004516 91.0
TLS1_k127_4087444_56 - - - - 0.00000000000155 69.0
TLS1_k127_4087444_58 Sporulation related domain - - - 0.00000009157 66.0
TLS1_k127_4087444_59 - K21495 - - 0.00004649 48.0
TLS1_k127_4087444_6 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.006e-222 704.0
TLS1_k127_4087444_60 dehydrogenase - - - 0.0002916 46.0
TLS1_k127_4087444_7 DHH family K07462 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 1.009e-198 636.0
TLS1_k127_4087444_8 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 561.0
TLS1_k127_4087444_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003698 562.0
TLS1_k127_4149011_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 525.0
TLS1_k127_4149011_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 503.0
TLS1_k127_4149011_2 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 408.0
TLS1_k127_4149011_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 405.0
TLS1_k127_4149011_4 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 345.0
TLS1_k127_4149011_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005244 243.0
TLS1_k127_4149011_6 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000286 114.0
TLS1_k127_4153358_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 416.0
TLS1_k127_4153358_1 Uncharacterised protein family (UPF0093) K08973 - - 0.000000000000000000000000000000000000000000000000000000000002428 214.0
TLS1_k127_4153358_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000001814 191.0
TLS1_k127_4181812_0 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1750.0
TLS1_k127_4207346_0 Belongs to the glycosyl hydrolase 2 family - - - 0.0 1227.0
TLS1_k127_4207346_1 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 6.241e-303 949.0
TLS1_k127_4207346_10 Dehydrogenase K05711 - 1.3.1.87 0.000000000000000000000000000000000000000000009524 171.0
TLS1_k127_4207346_11 - - - - 0.000000000000000001291 89.0
TLS1_k127_4207346_12 Dienelactone hydrolase family - - - 0.0000000004529 62.0
TLS1_k127_4207346_2 PFAM copper amine oxidase K00276 - 1.4.3.21 2.246e-223 710.0
TLS1_k127_4207346_3 UDP-galactopyranose mutase K01854 - 5.4.99.9 1.499e-199 627.0
TLS1_k127_4207346_4 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 504.0
TLS1_k127_4207346_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 481.0
TLS1_k127_4207346_6 Binding-protein-dependent transport system inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001998 259.0
TLS1_k127_4207346_7 ABC-type spermidine putrescine transport system, permease component II K11070 - - 0.00000000000000000000000000000000000000000000000000000000001062 216.0
TLS1_k127_4207346_8 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000005933 213.0
TLS1_k127_4207346_9 KR domain - - - 0.0000000000000000000000000000000000000000000009601 175.0
TLS1_k127_4296141_0 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000000000000003593 273.0
TLS1_k127_4296141_1 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.00000000000000000000000000000000001055 140.0
TLS1_k127_4296141_2 C-terminal domain of 1-Cys peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000001203 124.0
TLS1_k127_4306731_0 Belongs to the ABC transporter superfamily K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 562.0
TLS1_k127_4306731_1 ABC-type sugar transport system, permease component K02026,K17317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 485.0
TLS1_k127_4306731_2 COG1175 ABC-type sugar transport systems permease components K17316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 474.0
TLS1_k127_4306731_3 Extracellular solute-binding protein K17315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 409.0
TLS1_k127_4306731_4 ABC-type sugar transport system, auxiliary component K09988 - 5.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 408.0
TLS1_k127_4306731_5 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 362.0
TLS1_k127_4306731_6 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006619 270.0
TLS1_k127_4306731_7 PFAM Amidohydrolase 3 - - - 0.00000000000000000000007093 106.0
TLS1_k127_4309381_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.4.2 0.0 1290.0
TLS1_k127_4309381_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.643e-246 771.0
TLS1_k127_4309381_10 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 423.0
TLS1_k127_4309381_11 Insulinase (Peptidase family M16) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 412.0
TLS1_k127_4309381_12 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 396.0
TLS1_k127_4309381_13 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004853 365.0
TLS1_k127_4309381_14 Polysaccharide biosynthesis C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 369.0
TLS1_k127_4309381_15 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179,K06125 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 359.0
TLS1_k127_4309381_16 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005715 321.0
TLS1_k127_4309381_17 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 318.0
TLS1_k127_4309381_18 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 301.0
TLS1_k127_4309381_19 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001643 289.0
TLS1_k127_4309381_2 Aminotransferase class-III K00822,K00833 - 2.6.1.18,2.6.1.62 1.134e-218 685.0
TLS1_k127_4309381_20 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001278 285.0
TLS1_k127_4309381_21 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000079 257.0
TLS1_k127_4309381_22 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000000000000000000000000000000000000000000000000000000008594 250.0
TLS1_k127_4309381_23 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000002657 248.0
TLS1_k127_4309381_24 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000001368 220.0
TLS1_k127_4309381_25 Peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001679 210.0
TLS1_k127_4309381_26 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000004088 196.0
TLS1_k127_4309381_27 Protein conserved in bacteria K09797 - - 0.0000000000000000000000000000000000000000000000000002934 193.0
TLS1_k127_4309381_28 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000001332 183.0
TLS1_k127_4309381_29 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.00000000000000000000000000000000000000000000001535 173.0
TLS1_k127_4309381_3 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 2.337e-211 665.0
TLS1_k127_4309381_30 Disulphide bond corrector protein DsbC - - - 0.000000000000000000000000000000000000000002587 165.0
TLS1_k127_4309381_31 PFAM MaoC domain protein dehydratase K17865 GO:0003674,GO:0003824,GO:0003859,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0046487,GO:0071704 4.2.1.55 0.0000000000000000000000000000000000000000348 159.0
TLS1_k127_4309381_32 SURF1 family K14998 GO:0006996,GO:0007005,GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0033108,GO:0033617,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.0000000000000000000000000000000000003536 153.0
TLS1_k127_4309381_33 Periplasmic binding protein domain K02058 - - 0.000000000000000000000000000000000003534 139.0
TLS1_k127_4309381_34 Protein of unknown function (DUF983) - - - 0.000000000000000000000000000000003133 136.0
TLS1_k127_4309381_35 Domain of unknown function (DUF4170) - - - 0.000000000000000000000000000003549 122.0
TLS1_k127_4309381_36 Putative diguanylate phosphodiesterase K13593 - - 0.0000000000000000000003334 109.0
TLS1_k127_4309381_37 Invasion associated locus B - - - 0.00000000000000000000786 102.0
TLS1_k127_4309381_38 Protein conserved in bacteria K09928 - - 0.00000000000000001225 87.0
TLS1_k127_4309381_39 Domain of unknown function (DUF1127) - - - 0.00001378 50.0
TLS1_k127_4309381_4 Diguanylate cyclase K13245 - 3.1.4.52 3.259e-205 684.0
TLS1_k127_4309381_41 Bacterial protein of unknown function (DUF937) - - - 0.0001078 52.0
TLS1_k127_4309381_42 - - - - 0.0004335 47.0
TLS1_k127_4309381_5 TIGRFAM glutamate--cysteine ligase, plant type K01919 - 6.3.2.2 1.532e-200 633.0
TLS1_k127_4309381_6 Threonine synthase K01733 GO:0003674,GO:0003824,GO:0004795,GO:0006082,GO:0006520,GO:0006566,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016311,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009359 574.0
TLS1_k127_4309381_7 Cytochrome c oxidase subunit III K02276 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007119 486.0
TLS1_k127_4309381_8 Putative modulator of DNA gyrase K03592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006754 493.0
TLS1_k127_4309381_9 Glycine cleavage system T protein K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 452.0
TLS1_k127_4399585_0 Bacterial type II and III secretion system protein K02280 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 403.0
TLS1_k127_4399585_1 pilus assembly protein CpaB K02279 - - 0.0000000000000000000000000000000000000000000000000000000000009766 218.0
TLS1_k127_4399585_2 Type IV leader peptidase family K02278 - 3.4.23.43 0.000000000000000000000000005169 117.0
TLS1_k127_4399585_3 Flp Fap pilin component K02651 - - 0.00000000119 60.0
TLS1_k127_4467237_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 2.439e-197 624.0
TLS1_k127_4467237_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 531.0
TLS1_k127_4467237_2 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 347.0
TLS1_k127_4480960_0 P-type ATPase' K17686 - 3.6.3.54 0.0 1135.0
TLS1_k127_4480960_1 ABC transporter K06158 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 1.192e-229 728.0
TLS1_k127_4480960_10 ABC-type polar amino acid transport system ATPase component K02028 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 355.0
TLS1_k127_4480960_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 359.0
TLS1_k127_4480960_12 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 342.0
TLS1_k127_4480960_13 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 338.0
TLS1_k127_4480960_14 cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 314.0
TLS1_k127_4480960_15 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005023 275.0
TLS1_k127_4480960_16 stress-induced protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001916 278.0
TLS1_k127_4480960_17 DNA polymerase III chi subunit, HolC K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000005604 199.0
TLS1_k127_4480960_18 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000000000000003382 147.0
TLS1_k127_4480960_19 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000004134 132.0
TLS1_k127_4480960_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 1.143e-204 643.0
TLS1_k127_4480960_20 malonyl CoA-acyl carrier protein transacylase K00645,K15327 - 2.3.1.39 0.00000000000000000000000000000001573 129.0
TLS1_k127_4480960_21 SurA N-terminal domain K03771 - 5.2.1.8 0.000000000000000000000000008031 122.0
TLS1_k127_4480960_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007303 587.0
TLS1_k127_4480960_4 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 467.0
TLS1_k127_4480960_5 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 426.0
TLS1_k127_4480960_6 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 413.0
TLS1_k127_4480960_7 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 407.0
TLS1_k127_4480960_8 Zinc-binding dehydrogenase K00001,K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 367.0
TLS1_k127_4480960_9 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 354.0
TLS1_k127_4481222_0 - K03418 - 3.5.1.56 0.0 1011.0
TLS1_k127_4481222_1 ABC transporter substrate-binding protein K02027 - - 1.731e-314 968.0
TLS1_k127_4481222_10 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009481 487.0
TLS1_k127_4481222_11 HWE histidine kinase K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 474.0
TLS1_k127_4481222_12 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 411.0
TLS1_k127_4481222_13 phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 394.0
TLS1_k127_4481222_14 BtpA family K06971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 377.0
TLS1_k127_4481222_15 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 384.0
TLS1_k127_4481222_16 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005679 363.0
TLS1_k127_4481222_17 Belongs to the UPF0276 family K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 361.0
TLS1_k127_4481222_18 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004196 359.0
TLS1_k127_4481222_19 very-long-chain-acyl-CoA dehydrogenase activity K17880,K18817 - 2.7.1.119,2.7.1.163 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006812 352.0
TLS1_k127_4481222_2 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 588.0
TLS1_k127_4481222_20 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 344.0
TLS1_k127_4481222_21 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 317.0
TLS1_k127_4481222_22 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 311.0
TLS1_k127_4481222_23 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 295.0
TLS1_k127_4481222_24 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 286.0
TLS1_k127_4481222_25 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007019 280.0
TLS1_k127_4481222_26 COG1073 hydrolases of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004134 268.0
TLS1_k127_4481222_27 RbsD / FucU transport protein family K02431 - 5.1.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000003055 245.0
TLS1_k127_4481222_28 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005768 250.0
TLS1_k127_4481222_29 Bacterial SH3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003005 235.0
TLS1_k127_4481222_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 572.0
TLS1_k127_4481222_30 peroxiredoxin activity K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000003817 244.0
TLS1_k127_4481222_31 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000008717 231.0
TLS1_k127_4481222_32 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000000000000000000000000000000000002567 221.0
TLS1_k127_4481222_33 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000655 231.0
TLS1_k127_4481222_34 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000904 226.0
TLS1_k127_4481222_35 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000000000000000000000000000000000000000000001646 181.0
TLS1_k127_4481222_36 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000000002205 183.0
TLS1_k127_4481222_37 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000007045 194.0
TLS1_k127_4481222_38 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000001529 168.0
TLS1_k127_4481222_39 periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000006915 168.0
TLS1_k127_4481222_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 575.0
TLS1_k127_4481222_40 - - - - 0.0000000000000000000000000000000000000000009522 158.0
TLS1_k127_4481222_41 PFAM DoxX family protein K15977 - - 0.000000000000000000000000000000000000000007922 158.0
TLS1_k127_4481222_42 protein conserved in bacteria - - - 0.000000000000000000000000000000000001187 149.0
TLS1_k127_4481222_43 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000009926 152.0
TLS1_k127_4481222_44 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000006556 135.0
TLS1_k127_4481222_45 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000000007871 143.0
TLS1_k127_4481222_46 Predicted integral membrane protein (DUF2282) - - - 0.0000000000000000000000000000000003226 135.0
TLS1_k127_4481222_47 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000002525 98.0
TLS1_k127_4481222_48 - - - - 0.0000000000000002119 82.0
TLS1_k127_4481222_49 - - - - 0.000000000001178 71.0
TLS1_k127_4481222_5 Creatinase/Prolidase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 560.0
TLS1_k127_4481222_50 - - - - 0.000000000003918 74.0
TLS1_k127_4481222_51 PilZ domain - - - 0.00000001487 59.0
TLS1_k127_4481222_52 - - - - 0.00004021 52.0
TLS1_k127_4481222_53 - - - - 0.0001742 47.0
TLS1_k127_4481222_6 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 536.0
TLS1_k127_4481222_7 Belongs to the ABC transporter superfamily K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007804 530.0
TLS1_k127_4481222_8 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009908 532.0
TLS1_k127_4481222_9 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 525.0
TLS1_k127_4497104_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 6.25e-263 823.0
TLS1_k127_4497104_1 Aerotolerance regulator N-terminal - - - 3.443e-256 819.0
TLS1_k127_4497104_10 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 353.0
TLS1_k127_4497104_11 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009984 335.0
TLS1_k127_4497104_12 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 297.0
TLS1_k127_4497104_13 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 291.0
TLS1_k127_4497104_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001004 276.0
TLS1_k127_4497104_15 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002337 270.0
TLS1_k127_4497104_16 Two component transcriptional regulator K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002671 261.0
TLS1_k127_4497104_17 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000699 252.0
TLS1_k127_4497104_18 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000002282 246.0
TLS1_k127_4497104_19 Protein of unknown function (DUF1285) K09986 - - 0.000000000000000000000000000000000000000000000000000000000000000002046 231.0
TLS1_k127_4497104_2 Rieske [2Fe-2S] domain - - - 2.812e-226 716.0
TLS1_k127_4497104_20 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000000298 221.0
TLS1_k127_4497104_21 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000000000000002828 198.0
TLS1_k127_4497104_22 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000001861 189.0
TLS1_k127_4497104_23 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000002209 185.0
TLS1_k127_4497104_24 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000004351 181.0
TLS1_k127_4497104_25 Putative tRNA binding domain K06878 GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0017101,GO:0017102,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000004842 181.0
TLS1_k127_4497104_26 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000001229 165.0
TLS1_k127_4497104_27 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000000554 137.0
TLS1_k127_4497104_28 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000001138 124.0
TLS1_k127_4497104_29 Protein of unknown function (DUF861) K06995 - - 0.000000000000000000000000003207 116.0
TLS1_k127_4497104_3 membrane - - - 4.562e-220 702.0
TLS1_k127_4497104_30 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000115 117.0
TLS1_k127_4497104_31 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000000000000000000000001696 107.0
TLS1_k127_4497104_32 Membrane fusogenic activity K09806 - - 0.0000000000000000000004754 101.0
TLS1_k127_4497104_33 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000001052 82.0
TLS1_k127_4497104_34 - - - - 0.00009516 52.0
TLS1_k127_4497104_4 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008684 522.0
TLS1_k127_4497104_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 504.0
TLS1_k127_4497104_6 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 480.0
TLS1_k127_4497104_7 ATPase family associated with various cellular activities (AAA) K03924 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009777 456.0
TLS1_k127_4497104_8 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07638 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 449.0
TLS1_k127_4497104_9 Putative S-adenosyl-L-methionine-dependent methyltransferase K00574,K18164 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 366.0
TLS1_k127_4503345_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000007774 158.0
TLS1_k127_4503345_1 Belongs to the bacterial histone-like protein family K03530 - - 0.0000000000000000000000000000000000000006546 150.0
TLS1_k127_4503345_2 bacterial (prokaryotic) histone like domain K03530 - - 0.00000000000000000000000000000001136 130.0
TLS1_k127_4503345_4 - - - - 0.00003852 47.0
TLS1_k127_4507708_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K18983 - 5.5.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009798 466.0
TLS1_k127_4507708_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 348.0
TLS1_k127_4507708_2 Secretory lipase - - - 0.0000000000000000696 82.0
TLS1_k127_4521457_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 518.0
TLS1_k127_4521457_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004334 279.0
TLS1_k127_4521457_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000001067 158.0
TLS1_k127_4762489_0 Leucyl-tRNA synthetase, Domain 2 K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1154.0
TLS1_k127_4762489_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 363.0
TLS1_k127_4762489_10 Cyclic nucleotide-binding domain - - - 0.000000000000000000001548 100.0
TLS1_k127_4762489_11 Lipopolysaccharide-assembly K03643 - - 0.000000000000000004404 90.0
TLS1_k127_4762489_2 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 365.0
TLS1_k127_4762489_3 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 337.0
TLS1_k127_4762489_4 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 314.0
TLS1_k127_4762489_5 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 286.0
TLS1_k127_4762489_6 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001318 228.0
TLS1_k127_4762489_7 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000002068 207.0
TLS1_k127_4762489_8 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000000001036 157.0
TLS1_k127_4762489_9 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.000000000000000000000000001257 114.0
TLS1_k127_476821_0 Dehydratase large subunit K01699 - 4.2.1.28 0.0 1208.0
TLS1_k127_476821_1 UDP-glucoronosyl and UDP-glucosyl transferase - - - 6.941e-229 716.0
TLS1_k127_476821_10 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 474.0
TLS1_k127_476821_11 spermidine putrescine K02054 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008278 464.0
TLS1_k127_476821_12 TIGRFAM 6-phosphogluconate dehydrogenase (decarboxylating) K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 442.0
TLS1_k127_476821_13 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 425.0
TLS1_k127_476821_14 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009692 426.0
TLS1_k127_476821_15 PFAM Tripartite tricarboxylate transporter family receptor K07795 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 417.0
TLS1_k127_476821_16 Binding-protein-dependent transport system inner membrane component K02053,K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 412.0
TLS1_k127_476821_17 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004094 411.0
TLS1_k127_476821_18 Binding-protein-dependent transport system inner membrane component K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 398.0
TLS1_k127_476821_19 ATPases associated with a variety of cellular activities K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009911 390.0
TLS1_k127_476821_2 PFAM Tripartite tricarboxylate transporter TctA family K07793 - - 1.716e-218 691.0
TLS1_k127_476821_20 Binding-protein-dependent transport system inner membrane component K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 361.0
TLS1_k127_476821_21 membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 331.0
TLS1_k127_476821_22 PFAM Bacterial extracellular solute-binding proteins, family 3 K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 310.0
TLS1_k127_476821_23 Carbon dioxide concentrating mechanism carboxysome shell protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 283.0
TLS1_k127_476821_24 BMC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001985 278.0
TLS1_k127_476821_25 Polar amino acid uptake family ABC transporter, permease protein K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002019 273.0
TLS1_k127_476821_26 ABC-type arginine transport system, permease component K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004512 254.0
TLS1_k127_476821_27 TOBE domain K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000105 231.0
TLS1_k127_476821_28 MafB19-like deaminase - - - 0.000000000000000000000000000000000000000000000000000000000004169 219.0
TLS1_k127_476821_29 Protein of unknown function (DUF861) K06995 - - 0.0000000000000000000000000000000000000000000000000000001579 198.0
TLS1_k127_476821_3 Bacterial extracellular solute-binding protein K02055 - - 1.814e-210 660.0
TLS1_k127_476821_30 Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000000000000000000000000000000000000002877 197.0
TLS1_k127_476821_31 Dehydratase small subunit K13920 - 4.2.1.28 0.00000000000000000000000000000000000000000000001841 174.0
TLS1_k127_476821_32 BMC - - - 0.000000000000000000000000000000002308 130.0
TLS1_k127_476821_33 Tripartite tricarboxylate transporter TctB family K07794 - - 0.00000000000000000000000203 108.0
TLS1_k127_476821_34 Ethanolamine utilization protein EutN K04028 - - 0.000000000000000003871 93.0
TLS1_k127_476821_35 - - - - 0.00000000007689 69.0
TLS1_k127_476821_4 Bacterial extracellular solute-binding protein K11069 - - 1.729e-195 614.0
TLS1_k127_476821_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 579.0
TLS1_k127_476821_6 TOBE domain K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 522.0
TLS1_k127_476821_7 Aldehyde dehydrogenase family K13922 - 1.2.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 527.0
TLS1_k127_476821_8 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 507.0
TLS1_k127_476821_9 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 499.0
TLS1_k127_478403_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1242.0
TLS1_k127_478403_1 Pyridoxal-phosphate dependent enzyme K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006692 539.0
TLS1_k127_478403_10 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 346.0
TLS1_k127_478403_11 Threonyl and Alanyl tRNA synthetase second additional domain K07050 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 329.0
TLS1_k127_478403_12 Sulfotransferase domain K01014 - 2.8.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 317.0
TLS1_k127_478403_13 Carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008306 274.0
TLS1_k127_478403_14 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000002567 228.0
TLS1_k127_478403_15 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000003421 193.0
TLS1_k127_478403_16 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000007357 185.0
TLS1_k127_478403_17 Thioredoxin - - - 0.000000000000000000000000000000000000000005734 164.0
TLS1_k127_478403_18 HupE / UreJ protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000001552 129.0
TLS1_k127_478403_19 CreA protein K05805 - - 0.00000000000000000000000000006367 119.0
TLS1_k127_478403_2 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K09969 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000481 503.0
TLS1_k127_478403_20 - - - - 0.0000000000000000002123 91.0
TLS1_k127_478403_22 Protein of unknown function (DUF2497) K09991 - - 0.000000000000004274 86.0
TLS1_k127_478403_23 SnoaL-like domain K06893 - - 0.00000000000007426 77.0
TLS1_k127_478403_24 Flp Fap pilin component K02651 - - 0.00000002746 56.0
TLS1_k127_478403_25 Hydrogenase urease accessory protein K03192 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000001134 58.0
TLS1_k127_478403_27 protein conserved in bacteria K09796 - - 0.0005941 48.0
TLS1_k127_478403_3 PFAM Cys Met metabolism PLP-dependent enzyme K01760 GO:0000096,GO:0000098,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004121,GO:0006082,GO:0006090,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0046483,GO:0047804,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1990414 4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009682 456.0
TLS1_k127_478403_4 ABC-type polar amino acid transport system ATPase component K02028,K09972 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 447.0
TLS1_k127_478403_5 Chalcone and stilbene synthases, C-terminal domain K16167 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006166 439.0
TLS1_k127_478403_6 amino acid ABC K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 420.0
TLS1_k127_478403_7 ABC-type amino acid transport system permease component K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 417.0
TLS1_k127_478403_8 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 362.0
TLS1_k127_478403_9 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 352.0
TLS1_k127_483717_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.786e-297 917.0
TLS1_k127_483717_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 9.838e-237 738.0
TLS1_k127_483717_10 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162,K00627 - 1.2.4.1,2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 485.0
TLS1_k127_483717_11 Glycosyl transferase family, helical bundle domain K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 448.0
TLS1_k127_483717_12 Domain of unknown function (DUF4131) K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 437.0
TLS1_k127_483717_13 Peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 424.0
TLS1_k127_483717_14 MoeA C-terminal region (domain IV) K03750 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 410.0
TLS1_k127_483717_15 FAD dependent oxidoreductase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 409.0
TLS1_k127_483717_16 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 363.0
TLS1_k127_483717_17 Belongs to the TrpC family K01609,K13498 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005783 344.0
TLS1_k127_483717_18 Mechanosensitive ion channel K05802 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 349.0
TLS1_k127_483717_19 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007071 298.0
TLS1_k127_483717_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 1.241e-232 726.0
TLS1_k127_483717_20 Anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001651 279.0
TLS1_k127_483717_21 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000000000000000001627 243.0
TLS1_k127_483717_22 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002205 250.0
TLS1_k127_483717_23 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000188 241.0
TLS1_k127_483717_24 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000001273 216.0
TLS1_k127_483717_25 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000002202 209.0
TLS1_k127_483717_26 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000001019 207.0
TLS1_k127_483717_27 Required for the activity of the bacterial periplasmic transport system of putrescine K11073 - - 0.0000000000000000000000000000000000000001924 162.0
TLS1_k127_483717_28 Transcriptional regulator - - - 0.000000000000000000000000005781 115.0
TLS1_k127_483717_29 Transglycosylase associated protein - - - 0.00000000000000000000000003875 109.0
TLS1_k127_483717_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 1.61e-221 696.0
TLS1_k127_483717_30 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000000007254 110.0
TLS1_k127_483717_31 oligoketide cyclase lipid transport protein K18588 - - 0.00000000000000000000001118 107.0
TLS1_k127_483717_32 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.00000000000000000005235 92.0
TLS1_k127_483717_33 Transglycosylase SLT domain - - - 0.0000000000000000005266 93.0
TLS1_k127_483717_34 Transglycosylase associated protein - - - 0.00000000000000000232 88.0
TLS1_k127_483717_35 Septum formation initiator - - - 0.000001128 54.0
TLS1_k127_483717_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.718e-213 671.0
TLS1_k127_483717_5 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 4.751e-211 665.0
TLS1_k127_483717_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 2.337e-206 650.0
TLS1_k127_483717_7 Sodium proton antiporter, NhaD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 547.0
TLS1_k127_483717_8 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 533.0
TLS1_k127_483717_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 524.0
TLS1_k127_4919543_0 Belongs to the glycosyl hydrolase 2 family - - - 1.06e-290 919.0
TLS1_k127_4919543_1 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 5.861e-231 723.0
TLS1_k127_4919543_10 Stress-induced bacterial acidophilic repeat motif K06884 - - 0.000000000000002288 78.0
TLS1_k127_4919543_11 Stress-induced bacterial acidophilic repeat motif - - - 0.000001046 54.0
TLS1_k127_4919543_12 - - - - 0.00005518 49.0
TLS1_k127_4919543_2 beta-glucosidase - - - 4.015e-211 664.0
TLS1_k127_4919543_3 Belongs to the glycosyl hydrolase 1 family - - - 3.201e-198 631.0
TLS1_k127_4919543_4 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 481.0
TLS1_k127_4919543_5 Lytic murein transglycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901 340.0
TLS1_k127_4919543_6 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009124 311.0
TLS1_k127_4919543_7 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001643 278.0
TLS1_k127_4919543_8 Stress-induced bacterial acidophilic repeat motif K06884 - - 0.00000000000000000000002009 104.0
TLS1_k127_4919543_9 Aminoacyl-tRNA editing domain K01284 - 3.4.15.5 0.00000000000000000000003122 103.0
TLS1_k127_4924377_0 Carboxyl transferase domain K01966 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0031974,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0070013,GO:0071704,GO:0072329,GO:1901575 2.1.3.15,6.4.1.3 4.525e-283 875.0
TLS1_k127_4924377_1 Biotin carboxylase C-terminal domain K01965 GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681 6.4.1.3 1.196e-276 865.0
TLS1_k127_4924377_10 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000004181 87.0
TLS1_k127_4924377_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 2.976e-205 648.0
TLS1_k127_4924377_3 RNA pseudouridylate synthase K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 336.0
TLS1_k127_4924377_4 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 304.0
TLS1_k127_4924377_5 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000773 246.0
TLS1_k127_4924377_6 ATP12 chaperone protein - - - 0.00000000000000000000000000000000000000000000000000000000000000006647 229.0
TLS1_k127_4924377_7 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000008199 168.0
TLS1_k127_4924377_8 ChrR Cupin-like domain - - - 0.0000000000000000000000000000003534 126.0
TLS1_k127_4924377_9 Uncharacterized protein conserved in bacteria (DUF2199) - - - 0.000000000000000000000000001503 118.0
TLS1_k127_5034465_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 571.0
TLS1_k127_5034465_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000005426 231.0
TLS1_k127_5034465_2 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.00000000000000000000000000001365 120.0
TLS1_k127_5044638_0 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008714,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464 3.2.2.4 9.237e-234 733.0
TLS1_k127_5044638_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005903 476.0
TLS1_k127_5044638_2 ubiquitin protein ligase binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 394.0
TLS1_k127_5044638_3 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000007732 207.0
TLS1_k127_5044638_4 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000001024 200.0
TLS1_k127_5044638_5 Domain of unknown function (DUF1993) - - - 0.000000000000000000000000000000000000000000000000001513 194.0
TLS1_k127_5044638_6 Protein required for attachment to host - - - 0.0000000000000000000000000000000001233 138.0
TLS1_k127_5044638_7 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000000000000009799 86.0
TLS1_k127_505180_0 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 477.0
TLS1_k127_505180_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000002272 257.0
TLS1_k127_5125827_0 ErfK YbiS YcfS YnhG family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 312.0
TLS1_k127_5125827_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 291.0
TLS1_k127_5125827_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008068 279.0
TLS1_k127_5125827_3 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001838 278.0
TLS1_k127_5125827_4 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009251 277.0
TLS1_k127_5125827_5 Alkylated DNA repair protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002348 252.0
TLS1_k127_5125827_6 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000006844 225.0
TLS1_k127_5125827_7 hyperosmotic response - - - 0.000000000000000000000000000000000000000000000000000001717 197.0
TLS1_k127_5125827_8 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000001649 139.0
TLS1_k127_5125827_9 FecR protein - - - 0.000000000000000000000000002706 119.0
TLS1_k127_5140220_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1222.0
TLS1_k127_5140220_1 C-terminal, D2-small domain, of ClpB protein K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.0 1199.0
TLS1_k127_5140220_10 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 514.0
TLS1_k127_5140220_11 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000736 510.0
TLS1_k127_5140220_12 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 404.0
TLS1_k127_5140220_13 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 397.0
TLS1_k127_5140220_14 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005329 382.0
TLS1_k127_5140220_15 D-alanyl-D-alanine carboxypeptidase K01286,K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 344.0
TLS1_k127_5140220_16 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 339.0
TLS1_k127_5140220_17 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 323.0
TLS1_k127_5140220_18 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 317.0
TLS1_k127_5140220_19 Pantoate-beta-alanine ligase K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006116 291.0
TLS1_k127_5140220_2 Bacterial DNA topoisomeraes I ATP-binding domain K03168 - 5.99.1.2 0.0 1133.0
TLS1_k127_5140220_20 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 290.0
TLS1_k127_5140220_21 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006903 277.0
TLS1_k127_5140220_22 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000003225 256.0
TLS1_k127_5140220_23 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000006837 255.0
TLS1_k127_5140220_24 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000000000000000000000000000000000000003722 210.0
TLS1_k127_5140220_25 cheY-homologous receiver domain K11443 - - 0.0000000000000000000000000000000000000000000000000000000008022 203.0
TLS1_k127_5140220_26 BioY family K03523 - - 0.0000000000000000000000000000000000000000000000000000000298 203.0
TLS1_k127_5140220_27 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000000000001189 187.0
TLS1_k127_5140220_28 Mrr N-terminal domain K07448 - - 0.000000000000000000000000000000000000000000000000006056 192.0
TLS1_k127_5140220_29 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.0000000000000000000000000000000000000000000000001165 191.0
TLS1_k127_5140220_3 Carboxyl transferase domain K01969 - 6.4.1.4 6.161e-255 794.0
TLS1_k127_5140220_30 Domain of unknown function (DUF1849) - - - 0.00000000000000000000000000000000000000000000001679 181.0
TLS1_k127_5140220_31 PFAM heat shock protein DnaJ domain protein - - - 0.00000000000000000000000000000000000000000000003212 180.0
TLS1_k127_5140220_32 PFAM conserved - - - 0.00000000000000000000000000000000000000001439 157.0
TLS1_k127_5140220_33 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000000000000001511 161.0
TLS1_k127_5140220_34 AzlC protein - - - 0.000000000000000000000000000000000000004427 155.0
TLS1_k127_5140220_35 HutD K09975 - - 0.0000000000000000000000000000000001003 139.0
TLS1_k127_5140220_36 - - - - 0.000000000000000000000000000002803 123.0
TLS1_k127_5140220_37 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000319 108.0
TLS1_k127_5140220_38 Belongs to the bacterial ribosomal protein bL33 family K02913 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000003579 96.0
TLS1_k127_5140220_39 Phasin protein - - - 0.0000000000000000000003584 100.0
TLS1_k127_5140220_4 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 4.989e-244 774.0
TLS1_k127_5140220_40 Acetyltransferase (GNAT) family - - - 0.00000000000000003878 88.0
TLS1_k127_5140220_41 Protein of unknown function (DUF3572) - - - 0.0000000000001519 77.0
TLS1_k127_5140220_42 EF hand - - - 0.00000000002206 73.0
TLS1_k127_5140220_43 Branched-chain amino acid transport protein (AzlD) - - - 0.00000008294 59.0
TLS1_k127_5140220_5 Tripartite ATP-independent periplasmic transporter, DctM component - - - 8.064e-238 751.0
TLS1_k127_5140220_6 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 1.492e-199 626.0
TLS1_k127_5140220_7 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006622 553.0
TLS1_k127_5140220_8 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 536.0
TLS1_k127_5140220_9 diguanylate cyclase K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 536.0
TLS1_k127_5162511_0 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1371.0
TLS1_k127_5162511_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 4.548e-285 893.0
TLS1_k127_5162511_10 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006364 387.0
TLS1_k127_5162511_11 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 382.0
TLS1_k127_5162511_12 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 330.0
TLS1_k127_5162511_13 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 320.0
TLS1_k127_5162511_14 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 310.0
TLS1_k127_5162511_15 O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 296.0
TLS1_k127_5162511_16 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 287.0
TLS1_k127_5162511_17 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 286.0
TLS1_k127_5162511_18 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007497 284.0
TLS1_k127_5162511_19 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007444 281.0
TLS1_k127_5162511_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 6.752e-212 682.0
TLS1_k127_5162511_20 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000006906 247.0
TLS1_k127_5162511_21 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000007658 226.0
TLS1_k127_5162511_22 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000528 226.0
TLS1_k127_5162511_23 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.0000000000000000000000000000000000000000000000000000000002744 206.0
TLS1_k127_5162511_24 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000002292 204.0
TLS1_k127_5162511_25 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000000000000000000008685 193.0
TLS1_k127_5162511_26 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000002983 192.0
TLS1_k127_5162511_27 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000000000000000000238 162.0
TLS1_k127_5162511_28 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000007399 137.0
TLS1_k127_5162511_29 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000000000000000003132 128.0
TLS1_k127_5162511_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 1.593e-203 644.0
TLS1_k127_5162511_30 NADH ubiquinone oxidoreductase 41 kD complex I subunit K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000006149 109.0
TLS1_k127_5162511_31 Protein of unknown function (DUF1467) - - - 0.0000000000000001477 87.0
TLS1_k127_5162511_4 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 485.0
TLS1_k127_5162511_5 Ribosomal protein S2 K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 436.0
TLS1_k127_5162511_6 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 417.0
TLS1_k127_5162511_7 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 428.0
TLS1_k127_5162511_8 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 407.0
TLS1_k127_5162511_9 Predicted membrane protein (DUF2339) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 426.0
TLS1_k127_5193036_0 Phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1305.0
TLS1_k127_5193036_1 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.0 1257.0
TLS1_k127_5193036_10 Glucose / Sorbosone dehydrogenase K00117,K21430 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 505.0
TLS1_k127_5193036_11 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 489.0
TLS1_k127_5193036_12 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 484.0
TLS1_k127_5193036_13 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 457.0
TLS1_k127_5193036_14 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008387 443.0
TLS1_k127_5193036_15 Consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 436.0
TLS1_k127_5193036_16 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 436.0
TLS1_k127_5193036_17 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 434.0
TLS1_k127_5193036_18 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 419.0
TLS1_k127_5193036_19 metabolite transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 389.0
TLS1_k127_5193036_2 COG1180 Pyruvate-formate lyase-activating enzyme K20449 - 1.3.7.1 2.446e-251 786.0
TLS1_k127_5193036_20 Lactonase, 7-bladed beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 325.0
TLS1_k127_5193036_21 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 310.0
TLS1_k127_5193036_22 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K09740 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 313.0
TLS1_k127_5193036_23 Amino acid synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 306.0
TLS1_k127_5193036_24 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 310.0
TLS1_k127_5193036_25 ABC transporter substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 311.0
TLS1_k127_5193036_26 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 299.0
TLS1_k127_5193036_27 Flavodoxin-like fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 292.0
TLS1_k127_5193036_28 Truncated hemoglobins K06886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000133 283.0
TLS1_k127_5193036_29 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000002105 268.0
TLS1_k127_5193036_3 Amidohydrolase family K15358 - 3.5.2.18 9.694e-217 677.0
TLS1_k127_5193036_30 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001509 271.0
TLS1_k127_5193036_31 Branched-chain amino acid aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001622 262.0
TLS1_k127_5193036_32 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000005272 253.0
TLS1_k127_5193036_33 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000001274 229.0
TLS1_k127_5193036_34 Protein of unknown function (DUF1134) - - - 0.000000000000000000000000000000000000000000000000000000000000001507 224.0
TLS1_k127_5193036_35 Histidine phosphotransferase C-terminal domain K13588 - - 0.000000000000000000000000000000000000000000000000000000000001055 216.0
TLS1_k127_5193036_36 PP-loop superfamily ATPase - - - 0.000000000000000000000000000000000000000000000000000000005701 205.0
TLS1_k127_5193036_37 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000000000000000004058 200.0
TLS1_k127_5193036_38 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000002384 199.0
TLS1_k127_5193036_39 - - - - 0.00000000000000000000000000000000000000000000000000001616 197.0
TLS1_k127_5193036_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 5.77e-209 656.0
TLS1_k127_5193036_40 Flavodoxin-like fold K03923,K11748 - - 0.0000000000000000000000000000000000000000000000000000218 194.0
TLS1_k127_5193036_41 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000000002674 185.0
TLS1_k127_5193036_42 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000000000000000000000000000000000000003564 180.0
TLS1_k127_5193036_43 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000002882 170.0
TLS1_k127_5193036_44 Protein of unknown function (DUF1153) - - - 0.00000000000000000000000000000000000000000001695 163.0
TLS1_k127_5193036_45 helix_turn_helix multiple antibiotic resistance protein K22296 - - 0.00000000000000000000000000000000000000006517 156.0
TLS1_k127_5193036_46 Transglycosylase associated protein - - - 0.0000000000000000000000000000000000000002691 150.0
TLS1_k127_5193036_47 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000003095 154.0
TLS1_k127_5193036_48 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000000000000003736 154.0
TLS1_k127_5193036_49 Uncharacterized conserved protein (DUF2267) - - - 0.00000000000000000000000000000004427 130.0
TLS1_k127_5193036_5 TrkA-N domain K11745 - - 5.867e-198 635.0
TLS1_k127_5193036_50 transmembrane signaling receptor activity K03406,K13243 - 3.1.4.52 0.00000000000000000000000003271 113.0
TLS1_k127_5193036_51 Protein of unknown function (DUF1203) - - - 0.000000000000000000000004114 107.0
TLS1_k127_5193036_52 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000001082 98.0
TLS1_k127_5193036_53 flagellar export protein FliJ - - - 0.0000000000000000005795 92.0
TLS1_k127_5193036_54 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0000000000000001071 86.0
TLS1_k127_5193036_55 Transposase - - - 0.00000000000001111 86.0
TLS1_k127_5193036_56 Cytochrome b/b6/petB - - - 0.00000000004159 68.0
TLS1_k127_5193036_57 - - - - 0.0000001187 61.0
TLS1_k127_5193036_58 Domain of unknown function (DUF4339) - - - 0.0001035 53.0
TLS1_k127_5193036_59 Outer membrane protein beta-barrel domain - - - 0.0001645 51.0
TLS1_k127_5193036_6 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 566.0
TLS1_k127_5193036_7 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 528.0
TLS1_k127_5193036_8 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009351 548.0
TLS1_k127_5193036_9 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 512.0
TLS1_k127_5300086_0 AMP-binding enzyme K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 603.0
TLS1_k127_5300086_1 Cys/Met metabolism PLP-dependent enzyme K00652,K00654 - 2.3.1.47,2.3.1.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007803 507.0
TLS1_k127_5300086_10 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 293.0
TLS1_k127_5300086_11 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000001175 251.0
TLS1_k127_5300086_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001769 247.0
TLS1_k127_5300086_13 MobA-like NTP transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001134 235.0
TLS1_k127_5300086_14 Transition state regulatory protein AbrB K07120 - - 0.000000000000000000000000000000000000000000000000000000000000000001286 245.0
TLS1_k127_5300086_15 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.0000000000000000000000000000000000000000000000000000000000000000186 231.0
TLS1_k127_5300086_16 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000001585 218.0
TLS1_k127_5300086_17 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000006238 209.0
TLS1_k127_5300086_18 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000003496 201.0
TLS1_k127_5300086_19 MobA-like NTP transferase domain - - - 0.00000000000000000000000000000000000000000000002211 181.0
TLS1_k127_5300086_2 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 436.0
TLS1_k127_5300086_20 Histidine triad (HIT) protein - - - 0.0000000000000000000000000000000000000000000005358 170.0
TLS1_k127_5300086_21 Nudix hydrolase - - - 0.0000000000000000000000000000000000000003095 154.0
TLS1_k127_5300086_22 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000000009041 156.0
TLS1_k127_5300086_23 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000003047 149.0
TLS1_k127_5300086_24 MaoC like domain - - - 0.00000000000000000002849 96.0
TLS1_k127_5300086_25 Phosphopantetheine attachment site K02078 - - 0.000000000000002676 83.0
TLS1_k127_5300086_26 Phosphopantetheine attachment site - - - 0.0000000000001373 74.0
TLS1_k127_5300086_27 - - - - 0.0000006073 56.0
TLS1_k127_5300086_3 Beta-ketoacyl synthase, C-terminal domain K14660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 417.0
TLS1_k127_5300086_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000844 408.0
TLS1_k127_5300086_5 PFAM Integral membrane protein TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 351.0
TLS1_k127_5300086_6 ABC transporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 361.0
TLS1_k127_5300086_7 Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 328.0
TLS1_k127_5300086_8 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 329.0
TLS1_k127_5300086_9 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 319.0
TLS1_k127_5360070_0 Oxidoreductase family, C-terminal alpha/beta domain - - - 5.993e-204 638.0
TLS1_k127_5360070_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 524.0
TLS1_k127_5360070_2 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 404.0
TLS1_k127_5428917_0 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.0 1819.0
TLS1_k127_5428917_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0 1090.0
TLS1_k127_5428917_10 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 521.0
TLS1_k127_5428917_11 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 506.0
TLS1_k127_5428917_12 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01928,K01929,K15792 - 6.3.2.10,6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 499.0
TLS1_k127_5428917_13 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 404.0
TLS1_k127_5428917_14 Cell wall formation K00075,K01921 - 1.3.1.98,6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006673 407.0
TLS1_k127_5428917_15 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 400.0
TLS1_k127_5428917_16 Cell cycle protein K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000656 402.0
TLS1_k127_5428917_17 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 391.0
TLS1_k127_5428917_18 reductase K00297 GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 371.0
TLS1_k127_5428917_19 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 361.0
TLS1_k127_5428917_2 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 2.477e-284 889.0
TLS1_k127_5428917_20 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 360.0
TLS1_k127_5428917_21 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 342.0
TLS1_k127_5428917_22 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 312.0
TLS1_k127_5428917_23 Negative regulator of beta-lactamase expression K00788,K01447,K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 2.5.1.3,3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 307.0
TLS1_k127_5428917_24 Psort location CytoplasmicMembrane, score 10.00 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 304.0
TLS1_k127_5428917_25 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 301.0
TLS1_k127_5428917_26 molecular chaperone K05801 - - 0.000000000000000000000000000000000000000000000000000000000000000000007947 241.0
TLS1_k127_5428917_27 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000007679 230.0
TLS1_k127_5428917_28 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000001148 216.0
TLS1_k127_5428917_29 Essential cell division protein K03589 - - 0.0000000000000000000000000000000000000000001183 170.0
TLS1_k127_5428917_3 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 3.143e-222 699.0
TLS1_k127_5428917_30 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000002808 119.0
TLS1_k127_5428917_31 Branched-chain amino acid transport protein (AzlD) - - - 0.0000000000000000002823 94.0
TLS1_k127_5428917_32 - - - - 0.000000000000000001022 90.0
TLS1_k127_5428917_33 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.000000000000009681 82.0
TLS1_k127_5428917_34 secreted (Periplasmic) protein - - - 0.000000000002132 74.0
TLS1_k127_5428917_35 Domain of unknown function (DUF1127) - - - 0.0001398 49.0
TLS1_k127_5428917_4 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 9.013e-219 695.0
TLS1_k127_5428917_5 Cell division protein FtsI penicillin-binding protein 2 K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 588.0
TLS1_k127_5428917_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 552.0
TLS1_k127_5428917_7 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 543.0
TLS1_k127_5428917_8 PFAM Major Facilitator Superfamily - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008039 534.0
TLS1_k127_5428917_9 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 521.0
TLS1_k127_581392_0 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 425.0
TLS1_k127_581392_1 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000127 189.0
TLS1_k127_581392_2 - - - - 0.0000000000000000000000000000000001585 137.0
TLS1_k127_581392_3 - - - - 0.0000000000000000000000000001046 120.0
TLS1_k127_581392_4 Amidohydrolase family K01443 GO:0003674,GO:0003824,GO:0005488,GO:0006040,GO:0006044,GO:0006046,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008270,GO:0008448,GO:0009056,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0016999,GO:0017001,GO:0017144,GO:0019213,GO:0019262,GO:0019752,GO:0022607,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046348,GO:0046395,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901575 3.5.1.25 0.000000000000000000000002205 104.0
TLS1_k127_581392_5 Domain of unknown function (DUF4326) - - - 0.000000000000000000001118 97.0
TLS1_k127_5818071_0 NADH flavin oxidoreductase NADH oxidase K21833 - - 7.697e-310 961.0
TLS1_k127_5818071_1 Adenylate K01768 - 4.6.1.1 1.613e-239 761.0
TLS1_k127_5818071_10 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 437.0
TLS1_k127_5818071_11 PFAM Mandelate racemase muconate lactonizing K19802 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 413.0
TLS1_k127_5818071_12 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 402.0
TLS1_k127_5818071_13 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003166 398.0
TLS1_k127_5818071_14 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 385.0
TLS1_k127_5818071_15 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 376.0
TLS1_k127_5818071_16 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 374.0
TLS1_k127_5818071_17 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008519 364.0
TLS1_k127_5818071_18 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 313.0
TLS1_k127_5818071_19 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005005 306.0
TLS1_k127_5818071_2 Branched-chain amino acid transport system / permease component K02057 - - 1.33e-201 632.0
TLS1_k127_5818071_20 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 291.0
TLS1_k127_5818071_21 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002571 279.0
TLS1_k127_5818071_22 KR domain K08261,K19548,K21620 - 1.1.1.16,1.1.1.385,1.1.99.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000001738 269.0
TLS1_k127_5818071_23 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004733 266.0
TLS1_k127_5818071_24 Apolipoprotein A1/A4/E domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001634 278.0
TLS1_k127_5818071_25 transporter component K07112 - - 0.0000000000000000000000000000000000000000000000001326 181.0
TLS1_k127_5818071_26 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.00000000000000000000000000000000000000000000006198 171.0
TLS1_k127_5818071_27 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000007729 163.0
TLS1_k127_5818071_28 Predicted membrane protein (DUF2214) K08983 - - 0.0000000000000000000000000000000000000002834 155.0
TLS1_k127_5818071_29 transporter component K07112 - - 0.00000000000000000000000000000006052 131.0
TLS1_k127_5818071_3 Periplasmic binding proteins and sugar binding domain of LacI family K02058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 544.0
TLS1_k127_5818071_30 Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) - - - 0.00000000002676 74.0
TLS1_k127_5818071_31 Histidine Phosphotransfer domain - - - 0.000000003744 63.0
TLS1_k127_5818071_32 YdjC-like protein - - - 0.000000005707 57.0
TLS1_k127_5818071_33 YdjC-like protein - - - 0.00007093 47.0
TLS1_k127_5818071_4 Arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 541.0
TLS1_k127_5818071_5 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 536.0
TLS1_k127_5818071_6 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 526.0
TLS1_k127_5818071_7 secondary active sulfate transmembrane transporter activity K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 508.0
TLS1_k127_5818071_8 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 468.0
TLS1_k127_5818071_9 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 451.0
TLS1_k127_582768_0 EamA-like transporter family - - - 0.00000000000000000000003213 115.0
TLS1_k127_582768_1 EamA-like transporter family - - - 0.00000000000000788 88.0
TLS1_k127_5875381_0 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 448.0
TLS1_k127_5875381_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 435.0
TLS1_k127_5875381_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 408.0
TLS1_k127_5875381_3 Murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 366.0
TLS1_k127_5875381_4 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000534 209.0
TLS1_k127_6074379_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0 1334.0
TLS1_k127_6074379_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 524.0
TLS1_k127_6074379_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 404.0
TLS1_k127_6092268_0 Belongs to the GcvT family K00302 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1 0.0 1211.0
TLS1_k127_6092268_1 Phosphate acyltransferases K05939 - 2.3.1.40,6.2.1.20 0.0 1205.0
TLS1_k127_6092268_10 4Fe-4S dicluster domain K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 5.901e-245 764.0
TLS1_k127_6092268_100 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 298.0
TLS1_k127_6092268_101 Redoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 286.0
TLS1_k127_6092268_102 Purine nucleoside K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001315 282.0
TLS1_k127_6092268_103 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001601 284.0
TLS1_k127_6092268_104 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000267 277.0
TLS1_k127_6092268_105 ABC-type tungstate transport system, periplasmic component K05773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001251 269.0
TLS1_k127_6092268_106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001335 265.0
TLS1_k127_6092268_107 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000005239 277.0
TLS1_k127_6092268_108 Cytochrome c, mono- and diheme variants - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002038 269.0
TLS1_k127_6092268_109 PFAM PfkB domain protein K00874 - 2.7.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000003531 257.0
TLS1_k127_6092268_11 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K12368,K15580 - - 6.474e-244 763.0
TLS1_k127_6092268_110 Asp Glu hydantoin racemase K01799 - 5.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000001802 246.0
TLS1_k127_6092268_111 histidine utilization repressor K05836 - - 0.00000000000000000000000000000000000000000000000000000000000000000001251 241.0
TLS1_k127_6092268_112 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000009784 247.0
TLS1_k127_6092268_113 Lysine exporter protein LysE YggA - - - 0.00000000000000000000000000000000000000000000000000000000000000004928 228.0
TLS1_k127_6092268_114 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000201 228.0
TLS1_k127_6092268_115 2-hydroxychromene-2-carboxylate isomerase K14584 - 5.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000006778 227.0
TLS1_k127_6092268_116 tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000002107 225.0
TLS1_k127_6092268_117 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000000000000001055 221.0
TLS1_k127_6092268_118 GntR family - - - 0.00000000000000000000000000000000000000000000000000000000000002601 222.0
TLS1_k127_6092268_119 Belongs to the ABC transporter superfamily K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000002576 220.0
TLS1_k127_6092268_12 ABC-type multidrug transport system ATPase and permease K06147,K18893 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - 2.089e-239 754.0
TLS1_k127_6092268_120 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000006986 203.0
TLS1_k127_6092268_121 Terminase-like family - - - 0.000000000000000000000000000000000000000000000000000002059 201.0
TLS1_k127_6092268_122 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000003102 186.0
TLS1_k127_6092268_123 Terminase RNaseH-like domain - - - 0.00000000000000000000000000000000000000000000001364 182.0
TLS1_k127_6092268_124 endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000001704 163.0
TLS1_k127_6092268_125 Inosine-uridine preferring nucleoside hydrolase K01239 - 3.2.2.1 0.00000000000000000000000000000000000000001697 166.0
TLS1_k127_6092268_126 MgtC family K07507 - - 0.00000000000000000000000000000000000001788 152.0
TLS1_k127_6092268_127 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530,K04764,K05787 - - 0.00000000000000000000000000000000000716 138.0
TLS1_k127_6092268_128 Lytic transglycolase K03642 - - 0.00000000000000000000000000000001714 130.0
TLS1_k127_6092268_129 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000000000000000000000001575 124.0
TLS1_k127_6092268_13 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family K00317 - 1.5.8.1,1.5.8.2 2.197e-238 756.0
TLS1_k127_6092268_130 Domain of unknown function (DUF1993) K09983 - - 0.000000000000000000000000000003836 128.0
TLS1_k127_6092268_131 Sarcosine oxidase, gamma subunit K00305,K22087 - 1.5.3.1,1.5.99.5 0.000000000000000000000000000008284 126.0
TLS1_k127_6092268_132 Sarcosine oxidase, delta subunit K00304,K22085 - 1.5.3.1,1.5.99.5 0.00000000000000000000000000001643 120.0
TLS1_k127_6092268_133 Protein of unknown function DUF126 K09128 - - 0.0000000000000000000000000004406 118.0
TLS1_k127_6092268_134 - - - - 0.000000000000000000000000001365 113.0
TLS1_k127_6092268_135 His Kinase A (phospho-acceptor) domain - - - 0.000000000000000000001012 106.0
TLS1_k127_6092268_136 Protein of unknown function (DUF3309) - - - 0.00000000000000000003913 91.0
TLS1_k127_6092268_137 Cytochrome C' - - - 0.0000000000000000002983 93.0
TLS1_k127_6092268_138 Ribosomal L32p protein family K02911 - - 0.0000000000000000003048 88.0
TLS1_k127_6092268_139 - - - - 0.0000000000000002251 84.0
TLS1_k127_6092268_14 Trimethylamine methyltransferase (MTTB) - - - 5.415e-234 733.0
TLS1_k127_6092268_140 - - - - 0.0000000000001562 77.0
TLS1_k127_6092268_141 Belongs to the aldehyde dehydrogenase family - - - 0.000001283 53.0
TLS1_k127_6092268_142 - - - - 0.0007204 44.0
TLS1_k127_6092268_15 Belongs to the GPI family K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 4.727e-233 732.0
TLS1_k127_6092268_16 Sarcosine oxidase subunit beta K00303,K22084 - 1.5.3.1,1.5.99.5 6.239e-232 722.0
TLS1_k127_6092268_17 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 3.568e-231 724.0
TLS1_k127_6092268_18 cytosine K01485 - 3.5.4.1 4.846e-219 685.0
TLS1_k127_6092268_19 glutamine synthetase K01915,K01949 - 6.3.1.2,6.3.4.12 6.004e-210 661.0
TLS1_k127_6092268_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.986e-304 940.0
TLS1_k127_6092268_20 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 9.409e-210 662.0
TLS1_k127_6092268_21 Belongs to the xylose isomerase family K01805 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 3.813e-204 643.0
TLS1_k127_6092268_22 ABC transporter K02056 - 3.6.3.17 4.126e-199 632.0
TLS1_k127_6092268_23 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 5.305e-197 627.0
TLS1_k127_6092268_24 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 612.0
TLS1_k127_6092268_25 Beta-Casp domain K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005408 615.0
TLS1_k127_6092268_26 alpha,alpha-trehalase activity K01194,K03931 GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 627.0
TLS1_k127_6092268_27 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 604.0
TLS1_k127_6092268_28 FGGY family of carbohydrate kinases, C-terminal domain K00854 - 2.7.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 597.0
TLS1_k127_6092268_29 homoserine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 587.0
TLS1_k127_6092268_3 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 7.037e-289 899.0
TLS1_k127_6092268_30 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009371 576.0
TLS1_k127_6092268_31 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K17722 - 1.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 571.0
TLS1_k127_6092268_32 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 576.0
TLS1_k127_6092268_33 Bacterial extracellular solute-binding protein K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 559.0
TLS1_k127_6092268_34 Histidine ammonia-lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 561.0
TLS1_k127_6092268_35 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 554.0
TLS1_k127_6092268_36 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005428 550.0
TLS1_k127_6092268_37 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 554.0
TLS1_k127_6092268_38 ABC transporter substrate-binding protein PnrA-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007453 544.0
TLS1_k127_6092268_39 ABC-type dipeptide oligopeptide nickel transport systems, permease components K12369 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 534.0
TLS1_k127_6092268_4 COG0747 ABC-type dipeptide transport system, periplasmic component K12368 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - 4.778e-279 865.0
TLS1_k127_6092268_40 Sulfate adenylyltransferase K00957 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 506.0
TLS1_k127_6092268_41 Trimethylamine methyltransferase (MTTB) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 519.0
TLS1_k127_6092268_42 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008369 515.0
TLS1_k127_6092268_43 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 509.0
TLS1_k127_6092268_44 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007435 513.0
TLS1_k127_6092268_45 Belongs to the ABC transporter superfamily K12371 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 496.0
TLS1_k127_6092268_46 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 501.0
TLS1_k127_6092268_47 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 493.0
TLS1_k127_6092268_48 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 493.0
TLS1_k127_6092268_49 Oxidative deamination of D-amino acids - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005533 492.0
TLS1_k127_6092268_5 NADH:flavin oxidoreductase / NADH oxidase family K00317 - 1.5.8.1,1.5.8.2 5.172e-275 861.0
TLS1_k127_6092268_50 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 483.0
TLS1_k127_6092268_51 Acetamidase/Formamidase family K01426,K01455 - 3.5.1.4,3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003744 481.0
TLS1_k127_6092268_52 Amidohydrolase family K05603 - 3.5.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 482.0
TLS1_k127_6092268_53 COG1228 Imidazolonepropionase and related amidohydrolases K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 473.0
TLS1_k127_6092268_54 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 465.0
TLS1_k127_6092268_55 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 466.0
TLS1_k127_6092268_56 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 468.0
TLS1_k127_6092268_57 Aminotransferase K00812,K12252 - 2.6.1.1,2.6.1.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009103 466.0
TLS1_k127_6092268_58 Fumarylacetoacetate (FAA) hydrolase family K16856 - 4.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 456.0
TLS1_k127_6092268_59 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K12253 - 4.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000803 470.0
TLS1_k127_6092268_6 Belongs to the glutamate synthase family K22083 - 2.1.1.21 9.124e-255 789.0
TLS1_k127_6092268_60 Aldo/keto reductase family K00064 - 1.1.1.122 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 456.0
TLS1_k127_6092268_61 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K12370 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 445.0
TLS1_k127_6092268_62 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 442.0
TLS1_k127_6092268_63 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 445.0
TLS1_k127_6092268_64 Belongs to the ABC transporter superfamily K12372 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 445.0
TLS1_k127_6092268_65 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008567 435.0
TLS1_k127_6092268_66 Belongs to the arginase family K01480,K18459 - 3.5.3.11,3.5.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008066 421.0
TLS1_k127_6092268_67 With GsiABD is involved in the transport of glutathione into the cell K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 404.0
TLS1_k127_6092268_68 ABC transporter K02049,K15555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 399.0
TLS1_k127_6092268_69 Spermidine putrescine-binding periplasmic protein K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 404.0
TLS1_k127_6092268_7 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 2.184e-248 777.0
TLS1_k127_6092268_70 Binding-protein-dependent transport system inner membrane component K11070 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 395.0
TLS1_k127_6092268_71 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 390.0
TLS1_k127_6092268_72 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009658 381.0
TLS1_k127_6092268_73 glutamine amidotransferase K22081 - 2.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 383.0
TLS1_k127_6092268_74 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 385.0
TLS1_k127_6092268_75 Xylose isomerase-like TIM barrel K18910 - 5.1.3.30,5.1.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 377.0
TLS1_k127_6092268_76 tRNA (Uracil-5-)-methyltransferase K00557,K03215 - 2.1.1.190,2.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 383.0
TLS1_k127_6092268_77 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005765 369.0
TLS1_k127_6092268_78 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 367.0
TLS1_k127_6092268_79 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 371.0
TLS1_k127_6092268_8 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685,K16846 - 4.2.1.7,4.4.1.24 7.201e-248 773.0
TLS1_k127_6092268_80 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 374.0
TLS1_k127_6092268_81 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 367.0
TLS1_k127_6092268_82 SIS domain K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 364.0
TLS1_k127_6092268_83 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 359.0
TLS1_k127_6092268_84 COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K10912 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 355.0
TLS1_k127_6092268_85 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 346.0
TLS1_k127_6092268_86 Fumarylacetoacetate (FAA) hydrolase family K16165 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 342.0
TLS1_k127_6092268_87 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019,K18335 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 340.0
TLS1_k127_6092268_88 Belongs to the ABC transporter superfamily K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 347.0
TLS1_k127_6092268_89 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 340.0
TLS1_k127_6092268_9 COG0004 Ammonia permease - - - 1.415e-246 767.0
TLS1_k127_6092268_90 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 344.0
TLS1_k127_6092268_91 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 336.0
TLS1_k127_6092268_92 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 341.0
TLS1_k127_6092268_93 pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 334.0
TLS1_k127_6092268_94 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 327.0
TLS1_k127_6092268_95 Binding-protein-dependent transport system inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 323.0
TLS1_k127_6092268_96 GXGXG motif K22082 - 2.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 315.0
TLS1_k127_6092268_97 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 304.0
TLS1_k127_6092268_98 Uracil phosphoribosyltransferase K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002184 301.0
TLS1_k127_6092268_99 Asp Glu Hydantoin racemase family protein K01799 - 5.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 305.0
TLS1_k127_6122633_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 537.0
TLS1_k127_6122633_1 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 505.0
TLS1_k127_6122633_2 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000002682 218.0
TLS1_k127_6122633_3 Predicted secreted protein (DUF2259) - - - 0.0000000000000000000000000000000000000006804 157.0
TLS1_k127_6122633_4 - - - - 0.0000000000000000000000000000000008696 134.0
TLS1_k127_6122633_5 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000000000003381 131.0
TLS1_k127_613012_0 ABC-type proline glycine betaine transport system permease component K02001 - - 1.54e-301 936.0
TLS1_k127_613012_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.337e-251 785.0
TLS1_k127_613012_10 Glycosyl transferase, family 2 K07011 - - 0.00000000000002026 78.0
TLS1_k127_613012_2 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 562.0
TLS1_k127_613012_3 ABC transporter K02000 - 3.6.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 497.0
TLS1_k127_613012_4 Amidinotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 383.0
TLS1_k127_613012_5 Esterase PHB depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 328.0
TLS1_k127_613012_6 Phenazine biosynthesis protein PhzF K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 300.0
TLS1_k127_613012_7 copG family - - - 0.000000000000000000000000000000000000000000000000006587 184.0
TLS1_k127_613012_8 -acetyltransferase - - - 0.00000000000000000000000000000000001737 143.0
TLS1_k127_6170172_0 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 333.0
TLS1_k127_6170172_1 Acyl-CoA dehydrogenase, N-terminal domain K00253 - 1.3.8.4 0.0000000000000000000000000000000000000000000000000000000000000000000001373 239.0
TLS1_k127_6170172_2 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000007067 234.0
TLS1_k127_6170172_3 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000002477 220.0
TLS1_k127_619586_0 Phytoene dehydrogenase - - - 5.587e-244 764.0
TLS1_k127_619586_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003299 368.0
TLS1_k127_619586_2 glutamine amidotransferase K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 317.0
TLS1_k127_619586_3 Aldehyde dehydrogenase family K00137 - 1.2.1.19 0.00000000000000000000000000000000000000000000000000000000000002041 215.0
TLS1_k127_619586_4 SET domain K07117 - - 0.000000000000000000000000000000000001189 143.0
TLS1_k127_6230290_0 Heat shock 70 kDa protein - - - 3.035e-316 977.0
TLS1_k127_6230290_1 ABC transporter K15738 - - 5.797e-291 902.0
TLS1_k127_6230290_10 Iron-sulfur cluster-binding domain K06139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 472.0
TLS1_k127_6230290_11 Putrescine transport system permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 435.0
TLS1_k127_6230290_12 PFAM Amidohydrolase 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 426.0
TLS1_k127_6230290_13 ABC-type multidrug transport system ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 412.0
TLS1_k127_6230290_14 DnaJ C terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 390.0
TLS1_k127_6230290_15 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137,K06138 - 1.3.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 355.0
TLS1_k127_6230290_16 Putative DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 355.0
TLS1_k127_6230290_17 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005983 363.0
TLS1_k127_6230290_18 Transcriptional regulator K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 342.0
TLS1_k127_6230290_19 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 323.0
TLS1_k127_6230290_2 glucose sorbosone - - - 2.946e-209 657.0
TLS1_k127_6230290_20 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 314.0
TLS1_k127_6230290_21 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005011 283.0
TLS1_k127_6230290_22 Predicted membrane protein (DUF2231) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007484 266.0
TLS1_k127_6230290_23 Protein of unknown function (DUF1109) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002976 264.0
TLS1_k127_6230290_24 secretion protein K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001149 270.0
TLS1_k127_6230290_25 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004267 257.0
TLS1_k127_6230290_26 PFAM DoxX family protein K15977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006632 250.0
TLS1_k127_6230290_27 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002519 231.0
TLS1_k127_6230290_28 Short repeat of unknown function (DUF308) - - - 0.0000000000000000000000000000000000000000000000000001052 193.0
TLS1_k127_6230290_29 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000002053 192.0
TLS1_k127_6230290_3 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 603.0
TLS1_k127_6230290_30 Predicted integral membrane protein (DUF2282) - - - 0.00000000000000000000000000000000000000000000001063 173.0
TLS1_k127_6230290_31 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000002274 178.0
TLS1_k127_6230290_32 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000000001818 149.0
TLS1_k127_6230290_33 EamA-like transporter family - - - 0.0000000000000000000000000000000000002464 154.0
TLS1_k127_6230290_34 cytochrome - - - 0.00000000000000000000000000000000005762 136.0
TLS1_k127_6230290_35 Transcriptional activator HlyU - - - 0.0000000000000000000000000000000003531 134.0
TLS1_k127_6230290_36 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000003262 129.0
TLS1_k127_6230290_37 peptidyl-tyrosine modification K06138 - - 0.0000000000000000126 91.0
TLS1_k127_6230290_38 MerR HTH family regulatory protein K18997 - - 0.00000000000000009178 84.0
TLS1_k127_6230290_39 Domain of unknown function (DUF1127) - - - 0.0005221 45.0
TLS1_k127_6230290_4 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 518.0
TLS1_k127_6230290_5 Belongs to the UPF0276 family K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 509.0
TLS1_k127_6230290_6 DNA polymerase III, epsilon subunit K02342,K07182 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 518.0
TLS1_k127_6230290_7 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003497 501.0
TLS1_k127_6230290_8 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 504.0
TLS1_k127_6230290_9 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 476.0
TLS1_k127_6241572_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 4.338e-197 626.0
TLS1_k127_6241572_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006053 584.0
TLS1_k127_6241572_2 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 363.0
TLS1_k127_6286315_0 D-galactarate dehydratase Altronate hydrolase K01685 - 4.2.1.7 5.596e-196 615.0
TLS1_k127_6286315_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000001533 210.0
TLS1_k127_6297055_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.265e-215 676.0
TLS1_k127_6297055_1 MgsA AAA+ ATPase C terminal K07478 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 8.115e-198 624.0
TLS1_k127_6297055_10 50S ribosomal protein L4 K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 293.0
TLS1_k127_6297055_11 ribosomal L5P family C-terminus K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 289.0
TLS1_k127_6297055_12 Ribosomal protein L6 K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001252 265.0
TLS1_k127_6297055_13 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000000000000000001471 237.0
TLS1_k127_6297055_14 Ribosomal protein L14p/L23e K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000003177 221.0
TLS1_k127_6297055_15 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001563 221.0
TLS1_k127_6297055_16 RNA pseudouridylate synthase K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000002595 231.0
TLS1_k127_6297055_17 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000107 208.0
TLS1_k127_6297055_18 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001264 206.0
TLS1_k127_6297055_19 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000001576 197.0
TLS1_k127_6297055_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 566.0
TLS1_k127_6297055_20 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000005863 190.0
TLS1_k127_6297055_21 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000008089 186.0
TLS1_k127_6297055_22 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000002837 175.0
TLS1_k127_6297055_23 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000005858 162.0
TLS1_k127_6297055_24 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000000002643 154.0
TLS1_k127_6297055_25 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000001099 153.0
TLS1_k127_6297055_26 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000001257 145.0
TLS1_k127_6297055_27 Transcriptional regulator - - - 0.000000000000000000000000000000000007491 140.0
TLS1_k127_6297055_28 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001363 138.0
TLS1_k127_6297055_29 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000000000001788 139.0
TLS1_k127_6297055_3 Trypsin K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 494.0
TLS1_k127_6297055_30 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000006039 125.0
TLS1_k127_6297055_31 Ribosomal protein L30p/L7e K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000009118 95.0
TLS1_k127_6297055_32 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000008298 87.0
TLS1_k127_6297055_33 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000396 80.0
TLS1_k127_6297055_4 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 427.0
TLS1_k127_6297055_5 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 384.0
TLS1_k127_6297055_6 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 364.0
TLS1_k127_6297055_7 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008102 334.0
TLS1_k127_6297055_8 Belongs to the universal ribosomal protein uS5 family K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009467 293.0
TLS1_k127_6297055_9 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 293.0
TLS1_k127_6334718_0 Extracellular solute-binding protein K17321 - - 0.0 1018.0
TLS1_k127_6334718_1 Acetyl-coenzyme A synthetase N-terminus K01895,K01908 GO:0003674,GO:0003824,GO:0003987,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017144,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046950,GO:0046951,GO:0070013,GO:0071704,GO:1901568,GO:1901570,GO:1901576,GO:1902224 6.2.1.1,6.2.1.17 1.501e-317 981.0
TLS1_k127_6334718_10 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 1.77e-253 795.0
TLS1_k127_6334718_100 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000001096 230.0
TLS1_k127_6334718_101 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000003255 229.0
TLS1_k127_6334718_102 PFAM Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000001453 228.0
TLS1_k127_6334718_103 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000003402 226.0
TLS1_k127_6334718_104 AIR carboxylase K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000005613 225.0
TLS1_k127_6334718_105 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000003834 225.0
TLS1_k127_6334718_106 COG0671 Membrane-associated phospholipid phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000006341 231.0
TLS1_k127_6334718_107 - - - - 0.00000000000000000000000000000000000000000000000000000000000002092 220.0
TLS1_k127_6334718_108 L,D-transpeptidase catalytic domain K16291 - - 0.00000000000000000000000000000000000000000000000000000000000007849 221.0
TLS1_k127_6334718_109 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000003268 230.0
TLS1_k127_6334718_11 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 2.405e-237 745.0
TLS1_k127_6334718_110 Pyroglutamyl peptidase K01304 - 3.4.19.3 0.000000000000000000000000000000000000000000000000000000000002203 218.0
TLS1_k127_6334718_111 Dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001838 209.0
TLS1_k127_6334718_112 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000000000000009409 220.0
TLS1_k127_6334718_113 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000005752 201.0
TLS1_k127_6334718_114 Protein of unknown function (DUF1036) - - - 0.0000000000000000000000000000000000000000000000000000006075 195.0
TLS1_k127_6334718_115 - K06039,K07092 - - 0.000000000000000000000000000000000000000000000000000193 187.0
TLS1_k127_6334718_116 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000001667 185.0
TLS1_k127_6334718_117 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000001388 185.0
TLS1_k127_6334718_118 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000000000000000000002464 175.0
TLS1_k127_6334718_119 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating K05710,K14578,K18248 - - 0.00000000000000000000000000000000000000000000001674 173.0
TLS1_k127_6334718_12 Aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 6.368e-233 730.0
TLS1_k127_6334718_120 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000000000000000000000000002095 171.0
TLS1_k127_6334718_121 Protein of unknown function (DUF1465) K13592 - - 0.000000000000000000000000000000000000000001761 163.0
TLS1_k127_6334718_122 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000008289 162.0
TLS1_k127_6334718_123 NAD NADP transhydrogenase alpha subunit K00324 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.000000000000000000000000000000000000001509 150.0
TLS1_k127_6334718_124 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000000000000000006421 143.0
TLS1_k127_6334718_125 - - - - 0.00000000000000000000000000000000000008765 145.0
TLS1_k127_6334718_126 - - - - 0.0000000000000000000000000000000000002232 145.0
TLS1_k127_6334718_127 small integral membrane protein - - - 0.0000000000000000000000000000000001403 134.0
TLS1_k127_6334718_128 with the TIM-barrel fold - - - 0.000000000000000000000000000000000312 144.0
TLS1_k127_6334718_129 50S ribosomal protein L31 K02909 - - 0.00000000000000000000000000000000369 128.0
TLS1_k127_6334718_13 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 1.972e-212 668.0
TLS1_k127_6334718_130 Protein of unknown function (DUF1244) K09948 - - 0.000000000000000000000000000000004978 135.0
TLS1_k127_6334718_131 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000002552 128.0
TLS1_k127_6334718_132 Transcriptional regulator - - - 0.0000000000000000000000000000003174 126.0
TLS1_k127_6334718_133 Uncharacterized protein conserved in bacteria (DUF2312) - - - 0.00000000000000000000000000119 114.0
TLS1_k127_6334718_134 - - - - 0.000000000000000000000000002506 112.0
TLS1_k127_6334718_135 polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.00000000000000000000000002878 113.0
TLS1_k127_6334718_136 - - - - 0.00000000000000000000000008732 110.0
TLS1_k127_6334718_137 - - - - 0.000000000000000000000001357 107.0
TLS1_k127_6334718_138 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000003952 98.0
TLS1_k127_6334718_139 - - - - 0.0000000000000000001353 91.0
TLS1_k127_6334718_14 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 7.414e-211 668.0
TLS1_k127_6334718_140 Dodecin K09165 - - 0.0000000000000000003202 88.0
TLS1_k127_6334718_141 - - - - 0.00000000000000001093 85.0
TLS1_k127_6334718_142 - - - - 0.00000000000000002782 83.0
TLS1_k127_6334718_143 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000005855 86.0
TLS1_k127_6334718_144 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000001424 73.0
TLS1_k127_6334718_145 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000001845 74.0
TLS1_k127_6334718_146 small protein containing a coiled-coil domain - - - 0.0000000000005245 71.0
TLS1_k127_6334718_147 Protein of unknown function (DUF465) - - - 0.000000000001938 68.0
TLS1_k127_6334718_148 - - - - 0.000000000004776 73.0
TLS1_k127_6334718_149 Cytochrome c - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000003586 66.0
TLS1_k127_6334718_15 acyl-CoA dehydrogenase K09456 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 3.411e-209 663.0
TLS1_k127_6334718_150 Protein of unknown function (DUF1192) - - - 0.0000000157 58.0
TLS1_k127_6334718_151 - - - - 0.00000001613 60.0
TLS1_k127_6334718_153 - - - - 0.00002662 48.0
TLS1_k127_6334718_155 Bacterial aa3 type cytochrome c oxidase subunit IV - - - 0.00005842 50.0
TLS1_k127_6334718_156 reductase K19265 - - 0.0001945 46.0
TLS1_k127_6334718_157 DHH family K07462 - - 0.0003942 52.0
TLS1_k127_6334718_158 NnrS protein K07234 - - 0.0005997 43.0
TLS1_k127_6334718_16 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.733e-204 647.0
TLS1_k127_6334718_17 ABC transporter transmembrane region K06147 - - 7.943e-203 648.0
TLS1_k127_6334718_18 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 9.754e-201 636.0
TLS1_k127_6334718_19 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 1.765e-199 631.0
TLS1_k127_6334718_2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 2.353e-289 907.0
TLS1_k127_6334718_20 Adenylate cyclase - - - 3.764e-197 625.0
TLS1_k127_6334718_21 ABC1 family - - - 1.505e-196 624.0
TLS1_k127_6334718_22 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 610.0
TLS1_k127_6334718_23 esterase lipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008224 637.0
TLS1_k127_6334718_24 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 575.0
TLS1_k127_6334718_25 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 613.0
TLS1_k127_6334718_26 oxidoreductase' - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000602 572.0
TLS1_k127_6334718_27 COG0687 Spermidine putrescine-binding periplasmic protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 562.0
TLS1_k127_6334718_28 Belongs to the thiolase family K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 550.0
TLS1_k127_6334718_29 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 544.0
TLS1_k127_6334718_3 converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA - - - 3.838e-284 893.0
TLS1_k127_6334718_30 Acetyl-coenzyme A transporter 1 K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 536.0
TLS1_k127_6334718_31 Extracellular solute-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 530.0
TLS1_k127_6334718_32 Required for the activity of the bacterial periplasmic transport system of putrescine K11069 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 527.0
TLS1_k127_6334718_33 Uncharacterized protein conserved in bacteria (DUF2334) K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 518.0
TLS1_k127_6334718_34 Berberine and berberine like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 521.0
TLS1_k127_6334718_35 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 517.0
TLS1_k127_6334718_36 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 502.0
TLS1_k127_6334718_37 Belongs to the ABC transporter superfamily K17325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 497.0
TLS1_k127_6334718_38 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007266 501.0
TLS1_k127_6334718_39 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 484.0
TLS1_k127_6334718_4 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 1.325e-279 878.0
TLS1_k127_6334718_40 COG1175 ABC-type sugar transport systems permease components K17322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 481.0
TLS1_k127_6334718_41 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 479.0
TLS1_k127_6334718_42 ABC-type sugar transport system, permease component K17323 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 463.0
TLS1_k127_6334718_43 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 466.0
TLS1_k127_6334718_44 PFAM peptidase S1 and S6 chymotrypsin Hap K08070 - 1.3.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 452.0
TLS1_k127_6334718_45 Ring hydroxylating alpha subunit (catalytic domain) K00499 - 1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008384 449.0
TLS1_k127_6334718_46 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 446.0
TLS1_k127_6334718_47 Arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 447.0
TLS1_k127_6334718_48 Belongs to the ABC transporter superfamily K17324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 445.0
TLS1_k127_6334718_49 TOBE domain K02052,K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007444 445.0
TLS1_k127_6334718_5 COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K02182 - 6.2.1.48 1.616e-279 867.0
TLS1_k127_6334718_50 Alanine dehydrogenase/PNT, N-terminal domain K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 438.0
TLS1_k127_6334718_51 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 432.0
TLS1_k127_6334718_52 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 419.0
TLS1_k127_6334718_53 TOBE domain K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 421.0
TLS1_k127_6334718_54 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 416.0
TLS1_k127_6334718_55 acid transport K02028,K09972 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007394 413.0
TLS1_k127_6334718_56 N-terminal TM domain of oligopeptide transport permease C K02034,K13891 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 413.0
TLS1_k127_6334718_57 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006275 413.0
TLS1_k127_6334718_58 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 416.0
TLS1_k127_6334718_59 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 413.0
TLS1_k127_6334718_6 Oligoendopeptidase F K08602 - - 2.595e-279 869.0
TLS1_k127_6334718_60 ABC transporter K02031,K15587 - 3.6.3.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 392.0
TLS1_k127_6334718_61 Transcriptional regulator K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 386.0
TLS1_k127_6334718_62 ABC-type spermidine putrescine transport system, permease component I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 380.0
TLS1_k127_6334718_63 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0008874,GO:0008875,GO:0016491,GO:0016614,GO:0016616,GO:0036094,GO:0042802,GO:0042803,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 376.0
TLS1_k127_6334718_64 OmpA family K02557 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 377.0
TLS1_k127_6334718_65 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 365.0
TLS1_k127_6334718_66 ABC transporter K02052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 366.0
TLS1_k127_6334718_67 Cobalamin synthesis protein cobW C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 364.0
TLS1_k127_6334718_68 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 357.0
TLS1_k127_6334718_69 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008941 359.0
TLS1_k127_6334718_7 PFAM glycoside hydrolase 15-related - - - 7.904e-270 841.0
TLS1_k127_6334718_70 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 373.0
TLS1_k127_6334718_71 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 368.0
TLS1_k127_6334718_72 EamA-like transporter family K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 362.0
TLS1_k127_6334718_73 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 353.0
TLS1_k127_6334718_74 ABC-type spermidine putrescine transport system, permease component I K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 352.0
TLS1_k127_6334718_75 Family of unknown function (DUF1028) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 345.0
TLS1_k127_6334718_76 protein conserved in bacteria K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 364.0
TLS1_k127_6334718_77 ABC-type spermidine putrescine transport system, permease component II K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005035 333.0
TLS1_k127_6334718_78 PBP superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 330.0
TLS1_k127_6334718_79 ATPases associated with a variety of cellular activities K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 328.0
TLS1_k127_6334718_8 X-Pro dipeptidyl-peptidase (S15 family) K06978 - - 1.629e-264 830.0
TLS1_k127_6334718_80 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 345.0
TLS1_k127_6334718_81 MotA TolQ ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 323.0
TLS1_k127_6334718_82 Belongs to the UPF0271 (lamB) family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 318.0
TLS1_k127_6334718_83 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 314.0
TLS1_k127_6334718_84 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 322.0
TLS1_k127_6334718_85 Belongs to the ABC transporter superfamily K02031,K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 322.0
TLS1_k127_6334718_86 Protein of unknown function (DUF1013) K09987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 311.0
TLS1_k127_6334718_87 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K18009 - 1.1.1.304,1.1.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 310.0
TLS1_k127_6334718_88 Binding-protein-dependent transport system inner membrane component K02053,K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006176 307.0
TLS1_k127_6334718_89 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 297.0
TLS1_k127_6334718_9 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 1.106e-262 820.0
TLS1_k127_6334718_90 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001574 278.0
TLS1_k127_6334718_91 allophanate hydrolase subunit 2 K01457 - 3.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002603 281.0
TLS1_k127_6334718_92 beta-N-acetylhexosaminidase K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006893 279.0
TLS1_k127_6334718_93 Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001666 269.0
TLS1_k127_6334718_94 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003864 272.0
TLS1_k127_6334718_95 HWE histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000888 261.0
TLS1_k127_6334718_96 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001248 248.0
TLS1_k127_6334718_97 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000004097 240.0
TLS1_k127_6334718_98 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000007899 241.0
TLS1_k127_6334718_99 Allophanate hydrolase subunit 1 K01457,K06351 - 3.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000167 233.0
TLS1_k127_6359828_0 4TM region of DNA translocase FtsK/SpoIIIE K03466 - - 1.103e-261 831.0
TLS1_k127_6359828_1 FAD binding domain K03185 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 368.0
TLS1_k127_6359828_2 Thioesterase-like superfamily K10805 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 341.0
TLS1_k127_6359828_3 ATP-dependent protease La (LON) substrate-binding domain K01338,K07157 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000003108 235.0
TLS1_k127_6359828_4 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000000000002981 168.0
TLS1_k127_6359828_5 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000001104 156.0
TLS1_k127_6359828_6 Tetratricopeptide repeat K03671,K05838 - - 0.00000000000000000000000000000000009968 135.0
TLS1_k127_6359828_7 Trm112p-like protein K09791 - - 0.0000000000000000005736 89.0
TLS1_k127_6454514_0 FAD dependent oxidoreductase central domain - - - 0.0 1146.0
TLS1_k127_6454514_1 Belongs to the ABC transporter superfamily K02031,K02032,K13896 - - 1.057e-317 986.0
TLS1_k127_6454514_10 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 291.0
TLS1_k127_6454514_11 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009237 262.0
TLS1_k127_6454514_12 Dimethlysulfonioproprionate lyase - - - 0.00000000000000000001949 100.0
TLS1_k127_6454514_13 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.0000000000582 64.0
TLS1_k127_6454514_14 - - - - 0.0000000001254 65.0
TLS1_k127_6454514_2 NADH:flavin oxidoreductase / NADH oxidase family - - - 6.157e-268 842.0
TLS1_k127_6454514_3 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 566.0
TLS1_k127_6454514_4 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 548.0
TLS1_k127_6454514_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 490.0
TLS1_k127_6454514_6 DNA restriction-modification system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 475.0
TLS1_k127_6454514_7 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 420.0
TLS1_k127_6454514_8 PFAM binding-protein-dependent transport systems inner membrane component K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 365.0
TLS1_k127_6454514_9 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 343.0
TLS1_k127_6520875_0 Glutamine amidotransferase domain K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 2.073e-245 766.0
TLS1_k127_6520875_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 581.0
TLS1_k127_6520875_10 COG0671 Membrane-associated phospholipid phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000004469 231.0
TLS1_k127_6520875_11 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000006749 197.0
TLS1_k127_6520875_12 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000004079 185.0
TLS1_k127_6520875_13 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000000000000009396 173.0
TLS1_k127_6520875_14 Colicin V production protein K03558 - - 0.000000000000000000000000000000000000000001977 164.0
TLS1_k127_6520875_15 NnrU protein - - - 0.000000000000000000000000000000000000000004305 161.0
TLS1_k127_6520875_16 membrane - - - 0.000000000000000000000000000000000000000179 162.0
TLS1_k127_6520875_17 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000002095 138.0
TLS1_k127_6520875_18 2-oxopent-4-enoate hydratase activity - - - 0.000000000000000000000000000000000007563 146.0
TLS1_k127_6520875_19 Involved in chromosome partitioning - - - 0.00000000000000001048 93.0
TLS1_k127_6520875_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 574.0
TLS1_k127_6520875_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 407.0
TLS1_k127_6520875_4 PQQ-like domain K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 358.0
TLS1_k127_6520875_5 KR domain - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 305.0
TLS1_k127_6520875_6 Multi-copper - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 305.0
TLS1_k127_6520875_7 Involved in chromosome partitioning - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004052 284.0
TLS1_k127_6520875_8 Putative vitamin uptake transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002437 245.0
TLS1_k127_6520875_9 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000174 220.0
TLS1_k127_6522425_0 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001146 270.0
TLS1_k127_6522425_1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000003454 239.0
TLS1_k127_6522425_2 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000001334 237.0
TLS1_k127_6522425_3 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000003548 197.0
TLS1_k127_6567042_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1400.0
TLS1_k127_6567042_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0 1266.0
TLS1_k127_6567042_10 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 499.0
TLS1_k127_6567042_11 Choline ABC transporter periplasmic binding protein K02002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 464.0
TLS1_k127_6567042_12 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005115 459.0
TLS1_k127_6567042_13 COG4175 ABC-type proline glycine betaine transport system ATPase component K02000 GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 443.0
TLS1_k127_6567042_14 ABC transporter K02001 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006836,GO:0008150,GO:0015695,GO:0015696,GO:0015871,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 426.0
TLS1_k127_6567042_15 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 368.0
TLS1_k127_6567042_16 Amino-transferase class IV K00824 - 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 345.0
TLS1_k127_6567042_17 Nitrile hydratase K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 325.0
TLS1_k127_6567042_18 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000602 294.0
TLS1_k127_6567042_19 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000101 278.0
TLS1_k127_6567042_2 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 2.288e-273 849.0
TLS1_k127_6567042_20 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004017 273.0
TLS1_k127_6567042_21 KR domain K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000007561 268.0
TLS1_k127_6567042_22 Belongs to the NiCoT transporter (TC 2.A.52) family K08970 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001032 281.0
TLS1_k127_6567042_23 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009445 260.0
TLS1_k127_6567042_24 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001749 258.0
TLS1_k127_6567042_25 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000455 250.0
TLS1_k127_6567042_26 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.0000000000000000000000000000000000000000000000000000000000000000000001313 248.0
TLS1_k127_6567042_27 Uncharacterized protein family, UPF0114 - - - 0.000000000000000000000000000000000000000000000000000000000001397 214.0
TLS1_k127_6567042_28 proteolysis - - - 0.0000000000000000000000000000000000000000001951 170.0
TLS1_k127_6567042_29 Histidine kinase - - - 0.000000000000000000000000000000004809 132.0
TLS1_k127_6567042_3 Amino acid permease K03294,K16238 - - 8.941e-233 728.0
TLS1_k127_6567042_30 Nitrile hydratase - - - 0.000000000000000000000000000007627 123.0
TLS1_k127_6567042_4 glutamine synthetase K01915 - 6.3.1.2 3.311e-227 711.0
TLS1_k127_6567042_5 Aldehyde dehydrogenase family - - - 2.499e-215 678.0
TLS1_k127_6567042_6 Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 587.0
TLS1_k127_6567042_7 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 560.0
TLS1_k127_6567042_8 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005745 552.0
TLS1_k127_6567042_9 Iron-containing alcohol dehydrogenase K00001,K00043 - 1.1.1.1,1.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 500.0
TLS1_k127_6601705_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 468.0
TLS1_k127_6601705_1 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004707 343.0
TLS1_k127_6601705_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000009053 155.0
TLS1_k127_6601705_3 CsbD-like - - - 0.00000000001892 65.0
TLS1_k127_6601705_4 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000002935 51.0
TLS1_k127_66041_0 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 394.0
TLS1_k127_6657851_0 Glutamate-ammonia ligase adenylyltransferase K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 8.945e-297 938.0
TLS1_k127_6657851_1 Domain of unknown function (DUF3458_C) ARM repeats K01256 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 9.497e-261 820.0
TLS1_k127_6657851_10 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - 0.00000000000000000000000000000000000000000000000001132 183.0
TLS1_k127_6657851_11 subunit of a heme lyase K02200 - - 0.00000000000000000000000000000000000000000007003 168.0
TLS1_k127_6657851_12 Sarcosine oxidase K00304 - 1.5.3.1 0.0000000000000000000000000001504 118.0
TLS1_k127_6657851_13 EF-hand, calcium binding motif - - - 0.0000002308 58.0
TLS1_k127_6657851_2 Cytochrome c-type biogenesis protein K02198 - - 3.319e-257 809.0
TLS1_k127_6657851_3 PAS fold K07716 - 2.7.13.3 3.993e-206 665.0
TLS1_k127_6657851_4 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 578.0
TLS1_k127_6657851_5 Trypsin K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 458.0
TLS1_k127_6657851_6 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 437.0
TLS1_k127_6657851_7 Transcriptional regulatory protein, C terminal K02483 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 332.0
TLS1_k127_6657851_8 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003523 259.0
TLS1_k127_6657851_9 Belongs to the GcvT family K00302,K22086 - 1.5.3.1,1.5.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000004526 249.0
TLS1_k127_6810662_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1019.0
TLS1_k127_6810662_1 Belongs to the GcvT family K00315 - 1.5.8.4 5.03e-279 880.0
TLS1_k127_6810662_2 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 456.0
TLS1_k127_6810662_3 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000003545 201.0
TLS1_k127_6810662_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000008899 171.0
TLS1_k127_6810662_5 MarR family - - - 0.000000000000000000000000000000000000002229 153.0
TLS1_k127_6810662_6 Transcriptional regulator - - - 0.000000000000000000000000000000000007866 138.0
TLS1_k127_6810662_7 Outer membrane protease - - - 0.000000000000000000000000000000003018 136.0
TLS1_k127_6810662_8 OmpA family - - - 0.0000000000000000000000000000008397 141.0
TLS1_k127_6817328_0 DEAD/H associated K03724 - - 0.0 1102.0
TLS1_k127_6817328_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 541.0
TLS1_k127_6817328_2 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 494.0
TLS1_k127_6817328_3 MatE K03327 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004424 400.0
TLS1_k127_6817328_4 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 383.0
TLS1_k127_6817328_5 Glycosyl transferase family group 2 K20327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 302.0
TLS1_k127_6817328_6 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000005199 219.0
TLS1_k127_6862794_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 4.277e-286 890.0
TLS1_k127_6862794_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.003e-271 842.0
TLS1_k127_6862794_10 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001778 245.0
TLS1_k127_6862794_11 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000004652 226.0
TLS1_k127_6862794_12 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000000000000000000001465 207.0
TLS1_k127_6862794_13 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000000000003863 186.0
TLS1_k127_6862794_14 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000001255 166.0
TLS1_k127_6862794_15 HAD-hyrolase-like - - - 0.00000000000000000000000000000000000000002849 161.0
TLS1_k127_6862794_16 Ribosomal silencing factor during starvation K09710 - - 0.00000000000000000000000000000000000003079 147.0
TLS1_k127_6862794_17 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000001315 145.0
TLS1_k127_6862794_18 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000642 108.0
TLS1_k127_6862794_19 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.0000000000004933 70.0
TLS1_k127_6862794_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 8.299e-242 767.0
TLS1_k127_6862794_20 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000005707 57.0
TLS1_k127_6862794_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 540.0
TLS1_k127_6862794_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 503.0
TLS1_k127_6862794_5 GTP1/OBG K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 483.0
TLS1_k127_6862794_6 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 454.0
TLS1_k127_6862794_7 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 406.0
TLS1_k127_6862794_8 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008956 327.0
TLS1_k127_6862794_9 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001078 267.0
TLS1_k127_68708_0 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 476.0
TLS1_k127_68708_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000958 443.0
TLS1_k127_6918095_0 GTP-binding protein K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 5.472e-307 953.0
TLS1_k127_6918095_1 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 2.19e-283 884.0
TLS1_k127_6918095_10 Domain of unknown function DUF21 K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 459.0
TLS1_k127_6918095_11 Periplasmic binding protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 445.0
TLS1_k127_6918095_12 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008663 446.0
TLS1_k127_6918095_13 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007971 426.0
TLS1_k127_6918095_14 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 426.0
TLS1_k127_6918095_15 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 389.0
TLS1_k127_6918095_16 Sugar ABC transporter ATP-binding protein K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000183 361.0
TLS1_k127_6918095_17 Dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 357.0
TLS1_k127_6918095_18 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 349.0
TLS1_k127_6918095_19 Xylose isomerase-like TIM barrel K03335 - 4.2.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007998 348.0
TLS1_k127_6918095_2 Thiamine pyrophosphate enzyme, central domain K03336 - 3.7.1.22 5.029e-269 840.0
TLS1_k127_6918095_20 PFAM HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 341.0
TLS1_k127_6918095_21 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 308.0
TLS1_k127_6918095_22 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003202 297.0
TLS1_k127_6918095_23 DedA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001298 251.0
TLS1_k127_6918095_24 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000005697 228.0
TLS1_k127_6918095_25 endonuclease III K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000001349 192.0
TLS1_k127_6918095_26 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000001186 193.0
TLS1_k127_6918095_27 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000005093 166.0
TLS1_k127_6918095_28 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.0000000000000000000000000000000000000000002498 162.0
TLS1_k127_6918095_29 invasion associated locus B - - - 0.0000000000000000000000000000000000000000003624 164.0
TLS1_k127_6918095_3 reductase K00001,K14446 - 1.1.1.1,1.3.1.85 1.454e-235 733.0
TLS1_k127_6918095_30 Disulfide bond formation protein DsbB K03611 - - 0.0000000000000000000000000000000000000001751 154.0
TLS1_k127_6918095_31 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000003201 136.0
TLS1_k127_6918095_32 - - - - 0.000000000000000000000000001524 116.0
TLS1_k127_6918095_33 YGGT family K02221 - - 0.00000000000000000000001133 105.0
TLS1_k127_6918095_34 DUF167 K09131 - - 0.00000000000000008444 86.0
TLS1_k127_6918095_35 - - - - 0.000000000000001612 84.0
TLS1_k127_6918095_36 PFAM Hypoxia induced protein conserved region - - - 0.0000000000009565 69.0
TLS1_k127_6918095_37 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000001514 58.0
TLS1_k127_6918095_4 Acyl-CoA dehydrogenase, C-terminal domain K14448 - 1.3.8.12 3.22e-232 730.0
TLS1_k127_6918095_5 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 6.596e-224 698.0
TLS1_k127_6918095_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 552.0
TLS1_k127_6918095_7 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 564.0
TLS1_k127_6918095_8 GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 545.0
TLS1_k127_6918095_9 ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 477.0
TLS1_k127_7091347_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0 1221.0
TLS1_k127_7091347_1 ATPases associated with a variety of cellular activities K02003,K05685 - - 3.684e-264 833.0
TLS1_k127_7091347_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 421.0
TLS1_k127_7133410_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.029e-320 989.0
TLS1_k127_7133410_1 B3/4 domain K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 7.5e-308 966.0
TLS1_k127_7133410_10 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.000000000000000000000000000000000000000000000000001586 184.0
TLS1_k127_7133410_11 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000004411 102.0
TLS1_k127_7133410_12 gluconolactonase K01053 - 3.1.1.17 0.0000000000000000000008936 104.0
TLS1_k127_7133410_13 Recombinase zinc beta ribbon domain K06400 - - 0.00000000003951 64.0
TLS1_k127_7133410_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0008150,GO:0008152,GO:0015945,GO:0034308,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:1901615 1.1.1.1,1.1.1.284 6.461e-203 635.0
TLS1_k127_7133410_3 tRNA synthetases class II core domain (F) K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 518.0
TLS1_k127_7133410_4 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 492.0
TLS1_k127_7133410_5 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 399.0
TLS1_k127_7133410_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 332.0
TLS1_k127_7133410_7 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 328.0
TLS1_k127_7133410_8 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001836 254.0
TLS1_k127_7133410_9 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000000000000000000000000002404 236.0
TLS1_k127_7211854_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 5.089e-199 629.0
TLS1_k127_7211854_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 497.0
TLS1_k127_7211854_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 475.0
TLS1_k127_7211854_3 ATPases associated with a variety of cellular activities K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005153 417.0
TLS1_k127_7211854_4 -O-antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 320.0
TLS1_k127_7211854_5 Transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 297.0
TLS1_k127_7211854_6 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000001844 176.0
TLS1_k127_7211854_7 alcohol dehydrogenase K00043 - 1.1.1.61 0.00000000000000000000005188 112.0
TLS1_k127_7211854_8 Uncharacterised protein family (UPF0261) - - - 0.000000000000000001244 88.0
TLS1_k127_7313845_0 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 2.83e-276 857.0
TLS1_k127_7313845_1 Periplasmic binding protein domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003863 551.0
TLS1_k127_7313845_10 ABC-type sugar transport system, ATPase component K10554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 400.0
TLS1_k127_7313845_11 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 394.0
TLS1_k127_7313845_12 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005178 374.0
TLS1_k127_7313845_13 Putative serine dehydratase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 359.0
TLS1_k127_7313845_14 ABC-type sugar transport system periplasmic component K17315 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 331.0
TLS1_k127_7313845_15 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006338 259.0
TLS1_k127_7313845_16 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000002563 169.0
TLS1_k127_7313845_17 - - - - 0.0000000000000000000000000000000009656 134.0
TLS1_k127_7313845_18 - - - - 0.0000000000000005241 79.0
TLS1_k127_7313845_2 ABC-type sugar transport system periplasmic component K10552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008165 529.0
TLS1_k127_7313845_3 Protein of unknown function (DUF1479) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 519.0
TLS1_k127_7313845_4 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00895,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 502.0
TLS1_k127_7313845_5 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 481.0
TLS1_k127_7313845_6 Xylulose kinase K00854 GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 484.0
TLS1_k127_7313845_7 Branched-chain amino acid transport system / permease component K10553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 471.0
TLS1_k127_7313845_8 PFAM 2-nitropropane dioxygenase NPD K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 450.0
TLS1_k127_7313845_9 ABC transporter K02056,K10554 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009565 400.0
TLS1_k127_7418146_0 AcrB/AcrD/AcrF family K03296,K18138 - - 0.0 1413.0
TLS1_k127_7418146_1 Branched-chain amino acid transport system / permease component K10440 - - 6.005e-308 960.0
TLS1_k127_7418146_10 Binding-protein-dependent transport systems inner membrane component - - - 8.107e-209 664.0
TLS1_k127_7418146_11 Aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 6.057e-205 656.0
TLS1_k127_7418146_12 Peptidase family M20/M25/M40 K06016 - 3.5.1.6,3.5.1.87 7.065e-200 631.0
TLS1_k127_7418146_13 ABC-type nitrate sulfonate bicarbonate transport K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 543.0
TLS1_k127_7418146_14 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006165 539.0
TLS1_k127_7418146_15 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 505.0
TLS1_k127_7418146_16 AMP-binding enzyme C-terminal domain K18661 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006317 507.0
TLS1_k127_7418146_17 Belongs to the binding-protein-dependent transport system permease family K10440,K10553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 496.0
TLS1_k127_7418146_18 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 496.0
TLS1_k127_7418146_19 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 489.0
TLS1_k127_7418146_2 pfkB family carbohydrate kinase K03338 - 2.7.1.92 3.528e-287 897.0
TLS1_k127_7418146_20 Gluconolactonase K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 464.0
TLS1_k127_7418146_21 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 467.0
TLS1_k127_7418146_22 Periplasmic binding protein-like domain K10439 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 436.0
TLS1_k127_7418146_23 ATPases associated with a variety of cellular activities K02056,K10545 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 416.0
TLS1_k127_7418146_24 ABC transporter K02056,K10545 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 414.0
TLS1_k127_7418146_25 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 410.0
TLS1_k127_7418146_26 Sugar phosphate isomerases epimerases K03335 - 4.2.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 410.0
TLS1_k127_7418146_27 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 415.0
TLS1_k127_7418146_28 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 399.0
TLS1_k127_7418146_29 ABC 3 transport family K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 394.0
TLS1_k127_7418146_3 Amidohydrolase family K01464 - 3.5.2.2 1.029e-269 836.0
TLS1_k127_7418146_30 Helix-turn-helix domain, rpiR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 390.0
TLS1_k127_7418146_31 Peptidase family M50 K06402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 389.0
TLS1_k127_7418146_32 ABC transporter K02074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006305 381.0
TLS1_k127_7418146_33 enzyme involved in inositol metabolism K03337 - 5.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 377.0
TLS1_k127_7418146_34 Ribosomal protein L11 methyltransferase (PrmA) K07320 - 2.1.1.298 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 372.0
TLS1_k127_7418146_35 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 372.0
TLS1_k127_7418146_36 5-formyltetrahydrofolate cycloligase K01934 - 6.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 355.0
TLS1_k127_7418146_37 dihydrofolate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 344.0
TLS1_k127_7418146_38 Aldo keto reductase - GO:0003674,GO:0003824,GO:0006081,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046185,GO:0051596,GO:0055114,GO:0071704,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005748 346.0
TLS1_k127_7418146_39 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 343.0
TLS1_k127_7418146_4 TIGRFAM FGGY-family pentulose kinase - - - 3.071e-262 816.0
TLS1_k127_7418146_40 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 352.0
TLS1_k127_7418146_41 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 339.0
TLS1_k127_7418146_42 Belongs to the bacterial solute-binding protein 9 family K02075,K02077,K09815,K11707 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006994 340.0
TLS1_k127_7418146_43 HlyD family secretion protein K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 342.0
TLS1_k127_7418146_44 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 331.0
TLS1_k127_7418146_45 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 340.0
TLS1_k127_7418146_46 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 326.0
TLS1_k127_7418146_47 IQR COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007184 318.0
TLS1_k127_7418146_48 Aldose 1-epimerase K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 322.0
TLS1_k127_7418146_49 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 290.0
TLS1_k127_7418146_5 ATP-dependent helicase K03579 - 3.6.4.13 1.265e-255 812.0
TLS1_k127_7418146_50 Bacterial regulatory proteins, tetR family K09017 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004389 254.0
TLS1_k127_7418146_51 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001749 258.0
TLS1_k127_7418146_52 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000127 254.0
TLS1_k127_7418146_53 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008919 241.0
TLS1_k127_7418146_54 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000001526 237.0
TLS1_k127_7418146_55 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000000000001558 219.0
TLS1_k127_7418146_56 Glucokinase K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000004963 223.0
TLS1_k127_7418146_57 protein containing double-stranded beta helix domain - - - 0.000000000000000000000000000000000000000000000000000000365 195.0
TLS1_k127_7418146_58 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000004744 191.0
TLS1_k127_7418146_59 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000178 163.0
TLS1_k127_7418146_6 Dehydratase family K01690 - 4.2.1.12 3.42e-249 782.0
TLS1_k127_7418146_60 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000001956 156.0
TLS1_k127_7418146_61 Universal stress protein - - - 0.0000000000000000000000000000000000001678 152.0
TLS1_k127_7418146_62 Uncharacterized conserved protein (DUF2277) - - - 0.0000000000000000000000000000000000002888 142.0
TLS1_k127_7418146_63 TadE-like protein K02651 - - 0.0000000000000000000000000000000008484 139.0
TLS1_k127_7418146_64 - - - - 0.00000000000000000000000000002626 122.0
TLS1_k127_7418146_65 Ferric uptake regulator family K09823 - - 0.00000000000000000000000000005242 120.0
TLS1_k127_7418146_66 CsbD-like - - - 0.000000000000000000000000001016 113.0
TLS1_k127_7418146_67 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00000000000000000000000001062 116.0
TLS1_k127_7418146_68 Pilus formation protein N terminal region - - - 0.0000000000000000009833 93.0
TLS1_k127_7418146_69 - - - - 0.000000000000001587 78.0
TLS1_k127_7418146_7 Glycosyltransferase like family 2 K00694 - 2.4.1.12 1.839e-222 714.0
TLS1_k127_7418146_70 Flp pilus assembly protein TadG - - - 0.0000000000004144 78.0
TLS1_k127_7418146_71 - - - - 0.0000000003755 63.0
TLS1_k127_7418146_8 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.458e-220 695.0
TLS1_k127_7418146_9 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 1.214e-214 676.0
TLS1_k127_7469515_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1133.0
TLS1_k127_7469515_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0 1058.0
TLS1_k127_7469515_10 NusA-like KH domain K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 574.0
TLS1_k127_7469515_11 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 556.0
TLS1_k127_7469515_12 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 543.0
TLS1_k127_7469515_13 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 516.0
TLS1_k127_7469515_14 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008346 486.0
TLS1_k127_7469515_15 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000089 453.0
TLS1_k127_7469515_16 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 443.0
TLS1_k127_7469515_17 Belongs to the prokaryotic GSH synthase family K01920 GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 439.0
TLS1_k127_7469515_18 HemN C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 436.0
TLS1_k127_7469515_19 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 413.0
TLS1_k127_7469515_2 Heat shock 70 kDa protein K04043 - - 0.0 1052.0
TLS1_k127_7469515_20 COG0524 Sugar kinases, ribokinase family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002831 405.0
TLS1_k127_7469515_21 Histidine biosynthesis protein K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 400.0
TLS1_k127_7469515_22 Short-chain dehydrogenase reductase sdr K22185 - 1.1.1.175 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 377.0
TLS1_k127_7469515_23 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006818 381.0
TLS1_k127_7469515_24 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 381.0
TLS1_k127_7469515_25 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 356.0
TLS1_k127_7469515_26 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 358.0
TLS1_k127_7469515_27 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009744 344.0
TLS1_k127_7469515_28 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006962 336.0
TLS1_k127_7469515_29 Phosphoglycerate mutase family K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 325.0
TLS1_k127_7469515_3 Dehydratase family K01687,K22186 - 4.2.1.82,4.2.1.9 0.0 1004.0
TLS1_k127_7469515_30 Uroporphyrinogen decarboxylase (URO-D) K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 329.0
TLS1_k127_7469515_31 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 312.0
TLS1_k127_7469515_32 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 306.0
TLS1_k127_7469515_33 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 310.0
TLS1_k127_7469515_34 Acetyltransferase (GNAT) domain K22310 - 2.3.2.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 296.0
TLS1_k127_7469515_35 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 291.0
TLS1_k127_7469515_36 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008255 282.0
TLS1_k127_7469515_37 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000172 284.0
TLS1_k127_7469515_38 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001793 279.0
TLS1_k127_7469515_39 Transporter associated domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009417 283.0
TLS1_k127_7469515_4 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.56e-312 983.0
TLS1_k127_7469515_40 LppC putative lipoprotein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001001 288.0
TLS1_k127_7469515_41 Scaffold protein Nfu/NifU N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001506 275.0
TLS1_k127_7469515_42 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003636 276.0
TLS1_k127_7469515_43 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005304 274.0
TLS1_k127_7469515_44 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000001876 250.0
TLS1_k127_7469515_45 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000001298 251.0
TLS1_k127_7469515_46 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000004755 246.0
TLS1_k127_7469515_47 PFAM 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.000000000000000000000000000000000000000000000000000000000000000003631 247.0
TLS1_k127_7469515_48 PFAM import inner membrane translocase subunit Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000001193 227.0
TLS1_k127_7469515_49 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000002138 211.0
TLS1_k127_7469515_5 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 3.208e-243 759.0
TLS1_k127_7469515_50 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000002396 211.0
TLS1_k127_7469515_51 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000008317 211.0
TLS1_k127_7469515_52 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000000000000000000000000000000000000000000000003116 206.0
TLS1_k127_7469515_53 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000257 195.0
TLS1_k127_7469515_54 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000001781 185.0
TLS1_k127_7469515_55 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000002911 183.0
TLS1_k127_7469515_56 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000557 181.0
TLS1_k127_7469515_57 Acetyltransferase - - - 0.000000000000000000000000000000000000000000000001881 180.0
TLS1_k127_7469515_58 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000001187 167.0
TLS1_k127_7469515_59 Smr domain - - - 0.00000000000000000000000000000000000000000002842 168.0
TLS1_k127_7469515_6 ATPase associated with various cellular activities AAA_5 K07391 - - 7.014e-222 698.0
TLS1_k127_7469515_60 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000001191 164.0
TLS1_k127_7469515_61 Glycoprotease family K01409,K14742 - 2.3.1.234 0.000000000000000000000000000000000000000000121 173.0
TLS1_k127_7469515_62 Uncharacterised protein family (UPF0093) K08973 - - 0.0000000000000000000000000000000000000000001281 165.0
TLS1_k127_7469515_63 Etoposide-induced protein 2.4 (EI24) K06203 - - 0.0000000000000000000000000000000000000000001456 169.0
TLS1_k127_7469515_64 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000000000001118 143.0
TLS1_k127_7469515_65 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000000000002495 139.0
TLS1_k127_7469515_66 FR47-like protein K03789 - 2.3.1.128 0.00000000000000000000000001304 123.0
TLS1_k127_7469515_67 Integral membrane protein (DUF2244) - - - 0.00000000000000000000001755 107.0
TLS1_k127_7469515_68 Belongs to the UPF0102 family K07460 - - 0.000000000000000000001319 98.0
TLS1_k127_7469515_69 Phosphoribosyl-AMP cyclohydrolase K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.00000000000000002745 87.0
TLS1_k127_7469515_7 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.872e-212 672.0
TLS1_k127_7469515_70 Protein of unknown function (DUF2628) - - - 0.00000000000000002792 87.0
TLS1_k127_7469515_8 Belongs to the AdoMet synthase family K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 2.148e-199 627.0
TLS1_k127_7469515_9 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 584.0
TLS1_k127_7592210_0 Sir2 family K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 317.0
TLS1_k127_7592210_1 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000004267 242.0
TLS1_k127_7592210_2 Cold shock protein domain K03704 - - 0.0000000000000000000000000000000000000000000000000000000000003319 217.0
TLS1_k127_7592210_3 binding protein component of ABC transporter K11069 - - 0.00000000000000000000000000000000000000000000006491 170.0
TLS1_k127_7592210_4 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000003412 139.0
TLS1_k127_7592210_5 ETC complex I subunit conserved region K00329 - 1.6.5.3 0.00000000000000000000000000000001792 130.0
TLS1_k127_7592210_6 - - - - 0.000008244 55.0
TLS1_k127_7592210_7 - - - - 0.0001344 46.0
TLS1_k127_7612399_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.137e-208 661.0
TLS1_k127_7612399_1 Serine hydroxymethyltransferase - - - 1.043e-205 647.0
TLS1_k127_7612399_10 Putative peptidoglycan binding domain K21470,K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 326.0
TLS1_k127_7612399_11 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000118 282.0
TLS1_k127_7612399_12 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000248 258.0
TLS1_k127_7612399_13 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000003523 259.0
TLS1_k127_7612399_14 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000006681 236.0
TLS1_k127_7612399_15 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000001647 217.0
TLS1_k127_7612399_16 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000001989 175.0
TLS1_k127_7612399_17 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000001884 161.0
TLS1_k127_7612399_18 EamA-like transporter family - - - 0.00000000000000000000000000000000000009929 153.0
TLS1_k127_7612399_19 protein conserved in bacteria - - - 0.0000000000000000000000000000000001885 145.0
TLS1_k127_7612399_2 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 540.0
TLS1_k127_7612399_3 ACT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008791 495.0
TLS1_k127_7612399_4 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 469.0
TLS1_k127_7612399_5 Dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 433.0
TLS1_k127_7612399_6 TIGRFAM drug resistance transporter, Bcr CflA subfamily K07552 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 419.0
TLS1_k127_7612399_7 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 372.0
TLS1_k127_7612399_8 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 348.0
TLS1_k127_7612399_9 Arginine-tRNA-protein transferase, N terminus K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 313.0
TLS1_k127_7799126_0 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 402.0
TLS1_k127_7799126_1 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002171 278.0
TLS1_k127_7894885_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1420.0
TLS1_k127_7894885_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.036e-284 889.0
TLS1_k127_7894885_10 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 607.0
TLS1_k127_7894885_11 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 605.0
TLS1_k127_7894885_12 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 598.0
TLS1_k127_7894885_13 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003471 569.0
TLS1_k127_7894885_14 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001963 569.0
TLS1_k127_7894885_15 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 555.0
TLS1_k127_7894885_16 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00383 GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 548.0
TLS1_k127_7894885_17 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 536.0
TLS1_k127_7894885_18 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 534.0
TLS1_k127_7894885_19 ABC-type dipeptide oligopeptide nickel transport K15582 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006402 524.0
TLS1_k127_7894885_2 Belongs to the TPP enzyme family K03852 - 2.3.3.15 4.054e-282 876.0
TLS1_k127_7894885_20 Required for the activity of the bacterial periplasmic transport system of putrescine K11069,K11073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 497.0
TLS1_k127_7894885_21 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 503.0
TLS1_k127_7894885_22 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 487.0
TLS1_k127_7894885_23 Cys/Met metabolism PLP-dependent enzyme K01761 - 4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 471.0
TLS1_k127_7894885_24 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 443.0
TLS1_k127_7894885_25 Peptidase M16 inactive domain K07263,K07623 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 435.0
TLS1_k127_7894885_26 FAD dependent oxidoreductase K09471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 430.0
TLS1_k127_7894885_27 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 424.0
TLS1_k127_7894885_28 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 432.0
TLS1_k127_7894885_29 Belongs to the arginase family K01479,K01480 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11,3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 413.0
TLS1_k127_7894885_3 Tripartite tricarboxylate transporter TctA family - - - 1.77e-253 796.0
TLS1_k127_7894885_30 Putrescine transport system permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 394.0
TLS1_k127_7894885_31 epimerase dehydratase K01784,K19997 - 5.1.3.2,5.1.3.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 379.0
TLS1_k127_7894885_32 Alpha/beta hydrolase family K01561 - 3.8.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 369.0
TLS1_k127_7894885_33 Binding-protein-dependent transport system inner membrane component K11070,K11074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 364.0
TLS1_k127_7894885_34 transporter, permease K02033,K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 359.0
TLS1_k127_7894885_35 S4 RNA-binding domain K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 332.0
TLS1_k127_7894885_36 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 291.0
TLS1_k127_7894885_37 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006854 284.0
TLS1_k127_7894885_38 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004866 270.0
TLS1_k127_7894885_39 phosphate acetyltransferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008552 273.0
TLS1_k127_7894885_4 ABC transporter transmembrane region K06147 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576 - 2.259e-245 773.0
TLS1_k127_7894885_40 RarD protein, DMT superfamily transporter K05786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001104 263.0
TLS1_k127_7894885_41 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000004307 256.0
TLS1_k127_7894885_42 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000001521 247.0
TLS1_k127_7894885_43 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000007426 241.0
TLS1_k127_7894885_44 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000000000000000000001078 237.0
TLS1_k127_7894885_45 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000008381 216.0
TLS1_k127_7894885_46 Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000381 209.0
TLS1_k127_7894885_47 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K01487,K11991 - 3.5.4.1,3.5.4.3,3.5.4.33 0.000000000000000000000000000000000000000000000000000000001743 203.0
TLS1_k127_7894885_48 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000000000007814 212.0
TLS1_k127_7894885_49 LysM domain - - - 0.0000000000000000000000000000000000000000000000000001961 206.0
TLS1_k127_7894885_5 ABC-type oligopeptide transport system periplasmic component K02035,K15580 - - 2.114e-244 764.0
TLS1_k127_7894885_50 COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein - - - 0.00000000000000000000000000000000000000000000000002347 184.0
TLS1_k127_7894885_51 PFAM Cupin 2 conserved barrel domain protein K21700 - - 0.00000000000000000000000000000000000000000000006361 169.0
TLS1_k127_7894885_52 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.00000000000000000000000000000000000000000008608 169.0
TLS1_k127_7894885_53 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000004134 161.0
TLS1_k127_7894885_54 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000001365 155.0
TLS1_k127_7894885_55 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000000000000001464 151.0
TLS1_k127_7894885_56 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000002978 153.0
TLS1_k127_7894885_57 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000008348 124.0
TLS1_k127_7894885_58 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.0000000000000000000008028 96.0
TLS1_k127_7894885_59 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000952 76.0
TLS1_k127_7894885_6 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.396e-243 762.0
TLS1_k127_7894885_60 EamA-like transporter family K15270 - - 0.000000000005953 66.0
TLS1_k127_7894885_61 Major facilitator Superfamily - - - 0.000000000007981 68.0
TLS1_k127_7894885_7 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K13896,K15583 - - 1.68e-239 752.0
TLS1_k127_7894885_8 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 3.63e-237 741.0
TLS1_k127_7894885_9 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 5.21e-214 681.0
TLS1_k127_7904369_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564 3.4.21.83 1.612e-288 902.0
TLS1_k127_7904369_1 Bacterial protein of unknown function (DUF853) K06915 - - 1.503e-202 641.0
TLS1_k127_7904369_10 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000003179 192.0
TLS1_k127_7904369_11 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000007497 178.0
TLS1_k127_7904369_12 Fe-S metabolism associated SufE K02426 - - 0.0000000000000000000000000000000000000000004066 162.0
TLS1_k127_7904369_13 Acetyltransferase K03829 - - 0.00000000000000000000000000000000000004554 147.0
TLS1_k127_7904369_14 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000001553 145.0
TLS1_k127_7904369_15 Putative ATP-dependant zinc protease - - - 0.00000000000000000000000000000001863 132.0
TLS1_k127_7904369_16 PAS domain - - - 0.0000000000000000000000000000003367 129.0
TLS1_k127_7904369_17 Protein of unknown function (DUF1491) - - - 0.00000000000000000000000009949 110.0
TLS1_k127_7904369_18 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000001083 124.0
TLS1_k127_7904369_19 Protein of unknown function (DUF1214) - - - 0.000000000000000000000002991 109.0
TLS1_k127_7904369_2 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 4.672e-202 654.0
TLS1_k127_7904369_20 - - - - 0.00000000000000000000004909 104.0
TLS1_k127_7904369_21 PFAM Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.000000000000001525 86.0
TLS1_k127_7904369_22 Putative peptidoglycan binding domain - - - 0.00000000000008833 80.0
TLS1_k127_7904369_23 integral membrane protein - - - 0.0000000002894 71.0
TLS1_k127_7904369_24 Protein of unknown function (DUF3168) - - - 0.0008692 46.0
TLS1_k127_7904369_3 Acyl-CoA dehydrogenase, N-terminal domain K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 593.0
TLS1_k127_7904369_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009693 499.0
TLS1_k127_7904369_5 Belongs to the RimK family K05844,K14940 - 6.3.2.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 450.0
TLS1_k127_7904369_6 succinylglutamate desuccinylase K06987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 393.0
TLS1_k127_7904369_7 PFAM Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 375.0
TLS1_k127_7904369_8 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 342.0
TLS1_k127_7904369_9 Belongs to the UPF0260 family K09160 - - 0.0000000000000000000000000000000000000000000000000000000000002318 214.0
TLS1_k127_7951624_0 Belongs to the GcvT family K00302 - 1.5.3.1 1.855e-260 826.0
TLS1_k127_7951624_1 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000428 397.0
TLS1_k127_7951624_2 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 383.0
TLS1_k127_7951624_3 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 387.0
TLS1_k127_7951624_4 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000003334 234.0
TLS1_k127_7951624_5 Phage lysozyme K01185 - 3.2.1.17 0.0000000000000000000000000000000000000006364 159.0
TLS1_k127_7951624_6 Protein of unknown function (DUF2793) - - - 0.0000000000000000000007693 109.0
TLS1_k127_7951624_7 Sarcosine oxidase, gamma subunit family K00305 - 1.5.3.1 0.000000000000000000001183 104.0
TLS1_k127_7951624_8 Holin of 3TMs, for gene-transfer release - - - 0.00000000000000000008638 95.0
TLS1_k127_7956427_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.23e-319 992.0
TLS1_k127_7956427_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.469e-311 964.0
TLS1_k127_7956427_10 Sugar ABC transporter ATP-binding protein K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 396.0
TLS1_k127_7956427_11 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 382.0
TLS1_k127_7956427_12 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 365.0
TLS1_k127_7956427_13 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 364.0
TLS1_k127_7956427_14 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006127 264.0
TLS1_k127_7956427_15 Belongs to the DnaA family - - - 0.0000000000000000000000000000000000000000000000000000000000000002397 228.0
TLS1_k127_7956427_16 Formyl transferase K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000004022 222.0
TLS1_k127_7956427_17 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000009046 195.0
TLS1_k127_7956427_18 CDP-alcohol phosphatidyltransferase K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000002954 188.0
TLS1_k127_7956427_19 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.000000000000000000000000000000000000004416 167.0
TLS1_k127_7956427_2 sugar ABC transporter substrate-binding protein K10439 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004789 505.0
TLS1_k127_7956427_20 - - - - 0.00000001362 67.0
TLS1_k127_7956427_3 Belongs to the binding-protein-dependent transport system permease family K10440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 484.0
TLS1_k127_7956427_4 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 482.0
TLS1_k127_7956427_5 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 486.0
TLS1_k127_7956427_6 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 465.0
TLS1_k127_7956427_7 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 435.0
TLS1_k127_7956427_8 fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 409.0
TLS1_k127_7956427_9 AI-2E family transporter K03548 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 410.0
TLS1_k127_8009739_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 345.0
TLS1_k127_8009739_1 Invasion associated locus B - - - 0.00000000000000000000000000001494 126.0
TLS1_k127_8009739_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 0.0000000000000000003118 89.0