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Overview

ID MAG03975
Name TLS1_bin.17
Sample SMP0103
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Nitrososphaeria
Order Nitrososphaerales
Family Nitrososphaeraceae
Genus TH1177
Species TH1177 sp025922715
Assembly information
Completeness (%) 65.88
Contamination (%) 1.61
GC content (%) 30.0
N50 (bp) 2,767
Genome size (bp) 1,403,299

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1323

Gene name Description KEGG GOs EC E-value Score Sequence
TLS1_k127_1026313_0 von Willebrand factor (vWF) type A domain - - - 1.086e-222 702.0
TLS1_k127_1026313_1 ATPase family associated with various cellular activities (AAA) K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000183 265.0
TLS1_k127_1026313_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000002731 102.0
TLS1_k127_1089383_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 322.0
TLS1_k127_1114951_0 Belongs to the FPG family K05522 - 4.2.99.18 0.0000000000000000000001058 106.0
TLS1_k127_1114951_1 Belongs to the FPG family K05522 - 4.2.99.18 0.000005329 52.0
TLS1_k127_1114951_2 - - - - 0.00008125 51.0
TLS1_k127_1117110_0 COG0530 Ca2 Na antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 354.0
TLS1_k127_1117110_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00000000000005328 73.0
TLS1_k127_1117684_0 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006093 292.0
TLS1_k127_1117684_1 PFAM Protein kinase domain - - - 0.0000000008953 68.0
TLS1_k127_1122860_0 photosystem II stabilization - - - 0.000402 51.0
TLS1_k127_1131081_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 395.0
TLS1_k127_1131081_1 - - - - 0.00000000000000000000000000000000000000000000000006279 181.0
TLS1_k127_1131081_2 Protein phosphatase 2C K20074 - 3.1.3.16 0.000000000000000000000000000000000000000005144 163.0
TLS1_k127_1133960_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 355.0
TLS1_k127_1133960_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 330.0
TLS1_k127_1133960_2 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000003564 259.0
TLS1_k127_1180240_0 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 482.0
TLS1_k127_1180240_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000008634 241.0
TLS1_k127_1180240_2 - - - - 0.0000000006814 60.0
TLS1_k127_1181305_0 NAD(P)H-dependent FMN reductase K00299 - 1.5.1.38 0.0000000000000000000000000000000000000000000000000000000000000000001201 235.0
TLS1_k127_1181305_1 - - - - 0.00000000000000000000000000000000000007309 145.0
TLS1_k127_1185560_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008146 440.0
TLS1_k127_1185560_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000004449 226.0
TLS1_k127_1185560_2 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000003082 118.0
TLS1_k127_1185560_3 - - - - 0.00000000000000000000001162 104.0
TLS1_k127_1185560_4 Iron/zinc purple acid phosphatase-like protein C K22390 - - 0.00000000000000005215 94.0
TLS1_k127_1189041_0 COG3316 Transposase and inactivated derivatives - - - 0.00000004278 63.0
TLS1_k127_119820_0 Transcriptional regulatory protein, C terminal - - - 0.000000005269 61.0
TLS1_k127_120450_0 - - - - 0.00000000000000000000001046 106.0
TLS1_k127_1222547_0 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 476.0
TLS1_k127_1222547_1 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000138 201.0
TLS1_k127_1222547_2 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000002069 175.0
TLS1_k127_1243170_0 Lipolytic acyl hydrolase (LAH) - - - 0.0000000000000000000000000000000000001032 143.0
TLS1_k127_1243170_1 lipolytic acyl hydrolase (LAH) - - - 0.00000000000000000000009559 98.0
TLS1_k127_1271810_0 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000001348 220.0
TLS1_k127_1314449_0 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000000000000000000000004251 223.0
TLS1_k127_133174_0 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction K08482 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007623,GO:0008150,GO:0008152,GO:0009605,GO:0009649,GO:0009966,GO:0009987,GO:0010646,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0023051,GO:0036211,GO:0042752,GO:0042754,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0048511,GO:0048519,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070297,GO:0071704,GO:1901564,GO:1902531 - 0.0000000000000000000000000000000000000000000187 180.0
TLS1_k127_1380086_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000005804 222.0
TLS1_k127_1380086_1 Histidine kinase - - - 0.000000000000000000000000003222 118.0
TLS1_k127_1380086_2 response regulator, receiver - - - 0.0000000000000001495 81.0
TLS1_k127_1386750_0 This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation K02707,K02713 - - 0.000000000000000000000000000000000000000000000000005317 181.0
TLS1_k127_1386750_1 This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation K02707,K02713 - - 0.000000000000000000000000005731 109.0
TLS1_k127_1386750_2 Photosystem II protein J K02711 - - 0.00000000000000000000007855 97.0
TLS1_k127_1386750_3 Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions K02635 GO:0005575,GO:0005622,GO:0005623,GO:0009512,GO:0009579,GO:0016020,GO:0032991,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464,GO:0070069 - 0.00000009054 53.0
TLS1_k127_1386750_5 cytochrome b6 K02635,K02704 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - 0.000002897 49.0
TLS1_k127_138847_0 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000002478 145.0
TLS1_k127_1398769_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 485.0
TLS1_k127_1398769_1 - - - - 0.00000000000000000000000000000000005217 134.0
TLS1_k127_1398769_2 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000005787 133.0
TLS1_k127_1401076_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1395.0
TLS1_k127_1412183_0 PFAM Coenzyme A transferase K01026 - 2.8.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 407.0
TLS1_k127_1412183_1 ZIP Zinc transporter K07238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 336.0
TLS1_k127_1420894_0 3-hydroxyacyl-CoA dehydrogenase K15016 - 1.1.1.35,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000112 242.0
TLS1_k127_1420894_1 PFAM Iron dependent repressor, metal binding and dimerisation domain K03709 - - 0.00000000000000000000000000000000000000000000000000000000000000000002871 235.0
TLS1_k127_1428562_0 small GTP-binding protein K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 447.0
TLS1_k127_1428562_1 Signal peptidase K13280 - 3.4.21.89 0.00000000000000000000000000000000000000000000000001147 185.0
TLS1_k127_1428562_2 Reverse transcriptase-like K02226,K22316 GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 3.1.26.4,3.1.3.73 0.000002807 51.0
TLS1_k127_14727_0 High-affinity Fe2 Pb2 permease K07243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006684 352.0
TLS1_k127_14727_1 Iron permease FTR1 family K07243 - - 0.0000000000000001144 86.0
TLS1_k127_1475500_0 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 4.856e-220 687.0
TLS1_k127_1475500_2 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000001357 52.0
TLS1_k127_15010_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 372.0
TLS1_k127_15010_1 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 348.0
TLS1_k127_15010_2 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000005365 168.0
TLS1_k127_15010_3 - - - - 0.00000000000008145 72.0
TLS1_k127_15010_4 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.0000000001333 68.0
TLS1_k127_1508468_0 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000006401 218.0
TLS1_k127_1508468_1 - - - - 0.0000000000000000000004135 103.0
TLS1_k127_151284_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000005421 232.0
TLS1_k127_151284_1 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000007588 157.0
TLS1_k127_1517542_0 AAA domain K07028 - - 0.00000000000000000000000000000000000000000000000000000000000311 220.0
TLS1_k127_1517542_1 AAA domain K07028 - - 0.0006648 44.0
TLS1_k127_1520318_0 Thioredoxin K03671 - - 0.000000000000000000000000000000002696 130.0
TLS1_k127_1520318_1 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000002883 95.0
TLS1_k127_1520318_2 Mediates influx of magnesium ions K03284 - - 0.0000000000004529 75.0
TLS1_k127_1520318_3 Mediates influx of magnesium ions K03284 - - 0.0003277 47.0
TLS1_k127_1542509_0 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000003706 96.0
TLS1_k127_1542509_1 Protein of unknown function (DUF1264) - - - 0.0000000000000000003608 94.0
TLS1_k127_1555637_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 430.0
TLS1_k127_1555637_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000005759 174.0
TLS1_k127_1555637_2 amidohydrolase - - - 0.000000000000005648 77.0
TLS1_k127_15836_0 Initiation factor K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 289.0
TLS1_k127_15836_1 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.00000000000000000000000000000000000000001447 156.0
TLS1_k127_1618540_0 S-adenosylmethionine synthetase K00789 - 2.5.1.6 1.142e-194 612.0
TLS1_k127_1618540_1 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000000000000000000000000000003405 171.0
TLS1_k127_1618540_2 RecA RadA K04482,K04483 - - 0.0000000000000000000000000000000000000009405 156.0
TLS1_k127_1618540_3 snRNP Sm proteins K04796 - - 0.0000000000000000000000000000001286 128.0
TLS1_k127_1618540_4 PUA domain K07575 - - 0.00000009584 54.0
TLS1_k127_16563_0 N-methylhydantoinase A acetone carboxylase, beta subunit - - - 5.701e-259 810.0
TLS1_k127_165827_0 pyridoxamine 5-phosphate K07005 - - 0.0000000000000000000000000000000000000000000133 166.0
TLS1_k127_165827_1 PAC2 family K06869 - - 0.0000000000000000000000000000000000000004573 154.0
TLS1_k127_1704421_0 Sulfite reductase K00392 - 1.8.7.1 5.646e-285 885.0
TLS1_k127_1704421_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008351 404.0
TLS1_k127_1704421_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 405.0
TLS1_k127_1704421_3 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.000000000000000000000000000000000000000000000000000000000002741 213.0
TLS1_k127_1704421_4 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000000000000000000000000000001968 147.0
TLS1_k127_1704421_5 tRNA pseudouridine synthase K06176 - 5.4.99.27 0.000000000000000000000000000323 117.0
TLS1_k127_1704421_6 transcription factor, homolog of eukaryotic MBF1 K03627 - - 0.00000000000000004417 84.0
TLS1_k127_1716975_0 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 544.0
TLS1_k127_1785879_0 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003403 268.0
TLS1_k127_1785879_1 - - - - 0.0000000000000000000000000000000276 133.0
TLS1_k127_1791296_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000005978 201.0
TLS1_k127_1791296_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00001581 48.0
TLS1_k127_1859243_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 3.863e-256 804.0
TLS1_k127_1859243_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 542.0
TLS1_k127_186513_0 Transcriptional regulator - - - 0.000000000000006193 77.0
TLS1_k127_186513_1 Protein tyrosine kinase - - - 0.00000000000002572 81.0
TLS1_k127_186513_2 PFAM blue (type 1) copper domain protein - - - 0.0001873 50.0
TLS1_k127_1930994_0 Cupredoxin-like domain - - - 0.00000000000000000000000000000000919 133.0
TLS1_k127_1930994_1 - - - - 0.0000000000000000000000000000586 120.0
TLS1_k127_1930994_2 Winged helix-turn-helix - - - 0.00000000000000000000004912 100.0
TLS1_k127_1937716_0 Mg2 transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 383.0
TLS1_k127_1937716_1 - - - - 0.0000000000000000000000001193 111.0
TLS1_k127_1945694_0 oxidation-reduction process K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000005419 169.0
TLS1_k127_1945694_1 - - - - 0.00002102 54.0
TLS1_k127_2007504_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000006794 242.0
TLS1_k127_2007504_1 NUDIX domain - - - 0.000000000000000000000000000000001901 135.0
TLS1_k127_2007504_2 - - - - 0.000000000000000000000000000000003114 130.0
TLS1_k127_2007504_3 - - - - 0.00000000000000000001554 95.0
TLS1_k127_2027421_0 ABC1 family - - - 4.574e-205 649.0
TLS1_k127_2027421_1 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 462.0
TLS1_k127_2027421_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000007972 192.0
TLS1_k127_2027421_3 Patch-forming domain C2 of tRNA-guanine transglycosylase K07398 - - 0.0000000000000000000000000000000000000000000000003627 179.0
TLS1_k127_2027421_4 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000000000000000000000000000000000000000000000006569 173.0
TLS1_k127_2027421_5 - - - - 0.00000000000000000000000000000000000002057 147.0
TLS1_k127_2027421_6 transcription factor, homolog of eukaryotic MBF1 K03627 - - 0.000000001637 60.0
TLS1_k127_2037264_0 - - - - 0.00000000001114 70.0
TLS1_k127_2080750_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 574.0
TLS1_k127_2080750_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000003206 130.0
TLS1_k127_2080750_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000001237 66.0
TLS1_k127_2104580_0 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000003482 93.0
TLS1_k127_2110021_0 DNA methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000948 471.0
TLS1_k127_2110021_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000001431 248.0
TLS1_k127_2110021_2 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000004727 201.0
TLS1_k127_212688_0 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000000000000000000001483 153.0
TLS1_k127_212688_1 - - - - 0.0000000000000001412 84.0
TLS1_k127_212971_0 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003399 423.0
TLS1_k127_212971_1 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 402.0
TLS1_k127_212971_2 YHS domain - - - 0.0000000000000001407 79.0
TLS1_k127_212971_3 COG2931 RTX toxins and related Ca2 -binding - - - 0.0000000001167 68.0
TLS1_k127_212971_4 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0006341 44.0
TLS1_k127_2130567_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 3.247e-205 648.0
TLS1_k127_2130567_1 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 470.0
TLS1_k127_2130567_2 Radical SAM K11780 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007028 420.0
TLS1_k127_2130567_3 Delta-aminolevulinic acid dehydratase K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 289.0
TLS1_k127_2130567_4 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001901 253.0
TLS1_k127_2130567_5 - - - - 0.0000000000000000000000000000000002458 134.0
TLS1_k127_213155_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 395.0
TLS1_k127_2136617_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 352.0
TLS1_k127_2136617_1 Protocatechuate 3,4-dioxygenase beta subunit - - - 0.0000000000000000000000000000009855 125.0
TLS1_k127_2136617_2 flavodoxin nitric oxide synthase - - - 0.00000000000000000000002826 99.0
TLS1_k127_213957_0 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000001391 162.0
TLS1_k127_2157822_0 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 398.0
TLS1_k127_2157822_1 ThiJ PfpI - - - 0.000000000000000000000000000000000000000000000000000000000000000335 226.0
TLS1_k127_2157822_2 GYD domain - - - 0.00000000003381 66.0
TLS1_k127_216566_0 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 290.0
TLS1_k127_216566_1 Bacterial protein of unknown function (DUF839) - - - 0.000005131 57.0
TLS1_k127_2172896_0 Formyl transferase K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 366.0
TLS1_k127_2172896_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000001916 229.0
TLS1_k127_218176_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000001769 243.0
TLS1_k127_218176_1 Transposase DDE domain K07492 - - 0.0000000000000000000000000000001199 127.0
TLS1_k127_218176_2 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000000000000002561 114.0
TLS1_k127_2184524_0 COG3547 Transposase and inactivated derivatives - - - 0.000000001093 60.0
TLS1_k127_2184524_1 COG3547 Transposase and inactivated derivatives - - - 0.00003569 48.0
TLS1_k127_2185948_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000005613 194.0
TLS1_k127_2279_0 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 584.0
TLS1_k127_2279_1 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 498.0
TLS1_k127_2279_10 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000001377 255.0
TLS1_k127_2279_11 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001103 260.0
TLS1_k127_2279_12 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000001072 252.0
TLS1_k127_2279_2 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 477.0
TLS1_k127_2279_3 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 472.0
TLS1_k127_2279_4 Glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008663 453.0
TLS1_k127_2279_5 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 392.0
TLS1_k127_2279_6 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 325.0
TLS1_k127_2279_7 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 324.0
TLS1_k127_2279_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 284.0
TLS1_k127_2279_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000135 274.0
TLS1_k127_2292958_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0 1225.0
TLS1_k127_2292958_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000415 76.0
TLS1_k127_229551_0 Pyridoxamine 5'-phosphate - - - 0.000000000000000000000000000000000000000003603 160.0
TLS1_k127_229551_1 Hydrolase, alpha beta domain protein K00433 - 1.11.1.10 0.000000000000000000000000000000002711 134.0
TLS1_k127_229551_2 Serine aminopeptidase, S33 - - - 0.0000000000000004233 82.0
TLS1_k127_23115_0 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 313.0
TLS1_k127_23115_1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.0000000002501 68.0
TLS1_k127_234616_0 COG1653 ABC-type sugar transport system, periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 502.0
TLS1_k127_234616_1 aconitate hydratase K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 463.0
TLS1_k127_234616_2 PFAM ABC transporter related K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 357.0
TLS1_k127_234616_3 -transport system K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 296.0
TLS1_k127_234616_4 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 289.0
TLS1_k127_234887_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000009884 238.0
TLS1_k127_234887_1 Pyridoxamine 5'-phosphate - - - 0.00000000002939 65.0
TLS1_k127_2353980_0 Oxidoreductase family, NAD-binding Rossmann fold K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 341.0
TLS1_k127_2353980_1 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007272 250.0
TLS1_k127_2353980_2 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000004047 151.0
TLS1_k127_2353980_3 Trm112p-like protein - - - 0.0000000000000000000000005618 108.0
TLS1_k127_2433330_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 492.0
TLS1_k127_2433330_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 474.0
TLS1_k127_2433330_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 349.0
TLS1_k127_2433330_3 Amino acid kinase family K06981 - 2.7.4.26 0.000000000000000003866 88.0
TLS1_k127_2434724_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 427.0
TLS1_k127_2436411_0 HMGL-like K01649 - 2.3.3.13 4.043e-214 670.0
TLS1_k127_2436411_1 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 553.0
TLS1_k127_2436411_2 Lysine biosynthesis K05827 - 6.3.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 411.0
TLS1_k127_2436411_3 diphthine synthase K20215 - 2.1.1.98 0.000000000000000000000000000000000000000000000000000000000003272 214.0
TLS1_k127_2436411_4 helix_turn_helix ASNC type - - - 0.0000000000000000000000012 104.0
TLS1_k127_2436411_5 lysine biosynthesis protein LysW K05826 - - 0.0000000000000000000001017 97.0
TLS1_k127_2448824_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 580.0
TLS1_k127_2448824_1 Belongs to the SUI1 family K03113 - - 0.000000000000000000000000000000000000000000000000001231 184.0
TLS1_k127_2448824_2 Sec61beta family - - - 0.000000000000000000006889 93.0
TLS1_k127_2448824_3 Predicted membrane protein (DUF2070) K08979 - - 0.00000000000000001962 88.0
TLS1_k127_2492345_0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000002594 252.0
TLS1_k127_2548344_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0 1157.0
TLS1_k127_2548344_1 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004613 286.0
TLS1_k127_2565066_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008086 287.0
TLS1_k127_2565066_1 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 - 2.1.1.260 0.0000000000000000000000000000000000000000000000000000000203 204.0
TLS1_k127_2602446_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006379 271.0
TLS1_k127_2620937_0 inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 541.0
TLS1_k127_2620937_1 inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 471.0
TLS1_k127_2620937_2 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000000000000000000000000000000000000001171 175.0
TLS1_k127_2620937_3 - - - - 0.0000000000000000000000000000000000001097 144.0
TLS1_k127_2620937_4 Tetratricopeptide TPR-1 - - - 0.00000000000000000000000006306 119.0
TLS1_k127_2621373_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 5.883e-236 740.0
TLS1_k127_26396_0 4Fe-4S binding domain K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 306.0
TLS1_k127_2640900_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009141 337.0
TLS1_k127_2640900_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000233 224.0
TLS1_k127_2640900_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.000003242 53.0
TLS1_k127_2669349_0 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 528.0
TLS1_k127_2672297_0 DNA primase K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 565.0
TLS1_k127_2672297_1 Domain of unknown function DUF120 K07732 - 2.7.1.161 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003155 273.0
TLS1_k127_2672297_2 Cytidylyltransferase-like K00980,K14656 - 2.7.7.2,2.7.7.39 0.000000000000000000001274 94.0
TLS1_k127_2678829_0 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000000000000000000000000000003387 232.0
TLS1_k127_2678829_1 Binds to the 23S rRNA K02885 - - 0.00000000000000000000000000000000000000000000000000000000000183 211.0
TLS1_k127_2678829_2 ribosomal protein K02912 - - 0.0000000000000000000000000000000003189 133.0
TLS1_k127_2678829_3 - - - - 0.000000003321 59.0
TLS1_k127_2683385_0 FeS assembly protein SufB K09014 - - 3.112e-280 864.0
TLS1_k127_2683385_1 FeS assembly protein SufD K09014,K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 552.0
TLS1_k127_2683385_2 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000000000000000000006871 135.0
TLS1_k127_2683385_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000001001 117.0
TLS1_k127_2705070_0 DEAD/H associated K03724 - - 0.0 1182.0
TLS1_k127_2705070_1 Thiamine biosynthesis protein (ThiI) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 473.0
TLS1_k127_271755_0 Rad4 transglutaminase-like domain K01456 GO:0000224,GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006515,GO:0006516,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009100,GO:0009636,GO:0009719,GO:0009725,GO:0009751,GO:0009987,GO:0010033,GO:0010035,GO:0010188,GO:0010193,GO:0014070,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030163,GO:0036211,GO:0042221,GO:0042493,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051603,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901700 3.5.1.52 0.0000000000000000000000000003709 124.0
TLS1_k127_271755_1 - - - - 0.0000000000000000000000000006897 113.0
TLS1_k127_2730828_0 Probable cobalt transporter subunit (CbtA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004405 262.0
TLS1_k127_2730828_1 Domain of unknown function (DUF4443) - - - 0.0000000000000000000000000000000000000000009308 163.0
TLS1_k127_2730828_2 Probable cobalt transporter subunit (CbtB) - - - 0.00000000000000000002421 93.0
TLS1_k127_2750053_0 resistance protein K14166 - - 0.00000000000000000000000001212 118.0
TLS1_k127_2750053_1 resistance protein K14166 - - 0.000000000000000000000008376 110.0
TLS1_k127_2751074_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000003758 164.0
TLS1_k127_2751074_1 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000002489 162.0
TLS1_k127_2772536_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 7.7e-226 707.0
TLS1_k127_2772536_1 Belongs to the universal ribosomal protein uS5 family K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 342.0
TLS1_k127_2772536_2 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001304 267.0
TLS1_k127_2772536_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000000000000000008966 223.0
TLS1_k127_2772536_4 ribosomal protein K02907 - - 0.000000000000000000000000000000000000000000000000000007973 192.0
TLS1_k127_2772536_5 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000001119 140.0
TLS1_k127_2772536_6 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000001618 130.0
TLS1_k127_2772536_7 Belongs to the archaeal adenylate kinase family K00939 - 2.7.4.3 0.000000000000000000000000001261 115.0
TLS1_k127_2816568_0 component I K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 396.0
TLS1_k127_2816568_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001735 280.0
TLS1_k127_2885014_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 606.0
TLS1_k127_2885014_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 593.0
TLS1_k127_2885014_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 283.0
TLS1_k127_2885014_3 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000003869 228.0
TLS1_k127_2885014_4 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000000001254 173.0
TLS1_k127_2885014_5 SPTR Transposase, IS4 family protein - - - 0.000001858 54.0
TLS1_k127_2940730_0 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000005474 184.0
TLS1_k127_3081710_0 integrase family - - - 0.00000000000000000002847 94.0
TLS1_k127_308354_0 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 339.0
TLS1_k127_308354_1 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000001495 211.0
TLS1_k127_3140167_0 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.00000000000000000000000000000000000000000000000000000000000000000000000000001785 266.0
TLS1_k127_3140167_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000003579 66.0
TLS1_k127_3140167_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00002409 48.0
TLS1_k127_3146670_0 Putative tRNA binding domain K06878 - - 0.00000000000000000000000001879 112.0
TLS1_k127_3150847_0 Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a K00148 - 1.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 534.0
TLS1_k127_3150847_1 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000005743 243.0
TLS1_k127_3150847_2 PFAM Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000001499 192.0
TLS1_k127_3150847_3 COG1651 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000000000000001372 163.0
TLS1_k127_3150847_4 protein conserved in bacteria - - - 0.00000000000000000000004634 105.0
TLS1_k127_3151872_0 - - - - 0.0001542 50.0
TLS1_k127_3151872_1 flavodoxin nitric oxide synthase - - - 0.0003443 44.0
TLS1_k127_3151872_2 - - - - 0.000394 49.0
TLS1_k127_3171505_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 544.0
TLS1_k127_3171505_1 HIT domain K02503 - - 0.00000000000000000000000000000000000000000000005285 174.0
TLS1_k127_317883_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 580.0
TLS1_k127_317883_1 Tyrosine--tRNA ligase K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009173 495.0
TLS1_k127_317883_2 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934 - 2.1.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 456.0
TLS1_k127_317883_3 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 374.0
TLS1_k127_317883_4 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.00000000000000302 74.0
TLS1_k127_3188720_0 FR47-like protein K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000000000000000008283 254.0
TLS1_k127_3188720_1 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000005255 201.0
TLS1_k127_324422_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 576.0
TLS1_k127_324422_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 376.0
TLS1_k127_324422_2 Phosphoglycolate phosphatase K22223 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 296.0
TLS1_k127_324422_3 tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000001873 119.0
TLS1_k127_3246721_0 Belongs to the universal ribosomal protein uL14 family K02874 GO:0000313,GO:0000315,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005762,GO:0005840,GO:0009507,GO:0009532,GO:0009536,GO:0009547,GO:0009570,GO:0015934,GO:0019843,GO:0031974,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043253,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0070180,GO:0097159,GO:0098798,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001289 211.0
TLS1_k127_3246721_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000001083 194.0
TLS1_k127_3246721_2 50S ribosomal protein L16, chloroplastic K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000003165 117.0
TLS1_k127_3246721_3 Translation initiation factor IF-1 K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009507,GO:0009536,GO:0043021,GO:0043022,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000003006 76.0
TLS1_k127_327195_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000581 602.0
TLS1_k127_327195_1 Tetrapyrrole (Corrin/Porphyrin) Methylases K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008207 383.0
TLS1_k127_327195_2 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 292.0
TLS1_k127_327195_3 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000001214 255.0
TLS1_k127_327195_4 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000000000000000000000000000000000000000000000000000000000000000000005408 239.0
TLS1_k127_327195_5 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000001076 165.0
TLS1_k127_327195_6 - - - - 0.0000000000000000383 85.0
TLS1_k127_3285468_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000001599 202.0
TLS1_k127_3298397_0 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 567.0
TLS1_k127_3299030_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000002303 189.0
TLS1_k127_3321221_0 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000007691 201.0
TLS1_k127_3321221_1 low-complexity proteins - - - 0.000000000000000000000000000000000022 140.0
TLS1_k127_3321221_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000001096 113.0
TLS1_k127_3332577_0 Copper resistance protein D - - - 0.0000000000000000000000000000000000000005017 154.0
TLS1_k127_3332577_1 - - - - 0.000000000000000000000000009257 115.0
TLS1_k127_3332577_2 COG1522 Transcriptional regulators - - - 0.00000000000000000000009577 103.0
TLS1_k127_3332577_3 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 0.0000000000008059 70.0
TLS1_k127_3350835_0 Diphthamide biosynthesis K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 471.0
TLS1_k127_3350835_1 PP-loop family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 399.0
TLS1_k127_3350835_2 Transcriptional regulator K03718 - - 0.0000000000000009748 81.0
TLS1_k127_3355556_0 Arsenical pump membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 491.0
TLS1_k127_3388957_0 Photosystem II (PSII) is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1 D2 (PsbA PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors K02703 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.10.3.9 1.919e-234 726.0
TLS1_k127_3392232_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 9.893e-280 867.0
TLS1_k127_3392232_1 UbiD family decarboxylase K03182 - 4.1.1.98 1.886e-225 706.0
TLS1_k127_3392232_2 thioesterase - - - 0.000000000000000000000000000000000000000000000000001618 185.0
TLS1_k127_3398939_0 Succinyl-CoA ligase like flavodoxin domain K18594 - - 0.0 1037.0
TLS1_k127_3398939_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 4.792e-213 667.0
TLS1_k127_3398939_2 Iron-sulfur cluster assembly accessory protein K13628 - - 0.00000000000000000000000000000000000000000000000000000008691 196.0
TLS1_k127_3415720_0 Protein of unknown function (DUF4242) - - - 0.00000000000000000002173 92.0
TLS1_k127_3416547_0 cyclopropane-fatty-acyl-phospholipid synthase K20444 - - 0.00000000000000000000000000000000000000103 156.0
TLS1_k127_3416547_1 spore germination - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00007714 53.0
TLS1_k127_3428423_0 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000009432 216.0
TLS1_k127_3428423_1 CHRD domain - - - 0.000000000000000001137 93.0
TLS1_k127_3428423_2 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter K03190 - - 0.00000000000000005312 83.0
TLS1_k127_3429703_0 Protein of unknown function (DUF1254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 355.0
TLS1_k127_3429703_1 - - - - 0.00000000000000007723 85.0
TLS1_k127_3434166_0 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 8.279e-204 639.0
TLS1_k127_3434166_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 496.0
TLS1_k127_3434166_2 RNase L inhibitor, RLI K06174 - - 0.00000000000000000000000000000000000000000000000007491 180.0
TLS1_k127_3455196_0 - - - - 0.000000000000000000000000000000000000000000000004954 175.0
TLS1_k127_3455196_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000004362 176.0
TLS1_k127_3455196_2 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 0.000000009947 58.0
TLS1_k127_3459322_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01868 - 6.1.1.3 9.415e-271 846.0
TLS1_k127_3459322_1 transferase activity, transferring glycosyl groups K00752 - 2.4.1.212 0.00000000000000000000000000000000000000000000000000000000000000000000000004601 260.0
TLS1_k127_3459322_2 - - - - 0.000000000000000000008836 93.0
TLS1_k127_35835_0 Radical SAM - - - 0.0 1057.0
TLS1_k127_35835_1 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.000000000000000000000328 97.0
TLS1_k127_3626673_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 480.0
TLS1_k127_3626673_1 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 422.0
TLS1_k127_3626673_2 Cobalt chelatase (CbiK) K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000002691 201.0
TLS1_k127_3626673_3 Rio2, N-terminal K07179 GO:0002119,GO:0002164,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0007088,GO:0007275,GO:0007346,GO:0007399,GO:0008150,GO:0008152,GO:0008284,GO:0009791,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010564,GO:0010604,GO:0010628,GO:0010720,GO:0010965,GO:0014013,GO:0014015,GO:0016070,GO:0016072,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019219,GO:0019222,GO:0019538,GO:0022008,GO:0022613,GO:0030071,GO:0030154,GO:0030490,GO:0030684,GO:0030688,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032239,GO:0032241,GO:0032386,GO:0032388,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0033157,GO:0034470,GO:0034641,GO:0034660,GO:0036211,GO:0042127,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045597,GO:0045935,GO:0046483,GO:0046777,GO:0046822,GO:0046824,GO:0046825,GO:0046827,GO:0046831,GO:0046833,GO:0048518,GO:0048522,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050793,GO:0050794,GO:0051049,GO:0051050,GO:0051094,GO:0051128,GO:0051171,GO:0051173,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051252,GO:0051254,GO:0051726,GO:0051783,GO:0051960,GO:0051962,GO:0051983,GO:0060251,GO:0060252,GO:0060255,GO:0060284,GO:0060341,GO:0065007,GO:0070013,GO:0070201,GO:0071704,GO:0071840,GO:0080090,GO:0090069,GO:0090070,GO:0090087,GO:0090304,GO:0090316,GO:0140096,GO:1901360,GO:1901564,GO:1901987,GO:1901990,GO:1902099,GO:1903827,GO:1903829,GO:1904951,GO:1905818,GO:1990904,GO:2000026,GO:2000197,GO:2000199,GO:2000200,GO:2000202,GO:2000206,GO:2000208,GO:2000232,GO:2000234 2.7.11.1 0.000000001675 63.0
TLS1_k127_3642473_0 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001776 239.0
TLS1_k127_3642473_1 - - - - 0.0000000000000000000000000000000000000000000005301 171.0
TLS1_k127_3660324_0 Heavy metal transport detoxification protein K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 612.0
TLS1_k127_3660324_1 CHRD domain - - - 0.0000000000000000000000007637 110.0
TLS1_k127_3660324_2 Archaeal TRASH domain - - - 0.000000000000000008197 85.0
TLS1_k127_3675557_0 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 381.0
TLS1_k127_3694880_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008491 282.0
TLS1_k127_3694880_1 Belongs to the UPF0284 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000625 243.0
TLS1_k127_3694880_2 Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX K17759 - 5.1.99.6 0.000000000000000000000000000000000005813 140.0
TLS1_k127_3710843_0 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.0000000000000000000000000004501 117.0
TLS1_k127_3718739_0 40-residue YVTN family beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 316.0
TLS1_k127_3729718_0 Nickel-dependent hydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 297.0
TLS1_k127_3729718_1 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000007833 191.0
TLS1_k127_3729718_2 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit - - - 0.000000000000000001058 92.0
TLS1_k127_3731228_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 1.892e-225 709.0
TLS1_k127_3731886_0 Cytochrome b subunit of the bc complex K00412 - - 7.991e-249 776.0
TLS1_k127_3731886_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 354.0
TLS1_k127_3731886_2 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000982 332.0
TLS1_k127_3731886_3 helix_turn_helix ASNC type K03718 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001278 244.0
TLS1_k127_3731886_4 PFAM Copper binding proteins, plastocyanin azurin family - - - 0.000000000000000000000000000000000000000000000003273 177.0
TLS1_k127_3731886_5 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000003436 123.0
TLS1_k127_3731886_6 - - - - 0.000000000000000000000000000003149 124.0
TLS1_k127_3731886_8 PFAM Rieske 2Fe-2S domain - - - 0.00000000933 64.0
TLS1_k127_3731886_9 zinc finger - - - 0.0002033 46.0
TLS1_k127_373270_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01868 - 6.1.1.3 0.000000000000000000000000000000000000000001513 158.0
TLS1_k127_373270_1 - - - - 0.000004299 53.0
TLS1_k127_373270_2 Belongs to the glycosyl hydrolase 5 (cellulase A) family K05991 - 3.2.1.123 0.0000666 55.0
TLS1_k127_3744021_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 458.0
TLS1_k127_3744021_1 beta-glucosidase activity K05350 - 3.2.1.21 0.0000000000000001193 83.0
TLS1_k127_3744322_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.00001652 57.0
TLS1_k127_3744322_1 Protein of unknown function (DUF1211) - - - 0.0004972 46.0
TLS1_k127_3745401_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 2e-285 887.0
TLS1_k127_3745401_1 Belongs to the phosphohexose mutase family K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 581.0
TLS1_k127_3745401_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000002784 198.0
TLS1_k127_3745401_3 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.000000000000000000000000000000000000000000000000000003615 192.0
TLS1_k127_3745401_4 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000000008529 171.0
TLS1_k127_3745401_5 Formyl transferase K01433 - 3.5.1.10 0.0000000000000000000000000000000002512 136.0
TLS1_k127_3745401_6 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.000000000000000000000000000008332 119.0
TLS1_k127_3745401_7 Binds to the 23S rRNA K02896 - - 0.0000000000000000000000000000766 116.0
TLS1_k127_3745401_9 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000005347 96.0
TLS1_k127_3756244_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.0000000000000000000000000000000000000000000000000000000007915 213.0
TLS1_k127_3756244_1 Protein of unknown function DUF99 K09120 - - 0.000000000000000000000000000000000000000000000000006747 185.0
TLS1_k127_3756244_3 - - - - 0.000002193 56.0
TLS1_k127_3756577_0 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001782 283.0
TLS1_k127_3756577_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000003518 196.0
TLS1_k127_3756577_2 Nudix hydrolase K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000008579 178.0
TLS1_k127_3769368_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 493.0
TLS1_k127_3769368_1 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000002581 146.0
TLS1_k127_3769368_3 Major Facilitator Superfamily - - - 0.0000000000000000000001382 100.0
TLS1_k127_3770706_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 2.022e-283 878.0
TLS1_k127_3770706_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000614 421.0
TLS1_k127_3770706_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001185 248.0
TLS1_k127_3770706_3 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001022 242.0
TLS1_k127_3770706_4 Cytidylyltransferase-like K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000754 189.0
TLS1_k127_3770706_6 DNA topoisomerase, type IA, central domain protein K03168,K03169 - 5.99.1.2 0.00003529 49.0
TLS1_k127_3778957_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004194 265.0
TLS1_k127_3778957_1 Alpha beta - - - 0.000000006154 58.0
TLS1_k127_3790741_0 Translation initiation factor 2, alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 348.0
TLS1_k127_3790741_1 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000005748 244.0
TLS1_k127_3791901_0 Amino acid kinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 588.0
TLS1_k127_3791901_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 404.0
TLS1_k127_3791901_2 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 378.0
TLS1_k127_3791901_3 phosphoribosyltransferase K07101 - - 0.0000000000000000000005382 101.0
TLS1_k127_3792268_0 transcription factor jumonji K18850 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 0.000207 52.0
TLS1_k127_3792289_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 288.0
TLS1_k127_382_0 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000124 179.0
TLS1_k127_382_1 ChaB K06197 - - 0.00000000002488 66.0
TLS1_k127_3868229_0 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008802 494.0
TLS1_k127_3868229_1 Pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000005194 240.0
TLS1_k127_3868827_1 Rieske 2Fe-2S K05710 - - 0.0000000000000000000000000000000000000000005403 158.0
TLS1_k127_3868827_2 DUF167 K09131 - - 0.0006343 43.0
TLS1_k127_3872321_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 8.464e-264 820.0
TLS1_k127_3872321_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 534.0
TLS1_k127_3872321_2 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005998 493.0
TLS1_k127_3872321_3 PFAM SPFH domain Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 401.0
TLS1_k127_3872321_4 LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 383.0
TLS1_k127_3872321_5 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000006006 222.0
TLS1_k127_3872321_6 Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000001557 211.0
TLS1_k127_3872321_7 Cytidylyltransferase-like K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000000002402 213.0
TLS1_k127_3872321_8 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000002463 92.0
TLS1_k127_3876525_0 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 329.0
TLS1_k127_3876525_1 Sodium hydrogen exchanger K03455 - - 0.0000000000000004687 80.0
TLS1_k127_3876525_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000005756 52.0
TLS1_k127_3877002_0 Antibiotic biosynthesis monooxygenase K09932 - - 0.0000000000000000000000000000000000000002613 154.0
TLS1_k127_3877849_0 PFAM Ammonia monooxygenase methane monooxygenase, subunit C K10946 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 376.0
TLS1_k127_3877849_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 379.0
TLS1_k127_3877849_2 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008034 254.0
TLS1_k127_388112_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 305.0
TLS1_k127_388112_1 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001711 231.0
TLS1_k127_388112_2 iron dependent repressor - - - 0.000000000000000000001225 95.0
TLS1_k127_388112_3 iron dependent repressor - - - 0.000000000000000004824 86.0
TLS1_k127_3893849_0 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03635,K03637 - 2.8.1.12,4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 316.0
TLS1_k127_3893849_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 295.0
TLS1_k127_3893849_2 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009103 259.0
TLS1_k127_3893849_3 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000002695 183.0
TLS1_k127_3893849_4 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000001339 160.0
TLS1_k127_3893849_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.0000000000000000000000000655 111.0
TLS1_k127_3893849_6 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.0000001848 56.0
TLS1_k127_3894138_0 Peptidase family M1 domain K01256,K13722 - 3.4.11.2 0.00000000000000000000000000000000000000000000004352 190.0
TLS1_k127_3906000_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007023 329.0
TLS1_k127_3906000_1 Protein of unknown function (DUF2795) - - - 0.00000000000000000000000000000000000000000138 166.0
TLS1_k127_3907299_0 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001808 275.0
TLS1_k127_3907299_1 Cation efflux family K16264 - - 0.000000006154 58.0
TLS1_k127_3907299_2 Sensory domain in DIguanylate Cyclases and Two-component system - - - 0.0001347 51.0
TLS1_k127_3907484_1 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000001114 181.0
TLS1_k127_3918827_0 3-isopropylmalate dehydratase, large subunit K01703 - 4.2.1.33,4.2.1.35 1.851e-237 742.0
TLS1_k127_3918827_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 2.866e-201 632.0
TLS1_k127_3918827_2 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 2.242e-198 631.0
TLS1_k127_3918827_3 ThiF family K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 502.0
TLS1_k127_3918827_4 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 364.0
TLS1_k127_3918827_5 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000006523 243.0
TLS1_k127_3918827_6 PFAM Like-Sm ribonucleoprotein, core - - - 0.0000000000000000000000000000000000000000000000000000000006181 205.0
TLS1_k127_3918827_7 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000000000007043 149.0
TLS1_k127_3919599_0 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004946 254.0
TLS1_k127_3919599_1 F5/8 type C domain - - - 0.00000000000000000000000000000000000000000000004488 188.0
TLS1_k127_3919599_2 Purple acid Phosphatase, N-terminal domain - - - 0.000000000000000000000001625 119.0
TLS1_k127_3922415_0 ABC-type transport system, involved in lipoprotein release, permease component K02004 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 464.0
TLS1_k127_3922415_1 COG2931 RTX toxins and related Ca2 -binding proteins K01406 - 3.4.24.40 0.0000000001115 72.0
TLS1_k127_3925593_0 FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 422.0
TLS1_k127_3925593_1 Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008344 343.0
TLS1_k127_3925593_2 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 319.0
TLS1_k127_3925593_3 DNA-directed RNA polymerase, alpha subunit 40 kD subunit K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 312.0
TLS1_k127_3925593_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002704 243.0
TLS1_k127_3925593_5 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000000003748 232.0
TLS1_k127_3925593_6 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000008595 216.0
TLS1_k127_3925593_7 ribosomal protein K02883 - - 0.000000000000000000000000000000000000009185 148.0
TLS1_k127_3925593_8 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000002073 111.0
TLS1_k127_3925593_9 - - - - 0.0000001054 54.0
TLS1_k127_3950364_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000531 239.0
TLS1_k127_3951629_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000002296 177.0
TLS1_k127_3956411_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007996 297.0
TLS1_k127_3956411_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000154 216.0
TLS1_k127_3956411_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000006478 175.0
TLS1_k127_3956411_3 Cytidylyltransferase K19712 - 2.7.7.62 0.000000005184 63.0
TLS1_k127_401805_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002412 279.0
TLS1_k127_4029461_0 resistance protein K14166 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 475.0
TLS1_k127_4056693_0 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 352.0
TLS1_k127_4056693_1 K homology RNA-binding domain K06961 - - 0.0000000000000000000000000000000000000000000000000000001764 199.0
TLS1_k127_4056693_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000001883 175.0
TLS1_k127_4056693_3 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000005013 159.0
TLS1_k127_4056693_4 Protein of unknown function (DUF424) K09148 - - 0.0000000000000000002769 93.0
TLS1_k127_4079134_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 372.0
TLS1_k127_4084928_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 292.0
TLS1_k127_4084928_1 Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity K08096 - 3.5.4.29 0.000000000000000000000000000000000000000000000000000000000000000000007241 242.0
TLS1_k127_4084928_2 riboflavin synthase, alpha K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000009186 210.0
TLS1_k127_4084928_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000002274 168.0
TLS1_k127_4084928_4 Amidohydrolase family - - - 0.0000000000000000000000000000000002546 136.0
TLS1_k127_4087402_0 - - - - 0.000000000000000000000000000000000000000000000000000000000001223 219.0
TLS1_k127_4087402_1 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000119 191.0
TLS1_k127_4087402_2 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000009694 143.0
TLS1_k127_4087503_0 Transposase, is4 family - - - 0.000007279 57.0
TLS1_k127_4097047_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 2.994e-206 648.0
TLS1_k127_4097047_1 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005104 253.0
TLS1_k127_4097047_2 Radical SAM - - - 0.000000000000000000000000000000000000000004019 156.0
TLS1_k127_4113921_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 334.0
TLS1_k127_4113921_1 Sodium/calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001395 284.0
TLS1_k127_4115105_0 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004077 276.0
TLS1_k127_4115105_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000006967 193.0
TLS1_k127_4115105_2 - - - - 0.000000000000000000000000000000000000000000000000004003 188.0
TLS1_k127_4115105_3 Belongs to the class-I aminoacyl-tRNA synthetase family - - - 0.00000000000000000000000000000000002699 136.0
TLS1_k127_4115105_4 zinc-ribbon domain - - - 0.000000000000000000000000000002254 124.0
TLS1_k127_4116551_0 DHHA1 domain K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 373.0
TLS1_k127_4116551_1 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 364.0
TLS1_k127_4116551_2 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006029 282.0
TLS1_k127_4116551_3 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000002727 224.0
TLS1_k127_4116551_4 transferase activity, transferring glycosyl groups K00752 - 2.4.1.212 0.000000000000000000000000000000000001232 147.0
TLS1_k127_4116551_5 Belongs to the P(II) protein family K04751 - - 0.0000000009961 64.0
TLS1_k127_4131871_0 Peptidase family M23 - - - 0.000000000000000000001073 100.0
TLS1_k127_4131871_2 Enoyl-(Acyl carrier protein) reductase K00034 - 1.1.1.47 0.000000000001558 68.0
TLS1_k127_4132423_0 - - - - 0.0000000000000000000009884 105.0
TLS1_k127_4138720_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 434.0
TLS1_k127_4138720_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 354.0
TLS1_k127_4138720_2 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000002836 241.0
TLS1_k127_4138720_3 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000001595 236.0
TLS1_k127_4138720_4 Amino acid kinase family K06981 - 2.7.4.26 0.000000000000000000000000000000000000000000001219 168.0
TLS1_k127_4165424_0 - - - - 0.00000000000000000000000000000000000000000000000002666 182.0
TLS1_k127_416691_0 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 395.0
TLS1_k127_4181368_0 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 587.0
TLS1_k127_4181368_1 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen - - - 0.00000000000000012 85.0
TLS1_k127_4183704_0 thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000002651 211.0
TLS1_k127_4183704_1 - - - - 0.0000000000000000000000000000000000000006624 152.0
TLS1_k127_4187771_0 - - - - 0.00000000000000000000000000000006064 128.0
TLS1_k127_4187771_2 DDE superfamily endonuclease - - - 0.000000002753 65.0
TLS1_k127_4187771_3 metalloendopeptidase activity K01388,K01394,K01396,K01397,K01402,K01413,K07994,K07999,K08001,K08004,K08005 GO:0000003,GO:0000122,GO:0000302,GO:0000323,GO:0001047,GO:0001067,GO:0001101,GO:0001501,GO:0001503,GO:0001554,GO:0001649,GO:0001666,GO:0001704,GO:0001706,GO:0001775,GO:0001817,GO:0001819,GO:0001958,GO:0001959,GO:0001960,GO:0001961,GO:0001968,GO:0002009,GO:0002011,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002440,GO:0002443,GO:0002444,GO:0002446,GO:0002682,GO:0002683,GO:0002684,GO:0002697,GO:0002775,GO:0002776,GO:0002777,GO:0002778,GO:0002779,GO:0002780,GO:0002790,GO:0002791,GO:0002793,GO:0002831,GO:0003006,GO:0003416,GO:0003417,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005102,GO:0005488,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005764,GO:0005773,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005911,GO:0006355,GO:0006357,GO:0006508,GO:0006518,GO:0006606,GO:0006807,GO:0006810,GO:0006886,GO:0006887,GO:0006913,GO:0006928,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006979,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007369,GO:0007492,GO:0007507,GO:0007548,GO:0007565,GO:0007567,GO:0007568,GO:0008104,GO:0008150,GO:0008152,GO:0008201,GO:0008233,GO:0008236,GO:0008237,GO:0008270,GO:0008284,GO:0008406,GO:0008585,GO:0009056,GO:0009057,GO:0009058,GO:0009605,GO:0009607,GO:0009611,GO:0009612,GO:0009615,GO:0009617,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010243,GO:0010310,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0010727,GO:0010762,GO:0010763,GO:0010941,GO:0010942,GO:0012505,GO:0014070,GO:0014910,GO:0014911,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0016477,GO:0016787,GO:0017038,GO:0017171,GO:0019219,GO:0019221,GO:0019222,GO:0019538,GO:0019730,GO:0019731,GO:0019898,GO:0022411,GO:0022414,GO:0022602,GO:0022603,GO:0022617,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030054,GO:0030141,GO:0030154,GO:0030163,GO:0030198,GO:0030282,GO:0030326,GO:0030334,GO:0030335,GO:0030425,GO:0030574,GO:0031012,GO:0031090,GO:0031214,GO:0031312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0031347,GO:0031348,GO:0031349,GO:0031410,GO:0031667,GO:0031974,GO:0031982,GO:0031983,GO:0031984,GO:0032101,GO:0032102,GO:0032459,GO:0032461,GO:0032479,GO:0032481,GO:0032501,GO:0032502,GO:0032504,GO:0032647,GO:0032727,GO:0032879,GO:0032880,GO:0032940,GO:0032963,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034097,GO:0034405,GO:0034504,GO:0034599,GO:0034613,GO:0034614,GO:0034641,GO:0034774,GO:0035107,GO:0035108,GO:0035113,GO:0035116,GO:0035137,GO:0035265,GO:0035313,GO:0035580,GO:0035690,GO:0035987,GO:0036075,GO:0036230,GO:0036293,GO:0036477,GO:0040007,GO:0040011,GO:0040012,GO:0040017,GO:0042060,GO:0042119,GO:0042127,GO:0042175,GO:0042221,GO:0042406,GO:0042475,GO:0042476,GO:0042481,GO:0042487,GO:0042493,GO:0042581,GO:0042698,GO:0042742,GO:0042886,GO:0042995,GO:0043005,GO:0043043,GO:0043062,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043171,GO:0043200,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043254,GO:0043299,GO:0043312,GO:0043565,GO:0043603,GO:0043604,GO:0043627,GO:0043900,GO:0044057,GO:0044058,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044297,GO:0044319,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044703,GO:0044706,GO:0044849,GO:0044877,GO:0045055,GO:0045088,GO:0045089,GO:0045137,GO:0045184,GO:0045321,GO:0045824,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046545,GO:0046581,GO:0046660,GO:0046872,GO:0046903,GO:0046907,GO:0046914,GO:0048306,GO:0048511,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048589,GO:0048598,GO:0048608,GO:0048609,GO:0048646,GO:0048705,GO:0048729,GO:0048731,GO:0048736,GO:0048856,GO:0048869,GO:0048870,GO:0050678,GO:0050679,GO:0050688,GO:0050691,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050727,GO:0050728,GO:0050750,GO:0050776,GO:0050777,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050829,GO:0050830,GO:0050878,GO:0050896,GO:0050900,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051128,GO:0051130,GO:0051169,GO:0051170,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051193,GO:0051195,GO:0051216,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051240,GO:0051252,GO:0051253,GO:0051254,GO:0051270,GO:0051272,GO:0051641,GO:0051649,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0051896,GO:0051898,GO:0060054,GO:0060135,GO:0060173,GO:0060205,GO:0060255,GO:0060338,GO:0060339,GO:0060340,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060429,GO:0060456,GO:0060759,GO:0060760,GO:0060761,GO:0061448,GO:0061458,GO:0061844,GO:0065007,GO:0065008,GO:0070011,GO:0070013,GO:0070167,GO:0070170,GO:0070173,GO:0070201,GO:0070325,GO:0070482,GO:0070727,GO:0070820,GO:0070887,GO:0071214,GO:0071229,GO:0071230,GO:0071241,GO:0071260,GO:0071310,GO:0071345,GO:0071417,GO:0071495,GO:0071496,GO:0071498,GO:0071702,GO:0071704,GO:0071705,GO:0071731,GO:0071732,GO:0071840,GO:0072359,GO:0072594,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090186,GO:0090187,GO:0090504,GO:0090505,GO:0097159,GO:0097186,GO:0097366,GO:0097367,GO:0097447,GO:0097458,GO:0097708,GO:0098542,GO:0098586,GO:0098827,GO:0098868,GO:0099503,GO:0104004,GO:0120025,GO:0120038,GO:0140096,GO:1900407,GO:1900409,GO:1901163,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902531,GO:1902532,GO:1902679,GO:1902680,GO:1902739,GO:1902741,GO:1902882,GO:1902884,GO:1903201,GO:1903209,GO:1903506,GO:1903507,GO:1903508,GO:1903530,GO:1903532,GO:1904242,GO:1904244,GO:1904724,GO:1904951,GO:2000026,GO:2000027,GO:2000112,GO:2000113,GO:2000145,GO:2000147,GO:2000241,GO:2000377,GO:2000378,GO:2001141 3.4.24.17,3.4.24.22,3.4.24.23,3.4.24.34,3.4.24.65,3.4.24.7 0.00001879 54.0
TLS1_k127_4190669_0 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000005404 195.0
TLS1_k127_4190669_1 - - - - 0.000000000000000000000000000000000000000009129 154.0
TLS1_k127_4191999_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 2.065e-286 897.0
TLS1_k127_4191999_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000003085 224.0
TLS1_k127_4191999_2 Cobalamin B12-binding domain protein K16955,K22491 - - 0.0000000000000000000000000000000000000000000000000000004644 203.0
TLS1_k127_4191999_3 glutamine amidotransferase - - - 0.000000000000007432 77.0
TLS1_k127_4191999_4 Cyclase dehydrase - - - 0.00000003593 61.0
TLS1_k127_4199272_0 ABC-type antimicrobial peptide transport system, ATPase component K02003,K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 312.0
TLS1_k127_4199272_1 extracellular matrix structural constituent - - - 0.0000000000000000000000000000000000000000003804 172.0
TLS1_k127_4210468_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 507.0
TLS1_k127_4219770_0 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000002218 85.0
TLS1_k127_4219770_1 transcriptional - - - 0.0002844 47.0
TLS1_k127_4267055_1 - - - - 0.0000005604 58.0
TLS1_k127_4283260_0 GAF domain - - - 0.000000000000000000002197 109.0
TLS1_k127_4288651_0 helicase activity K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 603.0
TLS1_k127_4288651_1 NurA - - - 0.0000000000000000000000000000000000000000000000000000000002079 209.0
TLS1_k127_4288651_2 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547,K05970 - 3.1.1.53 0.00000000000000000000001785 114.0
TLS1_k127_4288651_3 PFAM SMC domain protein K03546 - - 0.000008098 56.0
TLS1_k127_430831_0 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 557.0
TLS1_k127_430831_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 472.0
TLS1_k127_430831_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000003605 67.0
TLS1_k127_4310190_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 386.0
TLS1_k127_4316236_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 1.23e-241 763.0
TLS1_k127_4316236_1 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000001816 104.0
TLS1_k127_4318250_0 Vinylacetyl-CoA Delta-isomerase K14534 - 4.2.1.120,5.3.3.3 2.339e-280 867.0
TLS1_k127_4318250_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000006188 242.0
TLS1_k127_4318250_2 Transposase DDE domain K07492 - - 0.00000000000000000000000000000002858 131.0
TLS1_k127_4318250_3 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000002431 113.0
TLS1_k127_4318250_4 This gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.0000000000000000001889 92.0
TLS1_k127_4318250_5 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.00000000000001334 76.0
TLS1_k127_4321046_0 TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 344.0
TLS1_k127_4321046_1 - - - - 0.000000000000000000000000000000000000000000000000001554 185.0
TLS1_k127_4321046_2 protein (ATP-grasp superfamily) K07159 - - 0.00000000000000000000000000000000004367 138.0
TLS1_k127_4323532_0 Belongs to the TPP enzyme family K00156,K00158 - 1.2.3.3,1.2.5.1 9.604e-264 825.0
TLS1_k127_4323532_1 PFAM 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001024 274.0
TLS1_k127_4326086_0 PFAM blue (type 1) copper domain protein - - - 0.000000000000000652 88.0
TLS1_k127_435749_0 COG1651 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000007784 224.0
TLS1_k127_435749_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000001606 164.0
TLS1_k127_435749_2 Redoxin - - - 0.00000000000000000000000000000000000003098 144.0
TLS1_k127_438736_0 DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 376.0
TLS1_k127_4398542_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006033 359.0
TLS1_k127_4398542_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.000000000000000000000001217 109.0
TLS1_k127_4405733_0 - - - - 0.0000000000000000000004066 106.0
TLS1_k127_4405975_0 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000004347 220.0
TLS1_k127_4408867_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family - GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016427,GO:0016428,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 308.0
TLS1_k127_4408867_1 Protein involved in ribosomal biogenesis, contains PUA domain K07565 - - 0.0000000000000000000000000003827 120.0
TLS1_k127_4408867_2 tRNA nucleotidyltransferase poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000006674 61.0
TLS1_k127_4412753_0 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000007063 237.0
TLS1_k127_442642_0 FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006862 429.0
TLS1_k127_442642_1 - - - - 0.0000000000000000000000000000000000009578 141.0
TLS1_k127_4428761_0 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000105 205.0
TLS1_k127_4428761_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000007358 74.0
TLS1_k127_4437046_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 382.0
TLS1_k127_4437046_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 293.0
TLS1_k127_4441323_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008041 602.0
TLS1_k127_4441323_1 - - - - 0.0000000000000000000000000001972 117.0
TLS1_k127_4475479_0 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 331.0
TLS1_k127_4475479_1 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000009494 256.0
TLS1_k127_4475479_2 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000003167 130.0
TLS1_k127_4475479_3 - - - - 0.000000000000000000001468 96.0
TLS1_k127_4480827_0 COG0346 Lactoylglutathione lyase and related lyases K15975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 433.0
TLS1_k127_4480827_1 phospholipase Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000002228 221.0
TLS1_k127_4480827_2 Nitroreductase - - - 0.0000000001623 62.0
TLS1_k127_4494162_0 Pirin C-terminal cupin domain K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 389.0
TLS1_k127_4494162_1 Antibiotic biosynthesis monooxygenase K09932 - - 0.000000000000000000000000000000000000000000000001298 182.0
TLS1_k127_4497796_0 Methyltransferase type 11 K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000001339 261.0
TLS1_k127_4497796_1 Major Intrinsic Protein K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001578 257.0
TLS1_k127_4497796_2 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000001241 186.0
TLS1_k127_4497796_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000001848 183.0
TLS1_k127_4512884_0 UbiD family decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 577.0
TLS1_k127_4512884_1 - - - - 0.0000000000000000000000000000000000000000000000008088 182.0
TLS1_k127_4512884_4 TIGRFAM Mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000004421 139.0
TLS1_k127_4512884_5 - - - - 0.0000000000000000006866 90.0
TLS1_k127_4512884_6 Mg2 transporter protein K03284 - - 0.000000007796 57.0
TLS1_k127_4512884_7 Concanavalin A-like lectin/glucanases superfamily - - - 0.0001966 51.0
TLS1_k127_4537469_0 Hemolysin-type calcium-binding - - - 0.00000000000000000000000000009443 126.0
TLS1_k127_4537469_1 - - - - 0.000000000000000000000000001697 126.0
TLS1_k127_4537469_2 Subtilase family K14645 - - 0.00000009953 61.0
TLS1_k127_4559532_0 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 425.0
TLS1_k127_4559532_1 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000000000000001459 145.0
TLS1_k127_4559532_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000001111 103.0
TLS1_k127_4571089_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 546.0
TLS1_k127_4571089_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 447.0
TLS1_k127_4571089_2 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001355 258.0
TLS1_k127_4572297_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01581,K01586,K13747 - 4.1.1.17,4.1.1.20,4.1.1.96 3.631e-200 632.0
TLS1_k127_4572297_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007446 308.0
TLS1_k127_4572297_2 PFAM acylphosphatase K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000000000000006119 104.0
TLS1_k127_4573115_0 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000000000000000000000000000000000003126 158.0
TLS1_k127_4579401_0 Bifunctional nuclease K08999 - - 0.0000000000000000000000000000000000000000000000000000001203 198.0
TLS1_k127_4579401_1 serine-type endopeptidase activity - - - 0.0000000000000000000497 96.0
TLS1_k127_4581010_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005132 542.0
TLS1_k127_4581010_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K03294,K20989 - - 0.0000000000000001041 86.0
TLS1_k127_4581010_2 Phage integrase family - - - 0.000000000001886 75.0
TLS1_k127_4584426_0 PFAM tRNA synthetases class I (C) catalytic domain K01883 - 6.1.1.16 0.0000000000000000002499 93.0
TLS1_k127_4584426_1 IMP dehydrogenase activity - - - 0.0000000000209 65.0
TLS1_k127_4625358_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1296.0
TLS1_k127_4625358_1 Mannosyl-3-phosphoglycerate synthase K05947 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 454.0
TLS1_k127_4625358_2 Archaeal transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004494 347.0
TLS1_k127_4625358_3 - - - - 0.0000000000000000000000000000000001087 143.0
TLS1_k127_4625358_4 Bifunctional nuclease K08999 - - 0.00000000005432 64.0
TLS1_k127_4625397_0 Pyridine nucleotide-disulphide oxidoreductase K03885 GO:0003674,GO:0003824,GO:0003955,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0044237,GO:0045333,GO:0055114 1.6.99.3 0.00000000000000000000000000000000000000000000003471 184.0
TLS1_k127_4631249_0 Histidine kinase A domain protein - - - 0.0000543 48.0
TLS1_k127_4631249_1 response regulator, receiver - - - 0.0005723 46.0
TLS1_k127_4632633_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001472 289.0
TLS1_k127_4632633_1 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000003752 209.0
TLS1_k127_4632633_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01563 - 3.8.1.5 0.000000003651 59.0
TLS1_k127_4633983_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 2.217e-223 706.0
TLS1_k127_4636774_0 Catalyzes the conversion of dihydroorotate to orotate K00226,K00254,K17723,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 347.0
TLS1_k127_4636774_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.000000000000000000000000000000000000000000000000000000000000003237 224.0
TLS1_k127_4636774_2 hydrolase, TatD K07051 - - 0.00000000000000004403 81.0
TLS1_k127_4642186_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 300.0
TLS1_k127_4654870_0 COG1522 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 389.0
TLS1_k127_4654870_1 - - - - 0.0000000000000000000175 94.0
TLS1_k127_4667361_0 Calcineurin-like phosphoesterase - - - 0.0000000000000002747 91.0
TLS1_k127_4668784_0 Radical SAM K06937 - - 0.0 1087.0
TLS1_k127_4668784_1 Belongs to the enoyl-CoA hydratase isomerase family K01715,K15019 - 4.2.1.116,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 426.0
TLS1_k127_4668784_2 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008181 317.0
TLS1_k127_4668784_3 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008757 264.0
TLS1_k127_4668784_4 Conserved hypothetical ATP binding protein K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005612 259.0
TLS1_k127_469802_0 NAD(P)H-quinone oxidoreductase chain 4, chloroplastic K05575 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 449.0
TLS1_k127_469802_1 essential for photochemical activity. FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin. The C-terminus interacts with PsaA B D and helps assemble the protein into the PSI complex. Required for binding of PsaD and PsaE to PSI. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn K02691 - - 0.00000000000000000000000000000000000000000000000006653 177.0
TLS1_k127_469802_2 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic K05576 GO:0003674,GO:0003824,GO:0003954,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008137,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009987,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031976,GO:0031984,GO:0032991,GO:0034357,GO:0042180,GO:0042181,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0050136,GO:0051186,GO:0051188,GO:0055035,GO:0055114,GO:0071704,GO:0098796,GO:1901576,GO:1901661,GO:1901663,GO:1902494 1.6.5.3 0.00000000000000000000000000000000000000003395 153.0
TLS1_k127_4704350_0 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000003513 163.0
TLS1_k127_4704350_1 DUF72 domain containing protein - - - 0.000004839 50.0
TLS1_k127_4706960_0 DNA polymerase IV (family X) K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 368.0
TLS1_k127_4706960_1 Universal stress protein - - - 0.0000000000000000000003473 102.0
TLS1_k127_4706960_2 - - - - 0.00000000001104 68.0
TLS1_k127_4707513_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 441.0
TLS1_k127_4711197_0 NAD(P)H-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004074 253.0
TLS1_k127_4711197_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001286 239.0
TLS1_k127_4720094_0 Carbamoyl-phosphate synthase L chain K18603 - 6.4.1.2,6.4.1.3 1.886e-239 748.0
TLS1_k127_4720094_1 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K18604 - 2.1.3.15,6.4.1.2,6.4.1.3 4.29e-233 730.0
TLS1_k127_4720094_2 - K03646 - - 0.00000000000005738 73.0
TLS1_k127_4720094_3 biotin carboxyl carrier K00627,K01571,K15037,K18605 - 2.3.1.12,4.1.1.3 0.0000000000126 67.0
TLS1_k127_4721604_0 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 464.0
TLS1_k127_4721604_1 Purple acid Phosphatase, N-terminal domain - - - 0.000000000000000000000000008647 123.0
TLS1_k127_472840_0 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000002362 162.0
TLS1_k127_472840_1 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.000000000000000000000000000000000000001712 148.0
TLS1_k127_472840_2 - - - - 0.000000000000000000000001104 106.0
TLS1_k127_472840_3 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000008009 87.0
TLS1_k127_4739868_0 Dual specificity phosphatase, catalytic domain K14165 - 3.1.3.16,3.1.3.48 0.0000000000000000000000000000000000000000000002783 172.0
TLS1_k127_4739899_0 Protein of unknown function, DUF488 - - - 0.0000000000000001163 84.0
TLS1_k127_4744856_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001163 257.0
TLS1_k127_4744856_1 SPTR Transposase, IS4 family protein - - - 0.000000000000000001163 89.0
TLS1_k127_4748175_0 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 476.0
TLS1_k127_4748175_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 409.0
TLS1_k127_4748175_2 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003508 258.0
TLS1_k127_4748175_3 Peptidyl-tRNA hydrolase PTH2 K04794 - 3.1.1.29 0.0000000000000000000000000000000000003546 143.0
TLS1_k127_4748175_4 Zn-ribbon RNA-binding protein with a function in translation K07580 - - 0.000000000000000000000000000004725 119.0
TLS1_k127_4748175_5 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.00000000000000000000000000006312 119.0
TLS1_k127_4748175_6 - - - - 0.0000000000000000000003886 96.0
TLS1_k127_4748175_7 - - - - 0.0005061 44.0
TLS1_k127_4758517_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 561.0
TLS1_k127_4758517_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 382.0
TLS1_k127_4758517_2 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) K05967 - - 0.000000000000000000000000000000000000000000000000000000000001648 214.0
TLS1_k127_4758517_3 - - - - 0.00000000000000000000004964 102.0
TLS1_k127_4766298_0 geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 531.0
TLS1_k127_4766298_1 Belongs to the complex I 20 kDa subunit family K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000002432 207.0
TLS1_k127_4766298_2 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000008883 205.0
TLS1_k127_4766298_3 AhpC/TSA antioxidant enzyme K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000001081 173.0
TLS1_k127_4766298_5 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000001712 140.0
TLS1_k127_4766298_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000000000000000000000000000000001083 134.0
TLS1_k127_4767535_0 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008786 273.0
TLS1_k127_4772251_0 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 418.0
TLS1_k127_4772251_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 406.0
TLS1_k127_4772251_2 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.000000000000000001549 88.0
TLS1_k127_4773354_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 551.0
TLS1_k127_4773354_1 Chorismate mutase type II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 482.0
TLS1_k127_4773354_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000005522 268.0
TLS1_k127_4773354_3 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000004965 54.0
TLS1_k127_4773577_0 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003325 241.0
TLS1_k127_4775733_0 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 1.657e-210 665.0
TLS1_k127_4777438_0 GHMP kinases N terminal domain K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 291.0
TLS1_k127_4777438_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000788 206.0
TLS1_k127_4777438_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000006408 114.0
TLS1_k127_4795701_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 510.0
TLS1_k127_4795701_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00002032 49.0
TLS1_k127_480392_0 PFAM S-layer - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 365.0
TLS1_k127_480392_1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000000001248 224.0
TLS1_k127_480392_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000001353 216.0
TLS1_k127_480392_3 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 0.00000000000000000000000000000000008694 134.0
TLS1_k127_4833759_0 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009444 369.0
TLS1_k127_4833759_1 cytochrome-c peroxidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000003767 228.0
TLS1_k127_4833759_2 NUDIX domain - - - 0.0000000000000000000000000002226 120.0
TLS1_k127_4867370_0 Methionine synthase K00548 - 2.1.1.13 0.0 1143.0
TLS1_k127_4867370_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000003068 201.0
TLS1_k127_4874952_0 RNA-metabolising metallo-beta-lactamase K07041 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 606.0
TLS1_k127_4887706_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 503.0
TLS1_k127_4887706_1 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000997 107.0
TLS1_k127_4913431_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 501.0
TLS1_k127_4913431_1 ATPase family associated with various cellular activities (AAA) K04800 - - 0.00000000000000000000000000000000000000000000003612 172.0
TLS1_k127_4917810_0 Sodium/calcium exchanger protein K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001228 256.0
TLS1_k127_4923679_0 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 414.0
TLS1_k127_4923679_1 Lysine biosynthesis K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 378.0
TLS1_k127_4923679_2 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 340.0
TLS1_k127_4923679_3 lysine biosynthesis protein LysW K05826 - - 0.00000000000000000007758 90.0
TLS1_k127_4937031_0 Anticodon-binding domain of tRNA K01873 - 6.1.1.9 9.152e-263 817.0
TLS1_k127_4937031_1 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 321.0
TLS1_k127_4942771_0 Belongs to the MCM family K10726 - - 0.000000000000000000000000000000000000000000000000000003378 193.0
TLS1_k127_4942771_1 - - - - 0.0000000000000000000000000000000001093 135.0
TLS1_k127_4942771_2 transcription factor (CBF NF-Y) - - - 0.0000000000000000002306 89.0
TLS1_k127_4942771_3 - - - - 0.00000000000004579 76.0
TLS1_k127_4944806_0 - - - - 0.00000000000000000000000000000000001196 145.0
TLS1_k127_4944806_1 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091,K01838,K07025 - 3.1.3.18,5.4.2.6 0.00000000000000000000000000002564 123.0
TLS1_k127_4957548_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 1.619e-249 792.0
TLS1_k127_4957548_1 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 499.0
TLS1_k127_4963124_0 Galactose oxidase, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 328.0
TLS1_k127_4979728_0 Belongs to the MCM family K10726 - - 0.0 1054.0
TLS1_k127_4979728_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 486.0
TLS1_k127_4979728_2 GINS complex protein K09723 - - 0.000000000000000000000000000000000000000000000000002297 188.0
TLS1_k127_4979728_3 Domain of unknown function (DUF1802) - - - 0.0000000000000000001033 95.0
TLS1_k127_4986193_0 Isocitrate isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 534.0
TLS1_k127_4986193_1 - - - - 0.000000000000000000000000000000000000000000000000000000000002103 214.0
TLS1_k127_4986193_2 Methyltransferase small domain K02493 - 2.1.1.297 0.000000000000000000000000000000000000002906 151.0
TLS1_k127_4995821_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005554 370.0
TLS1_k127_5000047_0 Sodium:neurotransmitter symporter family K03308 - - 0.000000000000000000000000000000000000000000000000000000000002894 219.0
TLS1_k127_5000047_1 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000002636 128.0
TLS1_k127_5000788_0 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 306.0
TLS1_k127_5000788_1 transcriptional - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 313.0
TLS1_k127_5000788_2 conserved protein implicated in secretion - - - 0.0000000000000000000000000000000002473 141.0
TLS1_k127_5004089_0 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases K05710 - - 0.000000000000000000000000000004424 123.0
TLS1_k127_5004089_1 RNA-binding protein contains TRAM domain - - - 0.0000000000000000000107 97.0
TLS1_k127_5012779_0 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000000000000000001459 133.0
TLS1_k127_5012779_1 cell adhesion involved in biofilm formation - - - 0.0000000000007854 80.0
TLS1_k127_5012779_2 response regulator, receiver - - - 0.000000000006159 71.0
TLS1_k127_5013442_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 394.0
TLS1_k127_5013442_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 306.0
TLS1_k127_5013442_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000002968 212.0
TLS1_k127_5018728_0 DEAD DEAH box helicase K06877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 514.0
TLS1_k127_5034228_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 469.0
TLS1_k127_5034228_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000001869 81.0
TLS1_k127_5036282_0 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000003346 244.0
TLS1_k127_5036282_1 ATP synthase subunit C K02124 - - 0.000000000000000000000000004073 113.0
TLS1_k127_5036282_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000000000001884 72.0
TLS1_k127_5036282_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.0004487 49.0
TLS1_k127_5037756_0 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000003094 139.0
TLS1_k127_5037756_1 Heavy-metal-associated domain K01533 - 3.6.3.4 0.0000000000002116 70.0
TLS1_k127_5037756_2 Calcineurin-like phosphoesterase - - - 0.0000000000004505 81.0
TLS1_k127_5045644_0 - - - - 0.00000000001531 74.0
TLS1_k127_5059213_0 CBS domain K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006514 246.0
TLS1_k127_5059213_1 - - - - 0.000000000000000007646 88.0
TLS1_k127_5061901_1 with the alpha beta hydrolase fold - - - 0.0009628 51.0
TLS1_k127_507498_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 2.111e-244 770.0
TLS1_k127_507498_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0006693 43.0
TLS1_k127_5130006_0 MGS-like domain K01955 - 6.3.5.5 0.0 1459.0
TLS1_k127_5130006_1 Calcineurin-like phosphoesterase K06953 - - 0.00000000000000000163 88.0
TLS1_k127_5218007_0 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 426.0
TLS1_k127_525306_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 350.0
TLS1_k127_525306_1 glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006378 271.0
TLS1_k127_5308749_0 - - - - 0.00000000000000004489 87.0
TLS1_k127_5308749_1 Transcriptional regulator - - - 0.000008596 49.0
TLS1_k127_5329148_0 aldo-keto reductase (NADP) activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 356.0
TLS1_k127_5329148_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 352.0
TLS1_k127_5329148_3 response regulator, receiver - - - 0.000000000009785 66.0
TLS1_k127_5414329_0 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001241 263.0
TLS1_k127_5414329_1 Ferritin-like domain - - - 0.000000000000000000000000000000000000000000000000000001 195.0
TLS1_k127_5418037_0 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000007343 249.0
TLS1_k127_5442395_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 535.0
TLS1_k127_5442395_1 resolvase K14060 - - 0.00000000000000000004018 91.0
TLS1_k127_5469516_0 Alpha beta hydrolase - - - 0.000000000002674 78.0
TLS1_k127_5474980_0 Photosystem II CP47 chlorophyll apoprotein K02704 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010207,GO:0010287,GO:0015979,GO:0016020,GO:0016043,GO:0019684,GO:0022607,GO:0031976,GO:0031984,GO:0034357,GO:0034622,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0065003,GO:0071840 - 0.000000000000000001892 85.0
TLS1_k127_5474980_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963,K02696 - 2.1.3.15,6.4.1.2 0.000000007125 58.0
TLS1_k127_5491361_0 PFAM Aldehyde dehydrogenase K00135,K18601 - 1.2.1.16,1.2.1.20,1.2.1.79 3.409e-212 667.0
TLS1_k127_5491361_1 PFAM Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000008106 242.0
TLS1_k127_5491361_2 IMP dehydrogenase activity - - - 0.000000000009319 66.0
TLS1_k127_5493923_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004239 369.0
TLS1_k127_5493923_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000002329 201.0
TLS1_k127_5510086_0 Purple acid Phosphatase, N-terminal domain - - - 0.00000000000000000000005882 110.0
TLS1_k127_5513250_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 4.825e-205 642.0
TLS1_k127_5513250_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 592.0
TLS1_k127_5513250_2 Carbon-nitrogen hydrolase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000537 298.0
TLS1_k127_5513250_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000007105 243.0
TLS1_k127_5513250_4 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000009714 192.0
TLS1_k127_5513250_5 - - - - 0.0000000000000000000003454 98.0
TLS1_k127_5513380_0 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001032 267.0
TLS1_k127_5513380_1 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000003562 216.0
TLS1_k127_5513380_2 Belongs to the archaeal adenylate kinase family K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000004826 192.0
TLS1_k127_5516885_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009376 593.0
TLS1_k127_5516885_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000004231 128.0
TLS1_k127_5517603_0 TIGRFAM glutamine synthetase, type I K01915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.1.2 6.613e-195 620.0
TLS1_k127_5518628_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002119 258.0
TLS1_k127_5523703_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 336.0
TLS1_k127_5527020_0 RNA-metabolising metallo-beta-lactamase K07041 - - 0.0 1020.0
TLS1_k127_5527020_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 464.0
TLS1_k127_5527020_2 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 423.0
TLS1_k127_5527020_3 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000001784 173.0
TLS1_k127_5535209_0 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000002629 176.0
TLS1_k127_5546871_0 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 546.0
TLS1_k127_5546871_1 Transcription elongation factor - - - 0.00000000000000000000000000000000000000003713 157.0
TLS1_k127_5546871_2 metal-dependent protease of the PAD1 JAB1 superfamily K21140 - 3.13.1.6 0.00000000000000000002348 95.0
TLS1_k127_5554953_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 405.0
TLS1_k127_5554953_1 ABC-type transport system, periplasmic component surface lipoprotein K02058,K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 391.0
TLS1_k127_5556895_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K01953,K06927 - 6.3.1.14,6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006691 555.0
TLS1_k127_5556895_1 COG1335 Amidases related to nicotinamidase K09020 - 3.5.1.110 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 299.0
TLS1_k127_5557417_0 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 617.0
TLS1_k127_5557417_1 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.0000000000000000000000000000000000000001099 153.0
TLS1_k127_5557417_2 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000003511 145.0
TLS1_k127_5563336_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000009328 203.0
TLS1_k127_5574769_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.000000000000000000000000001134 117.0
TLS1_k127_5574769_1 Universal stress protein - - - 0.000000000000000000007041 98.0
TLS1_k127_5574769_2 CHRD domain - - - 0.00000000000006886 79.0
TLS1_k127_5575402_0 ribosomal protein L3 K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 456.0
TLS1_k127_5575402_1 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 371.0
TLS1_k127_5575402_2 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 328.0
TLS1_k127_5575402_3 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 310.0
TLS1_k127_5575402_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000706 278.0
TLS1_k127_5575402_5 Ribosomal protein L4 K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005273 254.0
TLS1_k127_5575402_6 Putative RNA methyltransferase K09142 - - 0.0000000000000000000000000000000000000000000000000000000000008115 220.0
TLS1_k127_5575402_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000006992 151.0
TLS1_k127_5575402_8 Domain of unknown function (DUF371) K09738 - - 0.0000000000000000000000000000000000001475 145.0
TLS1_k127_5575402_9 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000001395 105.0
TLS1_k127_5575793_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007389 396.0
TLS1_k127_5575793_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 283.0
TLS1_k127_5576601_0 NurA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 304.0
TLS1_k127_5576601_1 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000008259 100.0
TLS1_k127_5583420_0 - - - - 0.00000000000000000000003491 108.0
TLS1_k127_5583420_1 Dodecin K09165 - - 0.000000001482 61.0
TLS1_k127_5583671_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 374.0
TLS1_k127_5583671_1 - - - - 0.0000000000000001052 92.0
TLS1_k127_5596193_0 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006168 257.0
TLS1_k127_5596193_1 Radical SAM K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000008663 192.0
TLS1_k127_5599244_0 Iron-containing redox enzyme K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000003123 187.0
TLS1_k127_5599244_1 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000001081 173.0
TLS1_k127_5605583_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003589 432.0
TLS1_k127_5605583_1 Diphthamide synthase K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000008157 237.0
TLS1_k127_5605583_2 Transcriptional regulator - - - 0.0000002424 55.0
TLS1_k127_5658692_0 Luciferase-like monooxygenase K14728 - - 2.247e-212 662.0
TLS1_k127_5658692_1 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 537.0
TLS1_k127_5658692_2 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 362.0
TLS1_k127_5658692_3 Transcriptional regulator K07108 - - 0.000000000000000000000000000000000000000000000000000000006302 200.0
TLS1_k127_5658692_4 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000000000000000000000000000000151 181.0
TLS1_k127_5661805_0 - - - - 0.0000000000000000003021 89.0
TLS1_k127_5664173_0 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000000000000000006356 204.0
TLS1_k127_5664173_1 Chondroitinase B - - - 0.0000000000000000000000000000000001573 152.0
TLS1_k127_5664173_2 Concanavalin A-like lectin/glucanases superfamily - - - 0.0000000000876 75.0
TLS1_k127_5671017_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 561.0
TLS1_k127_5671017_1 F420-0:Gamma-glutamyl ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 291.0
TLS1_k127_5693350_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.105e-282 874.0
TLS1_k127_5693350_1 Alpha beta hydrolase K01066,K14731 - 3.1.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 465.0
TLS1_k127_5693350_2 KR domain - - - 0.0000000000000000000000000000000000000000000000001095 185.0
TLS1_k127_5693350_4 Dodecin K09165 - - 0.000000001078 61.0
TLS1_k127_5700509_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.000000000000000000000000000000000000000000000000000000000000001566 230.0
TLS1_k127_5700509_1 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000000000000001811 91.0
TLS1_k127_5706823_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000645 162.0
TLS1_k127_5706823_1 N-terminal domain of oxidoreductase K07119 - - 0.0000000000001772 72.0
TLS1_k127_5715274_0 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031976,GO:0031984,GO:0032991,GO:0033177,GO:0034220,GO:0034357,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055035,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000002269 150.0
TLS1_k127_5715274_1 - - - - 0.0000000000000000000007793 97.0
TLS1_k127_5715798_0 Radical SAM - - - 1.137e-320 984.0
TLS1_k127_5715798_1 oxidoreductase FAD NAD(P)-binding K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008252 469.0
TLS1_k127_5715798_2 Glycosyl transferase family 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 456.0
TLS1_k127_5715798_3 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 291.0
TLS1_k127_5715798_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000001829 220.0
TLS1_k127_5715798_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function - - - 0.00000000000000000000000000000000000000000000000006588 186.0
TLS1_k127_5715798_6 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000016 168.0
TLS1_k127_5715798_7 - - - - 0.0000000000000000000000000000000000001872 143.0
TLS1_k127_5715798_8 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000005112 87.0
TLS1_k127_574398_0 PAC2 family K06869 - - 0.00000000000000000000000000000004697 130.0
TLS1_k127_5763917_0 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.00000000000000000000000000000000000000000000000000000000000001693 219.0
TLS1_k127_5764350_0 DNA polymerase K02319 - 2.7.7.7 0.0 1161.0
TLS1_k127_5764350_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008757 264.0
TLS1_k127_5772606_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 296.0
TLS1_k127_5772606_1 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000009016 218.0
TLS1_k127_5794413_0 Dihydrolipoyl dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000006726 213.0
TLS1_k127_5811171_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.0000000000000000000000000000000000000000000000005822 188.0
TLS1_k127_5826298_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.523e-217 683.0
TLS1_k127_5826298_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 464.0
TLS1_k127_5826298_2 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000000000000000009597 203.0
TLS1_k127_5826298_3 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000005938 191.0
TLS1_k127_5826298_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000009405 183.0
TLS1_k127_5826298_5 ribosomal protein K02976 - - 0.0000000000000000000000000000000000000000000006325 168.0
TLS1_k127_5834106_0 TIGRFAM phosphodiesterase, MJ0936 family K07095 - - 0.0000000000000000007824 88.0
TLS1_k127_5835872_0 Sodium:sulfate symporter transmembrane region K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 496.0
TLS1_k127_5857396_0 Photosystem II CP47 chlorophyll apoprotein K02704 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010207,GO:0010287,GO:0015979,GO:0016020,GO:0016043,GO:0019684,GO:0022607,GO:0031976,GO:0031984,GO:0034357,GO:0034622,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0065003,GO:0071840 - 0.0 1057.0
TLS1_k127_5857396_1 Cytochrome b6 K02635,K02704 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 446.0
TLS1_k127_5857396_2 cytochrome b6 K02635,K02704 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 334.0
TLS1_k127_5857396_3 One of the components of the core complex of photosystem II (PSII), required for its stability and or assembly. PSII is a light-driven water plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation K02709 - - 0.0000000000000000000000000000000000007536 140.0
TLS1_k127_5857396_4 May play a role in photosystem I and II biogenesis K02715 - - 0.0000000000000000000165 90.0
TLS1_k127_5857396_5 One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light- driven water plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation K02704 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0009987,GO:0010207,GO:0010287,GO:0015979,GO:0016020,GO:0016043,GO:0019684,GO:0022607,GO:0031976,GO:0031984,GO:0034357,GO:0034622,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0065003,GO:0071840 - 0.000000000000277 69.0
TLS1_k127_58699_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 410.0
TLS1_k127_58699_1 RNA-binding protein contains TRAM domain - - - 0.0000000000000000005736 89.0
TLS1_k127_590538_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 426.0
TLS1_k127_590538_1 Siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001194 276.0
TLS1_k127_5933924_0 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 520.0
TLS1_k127_5933924_1 Archaeal ammonia monooxygenase subunit A (AmoA) K10944 - 1.14.18.3,1.14.99.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 417.0
TLS1_k127_5933924_2 Monooxygenase subunit B protein K10945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007717 248.0
TLS1_k127_5933924_3 - - - - 0.000000000000000000000000000000000000000007113 155.0
TLS1_k127_5933924_4 - - - - 0.000000000000000000000000000000000000001309 148.0
TLS1_k127_5933924_5 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000007692 109.0
TLS1_k127_5959952_0 CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002279 233.0
TLS1_k127_5984982_0 Transcriptional regulator - - - 0.000000496 55.0
TLS1_k127_6034139_0 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.21.7 0.0000000000000000000000000000000000000000000000000000000000007198 217.0
TLS1_k127_6052344_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 573.0
TLS1_k127_6052344_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 330.0
TLS1_k127_6052344_2 Protein of unknown function (DUF763) K09003 - - 0.000000000000000000000000000000000000000000000001029 180.0
TLS1_k127_6052344_3 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000001139 150.0
TLS1_k127_6052344_4 Protein of unknown function (DUF763) K09003 - - 0.000000000000000000000000000000009565 130.0
TLS1_k127_6052344_5 - - - - 0.0000000000000000000000000006391 116.0
TLS1_k127_6052344_6 - - - - 0.0000000000000000801 83.0
TLS1_k127_6052344_8 - - - - 0.000000000001341 68.0
TLS1_k127_6070454_0 GXGXG motif K22082 - 2.1.1.21 0.000004728 58.0
TLS1_k127_6088522_0 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 421.0
TLS1_k127_6088522_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000002633 148.0
TLS1_k127_6088522_2 Deoxyhypusine synthase K00809 - 2.5.1.46 0.0000000001664 63.0
TLS1_k127_6090902_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008773 276.0
TLS1_k127_6090902_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000215 44.0
TLS1_k127_6115603_0 hydrolase (HAD superfamily) K01091,K01560,K01561,K07025 - 3.1.3.18,3.8.1.2,3.8.1.3 0.00000000000000000000000000000000000000000000000000000000003533 213.0
TLS1_k127_6115603_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000006782 139.0
TLS1_k127_6115603_2 Domain of unknown function (DUF1297) K06863 - 6.3.4.23 0.00000000000000000008944 89.0
TLS1_k127_6117300_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K00313 - - 5.23e-248 779.0
TLS1_k127_6117300_1 Electron transfer flavoprotein domain K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005693 508.0
TLS1_k127_6117300_2 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 387.0
TLS1_k127_6117300_3 - - - - 0.00000000001826 65.0
TLS1_k127_6117300_4 PQ loop repeat K15383 - - 0.0000000008037 64.0
TLS1_k127_6126508_0 UV-endonuclease UvdE - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 324.0
TLS1_k127_6126508_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000001685 235.0
TLS1_k127_6126508_2 Transcriptional regulatory protein, C terminal - - - 0.00000002043 58.0
TLS1_k127_6128034_0 Heat shock 70 kDa protein K04043 - - 2.522e-311 963.0
TLS1_k127_6128034_1 DnaJ central domain K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 510.0
TLS1_k127_6128034_2 Translation initiation factor K03238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003256 248.0
TLS1_k127_6128034_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000000001097 177.0
TLS1_k127_6128034_4 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000000002998 164.0
TLS1_k127_6128411_0 Sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 294.0
TLS1_k127_6128411_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000000000000000000001716 123.0
TLS1_k127_6129682_0 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000005671 173.0
TLS1_k127_6129896_0 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 599.0
TLS1_k127_6139812_0 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 473.0
TLS1_k127_6139812_1 resolvase K14060 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 302.0
TLS1_k127_6139812_2 Aminotransferase class I and II K00639,K00652,K01906 - 2.3.1.29,2.3.1.47,6.2.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000008612 274.0
TLS1_k127_6139812_3 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000000000000001797 194.0
TLS1_k127_6139812_4 - - - - 0.0000000000000000000000000001187 119.0
TLS1_k127_6139812_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.00001207 49.0
TLS1_k127_6148825_0 DNA-directed RNA polymerase K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0030880,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 516.0
TLS1_k127_6148825_1 30S ribosomal protein S2, chloroplastic K02967 GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0031974,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0098798,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 286.0
TLS1_k127_6160998_0 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.000000000000000000000000000000005078 129.0
TLS1_k127_6160998_1 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.000000000000005082 76.0
TLS1_k127_6160998_2 - - - - 0.000000000000009825 78.0
TLS1_k127_6160998_3 Acetyltransferase (GNAT) domain - - - 0.00000000000004113 72.0
TLS1_k127_6167073_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007422 347.0
TLS1_k127_6167073_1 Belongs to the universal stress protein A family - - - 0.0004093 49.0
TLS1_k127_6168486_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 1.208e-303 942.0
TLS1_k127_6168486_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 7.654e-215 679.0
TLS1_k127_6168486_2 NADH ubiquinone oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000002295 214.0
TLS1_k127_6168486_3 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000000000000000001766 169.0
TLS1_k127_6168486_4 Transcriptional regulator - - - 0.00000000000002202 76.0
TLS1_k127_6170132_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 614.0
TLS1_k127_6170132_1 TIGRFAM 2-methylcitrate synthase citrate synthase II K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 572.0
TLS1_k127_6170132_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 361.0
TLS1_k127_6170132_3 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 285.0
TLS1_k127_6170132_4 PUA domain K07575 - - 0.000000000000000000000000000000000000633 144.0
TLS1_k127_6170132_5 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00005127 46.0
TLS1_k127_6231624_0 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 301.0
TLS1_k127_6231624_1 Large family of predicted nucleotide-binding domains K06865 - - 0.00000000000000000000000000000000000000000000000000000000000000002349 228.0
TLS1_k127_6240421_0 TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 475.0
TLS1_k127_6240421_1 - - - - 0.0000000000000000000000000000000003704 134.0
TLS1_k127_6240421_2 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.0000005617 58.0
TLS1_k127_6245981_0 - - - - 0.0000000000000000000000000000000009546 132.0
TLS1_k127_6245981_1 Transcriptional regulator - - - 0.00000000000001752 76.0
TLS1_k127_6245981_2 Matrix metallopeptidase 19 K07763,K07998 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004252,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008237,GO:0009987,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022411,GO:0022617,GO:0030198,GO:0031012,GO:0043062,GO:0043170,GO:0044238,GO:0044421,GO:0070011,GO:0071704,GO:0071840,GO:0140096,GO:1901564 3.4.24.80 0.000001817 57.0
TLS1_k127_6245981_3 ligase activity K00666,K03892 - - 0.00001077 50.0
TLS1_k127_6251399_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 595.0
TLS1_k127_6251399_1 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 398.0
TLS1_k127_6251399_2 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.0000000000000000000000000000000000000000000000000000000009462 201.0
TLS1_k127_6251399_3 helix_turn_helix ASNC type - - - 0.0000000000000000425 83.0
TLS1_k127_6251789_0 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 396.0
TLS1_k127_6251789_1 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 311.0
TLS1_k127_6252515_0 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 549.0
TLS1_k127_6252515_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002614 522.0
TLS1_k127_626604_0 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003351 258.0
TLS1_k127_626604_1 RNA binding K07581 - - 0.000000000000000001097 92.0
TLS1_k127_6272595_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006434 586.0
TLS1_k127_6300838_0 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 467.0
TLS1_k127_6300838_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 364.0
TLS1_k127_6300838_2 fumarate reductase flavoprotein K00239 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 296.0
TLS1_k127_6300838_3 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00241 - - 0.000000000000000000000000000000000000000000000000000000000000000008403 228.0
TLS1_k127_6300838_4 Protein of unknown function (DUF354) K09726 - - 0.000000000000000000000000000000000000000000000000000001304 201.0
TLS1_k127_6300838_5 Iron-sulfur cluster assembly protein - - - 0.000000000000000000000000000000000000000000003536 166.0
TLS1_k127_6300838_6 Succinate dehydrogenase/Fumarate reductase transmembrane subunit K00242 - - 0.0000000000000000000000000000000000000002355 153.0
TLS1_k127_634122_0 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007464 332.0
TLS1_k127_634122_1 - - - - 0.0000000000000000000000000007713 121.0
TLS1_k127_634122_2 - - - - 0.0000000000000000000009754 100.0
TLS1_k127_6371159_0 Cysteine synthase K12339 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 529.0
TLS1_k127_6371159_1 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000003745 259.0
TLS1_k127_6371159_2 redox protein, regulator of disulfide bond formation - - - 0.000000000000000000000000000003046 121.0
TLS1_k127_6371159_3 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000000004511 64.0
TLS1_k127_6371737_0 - - - - 0.000000000000000000000000000000000000000000000000000000001497 205.0
TLS1_k127_6371737_1 - - - - 0.0000000000000000000000000000000000000000007286 163.0
TLS1_k127_6374973_0 synthetase (class II) K01880 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 552.0
TLS1_k127_6374973_1 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000000000000000000000000174 142.0
TLS1_k127_6377601_0 - - - - 0.000000000000000000000000000000001165 134.0
TLS1_k127_6377601_1 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000000000002236 112.0
TLS1_k127_6377601_2 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000000001973 91.0
TLS1_k127_6377601_3 - - - - 0.00000000004234 68.0
TLS1_k127_6377601_4 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000003989 49.0
TLS1_k127_6377601_5 Anthranilate phosphoribosyltransferase K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0031967,GO:0031975,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.000005122 53.0
TLS1_k127_6403067_0 SnoaL-like domain - - - 0.000000000000000000000008611 105.0
TLS1_k127_6403067_1 membrane - - - 0.000001245 57.0
TLS1_k127_644125_0 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000001392 165.0
TLS1_k127_6509184_0 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 356.0
TLS1_k127_6509184_1 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001083 258.0
TLS1_k127_6515863_0 Protein of unknown function DUF72 - - - 0.0000000000000009189 80.0
TLS1_k127_6517692_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 431.0
TLS1_k127_6517692_1 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000004632 254.0
TLS1_k127_6521557_0 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 297.0
TLS1_k127_6521557_1 ParB-like nuclease domain K03497 - - 0.0000000000000004231 81.0
TLS1_k127_6521557_2 PFAM response regulator receiver - - - 0.00000000004313 68.0
TLS1_k127_6522629_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 335.0
TLS1_k127_6522629_1 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005669 267.0
TLS1_k127_6522629_2 Participates in transcription termination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000003106 231.0
TLS1_k127_6525774_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 445.0
TLS1_k127_6525774_1 - - - - 0.000000000000000000003043 98.0
TLS1_k127_6525774_2 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000006291 61.0
TLS1_k127_6527621_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 3.572e-267 841.0
TLS1_k127_6527621_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004299 557.0
TLS1_k127_6527621_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000005575 143.0
TLS1_k127_6533406_0 response regulator, receiver - - - 0.00000000000000000000000002606 112.0
TLS1_k127_6533406_1 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.00000000006405 64.0
TLS1_k127_6533908_0 segregation and condensation protein K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000007716 231.0
TLS1_k127_6533908_1 chromosome segregation and condensation protein ScpA K05896 - - 0.00000000000000000000000000000000000000000000000000000000002071 213.0
TLS1_k127_6533908_2 Ribosomal protein S8e K02995 - - 0.00000000000000000000000000000000000000000003001 164.0
TLS1_k127_6533908_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03014 - - 0.0000000000000000000000000004287 120.0
TLS1_k127_6533908_4 Cyclophilin-like K09143 - - 0.000000000000000000003841 97.0
TLS1_k127_6533908_5 S25 ribosomal protein K02975 - - 0.000000000000001895 78.0
TLS1_k127_6537108_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001308 262.0
TLS1_k127_6538428_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006129 357.0
TLS1_k127_6538428_1 - - - - 0.0000000000000000001488 101.0
TLS1_k127_6538428_3 Acetyltransferase (GNAT) domain - - - 0.000001373 57.0
TLS1_k127_6558312_0 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001626 261.0
TLS1_k127_6558312_1 - - - - 0.0000000000000000000000007226 111.0
TLS1_k127_6558312_2 OsmC-like protein - - - 0.000000000000000000003164 98.0
TLS1_k127_6558529_0 ester cyclase - - - 0.0000000000000000000000000000000000000000000000007027 181.0
TLS1_k127_6558529_1 - - - - 0.00000002794 61.0
TLS1_k127_6561959_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000003162 79.0
TLS1_k127_6561959_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0002559 44.0
TLS1_k127_6609059_0 PFAM Aminotransferase class I and II K00817,K04720 - 2.6.1.9,4.1.1.81 0.0000000000000000000000000000000008 135.0
TLS1_k127_6609059_1 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.0000000001558 63.0
TLS1_k127_6609059_2 ATP-independent chaperone mediated protein folding - - - 0.00000002463 58.0
TLS1_k127_6642245_0 PFAM Integrase core domain K07497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 302.0
TLS1_k127_6642245_1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000003586 161.0
TLS1_k127_6656294_0 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000008161 166.0
TLS1_k127_6720835_0 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 310.0
TLS1_k127_6720835_1 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0050897,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.19 0.00000000000000000000000000000000000000000000000002521 179.0
TLS1_k127_6720835_2 ABC transporter K01990 - - 0.0000000003042 64.0
TLS1_k127_6744341_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 449.0
TLS1_k127_6744341_1 GTPase of unknown function C-terminal K06942 - - 0.0000000000000000000000000000000000000000000000000000000000001774 215.0
TLS1_k127_6744341_2 - - - - 0.00000000000000000000000000001374 120.0
TLS1_k127_6769911_0 Glycosyl transferase family group 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 454.0
TLS1_k127_6837381_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000001434 251.0
TLS1_k127_6837381_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000005989 216.0
TLS1_k127_6837381_2 PBS lyase HEAT-like repeat K06072 - 1.14.99.29 0.000000000000000000000000000000000000000000000000000000002852 203.0
TLS1_k127_6889281_0 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000000000000000003911 202.0
TLS1_k127_6889281_1 Zinc finger, C2H2 type - - - 0.0000000000006812 72.0
TLS1_k127_692484_0 Belongs to the PdxS SNZ family K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000005494 176.0
TLS1_k127_692484_1 - - - - 0.000000000000001145 78.0
TLS1_k127_7053614_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 397.0
TLS1_k127_7055542_0 Belongs to the arginase family K01476 - 3.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 396.0
TLS1_k127_7055542_1 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 306.0
TLS1_k127_7055542_2 regulatory protein, arsR - - - 0.0000000000000000000000000001047 117.0
TLS1_k127_7055542_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000004072 78.0
TLS1_k127_7102214_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 8.719e-229 714.0
TLS1_k127_7103893_0 Purple acid Phosphatase, N-terminal domain - - - 0.0000000000000000000000000000056 136.0
TLS1_k127_7121353_0 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 398.0
TLS1_k127_7124146_0 NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05579 GO:0003674,GO:0003824,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009532,GO:0009534,GO:0009535,GO:0009536,GO:0009570,GO:0009579,GO:0016020,GO:0016491,GO:0016651,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0055114 1.6.5.3 2.64e-246 762.0
TLS1_k127_7124146_1 NAD(P)H-quinone oxidoreductase subunit 5, chloroplastic K05577 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 467.0
TLS1_k127_7124146_2 NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05580 GO:0003674,GO:0003824,GO:0003959,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0009987,GO:0015979,GO:0016020,GO:0016491,GO:0016651,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007004 346.0
TLS1_k127_7124146_3 NDH shuttles electrons from NAD(P)H plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient K05572 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0015979,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0055114,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 314.0
TLS1_k127_7124146_4 NAD(P)H-quinone oxidoreductase subunit 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 306.0
TLS1_k127_7124146_5 NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic K05578 GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0044237 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 290.0
TLS1_k127_7124146_6 30S ribosomal protein S15 K02956 GO:0000312,GO:0000313,GO:0000314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0009507,GO:0009532,GO:0009536,GO:0009547,GO:0009570,GO:0015935,GO:0032991,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000005177 135.0
TLS1_k127_7124146_7 Carboxyl transferase domain K01963,K02696 - 2.1.3.15,6.4.1.2 0.000000000000009979 83.0
TLS1_k127_7141216_0 NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 424.0
TLS1_k127_7142686_0 PFAM aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 549.0
TLS1_k127_7142686_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 396.0
TLS1_k127_7142686_2 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 390.0
TLS1_k127_7142686_3 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 331.0
TLS1_k127_7142686_4 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 288.0
TLS1_k127_7142686_5 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.000000121 62.0
TLS1_k127_7152039_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 578.0
TLS1_k127_7152039_1 Phenylalanyl-tRNA synthetase alpha subunit K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 519.0
TLS1_k127_715435_0 AAA domain (Cdc48 subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007153 608.0
TLS1_k127_715435_1 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000554 454.0
TLS1_k127_715435_2 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002657 287.0
TLS1_k127_715435_3 PFAM ABC transporter K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005387 263.0
TLS1_k127_715435_4 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000008528 237.0
TLS1_k127_715435_5 Ribosome biogenesis protein, C-terminal K09140 - - 0.000000000000000000000000000000000000000000000000000002353 195.0
TLS1_k127_715435_6 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000007379 198.0
TLS1_k127_715435_7 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000000000000000000000001873 119.0
TLS1_k127_715435_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000000008205 98.0
TLS1_k127_715435_9 - - - - 0.00000000000000000001615 91.0
TLS1_k127_7218407_0 Succinyl-CoA ligase like flavodoxin domain K18593 - - 7.127e-315 978.0
TLS1_k127_7218407_1 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003628 604.0
TLS1_k127_7218407_2 Zinc finger domain - - - 0.00000000000000000000000000000000000000000000000000000000005374 216.0
TLS1_k127_7218407_3 - - - - 0.000000000000000000000000000000000000000000000000000003518 193.0
TLS1_k127_7218407_4 Belongs to the DEAD box helicase family K05592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.4.13 0.000000000000000006096 84.0
TLS1_k127_7219981_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000003923 160.0
TLS1_k127_7219981_1 methyltransferase K15942 - 2.1.1.288 0.00006065 51.0
TLS1_k127_7223691_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004386 297.0
TLS1_k127_7223691_1 Purple acid Phosphatase, N-terminal domain - - - 0.00000000000000000000000008551 118.0
TLS1_k127_7223691_2 Polysaccharide deacetylase - - - 0.00000000002083 74.0
TLS1_k127_722974_0 DEAD DEAH box helicase K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006931 436.0
TLS1_k127_722974_1 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006032 275.0
TLS1_k127_722974_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008959 246.0
TLS1_k127_722974_3 RibD C-terminal domain K14654 - 1.1.1.302 0.000000000000000000000000000000000000000000000000000000000000000009096 231.0
TLS1_k127_7236971_0 CBS domain K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 561.0
TLS1_k127_7236971_1 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 303.0
TLS1_k127_7236971_2 Type I secretion target GGXGXDXXX repeat (2 copies) - - - 0.000000000001841 77.0
TLS1_k127_7236971_3 Dodecin K09165 - - 0.0000006857 53.0
TLS1_k127_7246529_0 cytochrome c biogenesis protein K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 351.0
TLS1_k127_7246529_1 Transcriptional regulator - - - 0.00000000000000000000000000000000002051 137.0
TLS1_k127_7276619_0 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000002822 238.0
TLS1_k127_7280396_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000001642 147.0
TLS1_k127_7280396_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000003179 132.0
TLS1_k127_7280396_2 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.00000000000000000000000000001379 129.0
TLS1_k127_7280396_3 Alpha beta hydrolase - - - 0.000009263 48.0
TLS1_k127_7282636_0 divalent heavy-metal cations transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000001089 235.0
TLS1_k127_7282636_1 iron dependent repressor - - - 0.0000000000000000000000000000000000000000000000000000000005645 205.0
TLS1_k127_7288918_0 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000005396 258.0
TLS1_k127_7288918_1 PFAM TPR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000001594 217.0
TLS1_k127_7288918_3 - - - - 0.0000598 46.0
TLS1_k127_7373731_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 415.0
TLS1_k127_7373731_1 Belongs to the peptidase M24B family K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 372.0
TLS1_k127_7373731_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 340.0
TLS1_k127_7373731_3 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001149 281.0
TLS1_k127_7373731_4 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000002 228.0
TLS1_k127_7373731_5 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.0000000000000000000000000000000000000000000166 166.0
TLS1_k127_7373731_6 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.00000000000000000000008432 100.0
TLS1_k127_738676_0 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000008381 224.0
TLS1_k127_738676_1 - - - - 0.00000000000000000000000000000000000000000008265 167.0
TLS1_k127_738676_2 - - - - 0.000000000000000000000000003698 121.0
TLS1_k127_738676_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665,K06883 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.000003529 51.0
TLS1_k127_7412507_0 Type III restriction enzyme, res subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000002978 235.0
TLS1_k127_7412507_1 PFAM PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000001556 167.0
TLS1_k127_7433322_0 SnoaL-like polyketide cyclase - - - 0.000000000000000006223 89.0
TLS1_k127_7433322_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K10126 - - 0.000005387 54.0
TLS1_k127_7440048_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 371.0
TLS1_k127_7440048_1 3-isopropylmalate dehydratase, small subunit K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000009538 259.0
TLS1_k127_7465150_0 AAA domain K19036 - 3.6.4.12,3.6.4.13 0.000000001507 69.0
TLS1_k127_7485501_0 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 409.0
TLS1_k127_7485501_1 binding-protein-dependent transport systems inner membrane component K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000006027 235.0
TLS1_k127_7485501_2 TIGRFAM phosphate ABC transporter K02040 - - 0.00000000000000000000000000000000000000000000000002225 182.0
TLS1_k127_7486162_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 383.0
TLS1_k127_7486162_1 SUF system FeS assembly protein K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000001934 228.0
TLS1_k127_7486162_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000002836 118.0
TLS1_k127_7486162_3 - - - - 0.0000000001097 66.0
TLS1_k127_7591088_0 Belongs to the RtcB family K14415 - 6.5.1.3 6.243e-246 766.0
TLS1_k127_7591088_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000005156 267.0
TLS1_k127_7591088_2 Located on the platform of the 30S subunit K02948 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002028 248.0
TLS1_k127_7591088_3 - - - - 0.000000000000000000000000000000005247 132.0
TLS1_k127_7591110_0 Histone acetyltransferase K07739 - 2.3.1.48 2.151e-203 646.0
TLS1_k127_7614217_0 Hydroxymethylglutaryl-coenzyme A synthase N terminal K01641 - 2.3.3.10 5.914e-231 720.0
TLS1_k127_7614217_1 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 532.0
TLS1_k127_7614217_2 Radical SAM K18285 - 2.5.1.120 0.00000000001849 66.0
TLS1_k127_7625833_0 Histidine kinase-like ATPases K07677,K07679,K13924,K20974 - 2.1.1.80,2.7.13.3,3.1.1.61 0.000000000000000007646 88.0
TLS1_k127_7629613_0 Protein of unknown function (DUF1211) - - - 0.00000000000000000000000000000000004197 141.0
TLS1_k127_7629613_1 Dienelactone hydrolase family - - - 0.0000000000000000000000000711 111.0
TLS1_k127_7642753_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 402.0
TLS1_k127_7642753_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 366.0
TLS1_k127_7642753_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 331.0
TLS1_k127_7642753_3 Ribosomal L37ae protein family K02921 - - 0.000000000000000000000000000006713 120.0
TLS1_k127_7646239_0 methanogenesis marker protein 1 K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 576.0
TLS1_k127_7646239_1 Ribosomal protein L15E K02877 - - 0.000000000000000000000000000000000000000000000000000000000000000000001993 238.0
TLS1_k127_7646239_2 PFAM TfuA domain protein, core - - - 0.00000000000000000000000000000000000000000000000000000000000004936 220.0
TLS1_k127_7646239_3 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000003267 167.0
TLS1_k127_7646239_4 - - - - 0.000000000000000000000000008859 114.0
TLS1_k127_7648086_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 541.0
TLS1_k127_7648086_1 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 362.0
TLS1_k127_7648086_2 - - - - 0.0000000000000000000000000000000000000001008 160.0
TLS1_k127_7659665_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 460.0
TLS1_k127_7659665_1 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001083 288.0
TLS1_k127_7659665_2 - - - - 0.00000000000000000000000000000008519 126.0
TLS1_k127_7718479_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 473.0
TLS1_k127_7718479_1 phosphoribosylglycinamide formyltransferase K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000006408 259.0
TLS1_k127_7718479_2 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000002872 199.0
TLS1_k127_7718479_3 - - - - 0.0000000000000000009377 89.0
TLS1_k127_7718479_4 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.0000000000000009667 78.0
TLS1_k127_7735155_0 ATP synthase subunit a, chloroplastic - - - 0.000000000000000000000000000000001397 130.0
TLS1_k127_7735155_1 30S ribosomal protein S2, chloroplastic K02967 GO:0000313,GO:0000314,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0031974,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0070013,GO:0071704,GO:0098798,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000003169 124.0
TLS1_k127_7735155_2 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009544,GO:0009579,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031976,GO:0031984,GO:0032991,GO:0033177,GO:0034220,GO:0034357,GO:0042623,GO:0042625,GO:0042626,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044422,GO:0044424,GO:0044425,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0051179,GO:0051234,GO:0055035,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098807,GO:0099131,GO:0099132,GO:1902600 - 0.0000000009311 59.0
TLS1_k127_7748248_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006314 373.0
TLS1_k127_775650_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 1.428e-195 613.0
TLS1_k127_775650_1 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009936 314.0
TLS1_k127_7763181_0 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003747 482.0
TLS1_k127_7763181_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 417.0
TLS1_k127_7763181_2 Phosphoenolpyruvate phosphomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 394.0
TLS1_k127_7763181_3 Transcriptional regulator PadR-like family - - - 0.0000000000000000000000000000000000000000000000000000000005909 205.0
TLS1_k127_7763181_4 protein conserved in archaea K09723 - - 0.000000000000000000000000000000000001566 145.0
TLS1_k127_7763181_5 Belongs to the ribosomal protein L31e family K02910 - - 0.00000000000000000000000000000009481 126.0
TLS1_k127_7763181_6 - - - - 0.00000000000000000002889 93.0
TLS1_k127_7763181_7 Belongs to the eukaryotic ribosomal protein eL39 family K02924 - - 0.0000000000000000007781 86.0
TLS1_k127_7763181_8 - - - - 0.0000000000001418 72.0
TLS1_k127_7767983_0 Domain of unknown function (DUF202) K00389 - - 0.00000000000000000000002233 104.0
TLS1_k127_7767983_1 CBS domain - - - 0.00000000108 63.0
TLS1_k127_7770046_0 CBS domain - - - 0.00000000000000000000000000000000003931 145.0
TLS1_k127_7770046_1 Polysaccharide deacetylase - - - 0.0000138 49.0
TLS1_k127_7770550_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 2.048e-211 665.0
TLS1_k127_7770550_1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 445.0
TLS1_k127_7771230_0 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000136 273.0
TLS1_k127_7771230_1 ribosomal protein K02956 - - 0.00000000000000000000000000000000000000000000000000000000000001418 218.0
TLS1_k127_7780564_0 glycosyl transferase family K01001 - 2.7.8.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002033 424.0
TLS1_k127_7780564_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004585 266.0
TLS1_k127_7785968_0 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006122 450.0
TLS1_k127_7830699_0 Archaeal Nre, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 410.0
TLS1_k127_7847063_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 2.923e-194 613.0
TLS1_k127_7847063_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000009899 164.0
TLS1_k127_7847063_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000009651 89.0
TLS1_k127_7874147_0 Zinc-binding dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 310.0
TLS1_k127_7874147_1 PFAM Alcohol dehydrogenase K13979 - - 0.0000000000000000000000000000000000000000000000000000000003082 204.0
TLS1_k127_7886448_0 Cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 439.0
TLS1_k127_7886448_1 tRNA methyl transferase K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 299.0
TLS1_k127_7886448_2 biotin carboxyl carrier K00627,K01571,K15037,K18605 - 2.3.1.12,4.1.1.3 0.00000000000000000000000000000000000000007689 154.0
TLS1_k127_7887202_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 503.0
TLS1_k127_7887202_1 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 315.0
TLS1_k127_7887202_2 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 287.0
TLS1_k127_7887202_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000042 141.0
TLS1_k127_7887202_4 Ribosomal protein S30 K02983 - - 0.00000000000000000006047 90.0
TLS1_k127_7887202_5 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000008763 90.0
TLS1_k127_7890338_0 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002423 266.0
TLS1_k127_790154_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003917 381.0
TLS1_k127_790154_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000002244 85.0
TLS1_k127_7903747_0 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002345 276.0
TLS1_k127_7907950_0 Subtilase family K14645 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 308.0
TLS1_k127_7936281_0 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 303.0
TLS1_k127_7936281_1 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000000000000000000000000000000000002404 171.0
TLS1_k127_7936281_2 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000013 91.0
TLS1_k127_7942632_0 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 482.0
TLS1_k127_7942632_1 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 329.0
TLS1_k127_7944647_0 factor TFIIB K03124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 416.0
TLS1_k127_7944647_1 - - - - 0.0000000000000000000000000000008343 124.0
TLS1_k127_7944647_2 RNA-binding protein involved in rRNA processing K07569 - - 0.00000000000002871 76.0
TLS1_k127_7971396_0 this gene contains a nucleotide ambiguity which may be the result of a sequencing error - - - 0.000000000000000000000000000000000000000000000000000000000004757 211.0
TLS1_k127_7971396_1 Cupin superfamily (DUF985) K09705 - - 0.0000000000000000000000000000000000000000000000000000007285 196.0
TLS1_k127_7971396_2 Transposase - - - 0.000000000000000003803 90.0
TLS1_k127_7971396_3 Nucleotidyl transferase - - - 0.0000000000000004199 79.0
TLS1_k127_7973961_0 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 347.0
TLS1_k127_7977035_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001893 255.0
TLS1_k127_7977035_1 - - - - 0.0000000000000000866 87.0
TLS1_k127_7979322_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 410.0
TLS1_k127_7987139_0 PFAM Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003703 245.0
TLS1_k127_7987139_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000001152 214.0
TLS1_k127_7987139_2 Belongs to the UPF0201 family K09736 - - 0.0000000000000000000000000000006502 126.0
TLS1_k127_7998146_0 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000772 359.0
TLS1_k127_7998146_1 Universal stress protein - - - 0.000000000000001376 81.0
TLS1_k127_7998146_2 Biotin carboxyl carrier protein K01960 - 6.4.1.1 0.00000000000001396 79.0
TLS1_k127_8001735_0 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000005634 229.0
TLS1_k127_8001735_1 - - - - 0.00000000000000000000000001165 114.0
TLS1_k127_8003396_0 Type III restriction enzyme, res subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 488.0
TLS1_k127_8003396_1 restriction endonuclease K07448 - - 0.0000001793 57.0
TLS1_k127_8024615_0 TIGRFAM ParB RepB Spo0J family partition protein K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003363 247.0
TLS1_k127_8078902_1 Transcriptional regulator K02483 - - 0.000000000001518 72.0
TLS1_k127_8078902_2 Psort location Cytoplasmic, score 9.97 - - - 0.000009172 57.0
TLS1_k127_8081688_0 Pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 490.0
TLS1_k127_809703_0 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000001015 228.0
TLS1_k127_809703_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.0000000000000000008093 90.0
TLS1_k127_809703_2 poly(R)-hydroxyalkanoic acid synthase subunit PhaC K03821 - - 0.00007302 46.0
TLS1_k127_811647_0 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 423.0
TLS1_k127_811647_1 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 298.0
TLS1_k127_811647_2 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000001421 133.0
TLS1_k127_811647_3 snRNP Sm proteins K04796 - - 0.0000000000000000634 82.0
TLS1_k127_820823_0 CHRD domain - - - 0.00000000000000000000000000000006544 130.0
TLS1_k127_820823_1 - - - - 0.0000000000000000004593 89.0
TLS1_k127_828473_0 - - - - 0.0000000002 67.0
TLS1_k127_833726_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 564.0
TLS1_k127_837613_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009746 486.0
TLS1_k127_837613_1 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000005266 216.0
TLS1_k127_847592_0 Acyl CoA acetate 3-ketoacid CoA transferase K01026 - 2.8.3.1 0.0000000000000000000000000000000000000000000000000000002713 197.0
TLS1_k127_847592_1 Rhodanese Homology Domain - - - 0.000000000000000000000000000000005971 142.0
TLS1_k127_866845_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 - - 3.767e-241 749.0
TLS1_k127_866845_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 374.0
TLS1_k127_866845_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000004454 193.0
TLS1_k127_866845_3 ribosomal protein K02912 - - 0.00000000000000000000000000000000000000000000000003606 181.0
TLS1_k127_866845_4 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.00000000000000000000000007625 108.0
TLS1_k127_866845_5 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000008377 106.0
TLS1_k127_866845_6 Protein tyrosine kinase - - - 0.000004891 55.0
TLS1_k127_877796_0 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 353.0
TLS1_k127_877796_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 286.0
TLS1_k127_877796_2 - - - - 0.0000000000007413 77.0
TLS1_k127_877796_3 - - - - 0.000001342 55.0
TLS1_k127_880016_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00000000000000000000000000001659 124.0
TLS1_k127_880016_1 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000006363 78.0
TLS1_k127_880016_2 - - - - 0.00000000000315 70.0
TLS1_k127_880016_3 - - - - 0.0000003761 55.0
TLS1_k127_88676_0 TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 - 2.6.1.16 3.565e-227 717.0
TLS1_k127_88676_1 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000008477 128.0
TLS1_k127_88676_2 PFAM S-layer - - - 0.00000223 53.0
TLS1_k127_9070_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008135 431.0
TLS1_k127_9070_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003737 262.0
TLS1_k127_945038_0 Lactonase, 7-bladed beta-propeller K07404 - 3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 342.0
TLS1_k127_945038_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000003595 193.0