Overview

ID MAG03978
Name TLS1_bin.5
Sample SMP0103
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Thermoanaerobaculia
Order Gp7-AA8
Family Gp7-AA8
Genus QHVT01
Species
Assembly information
Completeness (%) 85.13
Contamination (%) 4.02
GC content (%) 63.0
N50 (bp) 5,723
Genome size (bp) 4,280,628

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3615

Gene name Description KEGG GOs EC E-value Score Sequence
TLS1_k127_100291_0 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002643 282.0
TLS1_k127_100291_1 phosphoserine phosphatase activity K07052,K07315 - 3.1.3.3 0.000000000000000000000000000002068 126.0
TLS1_k127_100291_2 antisigma factor binding K04749,K06378 - - 0.000000000000000000000000008275 115.0
TLS1_k127_100291_3 Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K04757 - 2.7.11.1 0.00000000000000000000000783 111.0
TLS1_k127_100291_4 zinc-ribbon domain - - - 0.0008372 50.0
TLS1_k127_101507_0 lipoprotein localization to outer membrane K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 319.0
TLS1_k127_101507_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000005144 220.0
TLS1_k127_101507_2 nucleotide metabolic process - - - 0.0000000000000001041 86.0
TLS1_k127_102079_0 Autotransporter beta-domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 357.0
TLS1_k127_102079_1 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 307.0
TLS1_k127_102079_2 Pfam:Arch_ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001837 282.0
TLS1_k127_102079_3 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000001247 156.0
TLS1_k127_102079_4 zinc-ribbon domain - - - 0.00000000000000000000000000007429 127.0
TLS1_k127_102079_5 chemotaxis K02659,K03408,K03415 - - 0.0000000000002702 80.0
TLS1_k127_1024215_0 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 320.0
TLS1_k127_1024215_1 Histidine kinase-like ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006178 280.0
TLS1_k127_1024215_2 Domain of unknown function (DUF4331) - - - 0.0000000000000000000000000000000000000000000000000000000000000004448 243.0
TLS1_k127_1024215_3 PFAM Na dependent nucleoside transporter K03317 - - 0.00000000007709 66.0
TLS1_k127_1031728_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000002246 252.0
TLS1_k127_1031728_1 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000003346 225.0
TLS1_k127_1031728_2 - - - - 0.0007563 44.0
TLS1_k127_1053716_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000977 294.0
TLS1_k127_1053716_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000339 301.0
TLS1_k127_1053716_2 pteridine-dependent deoxygenase K18240 - 4.1.3.40,4.1.3.45 0.000000000000000000000000000000000000000000000000001232 194.0
TLS1_k127_1053716_3 TIR domain - - - 0.000000000000000000000000000000000000000001208 171.0
TLS1_k127_1053716_4 Predicted integral membrane protein (DUF2269) - - - 0.000000000000000000000005981 108.0
TLS1_k127_1053716_6 - - - - 0.00000000000000002416 85.0
TLS1_k127_1053716_7 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00002135 48.0
TLS1_k127_1055816_0 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 331.0
TLS1_k127_1055816_1 peptidase M4 thermolysin K01400 - 3.4.24.28 0.0000000000002848 78.0
TLS1_k127_1058347_0 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 2.749e-228 727.0
TLS1_k127_1082041_0 cellulose binding - - - 2.189e-264 833.0
TLS1_k127_1082041_1 CAAX prenyl protease N-terminal, five membrane helices - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001725 282.0
TLS1_k127_1098188_0 sigma factor activity K02405 - - 0.00000000000000000000001333 107.0
TLS1_k127_1098188_1 - - - - 0.000000001887 70.0
TLS1_k127_1098188_2 SnoaL-like domain - - - 0.0000000786 59.0
TLS1_k127_1105302_0 Zinc metalloprotease (Elastase) K01400,K08604 - 3.4.24.25,3.4.24.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 403.0
TLS1_k127_1105302_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002081 293.0
TLS1_k127_1105302_10 Ankyrin repeats (many copies) - - - 0.00003892 55.0
TLS1_k127_1105302_2 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000002687 211.0
TLS1_k127_1105302_3 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000008194 168.0
TLS1_k127_1105302_4 EamA-like transporter family - - - 0.00000000000000000000000000000000002858 147.0
TLS1_k127_1105302_5 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000003883 113.0
TLS1_k127_1105302_6 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000001185 116.0
TLS1_k127_1105302_7 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.00000000000000000000000004805 124.0
TLS1_k127_1105302_8 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000004946 73.0
TLS1_k127_1105302_9 Belongs to the ABC transporter superfamily K02031,K02032,K13892,K13896 - - 0.000004836 58.0
TLS1_k127_1114883_0 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004751 321.0
TLS1_k127_1114883_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000009263 196.0
TLS1_k127_1119861_0 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000002357 197.0
TLS1_k127_1119861_1 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000002674 131.0
TLS1_k127_1119861_2 dipeptide transport K02035 - - 0.0000000000000000000000001184 112.0
TLS1_k127_1119861_3 TIGRFAM VWFA-related Acidobacterial domain - - - 0.000000008728 68.0
TLS1_k127_1134867_0 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000001245 137.0
TLS1_k127_1134867_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000004221 86.0
TLS1_k127_1134867_2 Two component transcriptional regulator, winged helix family K07657,K07658 - - 0.0000000000000003966 86.0
TLS1_k127_114398_0 Polysaccharide biosynthesis protein CapD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004047 440.0
TLS1_k127_114398_1 Serine/threonine phosphatases, family 2C, catalytic domain K01090 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000001444 211.0
TLS1_k127_114398_2 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000001471 187.0
TLS1_k127_114398_3 - - - - 0.000000000000000000000000000000000244 147.0
TLS1_k127_114398_4 Domain of unknown function (DUF4115) K15539 - - 0.000000000000000000002403 104.0
TLS1_k127_114398_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - 0.0000000000001899 79.0
TLS1_k127_114398_6 - - - - 0.00000000006873 74.0
TLS1_k127_114398_7 PFAM sugar transferase - - - 0.00004872 46.0
TLS1_k127_1146130_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 606.0
TLS1_k127_1146130_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001032 267.0
TLS1_k127_1146130_10 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000003745 161.0
TLS1_k127_1146130_11 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000004542 159.0
TLS1_k127_1146130_12 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000005865 154.0
TLS1_k127_1146130_13 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000000000006365 133.0
TLS1_k127_1146130_14 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000003526 117.0
TLS1_k127_1146130_15 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000004912 100.0
TLS1_k127_1146130_16 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000006605 99.0
TLS1_k127_1146130_17 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000003433 69.0
TLS1_k127_1146130_18 50S ribosomal protein L30 K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000002792 68.0
TLS1_k127_1146130_19 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000007791 61.0
TLS1_k127_1146130_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007653 252.0
TLS1_k127_1146130_3 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000154 253.0
TLS1_k127_1146130_4 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000002201 230.0
TLS1_k127_1146130_5 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000003163 225.0
TLS1_k127_1146130_6 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000001592 211.0
TLS1_k127_1146130_7 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000002933 207.0
TLS1_k127_1146130_8 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000007846 183.0
TLS1_k127_1146130_9 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000001972 172.0
TLS1_k127_1172422_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 316.0
TLS1_k127_1172422_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000001136 186.0
TLS1_k127_1172422_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000000000002136 160.0
TLS1_k127_1172422_3 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000001526 95.0
TLS1_k127_1172422_4 SdrD B-like domain - - - 0.0001303 55.0
TLS1_k127_1172422_5 Alpha beta hydrolase - - - 0.0006768 50.0
TLS1_k127_1172640_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 546.0
TLS1_k127_1172640_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000003328 167.0
TLS1_k127_1193511_0 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000001073 267.0
TLS1_k127_119807_0 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000004913 206.0
TLS1_k127_119807_1 Glycosyl transferase family group 2 - - - 0.0000000000000000002499 99.0
TLS1_k127_1199196_0 ASPIC UnbV domain protein - - - 1.743e-296 941.0
TLS1_k127_1199196_1 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006535 609.0
TLS1_k127_1199196_2 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 571.0
TLS1_k127_1199196_3 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008174 398.0
TLS1_k127_1213876_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001482 279.0
TLS1_k127_1213876_1 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.000000000000000000000000000000000000000000000000002419 191.0
TLS1_k127_1213876_2 PFAM Excinuclease ABC, C subunit domain protein K07461 - - 0.00000000000000000003814 93.0
TLS1_k127_1213876_3 Psort location CytoplasmicMembrane, score - - - 0.000005398 56.0
TLS1_k127_126616_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 3.679e-223 706.0
TLS1_k127_126616_1 Transcription factor zinc-finger K09981 - - 0.0000000000000000000000000001572 118.0
TLS1_k127_126616_2 DREV methyltransferase - - - 0.000000000002857 72.0
TLS1_k127_1271748_0 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000003801 265.0
TLS1_k127_1271748_1 chaperone - - - 0.000000000000000000000678 98.0
TLS1_k127_1271748_2 Appr-1'-p processing enzyme - - - 0.0000000000000001772 84.0
TLS1_k127_1271748_3 Belongs to the EPSP synthase family K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000005289 72.0
TLS1_k127_1271748_4 UDP-2,3-diacylglucosamine hydrolase K03269 - 3.6.1.54 0.0000000001053 74.0
TLS1_k127_1272703_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000003652 185.0
TLS1_k127_1272703_1 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000007471 145.0
TLS1_k127_1272775_0 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 447.0
TLS1_k127_1272775_1 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000007727 202.0
TLS1_k127_1272775_2 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000002378 156.0
TLS1_k127_1272775_3 E1 N-terminal domain - - - 0.000000000000000000000000000000002555 147.0
TLS1_k127_1272775_4 Predicted metal binding domain - - - 0.0000000000000000001108 95.0
TLS1_k127_1272775_5 Prokaryotic homologs of the JAB domain - - - 0.000000000000000009938 90.0
TLS1_k127_1272775_6 - - - - 0.000000000002865 70.0
TLS1_k127_1272775_7 - - - - 0.000000006102 62.0
TLS1_k127_1272775_8 Putative zinc-finger - - - 0.00000752 52.0
TLS1_k127_1280858_0 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 434.0
TLS1_k127_1280858_1 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000004328 191.0
TLS1_k127_1280858_2 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016791,GO:0019143,GO:0033692,GO:0034637,GO:0034645,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 0.0000000000000000000000000000000000000000874 156.0
TLS1_k127_1280858_3 Competence protein - - - 0.00000000000000000001489 101.0
TLS1_k127_1284237_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 588.0
TLS1_k127_1284237_1 Peptidase family C25 - - - 0.0000000000000000000001567 115.0
TLS1_k127_1284237_2 alginic acid biosynthetic process K12287 - - 0.00000000000000001717 98.0
TLS1_k127_1289707_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000002463 198.0
TLS1_k127_1289707_1 Uracil DNA glycosylase superfamily K03648 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000002043 194.0
TLS1_k127_1314746_0 arylsulfatase A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006117 296.0
TLS1_k127_1318892_0 nitrite reductase [NAD(P)H] activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 300.0
TLS1_k127_1318892_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000138 260.0
TLS1_k127_1318892_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000003596 94.0
TLS1_k127_1318892_3 Dienelactone hydrolase family - - - 0.0000000000000000002436 90.0
TLS1_k127_1318892_4 Psort location CytoplasmicMembrane, score - - - 0.00000000000005248 85.0
TLS1_k127_1324166_0 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 291.0
TLS1_k127_1324166_1 TonB-dependent Receptor Plug Domain K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008574 289.0
TLS1_k127_1324166_2 ATPase activity - - - 0.00000000000000000000000000000000000000000000000000000000008787 212.0
TLS1_k127_1324166_3 - - - - 0.000000000003972 76.0
TLS1_k127_133058_0 PFAM Type II secretion system protein E K02652 - - 3.056e-223 705.0
TLS1_k127_133058_1 PFAM Type II secretion system F domain K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 308.0
TLS1_k127_1343969_0 Glucose dehydrogenase C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 295.0
TLS1_k127_1343969_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000006021 184.0
TLS1_k127_1345335_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005224 273.0
TLS1_k127_1345335_1 Domain of unknown function (DUF4142) K08995 - - 0.00000000000000000000000000007997 125.0
TLS1_k127_1345335_2 HAMP domain - - - 0.00000000000007421 76.0
TLS1_k127_1353586_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006725 328.0
TLS1_k127_1353586_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.000000000000000000000000203 115.0
TLS1_k127_135441_0 PFAM Mammalian cell entry related K06192 - - 0.000000000000000000000000001792 123.0
TLS1_k127_135441_1 ABC-type transport auxiliary lipoprotein component K09857 - - 0.000000000000001175 90.0
TLS1_k127_1367075_0 ACT domain K12524 - 1.1.1.3,2.7.2.4 1.365e-199 651.0
TLS1_k127_1367075_1 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) K02551 - 2.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 376.0
TLS1_k127_1367075_2 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 298.0
TLS1_k127_1367075_3 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003929 275.0
TLS1_k127_1367075_4 Isochorismate synthase K01851,K02361,K02552 - 5.4.4.2 0.0000000000000000000000000000000000000000000003611 183.0
TLS1_k127_1367075_5 homoserine K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009617,GO:0009620,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0050896,GO:0051704,GO:0051707,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000001852 149.0
TLS1_k127_1367075_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000006554 129.0
TLS1_k127_1367075_7 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K08680 - 4.2.99.20 0.00000000000000000006941 95.0
TLS1_k127_1367075_8 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000001537 93.0
TLS1_k127_1367075_9 Ribbon-helix-helix protein, copG family K21495 - - 0.0000001122 54.0
TLS1_k127_1370795_0 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 422.0
TLS1_k127_1370795_1 Protein of unknown function (DUF1573) - - - 0.00000000000000000005289 101.0
TLS1_k127_1374372_0 Nacht domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 543.0
TLS1_k127_1374372_1 transcriptional regulator - - - 0.00000000000000000000000000000000005356 145.0
TLS1_k127_1374372_2 Aminotransferase class I and II - - - 0.000000000000382 72.0
TLS1_k127_1375186_0 Protein of unknown function (DUF4236) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000995 387.0
TLS1_k127_1383641_0 Elongation factor G, domain IV K02355 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 534.0
TLS1_k127_1383864_0 carbohydrate metabolic process - - - 4.762e-260 831.0
TLS1_k127_1383864_1 Beta-eliminating lyase K01668 - 4.1.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005175 512.0
TLS1_k127_1383864_2 cyclic nucleotide-binding K01420,K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006201 278.0
TLS1_k127_1383864_3 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001327 263.0
TLS1_k127_1383864_4 polymorphic outer membrane protein - - - 0.0000000000000000000000000000000000000000000000000000003204 221.0
TLS1_k127_1383864_5 Belongs to the peptidase S8 family K14645 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000009847 200.0
TLS1_k127_1383864_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000006105 137.0
TLS1_k127_1390220_0 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 2.151e-248 779.0
TLS1_k127_1390220_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 535.0
TLS1_k127_1390220_2 Chaperone of endosialidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 375.0
TLS1_k127_1390220_3 arylsulfatase A - - - 0.000000000000000000000000000000000000189 160.0
TLS1_k127_1390220_4 - - - - 0.00000004451 64.0
TLS1_k127_1390220_5 cell wall surface anchor family protein - - - 0.00002321 56.0
TLS1_k127_1407831_0 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000001411 245.0
TLS1_k127_1407831_1 MASE1 K07315,K21084 - 2.7.7.65,3.1.3.3 0.00000000002011 68.0
TLS1_k127_1414088_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 453.0
TLS1_k127_1414088_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006694 350.0
TLS1_k127_1414088_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 302.0
TLS1_k127_1414088_3 GTP binding K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001094 284.0
TLS1_k127_1425293_0 Pyridine nucleotide-disulphide oxidoreductase - - - 1.447e-196 626.0
TLS1_k127_1432688_0 Transport of potassium into the cell K03549 - - 1.727e-220 700.0
TLS1_k127_1432688_1 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 431.0
TLS1_k127_1434124_0 von Willebrand factor, type A - - - 0.0000000000000000000000000000004965 142.0
TLS1_k127_1434124_1 von Willebrand factor (vWF) type A domain K07114 - - 0.00000000000000000000000000005299 134.0
TLS1_k127_1434124_2 Uncharacterized protein family UPF0016 - - - 0.0000000000000000005289 100.0
TLS1_k127_1434124_3 chaperone-mediated protein folding - - - 0.00000000000001502 88.0
TLS1_k127_144043_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.367e-231 743.0
TLS1_k127_144043_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006651 407.0
TLS1_k127_144043_2 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000003383 137.0
TLS1_k127_1443539_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.842e-268 854.0
TLS1_k127_1443539_1 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 5.574e-226 708.0
TLS1_k127_1443539_2 PFAM Thiamine pyrophosphate K00175,K00187 - 1.2.7.11,1.2.7.3,1.2.7.7 1.222e-202 640.0
TLS1_k127_1443539_3 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 520.0
TLS1_k127_1443539_4 Protein of unknown function (DUF3800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002982 278.0
TLS1_k127_1443539_5 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000001384 269.0
TLS1_k127_1443539_6 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000005629 182.0
TLS1_k127_1443539_7 Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base - - - 0.000000000000000000000002463 108.0
TLS1_k127_145172_0 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000001485 195.0
TLS1_k127_145172_1 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000589 156.0
TLS1_k127_145172_2 Membrane proteins related to metalloendopeptidases K21471 - - 0.000000000000000000000000000004253 132.0
TLS1_k127_1470014_0 PFAM Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 535.0
TLS1_k127_1470014_1 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002057 255.0
TLS1_k127_1470014_2 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000001878 248.0
TLS1_k127_1470014_3 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000001343 220.0
TLS1_k127_1470014_4 - - - - 0.000000000000006625 79.0
TLS1_k127_1477660_0 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.0000000000000000000000000000000000000000000000000000000000008214 220.0
TLS1_k127_1477660_1 Domain of Unknown function (DUF542) K07322 - - 0.000000000000000000000000000000000000000000000000000006561 199.0
TLS1_k127_1477660_2 helix_turn_helix, cAMP Regulatory protein K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.00000000000000000000000000000001224 135.0
TLS1_k127_1477660_3 YwiC-like protein - - - 0.0000000000000000000000008289 111.0
TLS1_k127_1477835_0 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 439.0
TLS1_k127_1477835_1 SnoaL-like domain K06893 - - 0.0000000000000000000000000000000000000004659 152.0
TLS1_k127_1477835_2 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000008088 135.0
TLS1_k127_1477835_3 carboxylic ester hydrolase activity - - - 0.0000000000000003919 87.0
TLS1_k127_1514981_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 624.0
TLS1_k127_1514981_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004558 365.0
TLS1_k127_1514981_2 HAD superfamily, subfamily IIIB (Acid phosphatase) - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000001883 208.0
TLS1_k127_1516038_0 DEAD DEAH box helicase K03654 - 3.6.4.12 2.581e-203 655.0
TLS1_k127_1516038_1 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000035 258.0
TLS1_k127_1516038_2 Fic/DOC family K07341 - - 0.0000000000000000000000000000000000009586 142.0
TLS1_k127_1516038_3 Coagulation factor 5 8 type domain protein - - - 0.0000000003481 71.0
TLS1_k127_1516038_4 PFAM SpoVT AbrB K07172,K18842 - - 0.000000001549 63.0
TLS1_k127_152706_0 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 492.0
TLS1_k127_1528073_0 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 309.0
TLS1_k127_1528073_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001624 258.0
TLS1_k127_1528073_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000006533 205.0
TLS1_k127_1528073_3 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000000001782 202.0
TLS1_k127_1528073_4 M1 (1,4-beta-N-acetylmuramidase) K07273 - - 0.000000000000000000000000000000000000000008802 160.0
TLS1_k127_1528073_5 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000000006265 108.0
TLS1_k127_1528073_6 - - - - 0.0000000000000000000000004519 106.0
TLS1_k127_1533239_0 Belongs to the pyruvate kinase family K00873 GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 422.0
TLS1_k127_1533239_1 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001502 236.0
TLS1_k127_1535502_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006189 312.0
TLS1_k127_1535502_1 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000007194 216.0
TLS1_k127_1535502_11 Putative transmembrane protein (PGPGW) - - - 0.000718 48.0
TLS1_k127_1535502_2 phytanoyl-CoA dioxygenase - - - 0.0000000000000000000000000000000000000000000000003163 183.0
TLS1_k127_1535502_3 TRANSCRIPTIONal - - - 0.000000000000000000000000000000000000000005146 167.0
TLS1_k127_1535502_4 - - - - 0.000000000000000000000000000000000009014 149.0
TLS1_k127_1535502_5 Ndr family - - - 0.00000000000000000000000006632 121.0
TLS1_k127_1535502_6 ATP-binding region ATPase domain protein, response regulator receiver, histidine kinase A domain protein - - - 0.0000000000001464 77.0
TLS1_k127_1535502_7 - - - - 0.0000000000001647 76.0
TLS1_k127_1535502_8 Transcriptional regulatory protein, C terminal K02483,K07666 - - 0.000000000002293 77.0
TLS1_k127_1535502_9 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000004963 61.0
TLS1_k127_1539617_0 Alpha-2-Macroglobulin K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 581.0
TLS1_k127_1544629_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 1.636e-253 790.0
TLS1_k127_1544629_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 433.0
TLS1_k127_1544629_10 Adenylate cyclase - - - 0.000000000000001303 85.0
TLS1_k127_1544629_11 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000002156 77.0
TLS1_k127_1544629_12 FHA domain - - - 0.0000000008562 68.0
TLS1_k127_1544629_2 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000002976 195.0
TLS1_k127_1544629_3 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000005735 170.0
TLS1_k127_1544629_4 glycosyl transferase, family 2 K20444 - - 0.00000000000000000000000000000000001542 155.0
TLS1_k127_1544629_5 response to radiation - GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0033554,GO:0042221,GO:0046677,GO:0050896,GO:0051716 - 0.000000000000000000000003048 111.0
TLS1_k127_1544629_6 Haloacid dehalogenase-like hydrolase K07025,K20866 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050308 3.1.3.10 0.00000000000000000000003074 107.0
TLS1_k127_1544629_7 - - - - 0.0000000000000000009136 91.0
TLS1_k127_1544629_8 - - - - 0.000000000000000003075 97.0
TLS1_k127_1544629_9 transferase activity, transferring glycosyl groups - - - 0.0000000000000001295 92.0
TLS1_k127_1563393_0 transferase activity, transferring glycosyl groups K00754 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000000102 237.0
TLS1_k127_1563393_1 N-acetylglucosaminylinositol deacetylase activity K01463 - - 0.000000000000000000000000000000000000000000000000000000000000000006568 237.0
TLS1_k127_1563393_2 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000001873 165.0
TLS1_k127_1563393_3 Belongs to the BshC family K22136 - - 0.0000000000000000000000000000000000000003044 168.0
TLS1_k127_1570262_0 DNA methyltransferase K07318 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000003 215.0
TLS1_k127_1570262_1 metalloendopeptidase activity - - - 0.000000000000000000000000000206 124.0
TLS1_k127_1570262_2 Diguanylate cyclase - - - 0.000000000000000000003337 110.0
TLS1_k127_1570262_3 HAD-superfamily hydrolase, subfamily IIB - - - 0.000000000000000003704 96.0
TLS1_k127_1570262_4 DNA-templated transcription, initiation K03088,K03091 - - 0.0000000000000001795 86.0
TLS1_k127_1570262_5 metalloendopeptidase activity - - - 0.000000000000001469 91.0
TLS1_k127_1570262_6 outer membrane protein W K07275 - - 0.000000001632 68.0
TLS1_k127_157226_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 374.0
TLS1_k127_157226_1 KR domain K08081 - 1.1.1.206 0.000000000000000000000000000000000000000000000000000000000000000000000000000006949 267.0
TLS1_k127_157226_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000009253 261.0
TLS1_k127_157226_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000002994 195.0
TLS1_k127_157226_4 YbbR-like protein - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.000007468 57.0
TLS1_k127_1572382_0 cyclic nucleotide binding K10914 - - 0.00000000000000000000000000000000000000000001581 171.0
TLS1_k127_1572382_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000001059 143.0
TLS1_k127_1572382_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000000000000000000001878 106.0
TLS1_k127_1572382_3 - - - - 0.00007723 49.0
TLS1_k127_1575774_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 424.0
TLS1_k127_1575774_1 competence protein COMEC - - - 0.0000000005149 61.0
TLS1_k127_1583132_0 Psort location CytoplasmicMembrane, score 7.88 K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 316.0
TLS1_k127_1583132_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 303.0
TLS1_k127_1583132_2 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000269 231.0
TLS1_k127_1583132_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000001836 135.0
TLS1_k127_158727_0 3-demethylubiquinone-9 3-O-methyltransferase activity K07011,K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 422.0
TLS1_k127_158727_1 SIS domain K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 287.0
TLS1_k127_158727_2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005121 255.0
TLS1_k127_158727_3 Ornithine cyclodeaminase/mu-crystallin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000287 263.0
TLS1_k127_158727_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000001818 241.0
TLS1_k127_158727_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000003503 222.0
TLS1_k127_158727_6 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000009644 190.0
TLS1_k127_158727_7 Polynucleotide kinase 3 phosphatase - - - 0.00000000000000000000000000000000003637 146.0
TLS1_k127_1598055_0 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 401.0
TLS1_k127_1598055_1 Peptidase S46 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 379.0
TLS1_k127_1608579_0 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000000004285 123.0
TLS1_k127_1608579_1 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000000000007498 115.0
TLS1_k127_1608579_2 Bacterial membrane protein YfhO - - - 0.000000000000000311 91.0
TLS1_k127_1641793_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 3.014e-233 767.0
TLS1_k127_1641793_1 ornithine cyclodeaminase activity K01750,K18258,K19244 - 1.4.1.1,1.5.1.25,4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007046 301.0
TLS1_k127_1641793_2 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002332 295.0
TLS1_k127_1641793_3 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000008483 166.0
TLS1_k127_1641793_4 domain, Protein K03634 - - 0.00000000000000000000000000000000001781 157.0
TLS1_k127_1641793_5 Protein of unknown function (DUF3494) - - - 0.0000000000000000000000002212 119.0
TLS1_k127_1641793_6 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 GO:0000166,GO:0000286,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006522,GO:0006807,GO:0008150,GO:0008152,GO:0009078,GO:0009987,GO:0016491,GO:0016638,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046983,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901605 1.4.1.1 0.0007 43.0
TLS1_k127_1641986_0 ThiF family K21029,K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 452.0
TLS1_k127_1641986_1 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 355.0
TLS1_k127_1641986_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000005952 197.0
TLS1_k127_1641986_3 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000003559 157.0
TLS1_k127_1641986_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000001756 166.0
TLS1_k127_1641986_5 - - - - 0.00000000000000000000000000000000000002571 152.0
TLS1_k127_1641986_6 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000007303 124.0
TLS1_k127_1641986_7 Yqey-like protein K09117 - - 0.00000000000000000000000000004981 121.0
TLS1_k127_1641986_8 Thioesterase-like superfamily K07107 - - 0.0000000000000000009177 96.0
TLS1_k127_1641986_9 Biotin carboxylase, N-terminal domain K01968,K13777 - 6.4.1.4,6.4.1.5 0.00000000000000001768 88.0
TLS1_k127_1651563_0 Bacterial protein of unknown function (DUF885) - - - 1.475e-232 733.0
TLS1_k127_1651563_1 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000003585 186.0
TLS1_k127_1651563_2 Histidine kinase - - - 0.00000000000000000000000000005646 126.0
TLS1_k127_1659084_0 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 445.0
TLS1_k127_1659084_1 NYN domain - - - 0.0000000000000000000000000000000000000000000001725 173.0
TLS1_k127_1659084_2 - - - - 0.0000000000000000000000000000000000000001008 160.0
TLS1_k127_1659084_3 Beta-lactamase - - - 0.00000000000000000000000000000000002629 145.0
TLS1_k127_1659084_4 Beta-lactamase - - - 0.0000000000000000002261 93.0
TLS1_k127_1686529_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 362.0
TLS1_k127_1686529_1 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 328.0
TLS1_k127_1686529_2 Nucleotidyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005113 226.0
TLS1_k127_1686529_3 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.000000000000000000000000000000000000000000000001604 197.0
TLS1_k127_1686529_4 - - - - 0.000000000000000000000000000000000000000001512 160.0
TLS1_k127_1686529_5 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000115 113.0
TLS1_k127_1686529_6 response regulator receiver - - - 0.0000000000001731 81.0
TLS1_k127_1686529_7 PIN domain - - - 0.00000000002616 72.0
TLS1_k127_1686529_8 Bacterial antitoxin of type II TA system, VapB - - - 0.0002197 47.0
TLS1_k127_1723783_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 452.0
TLS1_k127_1723783_1 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 362.0
TLS1_k127_1723783_2 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 339.0
TLS1_k127_1723783_3 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000001635 229.0
TLS1_k127_1723783_4 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000003693 188.0
TLS1_k127_1723783_5 riboflavin synthase, alpha K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.000000000000000000000000000000000000000000000000181 183.0
TLS1_k127_1723783_6 Response regulator receiver domain - - - 0.0000000000000000002157 100.0
TLS1_k127_1723783_7 response regulator - - - 0.00000000000007393 83.0
TLS1_k127_1723783_8 ABC-type multidrug transport system ATPase component - - - 0.00000005365 56.0
TLS1_k127_172718_0 DEAD DEAH box helicase K03724 - - 5.543e-276 854.0
TLS1_k127_1735288_0 Type ii and iii secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002922 295.0
TLS1_k127_1735288_1 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000001838 104.0
TLS1_k127_1735288_2 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000002207 99.0
TLS1_k127_1735288_3 Pilus assembly protein K02662 - - 0.000000000002537 78.0
TLS1_k127_1735288_4 PFAM Fimbrial assembly family protein K02663 - - 0.00000005019 63.0
TLS1_k127_1735288_5 Cartilage oligomeric matrix protein K04659 GO:0001501,GO:0001968,GO:0002020,GO:0003416,GO:0003417,GO:0003674,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005912,GO:0005924,GO:0005927,GO:0007155,GO:0007275,GO:0007517,GO:0008150,GO:0008201,GO:0008289,GO:0009653,GO:0009887,GO:0009888,GO:0009987,GO:0010941,GO:0016043,GO:0016203,GO:0019842,GO:0019899,GO:0022610,GO:0030054,GO:0030055,GO:0030198,GO:0031012,GO:0032501,GO:0032502,GO:0032991,GO:0033627,GO:0035265,GO:0036094,GO:0040007,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043394,GO:0043395,GO:0044421,GO:0044877,GO:0046872,GO:0048513,GO:0048519,GO:0048523,GO:0048589,GO:0048705,GO:0048731,GO:0048736,GO:0048856,GO:0050789,GO:0050794,GO:0051216,GO:0060173,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060538,GO:0060548,GO:0061061,GO:0061448,GO:0062023,GO:0065007,GO:0070161,GO:0071840,GO:0097159,GO:0097367,GO:0098868,GO:1901681 - 0.00001657 55.0
TLS1_k127_173669_0 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006719 576.0
TLS1_k127_173669_1 Aminotransferase class I and II K00812,K14260 - 2.6.1.1,2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 349.0
TLS1_k127_1765578_0 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 352.0
TLS1_k127_1765578_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000002464 244.0
TLS1_k127_1765578_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009628,GO:0009986,GO:0009987,GO:0009991,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030246,GO:0030247,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071496,GO:0071840,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.0000000000000000000000000000000000009655 146.0
TLS1_k127_1765578_3 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation - - - 0.0000001992 60.0
TLS1_k127_1769778_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 355.0
TLS1_k127_1769778_1 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000006148 182.0
TLS1_k127_1776928_0 Nacht domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 422.0
TLS1_k127_1776928_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000806 283.0
TLS1_k127_1776928_2 iron assimilation - - - 0.000000000000000000000000000000000000005113 154.0
TLS1_k127_1785246_0 MazG nucleotide pyrophosphohydrolase domain K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 300.0
TLS1_k127_1785246_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000003989 243.0
TLS1_k127_1785246_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.00000000000000000000538 94.0
TLS1_k127_1785356_0 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000002208 235.0
TLS1_k127_1785356_1 Cytidylyltransferase-like - - - 0.00000000000000000000000000000000000000001896 168.0
TLS1_k127_1785356_2 COG0859 ADP-heptose LPS heptosyltransferase K02841 - - 0.0000000000000000006141 96.0
TLS1_k127_1785356_3 - - - - 0.00000000000004385 73.0
TLS1_k127_180168_0 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 367.0
TLS1_k127_1802759_0 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 4.764e-302 953.0
TLS1_k127_1802759_1 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000002004 150.0
TLS1_k127_1807941_0 Belongs to the ClpA ClpB family K03696 - - 1.05e-285 898.0
TLS1_k127_1807941_1 von Willebrand factor, type A - - - 0.0000000000000000000000000000000000000000000001075 180.0
TLS1_k127_1807941_2 DinB family - - - 0.0000000000000000000000006492 109.0
TLS1_k127_1807941_3 Cold shock protein domain K03704 - - 0.0000000000000000000218 96.0
TLS1_k127_1811074_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 362.0
TLS1_k127_1811074_1 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 348.0
TLS1_k127_1811074_2 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008544 323.0
TLS1_k127_1811074_3 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000006634 235.0
TLS1_k127_1811074_4 Cyclopropane fatty acid synthase and related methyltransferases - - - 0.00000000000284 74.0
TLS1_k127_1836468_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001631 289.0
TLS1_k127_1836468_1 Histidine kinase K07704 - 2.7.13.3 0.0000000000000000000000000000000000000000001898 179.0
TLS1_k127_1836468_2 LytTr DNA-binding domain K02477 - - 0.0000000000000000000000000000000000000000002608 169.0
TLS1_k127_1858220_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006104 467.0
TLS1_k127_1858220_1 Domain of unknown function (DUF4440) - - - 0.0005415 49.0
TLS1_k127_1861840_0 Eco57I restriction-modification methylase K07317 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008474 386.0
TLS1_k127_1861840_1 BsuBI/PstI restriction endonuclease C-terminus K07317 - 2.1.1.72 0.00000000000000000000000000000000000000000001051 173.0
TLS1_k127_1861840_2 CHAT domain - - - 0.00000000000000894 89.0
TLS1_k127_1864631_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 320.0
TLS1_k127_1864631_1 helix_turn_helix, Arsenical Resistance Operon Repressor - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010288,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032791,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046870,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097063,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000008506 237.0
TLS1_k127_1864636_0 Anaphase-promoting complex subunit 5 - - - 7.104e-214 705.0
TLS1_k127_1864636_1 IgA Peptidase M64 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 483.0
TLS1_k127_1864636_2 NAD(P)H dehydrogenase (quinone) activity - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008483,GO:0009987,GO:0016740,GO:0016769,GO:0016999,GO:0017144,GO:0044237 - 0.000000000000000000000000000000000000000000000000000000000000000004375 232.0
TLS1_k127_1864636_3 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000002004 200.0
TLS1_k127_1864636_4 - - - - 0.0000000000000000000001904 110.0
TLS1_k127_1864636_5 - - - - 0.00000000004904 66.0
TLS1_k127_1868532_0 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000734 214.0
TLS1_k127_1868532_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000001446 156.0
TLS1_k127_1868532_2 - - - - 0.0000000000000000000000001587 108.0
TLS1_k127_1868532_3 Ribonuclease K01167 - 3.1.27.3 0.0000000000000002523 79.0
TLS1_k127_1875440_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 328.0
TLS1_k127_1875440_1 lipoprotein localization to outer membrane K02004 - - 0.00000000000000000000000000000000000000000000000000002081 198.0
TLS1_k127_1882867_0 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008921 272.0
TLS1_k127_1882867_1 PD-(D/E)XK nuclease superfamily - - - 0.0000000688 62.0
TLS1_k127_190072_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 1.545e-198 649.0
TLS1_k127_1908252_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000002868 126.0
TLS1_k127_1908252_1 O-Antigen ligase K18814 - - 0.0000000000000000000000005705 119.0
TLS1_k127_1908252_2 PFAM glycosyl transferase group 1 - - - 0.000000000003643 78.0
TLS1_k127_1908252_3 Trm112p-like protein K09791 - - 0.00000000104 65.0
TLS1_k127_1908252_4 Putative adhesin - - - 0.00006638 55.0
TLS1_k127_1908252_5 AntiSigma factor - - - 0.0007534 52.0
TLS1_k127_1913974_0 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 579.0
TLS1_k127_1913974_1 Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000004078 216.0
TLS1_k127_1913974_2 Domain of unknown function (DU1801) - - - 0.00000000000000000000000002594 110.0
TLS1_k127_1929937_0 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 329.0
TLS1_k127_1929937_1 Belongs to the SUA5 family K07566 - 2.7.7.87 0.00000000000000000000000000006968 124.0
TLS1_k127_1929937_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000007679 76.0
TLS1_k127_1937075_0 response regulator K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 514.0
TLS1_k127_1937075_1 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 368.0
TLS1_k127_1937075_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 368.0
TLS1_k127_1937075_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002246 278.0
TLS1_k127_1937075_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000005713 182.0
TLS1_k127_1937075_5 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000008999 199.0
TLS1_k127_1937075_6 - - - - 0.0000000000000000000000000000000000000000000003937 170.0
TLS1_k127_1937075_7 Protein of unknown function (DUF2971) - - - 0.00000000001514 76.0
TLS1_k127_1937075_8 Domain of unknown function (DUF4390) - - - 0.000000395 61.0
TLS1_k127_1939313_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 449.0
TLS1_k127_1939313_1 Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001002 292.0
TLS1_k127_1939313_2 thiolester hydrolase activity K06889 - - 0.0000000000000000000000000000000000000000003012 171.0
TLS1_k127_1946212_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007403 317.0
TLS1_k127_1946212_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008912 268.0
TLS1_k127_1965254_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 7.731e-305 954.0
TLS1_k127_1965254_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 8.782e-200 636.0
TLS1_k127_1965254_10 Belongs to the 'phage' integrase family K04763 - - 0.0001018 47.0
TLS1_k127_1965254_11 Domain of unknown function (DUF2019) - - - 0.0004861 48.0
TLS1_k127_1965254_2 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 349.0
TLS1_k127_1965254_3 Amidinotransferase K01478 - 3.5.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 352.0
TLS1_k127_1965254_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000006021 184.0
TLS1_k127_1965254_5 BioY family K03523 - - 0.000000000000000000000000000000001633 144.0
TLS1_k127_1965254_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000001999 118.0
TLS1_k127_1965254_7 - - - - 0.00000000000000005004 91.0
TLS1_k127_1965254_9 - - - - 0.000000001683 65.0
TLS1_k127_1968939_0 MgsA AAA+ ATPase C terminal K07478 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 470.0
TLS1_k127_1968939_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 315.0
TLS1_k127_1968939_2 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - 0.0000000000000000000000000000000000000000000000002076 196.0
TLS1_k127_1968939_3 Thioesterase superfamily K10806 - - 0.0000000000000000000000000000002634 127.0
TLS1_k127_1968939_4 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.000000000000003778 86.0
TLS1_k127_1976014_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 561.0
TLS1_k127_1976014_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000008649 123.0
TLS1_k127_1976014_2 PFAM helix-turn-helix, Fis-type - - - 0.000003034 53.0
TLS1_k127_1976069_0 Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family K03455 - - 4.391e-251 785.0
TLS1_k127_1976069_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 317.0
TLS1_k127_1976069_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000345 243.0
TLS1_k127_1976069_3 MacB-like periplasmic core domain - - - 0.000000000005186 75.0
TLS1_k127_197984_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002805 286.0
TLS1_k127_1985885_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 6.489e-266 832.0
TLS1_k127_1985885_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.00000000000000000000000000000000000000000000000747 175.0
TLS1_k127_1985885_2 Low affinity iron permease - - - 0.0000000000000000000000000000000000000000107 163.0
TLS1_k127_1985885_3 SnoaL-like domain - - - 0.000000000000000000000002264 114.0
TLS1_k127_1985885_4 Plasmid stability protein K21495 - - 0.00000000009656 67.0
TLS1_k127_1988823_0 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000006128 256.0
TLS1_k127_1988823_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000803 270.0
TLS1_k127_1988823_2 DNA-damage-inducible protein d K14623 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000000027 230.0
TLS1_k127_1988823_3 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000000000345 182.0
TLS1_k127_1988823_4 YigZ family - - - 0.000000000000000000000000000000002198 139.0
TLS1_k127_1990568_0 CO dehydrogenase flavoprotein C-terminal domain K13481 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 388.0
TLS1_k127_1991468_0 B-1 B cell differentiation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007434 268.0
TLS1_k127_1991468_1 Tetratricopeptide repeat - - - 0.00000000000000000000000001292 126.0
TLS1_k127_1999421_0 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000001839 161.0
TLS1_k127_2016039_0 Protein of unknown function (DUF2723) - - - 0.00000000003804 74.0
TLS1_k127_201902_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 357.0
TLS1_k127_201902_1 Protein of unknown function (DUF433) - - - 0.000000000000000001244 88.0
TLS1_k127_201902_2 Photosynthetic reaction centre cytochrome C subunit - - - 0.000000000000001191 83.0
TLS1_k127_201902_3 - - - - 0.000000001549 64.0
TLS1_k127_201902_4 Lipopolysaccharide-assembly, LptC-related - - - 0.00003155 55.0
TLS1_k127_201902_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0007322 46.0
TLS1_k127_2019812_0 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 484.0
TLS1_k127_2019812_1 NHL repeat - - - 0.00000000000002402 87.0
TLS1_k127_2019812_2 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0001951 44.0
TLS1_k127_2027183_0 PFAM Restriction endonuclease, type I, R subunit Type III, Res subunit K01156 - 3.1.21.5 8.291e-282 889.0
TLS1_k127_2027183_1 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 6.404e-269 844.0
TLS1_k127_2027183_10 Formyl transferase, C-terminal domain - - - 0.0000000000005302 79.0
TLS1_k127_2027183_11 Sigma-70 region 2 K03088 - - 0.0000005619 53.0
TLS1_k127_2027183_12 Methyltransferase type 11 - - - 0.000008074 58.0
TLS1_k127_2027183_2 PFAM DNA methylase N-4 N-6 K00571,K07316 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 593.0
TLS1_k127_2027183_3 Phage integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000003749 234.0
TLS1_k127_2027183_4 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000003879 222.0
TLS1_k127_2027183_5 Belongs to the sigma-70 factor family K03088 - - 0.000000000000000000000000000000000000000692 152.0
TLS1_k127_2027183_7 Hexapeptide repeat of succinyl-transferase K02536 - 2.3.1.191 0.0000000000000000000000000000000008454 143.0
TLS1_k127_2027183_8 Peptidase family S41 - - - 0.00000000000000000000000000001524 129.0
TLS1_k127_2027183_9 glyoxalase III activity - - - 0.00000000000000000000000000001614 130.0
TLS1_k127_2028445_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 327.0
TLS1_k127_2028445_1 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.000000000000000000000000000000000000009714 153.0
TLS1_k127_2028445_2 Histidine kinase - - - 0.00000000000005212 86.0
TLS1_k127_2034318_0 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001707 239.0
TLS1_k127_2034318_1 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000001144 144.0
TLS1_k127_2034318_2 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.00000000000000000000000000000000463 138.0
TLS1_k127_2035959_0 ABC transporter K06020 - 3.6.3.25 9.895e-289 893.0
TLS1_k127_2035959_1 TonB-dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 323.0
TLS1_k127_2035959_2 phosphoserine phosphatase activity K07052,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000004278 203.0
TLS1_k127_2043055_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 473.0
TLS1_k127_2043055_1 PFAM AMP-dependent synthetase and ligase K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 451.0
TLS1_k127_2043055_2 TonB-dependent Receptor Plug Domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 394.0
TLS1_k127_2043055_3 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002909 301.0
TLS1_k127_2043055_4 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002722 286.0
TLS1_k127_2043055_5 Alpha/beta hydrolase family - - - 0.000000000000000000000000000001634 131.0
TLS1_k127_2043055_6 transcriptional regulator, TetR family K22108 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0042803,GO:0046983,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000004026 74.0
TLS1_k127_2058203_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000001791 164.0
TLS1_k127_2058203_1 Bacterial regulatory protein, Fis family K02584 - - 0.000000000000000000000000000000005038 149.0
TLS1_k127_2068533_0 DEAD DEAH box K03724 - - 2.868e-226 711.0
TLS1_k127_2084220_0 protein secretion by the type I secretion system K11085 - - 1.503e-229 724.0
TLS1_k127_2084220_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 330.0
TLS1_k127_2084220_2 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007964 324.0
TLS1_k127_2084220_3 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005531 277.0
TLS1_k127_2084220_4 ATP-independent chaperone mediated protein folding K06006 - - 0.000000002931 65.0
TLS1_k127_2087409_0 AhpC/TSA family - - - 0.00000000000000000000000000000000000000000000000004793 190.0
TLS1_k127_2087409_1 - - - - 0.000000000000000000000001357 107.0
TLS1_k127_2087409_2 Protein of unknown function (DUF433) - - - 0.00000000000000000000000466 105.0
TLS1_k127_2087409_3 - - - - 0.0008117 51.0
TLS1_k127_2091110_0 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000985 387.0
TLS1_k127_2091110_1 Two component transcriptional regulator, winged helix family K07670 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000007754 62.0
TLS1_k127_2091110_2 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.0009448 50.0
TLS1_k127_2093464_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008706 438.0
TLS1_k127_2093464_1 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000001624 189.0
TLS1_k127_2093464_2 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000009521 164.0
TLS1_k127_2093464_3 cheY-homologous receiver domain - - - 0.00000000000000007296 86.0
TLS1_k127_2100351_0 PFAM Copper type II ascorbate-dependent monooxygenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 389.0
TLS1_k127_2100351_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000000000000001022 242.0
TLS1_k127_2100351_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000003867 119.0
TLS1_k127_2105627_0 L-asparaginase II - - - 0.000000000000000000000000000000000000000000000000212 186.0
TLS1_k127_2105627_1 Thioredoxin-like domain - - - 0.0000000000000003718 90.0
TLS1_k127_2105627_2 L-asparaginase II K01424 - 3.5.1.1 0.000004253 54.0
TLS1_k127_2105627_3 Rhodanese Homology Domain - - - 0.000004756 56.0
TLS1_k127_2118089_0 sigma factor activity K02405 - - 0.0000000000000000000000000001366 126.0
TLS1_k127_2118089_1 Tetratricopeptide repeat - - - 0.0000000000005309 83.0
TLS1_k127_2131183_0 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 366.0
TLS1_k127_2131183_1 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007535 303.0
TLS1_k127_2131183_2 N-Acetylmuramoyl-L-alanine amidase K13730 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 287.0
TLS1_k127_2131183_3 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000001013 239.0
TLS1_k127_2131183_4 PFAM Fibronectin type III domain - - - 0.0000000000000000000000000009467 133.0
TLS1_k127_2131183_6 Smr domain - - - 0.000000000000000000000171 101.0
TLS1_k127_2131183_7 Palmitoyl-monogalactosyldiacylglycerol delta-7 desaturase, chloroplastic-like K20416 - 1.14.19.42 0.0000008603 53.0
TLS1_k127_2148216_0 - K17831 GO:0001716,GO:0001906,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016641,GO:0031640,GO:0033736,GO:0035821,GO:0043900,GO:0043901,GO:0044364,GO:0044419,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:1900190,GO:1900191 1.4.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 479.0
TLS1_k127_2148216_1 Type I restriction enzyme R protein N terminus (HSDR_N) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 298.0
TLS1_k127_2148216_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001371 279.0
TLS1_k127_2148216_3 - - - - 0.0000000000000000000000007364 112.0
TLS1_k127_2150552_0 Ferritin-like K20087 - - 0.000000000000000000000000000000000000000000000000000000000000000000051 257.0
TLS1_k127_2150552_1 GAF domain - - - 0.0000000000000000000000000000000000000000000002515 170.0
TLS1_k127_2163653_0 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000005964 190.0
TLS1_k127_2163653_1 Belongs to the peptidase S8 family - - - 0.00000000000000000001282 108.0
TLS1_k127_2163653_2 - - - - 0.0000000001239 72.0
TLS1_k127_2165593_0 FAD linked oxidases, C-terminal domain K06911 - - 0.0 1221.0
TLS1_k127_2165593_1 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 453.0
TLS1_k127_2165593_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 434.0
TLS1_k127_2165593_3 Nucleotidyl transferase of unknown function (DUF2204) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 312.0
TLS1_k127_2165593_4 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004611 274.0
TLS1_k127_2165593_5 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000007437 237.0
TLS1_k127_2165593_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002233 235.0
TLS1_k127_2165593_7 Predicted membrane protein (DUF2231) - - - 0.0000000000000000000000000000000000000003715 160.0
TLS1_k127_2165593_8 - K01992,K19341 - - 0.000000000000000000000000000000001885 145.0
TLS1_k127_2165593_9 PFAM Stress-induced bacterial acidophilic repeat motif K06884 - - 0.000000000000000000000004276 107.0
TLS1_k127_2187480_0 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 568.0
TLS1_k127_2187480_1 site-specific DNA-methyltransferase (adenine-specific) activity K03427 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 576.0
TLS1_k127_2187480_10 Polysaccharide biosynthesis protein - - - 0.00000000000882 72.0
TLS1_k127_2187480_11 - - - - 0.00000001949 63.0
TLS1_k127_2187480_12 KR domain - - - 0.0000001748 61.0
TLS1_k127_2187480_13 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family K00362 - 1.7.1.15 0.00001727 54.0
TLS1_k127_2187480_14 - - - - 0.0001189 50.0
TLS1_k127_2187480_15 acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658 - 2.3.1.12,2.3.1.61 0.0002844 47.0
TLS1_k127_2187480_2 Fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 392.0
TLS1_k127_2187480_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000469 233.0
TLS1_k127_2187480_4 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000003655 228.0
TLS1_k127_2187480_5 conserved protein (DUF2267) - - - 0.000000000000000000000001072 108.0
TLS1_k127_2187480_6 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.00000000000000000000001206 110.0
TLS1_k127_2187480_7 Belongs to the universal stress protein A family - - - 0.0000000000000000000002958 108.0
TLS1_k127_2187480_8 - catabolite gene activator and regulatory subunit of cAMP-dependent protein K10914 - - 0.0000000000000001892 90.0
TLS1_k127_2187480_9 ArsC family K16509 - - 0.000000000001109 71.0
TLS1_k127_2206672_0 Binding-protein-dependent transport system inner membrane component K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 425.0
TLS1_k127_2206672_1 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 414.0
TLS1_k127_2208923_0 SpoIVB peptidase S55 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 311.0
TLS1_k127_2208923_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001503 298.0
TLS1_k127_2213133_0 Outer membrane receptor for ferrienterochelin and colicins - - - 4.993e-272 870.0
TLS1_k127_2213133_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 451.0
TLS1_k127_2221147_0 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001364 265.0
TLS1_k127_2221147_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000004079 210.0
TLS1_k127_2221147_2 radical SAM domain protein - - - 0.000000000007323 78.0
TLS1_k127_2221147_3 Glycosyl transferases group 1 - - - 0.00000008801 64.0
TLS1_k127_2221437_0 MCM2/3/5 family K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 324.0
TLS1_k127_2221437_1 - - - - 0.0001261 51.0
TLS1_k127_2221457_0 Peptidase M15 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 334.0
TLS1_k127_2221457_1 Hemerythrin hhe cation binding - - - 0.00000000000000000000000000000000000000595 150.0
TLS1_k127_2221457_3 von Willebrand factor, type A - - - 0.0000000000000001356 89.0
TLS1_k127_2222712_0 Phosphatase K01090 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 438.0
TLS1_k127_2222712_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 342.0
TLS1_k127_2225688_0 Penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 451.0
TLS1_k127_2225688_1 Transposase IS200 like - - - 0.000000000000000000000000000000000000000000000000000000000000001364 233.0
TLS1_k127_2247887_0 ATPase domain of DNA mismatch repair MUTS family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 492.0
TLS1_k127_2247887_1 Protein of unknown function (DUF962) - - - 0.000000000000000000002405 101.0
TLS1_k127_2247887_2 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000955 96.0
TLS1_k127_2247887_3 two component, sigma54 specific, transcriptional regulator, Fis family K07714 - - 0.0000000000000001152 85.0
TLS1_k127_2248238_0 S-adenosylmethionine synthetase, C-terminal domain K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 523.0
TLS1_k127_2248238_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000005029 63.0
TLS1_k127_2257516_0 Belongs to the glycosyl hydrolase 57 family - - - 1.572e-260 820.0
TLS1_k127_2257516_1 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000005516 200.0
TLS1_k127_2257516_2 two component, sigma54 specific, transcriptional regulator, Fis family K07713 - - 0.000000000009018 71.0
TLS1_k127_2262055_0 protein involved in exopolysaccharide biosynthesis K16554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 310.0
TLS1_k127_2262055_1 - - - - 0.000003649 57.0
TLS1_k127_2262055_2 PFAM Glycosyl transferases group 1 - - - 0.000686 44.0
TLS1_k127_2263340_0 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002119 259.0
TLS1_k127_2263340_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000006015 100.0
TLS1_k127_2263370_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 0.0000000000000000000000000000000000000000000000000000000000000000000000897 255.0
TLS1_k127_2263370_1 regulation of translation K03530 - - 0.000000000000000000000000003097 116.0
TLS1_k127_2263370_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000002293 103.0
TLS1_k127_2269040_0 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000003027 194.0
TLS1_k127_2269040_1 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000006093 134.0
TLS1_k127_2269040_2 PAP2 superfamily - - - 0.00000000000000001647 94.0
TLS1_k127_2271982_0 Branched-chain amino acid transport system / permease component K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006062 332.0
TLS1_k127_2271982_1 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 316.0
TLS1_k127_2271982_2 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000398 288.0
TLS1_k127_2271982_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000002885 181.0
TLS1_k127_2271982_4 Putative addiction module component - - - 0.0007747 43.0
TLS1_k127_227362_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 458.0
TLS1_k127_227362_1 histidyl-tRNA synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000008358 234.0
TLS1_k127_227362_2 PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K07303 - 1.3.99.16 0.000000000000000000000000000000000000002346 149.0
TLS1_k127_2289477_0 4Fe-4S dicluster domain K00184 - - 0.0 1037.0
TLS1_k127_2289477_1 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 299.0
TLS1_k127_2289477_2 COG1404 Subtilisin-like serine proteases K14645 GO:0005575,GO:0005576 - 0.00000000000000000000000000000000000000000001494 186.0
TLS1_k127_2289477_3 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000009528 160.0
TLS1_k127_2289477_4 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.00000000000000000000007334 115.0
TLS1_k127_2289477_5 ChrR Cupin-like domain - - - 0.000000000003915 73.0
TLS1_k127_2294855_0 Y_Y_Y domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 604.0
TLS1_k127_2294855_1 Sigma-70 region 2 K03088 - - 0.000000003048 65.0
TLS1_k127_2294855_2 Tetratricopeptide repeat - - - 0.000002414 60.0
TLS1_k127_2296709_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 357.0
TLS1_k127_2296709_1 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001693 258.0
TLS1_k127_2296831_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006935 520.0
TLS1_k127_2296831_1 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity K07471,K13652,K19056 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000001012 230.0
TLS1_k127_2296831_2 Nucleotidyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000128 230.0
TLS1_k127_2296831_3 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000003486 198.0
TLS1_k127_2296831_4 FR47-like protein - - - 0.00000000000000000000000000000000004362 139.0
TLS1_k127_2296831_5 Nacht domain - - - 0.0000000000000000003824 104.0
TLS1_k127_2296831_6 Belongs to the UPF0758 family K03630 - - 0.00000003189 60.0
TLS1_k127_2296831_7 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.0000001212 58.0
TLS1_k127_2311246_0 Common central domain of tyrosinase K00422,K00505 - 1.10.3.1,1.14.18.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 456.0
TLS1_k127_2311246_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 321.0
TLS1_k127_2311246_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000001033 113.0
TLS1_k127_2316471_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008355 562.0
TLS1_k127_2316471_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000007279 265.0
TLS1_k127_2316471_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000002586 218.0
TLS1_k127_2316471_3 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000003144 192.0
TLS1_k127_2316471_4 synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000001916 168.0
TLS1_k127_2316471_5 Protein tyrosine kinase - - - 0.000000000000000000000000003432 130.0
TLS1_k127_2316471_6 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000001575 83.0
TLS1_k127_2316471_7 Biotin-requiring enzyme - - - 0.000000000000001724 87.0
TLS1_k127_2326590_0 Cytochrome c-type biogenesis protein K02198 - - 1.986e-197 639.0
TLS1_k127_2326590_1 Redoxin K02199 - - 0.0000000000000000000000000000000000000000000001063 173.0
TLS1_k127_2326590_2 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000002521 140.0
TLS1_k127_2326590_4 subunit of a heme lyase K02200 - - 0.000000000000000000001128 101.0
TLS1_k127_2326590_5 peptidyl-tyrosine sulfation - - - 0.0005947 49.0
TLS1_k127_2334443_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 390.0
TLS1_k127_2334443_1 U mismatch-specific DNA glycosylase K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000000000000000000000002916 246.0
TLS1_k127_2334443_2 Signal transduction protein with Nacht domain - - - 0.000000000002506 81.0
TLS1_k127_2352091_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 609.0
TLS1_k127_2352091_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 475.0
TLS1_k127_2352091_2 COG1192 ATPases involved in chromosome partitioning K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 308.0
TLS1_k127_2352091_3 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 309.0
TLS1_k127_2352091_4 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000005672 243.0
TLS1_k127_2352091_5 Polymer-forming cytoskeletal - - - 0.0000000000000000000000003837 109.0
TLS1_k127_2352091_6 Putative zinc- or iron-chelating domain - - - 0.000000000000000001708 94.0
TLS1_k127_2352091_7 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000001245 87.0
TLS1_k127_2352091_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000001648 83.0
TLS1_k127_2352091_9 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.0000000003905 70.0
TLS1_k127_2365912_0 FIST C domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 415.0
TLS1_k127_2365912_1 histidine kinase A domain protein domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006708 281.0
TLS1_k127_2365912_2 PFAM Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000000000000006484 232.0
TLS1_k127_2374828_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005611 528.0
TLS1_k127_2374828_1 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 293.0
TLS1_k127_2374828_3 - - - - 0.00000000000000009186 93.0
TLS1_k127_2388130_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 389.0
TLS1_k127_2388130_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000001059 209.0
TLS1_k127_2406499_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003384 589.0
TLS1_k127_2406499_1 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009994 289.0
TLS1_k127_2406499_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000001766 196.0
TLS1_k127_2406499_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000001163 184.0
TLS1_k127_2406499_4 Histidine triad (HIT) protein K02503 - - 0.00000000000000000000000000000000000008235 150.0
TLS1_k127_2406499_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000003408 76.0
TLS1_k127_2406499_6 ASCH - - - 0.00000536 54.0
TLS1_k127_2406499_7 Ribosomal-protein-alanine acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 0.00002835 52.0
TLS1_k127_2406499_9 - - - - 0.0001539 53.0
TLS1_k127_241675_0 Adenosine/AMP deaminase - - - 3.956e-211 669.0
TLS1_k127_241675_1 Winged helix DNA-binding domain K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 453.0
TLS1_k127_241675_2 Belongs to the Nudix hydrolase family K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 309.0
TLS1_k127_241675_3 Sigma-70 region 2 - - - 0.0002483 50.0
TLS1_k127_2419123_0 Parallel beta-helix repeats - - - 0.0000000001306 74.0
TLS1_k127_2422456_0 integrase domain protein SAM domain protein K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000006689 239.0
TLS1_k127_2422456_1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000000000000004354 153.0
TLS1_k127_2422456_2 TonB dependent receptor K16087 - - 0.000000000000008259 86.0
TLS1_k127_2425088_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 350.0
TLS1_k127_2425088_1 - - - - 0.000000000000000000000000000000000000000000000001057 179.0
TLS1_k127_2425088_2 CopG antitoxin of type II toxin-antitoxin system - - - 0.0000000000000000000000000000000000003065 142.0
TLS1_k127_2425088_3 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000000002516 125.0
TLS1_k127_2425088_4 Cbs domain K04767 - - 0.00000000000002355 78.0
TLS1_k127_2425088_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000005429 66.0
TLS1_k127_2433175_0 sequence-specific DNA binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 508.0
TLS1_k127_2433175_1 methyltransferase activity - - - 0.00000000000000000000000000000004617 130.0
TLS1_k127_2462139_0 Histidine kinase K20971,K20974 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 378.0
TLS1_k127_2462139_1 cheY-homologous receiver domain - - - 0.0000000000000000000000000000001339 137.0
TLS1_k127_2462209_0 cellulose binding - - - 0.0 1169.0
TLS1_k127_2462209_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1095.0
TLS1_k127_2462209_2 KAP family P-loop domain - - - 0.0000000000000000000000000000000006215 147.0
TLS1_k127_2473781_0 AAA domain K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 338.0
TLS1_k127_2473781_1 Heat shock protein DnaJ domain protein - - - 0.00000000000000000000000000000000000000000000000000000000003457 220.0
TLS1_k127_2473781_2 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000003504 108.0
TLS1_k127_2473781_3 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.00000000000000005506 85.0
TLS1_k127_2473924_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006509 593.0
TLS1_k127_2473924_1 Belongs to the phosphoglycerate mutase family K02226,K22305 - 3.1.3.3,3.1.3.73 0.000000000000000000000000006018 117.0
TLS1_k127_2473949_0 -O-antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 388.0
TLS1_k127_2479421_0 halogenase K14257 - 1.14.19.49 6.997e-259 811.0
TLS1_k127_2479421_1 Transglycosylase associated protein - - - 0.000000000005467 70.0
TLS1_k127_2489360_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000002721 140.0
TLS1_k127_2489360_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000005684 59.0
TLS1_k127_2494766_0 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 365.0
TLS1_k127_2494766_1 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000000000000001484 185.0
TLS1_k127_2494766_2 Universal stress protein K06149 - - 0.000000000000000003763 95.0
TLS1_k127_2515593_0 Right handed beta helix region - - - 0.000000000000000000000000000000000000000000000317 190.0
TLS1_k127_2515593_1 PFAM Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000000001486 152.0
TLS1_k127_2515593_2 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0000000000000000000000000000000008484 139.0
TLS1_k127_2544841_0 helix_turn_helix, Lux Regulon K07693 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 300.0
TLS1_k127_2544841_1 Histidine kinase K07778 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 296.0
TLS1_k127_2544841_2 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 285.0
TLS1_k127_2544841_3 ABC-2 type transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002263 277.0
TLS1_k127_2546335_0 Peptidase S46 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008487 446.0
TLS1_k127_2546335_1 GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 454.0
TLS1_k127_2551691_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000002985 259.0
TLS1_k127_2551691_1 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000001939 148.0
TLS1_k127_2555348_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 389.0
TLS1_k127_2555348_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 338.0
TLS1_k127_2555348_2 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000004514 260.0
TLS1_k127_2555348_3 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000007861 233.0
TLS1_k127_2555348_4 nucleic acid-binding protein contains PIN domain - - - 0.000000000000000000000004051 106.0
TLS1_k127_2555348_5 protein secretion K03116,K03117,K03425 GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000003725 65.0
TLS1_k127_255772_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 6.628e-201 638.0
TLS1_k127_255772_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004356 342.0
TLS1_k127_255772_2 Beta-eliminating lyase K01668 - 4.1.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008598 295.0
TLS1_k127_255772_3 TIGRFAM channel protein, hemolysin III family K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002767 273.0
TLS1_k127_255772_4 Rubrerythrin - - - 0.0000000000000000002269 95.0
TLS1_k127_255772_5 Sugar efflux transporter for intercellular exchange K15383 - - 0.00000000000000002367 85.0
TLS1_k127_255772_6 Beta-eliminating lyase K01668 - 4.1.99.2 0.000000000001348 67.0
TLS1_k127_255772_7 Sulfite exporter TauE/SafE K07090 - - 0.000000000001978 76.0
TLS1_k127_2580012_0 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 442.0
TLS1_k127_2580012_1 Transcriptional regulator (AsnC family) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 326.0
TLS1_k127_2580012_2 peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000001053 185.0
TLS1_k127_2580012_3 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.000000000000000000000000000000001464 142.0
TLS1_k127_2580012_4 Domain of unknown function (DUF309) K09763 - - 0.00000000001047 76.0
TLS1_k127_2580139_0 PFAM Glucose Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 434.0
TLS1_k127_2580139_1 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000009656 184.0
TLS1_k127_258835_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 565.0
TLS1_k127_258835_1 Thermolysin metallopeptidase, catalytic domain - - - 0.00000000000000000000000000001609 135.0
TLS1_k127_2597445_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 392.0
TLS1_k127_2597445_1 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000002298 253.0
TLS1_k127_2597445_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0002224 46.0
TLS1_k127_2598420_0 Outer membrane receptor - - - 2.943e-225 729.0
TLS1_k127_2598420_1 LacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 342.0
TLS1_k127_2609054_0 Uncharacterized conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000000000002824 226.0
TLS1_k127_2609054_1 Glycosyl transferase, family 2 K13693 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006011,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009225,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0034641,GO:0040007,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046983,GO:0055086,GO:0071704,GO:1901135,GO:1901360 2.4.1.266 0.00000000000000000000000000000000007071 144.0
TLS1_k127_2609054_2 Late embryogenesis abundant protein - - - 0.00000000493 66.0
TLS1_k127_2639584_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 548.0
TLS1_k127_2639584_1 Peptidase S46 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 400.0
TLS1_k127_2645247_0 Nucleotidyl transferase K04042,K11528 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000934 458.0
TLS1_k127_2645247_1 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 305.0
TLS1_k127_2645247_2 gag-polyprotein putative aspartyl protease K06985 - - 0.00009445 54.0
TLS1_k127_2652196_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 1.629e-213 669.0
TLS1_k127_2652196_1 Belongs to the malate synthase family K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 594.0
TLS1_k127_2652196_2 Domain of unknown function (DUF3520) K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 512.0
TLS1_k127_2652196_3 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000001987 226.0
TLS1_k127_2652196_4 protein conserved in bacteria - - - 0.00000000000000000000000002027 116.0
TLS1_k127_2652196_5 Involved in the tonB-independent uptake of proteins K03641,K07277 - - 0.00000000000234 69.0
TLS1_k127_26558_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008716 496.0
TLS1_k127_26558_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 422.0
TLS1_k127_26558_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001413 284.0
TLS1_k127_2657745_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01537 - 3.6.3.8 0.0 1256.0
TLS1_k127_2657745_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 353.0
TLS1_k127_2657745_2 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001715 271.0
TLS1_k127_2657745_3 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000004217 241.0
TLS1_k127_2657745_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000213 243.0
TLS1_k127_2657745_5 - - - - 0.0000000000000000000000004303 115.0
TLS1_k127_2657966_0 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006626 370.0
TLS1_k127_2657966_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 289.0
TLS1_k127_2657966_2 - K07112 - - 0.0000000003311 63.0
TLS1_k127_2658571_0 NAD-specific glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1095.0
TLS1_k127_2661116_0 Proteasomal ATPase OB/ID domain K13527 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 384.0
TLS1_k127_2661116_1 PFAM Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001729 265.0
TLS1_k127_2661116_2 PFAM Binding-protein-dependent transport system inner membrane component K05846 - - 0.000000000000000000000000000000000000000000000000000000008345 205.0
TLS1_k127_2661116_3 Pup-ligase protein K20814 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 0.000000000000000000000000000000000000006265 154.0
TLS1_k127_2661177_0 LAO AO transport system K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 321.0
TLS1_k127_2661177_1 Domain of unknown function (DUF4160) - - - 0.00000000000000000000003887 100.0
TLS1_k127_2661177_2 Protein of unknown function (DUF2442) - - - 0.000000000000000000003466 96.0
TLS1_k127_2675752_0 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000001594 220.0
TLS1_k127_2675752_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000352 173.0
TLS1_k127_2675752_2 Catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis K01933 - 6.3.3.1 0.00000000000000000000000000000000001623 139.0
TLS1_k127_2675752_3 Allophanate hydrolase subunit 2 - - - 0.000000000000000000000000000000001651 148.0
TLS1_k127_2684801_0 Pfam Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 404.0
TLS1_k127_2685891_0 transferase activity, transferring acyl groups - - - 0.00000000000000000002146 103.0
TLS1_k127_2685891_1 Integral membrane sensor hybrid histidine kinase - - - 0.00000000000000000009988 95.0
TLS1_k127_2685891_2 Methyltransferase domain - - - 0.0000000000000844 74.0
TLS1_k127_2685891_3 methyltransferase - - - 0.0000000008496 70.0
TLS1_k127_2689798_0 AlkA N-terminal domain K13529 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000003421 204.0
TLS1_k127_2689798_1 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000005674 176.0
TLS1_k127_2689798_2 PIN domain K18828 - - 0.000000000000000000000000000008087 123.0
TLS1_k127_2689798_3 Protein of unknown function (DUF664) - - - 0.0000000000000000008306 95.0
TLS1_k127_2689798_4 SpoVT / AbrB like domain K18829 - - 0.0000006536 54.0
TLS1_k127_2689798_5 protein conserved in bacteria K09924 - - 0.00001418 55.0
TLS1_k127_2689798_6 antibiotic catabolic process - - - 0.0000779 56.0
TLS1_k127_2692717_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 435.0
TLS1_k127_2692717_1 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - 0.00000000000000000000000000000000000000000000000000000000000000001053 250.0
TLS1_k127_2692717_2 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000002365 222.0
TLS1_k127_2692717_3 Lecithin:cholesterol acyltransferase - - - 0.00000000000000000000000000000000000000000000000000001173 209.0
TLS1_k127_269567_0 - - - - 0.00000000000000000000517 108.0
TLS1_k127_2697220_0 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 595.0
TLS1_k127_2697220_1 Signal Transduction Histidine Kinase - - - 0.0000000000000000000000000000000000000000000000000000000000002289 222.0
TLS1_k127_270345_0 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 445.0
TLS1_k127_270345_1 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008339 271.0
TLS1_k127_270345_10 zinc-ribbon domain - - - 0.0000001532 61.0
TLS1_k127_270345_11 Serine/Threonine protein kinases, catalytic domain K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.000005476 59.0
TLS1_k127_270345_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001141 261.0
TLS1_k127_270345_3 Peptidase family M20/M25/M40 - - - 0.0000000000000000000000000000000000000000007362 176.0
TLS1_k127_270345_4 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000001146 131.0
TLS1_k127_270345_5 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000006941 95.0
TLS1_k127_270345_6 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000001889 88.0
TLS1_k127_270345_7 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000001424 80.0
TLS1_k127_270345_8 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000007539 82.0
TLS1_k127_270345_9 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000008562 65.0
TLS1_k127_2719430_0 Saccharopine dehydrogenase K00290 - 1.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007389 343.0
TLS1_k127_2719430_1 curli production assembly transport component CsgG - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001343 275.0
TLS1_k127_2719430_2 Protein of unknown function (DUF692) K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003049 266.0
TLS1_k127_2719430_3 tRNA cytidylyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000002523 201.0
TLS1_k127_2719430_4 Cache domain - - - 0.00000000000000000000000000000000000000001006 166.0
TLS1_k127_2719430_5 Forkhead associated domain - - - 0.000000000004966 77.0
TLS1_k127_2719430_6 Helix-turn-helix XRE-family like proteins - - - 0.00001303 50.0
TLS1_k127_2719430_7 Transcriptional regulator - - - 0.0003507 45.0
TLS1_k127_2724335_0 Phospholipase D Transphosphatidylase K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000001731 233.0
TLS1_k127_2724335_1 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000002564 131.0
TLS1_k127_2724335_2 retrotransposable element Tf2 155 kDa protein type 1-like - - - 0.0007132 48.0
TLS1_k127_2737108_0 GAF domain K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 297.0
TLS1_k127_2737108_1 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008874 275.0
TLS1_k127_2741044_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006 - 2.7.9.1 6.436e-298 931.0
TLS1_k127_2741044_1 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 504.0
TLS1_k127_2741044_10 - - - - 0.00000000000000000000000000000000000000000001354 169.0
TLS1_k127_2741044_11 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000002454 169.0
TLS1_k127_2741044_12 Membrane-associated protein - - - 0.000000000000000000000000000000000705 138.0
TLS1_k127_2741044_13 Putative adhesin - - - 0.0000000000000000000000000000001306 136.0
TLS1_k127_2741044_14 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000001573 126.0
TLS1_k127_2741044_15 Protein of unknown function (DUF433) - - - 0.000000000000000000000004702 102.0
TLS1_k127_2741044_16 Glycosyl transferase, family 2 K16648,K20444 - - 0.000000000000000009331 97.0
TLS1_k127_2741044_18 - - - - 0.0000000004555 64.0
TLS1_k127_2741044_19 - - - - 0.0002431 53.0
TLS1_k127_2741044_2 Elongation factor SelB, winged helix K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006546 515.0
TLS1_k127_2741044_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 466.0
TLS1_k127_2741044_4 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 439.0
TLS1_k127_2741044_5 Pyridoxal-phosphate dependent enzyme K01738,K17216 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042127,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0065007,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.134,2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 347.0
TLS1_k127_2741044_6 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 305.0
TLS1_k127_2741044_7 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000649 272.0
TLS1_k127_2741044_8 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000003876 236.0
TLS1_k127_2741044_9 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000007256 190.0
TLS1_k127_2768330_0 DEAD/H associated K03724 - - 2.38e-271 861.0
TLS1_k127_2773993_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000009808 116.0
TLS1_k127_2773993_1 glycosyl transferase, family 2 - - - 0.00000000000005698 82.0
TLS1_k127_2783829_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 1.435e-298 927.0
TLS1_k127_2783829_1 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007044 285.0
TLS1_k127_2803842_0 surface antigen variable number - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001055 275.0
TLS1_k127_2803842_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000006565 124.0
TLS1_k127_2803842_2 Protein of unknown function (DUF962) - - - 0.0000000005747 64.0
TLS1_k127_2814546_0 Pyridoxal-dependent decarboxylase conserved domain K13745 - 4.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 322.0
TLS1_k127_2814546_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 287.0
TLS1_k127_2814546_2 Putative glycolipid-binding K09957 - - 0.00000000000000000000000000000000000000000000007131 175.0
TLS1_k127_2814546_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000001132 162.0
TLS1_k127_2814546_4 Domain of unknown function (DUF4388) - - - 0.0000000000000003216 85.0
TLS1_k127_2814866_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000287 168.0
TLS1_k127_2821734_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000004772 278.0
TLS1_k127_2821734_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.00000000000000000000000000000000000005406 147.0
TLS1_k127_2821734_2 TIGRFAM TonB family protein K03832 - - 0.0000000000000005041 90.0
TLS1_k127_2833640_0 Cytochrome c - - - 0.0 1133.0
TLS1_k127_2833640_1 GMC oxidoreductase - - - 8.532e-194 621.0
TLS1_k127_2833640_2 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 603.0
TLS1_k127_2833640_3 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008464 257.0
TLS1_k127_2833640_4 translation initiation factor activity K06996 - - 0.0000000000000000000000000000000000000000008816 159.0
TLS1_k127_2833640_5 Plasmid stabilization system - - - 0.0000000000000000005499 91.0
TLS1_k127_2833640_6 - - - - 0.000000000001807 68.0
TLS1_k127_2836824_0 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 287.0
TLS1_k127_2836824_1 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 302.0
TLS1_k127_2836824_2 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002713 254.0
TLS1_k127_2836824_3 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000001347 181.0
TLS1_k127_2836824_4 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000000000000000000027 173.0
TLS1_k127_2848883_0 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 386.0
TLS1_k127_2848883_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000008334 232.0
TLS1_k127_2848883_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K01760 - 4.4.1.8 0.000000000000000000000000004225 114.0
TLS1_k127_2848883_3 PFAM Methylamine - - - 0.00000000000000000006751 97.0
TLS1_k127_2848966_0 Belongs to the thiolase family K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 529.0
TLS1_k127_2848966_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008733 410.0
TLS1_k127_2848966_2 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 294.0
TLS1_k127_2848966_3 3-hydroxyacyl-CoA dehydrogenase domain protein K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000001082 256.0
TLS1_k127_285483_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 395.0
TLS1_k127_285483_1 Sugar (and other) transporter K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 298.0
TLS1_k127_285483_2 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.000000000000000000002928 98.0
TLS1_k127_285483_3 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.0001278 45.0
TLS1_k127_2859067_0 - - - - 0.000000000000000000000000000000000000000000000000002305 184.0
TLS1_k127_2859067_1 methyltransferase activity - - - 0.00000000000000000000000000000003725 140.0
TLS1_k127_2865865_0 Belongs to the ClpA ClpB family K03694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 406.0
TLS1_k127_2865865_1 Protein of unknown function (DUF2914) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009402 270.0
TLS1_k127_2865865_2 Methyltransferase domain - - - 0.0000000000000000000000000000001503 131.0
TLS1_k127_2865865_3 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000001202 117.0
TLS1_k127_2866447_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.336e-245 783.0
TLS1_k127_2866447_1 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002122 325.0
TLS1_k127_2877261_0 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000002032 154.0
TLS1_k127_2877261_1 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine K18911 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.1.44 0.0000000000000000000000000001444 126.0
TLS1_k127_2877261_2 HlyD family secretion protein - - - 0.0000000000000000000000001461 120.0
TLS1_k127_2888163_0 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 510.0
TLS1_k127_2888163_1 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 335.0
TLS1_k127_2888163_2 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.0000000000000000000000000000000000000000000000000000000000139 212.0
TLS1_k127_2888163_3 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000006041 176.0
TLS1_k127_2888163_4 DoxX K15977 - - 0.000000000000000000000000000000000000000000004121 166.0
TLS1_k127_2888363_0 COG0553 Superfamily II DNA RNA - - - 1.894e-228 746.0
TLS1_k127_2888363_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 597.0
TLS1_k127_2888363_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 578.0
TLS1_k127_2888363_3 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000005886 176.0
TLS1_k127_2888363_4 ATPase involved in DNA repair - - - 0.00000000000000000001015 99.0
TLS1_k127_2888363_5 Concanavalin A-like lectin/glucanases superfamily - - - 0.000000003846 70.0
TLS1_k127_2888544_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.492e-209 672.0
TLS1_k127_2888544_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 359.0
TLS1_k127_2888544_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 328.0
TLS1_k127_2888544_3 Platelet-activating factor acetylhydrolase, isoform II - - - 0.000000000000000000000000000000000000000000000000000000000000352 224.0
TLS1_k127_2888544_4 Multidrug transporter - - - 0.000000000000000000000000000000000000000000000000000005293 203.0
TLS1_k127_2888544_5 outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000001179 88.0
TLS1_k127_2888544_6 - - - - 0.000000000001547 74.0
TLS1_k127_2891706_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.344e-196 618.0
TLS1_k127_2891706_1 epimerase K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000001318 183.0
TLS1_k127_2904108_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1443.0
TLS1_k127_2904108_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 398.0
TLS1_k127_2904108_2 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009291 287.0
TLS1_k127_2904108_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002099 253.0
TLS1_k127_2904108_4 Domain of unknown function (DUF1287) K09974 - - 0.00000000000000000000000000000000000000000000000000000000000000000004829 237.0
TLS1_k127_2904108_6 Peptidase M56 - - - 0.0000000000002637 81.0
TLS1_k127_2904108_7 - - - - 0.00000001171 61.0
TLS1_k127_2904108_8 Putative addiction module component - - - 0.0000008224 59.0
TLS1_k127_2918069_0 Glycosyl transferase 4-like K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006705 311.0
TLS1_k127_2918069_1 transglycosylase K08309 - - 0.00000000000000000000000000004717 134.0
TLS1_k127_2919461_0 permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006811 610.0
TLS1_k127_2919461_1 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 393.0
TLS1_k127_2919461_2 Calx-beta domain - - - 0.000000003498 68.0
TLS1_k127_2921328_0 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 357.0
TLS1_k127_2921328_1 ADP-heptose-lipopolysaccharide heptosyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 345.0
TLS1_k127_2921328_11 Glycosyltransferase family 25 (LPS biosynthesis protein) - - - 0.000000000000000000000002497 113.0
TLS1_k127_2921328_12 transferase activity, transferring glycosyl groups - - - 0.000000005076 68.0
TLS1_k127_2921328_13 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.000009741 57.0
TLS1_k127_2921328_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004914 293.0
TLS1_k127_2921328_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002009 271.0
TLS1_k127_2921328_5 dipeptide transport K02035 - - 0.000000000000000000000000000000000000000000000000000000002126 218.0
TLS1_k127_2921328_6 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000001822 193.0
TLS1_k127_2921328_7 PFAM 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.0000000000000000000000000000001048 127.0
TLS1_k127_2921328_8 glycosyl transferase family 8 - - - 0.00000000000000000000000000001927 128.0
TLS1_k127_2921328_9 nuclease activity K07062 - - 0.000000000000000000000001261 108.0
TLS1_k127_2924962_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 497.0
TLS1_k127_2924962_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000005009 156.0
TLS1_k127_2924962_2 - - - - 0.00000000005126 66.0
TLS1_k127_2945115_0 pilus assembly protein K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 338.0
TLS1_k127_2945115_1 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000004757 95.0
TLS1_k127_2945115_2 Fimbrial assembly protein (PilN) K02663 - - 0.000000000001965 76.0
TLS1_k127_2949267_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 4.239e-224 711.0
TLS1_k127_2949267_1 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 424.0
TLS1_k127_2949267_2 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 348.0
TLS1_k127_2949267_3 succinate dehydrogenase K00239,K00278 - 1.3.5.1,1.3.5.4,1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 310.0
TLS1_k127_2949267_4 succinate dehydrogenase K00241 - - 0.000000000000000000000000000000000000000000000000000000000000008671 222.0
TLS1_k127_2949267_5 YCII-related domain - - - 0.00000000000000000000000000000000000005827 146.0
TLS1_k127_2949331_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 330.0
TLS1_k127_2949331_1 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0004158,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0032553,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006754 304.0
TLS1_k127_2949331_11 - - - - 0.000000713 53.0
TLS1_k127_2949331_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000002697 224.0
TLS1_k127_2949331_3 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000001585 225.0
TLS1_k127_2949331_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000001119 199.0
TLS1_k127_2949331_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.00000000000000000000000000000000000000000004372 165.0
TLS1_k127_2949331_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000003099 147.0
TLS1_k127_2949331_7 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000005986 138.0
TLS1_k127_2949331_8 Ribosomal protein L33 K02913 - - 0.0000000000000005283 78.0
TLS1_k127_2949331_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.0000000009595 64.0
TLS1_k127_2956033_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005007 394.0
TLS1_k127_2956033_1 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 356.0
TLS1_k127_2956033_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000003477 251.0
TLS1_k127_2956033_3 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000008646 208.0
TLS1_k127_2956033_4 peptidyl-prolyl cis-trans isomerase activity K03769,K03770,K03771 - 5.2.1.8 0.0000000000000000000000000000000002645 149.0
TLS1_k127_2956033_5 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.000000000000000000000000000000001051 134.0
TLS1_k127_2956033_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117,K03646 - - 0.0000000000000006931 85.0
TLS1_k127_2956033_7 Protein of unknown function (FYDLN_acid) - - - 0.0000000001926 69.0
TLS1_k127_2977931_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 477.0
TLS1_k127_2977931_1 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 464.0
TLS1_k127_2977931_2 N-acylneuraminate-9-phosphate synthase activity K01654,K15898 - 2.5.1.56,2.5.1.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 434.0
TLS1_k127_2977931_3 methyltransferase - - - 0.000000000000000000000000000000000000000004523 162.0
TLS1_k127_2977931_4 PFAM Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000003768 124.0
TLS1_k127_2977931_5 N-acetyltransferase - - - 0.00000000000000006138 93.0
TLS1_k127_2978285_0 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 613.0
TLS1_k127_2978285_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000003419 117.0
TLS1_k127_2978285_2 Acetyltransferase (GNAT) domain - - - 0.0000000000001097 76.0
TLS1_k127_297984_0 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000005266 171.0
TLS1_k127_297984_1 ECF sigma factor K03088 - - 0.000000000000000000000007886 109.0
TLS1_k127_297984_2 smart pdz dhr glgf K04691,K04771,K08070 GO:0008150,GO:0009266,GO:0009628,GO:0050896 1.3.1.74,3.4.21.107 0.00000000000000001089 91.0
TLS1_k127_2984724_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004654 264.0
TLS1_k127_2984724_1 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000002006 123.0
TLS1_k127_2984724_2 COG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000003094 126.0
TLS1_k127_2984724_3 Heavy-metal resistance - - - 0.0000001767 62.0
TLS1_k127_2991440_0 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001679 283.0
TLS1_k127_2991440_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000001483 199.0
TLS1_k127_3002476_0 sequence-specific DNA binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 445.0
TLS1_k127_3002476_1 Iron-sulfur cluster-binding domain K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 388.0
TLS1_k127_3002476_2 domain protein - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000002807 77.0
TLS1_k127_3010478_0 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 626.0
TLS1_k127_3010478_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 540.0
TLS1_k127_3010478_2 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000001385 231.0
TLS1_k127_3010478_3 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000002983 228.0
TLS1_k127_3010478_4 - - - - 0.00000000000000000000000000000000000000000001526 169.0
TLS1_k127_3010478_5 - - - - 0.000001053 54.0
TLS1_k127_3028877_0 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 352.0
TLS1_k127_3028877_1 - - - - 0.0000000000000000000000000000000000000005345 158.0
TLS1_k127_3035913_0 peptidase dimerisation domain protein K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 524.0
TLS1_k127_3035913_1 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000003108 235.0
TLS1_k127_3035913_2 - - - - 0.000000003018 70.0
TLS1_k127_305973_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 494.0
TLS1_k127_305973_1 Histidine kinase K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 302.0
TLS1_k127_305973_2 photosystem I assembly BtpA K06971 - - 0.00000000000000000000000000000000000000000000000000000000005687 215.0
TLS1_k127_3062377_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 406.0
TLS1_k127_3062377_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 368.0
TLS1_k127_3062377_2 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000852 276.0
TLS1_k127_3062377_3 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000001938 248.0
TLS1_k127_3062377_4 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000002729 158.0
TLS1_k127_3072171_0 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000001621 218.0
TLS1_k127_3072171_1 Belongs to the Nudix hydrolase family - - - 0.0000000000000000000000000000005745 126.0
TLS1_k127_3072796_0 addiction module antidote protein HigA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 547.0
TLS1_k127_3072796_1 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000002077 95.0
TLS1_k127_3073424_0 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005918 290.0
TLS1_k127_3073424_1 PFAM Mov34 MPN PAD-1 family - - - 0.0000000000000000000000002607 122.0
TLS1_k127_3073424_2 PFAM Ubiquitin-conjugating - - - 0.00000000000009921 79.0
TLS1_k127_3073424_3 WXG100 protein secretion system (Wss), protein YukD - - - 0.00000000005745 66.0
TLS1_k127_3073424_4 Putative bacterial sensory transduction regulator - - - 0.00003051 52.0
TLS1_k127_3075291_0 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000009701 254.0
TLS1_k127_3075291_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000154 216.0
TLS1_k127_3075291_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000553 175.0
TLS1_k127_3082288_0 Protein of unknown function (DUF1254) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009829 326.0
TLS1_k127_3082288_1 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 308.0
TLS1_k127_3082288_2 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000003559 153.0
TLS1_k127_3082288_3 Transposase - - - 0.0000000000000000000000004084 113.0
TLS1_k127_3082884_0 Belongs to the aldehyde dehydrogenase family K00128,K00154 - 1.2.1.3,1.2.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 488.0
TLS1_k127_3082884_3 Belongs to the aldehyde dehydrogenase family K00128,K00154 - 1.2.1.3,1.2.1.68 0.0000000000000000000000000000000000000000000008447 169.0
TLS1_k127_3082884_5 domain, Protein K19049,K20276 - 4.2.2.5 0.0004623 46.0
TLS1_k127_309463_0 Thymidylate synthase K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 451.0
TLS1_k127_309463_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006537 266.0
TLS1_k127_309463_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000351 203.0
TLS1_k127_309463_3 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287,K18589 - 1.5.1.3 0.0000000000000000000000000000000000000000000006076 171.0
TLS1_k127_3109315_0 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000003768 235.0
TLS1_k127_3109315_1 BlaR1 peptidase M56 - - - 0.0000000000000000000000000000000002183 150.0
TLS1_k127_3109315_2 Phosphoesterase family - - - 0.0000000000000000000000000000004955 132.0
TLS1_k127_3109315_3 Penicillinase repressor - - - 0.00000000000000000000000008977 111.0
TLS1_k127_3109315_4 ankyrin repeat - - - 0.0000000000000000005912 101.0
TLS1_k127_3124600_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 5.09e-250 786.0
TLS1_k127_3124600_1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 462.0
TLS1_k127_3146282_0 cyanophycin synthetase K03802 - 6.3.2.29,6.3.2.30 4.511e-246 786.0
TLS1_k127_3146282_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000007614 188.0
TLS1_k127_3149563_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 401.0
TLS1_k127_3149563_1 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 340.0
TLS1_k127_3149563_2 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009936 288.0
TLS1_k127_3149563_3 DNA recombination K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008545 257.0
TLS1_k127_3149563_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000002503 225.0
TLS1_k127_3149563_6 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000001691 128.0
TLS1_k127_3149563_7 Belongs to the 'phage' integrase family K04763 - - 0.000000000000001662 78.0
TLS1_k127_3149563_8 KTSC domain - - - 0.0000000000189 71.0
TLS1_k127_3175180_0 Involved in molybdopterin and thiamine biosynthesis, family 2 K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 329.0
TLS1_k127_3175180_1 WXG100 protein secretion system (Wss), protein YukD - - - 0.0000000002628 67.0
TLS1_k127_3216769_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 551.0
TLS1_k127_3216769_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 503.0
TLS1_k127_3216769_2 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 381.0
TLS1_k127_3216769_3 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009695 265.0
TLS1_k127_3216769_4 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.0000000000000000000000000000000000000002612 162.0
TLS1_k127_3216769_5 Forkhead associated domain K01990,K21397 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030312,GO:0031224,GO:0042623,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000008366 75.0
TLS1_k127_3225599_0 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 426.0
TLS1_k127_3225599_1 Bifunctional methylthioribulose-1-phosphate dehydratase enolase-phosphatase E1 K09880,K16054 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 3.1.3.77,4.2.1.109 0.000000000000000000000000000000000000000000000000000000000000000000000127 244.0
TLS1_k127_3225599_2 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 - 1.13.11.53,1.13.11.54 0.000000000000000000000000000000000000008316 151.0
TLS1_k127_3225599_3 Carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000007314 130.0
TLS1_k127_3243405_0 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000003693 208.0
TLS1_k127_3243405_1 Sporulation and spore germination - - - 0.00000000001643 72.0
TLS1_k127_3243550_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009473 541.0
TLS1_k127_3243550_1 Peptidase S9, prolyl oligopeptidase active site domain protein K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 503.0
TLS1_k127_3243550_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 446.0
TLS1_k127_3243550_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 349.0
TLS1_k127_3243550_4 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000002122 256.0
TLS1_k127_3243550_5 Squalene synthase HpnD K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000005998 147.0
TLS1_k127_3243550_6 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000001919 99.0
TLS1_k127_3246112_0 Peptidase family M1 domain K01992 - - 0.0 1100.0
TLS1_k127_3246112_1 ABC-type multidrug transport system ATPase component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002086 281.0
TLS1_k127_3249620_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000009621 156.0
TLS1_k127_3249620_1 Tetratricopeptide repeat - - - 0.0000004772 62.0
TLS1_k127_3250132_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 331.0
TLS1_k127_3250132_1 CheW-like domain K03408 - - 0.00000000000000000002749 96.0
TLS1_k127_3250180_0 peptidase M20 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 611.0
TLS1_k127_3250180_1 Extracellular solute-binding protein, family 5 K02035 - - 0.000000007603 59.0
TLS1_k127_3250180_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000004523 57.0
TLS1_k127_3258485_0 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 567.0
TLS1_k127_3258485_1 Belongs to the glutaminase family K01425 - 3.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 350.0
TLS1_k127_3258485_2 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000001375 267.0
TLS1_k127_3258485_3 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001283 261.0
TLS1_k127_3259535_0 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 532.0
TLS1_k127_3259535_1 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 409.0
TLS1_k127_3259535_2 PA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 370.0
TLS1_k127_3259535_3 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000002612 162.0
TLS1_k127_3261681_0 PFAM phosphoesterase K01114 - 3.1.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 396.0
TLS1_k127_3261681_1 transcription factor binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 421.0
TLS1_k127_3261681_2 Phage derived protein Gp49-like (DUF891) - - - 0.00000000000004069 74.0
TLS1_k127_3261681_3 retrograde transport, endosome to plasma membrane K21440 - - 0.0000000000007256 72.0
TLS1_k127_3261681_4 Helix-turn-helix domain - - - 0.0006591 45.0
TLS1_k127_3268315_0 iron assimilation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 369.0
TLS1_k127_3268315_1 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007167 273.0
TLS1_k127_3268315_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001044 258.0
TLS1_k127_3268315_3 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000002473 233.0
TLS1_k127_3268315_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000002462 156.0
TLS1_k127_3268315_5 Cell wall-active antibiotics response 4TMS YvqF - - - 0.000000000000000000000000000000006046 139.0
TLS1_k127_3268315_6 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.00000000000000000000000004217 119.0
TLS1_k127_3268315_7 Tetratricopeptide repeat - - - 0.00000000000001055 89.0
TLS1_k127_3268315_8 - - - - 0.0000000006081 67.0
TLS1_k127_329970_0 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001458 282.0
TLS1_k127_329970_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000002903 253.0
TLS1_k127_329970_2 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000153 178.0
TLS1_k127_329970_3 unfolded protein binding K06142 - - 0.0000000000007519 73.0
TLS1_k127_3319499_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 476.0
TLS1_k127_3319499_1 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 356.0
TLS1_k127_3319499_10 Protein of unknown function (DUF2442) - - - 0.00000000007568 68.0
TLS1_k127_3319499_11 Type II secretion system protein G K02456 - - 0.0000002229 63.0
TLS1_k127_3319499_12 integral membrane protein K02221 - - 0.00003493 50.0
TLS1_k127_3319499_13 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.00008336 54.0
TLS1_k127_3319499_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000002385 205.0
TLS1_k127_3319499_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000162 202.0
TLS1_k127_3319499_4 Reverse transcriptase-like K03469 - 3.1.26.4 0.0000000000000000000000000000000000000495 149.0
TLS1_k127_3319499_5 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000001172 148.0
TLS1_k127_3319499_6 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000004808 132.0
TLS1_k127_3319499_7 positive regulation of growth rate - - - 0.00000000000000000000000004249 122.0
TLS1_k127_3319499_8 Protein of unknown function (DUF2442) - - - 0.000000000000000000000002166 104.0
TLS1_k127_3319499_9 PFAM DivIVA protein K04074 - - 0.00000000000008681 78.0
TLS1_k127_3336995_0 Splits dipeptides with a prolyl residue in the C- terminal position K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 466.0
TLS1_k127_3336995_1 Protein of unknown function (DUF2721) - - - 0.000000000003075 78.0
TLS1_k127_3336995_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000001594 68.0
TLS1_k127_3341628_0 Protein export membrane protein K07003 - - 0.000000000000000000000000000000000000000000000000000000000000602 238.0
TLS1_k127_3341746_0 Domain of unknown function (DUF1835) - - - 0.000000000000000000000000000000000001745 151.0
TLS1_k127_3341746_1 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.00000145 60.0
TLS1_k127_3354376_0 TIGRFAM RHS repeat-associated core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005163 593.0
TLS1_k127_3354376_1 C-terminal domain of CHU protein family K20276 - - 0.00000000000000000000000000000000000000000000000000000000000006335 245.0
TLS1_k127_3362732_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003979 454.0
TLS1_k127_3362732_1 SIR2-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006493 287.0
TLS1_k127_3362732_2 WD40 repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002636 294.0
TLS1_k127_3362732_3 Biogenesis protein - - - 0.0005154 49.0
TLS1_k127_3376987_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003734 463.0
TLS1_k127_3376987_1 PFAM Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000008602 259.0
TLS1_k127_3389053_0 transferase activity, transferring acyl groups K14658,K17840,K18815 - 2.3.1.59,2.3.1.82 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008362 400.0
TLS1_k127_3390958_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000741 367.0
TLS1_k127_3390958_1 histidine kinase, dimerisation and phosphoacceptor region K02480 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009829 277.0
TLS1_k127_3390958_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000003715 193.0
TLS1_k127_3390958_3 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000000003296 171.0
TLS1_k127_3390958_4 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000127 166.0
TLS1_k127_3390958_5 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.0000000000000000000000000000000172 129.0
TLS1_k127_3390958_6 Phosphoglycerate mutase family - - - 0.00000000000000000000269 98.0
TLS1_k127_3390958_7 WD40-like Beta Propeller Repeat - - - 0.0000000000009367 76.0
TLS1_k127_3409336_0 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002005 278.0
TLS1_k127_3409336_1 ABC transporter, phosphonate, periplasmic substrate-binding protein K02020 - - 0.0000000000000000000000000000000000000000000000000000000000005597 218.0
TLS1_k127_3409336_2 - - - - 0.000000000000000000000000000000000000000000000000007762 190.0
TLS1_k127_3409336_3 - - - - 0.000000000000000227 81.0
TLS1_k127_3409336_4 manually curated - - - 0.0000000000000006129 80.0
TLS1_k127_3409336_5 - - - - 0.0000000000003798 70.0
TLS1_k127_3409336_7 Psort location Cytoplasmic, score 8.87 K07339 - - 0.0000000002502 65.0
TLS1_k127_3409336_8 - - - - 0.000004589 56.0
TLS1_k127_3409336_9 - - - - 0.00005664 47.0
TLS1_k127_341177_0 Ribosomal protein S1 K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 604.0
TLS1_k127_341177_1 alpha-L-arabinofuranosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 550.0
TLS1_k127_341177_10 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000523 174.0
TLS1_k127_341177_11 tigr00255 - - - 0.000000000000000000000000000000000000000000008512 173.0
TLS1_k127_341177_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000001883 159.0
TLS1_k127_341177_13 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000127 150.0
TLS1_k127_341177_14 domain, Protein - - - 0.00000000000000000000000000000000000001425 168.0
TLS1_k127_341177_15 protein conserved in bacteria K09778 - - 0.00000000000000000000000000000000001426 143.0
TLS1_k127_341177_16 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.000000000000000000000000000000001302 133.0
TLS1_k127_341177_17 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000008374 82.0
TLS1_k127_341177_18 - - - - 0.0000000000000002453 83.0
TLS1_k127_341177_19 Toxic component of a toxin-antitoxin (TA) module. An RNase K18828 - - 0.0000000000003432 75.0
TLS1_k127_341177_2 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 494.0
TLS1_k127_341177_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 419.0
TLS1_k127_341177_4 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008097 375.0
TLS1_k127_341177_5 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003233 287.0
TLS1_k127_341177_6 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000004297 244.0
TLS1_k127_341177_7 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000007469 238.0
TLS1_k127_341177_8 Cytidylate kinase K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000001624 189.0
TLS1_k127_341177_9 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000128 184.0
TLS1_k127_3423533_0 SNF2 family N-terminal domain - - - 0.000000000000000000000000000000001139 148.0
TLS1_k127_3423533_1 - - - - 0.0000000000000000000000006354 110.0
TLS1_k127_3423533_2 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000000004112 102.0
TLS1_k127_3423533_3 - - - - 0.00000000000000001384 87.0
TLS1_k127_3423533_4 type II restriction enzyme - - - 0.0000002256 63.0
TLS1_k127_3444447_0 3-oxoacyl-[acyl-carrier-protein] synthase activity K09458,K18473 - 2.3.1.179,2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004805 582.0
TLS1_k127_3444447_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 333.0
TLS1_k127_3444447_2 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003145 259.0
TLS1_k127_3444447_3 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000006172 252.0
TLS1_k127_3444447_4 Protein of unknown function (DUF1579) - - - 0.0000000000000000000000000000000000001541 148.0
TLS1_k127_3444447_5 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000002623 161.0
TLS1_k127_3444447_6 COG1278 Cold shock proteins K03704 - - 0.0000000000000000000000005766 105.0
TLS1_k127_3447117_0 O-acetylhomoserine K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000001369 171.0
TLS1_k127_3447137_0 - K07071 - - 0.000000000000000000000000000000000000000001837 164.0
TLS1_k127_3452755_0 electron transfer flavoprotein, alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004781 286.0
TLS1_k127_3452755_1 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000002059 255.0
TLS1_k127_3452755_2 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000002502 229.0
TLS1_k127_3452755_3 Hfq protein - - - 0.00000000000000000000000000692 114.0
TLS1_k127_3455157_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 444.0
TLS1_k127_3455157_1 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 408.0
TLS1_k127_3455157_10 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000001238 113.0
TLS1_k127_3455157_11 - - - - 0.0000000000000000000000002516 106.0
TLS1_k127_3455157_12 - - - - 0.000000000004832 71.0
TLS1_k127_3455157_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 374.0
TLS1_k127_3455157_3 Phosphate transport system permease K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008915 346.0
TLS1_k127_3455157_4 Protein of unknown function (DUF1385) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 313.0
TLS1_k127_3455157_5 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000004367 243.0
TLS1_k127_3455157_6 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000000000000000494 203.0
TLS1_k127_3455157_7 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000002158 200.0
TLS1_k127_3455157_8 PFAM response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000000000000000000000000000000000001342 198.0
TLS1_k127_3455157_9 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000002094 167.0
TLS1_k127_3472153_0 amino acid activation for nonribosomal peptide biosynthetic process K03641,K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 372.0
TLS1_k127_3472153_1 - - - - 0.0000000000000000000000007601 109.0
TLS1_k127_3484774_0 protein histidine kinase activity - - - 1.41e-317 993.0
TLS1_k127_3484774_1 PFAM Glycosyl transferase, group 1 - - - 2.058e-277 877.0
TLS1_k127_3484774_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 475.0
TLS1_k127_3484774_3 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000007902 188.0
TLS1_k127_3484774_4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000007326 90.0
TLS1_k127_3484774_5 GGDEF domain - - - 0.000000000000000004034 91.0
TLS1_k127_3501306_0 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 440.0
TLS1_k127_3501306_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003631 275.0
TLS1_k127_3501306_2 cell shape determining protein MreB K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001207 244.0
TLS1_k127_3501306_3 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000002716 149.0
TLS1_k127_3501306_4 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000004508 140.0
TLS1_k127_3501306_5 bacterial (prokaryotic) histone like domain K03530 - - 0.000000000000000000000000003245 114.0
TLS1_k127_3501306_6 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit S4 paralog K04762 - - 0.00000000000000000000000001901 113.0
TLS1_k127_3502419_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 589.0
TLS1_k127_3502419_1 ATP-dependent DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 426.0
TLS1_k127_3512811_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 512.0
TLS1_k127_3512811_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 319.0
TLS1_k127_3512811_10 TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - 0.0007738 51.0
TLS1_k127_3512811_2 peptidase U61 LD-carboxypeptidase A K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 317.0
TLS1_k127_3512811_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000001062 214.0
TLS1_k127_3512811_4 Metallo-beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000733 195.0
TLS1_k127_3512811_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000168 93.0
TLS1_k127_3512811_6 PFAM Uncharacterised protein family (UPF0150) - - - 0.000000000000000006742 84.0
TLS1_k127_3512811_7 - - - - 0.0000000006082 72.0
TLS1_k127_3512811_8 CsbD-like - - - 0.000000004458 61.0
TLS1_k127_3512811_9 HEPN domain - - - 0.00000007399 59.0
TLS1_k127_3519647_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 466.0
TLS1_k127_3519647_1 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 474.0
TLS1_k127_3519647_2 Polysaccharide lyase family 4, domain II - - - 0.000000000000000000000000000000000000000000000000004391 186.0
TLS1_k127_3532338_0 Peptidase family M20/M25/M40 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008295 270.0
TLS1_k127_353557_0 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000000000000000007459 229.0
TLS1_k127_353557_1 Organic Anion Transporter Polypeptide (OATP) family - - - 0.000000000000000000000000000000000000000000000000000000000003722 213.0
TLS1_k127_35367_0 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 373.0
TLS1_k127_35367_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 306.0
TLS1_k127_35367_2 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000001543 215.0
TLS1_k127_353776_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 5.13e-262 827.0
TLS1_k127_353776_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000000000000000000000000000000000000000000000000000000000000334 218.0
TLS1_k127_3543112_0 Fructose-bisphosphate aldolase class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 470.0
TLS1_k127_3543112_1 phosphinothricin N-acetyltransferase activity - - - 0.000000000000000000000000004403 116.0
TLS1_k127_3569014_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 9.077e-256 799.0
TLS1_k127_3569014_1 TIGRFAM MazG family protein K02428,K02499,K04765 - 3.6.1.66,3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001522 268.0
TLS1_k127_3569014_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001731 255.0
TLS1_k127_3569014_3 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000001028 224.0
TLS1_k127_3569014_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000007038 72.0
TLS1_k127_3577661_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009971 277.0
TLS1_k127_3577661_1 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000006849 244.0
TLS1_k127_3577661_2 - K16052 - - 0.00000000000000000000000000000000000004365 150.0
TLS1_k127_3577661_3 Protein of unknown function (DUF420) K08976 - - 0.000000000000000000000000000000000001161 143.0
TLS1_k127_3577661_4 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000002157 139.0
TLS1_k127_3577661_5 SCO1/SenC K07152 - - 0.0000000000000000000000000000000009026 137.0
TLS1_k127_3577661_6 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000000000000000000003862 135.0
TLS1_k127_3577661_7 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form - - - 0.0000000000000000000000000000003814 137.0
TLS1_k127_3577661_8 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000871 128.0
TLS1_k127_3577661_9 Fic/DOC family - - - 0.0000000000000000000003764 107.0
TLS1_k127_3582606_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 424.0
TLS1_k127_3582606_1 Catalyzes the reversible hydration of fumarate to (S)- malate K01676,K03780 - 4.2.1.2,4.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000003216 248.0
TLS1_k127_3605080_0 Surface antigen variable number K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 342.0
TLS1_k127_3605080_1 Calcineurin-like phosphoesterase K14379 - 3.1.3.2 0.0000000000000000000000000001009 127.0
TLS1_k127_3614652_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1013.0
TLS1_k127_3614652_1 helix_turn_helix gluconate operon transcriptional repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 476.0
TLS1_k127_3614652_2 spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000899 304.0
TLS1_k127_3614652_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000001416 216.0
TLS1_k127_3614652_4 Protein of unknown function (DUF4065) - - - 0.0000000000000000000000000000000000000000000000000000003852 198.0
TLS1_k127_3614652_5 - - - - 0.000000000000003133 81.0
TLS1_k127_3614652_6 von Willebrand factor type A domain K07114 - - 0.00001253 57.0
TLS1_k127_362273_0 Helix-turn-helix - - - 0.00000000000000004045 84.0
TLS1_k127_362273_1 IrrE N-terminal-like domain - - - 0.0000000000000006187 89.0
TLS1_k127_362520_0 Peptidase, M61 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 321.0
TLS1_k127_362520_1 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000007338 207.0
TLS1_k127_362520_2 Methyltransferase domain - - - 0.000000008815 66.0
TLS1_k127_362520_3 - - - - 0.00000004651 57.0
TLS1_k127_3647742_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.0000000000000000000000000000000000000002259 154.0
TLS1_k127_3647742_1 Diguanylate cyclase - - - 0.000000000000000000000000000365 130.0
TLS1_k127_3650711_0 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000004334 231.0
TLS1_k127_3650711_1 SMART phosphoesterase PHP domain protein K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000003694 197.0
TLS1_k127_3667987_0 Inner membrane component of T3SS, cytoplasmic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001252 287.0
TLS1_k127_3667987_1 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003026 272.0
TLS1_k127_3667987_2 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000002538 233.0
TLS1_k127_3667987_3 Putative stress-induced transcription regulator - - - 0.0000000000000000000000000001558 122.0
TLS1_k127_3667987_4 outer membrane autotransporter barrel domain protein - - - 0.00000000000000001862 89.0
TLS1_k127_3679034_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008246 285.0
TLS1_k127_3679034_1 PFAM Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000002654 211.0
TLS1_k127_3692406_0 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000009755 235.0
TLS1_k127_3692406_1 Glycosyltransferase like family 2 K20444 - - 0.0000000000000000000000000000000000000000000000000000000001402 227.0
TLS1_k127_3692406_2 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000000000000000001208 208.0
TLS1_k127_3692406_3 Bacterial lipid A biosynthesis acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000202 202.0
TLS1_k127_3692406_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000521 175.0
TLS1_k127_3692406_5 Methyltransferase domain - - - 0.00000000000000009103 85.0
TLS1_k127_3692679_0 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005098 375.0
TLS1_k127_3692679_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000133 258.0
TLS1_k127_3692679_2 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000166 202.0
TLS1_k127_3692679_3 4Fe-4S single cluster domain - - - 0.0000004241 55.0
TLS1_k127_3699660_0 Leukotriene A4 hydrolase, C-terminal - - - 2.61e-228 721.0
TLS1_k127_3699660_1 OPT oligopeptide transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 540.0
TLS1_k127_3699660_2 - - - - 0.00000000000000000000000001591 116.0
TLS1_k127_3699660_3 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000001185 83.0
TLS1_k127_3707577_0 N-6 DNA Methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 612.0
TLS1_k127_3707577_1 XamI restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005428 300.0
TLS1_k127_3707577_2 PFAM Phytanoyl-CoA dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000247 284.0
TLS1_k127_371077_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007486 296.0
TLS1_k127_371077_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000201 131.0
TLS1_k127_3717354_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000003631 192.0
TLS1_k127_3728869_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007785 291.0
TLS1_k127_3728869_1 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008054 258.0
TLS1_k127_3730344_0 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000001353 196.0
TLS1_k127_3730344_1 ECF sigma factor K03088 - - 0.00000007265 61.0
TLS1_k127_3730344_2 sequence-specific DNA binding - - - 0.000002543 60.0
TLS1_k127_3746768_0 DoxX K15977 - - 0.0000000003326 62.0
TLS1_k127_3746768_1 phosphorelay signal transduction system - - - 0.00001646 57.0
TLS1_k127_3748372_0 COG0642 Signal transduction histidine kinase K14980 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000001428 238.0
TLS1_k127_3748372_1 COG1233 Phytoene dehydrogenase and related - - - 0.0000000000000000000000000000000004661 132.0
TLS1_k127_3748449_0 tRNA synthetases class I (W and Y) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.000000000000000000000000000000000000000000000000000313 190.0
TLS1_k127_3750388_0 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000002921 267.0
TLS1_k127_3750388_1 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000002336 185.0
TLS1_k127_3759577_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 2.03e-304 949.0
TLS1_k127_3762355_0 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000001157 246.0
TLS1_k127_3762355_1 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000002839 245.0
TLS1_k127_3762355_2 fatty acid desaturase transmembrane protein - - - 0.000000000000000009644 94.0
TLS1_k127_3764466_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 477.0
TLS1_k127_3764466_1 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 441.0
TLS1_k127_3764466_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 389.0
TLS1_k127_3764466_3 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000438 267.0
TLS1_k127_3764466_4 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002153 274.0
TLS1_k127_3764466_5 Glycine cleavage H-protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001948 231.0
TLS1_k127_3764466_6 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000005932 221.0
TLS1_k127_3764466_7 Peptidase family M54 K06974 - - 0.000000000000000000000000000000000000000000000000000004167 195.0
TLS1_k127_3764466_8 Tautomerase enzyme - - - 0.00000000000000000003194 96.0
TLS1_k127_3781016_0 heat shock protein binding K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 319.0
TLS1_k127_3781016_1 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 317.0
TLS1_k127_3781016_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000002601 171.0
TLS1_k127_3781198_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1088.0
TLS1_k127_3781198_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 612.0
TLS1_k127_3781198_2 Glutamine amidotransferase domain K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 523.0
TLS1_k127_3781198_3 hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 375.0
TLS1_k127_3781329_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.273e-226 712.0
TLS1_k127_3781329_1 PFAM Peptidase M1, membrane alanine aminopeptidase K01256,K08776 - 3.4.11.2 4.876e-219 708.0
TLS1_k127_3781329_2 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 467.0
TLS1_k127_3781329_3 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 399.0
TLS1_k127_3781329_4 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 299.0
TLS1_k127_3781329_5 PFAM NAD binding domain of 6-phosphogluconate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000001103 263.0
TLS1_k127_3781329_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000001376 178.0
TLS1_k127_3781329_7 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000006838 140.0
TLS1_k127_3785092_0 Dynamin family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 429.0
TLS1_k127_3785092_1 - - - - 0.000000000006502 72.0
TLS1_k127_3796519_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.686e-218 692.0
TLS1_k127_3796519_1 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000001628 200.0
TLS1_k127_3800788_0 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 517.0
TLS1_k127_3800788_1 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 335.0
TLS1_k127_3802989_0 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 1.684e-196 623.0
TLS1_k127_3802989_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 331.0
TLS1_k127_3809768_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 3.171e-208 655.0
TLS1_k127_3821782_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 344.0
TLS1_k127_3821782_1 - - - - 0.00000000000000000000000000000000000000000000000000001659 194.0
TLS1_k127_3821782_2 - - - - 0.0000000000000000000000000000148 123.0
TLS1_k127_3835356_0 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000002073 237.0
TLS1_k127_3835356_1 Dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000002071 213.0
TLS1_k127_3835356_2 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000129 141.0
TLS1_k127_3835356_3 phosphoesterase, PA-phosphatase related - - - 0.0000000000000000004265 94.0
TLS1_k127_3843189_0 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000003495 222.0
TLS1_k127_3843189_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000003924 89.0
TLS1_k127_3843189_2 Protein of unknown function (DUF503) K09764 - - 0.000000002205 62.0
TLS1_k127_3847787_0 Tetratricopeptide repeat - - - 8.768e-254 795.0
TLS1_k127_3847787_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.118e-236 760.0
TLS1_k127_3847787_2 Belongs to the beta-ketoacyl-ACP synthases family K14660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 362.0
TLS1_k127_3847787_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002281 281.0
TLS1_k127_3847787_4 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000003026 162.0
TLS1_k127_3847787_5 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000001002 76.0
TLS1_k127_3847787_6 Phosphopantetheine attachment site - - - 0.00009597 53.0
TLS1_k127_3898932_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 454.0
TLS1_k127_3898932_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 451.0
TLS1_k127_3898932_2 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 394.0
TLS1_k127_3898932_3 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001856 269.0
TLS1_k127_3898932_4 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000002586 241.0
TLS1_k127_3898932_5 GHMP kinase K00869,K07031 - 2.7.1.168,2.7.1.36 0.0000000000000000000000000000000000000000000000000000000001809 227.0
TLS1_k127_3898932_6 Preprotein translocase, YajC K03210 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000001287 91.0
TLS1_k127_3898932_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - 0.00005417 53.0
TLS1_k127_3905280_0 Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000006241 233.0
TLS1_k127_3905655_0 YmdB-like protein K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 301.0
TLS1_k127_3905655_1 RNA pseudouridylate synthase K06177,K06180 - 5.4.99.23,5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000994 237.0
TLS1_k127_3905655_2 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000002797 79.0
TLS1_k127_3905655_3 PA domain - - - 0.0000000001254 65.0
TLS1_k127_3906749_0 receptor K16091 - - 3.645e-195 631.0
TLS1_k127_3906749_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 381.0
TLS1_k127_3906749_2 YCII-related domain - - - 0.000000000000000000000000000000000000000000000000003344 187.0
TLS1_k127_3908767_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005661 477.0
TLS1_k127_3908767_1 Tim44 K15539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003808 289.0
TLS1_k127_3908767_2 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000000000000000000000007011 176.0
TLS1_k127_3913932_0 PFAM peptidase M14, carboxypeptidase A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 404.0
TLS1_k127_3913932_1 copper resistance - - - 0.000000000000000000000000006336 123.0
TLS1_k127_3915966_1 - - - - 0.0000000001614 70.0
TLS1_k127_3916649_0 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000006093 205.0
TLS1_k127_3916649_1 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000003807 107.0
TLS1_k127_3916649_2 - - - - 0.00000000000006544 74.0
TLS1_k127_3916649_3 Phage Tail Collar Domain - - - 0.0000007406 56.0
TLS1_k127_3916649_4 Putative addiction module component - - - 0.00001145 50.0
TLS1_k127_3924314_0 - - - - 3.952e-263 829.0
TLS1_k127_3924314_1 Pirin C-terminal cupin domain K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 323.0
TLS1_k127_3924314_2 PFAM EAL domain - - - 0.00000000000000000000000000000000000000000000000000004361 208.0
TLS1_k127_3926934_0 PFAM Transketolase central region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003446 424.0
TLS1_k127_3926934_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000001249 227.0
TLS1_k127_3938746_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 378.0
TLS1_k127_3938746_1 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000005155 110.0
TLS1_k127_393989_0 PFAM Haloacid dehalogenase domain protein hydrolase K01560,K07025 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000003598 263.0
TLS1_k127_3945583_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 527.0
TLS1_k127_3945583_1 - - - - 0.00000000000008457 73.0
TLS1_k127_3947322_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 311.0
TLS1_k127_3947322_1 Sodium:dicarboxylate symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000004205 233.0
TLS1_k127_3947322_2 - - - - 0.0000000000000000000000000000000000000001987 167.0
TLS1_k127_3947322_3 Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000001296 154.0
TLS1_k127_3955011_0 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000839 194.0
TLS1_k127_3955011_1 Tryptophan 2,3-dioxygenase - - - 0.000000000000000000000000000000000000000000008659 171.0
TLS1_k127_3955011_2 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.00000000000000000000000001001 114.0
TLS1_k127_3955011_3 TIGRFAM TonB K03832 - - 0.0000000000000000000000003317 115.0
TLS1_k127_3955011_4 biopolymer transport protein K03559,K03560 - - 0.00000000000000000001704 96.0
TLS1_k127_3955011_5 Peptidase M56 - - - 0.0000000000000000001298 103.0
TLS1_k127_3955011_6 Tetratricopeptide repeat - - - 0.0000000000006528 79.0
TLS1_k127_3955011_7 methylamine metabolic process K15977 - - 0.000000001202 65.0
TLS1_k127_3979883_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004523 346.0
TLS1_k127_3979883_1 DNA methylase K00571 - 2.1.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006761 294.0
TLS1_k127_3979883_2 Phage integrase family - - - 0.000000000000000000000000000000000000000000000000001857 200.0
TLS1_k127_3979883_3 - - - - 0.0000000000000000000000000000000000000004078 156.0
TLS1_k127_3979883_4 protein secretion K21449 - - 0.00001907 57.0
TLS1_k127_3993161_0 Asparaginase K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 396.0
TLS1_k127_3993161_1 YjbR - - - 0.00000000000000000000000000000000000001318 147.0
TLS1_k127_4021190_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 565.0
TLS1_k127_4021190_1 Possibly the antitoxin component of a type II toxin- antitoxin (TA) system - - - 0.0000009963 51.0
TLS1_k127_402904_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 436.0
TLS1_k127_402904_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000002513 239.0
TLS1_k127_402904_2 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000007682 159.0
TLS1_k127_402904_3 transcription factor binding K13599 - - 0.0000000000009065 82.0
TLS1_k127_402904_4 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000009055 70.0
TLS1_k127_402904_5 Hpt domain - - - 0.0000004655 57.0
TLS1_k127_4034590_0 CHAD - - - 0.00000000000000000000000000000000000000000002529 173.0
TLS1_k127_4034590_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000001913 136.0
TLS1_k127_4034590_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564 2.7.4.1 0.00000000000000000000000000000008615 130.0
TLS1_k127_4041032_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K03918 - 2.6.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 524.0
TLS1_k127_4041032_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007771 448.0
TLS1_k127_4070223_0 Xanthine dehydrogenase K13482 - 1.17.1.4 3.772e-241 765.0
TLS1_k127_4070223_1 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002315 246.0
TLS1_k127_4070223_2 Belongs to the HpcH HpaI aldolase family - - - 0.00000000000000009603 82.0
TLS1_k127_4072079_0 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 550.0
TLS1_k127_4072079_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000006237 127.0
TLS1_k127_4072079_2 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000003003 111.0
TLS1_k127_4072079_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000001124 105.0
TLS1_k127_4072079_4 - - - - 0.00000000000000001958 88.0
TLS1_k127_4072079_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be K00337 - 1.6.5.3 0.0000000000006156 70.0
TLS1_k127_4072117_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 491.0
TLS1_k127_4072117_1 Biotin carboxylase C-terminal domain K01965,K01968 - 6.4.1.3,6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000009799 253.0
TLS1_k127_4072117_2 Enoyl-CoA hydratase/isomerase K13766,K13779 - 4.2.1.18,4.2.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000002964 251.0
TLS1_k127_4072117_3 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000001162 234.0
TLS1_k127_4072117_4 domain, Protein K20276 - - 0.0000000000000000000000000000000000000000000000001999 201.0
TLS1_k127_4088209_0 cellulose binding - - - 0.0 1245.0
TLS1_k127_4088209_1 hydrolase activity - - - 0.000000000000000000000000000000000000000000000000004379 188.0
TLS1_k127_4088209_2 Beta-lactamase - - - 0.000000000000000000002739 107.0
TLS1_k127_4090121_0 Transposase IS200 like - - - 0.000000000000000000000000000000000000000000000000000000000000008252 233.0
TLS1_k127_4090121_1 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000000000000000000001159 118.0
TLS1_k127_4090121_2 protein secretion by the type I secretion system K11085 - - 0.00000000000000000000000008273 115.0
TLS1_k127_4090121_3 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000004721 101.0
TLS1_k127_409482_0 Alpha-amylase domain K05343 - 3.2.1.1,5.4.99.16 0.0 1261.0
TLS1_k127_409482_1 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001226 275.0
TLS1_k127_409482_2 COGs COG0674 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase alpha subunit K00174 - 1.2.7.11,1.2.7.3 0.000000578 54.0
TLS1_k127_4098500_0 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 424.0
TLS1_k127_4098500_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 348.0
TLS1_k127_4098500_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000002257 230.0
TLS1_k127_4098500_3 - - - - 0.0000000000000000000000000000000008421 142.0
TLS1_k127_4098500_4 PFAM cytochrome c assembly protein - - - 0.00000000000000000000000000008483 126.0
TLS1_k127_4098500_5 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000007394 106.0
TLS1_k127_4098500_6 aminopeptidase - - - 0.0000000000000000004781 96.0
TLS1_k127_4099448_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004154 304.0
TLS1_k127_4099448_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 0.0000000000000000000000000000000000000001972 164.0
TLS1_k127_4099448_2 Peptidase family M20/M25/M40 - - - 0.0000000000000000000000000001363 132.0
TLS1_k127_4103160_0 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 450.0
TLS1_k127_4103160_1 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000000000000000001087 104.0
TLS1_k127_4103160_2 HicA toxin of bacterial toxin-antitoxin, K07339 - - 0.00000000002195 65.0
TLS1_k127_4103160_3 Glycosyltransferase like family 2 - - - 0.000000003269 70.0
TLS1_k127_4104309_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1030.0
TLS1_k127_4104309_1 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 505.0
TLS1_k127_4104309_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 399.0
TLS1_k127_4104309_3 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 295.0
TLS1_k127_4104309_4 PA14 domain - - - 0.000000001614 72.0
TLS1_k127_4104309_5 Protein of unknown function (DUF3344) - - - 0.0000004031 64.0
TLS1_k127_4115649_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008975 489.0
TLS1_k127_4115649_1 Conserved hypothetical protein (DUF2461) - - - 0.0000000000000000000000000000000000000000000003213 175.0
TLS1_k127_4115649_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000007125 91.0
TLS1_k127_4119786_0 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 437.0
TLS1_k127_4119786_1 Cation efflux family K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005006 250.0
TLS1_k127_4119786_2 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000001274 229.0
TLS1_k127_4119786_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000002288 167.0
TLS1_k127_4119819_0 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005306 270.0
TLS1_k127_4119819_1 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.000000000000000000000000000003252 133.0
TLS1_k127_4119819_2 PFAM Metal-dependent phosphohydrolase, HD K00970 - 2.7.7.19 0.000003687 59.0
TLS1_k127_4121201_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000896 519.0
TLS1_k127_4121201_1 PFAM NAD-dependent epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 492.0
TLS1_k127_4121201_2 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 312.0
TLS1_k127_4121201_3 protein methyltransferase activity - - - 0.0000000000000000000000000000000001384 144.0
TLS1_k127_4121201_4 MarR family - - - 0.0000000000002612 71.0
TLS1_k127_4127544_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 506.0
TLS1_k127_4127605_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 427.0
TLS1_k127_4127605_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004165 287.0
TLS1_k127_4127605_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005041 272.0
TLS1_k127_4127605_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000184 116.0
TLS1_k127_4127605_4 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000009057 67.0
TLS1_k127_4127605_5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000003129 70.0
TLS1_k127_4127882_0 BlaR1 peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009559 376.0
TLS1_k127_4127882_1 Penicillinase repressor - - - 0.00000000000000000000000000000000000000000001271 168.0
TLS1_k127_4127882_2 - - - - 0.0000000000000000000000000000004402 124.0
TLS1_k127_4127882_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000000000000000007713 121.0
TLS1_k127_4133086_0 - - - - 0.0000000000000000000000000004312 125.0
TLS1_k127_4133086_1 TIR domain - - - 0.000000000000000000000001232 115.0
TLS1_k127_4133086_2 Ribonuclease - - - 0.0000000000000000001315 94.0
TLS1_k127_4133086_3 Alpha/beta hydrolase family - - - 0.00000000000000005958 85.0
TLS1_k127_4133086_4 Alpha/beta hydrolase family - - - 0.000000000001305 70.0
TLS1_k127_4133086_6 Barstar (barnase inhibitor) - - - 0.00000006601 63.0
TLS1_k127_4150016_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 4.088e-222 704.0
TLS1_k127_4150016_1 L-lysine 6-monooxygenase (NADPH-requiring) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 519.0
TLS1_k127_4150016_2 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 457.0
TLS1_k127_4150016_3 Major facilitator Superfamily - - - 0.00000000000000000000000000001421 125.0
TLS1_k127_4150016_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000008259 104.0
TLS1_k127_4154347_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 341.0
TLS1_k127_4154347_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000007351 257.0
TLS1_k127_4180006_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 389.0
TLS1_k127_4180006_1 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000001219 204.0
TLS1_k127_4203372_0 Peptidase family M3 K01392 - 3.4.24.15 3.457e-210 671.0
TLS1_k127_4203372_1 PFAM RNA binding S1 domain protein K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 295.0
TLS1_k127_4203372_2 - - - - 0.000000000000000000000000000000000000000000000001823 187.0
TLS1_k127_4203372_3 ApaG domain K06195 - - 0.00000000000000000000000000000000000000004475 154.0
TLS1_k127_4203372_4 Domain of unknown function (DUF4403) - - - 0.00000000000000000000000000000000000004267 160.0
TLS1_k127_4203372_5 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000001521 138.0
TLS1_k127_4203372_6 Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000000001367 118.0
TLS1_k127_4203372_7 transcriptional regulator K07729 - - 0.0000000000000000000002766 104.0
TLS1_k127_4203372_8 - - - - 0.0000000008817 66.0
TLS1_k127_4203372_9 Zinc metalloprotease (Elastase) K01183 - 3.2.1.14 0.0002024 54.0
TLS1_k127_4203931_0 PFAM SMP-30 Gluconolaconase K20952 - - 0.00000000000000000000179 109.0
TLS1_k127_4210586_0 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 439.0
TLS1_k127_4210586_1 RelA SpoT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000009672 229.0
TLS1_k127_4210586_2 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000009948 120.0
TLS1_k127_4210586_3 membrane protein (homolog of Drosophila rhomboid) - - - 0.0000000008486 70.0
TLS1_k127_4210809_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.000394 49.0
TLS1_k127_4239979_0 DNA polymerase III subunits gamma and tau domain III K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 343.0
TLS1_k127_4239979_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000001389 175.0
TLS1_k127_4239979_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000001978 67.0
TLS1_k127_4239979_3 Recombinase zinc beta ribbon domain - - - 0.000000004354 64.0
TLS1_k127_4244151_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 330.0
TLS1_k127_4244151_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000002159 255.0
TLS1_k127_4272216_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 2.58e-231 735.0
TLS1_k127_4272216_1 C-5 cytosine-specific DNA methylase K00558 - 2.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008883 514.0
TLS1_k127_4272216_10 Transcriptional regulator, AbiEi antitoxin - - - 0.0000000000000003492 83.0
TLS1_k127_4272216_11 iron dependent repressor - - - 0.00000000000001554 81.0
TLS1_k127_4272216_12 PFAM sigma-70 region 2 domain protein K03088 - - 0.00000002566 65.0
TLS1_k127_4272216_13 CHAT domain - - - 0.0000002173 65.0
TLS1_k127_4272216_14 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000002647 61.0
TLS1_k127_4272216_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006588 406.0
TLS1_k127_4272216_3 B-1 B cell differentiation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008175 327.0
TLS1_k127_4272216_4 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000004426 209.0
TLS1_k127_4272216_5 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000001653 143.0
TLS1_k127_4272216_6 CHAT domain - - - 0.00000000000000000000000000000001445 148.0
TLS1_k127_4272216_7 T/G mismatch-specific endonuclease activity K07458 - - 0.0000000000000000000000000000000195 131.0
TLS1_k127_4272216_8 - - - - 0.0000000000000000000000000004629 117.0
TLS1_k127_4272216_9 Protein of unknown function (DUF433) - - - 0.00000000000000000000001303 102.0
TLS1_k127_4274754_0 GTP binding K06883 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007039 265.0
TLS1_k127_4274754_1 Lytic transglycosylase catalytic K08307 - - 0.000000000000000000000000000000000000000000000000000000000004717 221.0
TLS1_k127_4280598_0 Belongs to the HypD family K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 488.0
TLS1_k127_4280598_1 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 440.0
TLS1_k127_4280598_2 carbon dioxide binding K04653,K04654 - - 0.0000000000000000000000000001805 117.0
TLS1_k127_4280598_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.00000000000003831 81.0
TLS1_k127_4280598_4 Enoyl-CoA hydratase/isomerase - - - 0.000000008083 66.0
TLS1_k127_4285283_0 PFAM Amidohydrolase 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000166 225.0
TLS1_k127_4285283_1 KAP family P-loop domain - - - 0.000000000000000000000000000000000000000000002859 185.0
TLS1_k127_4311203_0 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 309.0
TLS1_k127_4311203_1 CHASE3 domain K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000006349 234.0
TLS1_k127_4311203_2 chemotaxis signal transduction protein K03408 - - 0.0000000000000000000000000000000008769 139.0
TLS1_k127_4314146_0 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000005517 174.0
TLS1_k127_4314146_1 signal-transduction protein containing cAMP-binding and CBS domains K07315 - 3.1.3.3 0.00000000000000000001465 100.0
TLS1_k127_4314146_2 nitric oxide dioxygenase activity - - - 0.00000001973 63.0
TLS1_k127_4315076_0 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005556 337.0
TLS1_k127_4315076_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 301.0
TLS1_k127_4315076_2 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000003066 119.0
TLS1_k127_4315076_3 ribonuclease BN K07058 - - 0.000000000000000000000007295 116.0
TLS1_k127_4315076_4 Domain of unknown function (DUF4112) - - - 0.00000000000000000000001045 108.0
TLS1_k127_4315076_5 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00007775 56.0
TLS1_k127_4317758_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 3.916e-288 909.0
TLS1_k127_4317758_1 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000004427 153.0
TLS1_k127_4317758_2 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000001794 66.0
TLS1_k127_4328811_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 330.0
TLS1_k127_4328811_1 - - - - 0.0000000000000000000000000000000000000000000000006435 184.0
TLS1_k127_4328811_2 - - - - 0.0000000000000004647 87.0
TLS1_k127_4330553_0 response to abiotic stimulus - - - 0.000000000000000000000000000000000000000003702 162.0
TLS1_k127_4330553_1 Isochorismate synthase K02552 - 5.4.4.2 0.00000000000000000000000000000000000000002542 159.0
TLS1_k127_4331983_0 B-1 B cell differentiation - - - 0.0000000000000000000000000000000000000000000000000000000000005142 222.0
TLS1_k127_4334392_0 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 310.0
TLS1_k127_4334392_1 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006331 271.0
TLS1_k127_4334392_2 CHRD domain - - - 0.00000000000000001071 88.0
TLS1_k127_4335175_0 VirC1 protein - - - 0.00000000000000000000000000000001053 147.0
TLS1_k127_4335175_1 IrrE N-terminal-like domain - - - 0.00008585 53.0
TLS1_k127_4373351_0 ABC transporter, (ATP-binding protein) K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 313.0
TLS1_k127_4373351_1 extracellular solute-binding protein, family 5 K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004092 283.0
TLS1_k127_4373351_2 ABC-2 family transporter protein K01992 - - 0.0001861 53.0
TLS1_k127_4378834_0 PA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 492.0
TLS1_k127_4378834_1 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 385.0
TLS1_k127_4378834_2 WHG domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000175 242.0
TLS1_k127_4378834_3 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000003578 179.0
TLS1_k127_4397610_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 396.0
TLS1_k127_4397610_1 glycyl-tRNA aminoacylation K01878,K14164 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.0000000000000000000000000000000000000000000000000000281 190.0
TLS1_k127_4405181_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 547.0
TLS1_k127_4405181_1 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.0000000000000000000000000000000001045 139.0
TLS1_k127_4405181_2 Y_Y_Y domain - - - 0.00000000002301 77.0
TLS1_k127_4407890_0 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 374.0
TLS1_k127_4407890_1 Peptidase family M50 - - - 0.0000000000000000006661 96.0
TLS1_k127_4410260_0 Belongs to the citrate synthase family K01647 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 415.0
TLS1_k127_4410260_1 Helix-turn-helix domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 357.0
TLS1_k127_4410260_2 peptidase activity, acting on L-amino acid peptides K20276 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002006 272.0
TLS1_k127_4410260_3 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000000000000000000005825 194.0
TLS1_k127_4410260_4 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000001894 178.0
TLS1_k127_4412421_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 368.0
TLS1_k127_4412421_1 SMART band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002989 362.0
TLS1_k127_4412421_2 response regulator receiver K07668 - - 0.0000000000000000000000000000000000000000000000005247 183.0
TLS1_k127_4412421_3 PhoQ Sensor - - - 0.000000000000000000000000000000000000000003189 175.0
TLS1_k127_4412421_4 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000004835 113.0
TLS1_k127_4412421_5 - - - - 0.00003683 53.0
TLS1_k127_4412421_6 PhoQ Sensor K07678 - 2.7.13.3 0.000144 50.0
TLS1_k127_4412421_7 Trypsin K04771 - 3.4.21.107 0.0002086 51.0
TLS1_k127_4438270_0 Methyltransferase domain - - - 0.00000000000000000000000000001498 128.0
TLS1_k127_4438270_1 PFAM Glycosyl transferase, group 1 - - - 0.0001986 52.0
TLS1_k127_4440317_0 PFAM aminotransferase class V K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006043 342.0
TLS1_k127_4440317_1 Mo-molybdopterin cofactor biosynthetic process - - - 0.00000000000000000000000000000000000000353 158.0
TLS1_k127_4440317_2 Putative capsular polysaccharide synthesis protein - - - 0.00000000000000000000000000000000009236 146.0
TLS1_k127_4440317_3 chaperone-mediated protein folding - - - 0.000000000008364 78.0
TLS1_k127_4451980_0 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 580.0
TLS1_k127_4451980_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008963 523.0
TLS1_k127_4451980_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 505.0
TLS1_k127_4451980_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000008166 266.0
TLS1_k127_4451980_4 Lysophospholipase L1 and related esterases - - - 0.00000000000000000000000000000000000000000000000000000000000000008941 233.0
TLS1_k127_4451980_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000001284 174.0
TLS1_k127_4454570_0 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 304.0
TLS1_k127_4454570_1 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000001946 206.0
TLS1_k127_4454570_2 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000001478 121.0
TLS1_k127_4454570_3 PFAM Iron sulphur-containing domain, CDGSH-type - - - 0.000000000000000002875 86.0
TLS1_k127_4454570_4 Trypsin-like peptidase domain - - - 0.000000000000001808 87.0
TLS1_k127_4467505_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 7.863e-255 800.0
TLS1_k127_4467505_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001362 262.0
TLS1_k127_4467505_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000001177 190.0
TLS1_k127_4467505_3 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000003716 135.0
TLS1_k127_4467768_0 PFAM Peptidase M20 K12941 - - 0.0000000000000000000000000000000000731 139.0
TLS1_k127_4467768_1 helicase activity K06915 - - 0.00000000000000000000000001663 125.0
TLS1_k127_4471463_0 ABC transporter permease K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006628 283.0
TLS1_k127_4471463_1 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000001529 247.0
TLS1_k127_4471516_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009576 421.0
TLS1_k127_4471516_1 Carboxypeptidase regulatory-like domain - - - 0.0000005858 62.0
TLS1_k127_4487460_0 Putative methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 557.0
TLS1_k127_4487460_1 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.00000000000000000000000000000000000000000000000002917 182.0
TLS1_k127_4495214_0 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 319.0
TLS1_k127_4495214_1 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 319.0
TLS1_k127_4495214_2 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007105 292.0
TLS1_k127_4495214_3 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009802 274.0
TLS1_k127_4495214_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000003168 154.0
TLS1_k127_4495214_5 Thioesterase-like superfamily - - - 0.00000000000000000000000000000000000001937 149.0
TLS1_k127_4498885_0 PFAM peptidase M48 Ste24p - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002825 291.0
TLS1_k127_4498885_1 MafB19-like deaminase K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000003002 252.0
TLS1_k127_4498885_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000005531 197.0
TLS1_k127_4498885_3 Protein of unknown function (DUF433) - - - 0.000000000000000000000000001267 113.0
TLS1_k127_4498885_4 - - - - 0.00000000000000000000000001879 112.0
TLS1_k127_4498885_5 Lipopolysaccharide-assembly - - - 0.00000000000000000008694 95.0
TLS1_k127_4498885_6 competence protein - - - 0.00000000000003661 76.0
TLS1_k127_4525646_0 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 402.0
TLS1_k127_4533919_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000003164 153.0
TLS1_k127_4539945_0 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 508.0
TLS1_k127_4539945_1 Lamin Tail Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 486.0
TLS1_k127_4539945_2 PFAM type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 380.0
TLS1_k127_4539945_3 PFAM Type II IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 350.0
TLS1_k127_4539945_4 filamentous hemagglutinin family N-terminal domain - - - 0.0000001222 65.0
TLS1_k127_454078_0 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 533.0
TLS1_k127_454078_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000006346 235.0
TLS1_k127_4551974_0 Protein of unknown function (DUF1016) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 503.0
TLS1_k127_4551974_1 major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007833 408.0
TLS1_k127_4551974_10 - - - - 0.00000001864 59.0
TLS1_k127_4551974_12 BFD-like [2Fe-2S] binding domain K02192 - - 0.00004621 50.0
TLS1_k127_4551974_13 dna polymerase III delta subunit K02340 - 2.7.7.7 0.00008105 55.0
TLS1_k127_4551974_2 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005015 293.0
TLS1_k127_4551974_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001972 263.0
TLS1_k127_4551974_4 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001377 257.0
TLS1_k127_4551974_5 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771 1.16.3.1 0.000000000000000000000000000000000000000000000000000000001532 208.0
TLS1_k127_4551974_6 ErfK ybiS ycfS ynhG family protein K19234 - - 0.000000000000000000000000000000000000000000000000002274 187.0
TLS1_k127_4551974_7 LamB/YcsF family K07160 - - 0.00000000000000000000000000000000000000000000000004644 201.0
TLS1_k127_4551974_8 negative regulation of transcription, DNA-templated K10947 - - 0.00000000000000000000000005289 111.0
TLS1_k127_4557150_0 Belongs to the peptidase S8 family - - - 1.264e-215 689.0
TLS1_k127_4557150_1 Zinc-dependent metalloprotease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000353 493.0
TLS1_k127_4557150_2 LysM domain - - - 0.000000000000000000000009405 108.0
TLS1_k127_4558162_0 TIGRFAM glutaminyl-tRNA synthetase K01886 - 6.1.1.18 8.565e-247 773.0
TLS1_k127_4558162_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000001799 223.0
TLS1_k127_4558162_2 Represses a number of genes involved in the response to DNA damage (SOS response) K01356,K03503 - 3.4.21.88 0.0000000000000000000000000000000000000000000002212 175.0
TLS1_k127_4558162_3 - - - - 0.00000000000000000000000000000000000000000000225 177.0
TLS1_k127_4558162_4 DinB superfamily - - - 0.000000000000003996 81.0
TLS1_k127_4558162_5 Domain of unknown function (DUF4440) - - - 0.00001484 53.0
TLS1_k127_4558162_6 Tetratricopeptide repeat - - - 0.00009244 50.0
TLS1_k127_4558162_7 Helix-turn-helix domain - - - 0.0004252 49.0
TLS1_k127_4572528_0 Protein of unknown function (DUF2400) - - - 0.0000000000000000000000000000000000000000000000000000000000002075 222.0
TLS1_k127_4572528_1 CarboxypepD_reg-like domain - - - 0.00000000000000000000001042 119.0
TLS1_k127_4572528_2 phosphoserine phosphatase activity - - - 0.0000001117 63.0
TLS1_k127_4580695_0 ABC transporter transmembrane K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 497.0
TLS1_k127_4594933_0 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000000000000000000000000006115 228.0
TLS1_k127_4604998_0 tRNA nucleotidyltransferase poly(A) polymerase K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000003011 191.0
TLS1_k127_4604998_1 diguanylate cyclase - - - 0.000000000000000000000000000000000004016 157.0
TLS1_k127_4604998_2 23S rRNA-intervening sequence protein - - - 0.0000000000000000000000000001076 120.0
TLS1_k127_4604998_3 heat shock protein binding - - - 0.0000000000000006999 89.0
TLS1_k127_4604998_4 Glycosyl transferase 4-like domain - - - 0.0003634 51.0
TLS1_k127_4613058_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.203e-220 694.0
TLS1_k127_4616516_0 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000316 203.0
TLS1_k127_4616516_1 Cadherin repeats. - - - 0.000000000000000002073 98.0
TLS1_k127_463126_0 Phosphohydrolase-associated domain K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000005799 195.0
TLS1_k127_463126_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000004274 188.0
TLS1_k127_463126_2 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000001319 98.0
TLS1_k127_4631535_0 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 351.0
TLS1_k127_4631535_1 Two component regulator propeller - - - 0.000000000000000000000000000000000000000000000006061 194.0
TLS1_k127_4631535_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000001334 172.0
TLS1_k127_4631535_3 diguanylate cyclase - - - 0.0000000000000000000000000002019 125.0
TLS1_k127_4631535_4 Protein of unknown function (DUF2721) - - - 0.000000000000000000004329 98.0
TLS1_k127_4631535_5 Transposase - - - 0.0000003453 61.0
TLS1_k127_4631535_6 Dienelactone hydrolase family - - - 0.00001269 55.0
TLS1_k127_4636178_0 Transport permease protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 361.0
TLS1_k127_4636178_1 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 312.0
TLS1_k127_4636178_2 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.000000000000000000000000000000000000000000000000006218 193.0
TLS1_k127_4636178_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000002007 110.0
TLS1_k127_4636178_4 Acetyltransferase (GNAT) domain K22441 GO:0003674,GO:0003824,GO:0004145,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0043937,GO:0043939,GO:0044424,GO:0044464,GO:0048519,GO:0050789,GO:0050793,GO:0051093,GO:0065007 2.3.1.57 0.0002214 49.0
TLS1_k127_4647010_0 Large extracellular alpha-helical protein K06894 - - 9.15e-221 748.0
TLS1_k127_4647010_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 551.0
TLS1_k127_4647010_2 COG1943 Transposase and inactivated derivatives K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000004634 241.0
TLS1_k127_4647010_3 RNA-binding protein - - - 0.00000000000009333 74.0
TLS1_k127_4665074_0 PFAM peptidase M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 295.0
TLS1_k127_4665074_1 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008424 262.0
TLS1_k127_4665848_0 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 342.0
TLS1_k127_4665848_1 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006185 307.0
TLS1_k127_4678582_0 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 317.0
TLS1_k127_4678582_1 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000003825 230.0
TLS1_k127_4678582_2 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000003584 168.0
TLS1_k127_4678582_3 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000114 110.0
TLS1_k127_468098_0 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 300.0
TLS1_k127_468098_1 carboxylic ester hydrolase activity K12132 - 2.7.11.1 0.0000000000000000005458 102.0
TLS1_k127_4684748_0 Conserved hypothetical protein 698 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 338.0
TLS1_k127_4684748_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000001185 240.0
TLS1_k127_4684748_2 Domain of unknown function (DUF4388) - - - 0.000000000000000004701 96.0
TLS1_k127_4686093_0 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000003014 211.0
TLS1_k127_4686093_1 - - - - 0.00000000004353 69.0
TLS1_k127_4686093_2 response regulator - - - 0.000002071 59.0
TLS1_k127_4686093_3 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.00001571 57.0
TLS1_k127_4693081_0 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000007162 219.0
TLS1_k127_4693081_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000001598 200.0
TLS1_k127_4702798_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001699 233.0
TLS1_k127_4702798_1 Protein of Unknown function (DUF2784) - - - 0.000000000000000000000000003401 113.0
TLS1_k127_4702798_2 PFAM Plasmid stabilisation system protein - - - 0.00001643 49.0
TLS1_k127_4702798_3 Putative addiction module component - - - 0.00008661 49.0
TLS1_k127_4712273_0 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 1.515e-244 777.0
TLS1_k127_4712273_1 Alpha-amylase domain K05341,K05343 - 2.4.1.4,3.2.1.1,5.4.99.16 0.00000000000000000000000000000000000000000000000000001302 191.0
TLS1_k127_4717426_0 Beta-lactamase K01256,K17836 - 3.4.11.2,3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000004034 248.0
TLS1_k127_4717426_1 - - - - 0.00000000000000000000000000000000000000000000000000003816 196.0
TLS1_k127_4717426_2 - - - - 0.000000000000000000000000000001119 128.0
TLS1_k127_4719132_0 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000001833 190.0
TLS1_k127_4719132_1 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.000000000000003901 83.0
TLS1_k127_4719132_2 ABC-2 family transporter protein K01992 - - 0.0004062 51.0
TLS1_k127_4728956_0 PFAM Inositol monophosphatase K01092,K05602 - 3.1.3.15,3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000001086 278.0
TLS1_k127_4728956_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000001482 227.0
TLS1_k127_4728956_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000006089 219.0
TLS1_k127_4728956_3 phosphoesterase (MutT family) - - - 0.000000000000000000000000000000000000000211 156.0
TLS1_k127_4728956_4 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000005888 147.0
TLS1_k127_4728956_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family - - - 0.000000000000000000000000000000004481 139.0
TLS1_k127_4728956_6 Protein of unknown function (DUF3313) - - - 0.00000000000000000000000000000002018 137.0
TLS1_k127_4730768_0 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 337.0
TLS1_k127_4730768_1 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.00000000000000000000000000000000000000000000000000001208 207.0
TLS1_k127_474970_0 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000001775 227.0
TLS1_k127_474970_1 - - - - 0.0000000000000000000000000000000003444 145.0
TLS1_k127_474970_2 carboxylic ester hydrolase activity - - - 0.0000000000000000000002611 111.0
TLS1_k127_4752941_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007767 445.0
TLS1_k127_4752941_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000002182 238.0
TLS1_k127_4752941_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000001578 148.0
TLS1_k127_4752941_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.000000000000007811 79.0
TLS1_k127_4752941_4 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000005622 67.0
TLS1_k127_4752941_5 quinone binding K00337 - 1.6.5.3 0.0000001147 57.0
TLS1_k127_4754822_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 448.0
TLS1_k127_4760000_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008046 404.0
TLS1_k127_4760000_1 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008407 370.0
TLS1_k127_4760000_2 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000768 269.0
TLS1_k127_4760000_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000001167 265.0
TLS1_k127_4760000_4 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000003903 174.0
TLS1_k127_4760000_5 PFAM O-antigen polymerase - - - 0.000000431 62.0
TLS1_k127_4768747_0 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009403 263.0
TLS1_k127_4768747_1 OmpA family K03286 - - 0.00000000000000000004518 98.0
TLS1_k127_4772800_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001546 243.0
TLS1_k127_4772800_1 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000008236 242.0
TLS1_k127_4772800_2 AMMECR1 K06990,K09141 - - 0.00000000000000000000000000000000000000000000000001614 185.0
TLS1_k127_4772800_3 PKD domain - - - 0.0000000000000003703 93.0
TLS1_k127_4772800_4 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000002723 84.0
TLS1_k127_4817651_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 555.0
TLS1_k127_4817651_1 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000003043 217.0
TLS1_k127_4817651_2 Belongs to the enoyl-CoA hydratase isomerase family K01782,K01825 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 0.0000000004938 63.0
TLS1_k127_4837028_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008256 376.0
TLS1_k127_4837028_1 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.00000000001114 69.0
TLS1_k127_4837028_2 bacterial OsmY and nodulation domain - - - 0.00002493 53.0
TLS1_k127_4840170_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1042.0
TLS1_k127_4840170_1 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 319.0
TLS1_k127_4840170_2 PFAM chorismate K01665 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000002033 222.0
TLS1_k127_4840170_3 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000003828 224.0
TLS1_k127_4840170_4 Erythromycin esterase K06880 - - 0.000000000000000000000000000000000002526 153.0
TLS1_k127_4840170_5 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000001892 90.0
TLS1_k127_4840170_6 - - - - 0.0000003016 61.0
TLS1_k127_4843495_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 393.0
TLS1_k127_4843495_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000000000000000000000000000000747 216.0
TLS1_k127_4843495_2 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000001245 199.0
TLS1_k127_4843495_3 outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000003769 205.0
TLS1_k127_4843495_4 Cytochrome c K03611 - - 0.00000000000000000000000000000000000000000000000421 180.0
TLS1_k127_4843495_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000004466 153.0
TLS1_k127_4843495_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.000000000000000000000000000000006293 138.0
TLS1_k127_4843495_7 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715,K15866,K20036 - 4.2.1.155,4.2.1.17,5.3.3.18 0.0000000000000000000000012 115.0
TLS1_k127_4843495_8 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.0000003765 61.0
TLS1_k127_4849516_0 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006164 342.0
TLS1_k127_4849516_1 O-Antigen ligase - - - 0.00000000000000000003964 104.0
TLS1_k127_4856501_0 biotin synthase activity - - - 0.0000000000000000000000000004002 127.0
TLS1_k127_4856640_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type K11381 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 422.0
TLS1_k127_4856640_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000003823 222.0
TLS1_k127_4856640_2 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000002688 196.0
TLS1_k127_4856640_3 HIT family hydrolase K02503 - - 0.000003516 55.0
TLS1_k127_4856640_4 - - - - 0.00004022 57.0
TLS1_k127_4876670_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 525.0
TLS1_k127_4876670_1 Peptidase M56 - - - 0.00000000000000001245 97.0
TLS1_k127_4880196_0 glutamine synthetase K01915 - 6.3.1.2 8.493e-217 680.0
TLS1_k127_4880196_1 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00135,K00138,K00146 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.39,1.2.1.79,1.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 576.0
TLS1_k127_4880196_10 EamA-like transporter family - - - 0.00000000000000000006798 91.0
TLS1_k127_4880196_11 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000006908 83.0
TLS1_k127_4880196_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 420.0
TLS1_k127_4880196_3 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009918 352.0
TLS1_k127_4880196_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003065 285.0
TLS1_k127_4880196_5 SIR2-like domain - - - 0.000000000000000000000000000000000000000000000000000000000006946 227.0
TLS1_k127_4880196_6 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001302 191.0
TLS1_k127_4880196_7 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000003754 175.0
TLS1_k127_4880196_8 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000006265 160.0
TLS1_k127_4880196_9 - - - - 0.0000000000000000000001361 107.0
TLS1_k127_4889538_0 YCII-related domain - - - 0.000000000000000000000006867 106.0
TLS1_k127_4889538_1 - - - - 0.000001019 61.0
TLS1_k127_4889538_2 oxidation-reduction process K04782 - 4.2.99.21 0.00006949 48.0
TLS1_k127_4890306_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 375.0
TLS1_k127_4890306_1 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.00000000000000000000000000000000000000000000000000000000003712 213.0
TLS1_k127_4890306_2 L-asparaginase II - - - 0.000000000000000000000000001229 126.0
TLS1_k127_4897070_0 PFAM sulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 327.0
TLS1_k127_4897070_1 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000003935 111.0
TLS1_k127_4897070_2 Thioredoxin - - - 0.00000000000000003729 93.0
TLS1_k127_4897070_3 Ig-like domain from next to BRCA1 gene - - - 0.000000000000003948 90.0
TLS1_k127_4909374_0 Sulfate permease family K01673,K03321 - 4.2.1.1 3.423e-198 632.0
TLS1_k127_4909374_1 histidine kinase dimerisation and phosphoacceptor region K03406,K07673,K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 415.0
TLS1_k127_4909374_2 - - - - 0.00000000000000000000000000000000000000007216 157.0
TLS1_k127_4909748_0 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002709 265.0
TLS1_k127_4909748_1 Enoyl-CoA hydratase carnithine racemase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000009757 154.0
TLS1_k127_4909748_2 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000133 119.0
TLS1_k127_4909787_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 496.0
TLS1_k127_4909787_1 Oligopeptide transporter OPT - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 436.0
TLS1_k127_4933385_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 531.0
TLS1_k127_4936677_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.0 1513.0
TLS1_k127_4936677_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 9.305e-244 781.0
TLS1_k127_4936677_10 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000001939 104.0
TLS1_k127_4936677_11 cyclic nucleotide-binding K01420,K10914 - - 0.0000000000000001447 85.0
TLS1_k127_4936677_12 carbon dioxide binding K04653,K04654 - - 0.00000000000009435 75.0
TLS1_k127_4936677_13 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000333 59.0
TLS1_k127_4936677_14 Transcriptional regulator - - - 0.00001089 53.0
TLS1_k127_4936677_2 Beta-eliminating lyase K01667 - 4.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007565 555.0
TLS1_k127_4936677_3 Elongator protein 3, MiaB family, Radical SAM K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000308 279.0
TLS1_k127_4936677_4 cyclic nucleotide-binding K01420,K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005156 253.0
TLS1_k127_4936677_5 Belongs to the precorrin methyltransferase family K02303,K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000005543 241.0
TLS1_k127_4936677_6 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000001181 216.0
TLS1_k127_4936677_7 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000001846 170.0
TLS1_k127_4936677_8 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000002942 126.0
TLS1_k127_4936677_9 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000003558 116.0
TLS1_k127_4948992_0 Fumarase C C-terminus K01744 - 4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 488.0
TLS1_k127_4948992_1 LigT like Phosphoesterase K01975 - 3.1.4.58 0.0000000000000000003057 97.0
TLS1_k127_4957619_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 514.0
TLS1_k127_4957619_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 488.0
TLS1_k127_4957619_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 441.0
TLS1_k127_4957619_3 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000004006 178.0
TLS1_k127_4957619_4 - - - - 0.00000000000000000000000000006783 117.0
TLS1_k127_4957619_5 AraC-like ligand binding domain - - - 0.000000000000000000000000003367 110.0
TLS1_k127_4965331_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 366.0
TLS1_k127_4965331_1 E1-E2 ATPase K01533,K12950,K17686 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.4,3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 308.0
TLS1_k127_4965331_2 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.0000000000000000000000000000000003694 140.0
TLS1_k127_4965331_3 - - - - 0.0000000000000000000000000000208 122.0
TLS1_k127_4965331_4 - - - - 0.000000000000001664 87.0
TLS1_k127_4965331_5 Cupin domain - - - 0.000000000003264 72.0
TLS1_k127_4965331_6 PFAM cytochrome P450 - - - 0.00000000002181 68.0
TLS1_k127_4970380_0 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 482.0
TLS1_k127_4970380_1 nitrogen compound transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004511 324.0
TLS1_k127_4970380_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 291.0
TLS1_k127_4970380_3 Putative modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000002181 219.0
TLS1_k127_4970380_4 PFAM periplasmic binding protein - - - 0.0000000000000000000000000000000000000000000000001647 186.0
TLS1_k127_4970380_5 - K07018 - - 0.00000000000000000000000000000000000000001916 160.0
TLS1_k127_4970380_6 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.00000000000000000000000008977 111.0
TLS1_k127_4970613_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000001647 196.0
TLS1_k127_4970613_1 Hydrolase - - - 0.0000000000000000000000000000000000006837 147.0
TLS1_k127_4970613_2 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000004971 138.0
TLS1_k127_4970613_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000001681 59.0
TLS1_k127_4979913_0 Amidohydrolase family - - - 0.0 1497.0
TLS1_k127_4979913_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 310.0
TLS1_k127_4979913_2 spore germination - - - 0.00000000000000000000000000000000000000000000000000000001133 209.0
TLS1_k127_4979913_3 SMART Transcription regulator, AsnC-type K03718,K03719 - - 0.000000000000000000000001253 109.0
TLS1_k127_4979913_4 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000002364 71.0
TLS1_k127_4979913_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000005592 58.0
TLS1_k127_4990980_0 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005517 319.0
TLS1_k127_4990980_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000401 219.0
TLS1_k127_4999552_0 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 529.0
TLS1_k127_4999552_1 PFAM FAD dependent oxidoreductase K15736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 453.0
TLS1_k127_4999552_2 Glycosyl transferase K13668 - 2.4.1.346 0.0000000000000000000000000000000000000000000000000000000000000000000000002474 271.0
TLS1_k127_4999552_3 COG0367 Asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000005481 181.0
TLS1_k127_5000376_0 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000002767 216.0
TLS1_k127_5000376_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000004992 173.0
TLS1_k127_5000376_2 Thioesterase superfamily K07107 - - 0.00000007876 59.0
TLS1_k127_5005760_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.866e-308 962.0
TLS1_k127_5005760_1 Amidohydrolase family K01466 - 3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 489.0
TLS1_k127_5005760_2 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001461 263.0
TLS1_k127_5012892_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 518.0
TLS1_k127_5012892_1 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 499.0
TLS1_k127_5012892_2 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 418.0
TLS1_k127_5012892_3 tRNA synthetase B5 domain K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 411.0
TLS1_k127_5012892_4 tRNA synthetases class II core domain (F) K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 340.0
TLS1_k127_5012892_5 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004359 245.0
TLS1_k127_5014472_0 Large exoproteins involved in heme utilization or adhesion K15125 - - 0.000000000000000000000000000009766 141.0
TLS1_k127_5014472_1 RHS Repeat - - - 0.0000000000000000000000001089 128.0
TLS1_k127_5014472_2 RHS Repeat - - - 0.0000001347 68.0
TLS1_k127_5014472_3 SMI1-KNR4 cell-wall - - - 0.00002838 53.0
TLS1_k127_5014504_0 Cytochrome c - - - 2.278e-207 653.0
TLS1_k127_5014504_1 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001505 294.0
TLS1_k127_5014504_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000001486 184.0
TLS1_k127_5014504_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000004749 149.0
TLS1_k127_5014504_4 Domain of unknown function (DUF4252) - - - 0.000000000000000000000000000000000002394 143.0
TLS1_k127_5014504_5 PAS domain K07716,K11357 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.000000000000000000000000000000006291 136.0
TLS1_k127_5014504_6 - - - - 0.000000002303 67.0
TLS1_k127_5016231_0 aminotransferase class I and II K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009752 447.0
TLS1_k127_5016231_1 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 447.0
TLS1_k127_5016231_2 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004117 297.0
TLS1_k127_5016231_3 - - - - 0.00000000000000000000000000000000000000000000000005379 183.0
TLS1_k127_5016231_4 NIPSNAP - - - 0.0000000000000000000000000000002269 124.0
TLS1_k127_5017328_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 349.0
TLS1_k127_5017328_1 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000001825 247.0
TLS1_k127_5018857_0 nuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007138 351.0
TLS1_k127_5018857_1 Periplasmic serine protease - - - 0.000000000000000000000000000000000000000002506 162.0
TLS1_k127_5050214_0 Lipid kinase - - - 0.0000000000000000000000000000000000000000000000000000002829 204.0
TLS1_k127_5050214_1 Domain of unknown function DUF11 - - - 0.00000000000000000000000000000000000000002197 171.0
TLS1_k127_5050214_2 UPF0056 membrane protein K05595 - - 0.00000000000000000000000002255 121.0
TLS1_k127_5071070_0 - - - - 0.0000007921 62.0
TLS1_k127_5073784_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 344.0
TLS1_k127_5073784_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 340.0
TLS1_k127_5073784_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 297.0
TLS1_k127_5073784_3 Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 289.0
TLS1_k127_5087034_0 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000002669 238.0
TLS1_k127_5087034_1 von Willebrand factor type A domain - - - 0.0000000000000000000000003336 120.0
TLS1_k127_5087034_2 tetratricopeptide repeat - - - 0.0006424 50.0
TLS1_k127_5088557_0 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 470.0
TLS1_k127_5088557_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000006894 206.0
TLS1_k127_5088557_2 Tetratricopeptide repeat - - - 0.0000000000000000000000009389 114.0
TLS1_k127_5088557_3 Protein of unknown function DUF86 - - - 0.000000000000000000001936 100.0
TLS1_k127_5088557_4 PFAM DNA polymerase beta domain protein region K07075 - - 0.00000000000000000005004 92.0
TLS1_k127_5088557_5 - - - - 0.000005072 56.0
TLS1_k127_5088605_0 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 389.0
TLS1_k127_5088605_1 Domain of unknown function (DUF1972) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001723 292.0
TLS1_k127_5088605_2 RQC domain - - - 0.000000000000000000000000000000000000000000000000000000001406 207.0
TLS1_k127_5088605_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000008149 168.0
TLS1_k127_5097905_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000348 159.0
TLS1_k127_5097905_1 von Willebrand factor, type A - - - 0.00000000000000000000000000001521 132.0
TLS1_k127_5097905_2 Redoxin domain protein - - - 0.0000000000004509 76.0
TLS1_k127_5098220_0 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001728 279.0
TLS1_k127_5098220_1 Copper binding periplasmic protein CusF K07152 - - 0.00000008294 59.0
TLS1_k127_5123731_0 Divalent cation transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 459.0
TLS1_k127_5123731_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000002817 226.0
TLS1_k127_5123731_2 PFAM Phosphatidic acid phosphatase type 2 haloperoxidase K19302 - 3.6.1.27 0.000000000000000000000000000004366 130.0
TLS1_k127_5123731_3 protein tetramerization K03071 - - 0.000003854 55.0
TLS1_k127_5123771_0 lipoprotein transporter activity K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001979 281.0
TLS1_k127_5123771_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000003614 220.0
TLS1_k127_5123771_2 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000003116 216.0
TLS1_k127_5123771_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000001235 145.0
TLS1_k127_5132394_0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S K00311 - 1.5.5.1 2.28e-198 634.0
TLS1_k127_5132394_1 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 328.0
TLS1_k127_5132394_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005461 273.0
TLS1_k127_5132394_3 Domain of unknown function (DUF3488) - - - 0.00000000000000000000000000000501 138.0
TLS1_k127_5132394_4 Protein of unknown function DUF58 - - - 0.000000000001577 79.0
TLS1_k127_5139197_0 PFAM glycosyl transferase family 39 - - - 0.0000000000006615 81.0
TLS1_k127_5141353_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002659 269.0
TLS1_k127_5141353_1 Extracellular solute-binding protein, family 5 K02035 - - 0.000000000000549 77.0
TLS1_k127_5144982_0 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000007496 216.0
TLS1_k127_5144982_1 histidine kinase HAMP region domain protein K07710 - 2.7.13.3 0.0000000000000000000007982 109.0
TLS1_k127_5144982_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K08084 - - 0.00003094 54.0
TLS1_k127_5151385_0 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001171 288.0
TLS1_k127_5151385_1 Short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000006618 256.0
TLS1_k127_5151385_2 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000000000000000002784 184.0
TLS1_k127_5155178_0 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005882 297.0
TLS1_k127_5155178_1 Patatin-like phospholipase K07001 - - 0.0000000000000007089 91.0
TLS1_k127_5178331_0 Soluble lytic murein transglycosylase K08309 - - 0.0000000000000000000000000000000002756 152.0
TLS1_k127_5178331_1 nuclear chromosome segregation - - - 0.0000000000003394 77.0
TLS1_k127_5178936_0 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.000000000000000000000000000000000000000000000006996 194.0
TLS1_k127_5195608_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.000000000000000000000000000000000000000000000000001692 189.0
TLS1_k127_5195608_1 - - - - 0.000000000000000000000000000001107 130.0
TLS1_k127_5195608_2 - - - - 0.0000000000000000000001087 111.0
TLS1_k127_5197399_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002512 480.0
TLS1_k127_5197399_1 Enoyl-(Acyl carrier protein) reductase K00023,K00059 - 1.1.1.100,1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000306 222.0
TLS1_k127_5197399_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000000000000000000000000002888 217.0
TLS1_k127_5197399_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000001098 130.0
TLS1_k127_5197399_4 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02341 - 2.7.7.7 0.0000008097 60.0
TLS1_k127_5200654_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. K14980 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000005396 231.0
TLS1_k127_5200654_1 Fungalysin metallopeptidase (M36) - - - 0.00000000000000000000000000000000000000000000000003299 205.0
TLS1_k127_5200654_2 regulator of chromosome condensation, RCC1 - - - 0.0000000000001277 85.0
TLS1_k127_5212206_0 glutamate carboxypeptidase K01301 - 3.4.17.21 3.066e-287 899.0
TLS1_k127_5212206_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 582.0
TLS1_k127_5212206_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000006148 134.0
TLS1_k127_5212206_3 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.0000000003214 61.0
TLS1_k127_5212206_4 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00002898 55.0
TLS1_k127_5212610_0 HAMP domain - - - 0.000000000000004185 79.0
TLS1_k127_5212610_1 protein transport across the cell outer membrane K02246,K08084 - - 0.000000008372 64.0
TLS1_k127_5215059_0 transporter - - - 3.3e-274 867.0
TLS1_k127_5215059_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.457e-256 821.0
TLS1_k127_5215059_10 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 332.0
TLS1_k127_5215059_11 AMP-binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000003733 242.0
TLS1_k127_5215059_12 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.00000000000000000000000000000000000000000000003699 181.0
TLS1_k127_5215059_13 membrane - - - 0.000000000000000000000000000000000000003844 165.0
TLS1_k127_5215059_14 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000498 112.0
TLS1_k127_5215059_15 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000001974 106.0
TLS1_k127_5215059_16 PspC domain - - - 0.000000000000000001104 91.0
TLS1_k127_5215059_17 VanZ like family - - - 0.0000000000005641 76.0
TLS1_k127_5215059_18 - - - - 0.00000002714 59.0
TLS1_k127_5215059_19 His Kinase A (phosphoacceptor) domain - - - 0.0000004928 59.0
TLS1_k127_5215059_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.016e-247 790.0
TLS1_k127_5215059_20 - - - - 0.00000189 59.0
TLS1_k127_5215059_21 COG1560 Lauroyl myristoyl acyltransferase K02517 - 2.3.1.241 0.0000501 55.0
TLS1_k127_5215059_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 4.505e-239 751.0
TLS1_k127_5215059_4 Predicted membrane protein (DUF2339) - - - 1.315e-217 717.0
TLS1_k127_5215059_5 Guanine deaminase K01487 - 3.5.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 490.0
TLS1_k127_5215059_6 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 469.0
TLS1_k127_5215059_7 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 434.0
TLS1_k127_5215059_8 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006622 441.0
TLS1_k127_5215059_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 418.0
TLS1_k127_5216518_0 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000728 320.0
TLS1_k127_5216518_1 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000001244 120.0
TLS1_k127_5216518_2 TIGRFAM Phosphohistidine phosphatase SixA K08296 - - 0.000000000002375 75.0
TLS1_k127_5226799_0 Belongs to the peptidase M10A family K07761,K07999 GO:0001101,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009628,GO:0009651,GO:0009719,GO:0009725,GO:0009753,GO:0010033,GO:0010035,GO:0010038,GO:0016020,GO:0016787,GO:0019538,GO:0031224,GO:0031225,GO:0032502,GO:0040007,GO:0042221,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046686,GO:0048519,GO:0048580,GO:0048583,GO:0048589,GO:0048831,GO:0050789,GO:0050793,GO:0050896,GO:0051093,GO:0051239,GO:0051241,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080186,GO:0140096,GO:1900055,GO:1900056,GO:1901564,GO:1901700,GO:1905622,GO:2000024,GO:2000026,GO:2000028,GO:2000241 - 0.00000007795 61.0
TLS1_k127_522972_0 cobalamin-transporting ATPase activity K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000001307 218.0
TLS1_k127_522972_1 DinB superfamily - - - 0.000000000000000000000000000000000004519 143.0
TLS1_k127_5250918_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 1.319e-202 639.0
TLS1_k127_5250918_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000002621 189.0
TLS1_k127_5250918_2 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000002275 109.0
TLS1_k127_5250918_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.000000000000000003327 90.0
TLS1_k127_5250918_4 Histidine kinase - - - 0.0000000000003864 80.0
TLS1_k127_5250918_5 Synaptosomal-associated protein 47 K18212 GO:0000149,GO:0001505,GO:0003674,GO:0005484,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006810,GO:0006836,GO:0006886,GO:0006887,GO:0006906,GO:0006996,GO:0007154,GO:0007267,GO:0007268,GO:0007269,GO:0008021,GO:0008104,GO:0008150,GO:0009987,GO:0010646,GO:0010647,GO:0012505,GO:0012506,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016050,GO:0016079,GO:0016082,GO:0016192,GO:0017156,GO:0019905,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0023061,GO:0030133,GO:0030425,GO:0030658,GO:0030659,GO:0030672,GO:0031090,GO:0031201,GO:0031410,GO:0031503,GO:0031629,GO:0031982,GO:0032594,GO:0032940,GO:0032991,GO:0033036,GO:0034613,GO:0034622,GO:0035418,GO:0036477,GO:0042886,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043227,GO:0043229,GO:0043933,GO:0044085,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044433,GO:0044444,GO:0044446,GO:0044456,GO:0044463,GO:0044464,GO:0045026,GO:0045055,GO:0045184,GO:0045202,GO:0046903,GO:0046907,GO:0048167,GO:0048284,GO:0048489,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050804,GO:0050806,GO:0051179,GO:0051234,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051656,GO:0051668,GO:0060291,GO:0061024,GO:0061025,GO:0065003,GO:0065007,GO:0065008,GO:0070382,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0090174,GO:0097120,GO:0097447,GO:0097458,GO:0097479,GO:0097480,GO:0097708,GO:0098588,GO:0098793,GO:0098796,GO:0098805,GO:0098876,GO:0098877,GO:0098881,GO:0098916,GO:0098967,GO:0098969,GO:0099003,GO:0099072,GO:0099177,GO:0099500,GO:0099501,GO:0099503,GO:0099504,GO:0099536,GO:0099537,GO:0099632,GO:0099637,GO:0099643,GO:0120025,GO:0120038,GO:0140029,GO:1903539,GO:1903540,GO:1990778 - 0.0005953 46.0
TLS1_k127_5280462_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.177e-226 726.0
TLS1_k127_5280462_1 Pectate lyase K01732,K02316,K13590,K20276,K20541 - 2.7.7.65,4.2.2.10 0.00000000005002 75.0
TLS1_k127_5280462_2 Modulates RecA activity K03565 - - 0.000000001461 67.0
TLS1_k127_5280833_0 Putative methyltransferase - - - 1.489e-194 623.0
TLS1_k127_5280833_1 Protein kinase domain K08884 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000572 372.0
TLS1_k127_5280833_2 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000009575 203.0
TLS1_k127_5280833_3 Acyl-transferase - - - 0.000000000000000000000000000000000000000000000000008545 190.0
TLS1_k127_5280833_4 cdp-diacylglycerol--glycerol-3-phosphate - - - 0.000000000000000000000000001544 122.0
TLS1_k127_5280833_5 Protein of unknown function (DUF3574) - - - 0.000000000000000001115 91.0
TLS1_k127_5304734_0 COG0553 Superfamily II DNA RNA - - - 3.29e-275 872.0
TLS1_k127_5305268_0 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000003412 200.0
TLS1_k127_5305268_1 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000004843 113.0
TLS1_k127_5305318_0 Cna B domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 428.0
TLS1_k127_5305318_1 response to heat K03668 - - 0.0000000000001184 78.0
TLS1_k127_5305833_0 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 379.0
TLS1_k127_5305833_1 ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008158 273.0
TLS1_k127_5322920_0 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K07713,K07714,K19641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000989 494.0
TLS1_k127_5322920_1 PFAM Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 505.0
TLS1_k127_5322920_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002912 268.0
TLS1_k127_5329649_0 ABC1 family K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 420.0
TLS1_k127_5329649_1 trisaccharide binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 396.0
TLS1_k127_534287_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 3.027e-237 762.0
TLS1_k127_5355791_0 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007547 396.0
TLS1_k127_5355791_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000001212 238.0
TLS1_k127_5355791_2 Aminotransferase class-V K04487 GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 0.000000000000000000000000000000000000000006214 159.0
TLS1_k127_5359055_0 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 412.0
TLS1_k127_5359055_1 Transport permease protein K01992,K09690 - - 0.0000000005948 63.0
TLS1_k127_5359055_2 PFAM HD domain - - - 0.00000006972 62.0
TLS1_k127_5365839_0 Cytochrome b(N-terminal)/b6/petB K00410,K00412,K02635,K02637 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 396.0
TLS1_k127_5365839_1 Rieske [2Fe-2S] domain K00411,K02636,K03886 - 1.10.2.2,1.10.9.1 0.000000000003851 67.0
TLS1_k127_536758_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 461.0
TLS1_k127_5383717_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 4.782e-312 972.0
TLS1_k127_5383717_1 GGDEF domain - - - 0.000000000000000000000000000000000000000000001753 178.0
TLS1_k127_5383717_2 electron transfer activity K02305,K08738,K17223 - - 0.000000000000000001471 90.0
TLS1_k127_5383717_3 Response regulator receiver - - - 0.000000000000006917 81.0
TLS1_k127_5387835_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 483.0
TLS1_k127_5387835_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - 0.000000000000000000000000000000000007816 147.0
TLS1_k127_5387835_2 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0001677 48.0
TLS1_k127_5388940_0 type I phosphodiesterase nucleotide pyrophosphatase - GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 - 0.000000000000000000000000000000000000000000000000000000033 216.0
TLS1_k127_5389793_0 FeS assembly protein SufB K09014 - - 1.558e-256 797.0
TLS1_k127_5389793_1 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006799 575.0
TLS1_k127_5389793_2 TIGRFAM FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 376.0
TLS1_k127_5389793_3 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 345.0
TLS1_k127_5389793_4 FeS assembly SUF system protein SufT - - - 0.000000000000000000000000000000000000000000000000000000622 198.0
TLS1_k127_5389793_5 SUF system FeS assembly protein K04488 - - 0.0000000000000000000000000000000000000000000000000008666 186.0
TLS1_k127_5389793_6 protein kinase activity - - - 0.0000000000000000000000000000000000000000002172 183.0
TLS1_k127_5389793_7 MTH538 TIR-like domain (DUF1863) K12132 - 2.7.11.1 0.00000000000000000000000000000009497 145.0
TLS1_k127_5389793_8 Transcriptional regulator - - - 0.00000000000000000000000009327 113.0
TLS1_k127_5394302_0 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 300.0
TLS1_k127_5394302_1 protein secretion by the type IV secretion system K00564,K02026,K10716,K11070,K13924,K14393 - 2.1.1.172,2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000003253 258.0
TLS1_k127_5394302_2 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002785 245.0
TLS1_k127_5398266_0 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 574.0
TLS1_k127_5398266_1 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000001415 209.0
TLS1_k127_5398266_2 - - - - 0.000000000009057 67.0
TLS1_k127_5426588_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 563.0
TLS1_k127_5443012_0 RmuC family K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 398.0
TLS1_k127_5443012_1 AbiEi antitoxin C-terminal domain - - - 0.0000000000000000000000008489 109.0
TLS1_k127_5447490_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 594.0
TLS1_k127_5447490_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 520.0
TLS1_k127_5447490_2 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000000000000000003298 184.0
TLS1_k127_5447490_3 Domain of Unknown Function (DUF350) - - - 0.000000000004189 71.0
TLS1_k127_5450288_0 PHP domain protein K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 401.0
TLS1_k127_5450288_1 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000004475 216.0
TLS1_k127_5450288_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000002217 213.0
TLS1_k127_5450288_3 Belongs to the peptidase S11 family K07258 GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.16.4 0.00000000000000000000000000000000000000000000000000003619 203.0
TLS1_k127_5460950_0 Nacht domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009992 318.0
TLS1_k127_547390_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 417.0
TLS1_k127_547390_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 336.0
TLS1_k127_547390_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000341 55.0
TLS1_k127_547538_0 Dipeptidyl carboxypeptidase K01284 - 3.4.15.5 3.174e-276 869.0
TLS1_k127_547538_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 521.0
TLS1_k127_547538_2 ADP-glyceromanno-heptose 6-epimerase activity K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 492.0
TLS1_k127_547538_3 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004229 263.0
TLS1_k127_547538_4 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000007802 236.0
TLS1_k127_547538_5 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.000000000000000000000000000000000000000521 164.0
TLS1_k127_547538_6 - - - - 0.00000000000000000008395 95.0
TLS1_k127_5489663_0 Flavin-binding monooxygenase-like K07222 - - 0.000000000000000000000000000000000000000000000000000000000007815 221.0
TLS1_k127_5489663_1 - - - - 0.000000000009171 71.0
TLS1_k127_5507068_0 Dihydroorotate dehydrogenase K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 303.0
TLS1_k127_5507068_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000889 284.0
TLS1_k127_5507068_2 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000000000001649 163.0
TLS1_k127_5507068_4 Belongs to the ompA family - - - 0.000000000000000000000000000005873 134.0
TLS1_k127_5507068_5 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000003413 61.0
TLS1_k127_5507068_6 PFAM von Willebrand factor type A K07114 - - 0.000000004036 68.0
TLS1_k127_5518327_0 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008789 580.0
TLS1_k127_5518327_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.000000000000000000000000000000000000000000000000000000000000000003723 229.0
TLS1_k127_5520595_0 amine dehydrogenase activity K20276 - - 0.0000000000000000000000000007921 124.0
TLS1_k127_5520595_1 - - - - 0.000000000000000000000001413 114.0
TLS1_k127_5520595_2 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00000000000000000000008444 112.0
TLS1_k127_5520595_3 guanyl-nucleotide exchange factor activity K05349,K13735,K18491,K20276 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.2.1.21 0.000000000000004698 88.0
TLS1_k127_5522855_0 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 398.0
TLS1_k127_5522855_1 AAA domain - - - 0.0000000000000000000000003329 111.0
TLS1_k127_5522855_2 Protein of unknown function (DUF3800) - - - 0.0000000000000000000003073 106.0
TLS1_k127_5524725_0 Uncharacterized protein conserved in bacteria (DUF2200) - - - 0.0000000000000000000000000000000000000000000000000000000000009966 210.0
TLS1_k127_5524725_1 Belongs to the peptidase S41A family - - - 0.00000000000000000000000000000000000000000000001296 188.0
TLS1_k127_5524725_2 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.000000000000000000000000000000000000007375 156.0
TLS1_k127_5524725_3 Acetyltransferase - - - 0.00000000000000000000000000000000007052 140.0
TLS1_k127_5524725_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000003791 123.0
TLS1_k127_5524725_5 Glyoxalase-like domain - - - 0.0000000000000000000000000001217 120.0
TLS1_k127_5524725_6 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000388 82.0
TLS1_k127_5524725_7 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000929 78.0
TLS1_k127_5524725_8 PEGA domain - - - 0.0003713 50.0
TLS1_k127_5528396_0 helicase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 490.0
TLS1_k127_5528396_1 amino acid activation for nonribosomal peptide biosynthetic process K03641,K20276 - - 0.000000000000000000000000000000000000000001115 174.0
TLS1_k127_5532908_0 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006113 269.0
TLS1_k127_5532908_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000008864 214.0
TLS1_k127_5532908_2 TIGRFAM Outer membrane assembly lipoprotein YfiO K05807 - - 0.00000000000000000000431 104.0
TLS1_k127_5532908_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000004311 97.0
TLS1_k127_5532908_4 PASTA K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.0000009906 59.0
TLS1_k127_5543291_0 Leukotriene A4 hydrolase, C-terminal - - - 6.712e-204 660.0
TLS1_k127_5543291_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 579.0
TLS1_k127_5543291_10 PFAM S23 ribosomal protein - - - 0.0000008974 54.0
TLS1_k127_5543291_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 553.0
TLS1_k127_5543291_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 482.0
TLS1_k127_5543291_4 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 415.0
TLS1_k127_5543291_5 Cysteine dioxygenase type I K00456 - 1.13.11.20 0.0000000000000000000000000000000000000000000000000000002424 201.0
TLS1_k127_5543291_6 Domain of unknown function (DUF3291) - - - 0.000000000000000000000000000000000000000000000000000008301 200.0
TLS1_k127_5543291_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000002244 160.0
TLS1_k127_5543291_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000002843 153.0
TLS1_k127_5543291_9 PFAM Helix-turn-helix - - - 0.00000000000000000000000002247 113.0
TLS1_k127_5543685_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000008727 220.0
TLS1_k127_5543685_1 GIY-YIG catalytic domain K07461 - - 0.00000000000000000000002532 103.0
TLS1_k127_5552576_0 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 519.0
TLS1_k127_5552576_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007738 394.0
TLS1_k127_556646_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 559.0
TLS1_k127_556646_1 nuclear-transcribed mRNA catabolic process, no-go decay - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 421.0
TLS1_k127_556646_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005403 358.0
TLS1_k127_556646_3 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000000002257 231.0
TLS1_k127_556646_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000379 204.0
TLS1_k127_556646_5 Calcium/calmodulin dependent protein kinase II association domain - - - 0.000000000000000000000000000000000000000000006775 166.0
TLS1_k127_556646_6 PFAM OmpA MotB domain protein K03640 - - 0.00000000000000000000000000000000000003334 149.0
TLS1_k127_556646_7 helix_turn_helix, Lux Regulon - - - 0.0008282 42.0
TLS1_k127_5577159_0 GTP binding K06942 GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - 0.000000000000000000000000000000000000000000000000002336 185.0
TLS1_k127_5577159_1 - - - - 0.00000000000000000000000000000000000000000000007815 178.0
TLS1_k127_5577159_3 tetratricopeptide repeat - - - 0.000000000000000000002167 106.0
TLS1_k127_5577159_4 - - - - 0.0000000000000000006433 93.0
TLS1_k127_5577159_5 PilT protein domain protein - - - 0.0000000000002185 76.0
TLS1_k127_5578054_0 SWIM zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 609.0
TLS1_k127_5578054_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 426.0
TLS1_k127_5585041_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001878 247.0
TLS1_k127_5585041_1 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000004236 230.0
TLS1_k127_5585041_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0006485 52.0
TLS1_k127_5595019_0 PFAM peptidase M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 593.0
TLS1_k127_5595019_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000001042 104.0
TLS1_k127_5595019_2 ATP-binding protein K04562 - - 0.0000000000000000000000378 113.0
TLS1_k127_5618266_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007577 441.0
TLS1_k127_5618266_1 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 GO:0001882,GO:0001884,GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0036094,GO:0042454,GO:0042802,GO:0043094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047844,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.5.4.5 0.000000000000000000000000000000000000000000000000000000000000000004763 234.0
TLS1_k127_5618266_2 - - - - 0.000000000000000000000000000000000000000000000000000006954 207.0
TLS1_k127_5618266_3 Protein of unknown function (DUF3467) - - - 0.00000000000000000002734 94.0
TLS1_k127_5618314_0 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 347.0
TLS1_k127_5618314_1 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000000000000000000000000000000000000000000000000000000000198 237.0
TLS1_k127_5622279_0 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005264 243.0
TLS1_k127_5622279_1 Protein of unknown function (DUF3800) - - - 0.000000000000000000000000000000000000000003652 165.0
TLS1_k127_5622279_2 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000001596 123.0
TLS1_k127_5622279_3 Dihydroorotate dehydrogenase K00254 - 1.3.5.2 0.0000000000000007239 86.0
TLS1_k127_5622279_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000001606 85.0
TLS1_k127_5633735_0 Carboxypeptidase regulatory-like domain - - - 2.622e-310 981.0
TLS1_k127_5633735_1 Protein of unknown function (DUF1304) K08987 - - 0.00000000000000000000000000000000000000003005 158.0
TLS1_k127_5642984_0 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 319.0
TLS1_k127_5642984_1 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002181 261.0
TLS1_k127_5642984_2 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000818 178.0
TLS1_k127_5650866_0 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 510.0
TLS1_k127_5650866_1 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 358.0
TLS1_k127_5650866_2 iron ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 306.0
TLS1_k127_5650866_3 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 300.0
TLS1_k127_5650866_4 RNA pseudouridylate synthase K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 292.0
TLS1_k127_5650866_5 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001945 261.0
TLS1_k127_5650866_6 PD-(D/E)XK nuclease superfamily - - - 0.0000000000000000000000000000000000001149 144.0
TLS1_k127_5650866_7 - - - - 0.0000000000000000000001354 103.0
TLS1_k127_5650866_8 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000003434 78.0
TLS1_k127_5651091_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 397.0
TLS1_k127_56576_0 Domain of unknown function (DUF5117) - - - 7.998e-226 724.0
TLS1_k127_5658911_0 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 390.0
TLS1_k127_5658911_1 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006115 336.0
TLS1_k127_5658911_2 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000006281 166.0
TLS1_k127_5674882_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.994e-216 698.0
TLS1_k127_5674882_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009233 408.0
TLS1_k127_5674882_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007917 335.0
TLS1_k127_5674882_3 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000002119 91.0
TLS1_k127_5674882_4 Fibronectin type 3 domain - - - 0.000000000002404 80.0
TLS1_k127_5674882_5 COGs COG5305 membrane protein - - - 0.0003317 53.0
TLS1_k127_5692673_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 3.382e-211 679.0
TLS1_k127_5692673_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 541.0
TLS1_k127_5692673_2 RES - - - 0.0000000000000000000000000000000000005091 147.0
TLS1_k127_5692673_3 Protein of unknown function (DUF2384) - - - 0.00000000000000000003142 99.0
TLS1_k127_5720106_0 PASTA domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 447.0
TLS1_k127_5720106_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 293.0
TLS1_k127_5720106_2 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000009664 150.0
TLS1_k127_5720106_3 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000000000000001526 141.0
TLS1_k127_5720106_4 Protein of unknown function (DUF1232) - - - 0.000002494 52.0
TLS1_k127_5727796_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000002182 240.0
TLS1_k127_5727796_1 - - - - 0.0000000000000000000000000000000000000000000000002816 186.0
TLS1_k127_5727796_2 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000007048 128.0
TLS1_k127_5727796_3 - - - - 0.000000000000000001262 99.0
TLS1_k127_5745136_0 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000188 165.0
TLS1_k127_5745136_1 Methyltransferase domain - - - 0.0000000000000000000001408 105.0
TLS1_k127_5754362_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 453.0
TLS1_k127_5754362_1 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007422 358.0
TLS1_k127_5754362_2 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000004133 186.0
TLS1_k127_5754362_3 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000001398 172.0
TLS1_k127_5754362_4 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000000000000002709 152.0
TLS1_k127_5769705_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 3.415e-201 640.0
TLS1_k127_5769705_1 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 342.0
TLS1_k127_5769705_2 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 303.0
TLS1_k127_5769705_3 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000001148 201.0
TLS1_k127_5769705_4 peroxiredoxin, OsmC subfamily K04063 - - 0.000000000000000000000000000000000000000000000000001692 189.0
TLS1_k127_5769705_5 TIGRFAM TonB K03832 - - 0.0000000000000008279 88.0
TLS1_k127_5769705_6 Tetratricopeptide repeat - - - 0.000000000004313 78.0
TLS1_k127_5769705_7 cheY-homologous receiver domain - - - 0.00000000007916 73.0
TLS1_k127_5782955_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 605.0
TLS1_k127_5782955_1 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 501.0
TLS1_k127_5782955_2 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004769 292.0
TLS1_k127_5782955_3 PFAM Nucleotidyltransferase domain K07075 - - 0.0000000000000000000000000002812 116.0
TLS1_k127_5782955_4 Phosphodiester glycosidase - - - 0.0000000000000000000000000007718 123.0
TLS1_k127_5782955_5 Protein of unknown function DUF86 - - - 0.0000000000000000000009614 98.0
TLS1_k127_5782955_6 peptidase U62, modulator of DNA gyrase - - - 0.00000007254 60.0
TLS1_k127_5793337_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 318.0
TLS1_k127_5793337_1 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.00000000000000000000000000000000000000001685 172.0
TLS1_k127_5793337_2 CoA binding domain K06929 - - 0.000000000000000000000006727 101.0
TLS1_k127_5793337_3 Alpha beta hydrolase - - - 0.00000000000000002357 96.0
TLS1_k127_5793337_4 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.000000005299 62.0
TLS1_k127_5795248_0 Cytochrome c-type biogenesis protein K02198 - - 4.804e-200 642.0
TLS1_k127_5795248_1 Redoxin K02199 - - 0.00000000000000000000000000000000000000000002762 172.0
TLS1_k127_5795248_2 subunit of a heme lyase K02200 - - 0.000000000000000000002028 106.0
TLS1_k127_5795248_3 COG4235 Cytochrome c biogenesis factor K02200 - - 0.00003399 57.0
TLS1_k127_5797594_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000594 393.0
TLS1_k127_5797594_1 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.0000000000000000000000000000000000000000000000000000000000000006574 236.0
TLS1_k127_5805506_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 485.0
TLS1_k127_5805506_1 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005732 253.0
TLS1_k127_5805506_2 2 iron, 2 sulfur cluster binding K07302,K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000007115 214.0
TLS1_k127_5805506_3 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000008956 220.0
TLS1_k127_5816385_0 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000004161 126.0
TLS1_k127_5816385_1 metalloendopeptidase activity - - - 0.000000001387 65.0
TLS1_k127_583320_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 407.0
TLS1_k127_583320_1 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001922 293.0
TLS1_k127_583320_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000003116 202.0
TLS1_k127_583320_3 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000001842 139.0
TLS1_k127_583320_4 Protein of unknown function (DUF2384) - - - 0.00000002256 58.0
TLS1_k127_5887319_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007664 428.0
TLS1_k127_5887319_1 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000004021 176.0
TLS1_k127_5887319_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000001186 53.0
TLS1_k127_591693_0 oligosaccharyl transferase activity - - - 0.000000000000000000000009245 115.0
TLS1_k127_591693_1 Regulatory protein, FmdB - - - 0.00000000000000003878 88.0
TLS1_k127_591693_2 nuclear chromosome segregation - - - 0.000000005931 67.0
TLS1_k127_591693_3 belongs to the thioredoxin family - - - 0.0000006615 59.0
TLS1_k127_591693_4 - - - - 0.000003069 55.0
TLS1_k127_591693_5 Tetratricopeptide repeats - - - 0.0005593 49.0
TLS1_k127_5948093_0 Pfam:Methyltransf_26 - - - 1.871e-274 868.0
TLS1_k127_5948093_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 307.0
TLS1_k127_5948093_2 - - - - 0.000000000000000000000000000000000000000002482 173.0
TLS1_k127_5948093_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K04068,K10026 - 1.97.1.4,4.3.99.3 0.0000000000000000000000000000000824 126.0
TLS1_k127_5955350_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1631.0
TLS1_k127_5955350_1 Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 460.0
TLS1_k127_5955350_10 - - - - 0.0000000000000000000000000000000005959 140.0
TLS1_k127_5955350_11 - - - - 0.00000000000000000000000000001265 124.0
TLS1_k127_5955350_12 PFAM SpoVT AbrB K07172 - - 0.00000000000000000009861 91.0
TLS1_k127_5955350_13 - - - - 0.000000000000005471 86.0
TLS1_k127_5955350_14 - - - - 0.0000000000002048 74.0
TLS1_k127_5955350_15 protein kinase activity K08884 - 2.7.11.1 0.0000000000007324 83.0
TLS1_k127_5955350_16 heme-binding sites - - - 0.000000000005461 79.0
TLS1_k127_5955350_17 Belongs to the glycosyl hydrolase 18 family K01179,K01183 - 3.2.1.14,3.2.1.4 0.000000000129 76.0
TLS1_k127_5955350_18 - - - - 0.000000001134 65.0
TLS1_k127_5955350_19 Transcriptional regulator - - - 0.0000003065 55.0
TLS1_k127_5955350_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 434.0
TLS1_k127_5955350_20 Protein of unknown function (DUF499) K06922 - - 0.00002387 48.0
TLS1_k127_5955350_21 HNH endonuclease K07454 - - 0.0007563 44.0
TLS1_k127_5955350_3 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 328.0
TLS1_k127_5955350_4 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 301.0
TLS1_k127_5955350_5 regulation of methylation-dependent chromatin silencing K03684,K09968 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 289.0
TLS1_k127_5955350_6 Uncharacterized BCR, YaiI/YqxD family COG1671 K09768 - - 0.000000000000000000000000000000000000000000000000000005557 195.0
TLS1_k127_5955350_7 COG1078 HD superfamily K06885 - - 0.000000000000000000000000000000000000000002113 179.0
TLS1_k127_5955350_8 - - - - 0.000000000000000000000000000000000000001224 160.0
TLS1_k127_5955350_9 PIN domain K18828 - - 0.00000000000000000000000000000000001567 139.0
TLS1_k127_5973792_0 methyltransferase activity K00569,K16437,K21336 - 2.1.1.67 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 513.0
TLS1_k127_5973792_1 pfam abc K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 407.0
TLS1_k127_5973792_11 Glycosyl transferase group 1 - - - 0.00000000000000000002003 100.0
TLS1_k127_5973792_12 Glycosyl transferases group 1 - - - 0.0000000000000002877 91.0
TLS1_k127_5973792_13 Glycosyl transferases group 1 - - - 0.000000000000003774 88.0
TLS1_k127_5973792_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 400.0
TLS1_k127_5973792_3 Polysaccharide biosynthesis protein K13318,K13322,K16439,K19857 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008616 392.0
TLS1_k127_5973792_4 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 347.0
TLS1_k127_5973792_5 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 295.0
TLS1_k127_5973792_6 RmlD substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002012 235.0
TLS1_k127_5973792_7 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000007684 179.0
TLS1_k127_5973792_8 Methyltransferase domain - - - 0.00000000000000000000000000000004558 138.0
TLS1_k127_5973792_9 - - - - 0.00000000000000000000000000000005776 138.0
TLS1_k127_597522_0 Belongs to the allantoicase family K01477 - 3.5.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 545.0
TLS1_k127_597522_1 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.000000000000000000000000000000006561 135.0
TLS1_k127_5982925_0 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000004043 191.0
TLS1_k127_5982925_1 Glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000001791 167.0
TLS1_k127_5982925_2 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000000000001983 121.0
TLS1_k127_5982925_3 Glycosyltransferase like family 2 K07011 - - 0.000000000000000000002156 105.0
TLS1_k127_5988072_0 Competence protein ComEC K02238 - - 0.0000000000000000000000000000000000000000000000000000007113 216.0
TLS1_k127_5988072_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000006166 194.0
TLS1_k127_5988072_2 S1/P1 Nuclease - - - 0.0000000000000000000000000000000000000003019 163.0
TLS1_k127_599215_0 Castor and Pollux, part of voltage-gated ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005268 539.0
TLS1_k127_5999111_0 GGDEF domain - - - 0.00000000000000000000000000000000000000000002911 175.0
TLS1_k127_5999111_1 Dual specificity phosphatase, catalytic domain K01090 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.1.3.16 0.00000000000000000000001789 101.0
TLS1_k127_5999111_2 - - - - 0.00000001036 64.0
TLS1_k127_6002083_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000051 340.0
TLS1_k127_6002083_1 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005686 263.0
TLS1_k127_6016357_0 Peptidase family M1 domain - - - 1.929e-210 684.0
TLS1_k127_6021610_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 435.0
TLS1_k127_6021610_1 SWI complex, BAF60b domains - - - 0.000000000000000000000000000000005866 129.0
TLS1_k127_6021610_2 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000001775 61.0
TLS1_k127_6021610_3 Membrane - - - 0.000008866 56.0
TLS1_k127_6025995_0 Phage integrase, N-terminal SAM-like domain K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000009056 241.0
TLS1_k127_6025995_1 Protein of unknown function (DUF433) - - - 0.00000000000000000000000000000000000000000001141 171.0
TLS1_k127_6025995_2 PAP2 superfamily - - - 0.0000000000000256 74.0
TLS1_k127_6025995_3 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000001357 68.0
TLS1_k127_6025995_4 - - - - 0.000000000002095 76.0
TLS1_k127_6052578_0 glutamate-cysteine ligase activity K06048 GO:0003674,GO:0003824,GO:0016874,GO:0016879 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 477.0
TLS1_k127_6052578_1 ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 347.0
TLS1_k127_6052578_2 esterase - - - 0.000000000000000000000000000000000000000000000000000000000000003162 225.0
TLS1_k127_6052578_3 GMP synthase-glutamine amidotransferase - - - 0.0001064 53.0
TLS1_k127_6058005_0 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 5.026e-223 698.0
TLS1_k127_6058005_1 PFAM Glycoside hydrolase 15-related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 564.0
TLS1_k127_6058005_2 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009294 378.0
TLS1_k127_6058005_3 ORF located using - - - 0.0000000000000000001035 100.0
TLS1_k127_6058005_4 - - - - 0.0000000000000001327 90.0
TLS1_k127_6058005_5 - - - - 0.00000000003448 74.0
TLS1_k127_6058110_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 7.022e-316 986.0
TLS1_k127_6058110_1 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000002402 180.0
TLS1_k127_6058110_2 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000009661 174.0
TLS1_k127_6058110_4 Belongs to the sigma-70 factor family - - - 0.000004785 48.0
TLS1_k127_6068990_0 Carbamoyl-phosphate synthetase large chain domain protein K01955 - 6.3.5.5 0.0 1347.0
TLS1_k127_6069026_0 Coenzyme A transferase K01029 - 2.8.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 325.0
TLS1_k127_6069026_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000002723 146.0
TLS1_k127_6071952_0 nickel-dependent hydrogenase, large subunit K06281 - 1.12.99.6 1.007e-260 813.0
TLS1_k127_6071952_1 dna ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 593.0
TLS1_k127_6071952_2 ATP dependent DNA ligase C terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005748 488.0
TLS1_k127_6071952_3 Pfam Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 331.0
TLS1_k127_6071952_4 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.0000000000000000000000000001977 120.0
TLS1_k127_6071952_5 4 iron, 4 sulfur cluster binding K00124 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0006066,GO:0006071,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016052,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0031224,GO:0031226,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:0071944,GO:1901575,GO:1901615,GO:1901616 - 0.00000000000000000000000007008 110.0
TLS1_k127_6079072_0 ABC transporter K03701 - - 0.0 1181.0
TLS1_k127_6079072_1 Bacterial membrane protein YfhO - - - 0.0000000008751 70.0
TLS1_k127_6080145_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.543e-268 846.0
TLS1_k127_6080145_1 SMART serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 322.0
TLS1_k127_6084949_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 444.0
TLS1_k127_6084949_1 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000001505 222.0
TLS1_k127_6084949_2 (EAL) domain protein - - - 0.000000000000000000000000000002013 134.0
TLS1_k127_6087092_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006301 368.0
TLS1_k127_6087092_1 4Fe-4S single cluster domain of Ferredoxin I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 366.0
TLS1_k127_6087092_2 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 302.0
TLS1_k127_6101561_0 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000003401 254.0
TLS1_k127_6101561_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003556 254.0
TLS1_k127_6101561_2 sigma factor activity K02405 - - 0.0000000000000000000000000000000803 136.0
TLS1_k127_6101561_3 Ferric uptake regulator family K09825 - - 0.0000000000000000000000000103 114.0
TLS1_k127_6101561_4 cellulose binding - - - 0.0006945 49.0
TLS1_k127_611143_0 Uncharacterized protein family (UPF0051) K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 333.0
TLS1_k127_611143_1 Cys/Met metabolism PLP-dependent enzyme K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 287.0
TLS1_k127_6112084_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 456.0
TLS1_k127_6112084_1 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008676 286.0
TLS1_k127_6112084_2 Phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000004492 177.0
TLS1_k127_6112084_3 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000002438 133.0
TLS1_k127_6112084_4 Protein of unknown function (DUF433) - - - 0.00000000000000000000004328 100.0
TLS1_k127_6112084_5 - - - - 0.00001083 51.0
TLS1_k127_6112084_6 - - - - 0.00002197 50.0
TLS1_k127_6113072_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 490.0
TLS1_k127_6113072_1 acyl-CoA dehydrogenase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 379.0
TLS1_k127_6113072_2 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 304.0
TLS1_k127_6113072_3 Ankyrin repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001013 251.0
TLS1_k127_6113072_4 Domain of unknown function (DUF4276) - - - 0.00000000000000000000001242 108.0
TLS1_k127_6113072_5 TIGRFAM YD repeat protein - - - 0.00000004397 59.0
TLS1_k127_6115796_0 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007179 348.0
TLS1_k127_6115796_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 329.0
TLS1_k127_6115796_2 dihydrofolate reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 320.0
TLS1_k127_6115796_3 COG1309 Transcriptional regulator - - - 0.00000000000000000000000000000000001852 142.0
TLS1_k127_6115796_4 Integrase core domain K07497 - - 0.000000000000000000003389 103.0
TLS1_k127_6115796_5 - - - - 0.000000000000000001051 93.0
TLS1_k127_6122091_0 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000001173 138.0
TLS1_k127_6122091_1 - - - - 0.000000001281 73.0
TLS1_k127_6135762_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 312.0
TLS1_k127_6135762_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000001249 161.0
TLS1_k127_6135762_2 Thioredoxin-like - - - 0.0000000000000000000001159 107.0
TLS1_k127_6135762_3 Uncharacterised nucleotidyltransferase - - - 0.0000000001016 70.0
TLS1_k127_6140922_0 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 527.0
TLS1_k127_6140922_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009527 397.0
TLS1_k127_6140922_2 thiolester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000406 213.0
TLS1_k127_6140922_3 transcriptional regulator K13770 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000001884 166.0
TLS1_k127_6141578_0 nodulation K00612 - - 6.551e-266 830.0
TLS1_k127_6141578_1 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000003132 198.0
TLS1_k127_6141578_2 - - - - 0.0000000000000000000000000000000005323 134.0
TLS1_k127_6141578_3 - - - - 0.00000000000005972 77.0
TLS1_k127_6141578_4 - - - - 0.0000000000003197 72.0
TLS1_k127_6149402_0 Belongs to the glycosyl hydrolase 57 family - - - 0.00000003801 58.0
TLS1_k127_6149402_1 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0001828 53.0
TLS1_k127_6162397_0 Aminotransferase class-III - - - 1.698e-213 673.0
TLS1_k127_6169266_0 PFAM CBS domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005912 404.0
TLS1_k127_6169266_1 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 391.0
TLS1_k127_6169266_10 - - - - 0.0007293 49.0
TLS1_k127_6169266_2 PFAM ABC transporter related K01990,K16907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 343.0
TLS1_k127_6169266_3 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 294.0
TLS1_k127_6169266_4 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000046 203.0
TLS1_k127_6169266_5 Transcriptional regulatory protein, C terminal K02483,K07667 GO:0008150,GO:0040007 - 0.0000000000000000000000000000000000000000000000005612 197.0
TLS1_k127_6169266_6 ATPase, P-type transporting, HAD superfamily, subfamily IC K16905 - - 0.000000000000000000000000000000000000001505 164.0
TLS1_k127_6169266_7 transmembrane transport K16906 - - 0.000000000000000000000000009076 120.0
TLS1_k127_6169266_8 Domain of unknown function (DUF4143) K07133 - - 0.0003798 44.0
TLS1_k127_6169266_9 rhs family - - - 0.0003807 53.0
TLS1_k127_6193150_0 Found in ATP-dependent protease La (LON) K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 573.0
TLS1_k127_6193150_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000008419 149.0
TLS1_k127_6195339_0 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 378.0
TLS1_k127_6195339_1 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000103 277.0
TLS1_k127_6195339_2 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion K02564 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 3.5.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000436 250.0
TLS1_k127_6195339_3 SIS domain K07106 - 4.2.1.126 0.00000000000005451 74.0
TLS1_k127_619883_0 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 534.0
TLS1_k127_619883_2 PIN domain - - - 0.000000000000000000000000000000002487 133.0
TLS1_k127_619883_3 phospholipase Carboxylesterase K06999 - - 0.00000000000000000000000001099 126.0
TLS1_k127_619883_4 positive regulation of growth - - - 0.0000000000000000001263 90.0
TLS1_k127_619883_5 - - - - 0.00000000000000003939 90.0
TLS1_k127_6212517_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 381.0
TLS1_k127_6212517_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 385.0
TLS1_k127_6216284_0 PFAM ATP-binding region, ATPase domain protein domain protein K07683 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 337.0
TLS1_k127_6216284_1 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001364 276.0
TLS1_k127_6216284_2 response regulator K02479 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002009 271.0
TLS1_k127_6216284_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003378 239.0
TLS1_k127_6216284_4 Drug exporters of the RND superfamily - - - 0.00000000000000000000000000006084 121.0
TLS1_k127_6216284_5 Beta-phosphoglucomutase family hydrolase K01087 - 3.1.3.12 0.0000000000000000000004433 104.0
TLS1_k127_6248164_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 302.0
TLS1_k127_6248164_1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000001488 160.0
TLS1_k127_6248164_2 EamA-like transporter family - - - 0.0000000000000000000000000000000003116 138.0
TLS1_k127_6248164_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - 0.00000000000001214 79.0
TLS1_k127_6248164_4 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain - - - 0.000001493 56.0
TLS1_k127_6253878_0 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 466.0
TLS1_k127_6253878_1 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007709 244.0
TLS1_k127_6253878_2 PFAM Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000000000296 210.0
TLS1_k127_6253878_4 Beta-lactamase - - - 0.0002896 45.0
TLS1_k127_6254082_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 2.976e-310 960.0
TLS1_k127_6254082_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 9.231e-310 958.0
TLS1_k127_6268932_0 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 497.0
TLS1_k127_6268932_1 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000002835 266.0
TLS1_k127_6268932_2 conserved protein UCP033924 - - - 0.000000000000000000000000000000000000003306 151.0
TLS1_k127_6268932_3 PFAM Uncharacterised protein family (UPF0227) K07000 - - 0.0000000000000006927 87.0
TLS1_k127_6269206_0 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000005938 170.0
TLS1_k127_6269206_1 CDP-alcohol phosphatidyltransferase K17884 - 2.7.8.39 0.000000000000000000006748 101.0
TLS1_k127_6269206_2 L,D-transpeptidase catalytic domain - - - 0.000000001229 68.0
TLS1_k127_6269206_3 Belongs to the thioredoxin family K03671 - - 0.0000001246 53.0
TLS1_k127_6269528_0 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 407.0
TLS1_k127_6269528_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000005485 143.0
TLS1_k127_6269528_2 - - - - 0.00000000000000000000000007056 116.0
TLS1_k127_6269528_3 - - - - 0.000000000003067 74.0
TLS1_k127_6269528_4 - - - - 0.000000000008317 72.0
TLS1_k127_6269528_5 - - - - 0.0000000001658 68.0
TLS1_k127_6269528_6 - - - - 0.00005401 46.0
TLS1_k127_6269528_7 Putative zinc-finger - - - 0.0001279 52.0
TLS1_k127_6270833_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 332.0
TLS1_k127_6270833_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000106 57.0
TLS1_k127_6274289_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 412.0
TLS1_k127_6283122_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00106,K13482 - 1.17.1.4,1.17.3.2 3.182e-290 946.0
TLS1_k127_6283122_1 Belongs to the IUNH family K01239,K01250 - 3.2.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000001634 252.0
TLS1_k127_6283122_2 PFAM Inosine uridine-preferring nucleoside hydrolase K01239,K01250 - 3.2.2.1 0.0000000000000000000000000000000000000000000763 172.0
TLS1_k127_6299477_0 POT family K03305 - - 1.601e-204 649.0
TLS1_k127_6299477_1 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 296.0
TLS1_k127_6299477_2 POT family K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001446 264.0
TLS1_k127_6316053_0 amino acid transport K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008949 499.0
TLS1_k127_6316053_1 BRO family, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 439.0
TLS1_k127_6316053_2 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000005656 185.0
TLS1_k127_6316053_3 Sel1-like repeats. K07126 - - 0.0000000000000000000000000000007277 129.0
TLS1_k127_6316053_4 4Fe-4S dicluster domain K05524 - - 0.0000000000000000000000005328 108.0
TLS1_k127_6316053_5 monooxygenase activity - - - 0.00000000000000000000008663 104.0
TLS1_k127_6316053_6 beta-lactamase activity K07126 - - 0.000000000002708 79.0
TLS1_k127_6316053_7 energy transducer activity K02487,K03832,K06596 - - 0.0000000225 67.0
TLS1_k127_6316053_8 PFAM Fibronectin type III domain - - - 0.0003744 54.0
TLS1_k127_6320720_0 Peptidase M50 - - - 0.000000000000000000000000000000000000003486 157.0
TLS1_k127_6320720_1 TIGRFAM RHS repeat-associated core - - - 0.00000006748 59.0
TLS1_k127_6322111_0 peptidase S9 prolyl oligopeptidase active site - GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042597,GO:0042802,GO:0042803,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044464,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 5.929e-309 964.0
TLS1_k127_6322111_1 catalase activity K03781 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.6 4.287e-284 876.0
TLS1_k127_6322111_10 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000001164 132.0
TLS1_k127_6322111_11 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000000000005362 110.0
TLS1_k127_6322111_12 mRNA binding - - - 0.00000000000000000000906 93.0
TLS1_k127_6322111_13 Aminoglycoside phosphotransferase - - - 0.00000000000000001621 84.0
TLS1_k127_6322111_14 Lysine exporter protein LysE YggA - - - 0.0000000000000001292 88.0
TLS1_k127_6322111_15 Domain of unknown function (DUF3817) - - - 0.00000000000000255 79.0
TLS1_k127_6322111_16 Cytochrome c554 and c-prime - - - 0.000000000000002723 84.0
TLS1_k127_6322111_17 Transcriptional regulatory protein, C terminal K07775 - - 0.00000000001059 70.0
TLS1_k127_6322111_18 iron ion homeostasis K04758 - - 0.00000001956 58.0
TLS1_k127_6322111_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.405e-216 698.0
TLS1_k127_6322111_3 Sodium Bile acid symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 472.0
TLS1_k127_6322111_4 Filamentation induced by cAMP protein fic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001241 284.0
TLS1_k127_6322111_5 4-phosphoerythronate dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000006173 237.0
TLS1_k127_6322111_6 dead DEAH box helicase K03724 - - 0.0000000000000000000000000000000000000000000000000000000000001716 226.0
TLS1_k127_6322111_7 Low molecular weight phosphatase family K03741 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 0.00000000000000000000000000000000000000000000000000001366 192.0
TLS1_k127_6322111_8 glyoxalase III activity - - - 0.0000000000000000000000000000000000000448 151.0
TLS1_k127_6322111_9 Uncharacterized conserved protein (DUF2277) - - - 0.000000000000000000000000000000000000054 144.0
TLS1_k127_6323454_0 cyclic nucleotide-binding K01420,K10914 - - 0.00000000000000000000000000000000000000000000000000000000000008773 220.0
TLS1_k127_6323454_1 Homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 0.00000000000000000000000000000000000000000000000000000000003061 218.0
TLS1_k127_6323454_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000001152 127.0
TLS1_k127_6323454_3 von Willebrand factor, type A K07114 - - 0.0001022 54.0
TLS1_k127_6325538_0 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006068 348.0
TLS1_k127_6325538_1 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 330.0
TLS1_k127_6325538_2 cheY-homologous receiver domain - - - 0.000000000000000000000000000000002402 134.0
TLS1_k127_6325538_3 Peptidylprolyl isomerase K01802,K03769 - 5.2.1.8 0.00000000000000000000136 107.0
TLS1_k127_6327817_0 S-layer domain protein - - - 0.0000002073 66.0
TLS1_k127_6342649_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 7.44e-294 925.0
TLS1_k127_6342649_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000008015 85.0
TLS1_k127_6347850_0 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 496.0
TLS1_k127_6347850_1 Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 486.0
TLS1_k127_6347850_2 - - - - 0.0000000000000000000000004721 118.0
TLS1_k127_6347850_3 transferase activity, transferring glycosyl groups - - - 0.000000000000000000418 90.0
TLS1_k127_6349021_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601,K03797 - 3.1.11.6,3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 312.0
TLS1_k127_6349021_1 PFAM ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007954 287.0
TLS1_k127_6349021_2 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007359 253.0
TLS1_k127_6354311_0 PFAM Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 409.0
TLS1_k127_6354311_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000002811 201.0
TLS1_k127_6354311_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000007466 78.0
TLS1_k127_6354311_3 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00001035 48.0
TLS1_k127_6354311_4 DinB superfamily - - - 0.00001088 55.0
TLS1_k127_6368474_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006403 404.0
TLS1_k127_6368474_1 major pilin protein fima - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003992 381.0
TLS1_k127_6368474_2 Putative zinc-binding metallo-peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 390.0
TLS1_k127_6368474_3 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 359.0
TLS1_k127_6368474_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000005565 101.0
TLS1_k127_6371531_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 351.0
TLS1_k127_6371531_1 - - - - 0.0000000000000000000000000000000001223 143.0
TLS1_k127_6376135_0 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 393.0
TLS1_k127_6376135_1 cephalosporin hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 309.0
TLS1_k127_6376135_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003134 255.0
TLS1_k127_6376135_3 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000003567 160.0
TLS1_k127_6376135_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000002273 149.0
TLS1_k127_6376135_5 COGs COG0463 Glycosyltransferase involved in cell wall biogenesis - - - 0.00000000000000000000000000000001503 139.0
TLS1_k127_6376135_6 overlaps another CDS with the same product name - - - 0.00000000000000000000001554 112.0
TLS1_k127_6381875_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 537.0
TLS1_k127_6381875_1 PFAM MOFRL domain protein K11529 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114 2.7.1.165 0.0000000000000000000000000000000000028 152.0
TLS1_k127_6381875_2 diguanylate cyclase - - - 0.000000000000000000000000000000001485 145.0
TLS1_k127_6381875_3 Rhodanese Homology Domain - - - 0.0000003612 54.0
TLS1_k127_6381875_4 COG1846 Transcriptional regulators K06075 - - 0.00001758 52.0
TLS1_k127_6381875_5 AsmA family K07290 - - 0.00009374 51.0
TLS1_k127_6387851_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006151 295.0
TLS1_k127_6387851_1 extracellular solute-binding protein, family 5 K02035,K13893 - - 0.0000000000000000000000000000000000000000000000000000000000000001865 232.0
TLS1_k127_6392002_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.000000000000000000000000000000000000000000000000000214 190.0
TLS1_k127_6392002_1 Semialdehyde dehydrogenase K00133 - 1.2.1.11 0.0000000000000000000000000000000008458 143.0
TLS1_k127_6392002_2 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000001874 71.0
TLS1_k127_6392002_3 Antitoxin component of a toxin-antitoxin (TA) module - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.0000000005121 64.0
TLS1_k127_6392002_4 Cro/C1-type HTH DNA-binding domain - - - 0.00006465 48.0
TLS1_k127_6392002_5 PIN domain - - - 0.00006468 51.0
TLS1_k127_6392002_6 Toxin SymE, type I toxin-antitoxin system - - - 0.0004488 47.0
TLS1_k127_6399356_0 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.00000000000000000000000000000000000000000000000000000001163 203.0
TLS1_k127_6399356_1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000004632 150.0
TLS1_k127_6399356_2 Mitochondrial biogenesis AIM24 - - - 0.0000000000008619 81.0
TLS1_k127_6399356_3 Mitochondrial biogenesis AIM24 - - - 0.00000000004333 76.0
TLS1_k127_6399356_4 - - - - 0.00000000007689 69.0
TLS1_k127_6399356_5 helix_turn_helix, arabinose operon control protein - - - 0.000000002072 68.0
TLS1_k127_6399356_6 metal-dependent membrane protease K07052 - - 0.0001936 52.0
TLS1_k127_6399992_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 1.348e-269 841.0
TLS1_k127_6401282_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001652 297.0
TLS1_k127_6401282_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 - - 0.000000000000000000000000000000000000000000000000000000000000000000007138 241.0
TLS1_k127_6401282_2 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000002486 208.0
TLS1_k127_6413851_0 Aminotransferase K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 417.0
TLS1_k127_6413851_1 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 355.0
TLS1_k127_6413851_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 306.0
TLS1_k127_6413851_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000001954 154.0
TLS1_k127_6413851_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.00000000000000000000002502 112.0
TLS1_k127_6413851_5 Protein of unknown function (DUF4230) - - - 0.000000000000000004492 93.0
TLS1_k127_6414565_0 arylsulfatase A - - - 0.000000000000000000000000000000000000000000000000000000000000000000001242 252.0
TLS1_k127_6414565_1 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000000001252 211.0
TLS1_k127_6414565_2 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.00000000000000000000001395 105.0
TLS1_k127_6414565_3 Biopolymer transport protein K03559,K03560 - - 0.00000000000000001008 88.0
TLS1_k127_6414565_4 TIGRFAM TonB family protein K03832 - - 0.0000000000002413 72.0
TLS1_k127_6433158_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 486.0
TLS1_k127_6433158_1 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003865 248.0
TLS1_k127_6433158_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002991 233.0
TLS1_k127_6433158_3 DinB family - - - 0.00000000000000000000000000000000000000000000000004019 194.0
TLS1_k127_6433158_4 response regulator K07712 - - 0.000000000002576 74.0
TLS1_k127_6433158_5 WD40 repeat, subgroup - - - 0.0000000001419 72.0
TLS1_k127_6433158_6 Response regulator receiver - - - 0.00000000286 66.0
TLS1_k127_6433158_7 YtxH-like protein - - - 0.0001414 46.0
TLS1_k127_6437815_0 ATP hydrolysis coupled proton transport K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002065 280.0
TLS1_k127_6437815_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000002378 166.0
TLS1_k127_6437815_2 Belongs to the V-ATPase proteolipid subunit family K02124 - - 0.0000000000000000000009754 100.0
TLS1_k127_644781_0 DNA-templated transcription, initiation - - - 0.000000000000000000000001214 111.0
TLS1_k127_6450505_0 PFAM Alcohol dehydrogenase zinc-binding domain protein K19745 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 351.0
TLS1_k127_6450505_2 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 0.000000000000000000000000000000000000000000000000000000000058 229.0
TLS1_k127_6450505_3 PFAM thioesterase superfamily K02614 - - 0.0000000000000000000000000000000000000000008985 161.0
TLS1_k127_6450505_4 YbaK prolyl-tRNA synthetase associated region - - - 0.000000000000000000000000000000000000000002629 160.0
TLS1_k127_6450505_5 AI-2E family transporter K03548 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000000000000000000000008413 132.0
TLS1_k127_6450505_6 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000002637 117.0
TLS1_k127_6450505_7 DoxX K15977 - - 0.00002466 51.0
TLS1_k127_6458717_0 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 441.0
TLS1_k127_6458717_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000002796 207.0
TLS1_k127_6479054_0 Belongs to the ABC transporter superfamily K05816,K10111,K10112 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006122 448.0
TLS1_k127_6479054_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000000000000000013 203.0
TLS1_k127_6479054_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000881 193.0
TLS1_k127_6479054_3 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000000002529 173.0
TLS1_k127_6479054_4 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000001448 156.0
TLS1_k127_6479054_5 - - - - 0.000000000000153 79.0
TLS1_k127_6479054_6 peptidyl-tyrosine sulfation - - - 0.00001974 56.0
TLS1_k127_6481030_0 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 396.0
TLS1_k127_6481030_1 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000003056 60.0
TLS1_k127_6481030_2 Beta-lactamase - - - 0.0000005464 55.0
TLS1_k127_6481470_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.513e-288 922.0
TLS1_k127_6481470_1 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000003381 183.0
TLS1_k127_6481470_2 PFAM von Willebrand factor type A - - - 0.000000000000000000002836 108.0
TLS1_k127_6500133_0 PFAM Integral membrane protein TerC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 395.0
TLS1_k127_6500133_1 Transcriptional regulator K03717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 335.0
TLS1_k127_6500133_2 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000005955 236.0
TLS1_k127_6500133_3 AI-2E family transporter - - - 0.000000000000000000000000000000000000000004123 170.0
TLS1_k127_6500133_4 Transcriptional regulator K07775 - - 0.00000000000001882 79.0
TLS1_k127_6500133_5 Patatin-like phospholipase K07001 - - 0.000000000001367 74.0
TLS1_k127_6500133_7 histidine kinase A domain protein - - - 0.00001508 53.0
TLS1_k127_6547275_0 Zinc carboxypeptidase - - - 2.936e-257 822.0
TLS1_k127_6547275_1 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 451.0
TLS1_k127_6547275_2 Methyltransferase domain K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000000000001378 255.0
TLS1_k127_6547275_3 DNA-templated transcription, initiation - - - 0.00000000000000000000000001827 116.0
TLS1_k127_6547275_4 Thioesterase superfamily K07107 - - 0.0000000000000000004173 92.0
TLS1_k127_6547275_5 Bacterial regulatory proteins, tetR family - - - 0.0000000001218 70.0
TLS1_k127_6556283_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 412.0
TLS1_k127_6556283_1 PFAM Rhomboid family protein - - - 0.00000000000000000000000000000000000000000000000000002378 197.0
TLS1_k127_6556283_2 - - - - 0.000000000000000008168 96.0
TLS1_k127_6557386_0 Putative ATP-binding cassette K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000001127 242.0
TLS1_k127_6557386_1 response to antibiotic - - - 0.00000000000000000000001788 106.0
TLS1_k127_6557386_2 Protein of unknown function (DUF2752) - - - 0.000000000000000003153 91.0
TLS1_k127_6557386_3 TM2 domain - - - 0.0000005872 55.0
TLS1_k127_6557386_4 TM2 domain - - - 0.0004889 52.0
TLS1_k127_6577095_0 ATPase involved in DNA repair - - - 6.641e-296 932.0
TLS1_k127_6581612_0 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000002435 159.0
TLS1_k127_6581612_1 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000001024 74.0
TLS1_k127_6582711_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000002693 276.0
TLS1_k127_6582711_1 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.00000000000000000000000000000000000000003289 164.0
TLS1_k127_6582711_2 isoprenoid biosynthetic process K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000004187 136.0
TLS1_k127_6582711_3 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000005728 121.0
TLS1_k127_6582711_4 - - - - 0.000000006102 62.0
TLS1_k127_6582711_5 Pfam:Methyltransf_26 - - - 0.0001283 47.0
TLS1_k127_6582711_6 - - - - 0.0001466 52.0
TLS1_k127_6589844_0 Tubulin like - - - 1.178e-210 684.0
TLS1_k127_6589844_1 von Willebrand factor (vWF) type A domain - - - 0.0000000000001182 74.0
TLS1_k127_6590750_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 416.0
TLS1_k127_6590750_1 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004353 278.0
TLS1_k127_6590750_2 D,D-heptose 1,7-bisphosphate phosphatase K02841,K02843,K02849,K03271,K03272,K03273 - 2.7.1.167,2.7.7.70,3.1.3.82,3.1.3.83,5.3.1.28 0.00000000000000000000000000000000000000000006336 174.0
TLS1_k127_6590750_3 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000001983 164.0
TLS1_k127_6590750_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. K08968 - 1.8.4.14 0.0000000000000000000000000000000000006328 159.0
TLS1_k127_6590750_5 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000000002492 135.0
TLS1_k127_6590750_6 Regulatory protein - - - 0.0000000000000000000000000665 110.0
TLS1_k127_6600615_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006808 408.0
TLS1_k127_6600615_1 ATPases associated with a variety of cellular activities K09691 - - 0.00000000000000000000000000000000000000000000000000001257 202.0
TLS1_k127_6600615_2 Transport permease protein K09690 - - 0.0000000000000000079 87.0
TLS1_k127_6600615_3 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000204 97.0
TLS1_k127_6603658_0 Transposase zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 308.0
TLS1_k127_6603658_1 Helix-hairpin-helix motif K02237 - - 0.00000000000007295 79.0
TLS1_k127_6603658_2 Periplasmic serine protease - - - 0.000000000156 69.0
TLS1_k127_6603658_3 Helix-turn-helix domain - - - 0.00000007755 59.0
TLS1_k127_6603658_4 Cupin domain - - - 0.0003034 46.0
TLS1_k127_6603658_5 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0006503 50.0
TLS1_k127_6607509_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.415e-222 707.0
TLS1_k127_6607509_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000001804 190.0
TLS1_k127_6607509_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000008295 137.0
TLS1_k127_6607509_3 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000001575 83.0
TLS1_k127_6607509_4 Pkd domain containing protein - - - 0.0007684 54.0
TLS1_k127_6619896_0 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004627 540.0
TLS1_k127_6627017_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 400.0
TLS1_k127_6627017_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 342.0
TLS1_k127_6627017_2 Transglycosylase associated protein - - - 0.00000000000000000000007884 102.0
TLS1_k127_6628735_0 Recombinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 374.0
TLS1_k127_6628735_1 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 329.0
TLS1_k127_6628735_10 Chaperone of endosialidase - - - 0.0000002891 63.0
TLS1_k127_6628735_11 - - - - 0.0001179 51.0
TLS1_k127_6628735_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000831 312.0
TLS1_k127_6628735_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000001343 182.0
TLS1_k127_6628735_4 TIGRFAM addiction module toxin, Txe YoeB family K19158 - - 0.00000000000000000000000000000000000008229 149.0
TLS1_k127_6628735_5 Antitoxin component of a toxin-antitoxin (TA) module K19159 - - 0.000000000000000000000000009989 113.0
TLS1_k127_6628735_6 involved in molybdopterin and thiamine biosynthesis family 2 K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000000001531 79.0
TLS1_k127_6628735_7 - - - - 0.00000007473 62.0
TLS1_k127_6628735_8 Helix-turn-helix domain - - - 0.0000001315 59.0
TLS1_k127_6628735_9 COG NOG22472 non supervised orthologous group - - - 0.0000001319 53.0
TLS1_k127_6645224_0 peptidase K07386 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 544.0
TLS1_k127_6645224_1 Domain of unknown function DUF11 - - - 0.00000000000000000000000000000000000000000407 175.0
TLS1_k127_6652633_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 300.0
TLS1_k127_6652633_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000001347 186.0
TLS1_k127_6652633_2 STAS domain - - - 0.000000000000000000000000000000000007972 139.0
TLS1_k127_6652633_3 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.0000000000000000000000000000000009385 139.0
TLS1_k127_6652633_4 Zn peptidase - - - 0.0000000000000000000000000000003299 136.0
TLS1_k127_6671269_0 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000004408 222.0
TLS1_k127_6671269_1 Serine/Threonine protein kinases, catalytic domain K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.0000000000000000000000000000000000000000000000002176 199.0
TLS1_k127_6671269_2 - - - - 0.000000000000000000000000005781 115.0
TLS1_k127_6671269_3 InterPro IPR007367 - - - 0.00000000000000000005997 92.0
TLS1_k127_6685092_0 Tricorn protease homolog K08676 - - 3.594e-204 661.0
TLS1_k127_6685092_1 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 337.0
TLS1_k127_6685092_2 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007931 248.0
TLS1_k127_6685092_3 Diguanylate cyclase with PAS PAC - - - 0.00000000000000000000000000000000000000000000000000000000000008359 227.0
TLS1_k127_6685092_4 Putative zinc-binding metallo-peptidase - - - 0.000000000000000000000000000000000000000000000000000143 195.0
TLS1_k127_6685092_5 Damage-inducible protein DinB - - - 0.00000000000000000000000000000000000000000000009093 180.0
TLS1_k127_6685092_6 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000001408 162.0
TLS1_k127_6685092_7 EVE domain - - - 0.0000000000000000000000000000000000000002275 160.0
TLS1_k127_6685092_8 Domain of unknown function (DUF4349) - - - 0.00000000000000000000000000000002038 138.0
TLS1_k127_6685092_9 Diguanylate cyclase - - - 0.00000000000000000000001509 113.0
TLS1_k127_6686072_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 432.0
TLS1_k127_6686072_1 Predicted membrane protein (DUF2306) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 312.0
TLS1_k127_6686072_2 - K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007898 279.0
TLS1_k127_6686072_3 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.0000000000000000000000000000000000000000000000002632 178.0
TLS1_k127_6686072_4 PFAM Glycosyl K12994 - 2.4.1.349 0.0000000000000000000000000000000000000000003968 173.0
TLS1_k127_6686072_5 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000008724 175.0
TLS1_k127_6686072_6 - - - - 0.0000000000000000000000000000000000000005363 158.0
TLS1_k127_6686072_7 - - - - 0.00002336 54.0
TLS1_k127_6690517_0 GAF domain - - - 0.00000000000000000000000000000000000000000000000001422 195.0
TLS1_k127_6690517_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000694 187.0
TLS1_k127_6690517_2 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000001148 140.0
TLS1_k127_6690517_3 - - - - 0.000000008142 63.0
TLS1_k127_6699058_0 efflux transmembrane transporter activity - - - 2.536e-202 657.0
TLS1_k127_6699058_1 acetyltransferase K22441 - 2.3.1.57 0.000000000000000000000000000000000000000000001049 171.0
TLS1_k127_6707459_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 327.0
TLS1_k127_6707459_1 Polysaccharide export protein K01991,K20988 - - 0.0000000000000000000000000000000000000000000000005253 186.0
TLS1_k127_6707459_2 Capsular polysaccharide biosynthesis protein K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000003983 168.0
TLS1_k127_6722912_0 Transposase K07491 - - 0.0000000000000000000000000000000000000000000000008785 179.0
TLS1_k127_6722912_1 SMART protein phosphatase 2C domain protein - - - 0.0000000000000000000000000000001805 138.0
TLS1_k127_6726671_0 Y_Y_Y domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 419.0
TLS1_k127_6726671_1 Dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 362.0
TLS1_k127_6726671_2 MFS_1 like family K08151,K08153 - - 0.00000000000000000000000000000000000000000000000000000000002821 223.0
TLS1_k127_6726671_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000005346 177.0
TLS1_k127_6733332_0 - - - - 0.00000000000000000000000005767 111.0
TLS1_k127_6733332_1 ISFtu1 transposase K01152 - - - 0.0000000000000002226 86.0
TLS1_k127_6733332_2 ISFtu1 transposase K01152 - - - 0.000000000000001403 87.0
TLS1_k127_674182_0 Putative zinc binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 572.0
TLS1_k127_674182_1 Belongs to the DegT DnrJ EryC1 family K02805 - 2.6.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 504.0
TLS1_k127_674182_2 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009543 458.0
TLS1_k127_674182_3 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K00067,K01790 - 1.1.1.133,5.1.3.13 0.0000000000000000000000000000000000000000000000000000000007708 216.0
TLS1_k127_674182_4 PKS_PP_betabranch - - - 0.00000000000000000000000000000000000000000000000000000001186 216.0
TLS1_k127_674182_5 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000001815 197.0
TLS1_k127_674182_6 Nucleotidyl transferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000005088 154.0
TLS1_k127_674182_7 cephalosporin hydroxylase - - - 0.000000000000006625 79.0
TLS1_k127_6750972_0 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000001177 195.0
TLS1_k127_6750972_1 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000003166 153.0
TLS1_k127_6750972_2 Domain of unknown function (DUF4214) K18827 - 2.1.1.294,2.7.1.181 0.000000000000000000000000000000005715 141.0
TLS1_k127_6750972_3 Ribosomal protein S18 K02963 - - 0.00000000000000000000000009526 110.0
TLS1_k127_6750972_4 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000001199 97.0
TLS1_k127_6752592_0 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 545.0
TLS1_k127_6752592_1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 531.0
TLS1_k127_6752592_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 304.0
TLS1_k127_6752592_3 SMART Diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001667 269.0
TLS1_k127_6752592_4 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 0.0000000000000000000000000000000000000000000000001218 179.0
TLS1_k127_6752592_5 CHAT domain - - - 0.000000000000000000000000001645 131.0
TLS1_k127_6754198_0 PFAM Pilus assembly protein PilO K02664 - - 0.0000000008418 67.0
TLS1_k127_6754198_1 Pilus assembly protein, PilP K02665 - - 0.000000005324 64.0
TLS1_k127_6754198_2 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.000008677 57.0
TLS1_k127_6759579_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000006189 235.0
TLS1_k127_6759579_1 Uncharacterised protein family (UPF0175) - - - 0.000000000000000001456 93.0
TLS1_k127_6760006_0 aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 313.0
TLS1_k127_6760006_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000001069 170.0
TLS1_k127_6760006_2 Pyridoxal-dependent decarboxylase conserved domain - - - 0.000000000000000000000000000000007095 132.0
TLS1_k127_6765482_0 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 338.0
TLS1_k127_6765482_1 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.000000000000000000000000000000000000008557 153.0
TLS1_k127_6766632_0 TonB-dependent receptor K02014,K16089 - - 2.443e-197 634.0
TLS1_k127_6766632_1 Signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 322.0
TLS1_k127_6766632_2 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002902 273.0
TLS1_k127_6766632_3 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000006457 166.0
TLS1_k127_6766632_4 Domain of unknown function (DUF4154) - - - 0.00000000000000000000000000008811 122.0
TLS1_k127_6767208_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008626 391.0
TLS1_k127_6767208_1 PFAM sigma-54 factor interaction domain-containing protein K02481,K07714,K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000000592 233.0
TLS1_k127_6767208_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.000000000000000000000000000000000007155 147.0
TLS1_k127_6767208_3 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.00000000000000000000000000000001717 127.0
TLS1_k127_6767208_4 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000001006 112.0
TLS1_k127_6767208_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000001085 117.0
TLS1_k127_6775723_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 460.0
TLS1_k127_6775723_1 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 291.0
TLS1_k127_6775723_2 PAS fold K02484 - 2.7.13.3 0.00000000000000000000003887 100.0
TLS1_k127_6778185_0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008039 302.0
TLS1_k127_6778185_1 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002876 248.0
TLS1_k127_6778185_2 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000004817 104.0
TLS1_k127_6778185_3 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.00000000000000000005551 95.0
TLS1_k127_6778185_4 AIR synthase related protein, C-terminal domain K01008 - 2.7.9.3 0.00001661 47.0
TLS1_k127_6781458_0 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 3.568e-229 730.0
TLS1_k127_6781458_1 - - - - 0.000000000000000000000000007213 114.0
TLS1_k127_6781458_2 - - - - 0.000000008964 59.0
TLS1_k127_6781458_3 - - - - 0.00000005072 57.0
TLS1_k127_6809609_0 DNA topological change K03168,K03658 - 3.6.4.12,5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 363.0
TLS1_k127_6809609_1 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000007571 237.0
TLS1_k127_6809609_2 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000005774 201.0
TLS1_k127_6809609_3 cell redox homeostasis - - - 0.000000000000000000000000000000000001381 149.0
TLS1_k127_6809609_4 HPr kinase - - - 0.000000001722 70.0
TLS1_k127_6809609_5 Ribosomal protein L11 methyltransferase (PrmA) K11434 - 2.1.1.319 0.00000819 53.0
TLS1_k127_6819206_0 Stage II sporulation protein M - - - 0.00000000000000000000000000000000000000000000001395 183.0
TLS1_k127_6819206_1 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000005154 165.0
TLS1_k127_6819206_2 RDD family - - - 0.0000000000000000000001627 112.0
TLS1_k127_6819206_3 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000005026 72.0
TLS1_k127_6819206_4 membrane protein domain - - - 0.000000002665 65.0
TLS1_k127_6819206_5 - - - - 0.00002879 53.0
TLS1_k127_6819470_0 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003082 277.0
TLS1_k127_6819470_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000001854 145.0
TLS1_k127_6819470_2 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000326 108.0
TLS1_k127_6819470_3 Belongs to the UPF0109 family K06960 - - 0.00000000000000000001438 93.0
TLS1_k127_6819470_4 Ribosomal protein S16 K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000001283 87.0
TLS1_k127_6824227_0 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 436.0
TLS1_k127_6824227_1 Replicative DNA helicase K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 422.0
TLS1_k127_6824227_2 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 350.0
TLS1_k127_6824227_3 desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003673 289.0
TLS1_k127_6824227_4 DEAD DEAH box K03724 - - 0.0000000000000000000000000000000000000000000000000000000001652 209.0
TLS1_k127_6824227_5 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000002833 195.0
TLS1_k127_6824227_6 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.00000000000000000000000000000000000000000000002036 180.0
TLS1_k127_6824227_7 Tetratricopeptide repeat - - - 0.0000000000000000000001455 106.0
TLS1_k127_6824227_8 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.000000000000003552 87.0
TLS1_k127_6825419_0 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007195 256.0
TLS1_k127_6825419_1 PFAM metallophosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001043 252.0
TLS1_k127_6825419_2 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000001534 174.0
TLS1_k127_6825419_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.000000000000000001225 98.0
TLS1_k127_6825419_4 two-component system, chemotaxis family, sensor kinase CheA with response regulator domain K02487,K06596 - - 0.00000162 55.0
TLS1_k127_6828737_0 GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 490.0
TLS1_k127_6828737_1 mechanosensitive ion channel activity K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.0000000000000000000000001716 109.0
TLS1_k127_684203_0 AAA domain (Cdc48 subfamily) K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001495 259.0
TLS1_k127_684203_1 phosphorelay signal transduction system - - - 0.000000000000000000003711 98.0
TLS1_k127_684203_2 PFAM VanZ family protein - - - 0.000001784 56.0
TLS1_k127_6844626_0 - - - - 0.000000000000000000000000000000000000000000000000000001117 203.0
TLS1_k127_6844626_1 ECF sigma factor K03088 - - 0.000000000000000000003568 98.0
TLS1_k127_6844626_2 Saccharopine dehydrogenase - - - 0.00000002444 65.0
TLS1_k127_6844626_3 - - - - 0.000000633 58.0
TLS1_k127_6848363_0 ADP binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009387 393.0
TLS1_k127_6848363_1 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000001344 199.0
TLS1_k127_6849063_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004151 518.0
TLS1_k127_6849063_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 394.0
TLS1_k127_6849063_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000168 171.0
TLS1_k127_6849620_0 Sortilin, neurotensin receptor 3, - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004877 551.0
TLS1_k127_6849620_1 - - - - 0.0000000129 64.0
TLS1_k127_6849620_2 - - - - 0.00003749 51.0
TLS1_k127_6853023_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 3.008e-315 977.0
TLS1_k127_6853023_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 1.134e-203 639.0
TLS1_k127_6853023_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000002515 180.0
TLS1_k127_6853212_0 DinB family - - - 0.0000000000000000000000000000000000000000000000002523 181.0
TLS1_k127_6853212_1 COG1393 Arsenate reductase and related proteins, glutaredoxin family K00537 - 1.20.4.1 0.000000000000000000000000000009714 128.0
TLS1_k127_6853212_3 Helix-turn-helix domain - - - 0.0000000000000000003385 94.0
TLS1_k127_6853212_4 acetyltransferase K00799 - 2.5.1.18 0.0008326 44.0
TLS1_k127_686115_0 oligopeptide transporter - - - 2.894e-239 755.0
TLS1_k127_686115_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000000000002661 132.0
TLS1_k127_6863596_0 transferase activity, transferring acyl groups K14658,K17840,K18815 - 2.3.1.59,2.3.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 580.0
TLS1_k127_686551_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 493.0
TLS1_k127_686551_1 acetyltransferase K22441 - 2.3.1.57 0.000000000000000000000000000000000000000009893 159.0
TLS1_k127_686551_2 - - - - 0.0000000000000000000000000000442 123.0
TLS1_k127_686551_3 TonB-dependent Receptor Plug Domain - - - 0.00000000000000000001515 95.0
TLS1_k127_686799_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 586.0
TLS1_k127_686799_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 427.0
TLS1_k127_686799_2 PFAM DGPFAETKE family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000001586 231.0
TLS1_k127_686799_3 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001044 224.0
TLS1_k127_6878320_0 D-arabinono-1,4-lactone oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 458.0
TLS1_k127_6878320_1 - - - - 0.000000000000000000000000000000000000000000000000221 188.0
TLS1_k127_6886106_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 374.0
TLS1_k127_6886106_1 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 354.0
TLS1_k127_6886106_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000002734 154.0
TLS1_k127_6886106_3 Rubrerythrin - - - 0.00001497 53.0
TLS1_k127_6909636_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 401.0
TLS1_k127_6909636_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 341.0
TLS1_k127_6909636_2 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001116 259.0
TLS1_k127_6909636_3 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.0000000000123 68.0
TLS1_k127_6910860_0 3-carboxyethylcatechol 2,3-dioxygenase activity K00455,K15058,K15059 - 1.13.11.15,1.13.11.74,1.13.11.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 397.0
TLS1_k127_6910860_1 Belongs to the aldehyde dehydrogenase family K00130,K00151,K10217 GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0008802,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.32,1.2.1.60,1.2.1.8,1.2.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 341.0
TLS1_k127_6910860_2 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 355.0
TLS1_k127_6910860_3 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15058 - - 0.000000000000000000000000000000000000000000000000004071 198.0
TLS1_k127_6910860_4 - - - - 0.0000000000000000000000000000000000000008356 157.0
TLS1_k127_6910860_5 23S rRNA-intervening sequence protein - - - 0.0000000000000000000004685 99.0
TLS1_k127_6910860_6 Translation initiation inhibitor, yjgF family K15067 - 3.5.99.5 0.00000000000000000134 99.0
TLS1_k127_6913663_0 Aconitase C-terminal domain K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 499.0
TLS1_k127_6913663_1 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009116 404.0
TLS1_k127_6913663_10 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000007154 62.0
TLS1_k127_6913663_2 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005725 261.0
TLS1_k127_6913663_3 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000005852 228.0
TLS1_k127_6913663_4 Pfam SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000002145 210.0
TLS1_k127_6913663_5 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000003935 198.0
TLS1_k127_6913663_6 transferase activity, transferring acyl groups - - - 0.0000000000000000000000000000000000000000000000003038 179.0
TLS1_k127_6913663_7 PIN domain - - - 0.00000000000000000000000000000000001869 139.0
TLS1_k127_6913663_8 DinB superfamily - - - 0.00000000000000000000000000000000002158 142.0
TLS1_k127_6913663_9 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000003363 91.0
TLS1_k127_6918340_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 449.0
TLS1_k127_6918340_1 CAAX amino terminal protease family K07052 - - 0.000000000000000000000000001663 123.0
TLS1_k127_6918340_2 Snare associated golgi protein - - - 0.000000000000000000003072 102.0
TLS1_k127_6929452_0 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 359.0
TLS1_k127_6929452_1 Protein of unknown function (DUF2723) - - - 0.0000000009261 72.0
TLS1_k127_6933685_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 522.0
TLS1_k127_6933685_1 Cys Met metabolism PLP-dependent enzyme K01739,K01758 - 2.5.1.48,4.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 473.0
TLS1_k127_6933685_10 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000004147 137.0
TLS1_k127_6933685_11 COG1925 Phosphotransferase system, HPr-related proteins K08485,K11189 GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 - 0.0000000000000000000005397 98.0
TLS1_k127_6933685_12 Protein of unknown function (DUF1572) - - - 0.0000000000000001351 87.0
TLS1_k127_6933685_13 cheY-homologous receiver domain - - - 0.0000000000006482 79.0
TLS1_k127_6933685_2 Permease YjgP YjgQ family protein K07091,K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 393.0
TLS1_k127_6933685_3 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 377.0
TLS1_k127_6933685_4 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576 4.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 313.0
TLS1_k127_6933685_5 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 293.0
TLS1_k127_6933685_6 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.00000000000000000000000000000000000000000000000000000000000000000000000003908 257.0
TLS1_k127_6933685_7 extracellular solute-binding protein, family 5 K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001021 265.0
TLS1_k127_6933685_8 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000006427 205.0
TLS1_k127_6933685_9 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000005068 190.0
TLS1_k127_6939690_0 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.00000000000000000000000000001685 119.0
TLS1_k127_6939690_1 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth - - - 0.000000000000000000000005857 104.0
TLS1_k127_6939690_2 Gas vesicle protein K - - - 0.00000000000000000000004486 104.0
TLS1_k127_6939690_3 Gas vesicle synthesis protein GvpL/GvpF - - - 0.0000000000000000008532 95.0
TLS1_k127_6939690_4 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000009206 73.0
TLS1_k127_6939690_5 Gas vesicle protein - - - 0.00000000004359 64.0
TLS1_k127_6939690_6 CopG antitoxin of type II toxin-antitoxin system - - - 0.000006464 51.0
TLS1_k127_6939690_7 ParE toxin of type II toxin-antitoxin system, parDE K19092 - - 0.00001672 54.0
TLS1_k127_6939690_8 - - - - 0.0005343 46.0
TLS1_k127_6941285_0 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 327.0
TLS1_k127_6941285_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001253 286.0
TLS1_k127_6941285_2 Belongs to the DapB family K00215 - 1.17.1.8 0.0007844 42.0
TLS1_k127_6950680_0 protein conserved in bacteria - - - 9.493e-200 640.0
TLS1_k127_6950680_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 462.0
TLS1_k127_6950680_2 Protein of unknown function (DUF433) - - - 0.000000000000000000003763 94.0
TLS1_k127_6950680_3 - - - - 0.00000000000001696 81.0
TLS1_k127_6954097_0 General secretory system II, protein E domain protein K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 609.0
TLS1_k127_6954097_1 SAM-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006326 303.0
TLS1_k127_6954097_3 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000001939 76.0
TLS1_k127_6955593_0 3'(2'),5'-bisphosphate nucleotidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 391.0
TLS1_k127_6955593_1 beta' subunit K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 296.0
TLS1_k127_697704_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 426.0
TLS1_k127_697704_1 Dihydrodipicolinate reductase, N-terminus K21672 - 1.4.1.12,1.4.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 304.0
TLS1_k127_697704_2 Putative serine dehydratase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004284 284.0
TLS1_k127_697704_3 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.00000000000000000000000000000000000000000000000000000000000005382 218.0
TLS1_k127_697704_4 - - - - 0.000000000000000000000000323 115.0
TLS1_k127_697704_5 Transcriptional regulatory protein, C terminal K07657,K07662 - - 0.000000000003651 72.0
TLS1_k127_697704_6 Putative addiction module component - - - 0.000173 47.0
TLS1_k127_6989695_0 protein-disulfide reductase activity K04084,K06196 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 377.0
TLS1_k127_6989695_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 313.0
TLS1_k127_6989695_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000002822 208.0
TLS1_k127_6989695_3 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000006525 164.0
TLS1_k127_6989695_4 RNA-binding protein K07574 - - 0.000000000000000000006552 96.0
TLS1_k127_6989695_5 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000221 99.0
TLS1_k127_6989695_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000001924 64.0
TLS1_k127_6999265_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 380.0
TLS1_k127_6999265_1 Leukotriene A4 hydrolase, C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 376.0
TLS1_k127_6999265_2 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000005302 194.0
TLS1_k127_6999265_3 protein homotetramerization - - - 0.0000000000000000006171 88.0
TLS1_k127_7002219_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006729 263.0
TLS1_k127_7002219_1 PhoQ Sensor - - - 0.00000000000000000000000000000406 124.0
TLS1_k127_7002219_2 Protein of unknown function (DUF433) - - - 0.000000000000000000000002748 103.0
TLS1_k127_7002219_3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) K11294 - - 0.0000000000005283 81.0
TLS1_k127_7002219_4 protein encoded in hypervariable junctions of pilus gene clusters - - - 0.0001025 46.0
TLS1_k127_7003601_0 Alpha amylase, catalytic domain K06044 - 5.4.99.15 1.387e-231 747.0
TLS1_k127_7003601_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700,K01236 - 2.4.1.18,3.2.1.141 1.402e-217 691.0
TLS1_k127_7031504_0 Dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 399.0
TLS1_k127_7031504_1 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000001423 243.0
TLS1_k127_7031504_2 hopanoid biosynthesis associated protein HpnK - - - 0.00000000000000000000000000000000000000001716 164.0
TLS1_k127_7031504_3 cyclopropane-fatty-acyl-phospholipid synthase K00568 - 2.1.1.222,2.1.1.64 0.000000000000008024 80.0
TLS1_k127_7034668_0 Pfam:DUF955 K07110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003133 509.0
TLS1_k127_7034668_1 Disulphide isomerase - - - 0.000000000000000000000000000000000000000000000000000009984 192.0
TLS1_k127_7034668_2 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000006629 187.0
TLS1_k127_7038808_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 426.0
TLS1_k127_7038808_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 420.0
TLS1_k127_7038808_2 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 396.0
TLS1_k127_7038808_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 302.0
TLS1_k127_7038808_4 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000001057 229.0
TLS1_k127_7038808_5 Cell division protein FtsQ K03589 - - 0.0000000001916 72.0
TLS1_k127_7041824_0 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 411.0
TLS1_k127_7041824_1 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 392.0
TLS1_k127_7041824_2 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004705 260.0
TLS1_k127_7061345_0 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 374.0
TLS1_k127_7061345_1 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000003536 230.0
TLS1_k127_7061345_2 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000004219 178.0
TLS1_k127_7061345_3 Receptor family ligand binding region - - - 0.0000000000000000000000000000000000000000007028 165.0
TLS1_k127_7063072_0 PFAM peptidase M1, membrane alanine aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 371.0
TLS1_k127_7063072_1 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000003017 168.0
TLS1_k127_7063072_2 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.000000000000000000000000000000000001049 142.0
TLS1_k127_7063072_3 Belongs to the ompA family - - - 0.0000000000000000000000000000001216 143.0
TLS1_k127_7063072_4 helix_turn_helix gluconate operon transcriptional repressor - - - 0.00000002577 61.0
TLS1_k127_7063072_5 helix_turn_helix gluconate operon transcriptional repressor K07978,K07979 - - 0.00001436 49.0
TLS1_k127_7063670_0 Elongator protein 3, MiaB family, Radical SAM K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 311.0
TLS1_k127_7063670_1 CarD-like/TRCF domain K07736 - - 0.00000000000000000008976 92.0
TLS1_k127_7063670_2 recombinase XerD K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.000000000612 63.0
TLS1_k127_7063717_0 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000003166 103.0
TLS1_k127_7063717_1 - - - - 0.0000000006242 67.0
TLS1_k127_7063717_2 - - - - 0.00004694 49.0
TLS1_k127_7067404_0 TonB-dependent receptor K02014 - - 6.795e-204 664.0
TLS1_k127_7067404_1 phosphodiesterase - - - 1.253e-200 651.0
TLS1_k127_7067404_2 Protein of unknown function (DUF3592) - - - 0.0000000000000000000000000000000000000000000000000000003131 211.0
TLS1_k127_7067404_3 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000001315 186.0
TLS1_k127_7067404_4 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000000000000000000004338 185.0
TLS1_k127_7067404_5 OsmC-like protein K06889,K07397 - - 0.0000000000000000000000000000000000005923 144.0
TLS1_k127_7067404_6 addiction module antidote protein HigA K21498 - - 0.000000000000000000000000000000000001962 141.0
TLS1_k127_7067404_7 RelE-like toxin of type II toxin-antitoxin system HigB - - - 0.00000000000000000000000000000000001392 137.0
TLS1_k127_7067404_8 - - - - 0.0000000000000000000000007722 118.0
TLS1_k127_7067404_9 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000002262 99.0
TLS1_k127_7073268_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 412.0
TLS1_k127_7073268_1 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000004359 181.0
TLS1_k127_7073268_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000002549 179.0
TLS1_k127_7073268_3 PFAM Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000000002684 130.0
TLS1_k127_7073268_4 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000007894 128.0
TLS1_k127_7073268_5 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000001493 91.0
TLS1_k127_7086424_0 Tryptophan halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 361.0
TLS1_k127_7086424_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 347.0
TLS1_k127_7086424_11 - - - - 0.000355 46.0
TLS1_k127_7086424_12 Transcriptional regulator - - - 0.0008791 47.0
TLS1_k127_7086424_2 PFAM IS1 transposase K07480 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001379 278.0
TLS1_k127_7086424_3 Exopolysaccharide synthesis, ExoD - - - 0.00000000000000000000000000000000000000000000000000000000000000004979 229.0
TLS1_k127_7086424_4 Nucleotidyltransferase domain K07075 - - 0.000000000000000000000000000002153 123.0
TLS1_k127_7086424_5 DNA polymerase beta domain protein region K07075 - - 0.0000000000000000000000001817 108.0
TLS1_k127_7086424_7 Protein of unknown function DUF86 - - - 0.0000000000000000000002716 100.0
TLS1_k127_7086424_8 Protein of unknown function DUF86 - - - 0.0000000000001698 76.0
TLS1_k127_7104260_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000001436 190.0
TLS1_k127_7104260_1 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0005061 44.0
TLS1_k127_7108793_0 DNA alkylation repair - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 291.0
TLS1_k127_7108793_1 Squalene--hopene cyclase - - - 0.000000000000000000000000000000000000000000000004346 176.0
TLS1_k127_7108793_2 InterPro IPR007367 - - - 0.00000000000000000000005047 103.0
TLS1_k127_7108793_3 DNA alkylation repair - - - 0.00000000002651 68.0
TLS1_k127_7111700_0 PFAM ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002711 459.0
TLS1_k127_7111700_1 Bacterial PH domain K08981 - - 0.00000000000000000000000000000000000000000000000000003179 192.0
TLS1_k127_7111700_2 Bacterial PH domain - - - 0.00000000000000000000000000000000000000000000001545 184.0
TLS1_k127_7111700_3 PFAM Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000106 146.0
TLS1_k127_7116755_0 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 332.0
TLS1_k127_7116755_1 Spore maturation protein K06373 - - 0.000000000000000000000000000000000000000000000000000000000001272 217.0
TLS1_k127_7116755_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000001419 230.0
TLS1_k127_7116755_3 Nucleoside recognition K06374 - - 0.00000000000000000000000000000000000000000000000000000000005101 209.0
TLS1_k127_7122241_0 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K21053 - 3.5.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002122 266.0
TLS1_k127_7122241_1 PRMT5 arginine-N-methyltransferase K11434 - 2.1.1.319 0.00000000000000000000000000000000000000000000000002334 193.0
TLS1_k127_7122241_2 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000001645 66.0
TLS1_k127_7144993_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005379 571.0
TLS1_k127_7144993_1 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 553.0
TLS1_k127_7144993_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 478.0
TLS1_k127_7144993_3 Belongs to the arginase family K01480 - 3.5.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 407.0
TLS1_k127_7144993_4 Belongs to the BI1 family K06890,K19416 - - 0.0000000000000000000000000000000000000000000000000000000000000000003403 237.0
TLS1_k127_7144993_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000005331 237.0
TLS1_k127_7144993_7 PFAM Cys Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.0000000000001722 70.0
TLS1_k127_7144993_8 - - - - 0.0000000001549 65.0
TLS1_k127_7144993_9 Belongs to the peptidase S8 family - - - 0.0000003094 57.0
TLS1_k127_714830_0 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 315.0
TLS1_k127_714830_1 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000005665 237.0
TLS1_k127_714830_2 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000007297 195.0
TLS1_k127_714830_3 Thioredoxin-like - - - 0.000000005667 58.0
TLS1_k127_7167665_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 299.0
TLS1_k127_7167665_1 efflux transmembrane transporter activity K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000804 268.0
TLS1_k127_7167665_2 ABC transporter, ATP-binding protein K02003 - - 0.0000000000000000000000000000000000000000000000000246 192.0
TLS1_k127_7167665_3 Helix-turn-helix XRE-family like proteins K21498 - - 0.0000000000000000000008442 98.0
TLS1_k127_7171101_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005434 462.0
TLS1_k127_7171101_1 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 325.0
TLS1_k127_7171101_2 - - - - 0.000000000000000000000000002042 121.0
TLS1_k127_7181166_0 rRNA (uridine-N3-)-methyltransferase activity K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000001123 240.0
TLS1_k127_7181166_1 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000000001175 157.0
TLS1_k127_7181166_2 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000002445 103.0
TLS1_k127_7184690_0 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 376.0
TLS1_k127_7184690_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 325.0
TLS1_k127_7184690_2 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001268 293.0
TLS1_k127_7198358_0 DNA topological change K03168 - 5.99.1.2 8.075e-238 758.0
TLS1_k127_7198358_1 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 301.0
TLS1_k127_721194_0 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 419.0
TLS1_k127_721194_1 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 355.0
TLS1_k127_721194_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 321.0
TLS1_k127_721194_3 Deoxynucleoside kinase K15518 - 2.7.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000004051 244.0
TLS1_k127_721194_4 PFAM Rhomboid family - - - 0.00000000000000000000000000000000000000000000002144 177.0
TLS1_k127_721194_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000000002729 74.0
TLS1_k127_721194_6 Putative addiction module component - - - 0.0000009226 53.0
TLS1_k127_7243234_0 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 455.0
TLS1_k127_7252390_0 DEAD DEAH box helicase K03654 - 3.6.4.12 2.133e-206 659.0
TLS1_k127_7252390_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 363.0
TLS1_k127_7252390_2 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000148 284.0
TLS1_k127_7252390_3 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000004337 177.0
TLS1_k127_7252419_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 1.811e-316 994.0
TLS1_k127_7252419_1 LysM domain M23 M37 peptidase domain protein K06194 - - 0.0000000000000001354 83.0
TLS1_k127_7253062_0 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000619 257.0
TLS1_k127_7253062_1 PFAM peptidase U61, LD-carboxypeptidase A K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000002886 208.0
TLS1_k127_7253062_2 histone H2A K63-linked ubiquitination K10914 - - 0.000000000000000000000000000000005246 142.0
TLS1_k127_7253062_3 - - - - 0.00000000004264 67.0
TLS1_k127_7253062_4 YacP-like NYN domain - - - 0.0002042 49.0
TLS1_k127_7260437_0 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 1.941e-299 940.0
TLS1_k127_7260437_1 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 383.0
TLS1_k127_7260437_2 von Willebrand factor (vWF) type A domain K11912 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 315.0
TLS1_k127_7260437_3 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002642 276.0
TLS1_k127_7260437_4 formate dehydrogenase (NAD+) activity - - - 0.000000000000000000000000000000000000000000000000000000000000000003104 230.0
TLS1_k127_7260437_5 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000002261 164.0
TLS1_k127_7260437_6 RDD family - - - 0.0001227 51.0
TLS1_k127_7266776_0 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000003876 236.0
TLS1_k127_7266776_1 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000003575 188.0
TLS1_k127_729898_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 499.0
TLS1_k127_729898_1 Pregnancy-associated plasma protein-A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 327.0
TLS1_k127_729898_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - - 0.000000000000000000000000000000000000000000000000000000000002937 228.0
TLS1_k127_729898_3 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000001886 82.0
TLS1_k127_729898_4 recA bacterial DNA recombination protein - - - 0.0000000000000009213 87.0
TLS1_k127_729898_5 Rhodanese Homology Domain K01069 - 3.1.2.6 0.00000000003682 73.0
TLS1_k127_7305912_0 alcohol dehydrogenase K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 552.0
TLS1_k127_7305912_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 434.0
TLS1_k127_7305912_2 PFAM Glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004065 275.0
TLS1_k127_7305912_3 SEC-C Motif Domain Protein - - - 0.00000000000000000000000000000000000000000000000000000000009952 230.0
TLS1_k127_7305912_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000008454 153.0
TLS1_k127_7305912_5 Family of unknown function (DUF5335) - - - 0.000164 49.0
TLS1_k127_7334484_0 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000002695 177.0
TLS1_k127_7334484_1 BsuBI/PstI restriction endonuclease C-terminus K07317 - 2.1.1.72 0.00000000000000000000000000000000000000000003261 163.0
TLS1_k127_7334484_2 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000132 157.0
TLS1_k127_7340774_0 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 289.0
TLS1_k127_7340774_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005304 250.0
TLS1_k127_7340774_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000002713 117.0
TLS1_k127_7340774_3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000008635 98.0
TLS1_k127_7340774_4 Belongs to the SecE SEC61-gamma family K03073 - - 0.0000000000000000003818 89.0
TLS1_k127_7348069_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 528.0
TLS1_k127_7348069_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000000008321 152.0
TLS1_k127_7348069_2 HEPN domain - - - 0.00000000000000000000000000000000000198 145.0
TLS1_k127_7348069_3 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000000002633 97.0
TLS1_k127_7348069_4 PFAM YcfA-like protein - - - 0.000000005217 64.0
TLS1_k127_7348069_5 - - - - 0.000000006614 59.0
TLS1_k127_7348069_6 - - - - 0.00000008848 59.0
TLS1_k127_7351532_0 phosphoserine phosphatase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000005425 207.0
TLS1_k127_7351532_1 antisigma factor binding - - - 0.00000000000000000000003391 103.0
TLS1_k127_7351532_2 sigma factor antagonist activity K04757 - 2.7.11.1 0.0000000000001512 77.0
TLS1_k127_7358742_0 ig-like, plexins, transcription factors - - - 0.00000000000000000000000000000000000000000000000000007649 214.0
TLS1_k127_7358742_1 domain protein - - - 0.000000000000000000000000000000004285 149.0
TLS1_k127_7358742_2 Planctomycete cytochrome C - - - 0.000000000000000000005383 109.0
TLS1_k127_7364346_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004313 540.0
TLS1_k127_7364346_1 O-methyltransferase activity K05303 - - 0.000000000000000000000000000000000000000000000000000000001697 218.0
TLS1_k127_7364346_2 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000003966 199.0
TLS1_k127_7364346_3 Aldolase K01625 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000232 158.0
TLS1_k127_7367627_0 ATP-dependent DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 363.0
TLS1_k127_7367627_1 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000003144 78.0
TLS1_k127_7377942_0 Oligoendopeptidase f - - - 1.373e-253 800.0
TLS1_k127_7377942_1 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000001265 175.0
TLS1_k127_7377942_2 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000095 168.0
TLS1_k127_7383803_0 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000005036 217.0
TLS1_k127_7388286_0 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 379.0
TLS1_k127_7388286_1 Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 297.0
TLS1_k127_7388286_2 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000009188 194.0
TLS1_k127_7388286_3 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000001016 188.0
TLS1_k127_7388286_4 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000000000000000000002623 175.0
TLS1_k127_7388286_5 prohibitin homologues - - - 0.00000000000000000000000000000000000000000001595 181.0
TLS1_k127_7388286_6 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000001231 157.0
TLS1_k127_7391245_0 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000002554 218.0
TLS1_k127_7391245_1 lactoylglutathione lyase activity K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000002176 168.0
TLS1_k127_7391245_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000009471 136.0
TLS1_k127_7391245_3 Bacterial membrane protein, YfhO - - - 0.00000000000004248 84.0
TLS1_k127_7391245_4 - - - - 0.000000000002415 73.0
TLS1_k127_7404545_0 Domain of unknown function (DUF4129) - - - 0.00000000000169 79.0
TLS1_k127_7417526_0 Carboxypeptidase regulatory-like domain - - - 3.074e-236 766.0
TLS1_k127_7417526_1 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000007134 247.0
TLS1_k127_7417526_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000001281 181.0
TLS1_k127_7428602_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000001663 193.0
TLS1_k127_7433143_0 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000005382 205.0
TLS1_k127_7433143_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000007887 199.0
TLS1_k127_7433143_2 Methyltransferase domain - - - 0.000000000000009447 85.0
TLS1_k127_7433143_3 Glycosyltransferase Family 4 - - - 0.00000000000001009 80.0
TLS1_k127_7434935_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 444.0
TLS1_k127_7434935_1 geranylgeranyl reductase activity - - - 0.00000000000000000000000000000000000000000000000000001193 203.0
TLS1_k127_7434935_2 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.000000000000000000000000000002337 130.0
TLS1_k127_7434935_3 Putative prokaryotic signal transducing protein - - - 0.00000000009662 70.0
TLS1_k127_7439680_0 pyrroloquinoline quinone binding K01206,K01218 - 3.2.1.51,3.2.1.78 1.503e-254 812.0
TLS1_k127_7439680_1 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000002119 227.0
TLS1_k127_7439680_2 Responsible for synthesis of pseudouridine from uracil K06177,K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23,5.4.99.28,5.4.99.29 0.000000000000000000000000000006663 126.0
TLS1_k127_7439680_3 peptidase inhibitor activity - - - 0.0000000000000000000003284 109.0
TLS1_k127_7439680_4 - - - - 0.000000000001169 75.0
TLS1_k127_7448529_0 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 438.0
TLS1_k127_7448529_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 432.0
TLS1_k127_7448529_2 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 325.0
TLS1_k127_7468372_0 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 581.0
TLS1_k127_7468372_1 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 442.0
TLS1_k127_7468372_2 Heparinase II/III N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004546 291.0
TLS1_k127_7468372_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000001253 133.0
TLS1_k127_7468372_4 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000000000000000003352 106.0
TLS1_k127_7468372_5 - - - - 0.00000000000000000000001191 111.0
TLS1_k127_746853_0 purine nucleobase transmembrane transporter activity K06901 - - 0.0000000000000000000000000000000000000000000000000000000000000000487 226.0
TLS1_k127_746853_1 - - - - 0.00000000000000000000000001744 114.0
TLS1_k127_746853_2 Tellurite resistance protein TerB - - - 0.0000000000000005139 83.0
TLS1_k127_7474492_0 Polysulphide reductase, NrfD K00185 - - 1.532e-204 647.0
TLS1_k127_7474492_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006604 387.0
TLS1_k127_7474492_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 372.0
TLS1_k127_7474492_3 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006887 317.0
TLS1_k127_7474492_4 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003844 265.0
TLS1_k127_7474492_5 Protein of unknown function (DUF3341) - - - 0.0000000000000000000000000000000000000000000000000000000000000717 217.0
TLS1_k127_7474492_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000005298 219.0
TLS1_k127_7474492_7 - - - - 0.000001031 59.0
TLS1_k127_7477658_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 389.0
TLS1_k127_7477658_1 Belongs to the CinA family K03742 - 3.5.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009659 319.0
TLS1_k127_7477658_2 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005184 288.0
TLS1_k127_7477658_3 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000008115 94.0
TLS1_k127_7477658_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000003012 79.0
TLS1_k127_7490139_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009499 548.0
TLS1_k127_7490139_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000005841 266.0
TLS1_k127_7490139_2 Phosphoesterase family K01114 - 3.1.4.3 0.00000000000000000000000000000000000000000000000000000000000000000007079 239.0
TLS1_k127_7490139_4 AAA ATPase domain - - - 0.000000000000000000828 102.0
TLS1_k127_7490139_6 Belongs to the glycosyl hydrolase 18 family - - - 0.0000161 57.0
TLS1_k127_7497120_0 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 391.0
TLS1_k127_7497120_1 GHMP kinases C terminal K07031 - 2.7.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009562 334.0
TLS1_k127_7497120_10 Nucleotidyl transferase - - - 0.0000000000000000000000000000001292 132.0
TLS1_k127_7497120_11 - - - - 0.00000000001327 78.0
TLS1_k127_7497120_12 - - - - 0.00000001214 63.0
TLS1_k127_7497120_14 Psort location CytoplasmicMembrane, score K09153 - - 0.00001999 53.0
TLS1_k127_7497120_15 - - - - 0.00002141 57.0
TLS1_k127_7497120_2 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 306.0
TLS1_k127_7497120_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 299.0
TLS1_k127_7497120_4 Transaldolase K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 289.0
TLS1_k127_7497120_5 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002335 253.0
TLS1_k127_7497120_6 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000001387 211.0
TLS1_k127_7497120_7 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.0000000000000000000000000000000000000000000000000007403 201.0
TLS1_k127_7497120_8 PFAM Methyltransferase type - - - 0.0000000000000000000000000000000000000000002056 167.0
TLS1_k127_7497120_9 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000001402 151.0
TLS1_k127_7504736_0 Domain of unknown function (DUF4214) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 317.0
TLS1_k127_7504736_1 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007043 273.0
TLS1_k127_7504736_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006071 259.0
TLS1_k127_7504736_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family - - - 0.0000000000000000000006718 111.0
TLS1_k127_7507062_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 294.0
TLS1_k127_7507062_1 Sorting nexin C terminal - - - 0.0000000000000000000000000000001893 132.0
TLS1_k127_7515043_0 TonB-dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000008278 216.0
TLS1_k127_7515043_1 Belongs to the sigma-70 factor family - - - 0.000001136 59.0
TLS1_k127_7516644_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 413.0
TLS1_k127_7516644_1 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000001305 185.0
TLS1_k127_7517783_0 AbgT putative transporter family K12942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 476.0
TLS1_k127_7517783_1 binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009939 387.0
TLS1_k127_7517783_2 ABC-type spermidine putrescine transport systems, ATPase components K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000002916 276.0
TLS1_k127_7517783_3 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000001022 161.0
TLS1_k127_7517783_4 Bacterial extracellular solute-binding protein K02012 - - 0.0001485 45.0
TLS1_k127_7526734_0 Fis Family K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 316.0
TLS1_k127_7526734_1 Domain of unknown function (DUF2520) - - - 0.00000000000000002607 91.0
TLS1_k127_7528997_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.361e-204 650.0
TLS1_k127_7528997_1 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000153 282.0
TLS1_k127_7528997_2 Leucine-rich repeat (LRR) protein - - - 0.0000000000752 68.0
TLS1_k127_7528997_3 ig-like, plexins, transcription factors - - - 0.000197 53.0
TLS1_k127_7529115_0 Dehydrogenase E1 component K00164,K01616 - 1.2.4.2,4.1.1.71 0.0 1259.0
TLS1_k127_7529115_1 Belongs to the peptidase S1B family - - - 0.000000000000000000000000000000000435 144.0
TLS1_k127_7529115_2 Phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.0000000000000000000000000001626 124.0
TLS1_k127_7529115_3 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.00000000000000000006294 94.0
TLS1_k127_7529115_4 Gcn5-related n-acetyltransferase - - - 0.000000000000000002439 96.0
TLS1_k127_7529115_5 Soluble NSF attachment protein, SNAP - - - 0.000003051 55.0
TLS1_k127_7529115_6 LytTr DNA-binding domain K02477 - - 0.00005007 50.0
TLS1_k127_7530467_0 Glutamate formimidoyltransferase K00603,K13990 - 2.1.2.5,4.3.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 531.0
TLS1_k127_7530467_1 Glutamate-1-semialdehyde aminotransferase K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 520.0
TLS1_k127_7530467_2 Bacterial sugar transferase K03606 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 379.0
TLS1_k127_7530467_3 Cell division ATP-binding protein ftsE K09811,K09812 GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531 - 0.000000000000000000000000000000000000000000000000000000000000000000000002539 251.0
TLS1_k127_7530467_4 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000000000000000001637 162.0
TLS1_k127_7542930_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 365.0
TLS1_k127_7544366_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 411.0
TLS1_k127_7544366_1 Belongs to the phosphoglycerate kinase family K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 366.0
TLS1_k127_7544366_2 PFAM Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000000000000000000002099 166.0
TLS1_k127_7544366_3 CYTH K05873 - 4.6.1.1 0.0000000000000000000000000008328 123.0
TLS1_k127_7544366_4 PhoQ Sensor - - - 0.000000000000000000001245 109.0
TLS1_k127_7561542_0 LmbE family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 502.0
TLS1_k127_7561542_2 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00007058 50.0
TLS1_k127_7586750_0 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 1.348e-274 852.0
TLS1_k127_7586750_1 acetylesterase activity - - - 0.000000000000000000000000000000000000000000000000000000000000003718 217.0
TLS1_k127_7601023_0 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000065 605.0
TLS1_k127_7601023_1 Domain of unknown function (DUF4143) K07133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 441.0
TLS1_k127_7601023_2 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 397.0
TLS1_k127_7601023_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 358.0
TLS1_k127_7601023_4 PFAM glycosyl transferase family 39 K14340 - - 0.00000000000000000000000000000000001473 154.0
TLS1_k127_7601023_5 Predicted membrane protein (DUF2142) - - - 0.0000000000000000000000000000000001746 149.0
TLS1_k127_7601023_6 PKD domain - - - 0.00000000000000000000000000006411 135.0
TLS1_k127_7605585_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000002751 211.0
TLS1_k127_7605585_1 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000005972 109.0
TLS1_k127_7605585_2 Psort location CytoplasmicMembrane, score - - - 0.00000000002219 76.0
TLS1_k127_7628073_0 - - - - 0.000000000000000000000000000000000000000000000000000009334 197.0
TLS1_k127_7628073_1 DoxX - - - 0.000000000000000000000000000000000000000000007454 169.0
TLS1_k127_7628073_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000008037 164.0
TLS1_k127_7628073_3 PFAM Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000003343 146.0
TLS1_k127_7628073_4 PFAM Endoribonuclease L-PSP - - - 0.0000007178 51.0
TLS1_k127_7628073_5 Predicted membrane protein (DUF2079) - - - 0.00003054 57.0
TLS1_k127_7666577_0 PFAM isochorismatase hydrolase - - - 0.000000000000000000000000000000000000000000000000000001057 197.0
TLS1_k127_7666577_1 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000000001001 148.0
TLS1_k127_7666577_2 PFAM secretion protein HlyD family protein K03543,K16922 - - 0.0000000000000000001556 98.0
TLS1_k127_7667958_0 PFAM Nucleotidyl transferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000007417 229.0
TLS1_k127_7667958_1 PFAM Integral membrane protein DUF92 - GO:0005575,GO:0016020 - 0.00000000000000000000000000002176 136.0
TLS1_k127_7667958_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000001738 123.0
TLS1_k127_7667958_3 Phosphoserine phosphatase - - - 0.0000000000367 76.0
TLS1_k127_7669073_0 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000002515 175.0
TLS1_k127_7669073_1 competence protein COMEC - - - 0.00000000000000000000000000000007054 130.0
TLS1_k127_7672149_0 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000003336 167.0
TLS1_k127_7672149_1 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000008479 76.0
TLS1_k127_7672149_2 - - - - 0.0000000000006524 72.0
TLS1_k127_76830_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 5.506e-226 711.0
TLS1_k127_76830_1 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 490.0
TLS1_k127_76830_10 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000388 179.0
TLS1_k127_76830_11 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000003945 154.0
TLS1_k127_76830_12 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00000000000000000001209 96.0
TLS1_k127_76830_13 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000002852 78.0
TLS1_k127_76830_2 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 306.0
TLS1_k127_76830_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004326 283.0
TLS1_k127_76830_4 Virulence protein RhuM family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006991 252.0
TLS1_k127_76830_5 Virulence protein RhuM family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001223 249.0
TLS1_k127_76830_6 Domain of unknown function (DUF4287) - - - 0.00000000000000000000000000000000000000000000000000000000000002111 219.0
TLS1_k127_76830_7 Uncharacterised nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000001173 195.0
TLS1_k127_76830_8 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K12950,K17686 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.4,3.6.3.54 0.00000000000000000000000000000000000000000000000007963 183.0
TLS1_k127_76830_9 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0000000000000000000000000000000000000000000004104 179.0
TLS1_k127_7688521_0 Oxidoreductase family, C-terminal alpha beta domain K00118,K13020 - 1.1.1.335,1.1.99.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 336.0
TLS1_k127_7688521_1 Aminoglycoside 3-N-acetyltransferase K00662 - 2.3.1.81 0.00000000000000000000000000000000000000000000000000000000004374 214.0
TLS1_k127_7688521_2 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.000000007639 64.0
TLS1_k127_7698410_0 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 404.0
TLS1_k127_7698410_1 belongs to the PRA-CH family K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000000000000004577 229.0
TLS1_k127_7698410_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000007031 126.0
TLS1_k127_7698410_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000001995 50.0
TLS1_k127_7704132_0 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008245 561.0
TLS1_k127_7704132_1 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 441.0
TLS1_k127_7704132_10 - - - - 0.0000114 52.0
TLS1_k127_7704132_2 Secretin and TonB N terminus short domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 341.0
TLS1_k127_7704132_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000009761 219.0
TLS1_k127_7704132_4 FecR protein - - - 0.000000000000000000000000000000000000004213 167.0
TLS1_k127_7704132_5 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000002745 131.0
TLS1_k127_7704132_6 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000005255 120.0
TLS1_k127_7704132_7 ig-like, plexins, transcription factors - - - 0.00000000000000000004582 106.0
TLS1_k127_7704132_8 Roadblock/LC7 domain - - - 0.000000000000001229 81.0
TLS1_k127_7704132_9 Tetratricopeptide repeat - - - 0.000000003873 68.0
TLS1_k127_7708703_0 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000001772 179.0
TLS1_k127_7708703_1 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000002996 99.0
TLS1_k127_7708703_2 PFAM Nucleotidyltransferase domain K07075 - - 0.0000000000000000001597 95.0
TLS1_k127_7714339_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 407.0
TLS1_k127_7714339_1 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000001447 141.0
TLS1_k127_7714339_2 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000001443 104.0
TLS1_k127_7714386_0 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000001028 230.0
TLS1_k127_7714386_1 Organic solvent tolerance protein K04744 - - 0.00000000000000000000000000000000000000000008085 183.0
TLS1_k127_771673_0 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004978 342.0
TLS1_k127_771673_1 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 336.0
TLS1_k127_771673_2 Ribosomal L32p protein family K02911 - - 0.00000000000000000002643 96.0
TLS1_k127_771673_3 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000003562 92.0
TLS1_k127_7718883_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 477.0
TLS1_k127_7718932_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 326.0
TLS1_k127_7718932_1 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001823 274.0
TLS1_k127_7718932_2 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001219 261.0
TLS1_k127_7718932_3 Transcriptional regulator, AbiEi antitoxin - - - 0.0000000000000000000000000000000000000000000000000000001543 200.0
TLS1_k127_7718932_4 Plasmid stabilization system - - - 0.00000003136 59.0
TLS1_k127_7723911_0 PFAM EAL domain - - - 0.0000000000000000000000000000000000000000000000003334 196.0
TLS1_k127_7723911_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000002777 119.0
TLS1_k127_7726112_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 623.0
TLS1_k127_7726112_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000857 65.0
TLS1_k127_772860_0 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 445.0
TLS1_k127_7732481_0 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 327.0
TLS1_k127_7732481_1 Pfam Glycosyl transferase family 2 K21366 - 2.4.1.122 0.00000000000000000000000000000000000000000000000000003345 203.0
TLS1_k127_7732481_3 N-terminal domain of galactosyltransferase - - - 0.00000000000000000000000000000009838 131.0
TLS1_k127_7732481_4 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000003831 128.0
TLS1_k127_7732481_5 Glycosyltransferase like family 2 - - - 0.000000000000000000002069 106.0
TLS1_k127_7732481_6 Glycosyl transferase group 1 - - - 0.0000000000000000002252 95.0
TLS1_k127_7732481_7 COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914 2.7.8.33,2.7.8.35 0.00007343 53.0
TLS1_k127_7734622_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 342.0
TLS1_k127_7734622_1 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000041 289.0
TLS1_k127_7734622_2 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001187 262.0
TLS1_k127_7734622_3 TIGRFAM maf protein K06287 - - 0.0000000000000000000000000000000000000000000000266 177.0
TLS1_k127_7746359_0 Dehydrogenase E1 component K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 465.0
TLS1_k127_7746359_1 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 360.0
TLS1_k127_7746359_2 PFAM oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 323.0
TLS1_k127_7746359_3 DNA-templated transcription, initiation K03088 - - 0.00000000000000000005165 96.0
TLS1_k127_7755640_0 Carbon starvation protein K06200 - - 9.174e-212 672.0
TLS1_k127_7755640_1 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 461.0
TLS1_k127_7755640_2 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01885,K01894 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 302.0
TLS1_k127_7755640_3 Putative lumazine-binding - - - 0.0000000000000000000000000000000000000007964 152.0
TLS1_k127_7755640_4 Protein of unknown function DUF86 - - - 0.00000000000000000000000001113 117.0
TLS1_k127_7755640_5 GCN5-related N-acetyl-transferase K06975 - - 0.0000000000000000000001398 100.0
TLS1_k127_7755640_6 Endodeoxyribonuclease RusA - - - 0.0000000000000000000004974 100.0
TLS1_k127_7756153_0 Thermolysin metallopeptidase, alpha-helical domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 369.0
TLS1_k127_7756153_1 Small Multidrug Resistance protein K11741 - - 0.000000000000000000000000000000000000004845 148.0
TLS1_k127_7756153_2 - - - - 0.000000000000000000000000000000007673 142.0
TLS1_k127_7756153_3 sequence-specific DNA binding K07729 - - 0.000000000000000006769 85.0
TLS1_k127_7767932_0 RNA methyltransferase RsmD family K08316 - 2.1.1.171 0.00000000000000000000000002027 116.0
TLS1_k127_7767932_1 phosphate starvation-inducible protein K06217 - - 0.0001254 46.0
TLS1_k127_776826_0 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 532.0
TLS1_k127_776826_1 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009155 333.0
TLS1_k127_7769510_0 Hsp70 protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 339.0
TLS1_k127_7769510_1 protein modification by small protein conjugation - - - 0.000000000000000000000000000003892 125.0
TLS1_k127_7769510_2 proteolysis K03665 - - 0.0000000000000000000003117 101.0
TLS1_k127_7769510_3 DnaJ molecular chaperone homology domain - - - 0.00000000000000000001407 107.0
TLS1_k127_7769510_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00001842 54.0
TLS1_k127_7772123_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 539.0
TLS1_k127_7772123_1 Protein of unknown function (DUF2723) - - - 0.0000000000107 78.0
TLS1_k127_7772123_2 PFAM SNARE associated Golgi protein - - - 0.0000000003632 72.0
TLS1_k127_7785149_0 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 421.0
TLS1_k127_7785149_1 Glycosyl transferase family 2 K21349 - 2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 369.0
TLS1_k127_7785149_2 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 331.0
TLS1_k127_7785149_3 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 332.0
TLS1_k127_7785149_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.000000000000000000000000000000000000000006595 171.0
TLS1_k127_7785149_5 Mannosyl-3-phosphoglycerate phosphatase family K07026 - 3.1.3.70 0.000000000000000000000000000000001959 145.0
TLS1_k127_7785149_6 transmembrane transport - - - 0.00000000000000000000000003912 122.0
TLS1_k127_7785149_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000001047 98.0
TLS1_k127_7785388_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 423.0
TLS1_k127_7785388_1 of the beta-lactamase K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000484 196.0
TLS1_k127_7785388_2 hydrolase (HAD superfamily) K07025 - - 0.00000000000000000000000000000006042 135.0
TLS1_k127_7785388_3 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000004908 107.0
TLS1_k127_7792456_0 chemotaxis protein K03406 - - 0.00000000000000000000000000000000000000000000000000000000001403 224.0
TLS1_k127_7792456_1 chemotaxis protein K03407 - 2.7.13.3 0.00000000001775 69.0
TLS1_k127_7798739_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 344.0
TLS1_k127_7798739_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 335.0
TLS1_k127_7798739_2 NAD(P)H quinone oxidoreductase, PIG3 family K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 301.0
TLS1_k127_7798739_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000006061 133.0
TLS1_k127_7798739_4 Subtilase family - - - 0.00000000000000000000000003674 116.0
TLS1_k127_7798739_5 SMART Rhodanese domain protein - - - 0.0000000000006799 78.0
TLS1_k127_7798739_6 Outer membrane protein beta-barrel domain - - - 0.00000000001599 74.0
TLS1_k127_7798739_7 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000001665 59.0
TLS1_k127_7798739_8 - - - - 0.00004019 55.0
TLS1_k127_7813181_0 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 377.0
TLS1_k127_7813181_1 Nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000002355 169.0
TLS1_k127_7813181_2 AAA domain - - - 0.0000000000000000000000000000006558 135.0
TLS1_k127_7813181_3 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000003985 113.0
TLS1_k127_783053_0 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 532.0
TLS1_k127_783053_1 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000008731 239.0
TLS1_k127_783053_2 chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000000000000000009377 224.0
TLS1_k127_783053_3 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000000000000000000000000000000000000000000003321 208.0
TLS1_k127_783053_4 Tetratricopeptide repeat - - - 0.0000000000000000169 87.0
TLS1_k127_783053_5 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104,K03325,K03741,K03892,K18701 - 1.20.4.1,2.8.4.2,3.1.3.48 0.000000000000000968 82.0
TLS1_k127_78353_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 465.0
TLS1_k127_78353_1 DNA recombination-mediator protein A K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001948 273.0
TLS1_k127_78353_2 Tetratricopeptide repeat - - - 0.0000000000001308 82.0
TLS1_k127_78353_4 topoisomerase K03168 - 5.99.1.2 0.00000001795 57.0
TLS1_k127_7839131_0 Fumarylacetoacetase N-terminal K01555 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 498.0
TLS1_k127_7844017_0 A G-specific K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000006442 238.0
TLS1_k127_785616_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 327.0
TLS1_k127_785616_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006947 299.0
TLS1_k127_785616_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009647 299.0
TLS1_k127_785616_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007109 271.0
TLS1_k127_785616_4 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000002025 236.0
TLS1_k127_7860627_0 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009012 273.0
TLS1_k127_7860627_1 YCII-related domain - - - 0.000000000000000000000000000000001485 133.0
TLS1_k127_7887429_0 Na H antiporter K05565 - - 0.000000000000000000000000000000000000000000004414 174.0
TLS1_k127_7887429_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000003057 80.0
TLS1_k127_7887429_2 BON domain - - - 0.0000000001008 68.0
TLS1_k127_7889715_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1323.0
TLS1_k127_7889715_1 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 537.0
TLS1_k127_7889715_2 HlyD family secretion protein K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006659 326.0
TLS1_k127_7889715_3 paraquat-inducible protein A K03808 - - 0.00000000000000000000000000000000000000000000000000000007613 222.0
TLS1_k127_7889715_4 Paraquat-inducible protein B K06192 - - 0.0000000000000000000000002084 114.0
TLS1_k127_7889715_5 ThiS family K03636 - - 0.0000000000003439 78.0
TLS1_k127_7890297_0 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 326.0
TLS1_k127_7890297_1 Glycosyltransferase like family 2 K16870 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576 2.4.1.289 0.0000000000000001418 92.0
TLS1_k127_7890297_2 Glycosyltransferase like family 2 - - - 0.00001102 52.0
TLS1_k127_7892632_0 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 389.0
TLS1_k127_7892632_1 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 320.0
TLS1_k127_7917951_0 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 443.0
TLS1_k127_7917951_1 Amidohydrolase family K01464 - 3.5.2.2 0.0000000000000000000000000000000000000005495 150.0
TLS1_k127_791976_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 3.001e-194 632.0
TLS1_k127_791976_1 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000001835 201.0
TLS1_k127_791976_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000985 192.0
TLS1_k127_791976_3 CGNR zinc finger - - - 0.0000000000000000000000000007777 120.0
TLS1_k127_792358_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 565.0
TLS1_k127_792358_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008555 409.0
TLS1_k127_792358_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000008454 220.0
TLS1_k127_7929632_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 539.0
TLS1_k127_7929632_1 Peptidase dimerisation domain K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004624 415.0
TLS1_k127_7929632_2 Membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.000000000000000000000000000000000000000000000000000000000000009374 232.0
TLS1_k127_7929632_3 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000001612 210.0
TLS1_k127_7929632_4 lipase activity K15349 - - 0.0000000000000000000000000000000000002332 158.0
TLS1_k127_7931200_0 Methylase involved in ubiquinone menaquinone K07755 - 2.1.1.137 5.146e-260 824.0
TLS1_k127_7931200_1 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 457.0
TLS1_k127_7931200_10 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000002278 174.0
TLS1_k127_7931200_11 PIN domain - - - 0.00000000000000000000000000000000000001927 148.0
TLS1_k127_7931200_12 transposase activity - - - 0.000000000000000000000000000006914 127.0
TLS1_k127_7931200_13 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000001225 94.0
TLS1_k127_7931200_14 Protein of unknown function (DUF1648) - - - 0.000000000000000006393 96.0
TLS1_k127_7931200_15 Redox-active disulfide protein - - - 0.00000000000000002221 89.0
TLS1_k127_7931200_16 translation initiation factor activity K06996 - - 0.00000000000000002647 87.0
TLS1_k127_7931200_17 PFAM regulatory protein GntR HTH K07979 - - 0.00000000000000005084 85.0
TLS1_k127_7931200_18 - - - - 0.0000000000000001733 88.0
TLS1_k127_7931200_19 - - - - 0.000000000000003105 77.0
TLS1_k127_7931200_2 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 355.0
TLS1_k127_7931200_20 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000001364 90.0
TLS1_k127_7931200_21 protein conserved in bacteria K09931 - - 0.000008629 56.0
TLS1_k127_7931200_3 PFAM PKD domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 361.0
TLS1_k127_7931200_4 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001407 270.0
TLS1_k127_7931200_5 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008097 264.0
TLS1_k127_7931200_6 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000001629 232.0
TLS1_k127_7931200_7 InterPro IPR007367 - - - 0.00000000000000000000000000000000000000000000000000000000007456 218.0
TLS1_k127_7931200_8 protein conserved in cyanobacteria - - - 0.0000000000000000000000000000000000000000000000000000001463 203.0
TLS1_k127_7931200_9 Oxygenase, catalysing oxidative methylation of damaged DNA - - - 0.00000000000000000000000000000000000000000000000000001901 199.0
TLS1_k127_7936321_0 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000007238 253.0
TLS1_k127_7936321_1 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000002789 241.0
TLS1_k127_7936321_10 Binds directly to 16S ribosomal RNA K02968 - - 0.00000002423 58.0
TLS1_k127_7936321_2 MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000000000000000000000009588 201.0
TLS1_k127_7936321_3 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000002046 145.0
TLS1_k127_7936321_4 PFAM OmpA MotB domain protein K03640 - - 0.0000000000000000000000000000000003243 144.0
TLS1_k127_7936321_5 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000001321 120.0
TLS1_k127_7936321_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000002377 116.0
TLS1_k127_7936321_7 - - - - 0.00000000000000000000003306 104.0
TLS1_k127_7936321_8 Response regulator receiver domain - - - 0.00000000000001281 81.0
TLS1_k127_7936321_9 TonB C terminal K03646,K03832 - - 0.0000000000001605 80.0
TLS1_k127_7941889_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 399.0
TLS1_k127_7941889_1 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 379.0
TLS1_k127_7941889_2 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002005 303.0
TLS1_k127_7941889_3 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000686 271.0
TLS1_k127_7941889_4 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000002573 216.0
TLS1_k127_7941889_5 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.0000000000000000000000741 108.0
TLS1_k127_7963766_0 pyrimidine-nucleoside phosphorylase K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000007706 264.0
TLS1_k127_7963766_1 DNA modification - - - 0.000000000000000000000000000000000000000000000000000000000000000000001377 245.0
TLS1_k127_7963766_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000005396 136.0
TLS1_k127_7990769_0 Domain of unknown function (DUF4143) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 441.0
TLS1_k127_7990769_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009075 447.0
TLS1_k127_8003507_0 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000005952 209.0
TLS1_k127_8003507_1 Protein of unknown function (DUF433) - - - 0.000000000000000000000002709 104.0
TLS1_k127_8003507_2 peroxiredoxin activity - - - 0.00000000000000005387 84.0
TLS1_k127_8003507_3 DoxX K15977 - - 0.00000000000001758 76.0
TLS1_k127_8003507_4 - - - - 0.00009831 53.0
TLS1_k127_8019649_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 1e-323 1008.0
TLS1_k127_8019649_1 Phosphomethylpyrimidine kinase K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 302.0
TLS1_k127_8019649_2 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001494 271.0
TLS1_k127_8019649_3 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000001125 247.0
TLS1_k127_8019649_4 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000000000001578 233.0
TLS1_k127_8019649_5 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000003533 183.0
TLS1_k127_8019649_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944 - 0.000000000000000000000000000000000000000004278 157.0
TLS1_k127_8019649_7 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000004731 143.0
TLS1_k127_8019649_8 antitoxin component of a - GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.00000000000000000000000000007826 117.0
TLS1_k127_8019649_9 Phosphopantetheine attachment site - - - 0.000000000004533 79.0
TLS1_k127_8029933_0 Metal binding domain of Ada K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000000000005775 191.0
TLS1_k127_8029933_1 ABC transporter K15738 - - 0.000000000000000000000000000000000003613 142.0
TLS1_k127_8029933_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000002855 111.0
TLS1_k127_8029933_3 Large extracellular alpha-helical protein K06894 - - 0.0000000000000000000004586 100.0
TLS1_k127_8029933_4 DNA-templated transcription, initiation K03088 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000828 81.0
TLS1_k127_8037889_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 384.0
TLS1_k127_8037889_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 347.0
TLS1_k127_8037889_2 PIN domain - - - 0.0000000000000000000000000000000000000000000004495 170.0
TLS1_k127_8037889_3 HicB family - - - 0.000000000000000000009167 95.0
TLS1_k127_8040184_0 B12 binding domain K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006973 454.0
TLS1_k127_8040184_1 FecR protein - - - 0.000008976 58.0
TLS1_k127_8053381_0 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000003951 154.0
TLS1_k127_8053381_1 General secretory system II protein E domain protein - - - 0.0000000000000000000000000000006329 124.0
TLS1_k127_8053381_2 NAD+ binding - - - 0.00000000000001239 87.0
TLS1_k127_8053381_3 - - - - 0.00000000001866 73.0
TLS1_k127_8062643_0 Dehydrogenase E1 component K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 531.0
TLS1_k127_8062643_1 protein histidine kinase activity - - - 0.0000000000000000000000000004288 124.0
TLS1_k127_8063896_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000547 578.0
TLS1_k127_8063896_1 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004942 551.0
TLS1_k127_8063896_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001704 372.0
TLS1_k127_8063896_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000000002271 108.0
TLS1_k127_8063896_4 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000003748 110.0
TLS1_k127_806919_0 PFAM multicopper oxidase type 2 K06324 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 424.0
TLS1_k127_806919_1 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001867 245.0
TLS1_k127_806919_2 Esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001456 254.0
TLS1_k127_806919_3 - - - - 0.0000000000000000000000000000000000000002465 161.0
TLS1_k127_806919_4 Domain of unknown function (DUF3597) - - - 0.0000000000000000000000000000002253 135.0
TLS1_k127_806919_5 Dehydrogenase K00117 - 1.1.5.2 0.0000000000000000000000000007803 119.0
TLS1_k127_806919_6 ankyrin repeat K16726 GO:0000785,GO:0001568,GO:0001654,GO:0001745,GO:0001751,GO:0001754,GO:0001817,GO:0001819,GO:0001944,GO:0001955,GO:0002376,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002831,GO:0002833,GO:0003674,GO:0003682,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0006275,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007005,GO:0007010,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007346,GO:0007399,GO:0007423,GO:0007492,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009887,GO:0009888,GO:0009889,GO:0009892,GO:0009894,GO:0009895,GO:0009966,GO:0009967,GO:0009987,GO:0010506,GO:0010507,GO:0010556,GO:0010564,GO:0010639,GO:0010646,GO:0010647,GO:0010821,GO:0010823,GO:0010927,GO:0010941,GO:0012505,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019730,GO:0019899,GO:0019900,GO:0019901,GO:0021700,GO:0022008,GO:0022607,GO:0023051,GO:0023052,GO:0023056,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030154,GO:0030182,GO:0030239,GO:0031032,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031329,GO:0031330,GO:0031347,GO:0031349,GO:0031430,GO:0031672,GO:0031674,GO:0031965,GO:0031967,GO:0031975,GO:0032101,GO:0032103,GO:0032501,GO:0032502,GO:0032989,GO:0033043,GO:0039531,GO:0039533,GO:0039535,GO:0040011,GO:0042692,GO:0042742,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043122,GO:0043123,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043292,GO:0043900,GO:0043902,GO:0044085,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0045087,GO:0045088,GO:0045089,GO:0045214,GO:0045595,GO:0045596,GO:0045787,GO:0045931,GO:0046530,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048592,GO:0048646,GO:0048699,GO:0048731,GO:0048749,GO:0048856,GO:0048869,GO:0050688,GO:0050776,GO:0050778,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051052,GO:0051093,GO:0051128,GO:0051129,GO:0051146,GO:0051147,GO:0051148,GO:0051150,GO:0051151,GO:0051171,GO:0051239,GO:0051240,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0055001,GO:0055002,GO:0060255,GO:0060361,GO:0060548,GO:0061061,GO:0065007,GO:0070925,GO:0071695,GO:0071840,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0090068,GO:0090596,GO:0097435,GO:0098542,GO:0099080,GO:0099081,GO:0099512,GO:1900087,GO:1900245,GO:1900246,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902531,GO:1902533,GO:1902806,GO:1902808,GO:1903146,GO:1903147,GO:2000045,GO:2000112 - 0.0000000000000000000001266 108.0
TLS1_k127_806919_7 Protein of unknown function (DUF2959) - - - 0.000000000000000001503 94.0
TLS1_k127_806919_8 Ankyrin repeat and SOCS K10324,K10325 GO:0000151,GO:0000209,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0007154,GO:0007165,GO:0007275,GO:0007517,GO:0007519,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009888,GO:0009987,GO:0014706,GO:0016567,GO:0019538,GO:0019941,GO:0023052,GO:0030154,GO:0030163,GO:0031461,GO:0031466,GO:0032446,GO:0032501,GO:0032502,GO:0032991,GO:0035914,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0043687,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045445,GO:0048513,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051603,GO:0051716,GO:0060537,GO:0060538,GO:0061061,GO:0065007,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1990234 - 0.000000000000003704 87.0
TLS1_k127_8075049_0 PFAM Stem cell self-renewal protein Piwi - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009792 498.0
TLS1_k127_8075049_1 SIR2-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 462.0
TLS1_k127_8075049_2 - - - - 0.0000000000000000000000000000000000000000000000001724 191.0
TLS1_k127_8075049_3 NmrA-like family - - - 0.000000000000003748 76.0
TLS1_k127_8079457_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 497.0
TLS1_k127_8079457_1 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000003648 73.0
TLS1_k127_8079457_2 oxidoreductase activity - - - 0.000001464 61.0
TLS1_k127_814093_0 Periplasmic protein TonB links inner and outer membranes - - - 0.000000000000000000000000000000000000000000000000000000000000004779 231.0
TLS1_k127_814093_1 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000001562 218.0
TLS1_k127_814093_2 ExbD TolR K03559 - - 0.000000000000000000000000000000001553 135.0
TLS1_k127_814093_3 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000001948 138.0
TLS1_k127_819413_0 PFAM Type II secretion system protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 566.0
TLS1_k127_819413_1 PFAM Peptidase M20 K01439 - 3.5.1.18 0.0000000000409 65.0
TLS1_k127_842284_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 546.0
TLS1_k127_842284_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000462 496.0
TLS1_k127_842284_2 Lipase (class 2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 372.0
TLS1_k127_842284_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000001782 245.0
TLS1_k127_842284_4 Responsible for synthesis of pseudouridine from uracil - - - 0.0000000000000000000000000000000000435 149.0
TLS1_k127_850915_0 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 442.0
TLS1_k127_850915_1 Methyltransferase domain - - - 0.0000000000000000001869 96.0
TLS1_k127_874271_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0000098,GO:0000166,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009087,GO:0009116,GO:0009119,GO:0009987,GO:0016020,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0019899,GO:0022610,GO:0030260,GO:0030312,GO:0033353,GO:0034641,GO:0035375,GO:0035635,GO:0036094,GO:0040007,GO:0042278,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044650,GO:0046085,GO:0046128,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0048037,GO:0050662,GO:0051186,GO:0051287,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0055086,GO:0070403,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901657 3.3.1.1 1.134e-215 678.0
TLS1_k127_874271_1 Sporulation and spore germination - - - 0.00000811 58.0
TLS1_k127_910992_0 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009062 314.0
TLS1_k127_910992_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000323 251.0
TLS1_k127_910992_2 Roadblock/LC7 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005522 224.0
TLS1_k127_910992_3 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0004604 43.0
TLS1_k127_928311_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000002954 262.0
TLS1_k127_928311_1 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000000000000000001502 201.0
TLS1_k127_930241_0 PFAM major facilitator superfamily MFS_1 K08162 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 355.0
TLS1_k127_930241_1 phosphorelay signal transduction system - - - 0.00000000000000000000000000009498 126.0
TLS1_k127_930241_2 metal-dependent phosphohydrolase, HD sub domain - - - 0.00000000000000000000000000235 128.0
TLS1_k127_930241_3 Protein of unknown function (DUF4013) - - - 0.00000000000000000000000005912 117.0
TLS1_k127_930241_4 PFAM Class I peptide chain release factor K15034 - - 0.0000000000000000000000004179 108.0
TLS1_k127_930241_5 Predicted membrane protein (DUF2085) - - - 0.00000000000000005189 87.0
TLS1_k127_930241_6 TonB C terminal - - - 0.00000002022 66.0
TLS1_k127_930241_7 VanZ like family - - - 0.000007901 55.0
TLS1_k127_930771_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1247.0
TLS1_k127_930771_1 Nacht domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 398.0
TLS1_k127_930771_2 Predicted membrane protein (DUF2157) - - - 0.0000000000000000000000000000000000002389 153.0
TLS1_k127_984017_0 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 527.0
TLS1_k127_984017_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000002315 205.0
TLS1_k127_984017_2 - - - - 0.000000000003263 79.0
TLS1_k127_984038_0 PFAM Enoyl-CoA hydratase isomerase K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 622.0