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Overview

ID MAG03981
Name TLS2_bin.1
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Tectomicrobia
Class Entotheonellia
Order Entotheonellales
Family Entotheonellaceae
Genus Entotheonella
Species
Assembly information
Completeness (%) 70.09
Contamination (%) 3.54
GC content (%) 57.0
N50 (bp) 6,022
Genome size (bp) 3,673,446

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3442

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1022654_0 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009684 402.0
TLS2_k127_1022654_1 ATPase activity K02013,K09817 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000007333 232.0
TLS2_k127_1022654_2 haloacid dehalogenase, type II K01560 - 3.8.1.2 0.00000000000000000001339 92.0
TLS2_k127_1046240_0 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 3.829e-213 673.0
TLS2_k127_1046240_1 acyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 484.0
TLS2_k127_1046240_2 PFAM Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 465.0
TLS2_k127_1046240_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 362.0
TLS2_k127_1046240_4 reverse transcriptase K00986 - 2.7.7.49 0.000000000000000000000000000000000000000000000000000000000000000003639 231.0
TLS2_k127_1046240_5 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000002128 193.0
TLS2_k127_1046240_6 Phosphopantetheine attachment site - - - 0.0000001356 58.0
TLS2_k127_1046240_7 n-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000004286 59.0
TLS2_k127_1053489_0 CO dehydrogenase flavoprotein domain protein K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 302.0
TLS2_k127_1053489_1 2-oxopent-4-enoate hydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000003219 246.0
TLS2_k127_1053489_2 Chitin-binding domain type 3 - - - 0.00000000000000000000000000000000000000000000000000000000009522 212.0
TLS2_k127_1053489_3 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000927 76.0
TLS2_k127_1053489_4 3-Hydroxyisobutyrate dehydrogenase K00020,K00042 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006573,GO:0006574,GO:0006807,GO:0008150,GO:0008152,GO:0008442,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.31,1.1.1.60 0.0000116 57.0
TLS2_k127_1068909_0 response regulator K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003055 424.0
TLS2_k127_1068909_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000003995 176.0
TLS2_k127_1068909_2 Histidine kinase K20973 - 2.7.13.3 0.000001769 57.0
TLS2_k127_10757_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 583.0
TLS2_k127_10757_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006681 519.0
TLS2_k127_10757_2 recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000002497 203.0
TLS2_k127_10757_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000001064 111.0
TLS2_k127_1080418_0 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 383.0
TLS2_k127_1080418_1 major facilitator superfamily K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002705 270.0
TLS2_k127_1080418_2 Transglutaminase/protease-like homologues K22452 - 2.3.2.13 0.00005135 49.0
TLS2_k127_108326_0 transport system periplasmic component K01989 - - 0.0000000000000000000000000000165 130.0
TLS2_k127_108326_1 Thioredoxin-like - - - 0.000000000000000000000000000234 121.0
TLS2_k127_108326_2 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.0000000000000000000000000002356 116.0
TLS2_k127_108326_3 PFAM Plasmid maintenance system killer K07334 - - 0.0000000000000000000000000009976 114.0
TLS2_k127_108326_4 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000001214 84.0
TLS2_k127_108326_5 Transcriptional regulatory protein, C terminal - - - 0.000000000000005172 77.0
TLS2_k127_108326_6 Transposase - - - 0.0000000000002489 71.0
TLS2_k127_108326_7 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000004342 71.0
TLS2_k127_108326_8 Redoxin - - - 0.000000003056 60.0
TLS2_k127_108326_9 Redoxin K03564 - 1.11.1.15 0.0000001494 57.0
TLS2_k127_1092179_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009586 532.0
TLS2_k127_1092179_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004273 410.0
TLS2_k127_1092179_10 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0003126 51.0
TLS2_k127_1092179_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000009345 244.0
TLS2_k127_1092179_3 - - - - 0.000000000000000000000000000000000000000000000000000000007387 209.0
TLS2_k127_1092179_4 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000000006007 184.0
TLS2_k127_1092179_5 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000006438 161.0
TLS2_k127_1092179_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000001618 140.0
TLS2_k127_1092179_7 Protein of unknown function (DUF507) K09804 - - 0.0000000000000002151 82.0
TLS2_k127_1092179_8 4Fe-4S binding domain K03616 - - 0.00000000001872 67.0
TLS2_k127_1092179_9 Protein of unknown function (DUF507) - - - 0.00000000004043 68.0
TLS2_k127_109974_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 5.4.2.2,5.4.2.8 1.024e-194 632.0
TLS2_k127_109974_1 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 505.0
TLS2_k127_109974_2 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 345.0
TLS2_k127_109974_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000001582 232.0
TLS2_k127_109974_4 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000003523 171.0
TLS2_k127_109974_5 Pentapeptide repeats (8 copies) - - - 0.0000000000000000000000000000000000000191 151.0
TLS2_k127_1101763_0 Peptidase C1-like family K01372 - 3.4.22.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 606.0
TLS2_k127_1101763_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 389.0
TLS2_k127_1101763_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000421 105.0
TLS2_k127_1101763_3 pilus assembly protein PilW - - - 0.00000018 63.0
TLS2_k127_1101763_4 type IV pilus modification protein PilV K02458,K02671 - - 0.000003178 56.0
TLS2_k127_1102532_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 575.0
TLS2_k127_1102532_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 439.0
TLS2_k127_1102532_2 Alginate lyase - - - 0.000000000000000000000000000000006251 143.0
TLS2_k127_1102532_3 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000004187 88.0
TLS2_k127_1102532_4 Sulfotransferase domain - - - 0.0000001772 54.0
TLS2_k127_1104784_0 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 577.0
TLS2_k127_1104784_1 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003766 259.0
TLS2_k127_1104784_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000008772 203.0
TLS2_k127_1104784_3 May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation K09021,K15067 - 3.5.99.5 0.0000000000000000000000481 113.0
TLS2_k127_1104784_4 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000001084 72.0
TLS2_k127_1104784_5 endoribonuclease L-PSP - - - 0.0000000000002166 82.0
TLS2_k127_1104784_6 Putative cyclase - - - 0.00003317 47.0
TLS2_k127_1109500_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 436.0
TLS2_k127_1109500_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 342.0
TLS2_k127_1109500_2 Protein synonym acyl-CoA synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002218 309.0
TLS2_k127_1109500_3 Branched-chain-amino-acid aminotransferase-like protein 3 K18482 - 4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000003664 220.0
TLS2_k127_1109500_4 Protein of unknown function (DUF4058) - - - 0.0000000000000000000000000000000000000000000000000000000002449 212.0
TLS2_k127_1119029_0 Decarboxylase involved in the decarboxylation and detoxification of phenolic derivatives under both aerobic and anaerobic conditions. It is able to catalyze the reversible decarboxylation of 4-hydroxybenzoate K01612 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 4.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 327.0
TLS2_k127_1119029_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000001265 258.0
TLS2_k127_1119029_2 Pfam:DUF556 - - - 0.0000000000000000000000000000000000000000000000000000000000000000003138 237.0
TLS2_k127_1119029_3 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000001854 219.0
TLS2_k127_1119029_4 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000000000000000000000000000000000000000000005274 198.0
TLS2_k127_1119029_5 Two component transcriptional regulator (LuxR family - - - 0.000000000000000000000000000000000000004466 158.0
TLS2_k127_1119029_6 Response regulator receiver K02479 - - 0.00000000000000000000000000000000001116 145.0
TLS2_k127_1119029_7 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000004849 111.0
TLS2_k127_1119029_8 Acyl carrier protein K02078 - - 0.00000001231 59.0
TLS2_k127_1122906_0 Hydantoinaseoxoprolinase domain protein K01469,K01473 - 3.5.2.14,3.5.2.9 2.691e-217 694.0
TLS2_k127_1122906_1 N-methylhydantoinase B acetone carboxylase alpha subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 547.0
TLS2_k127_1123537_0 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008942 433.0
TLS2_k127_1123537_1 Binding-protein-dependent transport system inner membrane component K02050,K15552,K15554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 393.0
TLS2_k127_1123537_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004333 241.0
TLS2_k127_1123537_3 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000002054 243.0
TLS2_k127_1123537_4 protein conserved in bacteria K09796 - - 0.00003995 50.0
TLS2_k127_114062_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 3.366e-267 831.0
TLS2_k127_114062_1 Peptidase, M16 K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 411.0
TLS2_k127_114062_2 Peptidase family M1 domain K08776 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002775 250.0
TLS2_k127_114062_3 Competence-damaged protein - - - 0.00000000000000000000000000000000000000000000000000006869 191.0
TLS2_k127_1143657_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 415.0
TLS2_k127_1143657_1 Belongs to the arginase family K01479,K01480 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0030145,GO:0034641,GO:0042401,GO:0043167,GO:0043169,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11,3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 402.0
TLS2_k127_1143657_2 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001094 259.0
TLS2_k127_1143657_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000001536 201.0
TLS2_k127_1143657_4 Belongs to the beta-ketoacyl-ACP synthases family K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000008142 185.0
TLS2_k127_1143657_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.00000000000000000000000000000000000000000000001727 175.0
TLS2_k127_1143657_6 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000005047 145.0
TLS2_k127_1153282_0 Belongs to the ABC transporter superfamily K02031,K02032,K13896 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 5.824e-235 756.0
TLS2_k127_1153282_1 transport system, permease component K13894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009736 530.0
TLS2_k127_1153282_2 transport system, permease component K13895 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 550.0
TLS2_k127_1153282_3 transposase activity - - - 0.00000000000000000000000000000000000005513 153.0
TLS2_k127_1153282_4 ABC-type oligopeptide transport system periplasmic component K13893 - - 0.0000000000001176 73.0
TLS2_k127_1153282_5 transposase activity - - - 0.0009181 45.0
TLS2_k127_1153286_0 Beta-ketoacyl synthase, N-terminal domain - - - 0.0 1782.0
TLS2_k127_1153286_1 PFAM short-chain dehydrogenase reductase SDR - - - 0.0 1525.0
TLS2_k127_1153286_10 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000002129 184.0
TLS2_k127_1153286_2 Amino acid adenylation domain - - - 0.0 1047.0
TLS2_k127_1153286_3 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 605.0
TLS2_k127_1153286_4 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 606.0
TLS2_k127_1153286_5 pfam abc-1 K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 504.0
TLS2_k127_1153286_6 Halogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 460.0
TLS2_k127_1153286_7 Involved in glycosylation steps downstream of mono-O- methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2- O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0009058,GO:0009247,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0020012,GO:0030682,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044464,GO:0046467,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 347.0
TLS2_k127_1153286_8 PFAM UDP-glucuronosyl UDP-glucosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 301.0
TLS2_k127_1153286_9 Belongs to the type-B carboxylesterase lipase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001368 292.0
TLS2_k127_1157863_0 Glycosyl transferase family 21 K03669 GO:0005575,GO:0016020 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003618 591.0
TLS2_k127_1157863_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 333.0
TLS2_k127_1157863_2 monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000002589 227.0
TLS2_k127_1157863_3 - - - - 0.00000000000000000001479 98.0
TLS2_k127_1158925_0 general secretion pathway protein G K02456 - - 0.00000000000000000000000000000000000000000000003785 173.0
TLS2_k127_1158925_1 general secretion pathway protein - - - 0.00000000000000005028 90.0
TLS2_k127_1158925_2 Prokaryotic N-terminal methylation motif - - - 0.00000003286 61.0
TLS2_k127_1158925_3 Type II secretion system (T2SS), protein K K02460 - - 0.00000006681 64.0
TLS2_k127_1158925_4 General secretion pathway protein K02459 - - 0.0000001179 63.0
TLS2_k127_1165656_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 606.0
TLS2_k127_1165656_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 556.0
TLS2_k127_1165656_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 447.0
TLS2_k127_1165656_3 COG1921 Selenocysteine synthase seryl-tRNASer selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001158 278.0
TLS2_k127_1165656_4 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002805 244.0
TLS2_k127_1165656_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000000483 179.0
TLS2_k127_1165656_6 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K07443 - 2.1.1.63 0.000000000000000000000000000000005083 132.0
TLS2_k127_1165656_7 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.000000000000000000000000000007885 124.0
TLS2_k127_1165656_8 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000002516 94.0
TLS2_k127_1186777_0 PFAM FAD dependent oxidoreductase K00105,K00111 - 1.1.3.21,1.1.5.3 1.784e-203 649.0
TLS2_k127_1186777_1 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 573.0
TLS2_k127_1186777_10 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000001173 174.0
TLS2_k127_1186777_11 PFAM cytochrome c, class I - - - 0.0000000000000000000000000000000000000000004793 166.0
TLS2_k127_1186777_12 - - - - 0.000000000000000000000000000000000001506 141.0
TLS2_k127_1186777_13 Single-strand binding protein family K03111 - - 0.00000000000000000000000000000000002495 139.0
TLS2_k127_1186777_14 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000001557 133.0
TLS2_k127_1186777_15 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000001616 128.0
TLS2_k127_1186777_16 - - - - 0.0000000000000000000000000008673 122.0
TLS2_k127_1186777_17 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000009548 79.0
TLS2_k127_1186777_18 DNA-templated transcription, initiation K03088,K03091 - - 0.0000000006496 68.0
TLS2_k127_1186777_19 cell redox homeostasis K02199 - - 0.000006007 51.0
TLS2_k127_1186777_2 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 465.0
TLS2_k127_1186777_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 389.0
TLS2_k127_1186777_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000001975 269.0
TLS2_k127_1186777_5 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007194 293.0
TLS2_k127_1186777_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000378 247.0
TLS2_k127_1186777_7 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000007116 237.0
TLS2_k127_1186777_8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000004198 187.0
TLS2_k127_1186777_9 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000197 190.0
TLS2_k127_1193666_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000002421 241.0
TLS2_k127_1193666_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000002507 226.0
TLS2_k127_1193666_2 Cytochrome c K00373,K00405,K17052 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016530,GO:0022607,GO:0034622,GO:0042126,GO:0042128,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0051131,GO:0065003,GO:0071704,GO:0071840,GO:0071941,GO:0140104,GO:2001057 - 0.00000000000000000000000000000000000000000000000002582 190.0
TLS2_k127_1193666_3 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000001381 134.0
TLS2_k127_1193666_4 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000008181 125.0
TLS2_k127_1193666_5 - - - - 0.000000000000000000000000014 115.0
TLS2_k127_1194813_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 487.0
TLS2_k127_1194813_1 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 355.0
TLS2_k127_1194813_2 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 355.0
TLS2_k127_1194813_3 BtpA family K06971 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 311.0
TLS2_k127_1222280_0 COG3639 ABC-type phosphate phosphonate transport system, permease component K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 504.0
TLS2_k127_1222280_1 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 286.0
TLS2_k127_1222280_2 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008619 258.0
TLS2_k127_1222280_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000002176 222.0
TLS2_k127_1222280_4 COG3638 ABC-type phosphate phosphonate transport system, ATPase component K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000009996 193.0
TLS2_k127_1222280_5 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000001784 131.0
TLS2_k127_1231849_0 Monomeric isocitrate dehydrogenase K00031 - 1.1.1.42 0.0 1077.0
TLS2_k127_1231849_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.506e-233 739.0
TLS2_k127_1231849_2 Polyprenyl synthetase K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 339.0
TLS2_k127_1231849_3 PFAM ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000001333 265.0
TLS2_k127_1231849_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.000003462 50.0
TLS2_k127_1232193_0 Domain of unknown function DUF87 K06915 - - 2.238e-224 707.0
TLS2_k127_1232193_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 538.0
TLS2_k127_1232193_10 - - - - 0.0000000000000000000000000000000000000000003078 164.0
TLS2_k127_1232193_11 Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization K03610 - - 0.000000000000000000000000000000000004727 145.0
TLS2_k127_1232193_12 COG0433 Predicted ATPase K06915 - - 0.00000000000000000000000000000000003308 154.0
TLS2_k127_1232193_13 Protein of unknown function (DUF1318) - - - 0.00000000000000000000000000000000005743 141.0
TLS2_k127_1232193_14 crossover junction endodeoxyribonuclease activity K01160 - 3.1.22.4 0.00000000000000000000000000000008518 132.0
TLS2_k127_1232193_15 MraZ protein, putative antitoxin-like K03925 - - 0.0000000000000000000000000003854 119.0
TLS2_k127_1232193_16 Protein conserved in bacteria - - - 0.00002678 49.0
TLS2_k127_1232193_17 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell K03608 - - 0.0000551 49.0
TLS2_k127_1232193_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 487.0
TLS2_k127_1232193_3 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 503.0
TLS2_k127_1232193_4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007585 421.0
TLS2_k127_1232193_5 VirC1 protein K03609 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 347.0
TLS2_k127_1232193_6 NurA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008898 349.0
TLS2_k127_1232193_7 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 338.0
TLS2_k127_1232193_8 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000002274 221.0
TLS2_k127_1232193_9 COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000001546 199.0
TLS2_k127_1235668_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000005659 196.0
TLS2_k127_1235668_1 PFAM major facilitator superfamily MFS_1 - - - 0.0000004049 60.0
TLS2_k127_1235668_2 amine dehydrogenase activity K08884 - 2.7.11.1 0.000703 42.0
TLS2_k127_1237431_0 beta-lactamase K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 367.0
TLS2_k127_1237431_1 COG4206 Outer membrane cobalamin receptor protein K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000796 363.0
TLS2_k127_1237431_2 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000246 145.0
TLS2_k127_1237431_3 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000002148 137.0
TLS2_k127_1247484_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 5.522e-200 644.0
TLS2_k127_1247484_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000001875 118.0
TLS2_k127_1247484_2 PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000007481 113.0
TLS2_k127_1256329_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 6.804e-229 728.0
TLS2_k127_1256329_1 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 534.0
TLS2_k127_1256329_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 422.0
TLS2_k127_1256329_3 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 413.0
TLS2_k127_1256329_4 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000001795 108.0
TLS2_k127_1261748_0 electron transfer flavoprotein K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000001768 250.0
TLS2_k127_1261748_1 electron transfer flavoprotein K03521 - - 0.00000000000000000000000000000000000000000000000000000000562 208.0
TLS2_k127_1261748_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000006522 179.0
TLS2_k127_1261748_3 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000007661 115.0
TLS2_k127_1261748_4 hydrolase or acyltransferase of alpha beta superfamily - - - 0.00000000008065 72.0
TLS2_k127_1268390_0 Animal haem peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 318.0
TLS2_k127_1268390_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000006774 210.0
TLS2_k127_1268390_2 Animal haem peroxidase - - - 0.000000000000003766 78.0
TLS2_k127_1268390_3 Lactonase, 7-bladed beta-propeller - - - 0.00004836 53.0
TLS2_k127_1285101_0 protoporphyrinogen oxidase activity K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005125 439.0
TLS2_k127_1285101_1 PFAM glycosyl transferase group 1 K15521 - 2.4.1.250 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 377.0
TLS2_k127_1285101_2 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 352.0
TLS2_k127_1285101_3 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000002355 241.0
TLS2_k127_1285101_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000004668 114.0
TLS2_k127_1285101_5 biopolymer transport protein K03559 - - 0.000003426 52.0
TLS2_k127_1313455_0 ATPase associated with various cellular activities AAA_5 K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004603 364.0
TLS2_k127_1313455_1 Glycosyl transferase family 2 K09931 - - 0.00000000000000000000000000000000000000000000000000000000000007763 220.0
TLS2_k127_1313455_2 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000005109 213.0
TLS2_k127_1313455_3 Protein of unknown function (DUF2889) K07053 - 3.1.3.97 0.00000000000000000000000000000000000007524 152.0
TLS2_k127_1313455_4 Von Willebrand factor type A K02448 - - 0.0000000005357 72.0
TLS2_k127_1322591_0 iron ABC transporter permease K02011 - - 5.206e-203 649.0
TLS2_k127_1322591_1 CbbQ/NirQ/NorQ C-terminal K04748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 338.0
TLS2_k127_1322591_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001587 282.0
TLS2_k127_1322591_3 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000001945 199.0
TLS2_k127_1322591_4 nUDIX hydrolase K01515 - 3.6.1.13 0.0000000000000001392 87.0
TLS2_k127_1322591_5 Luciferase-like monooxygenase - - - 0.000000000000000461 84.0
TLS2_k127_1324367_0 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 311.0
TLS2_k127_1324367_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 306.0
TLS2_k127_1324367_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000002769 225.0
TLS2_k127_1324367_3 Peptidase M1 membrane alanine aminopeptidase - - - 0.000007924 51.0
TLS2_k127_1324423_0 Belongs to the pyruvate kinase family K00873 GO:0001871,GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0030246,GO:0030247,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:2001065 2.7.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 378.0
TLS2_k127_1324423_1 Heat shock protein HtpX K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009322 332.0
TLS2_k127_1324423_10 Aerotolerance regulator BatC - - - 0.0000004227 59.0
TLS2_k127_1324423_11 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000397 49.0
TLS2_k127_1324423_2 ATPase associated with various cellular K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009161 318.0
TLS2_k127_1324423_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000001613 245.0
TLS2_k127_1324423_4 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000001148 150.0
TLS2_k127_1324423_5 Thiamine pyrophosphate enzyme, central domain - - - 0.0000000000000000000000000000000007828 135.0
TLS2_k127_1324423_6 BatB protein K07114 - - 0.0000000000000000000000000003152 128.0
TLS2_k127_1324423_7 oxidoreductase activity K07114 - - 0.00000000000000000000002631 111.0
TLS2_k127_1324423_8 PFAM ROSMUCR transcriptional regulator - - - 0.00000000000003508 81.0
TLS2_k127_1324423_9 Ureidoglycolate hydrolase - - - 0.0000000000001536 76.0
TLS2_k127_1328593_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 4.174e-226 715.0
TLS2_k127_1328593_1 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000001047 225.0
TLS2_k127_1334532_0 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 357.0
TLS2_k127_1334532_1 NhaP-type Na H and K H - - - 0.0000000000000000000000000000000000000001485 157.0
TLS2_k127_1338376_0 PFAM tRNA synthetase class II (D K and N) K01893 - 6.1.1.22 2.518e-208 655.0
TLS2_k127_1338376_1 PFAM ROK family protein K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000003226 211.0
TLS2_k127_1338376_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K22446 - - 0.00000000000000000000000000000000000000000001861 169.0
TLS2_k127_1356506_0 3-isopropylmalate dehydratase activity K01681,K01703,K17749,K20452 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0030312,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.3,4.2.1.33,4.2.1.35,4.2.1.85 1.251e-233 728.0
TLS2_k127_1356506_1 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.000000000000000000000000000000000000000000000000000000000000000000000000000003765 275.0
TLS2_k127_1356506_2 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000004906 256.0
TLS2_k127_1356506_3 - - - - 0.00000000000000000000000000000000000000000000000006973 184.0
TLS2_k127_1356506_4 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 GO:0001505,GO:0003674,GO:0003824,GO:0005575,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008812,GO:0009058,GO:0009628,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019285,GO:0019695,GO:0031455,GO:0031456,GO:0034641,GO:0042133,GO:0042398,GO:0044237,GO:0044249,GO:0044271,GO:0050896,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 1.1.99.1 0.0000000000000000000003605 98.0
TLS2_k127_1356506_5 Histidine kinase - - - 0.0000000000000009893 78.0
TLS2_k127_1361045_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 1.321e-258 820.0
TLS2_k127_1361045_1 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000000000000000000322 166.0
TLS2_k127_1361045_2 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000000000000000000001296 155.0
TLS2_k127_1361045_3 Haloacid dehalogenase, type II K01560 - 3.8.1.2 0.000000000000000000005042 94.0
TLS2_k127_1363254_0 Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004133 287.0
TLS2_k127_1363254_1 Ndr family K00433,K01055 - 1.11.1.10,3.1.1.24 0.00000000000000000000000000000000000000000000000000004925 198.0
TLS2_k127_1363254_2 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000001073 139.0
TLS2_k127_1363254_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000001459 74.0
TLS2_k127_1363254_4 polyhydroxyalkanoic acid synthase, PhaR subunit - - - 0.00001841 53.0
TLS2_k127_1370798_0 Proto-chlorophyllide reductase 57 kD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 419.0
TLS2_k127_1370798_1 PFAM N-6 DNA methylase K03427,K07317 - 2.1.1.72 0.000000000000000000000001154 112.0
TLS2_k127_1386042_0 Histidyl-tRNA synthetase K00765,K01892,K02502 - 2.4.2.17,6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002866 276.0
TLS2_k127_1386042_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000002128 131.0
TLS2_k127_1386042_2 Acylphosphatase K01512 - 3.6.1.7 0.0000000000000000000000001953 112.0
TLS2_k127_1398513_0 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 509.0
TLS2_k127_1427084_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 572.0
TLS2_k127_1427084_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005492 493.0
TLS2_k127_1427084_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000003435 208.0
TLS2_k127_1434078_0 inositol 2-dehydrogenase activity K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007171 373.0
TLS2_k127_1434078_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000149 280.0
TLS2_k127_1434078_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000002709 242.0
TLS2_k127_1434078_3 Protein of unknown function (DUF1009) K09949 - - 0.000000000000000000000000000000000000000000000000000000000000004371 226.0
TLS2_k127_1434078_4 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000001773 166.0
TLS2_k127_1436353_0 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 321.0
TLS2_k127_1436353_1 acetylesterase activity K01046 - 3.1.1.3 0.0000000006385 63.0
TLS2_k127_1436353_2 OsmC-like protein - - - 0.000000146 55.0
TLS2_k127_1455559_0 Belongs to the TPP enzyme family K00156 - 1.2.5.1 1.171e-278 868.0
TLS2_k127_1455559_1 (ABC) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 411.0
TLS2_k127_1455559_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006781 406.0
TLS2_k127_1455559_3 DNA-binding protein with PD1-like DNA-binding motif K06934 - - 0.00000000000000000000000000000000000000000000000002485 184.0
TLS2_k127_1455559_4 - - - - 0.000000000000000000000000000000000000000002223 162.0
TLS2_k127_1455559_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000005133 121.0
TLS2_k127_1455559_6 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.0000000000000000001643 97.0
TLS2_k127_1455559_7 peptidase M48, Ste24p - - - 0.00000000001245 66.0
TLS2_k127_1456989_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000003545 228.0
TLS2_k127_1456989_1 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000006475 161.0
TLS2_k127_1464269_0 PFAM gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 563.0
TLS2_k127_1464269_1 TIGRFAM hopanoid biosynthesis associated radical SAM protein HpnH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 494.0
TLS2_k127_1464269_10 lactate metabolic process - - - 0.0000000000000000000000000000001888 131.0
TLS2_k127_1464269_11 Putative restriction endonuclease - - - 0.000000000000000000000000003456 118.0
TLS2_k127_1464269_12 ECF sigma factor K03088 - - 0.000000000000000000000000003956 119.0
TLS2_k127_1464269_13 regulation of translation K03530,K05788 - - 0.0000000000000000000000006366 108.0
TLS2_k127_1464269_14 Phosphoribosyl-ATP pyrophosphohydrolase K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.00000000000000000006187 91.0
TLS2_k127_1464269_15 toluene tolerance K07323 - - 0.0000000001166 72.0
TLS2_k127_1464269_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 376.0
TLS2_k127_1464269_3 PFAM Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 370.0
TLS2_k127_1464269_4 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 363.0
TLS2_k127_1464269_5 phosphorelay sensor kinase activity K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 338.0
TLS2_k127_1464269_6 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.00000000000000000000000000000000000000000000000000000000000000000003133 243.0
TLS2_k127_1464269_7 ChrA protein K07240 - - 0.0000000000000000000000000000000000000000000000000000000002 206.0
TLS2_k127_1464269_8 TIGRFAM MazG family protein K02428,K02499 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000001145 199.0
TLS2_k127_1464269_9 PFAM Glyoxalase bleomycin resistance protein dioxygenase - GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 - 0.00000000000000000000000000000000000003135 148.0
TLS2_k127_146510_0 addiction module antidote protein, HigA family K21498 GO:0008150,GO:0009636,GO:0042221,GO:0050896 - 0.00000000000000000000000000001141 121.0
TLS2_k127_146510_1 Plasmid maintenance system killer K07334 - - 0.0000000000000000000000002149 107.0
TLS2_k127_146510_2 transposition, DNA-mediated K02529,K20971 - - 0.0000000000000000000001364 102.0
TLS2_k127_146510_3 PFAM Transposase IS66 family - - - 0.0000000000000000000747 95.0
TLS2_k127_146510_4 IS1 transposase K07480 - - 0.000000000000000001767 86.0
TLS2_k127_146510_5 PFAM Insertion element protein - - - 0.0000000000000004003 79.0
TLS2_k127_1487661_0 Phosphate acyltransferases K05939 - 2.3.1.40,6.2.1.20 8.199e-260 827.0
TLS2_k127_1487661_1 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 339.0
TLS2_k127_1487661_2 GlcNAc-PI de-N-acetylase K18455 GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657 3.5.1.115 0.0000000000000000000000000000000000000000000003165 173.0
TLS2_k127_1487661_3 3'-5' exonuclease activity K03547 - - 0.000000000000000000000000000000000000000000001842 174.0
TLS2_k127_1487661_4 PFAM Smr protein MutS2 - - - 0.000000000000000000000000000000000000001148 157.0
TLS2_k127_1487661_5 membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000201 151.0
TLS2_k127_1487661_6 N-terminal half of MaoC dehydratase - - - 0.0000000005541 68.0
TLS2_k127_1492418_0 ribonuclease II K01147 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 410.0
TLS2_k127_1492418_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004791 272.0
TLS2_k127_1492418_2 Oxidoreductase molybdopterin binding domain - - - 0.000000000000000000000000000000000001948 145.0
TLS2_k127_1492418_3 DSBA-like thioredoxin domain - - - 0.00000000000706 73.0
TLS2_k127_1508964_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.439e-195 627.0
TLS2_k127_1508964_1 FAD dependent oxidoreductase K15736 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 573.0
TLS2_k127_1508964_10 sequence-specific DNA binding - - - 0.0004307 52.0
TLS2_k127_1508964_2 Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine K05830 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009912 466.0
TLS2_k127_1508964_3 Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde K05829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008017 458.0
TLS2_k127_1508964_4 PFAM ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp K05827 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 395.0
TLS2_k127_1508964_5 Belongs to the acetylglutamate kinase family. LysZ subfamily K05828 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 324.0
TLS2_k127_1508964_6 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000006033 171.0
TLS2_k127_1508964_7 TIGRFAM lysine biosynthesis protein LysW K05826 - - 0.0000000000004013 72.0
TLS2_k127_1508964_8 Transcriptional regulator - - - 0.000000000001185 80.0
TLS2_k127_1508964_9 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - 0.000000004827 65.0
TLS2_k127_1521450_0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 302.0
TLS2_k127_1521450_1 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000001002 235.0
TLS2_k127_1521450_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000139 230.0
TLS2_k127_1521450_3 glycosyl transferase family 8 - - - 0.0000000000000000000000000000000000000000000000000000000001591 214.0
TLS2_k127_1521450_4 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000002031 184.0
TLS2_k127_1521450_5 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000000000000298 170.0
TLS2_k127_1524468_0 HAD-hyrolase-like K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000001373 207.0
TLS2_k127_1524468_1 PFAM Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000004328 186.0
TLS2_k127_1524468_2 - - - - 0.00000000000000000007928 98.0
TLS2_k127_1531894_0 Domain of unknown function (DUF1731) K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 344.0
TLS2_k127_1531894_1 Phosphomethylpyrimidine kinase K00868 - 2.7.1.35 0.00000000000000000000000000000000000000001732 163.0
TLS2_k127_1531894_2 sirohydrochlorin cobaltochelatase activity - - - 0.00000000000000000000000000000000000000007696 159.0
TLS2_k127_1531894_3 Type II secretory pathway, component ExeA - - - 0.000000000000000002208 94.0
TLS2_k127_1531894_4 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000003488 55.0
TLS2_k127_1553042_0 Amidohydrolase family K01465 GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006162 587.0
TLS2_k127_1553042_1 fatty acid alpha-oxidation K12261 GO:0001561,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015031,GO:0015833,GO:0016042,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0019395,GO:0019752,GO:0019842,GO:0022607,GO:0030258,GO:0030976,GO:0031907,GO:0031974,GO:0032787,GO:0033036,GO:0033365,GO:0034440,GO:0034613,GO:0036094,GO:0042579,GO:0042802,GO:0042886,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046907,GO:0048037,GO:0050662,GO:0051179,GO:0051234,GO:0051259,GO:0051641,GO:0051649,GO:0055114,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072329,GO:0072594,GO:0072662,GO:0072663,GO:0097159,GO:1901363,GO:1901575,GO:1901681 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 545.0
TLS2_k127_1553042_2 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 484.0
TLS2_k127_1553042_3 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 375.0
TLS2_k127_1553042_4 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000641 280.0
TLS2_k127_1553042_5 VanZ like family - - - 0.000003041 56.0
TLS2_k127_1569695_0 Alkaline phosphatase K01113 - 3.1.3.1 2.091e-240 753.0
TLS2_k127_1569695_1 Bacterial protein of unknown function (DUF839) K07093 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005452 468.0
TLS2_k127_1569695_2 Acetamidase/Formamidase family K01426 - 3.5.1.4 0.00000000002473 69.0
TLS2_k127_158612_0 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008231 397.0
TLS2_k127_158612_1 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009752 392.0
TLS2_k127_158612_2 COG1398 Fatty-acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000827 271.0
TLS2_k127_158612_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001617 256.0
TLS2_k127_158612_4 Pentapeptide repeat protein K18555 - - 0.0000000000000000000000000000000000000000000001649 178.0
TLS2_k127_158612_5 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000003627 146.0
TLS2_k127_158612_6 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000000001634 113.0
TLS2_k127_158612_7 PFAM RNP-1 like RNA-binding protein - - - 0.000000000000000000000000003218 114.0
TLS2_k127_158612_8 Universal stress protein - - - 0.00000000000000000000008569 104.0
TLS2_k127_1590598_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 606.0
TLS2_k127_1590598_1 amino acid - - - 0.000000000000000000000008691 111.0
TLS2_k127_1590598_2 - - - - 0.00004623 53.0
TLS2_k127_1590598_3 - - - - 0.0005068 49.0
TLS2_k127_1598708_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006968 275.0
TLS2_k127_1598708_1 Cytochrome c K07245,K14166 - - 0.000000000000000000000000000000000000000000000000000000004354 214.0
TLS2_k127_1598708_2 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000000000001249 172.0
TLS2_k127_1601013_0 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 331.0
TLS2_k127_1601013_1 Adenylate and Guanylate cyclase catalytic domain - - - 0.00001476 48.0
TLS2_k127_1606886_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 587.0
TLS2_k127_1606886_1 Major facilitator superfamily - - - 0.00000000000000000000000000000000002959 138.0
TLS2_k127_1606886_2 Alpha beta hydrolase - - - 0.0000000000000000000004398 113.0
TLS2_k127_1613964_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 3.993e-218 691.0
TLS2_k127_1613964_1 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002609 304.0
TLS2_k127_1613964_2 Binds to RNA in loop regions with AU-rich sequences K22469 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.000000004794 64.0
TLS2_k127_1613964_3 Rieske [2Fe-2S] domain - - - 0.00000002854 62.0
TLS2_k127_1625694_0 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006401 355.0
TLS2_k127_1625694_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 326.0
TLS2_k127_1625694_10 Belongs to the bacterial solute-binding protein 9 family K09815,K15727 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000002927 69.0
TLS2_k127_1625694_11 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.0000007465 57.0
TLS2_k127_1625694_2 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 293.0
TLS2_k127_1625694_3 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001907 284.0
TLS2_k127_1625694_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000791 271.0
TLS2_k127_1625694_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000002691 179.0
TLS2_k127_1625694_6 PIN domain - - - 0.000000000000000000000000000000005479 132.0
TLS2_k127_1625694_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000003662 107.0
TLS2_k127_1625694_8 Extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000008603 100.0
TLS2_k127_1625694_9 - - - - 0.00000000000008382 76.0
TLS2_k127_1629423_0 PFAM ABC transporter related K15738 - - 6.85e-210 668.0
TLS2_k127_1629423_1 Major Facilitator Superfamily K03446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007794 328.0
TLS2_k127_1629423_2 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000007761 245.0
TLS2_k127_1629423_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K00087 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000006548 225.0
TLS2_k127_1649235_0 Transposase Tn5 dimerisation domain - - - 0.000000000000000000000000000000000001661 143.0
TLS2_k127_1679707_0 FAD-dependent dehydrogenase K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 597.0
TLS2_k127_1679707_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 514.0
TLS2_k127_1679707_2 Uncharacterized conserved protein (DUF2196) - - - 0.00000000000000000000006918 102.0
TLS2_k127_1679707_3 Alpha/beta hydrolase family - - - 0.00000000000000000001221 94.0
TLS2_k127_1679707_4 - - - - 0.000004904 51.0
TLS2_k127_1703009_0 Di-haem cytochrome c peroxidase K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000009815 229.0
TLS2_k127_1703009_1 ABC 3 transport family K09816 - - 0.00000000000000000000000000000000000000000001334 172.0
TLS2_k127_1703009_2 COG1121 ABC-type Mn Zn transport systems ATPase component K02074 - - 0.00000000000000000000000000000000000000001581 162.0
TLS2_k127_1703009_3 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.00000000000000000000000000000000000002114 156.0
TLS2_k127_1703009_4 Belongs to the Fur family K03711 - - 0.000005238 51.0
TLS2_k127_17034_0 TIGRFAM Outer membrane protein K13735,K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 377.0
TLS2_k127_1703553_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019464,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045250,GO:0045252,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0097159,GO:0106077,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 8.383e-201 635.0
TLS2_k127_1703553_1 S-acyltransferase activity K00627 GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 401.0
TLS2_k127_1703553_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000002198 209.0
TLS2_k127_1703553_3 DoxX - - - 0.0000003262 52.0
TLS2_k127_172453_0 Multicopper oxidase K22348 - 1.16.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 577.0
TLS2_k127_172453_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 338.0
TLS2_k127_172453_4 Copper resistance protein D K07245 - - 0.0009159 48.0
TLS2_k127_1740345_0 formaldehyde dehydrogenase K00153 - 1.1.1.306 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 572.0
TLS2_k127_1740345_1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008518 523.0
TLS2_k127_1740345_10 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672 - 1.21.4.2 0.00000000000000000006869 92.0
TLS2_k127_1740345_11 Alpha beta hydrolase - - - 0.000000000000000009738 89.0
TLS2_k127_1740345_12 Glycine reductase complex selenoprotein A K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.00000001339 56.0
TLS2_k127_1740345_2 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 370.0
TLS2_k127_1740345_3 Glycine reductase complex component B subunit gamma K10672 - 1.21.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 329.0
TLS2_k127_1740345_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006131 312.0
TLS2_k127_1740345_5 protein conserved in cyanobacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004124 244.0
TLS2_k127_1740345_6 PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits K10671 - 1.21.4.2 0.00000000000000000000000000000000000000000000000000000000000001238 232.0
TLS2_k127_1740345_7 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000001627 205.0
TLS2_k127_1740345_8 PFAM MaoC domain protein dehydratase - - - 0.00000000000000000000000000002418 122.0
TLS2_k127_1740345_9 In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination K10670 - 1.21.4.2,1.21.4.3,1.21.4.4 0.0000000000000000000000000003894 116.0
TLS2_k127_17437_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 342.0
TLS2_k127_17437_1 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 341.0
TLS2_k127_17437_2 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000001165 213.0
TLS2_k127_17437_3 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000005006 215.0
TLS2_k127_17437_4 MlaC protein K07323 - - 0.0000000000000000000000000001407 123.0
TLS2_k127_17437_5 Protein of unknown function VcgC/VcgE (DUF2780) - - - 0.0000000000000000000000004762 112.0
TLS2_k127_17437_6 photosynthesis K12132,K20543 - 2.7.11.1 0.0000000000000000000004438 101.0
TLS2_k127_1747055_0 ThiF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 380.0
TLS2_k127_1747055_1 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009997 282.0
TLS2_k127_1747055_2 Ferric uptake regulator family K03711 - - 0.00000000000000000000000000000000000000000000000005239 181.0
TLS2_k127_1747055_3 Involved in molybdopterin and thiamine biosynthesis, family 2 K03148,K21029,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.00000000000000000000000000000000002224 136.0
TLS2_k127_1761207_0 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483,K21726 - 1.14.13.166,1.14.13.29,1.14.14.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005774 486.0
TLS2_k127_1761207_1 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 409.0
TLS2_k127_1761207_10 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00798 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000001269 201.0
TLS2_k127_1761207_11 CYTH domain K05873 - 4.6.1.1 0.0000000000000000000000000000000000008877 148.0
TLS2_k127_1761207_12 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000121 144.0
TLS2_k127_1761207_13 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000002659 136.0
TLS2_k127_1761207_14 PFAM UspA domain protein - - - 0.0000000000000000004468 92.0
TLS2_k127_1761207_2 prohibitin homologues K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 306.0
TLS2_k127_1761207_3 prohibitin homologues K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 297.0
TLS2_k127_1761207_4 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000199 285.0
TLS2_k127_1761207_5 COGs COG2912 conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003279 249.0
TLS2_k127_1761207_6 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000002618 247.0
TLS2_k127_1761207_7 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000009368 206.0
TLS2_k127_1761207_8 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000000000000000000001963 201.0
TLS2_k127_1761207_9 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249 - 1.3.8.1,1.3.8.7 0.00000000000000000000000000000000000000000000000000000007195 213.0
TLS2_k127_1770680_0 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 383.0
TLS2_k127_1770680_1 drug resistance transporter, EmrB QacA subfamily K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 342.0
TLS2_k127_1770680_2 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 297.0
TLS2_k127_1770680_3 - - - - 0.000000000000000000000000000000000000000001609 162.0
TLS2_k127_1770680_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000001484 155.0
TLS2_k127_1770680_5 Belongs to the small heat shock protein (HSP20) family - - - 0.00000000000000000000002233 104.0
TLS2_k127_1785481_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000001938 221.0
TLS2_k127_1785481_1 CDP-alcohol phosphatidyltransferase - - - 0.00000000000000000000000000000000001875 151.0
TLS2_k127_1785481_2 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000002006 87.0
TLS2_k127_1795134_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 4.147e-196 629.0
TLS2_k127_1795134_1 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 438.0
TLS2_k127_1795134_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005223 298.0
TLS2_k127_1795134_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002816 250.0
TLS2_k127_1795134_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000007734 92.0
TLS2_k127_1795134_5 Amidohydrolase family - - - 0.00000000000000002977 87.0
TLS2_k127_1807792_0 GAF domain K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 364.0
TLS2_k127_1807792_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 313.0
TLS2_k127_1807792_2 Putative modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002415 254.0
TLS2_k127_1807792_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000000000000000000000000007216 175.0
TLS2_k127_1807792_4 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 2.1.1.63 0.0000000000000000000000000000009147 124.0
TLS2_k127_1807792_5 PFAM transposase, IS4 family protein - - - 0.00000000000002143 80.0
TLS2_k127_1807792_6 Luciferase-like monooxygenase - - - 0.0000000007017 65.0
TLS2_k127_1807792_7 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00002547 53.0
TLS2_k127_1807792_8 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.00006729 48.0
TLS2_k127_1817571_0 Fumarate reductase flavoprotein C-term K00394 - 1.8.99.2 5.476e-316 973.0
TLS2_k127_1817571_1 E-Z type HEAT repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 305.0
TLS2_k127_1817571_2 cytochrome - - - 0.000000000000000000000000000000000000000000000000000000003774 207.0
TLS2_k127_1817571_3 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000007192 150.0
TLS2_k127_1817571_4 Copper chaperone PCu(A)C K09796 - - 0.000000000004646 68.0
TLS2_k127_1861186_0 Putative S-adenosyl-L-methionine-dependent methyltransferase K00574,K18164 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 338.0
TLS2_k127_1861186_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 328.0
TLS2_k127_1861186_2 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003613 286.0
TLS2_k127_1861186_3 - - - - 0.000000000000000000000000000000000000000000000000000000003881 212.0
TLS2_k127_1861186_4 Membrane fusogenic activity K09806 - - 0.000000000000000000000000000124 119.0
TLS2_k127_1863614_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 412.0
TLS2_k127_1863614_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919,K16924 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000000003955 207.0
TLS2_k127_1863614_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000003353 60.0
TLS2_k127_1884070_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.993e-249 775.0
TLS2_k127_1884070_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008958 394.0
TLS2_k127_1884070_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 392.0
TLS2_k127_1884070_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.00000000000000000000000000000000001156 147.0
TLS2_k127_1897399_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1188.0
TLS2_k127_1897399_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 6.013e-211 672.0
TLS2_k127_1897399_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:2001065 6.1.1.16,6.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 571.0
TLS2_k127_1897399_3 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 558.0
TLS2_k127_1897399_4 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 541.0
TLS2_k127_1897399_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 332.0
TLS2_k127_1897399_6 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 296.0
TLS2_k127_1897399_7 phosphoglycerate mutase K15634 - 5.4.2.12 0.0000000000000000000000000000000001588 142.0
TLS2_k127_1898219_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.093e-263 821.0
TLS2_k127_1898219_1 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 436.0
TLS2_k127_1898219_2 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 353.0
TLS2_k127_1898219_3 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000002701 202.0
TLS2_k127_1898990_0 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 295.0
TLS2_k127_1898990_1 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006027 281.0
TLS2_k127_1898990_2 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000002383 206.0
TLS2_k127_1898990_3 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000007261 190.0
TLS2_k127_1898990_4 NHL repeat - - - 0.00000000000000000000000000000000000000000000000003691 192.0
TLS2_k127_1898990_5 GNaT family - - - 0.0000000000000000000000000001858 123.0
TLS2_k127_1898990_6 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000433 107.0
TLS2_k127_1901889_0 Putative modulator of DNA gyrase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009974 613.0
TLS2_k127_1901889_1 Amidohydrolase family K15358 - 3.5.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007192 597.0
TLS2_k127_1901889_2 Zn-dependent - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 513.0
TLS2_k127_1911348_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00836 - 2.6.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 577.0
TLS2_k127_1911348_1 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008796 378.0
TLS2_k127_1911348_2 Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant K06720 - 4.2.1.108 0.000000000000000000000000000000000000000000000000000003236 194.0
TLS2_k127_1911348_3 L-2,4-diaminobutyric acid acetyltransferase K06718 - 2.3.1.178 0.000000000000000000000000000000000000000000000001533 179.0
TLS2_k127_1911348_4 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.000001686 51.0
TLS2_k127_1925186_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.415e-274 865.0
TLS2_k127_1925186_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002356 449.0
TLS2_k127_1925186_2 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008011 358.0
TLS2_k127_1925186_3 Transglycosylase SLT domain K08309 - - 0.00000847 58.0
TLS2_k127_1930516_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 590.0
TLS2_k127_1930516_1 PhoD-like phosphatase K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000008763 233.0
TLS2_k127_1930516_2 Stage V sporulation protein R K06415 - - 0.000000000000000000000000000000000000000000000663 173.0
TLS2_k127_1930921_0 rRNA (adenine-N6,N6-)-dimethyltransferase activity K00561,K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.184 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 315.0
TLS2_k127_1930921_1 methyltransferase K00559 - 2.1.1.41 0.000000000000000000000000000000000000004679 153.0
TLS2_k127_1947118_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 1.451e-270 847.0
TLS2_k127_1947118_1 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000001246 247.0
TLS2_k127_1947118_2 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000001354 170.0
TLS2_k127_1947118_3 metallopeptidase activity K06402 - - 0.000000000000000000000000000000000000000009126 161.0
TLS2_k127_1947118_4 YsiA-like protein, C-terminal region - - - 0.000000000000000000000000000000000001012 146.0
TLS2_k127_1947118_5 - - - - 0.0000000000000000000000000000001552 129.0
TLS2_k127_1947118_6 ROS/MUCR transcriptional regulator protein - - - 0.000000000000002502 78.0
TLS2_k127_1968224_0 PFAM Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 564.0
TLS2_k127_1968224_1 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 315.0
TLS2_k127_1968224_2 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000001797 214.0
TLS2_k127_1976569_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 605.0
TLS2_k127_1976569_1 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 413.0
TLS2_k127_1976569_2 PFAM Bacterial extracellular solute-binding proteins, family 3 K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 346.0
TLS2_k127_1976569_3 Exodeoxyribonuclease iii K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 305.0
TLS2_k127_1976569_4 Small-conductance mechanosensitive channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002168 300.0
TLS2_k127_1976569_5 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002243 269.0
TLS2_k127_1976569_6 phosphate ion binding K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004109 268.0
TLS2_k127_1976569_7 - - - - 0.000003911 50.0
TLS2_k127_1976866_0 General secretory system II protein E domain protein - - - 5.729e-242 770.0
TLS2_k127_1976866_1 AMP-binding enzyme C-terminal domain K00666 - - 2.478e-241 757.0
TLS2_k127_1976866_2 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06132 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 452.0
TLS2_k127_1976866_3 May be involved in recombinational repair of damaged DNA K03631,K13582 GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000004437 245.0
TLS2_k127_1976866_4 PFAM MltA K08304 - - 0.00000000000000000000000006594 114.0
TLS2_k127_1976866_5 META domain - - - 0.0000000000000000000009725 99.0
TLS2_k127_1976866_6 Peptidase dimerisation domain K01451 - 3.5.1.32 0.000002566 51.0
TLS2_k127_197699_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 397.0
TLS2_k127_197699_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000444 338.0
TLS2_k127_197699_2 integral membrane protein TIGR02587 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 299.0
TLS2_k127_197699_3 Belongs to the DapA family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000713 263.0
TLS2_k127_197699_4 urea ABC transporter, urea binding protein K11959 - - 0.00000000000000000000000000000000000000000000000000000000000000006085 225.0
TLS2_k127_197699_5 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000000000000000001861 124.0
TLS2_k127_197699_6 metallopeptidase activity K03592 - - 0.00000000000000001074 84.0
TLS2_k127_1979913_0 metalloendopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002645 290.0
TLS2_k127_1979913_1 - - - - 0.00000000000000000000000000000000000000000000000001721 185.0
TLS2_k127_1979913_2 DNA catabolic process, exonucleolytic - - - 0.000000000000000000000000000000000000000000000004722 179.0
TLS2_k127_1979913_3 retrograde transport, endosome to Golgi K07095 - - 0.0000000000000000000000000000001117 131.0
TLS2_k127_1979913_4 Pentapeptide repeats (9 copies) - - - 0.000000000000000005051 90.0
TLS2_k127_1979913_5 Short C-terminal domain - - - 0.00002887 56.0
TLS2_k127_1981669_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 603.0
TLS2_k127_1981669_1 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 372.0
TLS2_k127_1981669_2 imidazoleglycerol-phosphate synthase activity K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 349.0
TLS2_k127_1981669_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 345.0
TLS2_k127_1981669_4 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000001128 218.0
TLS2_k127_1981669_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000003044 216.0
TLS2_k127_1981669_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000006141 157.0
TLS2_k127_1982693_0 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000001027 151.0
TLS2_k127_1982693_1 - - - - 0.00000000000000001003 95.0
TLS2_k127_1982693_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000004533 87.0
TLS2_k127_1983413_0 each copy contains a frameshift at the sequence CCCCCCTTTTT and 7 copies of repeat with repeat unit SCEEP - - - 0.000000000000000000000000000000000000000000779 162.0
TLS2_k127_1983413_1 Helix-turn-helix of DDE superfamily endonuclease - - - 0.00000000003558 72.0
TLS2_k127_1983413_2 adenylylsulfate kinase activity K00860,K00958,K22424 - 2.7.1.25,2.7.3.13,2.7.7.4 0.0000000002353 61.0
TLS2_k127_1983413_3 IS1 transposase - - - 0.0002263 45.0
TLS2_k127_1985209_0 aerobic electron transport chain K00425,K08738 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 547.0
TLS2_k127_1985209_1 PFAM GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000001359 256.0
TLS2_k127_1985209_2 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000000000000005742 141.0
TLS2_k127_1985209_3 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000000000000000000000000007054 130.0
TLS2_k127_1997861_0 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 332.0
TLS2_k127_1997861_1 Protein of unknown function (DUF533) - - - 0.00000000000000000000000000000000000000000001472 171.0
TLS2_k127_1997861_2 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.000000000000000001351 86.0
TLS2_k127_1997861_3 PAS sensor protein - - - 0.000000000000002635 77.0
TLS2_k127_1997861_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0030312,GO:0031323,GO:0044464,GO:0050789,GO:0050794,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090 - 0.0000478 49.0
TLS2_k127_2005755_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 531.0
TLS2_k127_2005755_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 490.0
TLS2_k127_2005755_10 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00004194 54.0
TLS2_k127_2005755_11 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00004207 51.0
TLS2_k127_2005755_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 436.0
TLS2_k127_2005755_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 423.0
TLS2_k127_2005755_4 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000001716 249.0
TLS2_k127_2005755_5 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000001553 175.0
TLS2_k127_2005755_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000002995 98.0
TLS2_k127_2005755_7 COG0457 FOG TPR repeat - - - 0.000000000000000000001582 109.0
TLS2_k127_2005755_8 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000003074 95.0
TLS2_k127_2005755_9 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00000001169 62.0
TLS2_k127_2011489_0 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000000000000000000000000000000000000000000000000000001592 222.0
TLS2_k127_2011489_1 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000000000000000000000000000001143 188.0
TLS2_k127_2011489_2 Thioredoxin-like - - - 0.000000000000000000000000002957 117.0
TLS2_k127_2011489_3 - - - - 0.00000000000002182 79.0
TLS2_k127_2011489_5 Zinc ribbon domain - - - 0.000008518 51.0
TLS2_k127_2014535_0 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 542.0
TLS2_k127_2014535_1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008601 499.0
TLS2_k127_2014535_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007344 494.0
TLS2_k127_2014535_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 436.0
TLS2_k127_2014535_4 branched-chain amino acid K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 417.0
TLS2_k127_2014535_5 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 370.0
TLS2_k127_2020785_0 belongs to the thioredoxin family K03671,K05838 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 462.0
TLS2_k127_2020785_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009387 263.0
TLS2_k127_2020785_2 doubled CXXCH - - - 0.0000002649 64.0
TLS2_k127_2020785_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000009026 49.0
TLS2_k127_202525_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 416.0
TLS2_k127_202525_1 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000128 288.0
TLS2_k127_202525_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000002196 220.0
TLS2_k127_202525_3 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000002327 200.0
TLS2_k127_202525_4 Protein of unknown function (DUF3565) - - - 0.0000000000000000000000006317 106.0
TLS2_k127_202525_5 - - - - 0.0000000000000001209 84.0
TLS2_k127_202525_6 DUF167 K09131 - - 0.000000000000001003 80.0
TLS2_k127_2027199_0 FecR protein - - - 3.769e-195 633.0
TLS2_k127_2027199_1 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.000000000007308 68.0
TLS2_k127_2036048_0 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 433.0
TLS2_k127_2036048_1 DNA polymerase X family K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 403.0
TLS2_k127_2036048_2 PFAM AMP-dependent synthetase and ligase K01911 - 6.2.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000985 341.0
TLS2_k127_2036048_3 DEAD DEAH box helicase domain protein K06877 - - 0.000000000000000000000000000000000000000000000000000001415 207.0
TLS2_k127_2036048_4 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000002665 201.0
TLS2_k127_2039506_0 Acetyl-CoA acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 484.0
TLS2_k127_2039506_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007087 467.0
TLS2_k127_2039506_2 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007738 344.0
TLS2_k127_2039506_3 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000003642 195.0
TLS2_k127_2039506_4 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.000000000000000000000000000000007266 132.0
TLS2_k127_2039506_5 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.000000000000000000095 93.0
TLS2_k127_2039506_6 carboxymuconolactone decarboxylase - - - 0.0000000000000000005795 92.0
TLS2_k127_2039506_8 Transposase - - - 0.000000008757 61.0
TLS2_k127_2043397_0 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 354.0
TLS2_k127_2043397_1 PFAM Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001533 267.0
TLS2_k127_2047836_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.843e-229 728.0
TLS2_k127_2047836_1 PFAM peptidase M24 K01271 - 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004773 494.0
TLS2_k127_2047836_2 ATPases associated with a variety of cellular activities K02028 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 393.0
TLS2_k127_2047836_3 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 388.0
TLS2_k127_2047836_4 COG0765 ABC-type amino acid transport system permease component K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 336.0
TLS2_k127_2047836_5 Binding-protein-dependent transport system inner membrane component K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 318.0
TLS2_k127_2047836_6 AAA domain - - - 0.0000000000000000000000000000000000005935 145.0
TLS2_k127_2047836_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000003872 55.0
TLS2_k127_2053664_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005624 267.0
TLS2_k127_2053664_1 TIGRFAM methylmalonyl-CoA mutase N-terminal domain K01847,K01848 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000000000002052 225.0
TLS2_k127_2053664_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000777 214.0
TLS2_k127_2053664_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000001758 139.0
TLS2_k127_2053839_0 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 462.0
TLS2_k127_2053839_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007222 422.0
TLS2_k127_2053839_2 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000473 295.0
TLS2_k127_2053839_3 Protein of unknown function (DUF2384) - - - 0.00000000000000000005069 97.0
TLS2_k127_2053839_4 RES - - - 0.0000000000000000005251 89.0
TLS2_k127_2053839_5 riboflavin synthase, alpha K00793 - 2.5.1.9 0.0000000000000003211 79.0
TLS2_k127_2053839_6 Methyltransferase domain - - - 0.00007344 45.0
TLS2_k127_2054851_0 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009688 308.0
TLS2_k127_2054851_1 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000004456 272.0
TLS2_k127_2054851_2 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.0000000000000000000000000000000000000000000000000005874 190.0
TLS2_k127_2054851_3 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000001253 94.0
TLS2_k127_2060017_0 Belongs to the CinA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009115 580.0
TLS2_k127_2060017_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000019 253.0
TLS2_k127_2060017_2 TRAP transporter, solute receptor (TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000001055 231.0
TLS2_k127_2060017_3 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000002877 197.0
TLS2_k127_2060017_4 Domain of unknown function DUF29 - - - 0.0000000000000000000000000000000000000006579 154.0
TLS2_k127_2060017_5 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000007593 119.0
TLS2_k127_2060017_6 nucleotidyltransferase activity K07076 - - 0.00000000000000000341 88.0
TLS2_k127_2060017_7 HEPN domain - - - 0.000000000000000004034 91.0
TLS2_k127_2070205_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972,K02342,K04096,K12472 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 434.0
TLS2_k127_2070205_1 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 371.0
TLS2_k127_2070205_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002438 249.0
TLS2_k127_2070205_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000004216 138.0
TLS2_k127_207512_0 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001439 280.0
TLS2_k127_207512_1 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000006826 136.0
TLS2_k127_207512_2 NifU-like domain K07400 - - 0.0000000000000000000000007386 108.0
TLS2_k127_207512_3 - - - - 0.000000000000000000002309 98.0
TLS2_k127_207512_4 PFAM Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000000000001298 88.0
TLS2_k127_207512_5 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0000000001758 66.0
TLS2_k127_2092614_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07644 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 487.0
TLS2_k127_2092614_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 467.0
TLS2_k127_2092614_2 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 343.0
TLS2_k127_2092614_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000002489 200.0
TLS2_k127_2092614_4 transcriptional regulator, SARP family - - - 0.0000007715 62.0
TLS2_k127_2092915_0 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 4.804e-210 663.0
TLS2_k127_2092915_1 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 469.0
TLS2_k127_2092915_2 Conserved hypothetical protein (DUF2461) - - - 0.000000000000000000000000000000000000000000000000000000000000000002011 234.0
TLS2_k127_2092915_3 - - - - 0.00000000000000000002984 92.0
TLS2_k127_2092915_4 Psort location Cytoplasmic, score 8.87 - - - 0.0000008195 57.0
TLS2_k127_2100418_0 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000002217 218.0
TLS2_k127_2100418_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000001157 171.0
TLS2_k127_2100418_2 Zinc-dependent metalloprotease - - - 0.00000000000000000000000000000000000007818 154.0
TLS2_k127_2100418_3 actin binding - - - 0.00000000000000000000000000004357 121.0
TLS2_k127_2100418_4 ThiF family - - - 0.000000000003674 70.0
TLS2_k127_2100418_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000003015 58.0
TLS2_k127_2102067_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 425.0
TLS2_k127_2102067_1 translation release factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 411.0
TLS2_k127_2102067_2 Diadenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000002725 216.0
TLS2_k127_2102067_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000001409 198.0
TLS2_k127_2102067_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000277 114.0
TLS2_k127_2108678_0 - K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 413.0
TLS2_k127_2108678_1 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002759 275.0
TLS2_k127_2108678_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000001547 180.0
TLS2_k127_2108678_3 NIPSNAP - - - 0.00000000000000000000000000000000001252 138.0
TLS2_k127_2108678_4 inositol 2-dehydrogenase activity - - - 0.000000000000000000000000001222 120.0
TLS2_k127_2112320_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 331.0
TLS2_k127_2112320_1 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000008115 205.0
TLS2_k127_2112320_2 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000001667 185.0
TLS2_k127_2112320_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000005027 147.0
TLS2_k127_2112320_4 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000000002512 111.0
TLS2_k127_2112320_6 PFAM short chain dehydrogenase - - - 0.00000000000002302 76.0
TLS2_k127_2112320_7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor - - - 0.0003282 49.0
TLS2_k127_2129735_0 Superfamily II DNA RNA helicases, SNF2 family - - - 0.0 1062.0
TLS2_k127_2129735_1 peptidase, M20 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 569.0
TLS2_k127_2129735_2 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004579 285.0
TLS2_k127_2129735_4 Rhodanese Homology Domain K01011 GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016782,GO:0016783,GO:0016784,GO:0031668,GO:0033554,GO:0034641,GO:0042221,GO:0042262,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 2.8.1.1,2.8.1.2 0.00000000000000000000000000005385 120.0
TLS2_k127_2129735_5 - - - - 0.00000000000004976 74.0
TLS2_k127_2129735_6 - - - - 0.000000000002683 71.0
TLS2_k127_2129735_8 Protein of unknown function (DUF433) - - - 0.000001619 54.0
TLS2_k127_2135456_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1090.0
TLS2_k127_2135456_1 COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 351.0
TLS2_k127_2135456_2 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 344.0
TLS2_k127_2135456_3 Major Facilitator Superfamily - - - 0.000001893 53.0
TLS2_k127_2145064_0 Multidrug ABC transporter ATP-binding protein K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 492.0
TLS2_k127_2145064_1 MbtH-like protein K05375 - - 0.00000000000000000000000000000004335 126.0
TLS2_k127_2145064_2 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000004907 90.0
TLS2_k127_2145064_3 Glucose dehydrogenase C-terminus - - - 0.0000007855 53.0
TLS2_k127_2145800_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007967 432.0
TLS2_k127_2145800_1 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001943 253.0
TLS2_k127_2147054_0 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07544,K07749 - 2.8.3.15,2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 576.0
TLS2_k127_2147054_1 pyrroloquinoline quinone binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001222 266.0
TLS2_k127_2147054_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000001422 228.0
TLS2_k127_2147054_3 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000006584 188.0
TLS2_k127_2147054_4 Bifunctional nuclease K08999 - - 0.000000000003366 69.0
TLS2_k127_2188186_0 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 563.0
TLS2_k127_2188186_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 534.0
TLS2_k127_2188186_2 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 464.0
TLS2_k127_2188186_3 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000004552 178.0
TLS2_k127_2188186_4 AAA ATPase domain - - - 0.00000000000000000000000000000005039 133.0
TLS2_k127_2188186_5 Lysin motif - - - 0.0000000000000000004936 93.0
TLS2_k127_2189647_0 unfolded protein binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 478.0
TLS2_k127_2189647_1 transposition, DNA-mediated K02529,K20971 - - 0.0000000000005127 77.0
TLS2_k127_2189647_3 transposition, DNA-mediated - - - 0.00000000468 64.0
TLS2_k127_2234714_0 Transposase DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002382 280.0
TLS2_k127_2234714_1 SPTR Transcriptional regulator, AraC family K07506 - - 0.000000000000003156 83.0
TLS2_k127_2250655_0 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family - - - 3.433e-194 614.0
TLS2_k127_2250655_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004023 271.0
TLS2_k127_2250655_2 PFAM luciferase-like - - - 0.000000000000000000000000000000000000000000000000000006065 198.0
TLS2_k127_2250655_3 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000664 86.0
TLS2_k127_2253936_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 614.0
TLS2_k127_2253936_1 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 427.0
TLS2_k127_2253936_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 424.0
TLS2_k127_2253936_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 362.0
TLS2_k127_2253936_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008635 286.0
TLS2_k127_2253936_5 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000237 260.0
TLS2_k127_2253936_6 - K00241 - - 0.0000000000000000000000000000000000000000000995 168.0
TLS2_k127_2253936_7 metal-dependent phosphoesterases (PHP family) - - - 0.000000000000002597 83.0
TLS2_k127_2262039_0 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005074 511.0
TLS2_k127_2262039_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 408.0
TLS2_k127_2262039_2 PFAM cobalamin (vitamin B12) biosynthesis CbiX K03795 - 4.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 342.0
TLS2_k127_2262039_3 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000006877 178.0
TLS2_k127_2262039_4 - - - - 0.00000000000000000000000001806 122.0
TLS2_k127_2262039_5 Phosphoglycerate mutase family K02226 - 3.1.3.73 0.00000001092 58.0
TLS2_k127_2268883_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006159 400.0
TLS2_k127_2268883_1 PAC2 family - - - 0.00000000000000000000000000000000000000000000000000000000000004142 225.0
TLS2_k127_2268883_2 dTDP biosynthetic process K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000006436 192.0
TLS2_k127_2268883_3 Belongs to the phosphoglycerate mutase family - - - 0.0000000000000000000000000000006549 130.0
TLS2_k127_2268883_4 transcriptional regulator K22491 - - 0.0000001395 55.0
TLS2_k127_2270649_0 Belongs to the mandelate racemase muconate lactonizing enzyme family K20023 - 4.2.1.156,4.2.1.42 0.0000000000000000000000000000000000000000000000000000002383 206.0
TLS2_k127_2270649_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000003476 166.0
TLS2_k127_227792_0 Thiamine pyrophosphate enzyme, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 338.0
TLS2_k127_227792_1 Diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000006189 235.0
TLS2_k127_2281504_0 mRNA cleavage and polyadenylation factor CLP1 P-loop K06947 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 293.0
TLS2_k127_2281504_1 Short-chain dehydrogenase reductase (SDR) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002879 272.0
TLS2_k127_2281504_2 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000004832 189.0
TLS2_k127_2281504_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000004834 142.0
TLS2_k127_2281504_4 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.000000000000000000000000000000007097 138.0
TLS2_k127_2281504_5 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.00000000000000004127 91.0
TLS2_k127_2284654_0 TIGRFAM glycine betaine L-proline transport ATP binding subunit K02000 - 3.6.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 401.0
TLS2_k127_2284654_1 PFAM Substrate-binding region of ABC-type glycine betaine transport system K02002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 356.0
TLS2_k127_2284654_2 PFAM binding-protein-dependent transport systems inner membrane component K02001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 354.0
TLS2_k127_2284654_3 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.00000000000000000000000000000000000004661 146.0
TLS2_k127_2286891_0 COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 421.0
TLS2_k127_2286891_1 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 383.0
TLS2_k127_2286891_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000279 102.0
TLS2_k127_2286891_3 - - - - 0.0000002924 53.0
TLS2_k127_2298245_0 radical SAM K06871 - - 2.599e-194 615.0
TLS2_k127_2298245_1 overlaps another CDS with the same product name - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005111 439.0
TLS2_k127_2298245_2 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007889 422.0
TLS2_k127_2298245_3 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 289.0
TLS2_k127_2298245_4 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000001714 235.0
TLS2_k127_2298245_5 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000004184 224.0
TLS2_k127_2298245_6 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000004057 220.0
TLS2_k127_2298245_7 Belongs to the peptidase S16 family - - - 0.00000000000000000000000000000000000000000000000000000004383 208.0
TLS2_k127_2298281_0 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 3.19e-204 647.0
TLS2_k127_2298281_1 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 408.0
TLS2_k127_2298281_2 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 375.0
TLS2_k127_2298281_3 Bacterial transglutaminase-like N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002118 352.0
TLS2_k127_2298281_4 Arylsulfotransferase (ASST) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 295.0
TLS2_k127_2298281_5 Surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002478 277.0
TLS2_k127_2298281_6 COG3540 Phosphodiesterase alkaline phosphatase D - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002498 269.0
TLS2_k127_2298281_7 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000896 94.0
TLS2_k127_2298281_9 Peptidoglycan binding domain - - - 0.00000007967 62.0
TLS2_k127_2309623_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005799 251.0
TLS2_k127_2309623_1 COG2368 Aromatic ring hydroxylase K00483 - 1.14.14.9 0.000000000000000000000000000000001826 140.0
TLS2_k127_2309623_2 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000004755 133.0
TLS2_k127_2309623_3 Protein of unknown function DUF86 - - - 0.000000000000005762 75.0
TLS2_k127_2310332_0 Alkaline and neutral invertase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 394.0
TLS2_k127_2310332_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 327.0
TLS2_k127_2310332_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000002591 120.0
TLS2_k127_2310332_3 preribosome binding K07574 GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 - 0.00000000000000000000000000001498 121.0
TLS2_k127_2310332_4 belongs to the UPF0276 family K09930 - - 0.000000000000000000000000003912 123.0
TLS2_k127_23159_0 AMP-binding enzyme C-terminal domain K00666 - - 2.563e-276 858.0
TLS2_k127_23159_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 533.0
TLS2_k127_23159_2 MmgE/PrpD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000301 273.0
TLS2_k127_23159_3 epoxide hydrolase K01253 - 3.3.2.9 0.00000000000000000000000000000000000000000000000000000000000003186 217.0
TLS2_k127_2317619_0 TonB-dependent Receptor Plug Domain K02014 - - 0.00000000000000000000000000000000000000001928 162.0
TLS2_k127_2317619_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000002532 131.0
TLS2_k127_2317619_2 TIGRFAM amino acid adenylation domain K16132 - - 0.00000000000000000000004192 104.0
TLS2_k127_2340579_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 3.085e-305 945.0
TLS2_k127_2340579_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 459.0
TLS2_k127_235082_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1063.0
TLS2_k127_235082_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 332.0
TLS2_k127_235082_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001786 266.0
TLS2_k127_235082_3 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000002413 165.0
TLS2_k127_2351152_0 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 3.309e-197 620.0
TLS2_k127_2351152_1 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001156 263.0
TLS2_k127_2351152_2 Proteolipid membrane potential modulator - - - 0.00000000000000000000001129 102.0
TLS2_k127_2351152_3 Universal stress protein family - - - 0.000000000000000000001657 100.0
TLS2_k127_2351152_4 Belongs to the pyruvate kinase family K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 0.00000000002255 68.0
TLS2_k127_2351152_5 PRC-barrel domain - - - 0.00002938 53.0
TLS2_k127_2357081_0 Ring hydroxylating alpha subunit (catalytic domain) K10619 - 1.14.12.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 503.0
TLS2_k127_2357081_1 ATPase associated with various cellular activities, AAA_5 - - - 0.0000000000000000000000000000000000000000000000001523 177.0
TLS2_k127_2357081_2 Ring hydroxylating beta subunit K16303 - 1.14.12.25 0.0000000000000000000000000000000000000000001812 166.0
TLS2_k127_2357081_3 proteolysis K21140,K21147 - 2.7.7.80,2.8.1.11,3.13.1.6 0.00000000000000000000000000000008902 131.0
TLS2_k127_2369474_0 PFAM glycosyl hydrolase BNR repeat-containing protein - - - 0.0 1111.0
TLS2_k127_2369474_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins - - - 0.0000000000000000000000000000000000000000000000000001261 192.0
TLS2_k127_2369474_2 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000001782 141.0
TLS2_k127_2375496_0 Acetyl xylan esterase (AXE1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002532 278.0
TLS2_k127_2375496_1 cephalosporin-C deacetylase activity K01060 - 3.1.1.41 0.000000000000000000000000000002956 126.0
TLS2_k127_2375496_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000005881 76.0
TLS2_k127_241506_0 Tryptophan halogenase K21256 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 326.0
TLS2_k127_241506_1 PFAM Binding-protein-dependent transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009691 281.0
TLS2_k127_241506_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000004388 232.0
TLS2_k127_241506_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000002355 227.0
TLS2_k127_241506_4 BtpA family K06971 - - 0.000001164 53.0
TLS2_k127_241506_5 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00002191 47.0
TLS2_k127_2468529_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 5.843e-246 771.0
TLS2_k127_2468529_1 L-lactate permease K03303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 529.0
TLS2_k127_2468529_2 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K03778 - 1.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005664 472.0
TLS2_k127_2468529_3 Phosphofructokinase K00850 - 2.7.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 390.0
TLS2_k127_2468529_4 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004037 320.0
TLS2_k127_2468529_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000005137 96.0
TLS2_k127_2513133_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004086 286.0
TLS2_k127_2513133_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000003523 246.0
TLS2_k127_2513133_2 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000002418 111.0
TLS2_k127_2513133_3 helix_turn_helix, arabinose operon control protein K07506 - - 0.0000000000000000000004384 107.0
TLS2_k127_2513133_4 MotA/TolQ/ExbB proton channel family K03561 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000001467 84.0
TLS2_k127_2514207_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 614.0
TLS2_k127_2514207_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 519.0
TLS2_k127_2514207_10 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000001742 162.0
TLS2_k127_2514207_11 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000002751 118.0
TLS2_k127_2514207_12 ribosome binding K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000004204 117.0
TLS2_k127_2514207_13 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000002549 83.0
TLS2_k127_2514207_14 Belongs to the UPF0102 family K07460 - - 0.000000004842 61.0
TLS2_k127_2514207_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 399.0
TLS2_k127_2514207_3 Belongs to the ribulose-phosphate 3-epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001566 276.0
TLS2_k127_2514207_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008769 279.0
TLS2_k127_2514207_5 tRNA (Guanine-1)-methyltransferase K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000239 269.0
TLS2_k127_2514207_6 GTPase activity K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000248 229.0
TLS2_k127_2514207_7 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000000000000000003383 204.0
TLS2_k127_2514207_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000001292 207.0
TLS2_k127_2514207_9 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000001923 169.0
TLS2_k127_2529512_0 COG0657 Esterase lipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 368.0
TLS2_k127_2529512_1 NIPSNAP - - - 0.000000000000000000000000000000000000000000000001192 181.0
TLS2_k127_2529512_2 RNA recognition motif - - - 0.00000000000000000000000002937 111.0
TLS2_k127_2529512_3 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.0000000000000000000001482 101.0
TLS2_k127_2531253_0 serine-type D-Ala-D-Ala carboxypeptidase activity K05366 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000002066 271.0
TLS2_k127_2531253_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000004008 246.0
TLS2_k127_2531253_2 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000002214 180.0
TLS2_k127_2531253_3 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000005083 130.0
TLS2_k127_2531253_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000001424 76.0
TLS2_k127_25715_0 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 332.0
TLS2_k127_25715_1 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K11177 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 290.0
TLS2_k127_25715_2 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009485 271.0
TLS2_k127_25715_3 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000008746 248.0
TLS2_k127_25715_4 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000008817 238.0
TLS2_k127_25715_5 Cys-tRNA(Pro) hydrolase activity K03976,K19055 - - 0.000000000000000000000000000000000000000000000000000000000000254 215.0
TLS2_k127_25715_6 Pfam:Methyltransf_26 - - - 0.000000000000000000000000000000000000009719 157.0
TLS2_k127_25715_7 manually curated - - - 0.0000000008486 70.0
TLS2_k127_25715_8 - - - - 0.000002884 50.0
TLS2_k127_2572278_0 PFAM amidohydrolase 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 376.0
TLS2_k127_2572278_1 EamA-like transporter family - - - 0.000000000000002597 83.0
TLS2_k127_2572278_2 Pfam Amidohydrolase - - - 0.0000000000328 64.0
TLS2_k127_25794_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 608.0
TLS2_k127_25794_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 348.0
TLS2_k127_25794_2 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 309.0
TLS2_k127_25794_3 Belongs to the enoyl-CoA hydratase isomerase family K08299 - 4.2.1.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 296.0
TLS2_k127_25794_4 metallopeptidase activity K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001135 256.0
TLS2_k127_25794_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000005881 118.0
TLS2_k127_25794_6 Cupin 2, conserved barrel domain protein - - - 0.0000000000000001034 84.0
TLS2_k127_25794_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000001548 70.0
TLS2_k127_25794_8 Protein of unknown function, DUF488 - - - 0.000000001653 64.0
TLS2_k127_2617344_0 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 405.0
TLS2_k127_2617344_1 CoA-transferase family III K07544 - 2.8.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000001092 259.0
TLS2_k127_2617344_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000001811 195.0
TLS2_k127_2617344_3 SnoaL-like domain - - - 0.0000000000000000418 85.0
TLS2_k127_2665663_0 SPTR Alr4702 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 469.0
TLS2_k127_2680538_0 sodium:proton antiporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 500.0
TLS2_k127_2680538_1 domain protein K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 471.0
TLS2_k127_2680538_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 298.0
TLS2_k127_2681882_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 430.0
TLS2_k127_2681882_1 ABC transporter ATP-binding protein K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002719 266.0
TLS2_k127_2681882_2 Protein of unknown function (DUF2796) - - - 0.00000000000000000000000000005874 123.0
TLS2_k127_2683018_0 COG0687 Spermidine putrescine-binding periplasmic protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009157 543.0
TLS2_k127_2683018_1 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 361.0
TLS2_k127_2683018_2 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 349.0
TLS2_k127_2683018_3 TOBE domain K02052,K11072 - 3.6.3.31 0.00000000000000000000000006704 109.0
TLS2_k127_2695804_0 PFAM Conserved region in glutamate synthase K00284 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.7.1 0.0 1185.0
TLS2_k127_2695804_1 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 475.0
TLS2_k127_2697376_0 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 453.0
TLS2_k127_2697376_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000002418 246.0
TLS2_k127_2697376_2 TLC ATP/ADP transporter - - - 0.000000000000000000000000000001441 137.0
TLS2_k127_271136_0 SpoVR like protein K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 606.0
TLS2_k127_271136_1 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 447.0
TLS2_k127_271136_2 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 409.0
TLS2_k127_271136_3 PrkA family serine protein kinase K07180 GO:0003674,GO:0003824,GO:0004672,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0042594,GO:0043170,GO:0043412,GO:0043562,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000001656 241.0
TLS2_k127_2714772_0 Aconitase C-terminal domain K01681 - 4.2.1.3 1.625e-257 808.0
TLS2_k127_2714772_1 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 546.0
TLS2_k127_2714772_10 ROS/MUCR transcriptional regulator protein - - - 0.00000000000001297 82.0
TLS2_k127_2714772_2 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 320.0
TLS2_k127_2714772_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 305.0
TLS2_k127_2714772_4 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004103 268.0
TLS2_k127_2714772_5 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.000000000000000000000000000000000000000000000000005315 188.0
TLS2_k127_2714772_6 Bacterial transcriptional repressor C-terminal - - - 0.000000000000000000000000000000009319 131.0
TLS2_k127_2714772_7 PrpF protein - - - 0.000000000000000000107 92.0
TLS2_k127_2714772_8 Protein of unknown function (DUF2845) - - - 0.00000000000000008932 83.0
TLS2_k127_2714772_9 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05787 - - 0.000000000000001048 81.0
TLS2_k127_2716800_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.361e-224 700.0
TLS2_k127_2716800_1 translation release factor activity K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004859 416.0
TLS2_k127_2716800_2 MoeA domain protein domain I and II K03750,K15376 - 2.10.1.1,2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 376.0
TLS2_k127_2716800_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000002406 242.0
TLS2_k127_2716800_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000007784 218.0
TLS2_k127_2716800_5 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000004454 166.0
TLS2_k127_2716800_6 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.0000000000000000000000000000000000001853 143.0
TLS2_k127_2716800_7 PFAM purine or other phosphorylase family 1 - - - 0.00000000000000000000000000000003539 138.0
TLS2_k127_2716800_8 Binds the 23S rRNA K02909 - - 0.00000000000000000000000005355 109.0
TLS2_k127_2733699_0 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001722 285.0
TLS2_k127_2733699_1 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000001033 194.0
TLS2_k127_2733699_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000006093 121.0
TLS2_k127_2733699_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000008996 67.0
TLS2_k127_2750651_0 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 411.0
TLS2_k127_2750651_1 ATPase activity K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 317.0
TLS2_k127_2750651_2 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000002704 184.0
TLS2_k127_2781576_0 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 315.0
TLS2_k127_2781576_1 NADPH regeneration - GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016491,GO:0019362,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901360,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000006131 249.0
TLS2_k127_2781576_2 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000005345 198.0
TLS2_k127_2781576_3 B12 binding domain K04034 - 1.21.98.3 0.0000000000000000000000008829 110.0
TLS2_k127_2791968_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 546.0
TLS2_k127_2791968_1 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.000000000000000000000000000000000000000000000000000000000000000000000000000002654 277.0
TLS2_k127_2791968_2 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051234,GO:0051641,GO:0055085,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0097159,GO:0097367,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1990778 - 0.0000000000000000000000000000000000000000000000000000000000000003839 229.0
TLS2_k127_2791968_3 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000001622 199.0
TLS2_k127_2791968_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000003558 152.0
TLS2_k127_280916_0 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 413.0
TLS2_k127_280916_1 Histidine kinase K02668,K07709,K07710 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000005984 277.0
TLS2_k127_280916_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000004232 64.0
TLS2_k127_2811621_0 Acyl transferase domain K15314 - - 0.0 1675.0
TLS2_k127_2811621_1 Tryptophan halogenase K14257 - 1.14.19.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 454.0
TLS2_k127_2811621_11 - - - - 0.00000000000000003622 87.0
TLS2_k127_2811621_12 PFAM Taurine catabolism dioxygenase TauD TfdA K03119 - 1.14.11.17 0.00000000000000007288 91.0
TLS2_k127_2811621_2 Ketose-bisphosphate aldolase class-II family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008184 372.0
TLS2_k127_2811621_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 358.0
TLS2_k127_2811621_4 Protein of unknown function (DUF1800) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 302.0
TLS2_k127_2811621_5 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008294 294.0
TLS2_k127_2811621_6 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000002991 210.0
TLS2_k127_2811621_7 Polyketide synthase dehydratase - - - 0.0000000000000000000000000000788 122.0
TLS2_k127_2811621_8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000000000000000000001595 109.0
TLS2_k127_2811621_9 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000004698 97.0
TLS2_k127_2816077_0 DNA topoisomerase type I activity K03168 - 5.99.1.2 3.157e-272 857.0
TLS2_k127_2816077_1 penicillin binding K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 499.0
TLS2_k127_2816077_10 metalloendopeptidase activity K08602 - - 0.0000002811 61.0
TLS2_k127_2816077_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 351.0
TLS2_k127_2816077_3 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006226 311.0
TLS2_k127_2816077_4 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 310.0
TLS2_k127_2816077_5 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 297.0
TLS2_k127_2816077_6 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000006636 185.0
TLS2_k127_2816077_7 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000005323 128.0
TLS2_k127_2816077_8 LysM domain - - - 0.000000000007684 78.0
TLS2_k127_2816077_9 LysM domain - - - 0.000000003613 69.0
TLS2_k127_2839163_0 Major facilitator superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000009737 244.0
TLS2_k127_2839163_1 dna ligase K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000000000000000000000000000000000000000002368 190.0
TLS2_k127_2839163_2 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000008495 141.0
TLS2_k127_2848026_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 2.19e-321 1001.0
TLS2_k127_2848026_1 Belongs to the amidase family K01426 - 3.5.1.4 1.018e-254 799.0
TLS2_k127_2848026_2 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 533.0
TLS2_k127_2848026_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 302.0
TLS2_k127_2848026_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002683 256.0
TLS2_k127_2848026_5 ABC transporter permease K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003651 251.0
TLS2_k127_2848026_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000008227 211.0
TLS2_k127_2848026_7 Toxin-antitoxin system, toxin component, PIN family - - - 0.00000000000001116 76.0
TLS2_k127_2848856_0 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 434.0
TLS2_k127_2848856_1 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 306.0
TLS2_k127_2848856_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000008508 228.0
TLS2_k127_2848856_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000001156 96.0
TLS2_k127_2848856_4 Heme iron utilization protein - - - 0.000000000000004164 80.0
TLS2_k127_2861601_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 555.0
TLS2_k127_2861601_1 Protein of unknown function (DUF1688) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 441.0
TLS2_k127_2861601_10 Cysteine-rich secretory protein family - - - 0.000000000000000000000000000006822 128.0
TLS2_k127_2861601_11 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000001006 86.0
TLS2_k127_2861601_2 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 434.0
TLS2_k127_2861601_3 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 384.0
TLS2_k127_2861601_4 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008697 376.0
TLS2_k127_2861601_5 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 346.0
TLS2_k127_2861601_6 Steryl acetyl hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 314.0
TLS2_k127_2861601_7 PFAM response regulator receiver K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002954 301.0
TLS2_k127_2861601_8 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - - 0.0000000000000000000000000000000000000000000000000000001383 200.0
TLS2_k127_2861601_9 COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain K02030 - - 0.0000000000000000000000000000000000000000001026 170.0
TLS2_k127_2875431_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 423.0
TLS2_k127_2875431_1 Nucleoside 2-deoxyribosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004512 240.0
TLS2_k127_2875431_2 - - - - 0.000000000000000000001456 97.0
TLS2_k127_2875431_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000009497 59.0
TLS2_k127_2878871_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 600.0
TLS2_k127_2878871_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family K18896 - 2.1.1.156 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 486.0
TLS2_k127_2878871_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008202 370.0
TLS2_k127_2878871_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000001338 181.0
TLS2_k127_2878871_4 DNA binding - - - 0.00000000000000000000000000000000000000000009215 172.0
TLS2_k127_2878871_5 Tfp pilus assembly protein K08086 - - 0.000000002727 68.0
TLS2_k127_2894543_0 Acyl-CoA dehydrogenase, C-terminal domain K14448 - 1.3.8.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 421.0
TLS2_k127_2894543_1 N-acyl-D-aspartate D-glutamate deacylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002607 267.0
TLS2_k127_2894543_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000001998 269.0
TLS2_k127_289998_0 transposase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 432.0
TLS2_k127_289998_1 transposition, DNA-mediated K02529,K20971 - - 0.000000000000000000000000000000000000000000000000000000000000004339 233.0
TLS2_k127_289998_2 IMG reference gene - - - 0.000000000000002256 87.0
TLS2_k127_2917752_0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 585.0
TLS2_k127_2917752_1 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 441.0
TLS2_k127_2917752_2 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000001033 188.0
TLS2_k127_2917752_3 PFAM UspA domain protein K06149 - - 0.00000000000000000000009056 104.0
TLS2_k127_2922936_0 Ethanolamine ammonia lyase large subunit (EutB) K03735 - 4.3.1.7 8.653e-315 979.0
TLS2_k127_2922936_1 acetyl-coa acetyltransferase - - - 5.677e-195 616.0
TLS2_k127_2922936_10 Cobalamin adenosyltransferase - - - 0.000000000000000000000000000000000000000000001749 171.0
TLS2_k127_2922936_11 MDMPI C-terminal domain - - - 0.000000000000000000000000000000000000000000004629 172.0
TLS2_k127_2922936_12 O-methyltransferase K15256 - - 0.00000000000000000000000001402 119.0
TLS2_k127_2922936_13 ROS/MUCR transcriptional regulator protein - - - 0.0000000000000000000000419 104.0
TLS2_k127_2922936_14 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000003899 48.0
TLS2_k127_2922936_2 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001645 272.0
TLS2_k127_2922936_3 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000001994 249.0
TLS2_k127_2922936_4 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000005869 238.0
TLS2_k127_2922936_5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000009521 222.0
TLS2_k127_2922936_6 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.00000000000000000000000000000000000000000000000000000000002939 213.0
TLS2_k127_2922936_7 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000000000000000000000000000000008574 209.0
TLS2_k127_2922936_8 PFAM Adenosylcobinamide amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000002744 211.0
TLS2_k127_2922936_9 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000001188 194.0
TLS2_k127_2929906_0 IS1 transposase K07480 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008285 246.0
TLS2_k127_2929906_1 InsA C-terminal domain - - - 0.0000000000000000000000006156 107.0
TLS2_k127_2929906_2 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000005584 97.0
TLS2_k127_2929906_3 - - - - 0.000000000000000004882 90.0
TLS2_k127_2929906_4 Transposase - - - 0.00000000000000002839 82.0
TLS2_k127_2929906_5 - - - - 0.00000000229 65.0
TLS2_k127_293379_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 4.2e-280 897.0
TLS2_k127_293379_1 drug transmembrane transporter activity K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005739 333.0
TLS2_k127_293379_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000006024 178.0
TLS2_k127_293379_3 COG2193 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.00000000000000003924 87.0
TLS2_k127_293379_4 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00008728 52.0
TLS2_k127_2944226_0 Belongs to the class-I aminoacyl-tRNA synthetase family K15526 - 6.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 437.0
TLS2_k127_2944226_1 protein histidine kinase activity K03407,K07678 - 2.7.13.3 0.0000000000000000000000000002653 118.0
TLS2_k127_2944226_2 Rhodanese Homology Domain K03972 GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.000000000000000000000003004 108.0
TLS2_k127_2944226_3 Universal stress protein family - - - 0.0000000000000000000009512 101.0
TLS2_k127_2944226_4 COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein - - - 0.00000000000005392 81.0
TLS2_k127_2952741_0 Amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009365 559.0
TLS2_k127_2952741_1 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 501.0
TLS2_k127_2952741_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 323.0
TLS2_k127_2952741_3 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 294.0
TLS2_k127_2952741_4 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000006731 275.0
TLS2_k127_2952741_5 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001569 269.0
TLS2_k127_2952741_6 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000002173 154.0
TLS2_k127_2952741_7 Belongs to the HpcH HpaI aldolase family K00979,K02510 - 2.7.7.38,4.1.2.52 0.00000000000000000000000000000000781 134.0
TLS2_k127_295656_0 hmm pf02371 K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 317.0
TLS2_k127_295656_1 Transposase DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007332 288.0
TLS2_k127_295656_2 Retinal pigment epithelial membrane protein - - - 0.0000000000000000000000000000000000000000000000000000000000000006572 226.0
TLS2_k127_295656_3 membrane - - - 0.000000000000000000000000000000000000000000000000003397 186.0
TLS2_k127_295656_4 epimerase - - - 0.000000000000000000000000000000001018 130.0
TLS2_k127_2962824_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 403.0
TLS2_k127_2962824_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000003947 194.0
TLS2_k127_2962824_2 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway - - - 0.0000000000000000000000000000000000000000000000003984 186.0
TLS2_k127_2962824_3 IS1 transposase K07480 - - 0.00000000000000000000000000000000006954 137.0
TLS2_k127_2962824_4 PFAM IS1 transposase - - - 0.00000000000000000000001402 100.0
TLS2_k127_2962824_5 InsA C-terminal domain - - - 0.00000000000000000000005921 101.0
TLS2_k127_2962824_6 transposition, DNA-mediated K02529,K20971 - - 0.0000000003303 64.0
TLS2_k127_2966503_0 Glycosyl hydrolases family 15 - - - 5.401e-250 786.0
TLS2_k127_2966503_1 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 506.0
TLS2_k127_2966503_2 PFAM Glycosyl transferase, family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003951 276.0
TLS2_k127_2966503_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000005329 209.0
TLS2_k127_296789_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015,K00018 - 1.1.1.26,1.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 406.0
TLS2_k127_296789_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 347.0
TLS2_k127_296789_2 Belongs to the MT-A70-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 305.0
TLS2_k127_296789_3 Tetrapyrrole (Corrin/Porphyrin) Methylases K01719,K01749,K02303,K13542,K13543 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.000000000000000000000000000000000000000000000000000000000001626 218.0
TLS2_k127_296789_4 Superfamily II DNA RNA helicases, SNF2 family - - - 0.000000000000000000000000000000000000000000000000003947 194.0
TLS2_k127_296789_5 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000001002 145.0
TLS2_k127_296789_6 Ankyrin repeat domain 52 K15504 - - 0.00000003189 60.0
TLS2_k127_2975616_0 PFAM aminotransferase, class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 425.0
TLS2_k127_2975616_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000003031 172.0
TLS2_k127_2975616_2 Radical SAM superfamily K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000001251 117.0
TLS2_k127_2976935_0 Dynamin family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 580.0
TLS2_k127_2976935_1 ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 413.0
TLS2_k127_2976935_2 Domain of unknown function DUF29 - - - 0.0000000000000000000000000000002636 128.0
TLS2_k127_2976935_3 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000000000000000000000000000673 124.0
TLS2_k127_2976935_4 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000009302 114.0
TLS2_k127_2976935_5 - - - - 0.000000000000129 73.0
TLS2_k127_2976935_6 PFAM nitrogen-fixing NifU domain protein K07400 - - 0.000009793 48.0
TLS2_k127_2986144_0 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002482 252.0
TLS2_k127_2986144_1 PFAM Transposase IS66 family - - - 0.00000000000000000000000000000000003192 149.0
TLS2_k127_2986144_2 PIN domain K18828 - - 0.0000000000000000000000000000000172 131.0
TLS2_k127_2986144_3 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000008126 118.0
TLS2_k127_2986144_4 - - - - 0.0000000000001888 71.0
TLS2_k127_2986144_6 Integrase core domain - - - 0.0000000009836 61.0
TLS2_k127_2986144_7 Integrase core domain - - - 0.00008661 46.0
TLS2_k127_2986144_8 - - - - 0.0004679 46.0
TLS2_k127_2986144_9 Transposase K07481 - - 0.0005693 43.0
TLS2_k127_2986790_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 474.0
TLS2_k127_2986790_1 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 361.0
TLS2_k127_2986790_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 297.0
TLS2_k127_2986790_3 unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005585 288.0
TLS2_k127_2991380_0 peptidyl-lysine modification to peptidyl-hypusine K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 418.0
TLS2_k127_2991380_1 COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006349 410.0
TLS2_k127_2998820_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 416.0
TLS2_k127_2998820_1 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000001434 259.0
TLS2_k127_2998820_2 PFAM LmbE family protein - - - 0.000000000000000000000000000000000000000000000000000000000003054 219.0
TLS2_k127_2998820_3 MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000001133 159.0
TLS2_k127_2998820_4 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000003827 66.0
TLS2_k127_2998820_5 energy transducer activity K03832 - - 0.000005534 57.0
TLS2_k127_2998820_6 PFAM NAD dependent epimerase dehydratase family - - - 0.00002798 48.0
TLS2_k127_2998820_7 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00003749 51.0
TLS2_k127_2998820_8 Flagellar protein YcgR - - - 0.0003254 48.0
TLS2_k127_3006860_0 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 477.0
TLS2_k127_3006860_1 Reductase C-terminal K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007177 287.0
TLS2_k127_3006860_2 Belongs to the UPF0109 family K06960 - - 0.0000000000000000000001235 98.0
TLS2_k127_30117_0 Zinc-uptake complex component A periplasmic - - - 0.00000000000000000000000000000000000000000000000000000000000000000001494 243.0
TLS2_k127_30117_1 TIGRFAM DNA binding domain - - - 0.0000000000000000003167 89.0
TLS2_k127_3042750_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 1.189e-237 741.0
TLS2_k127_3042750_1 cytochrome P450 K16593 GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.14.14.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 349.0
TLS2_k127_3042750_2 Metallo-beta-lactamase superfamily K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000001159 268.0
TLS2_k127_3042750_3 Nitrogen regulatory protein P-II K04751 - - 0.00000000000000000000000000000000000000000000000001856 183.0
TLS2_k127_3042750_4 DSBA-like thioredoxin domain - - - 0.00000000000000000000002932 107.0
TLS2_k127_3042750_5 - - - - 0.000000000000000002387 93.0
TLS2_k127_3042750_6 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000002401 90.0
TLS2_k127_3050250_0 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 GO:0001539,GO:0005575,GO:0005576,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009420,GO:0009421,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - 0.000000001638 69.0
TLS2_k127_3056181_0 PFAM Integrase core domain - - - 3.615e-248 775.0
TLS2_k127_3056181_1 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 350.0
TLS2_k127_3056181_2 Phage integrase family K07358 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 289.0
TLS2_k127_3074268_0 UDP binding domain K02474,K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 541.0
TLS2_k127_3074268_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 359.0
TLS2_k127_3074268_2 short-chain dehydrogenase reductase SDR K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 313.0
TLS2_k127_3074268_3 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000005143 209.0
TLS2_k127_3074268_4 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000002783 220.0
TLS2_k127_3074268_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000002365 195.0
TLS2_k127_3074268_6 Thiamine pyrophosphate enzyme, central K01652 - 2.2.1.6 0.00000000000000000001932 92.0
TLS2_k127_3074268_7 - - - - 0.000000007942 59.0
TLS2_k127_3075632_0 Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 508.0
TLS2_k127_3075632_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 332.0
TLS2_k127_3075632_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000524 90.0
TLS2_k127_3075632_3 Sporulation related domain - - - 0.0000002846 61.0
TLS2_k127_3076586_0 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 337.0
TLS2_k127_3076586_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005824 318.0
TLS2_k127_3076586_2 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003503 278.0
TLS2_k127_3076586_3 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0048037,GO:0050163,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.000000000000000000000000000000000000000000000000002985 186.0
TLS2_k127_307940_0 Arylsulfatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008434 278.0
TLS2_k127_307940_1 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001382 268.0
TLS2_k127_307940_2 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000000000000000000000000000001629 211.0
TLS2_k127_307940_3 Aminotransferase class-V - - - 0.0000000000000000000000000000000008615 134.0
TLS2_k127_307940_4 Prolyl-tRNA synthetase - - - 0.0003961 46.0
TLS2_k127_307940_5 ERCC3/RAD25/XPB C-terminal helicase K10843 - 3.6.4.12 0.0007134 51.0
TLS2_k127_3080138_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007513 351.0
TLS2_k127_3080138_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000001442 147.0
TLS2_k127_3080138_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000004049 106.0
TLS2_k127_3080138_3 response regulator, receiver - - - 0.000000000000000000000001001 109.0
TLS2_k127_3080138_4 AMP binding - - - 0.000001101 58.0
TLS2_k127_3080138_5 Haem-degrading - - - 0.0007132 48.0
TLS2_k127_3085420_0 ABC transporter permease K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 314.0
TLS2_k127_3085420_1 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000001156 213.0
TLS2_k127_3085420_2 ABC-type dipeptide oligopeptide nickel transport K02034 - - 0.0000000000000000000000000000000000000000000005314 177.0
TLS2_k127_309736_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 428.0
TLS2_k127_309736_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000001628 240.0
TLS2_k127_309736_2 Domain of unknown function DUF29 - - - 0.00000000000000000000002723 102.0
TLS2_k127_309736_3 ROS/MUCR transcriptional regulator protein - - - 0.000000000000000004464 91.0
TLS2_k127_310131_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 406.0
TLS2_k127_310131_1 PIN domain - - - 0.000000000000000000005776 96.0
TLS2_k127_310131_2 SpoVT / AbrB like domain - - - 0.000000000000000009446 85.0
TLS2_k127_310131_3 ABC transporter substrate binding protein K01989 - - 0.000000000000003525 77.0
TLS2_k127_311886_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004849 417.0
TLS2_k127_3119348_0 PFAM Cytochrome c assembly protein K02198 - - 4.234e-198 638.0
TLS2_k127_3119348_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000128 99.0
TLS2_k127_3119348_2 PFAM Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.000002218 51.0
TLS2_k127_3121449_0 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 419.0
TLS2_k127_3121449_1 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000003265 230.0
TLS2_k127_3121449_2 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000000000000000000000000000001001 148.0
TLS2_k127_3126280_0 MreB/Mbl protein K04043 - - 5.411e-197 631.0
TLS2_k127_3126280_1 Amidohydrolase family K01485 - 3.5.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003436 605.0
TLS2_k127_3126280_2 MlrC C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 389.0
TLS2_k127_3126280_3 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00651 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0008899,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016750,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008921 378.0
TLS2_k127_3126280_4 Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 325.0
TLS2_k127_3126280_5 DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - 0.00000000000000000005493 93.0
TLS2_k127_3126280_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000001372 82.0
TLS2_k127_3126280_7 - - - - 0.00002946 51.0
TLS2_k127_3126280_8 Tetratricopeptide TPR_2 repeat protein - - - 0.000655 52.0
TLS2_k127_3127146_0 type III restriction enzyme, res subunit - - - 7.304e-223 700.0
TLS2_k127_3127146_1 COGs COG3372 conserved K09744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 596.0
TLS2_k127_3127146_2 Major Facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 430.0
TLS2_k127_3127146_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000005927 222.0
TLS2_k127_3127146_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000007483 144.0
TLS2_k127_3127146_5 Redoxin K03564 - 1.11.1.15 0.0000000000000000004593 89.0
TLS2_k127_3127146_6 Antioxidant, AhpC TSA family - - - 0.0000000002631 63.0
TLS2_k127_3127146_7 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000002043 62.0
TLS2_k127_3137162_0 Winged helix DNA-binding domain K09927 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009821 414.0
TLS2_k127_3137162_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 404.0
TLS2_k127_3137162_2 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 373.0
TLS2_k127_3137162_3 fumarylacetoacetate (FAA) hydrolase K16165 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 325.0
TLS2_k127_3137162_4 IMP cyclohydrolase activity K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 296.0
TLS2_k127_3137162_5 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009403 293.0
TLS2_k127_3137162_6 metalloendopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007792 260.0
TLS2_k127_3137162_7 Biotin-lipoyl like K03543 - - 0.00000000000000000000000000000000000000000000000000001197 207.0
TLS2_k127_3137162_8 TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000001343 173.0
TLS2_k127_3137162_9 - - - - 0.0000000000000000000000000965 109.0
TLS2_k127_3144154_0 B12 binding domain K04034 - 1.21.98.3 0.00000000000000000000000000000000000000000000000000008952 203.0
TLS2_k127_3144154_1 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000566 184.0
TLS2_k127_3144154_2 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000001107 95.0
TLS2_k127_3172749_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 0.0 1436.0
TLS2_k127_3172749_1 Malate/L-lactate dehydrogenase K00073,K13574 - 1.1.1.350 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 430.0
TLS2_k127_3172749_10 Inositol monophosphatase K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 0.0000000000000000000000000002792 128.0
TLS2_k127_3172749_11 Heat shock protein DnaJ domain protein K05516 - - 0.00002441 53.0
TLS2_k127_3172749_2 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007078 364.0
TLS2_k127_3172749_3 K -dependent Na Ca exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000639 356.0
TLS2_k127_3172749_4 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003949 346.0
TLS2_k127_3172749_5 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 291.0
TLS2_k127_3172749_6 ABC-type transport system involved in resistance to organic solvents permease component K02066 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004684 263.0
TLS2_k127_3172749_7 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000000000000000113 175.0
TLS2_k127_3172749_8 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000006689 164.0
TLS2_k127_3172749_9 diguanylate cyclase - - - 0.00000000000000000000000000000000316 134.0
TLS2_k127_317980_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 554.0
TLS2_k127_317980_1 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 285.0
TLS2_k127_317980_2 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000001763 185.0
TLS2_k127_317980_3 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000002579 171.0
TLS2_k127_3180505_1 L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000007081 75.0
TLS2_k127_3229601_0 COG1960 Acyl-CoA dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 514.0
TLS2_k127_3229601_1 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000001281 161.0
TLS2_k127_3247636_0 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 344.0
TLS2_k127_3247636_1 - K06992 - - 0.0000000000000000000000000000000003563 140.0
TLS2_k127_3247636_2 - - - - 0.000000000000000000000000008103 120.0
TLS2_k127_3247636_3 chlorophyll binding - - - 0.00000000000000000000000001301 119.0
TLS2_k127_3247636_4 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000004311 93.0
TLS2_k127_3276616_0 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003284 595.0
TLS2_k127_3276616_1 PFAM DNA mismatch repair protein MutS domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 526.0
TLS2_k127_3276616_2 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 388.0
TLS2_k127_3276616_3 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K03802,K05844 - 6.3.2.29,6.3.2.30 0.0000000000000000000000000000000000000000000000000000000000000000002735 239.0
TLS2_k127_3276616_4 lactate metabolic process - - - 0.00000000000004125 76.0
TLS2_k127_3288830_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 1.603e-305 950.0
TLS2_k127_3288830_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.917e-262 819.0
TLS2_k127_3288830_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001608 271.0
TLS2_k127_3288830_3 37-kD nucleoid-associated bacterial protein - - - 0.00000001089 67.0
TLS2_k127_3288830_4 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0001222 46.0
TLS2_k127_3322878_0 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 299.0
TLS2_k127_3322878_1 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002764 269.0
TLS2_k127_3322878_2 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000002237 184.0
TLS2_k127_3322878_3 Belongs to the Fur family K09825 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000001009 98.0
TLS2_k127_3322878_4 peptidyl-tyrosine sulfation - - - 0.000000000000000001135 88.0
TLS2_k127_3327194_0 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 461.0
TLS2_k127_3327194_1 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 447.0
TLS2_k127_3327194_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K00945,K02945,K03527 - 1.17.7.4,2.7.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 383.0
TLS2_k127_3327194_3 Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family - - - 0.0000000000000000000000000000000000000000000000227 177.0
TLS2_k127_3327194_4 Methyltransferase - - - 0.000000000000000000000000000000007011 136.0
TLS2_k127_3327194_5 Domain of unknown function (DUF4124) - - - 0.0000000000000000000000000000006644 134.0
TLS2_k127_3327194_6 Peptidase family M28 - - - 0.000000000000000000000009178 102.0
TLS2_k127_3327194_7 Dodecin K09165 - - 0.0000000000000001804 82.0
TLS2_k127_3327194_8 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01040 - 2.8.3.12 0.0005081 44.0
TLS2_k127_3331625_0 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 520.0
TLS2_k127_3331625_1 Haloacid dehalogenase, type II K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 286.0
TLS2_k127_3331625_2 N-acetyl-alpha-D-glucosaminyl L-malate synthase K00754 GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000000000000000000000000000000000000000000000000000000000008087 227.0
TLS2_k127_3331625_3 N-acetylglucosaminylinositol deacetylase activity K01463 - - 0.0000000000000000000000000000000000000000000000000000132 199.0
TLS2_k127_3331625_4 - - - - 0.000000000000000000000000000000000000001397 160.0
TLS2_k127_3331625_5 Nitroreductase family - - - 0.0000000000000000000000000000000000893 139.0
TLS2_k127_3331625_6 GlcNAc-PI de-N-acetylase K22136 - - 0.0000000000000000000005467 99.0
TLS2_k127_3331625_7 amine dehydrogenase activity - - - 0.0000000000000008756 90.0
TLS2_k127_3331625_8 amidohydrolase - - - 0.0009906 45.0
TLS2_k127_3375525_0 ABC transporter transmembrane region - - - 0.0 1536.0
TLS2_k127_3375525_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.0000000000000000000242 98.0
TLS2_k127_3375525_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K09459 - 4.1.1.82 0.00000000000000004891 85.0
TLS2_k127_3388142_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008078 389.0
TLS2_k127_3388142_1 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 375.0
TLS2_k127_3388142_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000002117 235.0
TLS2_k127_3397336_0 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 592.0
TLS2_k127_3397336_1 Belongs to the ABC transporter superfamily K02031,K15583,K16202 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 393.0
TLS2_k127_3397336_2 ATPase domain of DNA mismatch repair MUTS family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 383.0
TLS2_k127_3397336_3 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000159 279.0
TLS2_k127_3397336_4 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000004539 141.0
TLS2_k127_3397336_5 Small Multidrug Resistance protein K03297,K11741 - - 0.0000000000000000000000000002571 117.0
TLS2_k127_340117_0 COG3387 Glucoamylase and related glycosyl K01178 - 3.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007286 599.0
TLS2_k127_340117_1 Belongs to the TPP enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004146 382.0
TLS2_k127_340117_2 TIGRFAM outer membrane autotransporter barrel - - - 0.0000000000000000006569 97.0
TLS2_k127_3404820_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1198.0
TLS2_k127_3404820_1 6-phosphofructokinase activity K00850 - 2.7.1.11 0.000000000000000000001901 98.0
TLS2_k127_3404820_2 Universal stress protein - - - 0.000000000000005799 78.0
TLS2_k127_3404820_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016491,GO:0016620,GO:0016903,GO:0019318,GO:0019319,GO:0036094,GO:0043891,GO:0044238,GO:0044281,GO:0044283,GO:0046364,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.2.1.12 0.00000007278 55.0
TLS2_k127_3405776_0 Protein of unknown function (DUF3604) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 472.0
TLS2_k127_3405776_1 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001273 276.0
TLS2_k127_3405776_2 IrrE N-terminal-like domain K07110 - - 0.00000000000000000000000000000000000000000000000000000000000003093 236.0
TLS2_k127_3405776_3 - - - - 0.0000000000000000009428 94.0
TLS2_k127_3415058_0 PFAM Sulfatase K01130 - 3.1.6.1 2.54e-279 864.0
TLS2_k127_3415058_1 von Willebrand factor, type A K07114 - - 1.36e-244 773.0
TLS2_k127_3415058_2 MCM2/3/5 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 440.0
TLS2_k127_3415058_3 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006618 378.0
TLS2_k127_3415058_4 Oxygen tolerance - - - 0.0000000000000000000000000000000000000000000000000000000000000000004657 244.0
TLS2_k127_3415058_5 Tetratricopeptide repeat K07114 - - 0.0000000000000000000000000000000000000000000000000131 187.0
TLS2_k127_3415058_6 Domain of unknown function (DUF4381) - - - 0.000000000000000000000000000000006116 136.0
TLS2_k127_3416053_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007049 466.0
TLS2_k127_3416053_1 regulation of single-species biofilm formation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006069 445.0
TLS2_k127_3416053_2 Belongs to the LDH2 MDH2 oxidoreductase family K13609,K16844 - 1.1.1.338,1.5.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 372.0
TLS2_k127_3416053_3 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000000000000000000000000001007 209.0
TLS2_k127_3420691_0 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 558.0
TLS2_k127_3420691_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 378.0
TLS2_k127_3420691_2 Cobalamin synthesis protein cobW C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 357.0
TLS2_k127_3420691_3 - - - - 0.00000000000000000000000003642 111.0
TLS2_k127_3422494_0 (ABC) transporter K06022,K06158,K10834 - 3.6.3.29,3.6.3.41 5.291e-209 667.0
TLS2_k127_3422494_1 CoA binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000081 278.0
TLS2_k127_3422494_2 tRNA wobble adenosine to inosine editing K01297,K01485,K01487,K01563,K04075,K11991 GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.4.17.13,3.5.4.1,3.5.4.3,3.5.4.33,3.8.1.5,6.3.4.19 0.00000000000000000000000000000000000000000002493 166.0
TLS2_k127_3422494_3 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000001904 124.0
TLS2_k127_3422494_4 addiction module antidote protein, CC2985 family - - - 0.000000000000000000791 89.0
TLS2_k127_3432262_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004173 498.0
TLS2_k127_3432262_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000004794 262.0
TLS2_k127_3432262_2 Rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000000000000000000001279 214.0
TLS2_k127_3432262_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000002177 184.0
TLS2_k127_3432262_4 VIT family - - - 0.0000000000001318 71.0
TLS2_k127_3442522_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 416.0
TLS2_k127_3442522_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 360.0
TLS2_k127_3442522_2 PFAM glycosyl hydrolase BNR repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001999 239.0
TLS2_k127_3442522_3 Cbs domain - - - 0.000000000000000001002 86.0
TLS2_k127_3442522_4 Belongs to the MSOX MTOX family. MTOX subfamily - - - 0.00000002817 55.0
TLS2_k127_3448078_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 581.0
TLS2_k127_3448078_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000003532 270.0
TLS2_k127_3448078_10 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00000000001628 65.0
TLS2_k127_3448078_11 Psort location CytoplasmicMembrane, score 10.00 - - - 0.000000001428 71.0
TLS2_k127_3448078_12 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000005745 69.0
TLS2_k127_3448078_13 Protein of unknown function (DUF3109) - - - 0.00001346 56.0
TLS2_k127_3448078_2 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000002068 228.0
TLS2_k127_3448078_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000000000000004471 184.0
TLS2_k127_3448078_4 MotA/TolQ/ExbB proton channel family K03561,K03562 - - 0.000000000000000000000000000000000000000897 155.0
TLS2_k127_3448078_5 Outer membrane lipoprotein - - - 0.00000000000000000000000000000000001308 156.0
TLS2_k127_3448078_6 PFAM Uncharacterised ACR, COG1259 K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000001173 137.0
TLS2_k127_3448078_7 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000002607 104.0
TLS2_k127_3448078_8 energy transducer activity K03832,K08086 - - 0.000000000000001136 87.0
TLS2_k127_3448078_9 Tetratricopeptide repeat protein - - - 0.000000000000004423 90.0
TLS2_k127_344890_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006255 402.0
TLS2_k127_344890_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 362.0
TLS2_k127_344890_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 330.0
TLS2_k127_344890_3 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.00000000000000000000000000000000000000000008399 164.0
TLS2_k127_3464667_0 COG1335 Amidases related to nicotinamidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 418.0
TLS2_k127_3464667_1 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 334.0
TLS2_k127_3464667_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000005089 143.0
TLS2_k127_3464667_3 Domain of unknown function (DUF309) K09763 - - 0.0000000001314 67.0
TLS2_k127_349740_0 RHS protein - - - 0.0 1703.0
TLS2_k127_349740_1 FG-GAP repeat - - - 0.000000000000000000000000000000000000000000001256 185.0
TLS2_k127_349740_2 domain protein - - - 0.000000002425 70.0
TLS2_k127_349740_3 domain, Protein - - - 0.000007146 49.0
TLS2_k127_3497892_0 Type II and III secretion system protein K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 355.0
TLS2_k127_3497892_1 Type IV pilus assembly protein PilM; K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001812 316.0
TLS2_k127_3497892_10 Fimbrial assembly protein (PilN) K02663 - - 0.0000000002616 68.0
TLS2_k127_3497892_11 Tetratricopeptide repeat - - - 0.000000382 58.0
TLS2_k127_3497892_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008357 314.0
TLS2_k127_3497892_3 Metallophosphoesterase, calcineurin superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000429 232.0
TLS2_k127_3497892_4 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000001484 183.0
TLS2_k127_3497892_5 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000002598 148.0
TLS2_k127_3497892_6 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000000000001874 123.0
TLS2_k127_3497892_7 Pilus assembly protein, PilP K02665 - - 0.000000000000000000000004167 108.0
TLS2_k127_3497892_8 KAP family P-loop domain - - - 0.000000000001523 77.0
TLS2_k127_3497892_9 - - - - 0.000000000003676 71.0
TLS2_k127_3516262_0 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 622.0
TLS2_k127_3516262_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042,K17468 - 2.9.1.1,4.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004085 447.0
TLS2_k127_3516262_2 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000001226 244.0
TLS2_k127_3516262_3 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000003862 215.0
TLS2_k127_3516262_4 PFAM YicC-like family, N-terminal region - - - 0.0000000000000000000000000000000000000000622 159.0
TLS2_k127_3516262_5 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000357 145.0
TLS2_k127_3516262_7 - - - - 0.0000005363 57.0
TLS2_k127_3516262_8 PFAM Colicin V production protein K03558 - - 0.0000237 54.0
TLS2_k127_352605_0 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 369.0
TLS2_k127_352605_1 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004992 286.0
TLS2_k127_352605_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005361 270.0
TLS2_k127_352605_3 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000008338 185.0
TLS2_k127_3551553_0 Belongs to the peptidase S16 family K01338,K04076,K04770 - 3.4.21.53 7.781e-232 738.0
TLS2_k127_3551553_1 Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion K02564 - 3.5.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006975 289.0
TLS2_k127_3557795_0 Alkaline phosphatase K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007473 518.0
TLS2_k127_3557795_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 489.0
TLS2_k127_3557795_2 PRC-barrel domain - - - 0.000000000000000000000000000000000000009365 153.0
TLS2_k127_3557795_3 PFAM response regulator receiver - - - 0.00000000000000001574 89.0
TLS2_k127_3558156_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 448.0
TLS2_k127_3558156_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 357.0
TLS2_k127_3558156_2 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 320.0
TLS2_k127_3558156_3 haloacid dehalogenase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005658 293.0
TLS2_k127_3558156_4 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 302.0
TLS2_k127_3558156_5 Putative methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001339 229.0
TLS2_k127_3558156_6 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.000000000000000000000000000000000000000000000000000000000000007891 220.0
TLS2_k127_3558156_7 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000007977 181.0
TLS2_k127_3558156_8 carboxymuconolactone decarboxylase - - - 0.00000000000000000000000000000006924 133.0
TLS2_k127_3558156_9 thiosulfate sulfurtransferase activity K21028 GO:0003674,GO:0003824,GO:0016740,GO:0016782,GO:0016783 2.8.1.11 0.000000000000000000000000001016 113.0
TLS2_k127_3584360_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 514.0
TLS2_k127_3584360_1 dehydratase - - - 0.00000000000000000000000000000000000003905 156.0
TLS2_k127_3584360_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000313 135.0
TLS2_k127_3584360_3 The glycine cleavage system catalyzes the degradation of glycine K00605,K06980,K22086 - 1.5.99.5,2.1.2.10 0.0000000000000000000000000000002584 128.0
TLS2_k127_3584360_4 Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium K07709 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.00000000000000000003474 92.0
TLS2_k127_359309_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 359.0
TLS2_k127_359309_1 abc transporter atp-binding protein K11085 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005053 298.0
TLS2_k127_359309_2 Permease YjgP YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000001715 217.0
TLS2_k127_3609920_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 456.0
TLS2_k127_3609920_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 348.0
TLS2_k127_3609920_2 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 337.0
TLS2_k127_3609920_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000001724 179.0
TLS2_k127_3609920_4 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000002128 169.0
TLS2_k127_3609920_5 metal-binding protein - - - 0.0000000000000000000000000001331 121.0
TLS2_k127_3609920_6 regulation of translation K03530 - - 0.000000000000000001522 86.0
TLS2_k127_3610872_0 Binding-protein-dependent transport system inner membrane component K02054 - - 0.0000000000000000000000000000000000000000000000000000000003179 214.0
TLS2_k127_3610872_1 spermidine putrescine ABC transporter, permease K02053 - - 0.000000000000000000000000000000000000000000000000000000001279 214.0
TLS2_k127_3610872_2 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 0.00000000000000000000000000000000000000000000003639 175.0
TLS2_k127_3610872_3 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000001165 172.0
TLS2_k127_3637512_0 Squalene-hopene cyclase C-terminal domain K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 588.0
TLS2_k127_3637512_1 Sigma-70, region 4 K03088 - - 0.000000000000000000000000003467 121.0
TLS2_k127_3637512_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000001492 66.0
TLS2_k127_3689450_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004975 302.0
TLS2_k127_3689450_1 Universal stress protein family K07090 - - 0.0000000000008042 78.0
TLS2_k127_3689450_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000006864 51.0
TLS2_k127_369412_0 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 3.954e-198 631.0
TLS2_k127_369412_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 469.0
TLS2_k127_369412_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 417.0
TLS2_k127_369412_3 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002271 243.0
TLS2_k127_369412_4 Uncharacterized conserved protein (DUF2203) - - - 0.000000000000000000000005308 105.0
TLS2_k127_369412_6 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 0.0000000000000000002071 94.0
TLS2_k127_369412_7 ATP-dependent helicase activity K10844 - 3.6.4.12 0.000000004342 63.0
TLS2_k127_369412_8 Peptidylprolyl isomerase K01802,K03769 - 5.2.1.8 0.000003151 58.0
TLS2_k127_3721662_0 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 387.0
TLS2_k127_3721662_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000093 239.0
TLS2_k127_3721662_2 Glycine/sarcosine/betaine reductase component B subunits K10671 - 1.21.4.2 0.000000000000000000000000000000000000000006778 162.0
TLS2_k127_372402_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0 1129.0
TLS2_k127_372402_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 548.0
TLS2_k127_372402_10 Armadillo/beta-catenin-like repeats - - - 0.000000000000000000006903 108.0
TLS2_k127_372402_11 AntiSigma factor - - - 0.00000000000000004898 91.0
TLS2_k127_372402_2 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 487.0
TLS2_k127_372402_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 378.0
TLS2_k127_372402_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 382.0
TLS2_k127_372402_5 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007149 265.0
TLS2_k127_372402_6 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000378 208.0
TLS2_k127_372402_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000003847 192.0
TLS2_k127_372402_8 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000008557 155.0
TLS2_k127_372402_9 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000005507 134.0
TLS2_k127_3737011_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 4.481e-231 726.0
TLS2_k127_3737011_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 613.0
TLS2_k127_3737011_2 overlaps another CDS with the same product name - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 450.0
TLS2_k127_3737011_3 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000000000000000008478 185.0
TLS2_k127_3744385_0 Monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 594.0
TLS2_k127_3744385_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0000166,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0016667,GO:0016668,GO:0019725,GO:0019899,GO:0032991,GO:0035375,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0070404,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001428 261.0
TLS2_k127_3756621_0 AMP-dependent synthetase - - - 2.968e-205 659.0
TLS2_k127_3756621_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 606.0
TLS2_k127_3756621_10 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000002732 182.0
TLS2_k127_3756621_11 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000000000000000000000000001457 123.0
TLS2_k127_3756621_12 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000002959 117.0
TLS2_k127_3756621_13 alpha/beta hydrolase fold - - - 0.00000000007273 68.0
TLS2_k127_3756621_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 458.0
TLS2_k127_3756621_3 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 442.0
TLS2_k127_3756621_4 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 411.0
TLS2_k127_3756621_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 413.0
TLS2_k127_3756621_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000445 396.0
TLS2_k127_3756621_7 inositol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000134 202.0
TLS2_k127_3756621_8 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.00000000000000000000000000000000000000000000000000004622 196.0
TLS2_k127_3756621_9 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000001625 194.0
TLS2_k127_3760487_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 580.0
TLS2_k127_3760487_1 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 530.0
TLS2_k127_3760487_2 PFAM Outer membrane efflux protein K15725 - - 0.0000000000000000000000000000000000000000000000000000000000001473 223.0
TLS2_k127_3760487_3 - - - - 0.0000000000000000000000000000000009349 136.0
TLS2_k127_3760487_4 Domain of unknown function (DUF4277) - - - 0.0000000000000000000000000000006944 124.0
TLS2_k127_3760487_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000000000000000002464 123.0
TLS2_k127_3760487_6 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000002643 125.0
TLS2_k127_3760487_7 Uncharacterised protein family (UPF0175) - - - 0.0000000000000000000002882 99.0
TLS2_k127_3760487_8 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.000000000000000000006207 95.0
TLS2_k127_3761_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 374.0
TLS2_k127_3761_1 Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP K01004 GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050520,GO:0071704,GO:0090407,GO:1901576 2.7.8.24 0.000000000000000000000000000000000000000000000000001159 191.0
TLS2_k127_3761_2 - - - - 0.00000000000000000000000000000000000001143 158.0
TLS2_k127_3763943_0 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 367.0
TLS2_k127_3763943_1 Amidohydrolase family - - - 0.000000000000000000003155 96.0
TLS2_k127_3763943_2 Tetratricopeptide repeat - - - 0.0000000000000231 80.0
TLS2_k127_3763943_3 2-methylcitrate dehydratase activity K01720 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.79 0.000000000009105 68.0
TLS2_k127_3768754_0 pfam nudix - - - 0.00000000000007489 79.0
TLS2_k127_3783437_0 ATP-dependent DNA helicase K03657 - 3.6.4.12 1.737e-211 680.0
TLS2_k127_3783437_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 474.0
TLS2_k127_3783437_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 307.0
TLS2_k127_3783437_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000003394 107.0
TLS2_k127_3783437_4 response regulator K07712 - - 0.000000000001864 76.0
TLS2_k127_3784707_0 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 359.0
TLS2_k127_3784707_1 P-aminobenzoate N-oxygenase AurF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001651 279.0
TLS2_k127_3784707_10 Protein of unknown function (DUF983) - - - 0.00000000000000002848 87.0
TLS2_k127_3784707_11 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000004286 59.0
TLS2_k127_3784707_13 integral membrane protein - - - 0.000336 52.0
TLS2_k127_3784707_2 PFAM Uracil-DNA glycosylase superfamily K03648 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000009456 245.0
TLS2_k127_3784707_3 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000004479 229.0
TLS2_k127_3784707_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000001147 200.0
TLS2_k127_3784707_5 cell redox homeostasis K02199 - - 0.0000000000000000000000000000000000000000000000000002503 197.0
TLS2_k127_3784707_6 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.0000000000000000000000000000000000000000000000002252 185.0
TLS2_k127_3784707_7 transcription activator K03707 - 3.5.99.2 0.000000000000000000000000000000004756 138.0
TLS2_k127_3784707_8 cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000008485 135.0
TLS2_k127_3784707_9 protein SCO1 SenC K07152 - - 0.0000000000000000000000000000007735 130.0
TLS2_k127_379614_0 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 436.0
TLS2_k127_379614_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000004427 228.0
TLS2_k127_379614_2 - - - - 0.000000000000000000000000000000000000000001516 171.0
TLS2_k127_379614_3 Starch synthase catalytic domain K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.00000000000000000000000000000000004486 139.0
TLS2_k127_380770_0 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 529.0
TLS2_k127_380770_1 MMPL family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 346.0
TLS2_k127_380770_2 Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate K00452 - 1.13.11.6 0.000000000000000000000000000000000000000000000000008043 187.0
TLS2_k127_380770_3 - - - - 0.0000000000000000000000000000000000000000000000001372 189.0
TLS2_k127_380770_4 Protein of unknown function DUF86 - - - 0.0000000000000000000000000000000000004912 144.0
TLS2_k127_380770_5 Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid K00486 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0019748,GO:0044550,GO:0055114 1.14.13.9 0.000000000000000000000000000001722 123.0
TLS2_k127_380770_6 nucleotidyltransferase activity - - - 0.000000000000000000000000374 110.0
TLS2_k127_380770_7 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000756 103.0
TLS2_k127_380770_8 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000004099 75.0
TLS2_k127_3821131_0 Aldo Keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 309.0
TLS2_k127_3821131_1 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000001878 106.0
TLS2_k127_3821131_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000003453 93.0
TLS2_k127_382369_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000291 235.0
TLS2_k127_382369_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000001973 120.0
TLS2_k127_382369_2 DeoR-like helix-turn-helix domain - - - 0.0000000000000000004999 92.0
TLS2_k127_382369_3 protein conserved in bacteria (DUF2325) - - - 0.0000000000000000009162 99.0
TLS2_k127_3842833_0 Belongs to the ClpA ClpB family K03695,K03696 - - 1.474e-245 771.0
TLS2_k127_3842833_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 378.0
TLS2_k127_3842833_2 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 375.0
TLS2_k127_3842833_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008019 270.0
TLS2_k127_3842833_4 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003614 258.0
TLS2_k127_3844529_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 2.217e-317 1000.0
TLS2_k127_3844529_1 Glutamine amidotransferase of anthranilate synthase K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000954 320.0
TLS2_k127_3844529_2 trans-aconitate 2-methyltransferase activity K02169 - 2.1.1.197 0.000000000000000000000000000000000000001187 153.0
TLS2_k127_3844529_3 Belongs to the UPF0109 family K06960 - - 0.0000000000000000004391 89.0
TLS2_k127_3844529_4 cheY-homologous receiver domain - - - 0.0000000000000003489 85.0
TLS2_k127_3844529_5 two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.0000000009256 63.0
TLS2_k127_3846522_0 belongs to the nudix hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 343.0
TLS2_k127_3846522_1 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000001046 153.0
TLS2_k127_3848641_0 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002891 289.0
TLS2_k127_3848641_1 Protein of unknown function (DUF1800) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003056 294.0
TLS2_k127_3857123_0 (ABC) transporter K06020 GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 1.541e-283 879.0
TLS2_k127_3857123_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000005828 133.0
TLS2_k127_3857123_2 Fe-S-cluster oxidoreductase K06940 - - 0.00000000000000000000000002893 112.0
TLS2_k127_3857123_3 PIN domain - - - 0.0000000000000000000000007026 109.0
TLS2_k127_3857123_4 Transposase - - - 0.000000000000004307 77.0
TLS2_k127_3857123_5 Ribbon-helix-helix domain - - - 0.00000000006444 65.0
TLS2_k127_3857123_6 transposition, DNA-mediated - - - 0.00000009774 59.0
TLS2_k127_3862601_0 SdrD B-like domain - - - 4.301e-210 675.0
TLS2_k127_3862601_1 R3H domain - - - 5.601e-197 626.0
TLS2_k127_3862601_10 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000006183 152.0
TLS2_k127_3862601_11 Glutamine amidotransferase class-I - - - 0.00000000000000000001208 96.0
TLS2_k127_3862601_12 - - - - 0.0000000000003975 76.0
TLS2_k127_3862601_13 L-carnitine dehydratase bile acid-inducible protein F K07749,K18313 - 2.8.3.16,2.8.3.20 0.0001663 48.0
TLS2_k127_3862601_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 585.0
TLS2_k127_3862601_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 436.0
TLS2_k127_3862601_4 Sphingolipid Delta4-desaturase (DES) K04712 - 1.14.18.5,1.14.19.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 403.0
TLS2_k127_3862601_5 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 350.0
TLS2_k127_3862601_6 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001739 253.0
TLS2_k127_3862601_7 Histidine Phosphotransfer domain - - - 0.000000000000000000000000000000000000000000000000000000525 200.0
TLS2_k127_3862601_8 HNH endonuclease - - - 0.00000000000000000000000000000000000000000156 162.0
TLS2_k127_3862601_9 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000007694 157.0
TLS2_k127_3862637_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000007038 189.0
TLS2_k127_3862637_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000006676 132.0
TLS2_k127_3862637_2 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000002959 115.0
TLS2_k127_3862637_3 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 0.00000000000005481 84.0
TLS2_k127_3862637_4 Acetyl-CoA hydrolase/transferase N-terminal domain K18122 - - 0.00000000003861 64.0
TLS2_k127_3862637_5 Type IV pilin PilA K02650 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.000003516 55.0
TLS2_k127_3862637_6 resistance - - - 0.00004738 55.0
TLS2_k127_3865686_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 566.0
TLS2_k127_3865686_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 542.0
TLS2_k127_3865686_2 Adenylosuccinate synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 526.0
TLS2_k127_3865686_3 III protein, CoA-transferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009229 505.0
TLS2_k127_3865686_4 Small-conductance mechanosensitive channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002956 280.0
TLS2_k127_3865686_5 TIGRFAM phosphate binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000002855 222.0
TLS2_k127_3865686_6 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000001088 121.0
TLS2_k127_3869374_0 Endonuclease/Exonuclease/phosphatase family K01142 GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008221 291.0
TLS2_k127_3869374_1 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004549 272.0
TLS2_k127_3869374_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000313 225.0
TLS2_k127_3869374_3 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000001728 147.0
TLS2_k127_3888425_0 TIGRFAM glutaminyl-tRNA synthetase K01886 - 6.1.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 508.0
TLS2_k127_3888425_1 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 509.0
TLS2_k127_3888425_2 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000002839 239.0
TLS2_k127_3888425_3 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000000000000000000000000001104 194.0
TLS2_k127_3888425_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000007237 190.0
TLS2_k127_3888425_5 alpha-ribazole phosphatase activity - - - 0.0000000000000000000000000002679 123.0
TLS2_k127_3894719_0 Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000001361 226.0
TLS2_k127_3894719_1 ATP hydrolysis coupled proton transport - - - 0.00000000000000000000000000000000000000000000000000000003723 218.0
TLS2_k127_3894719_2 Trehalose utilisation K09992 - - 0.000000000000000000000000000000000009999 146.0
TLS2_k127_3905683_0 benzoyl-CoA oxygenase - - - 5.726e-230 721.0
TLS2_k127_3905683_1 Enoyl-CoA hydratase/isomerase - - - 1.023e-229 724.0
TLS2_k127_3905683_2 PFAM AMP-dependent synthetase and ligase K04110 - 6.2.1.25 1.317e-229 721.0
TLS2_k127_3905683_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005975 395.0
TLS2_k127_3905683_4 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) - - - 0.000000000000000000000000000000000000000000000000000001098 195.0
TLS2_k127_3905683_5 - - - - 0.000000000000000000000000000000000000000000000000003333 190.0
TLS2_k127_3914864_0 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000002472 229.0
TLS2_k127_3914864_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000002705 176.0
TLS2_k127_3914864_2 PFAM ATPase associated with various cellular activities AAA_3 K03924 - - 0.0000000000006812 72.0
TLS2_k127_3914864_3 Domain of unknown function (DUF4129) - - - 0.00000000001416 75.0
TLS2_k127_3916559_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 3.394e-267 830.0
TLS2_k127_3916559_1 transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 291.0
TLS2_k127_3916559_2 PRC-barrel domain - - - 0.00000000000000000000000000000002846 130.0
TLS2_k127_3916559_3 - - - - 0.0002065 44.0
TLS2_k127_3920717_0 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 310.0
TLS2_k127_3920717_1 PFAM ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005724 258.0
TLS2_k127_3920717_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000009031 204.0
TLS2_k127_3920717_3 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000004006 80.0
TLS2_k127_3925283_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000922 355.0
TLS2_k127_3925283_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001301 252.0
TLS2_k127_392583_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 307.0
TLS2_k127_392583_1 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000003112 171.0
TLS2_k127_392583_2 Glyoxalase-like domain - - - 0.000000000000002513 84.0
TLS2_k127_392583_4 Amidohydrolase - - - 0.0002042 49.0
TLS2_k127_3928438_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 520.0
TLS2_k127_3928438_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 287.0
TLS2_k127_3928438_2 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000005286 203.0
TLS2_k127_3928438_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000004497 119.0
TLS2_k127_3931177_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 522.0
TLS2_k127_3931177_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000834 320.0
TLS2_k127_3943255_0 Acetolactate synthase K01652 - 2.2.1.6 6.069e-250 784.0
TLS2_k127_3943255_1 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 341.0
TLS2_k127_3943255_2 hydrolase, CocE NonD family K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 302.0
TLS2_k127_3943255_3 Carboxylate--amine ligase - - - 0.000000000000000000000000000000002652 139.0
TLS2_k127_3943255_4 Methyltransferase domain - - - 0.00000000000000000000001427 113.0
TLS2_k127_3967375_0 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 357.0
TLS2_k127_3967375_1 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 331.0
TLS2_k127_3967375_2 ASPIC and UnbV - - - 0.000000000000000000000000000000000000199 161.0
TLS2_k127_3967375_3 Tetratricopeptide repeat - - - 0.0000000000000000000001829 113.0
TLS2_k127_3972458_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0040007,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 1.351e-293 910.0
TLS2_k127_3972458_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005075 327.0
TLS2_k127_3972458_2 DAHP synthetase I family K01627 - 2.5.1.55 0.0000005898 53.0
TLS2_k127_3979429_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000009184 245.0
TLS2_k127_3979429_1 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000004775 212.0
TLS2_k127_3979429_2 reductase - - - 0.00000000000000000000000000000000000004324 154.0
TLS2_k127_3979429_3 PFAM Transposase, IS801 IS1294 - - - 0.000000000000005108 79.0
TLS2_k127_3979429_4 PFAM IS1 transposase K07480 - - 0.000006373 49.0
TLS2_k127_398112_0 PFAM Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 607.0
TLS2_k127_398112_1 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 536.0
TLS2_k127_398112_2 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 386.0
TLS2_k127_398112_3 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006188 391.0
TLS2_k127_398112_4 filamentous hemagglutinin family N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003794 294.0
TLS2_k127_398112_5 PFAM Sel1 domain protein repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000004494 236.0
TLS2_k127_398112_7 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000001088 74.0
TLS2_k127_398112_8 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.00000002647 66.0
TLS2_k127_398112_9 Transcriptional regulator - - - 0.0004467 54.0
TLS2_k127_3981223_0 FAD linked oxidases, C-terminal domain - - - 3.954e-312 985.0
TLS2_k127_3981223_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 578.0
TLS2_k127_3981223_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000007065 164.0
TLS2_k127_3981223_3 phosphatase activity K07025,K20862,K20866 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0022611,GO:0032502,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.10,3.1.3.102,3.1.3.104 0.000000000000000000000006089 109.0
TLS2_k127_3981223_4 - - - - 0.00000000007094 67.0
TLS2_k127_3981223_5 ROS/MUCR transcriptional regulator protein - - - 0.00000001765 61.0
TLS2_k127_3987905_0 Luciferase-like monooxygenase - - - 1.037e-198 624.0
TLS2_k127_3987905_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 595.0
TLS2_k127_3987905_2 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 590.0
TLS2_k127_3987905_3 ABC transporter K02000 - 3.6.3.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008489 508.0
TLS2_k127_3987905_4 PFAM Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 434.0
TLS2_k127_3987905_5 PFAM binding-protein-dependent transport systems inner membrane component K02001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 384.0
TLS2_k127_3987905_6 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000001445 215.0
TLS2_k127_3987905_7 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000000000000000000000000004727 145.0
TLS2_k127_3997338_0 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 346.0
TLS2_k127_3997338_1 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001058 231.0
TLS2_k127_3997338_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000004993 196.0
TLS2_k127_3997338_3 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000001083 149.0
TLS2_k127_3997338_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000001881 98.0
TLS2_k127_3997338_5 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000002341 76.0
TLS2_k127_4010939_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004599 282.0
TLS2_k127_4011609_0 COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component K09014 - - 9.386e-233 728.0
TLS2_k127_4011609_1 RQC K03654 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 522.0
TLS2_k127_4011609_2 COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 339.0
TLS2_k127_4011609_3 Uncharacterized protein family (UPF0051) K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008733 277.0
TLS2_k127_4011609_4 PFAM Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000264 263.0
TLS2_k127_4011609_5 DeoR-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000003611 159.0
TLS2_k127_4011609_6 Protein of unknown function (DUF454) K09790 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000004232 130.0
TLS2_k127_4044185_0 Acyl-CoA dehydrogenase, C-terminal domain K00248,K09478 - 1.3.8.1,1.3.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 533.0
TLS2_k127_4044185_1 MMPL family K07003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 552.0
TLS2_k127_4044185_2 Acyl-CoA dehydrogenase, C-terminal domain K06446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 392.0
TLS2_k127_4044185_3 PFAM TENA THI-4 PQQC family K03707 - 3.5.99.2 0.000000000000000000000000000000000000000000000000000000000000002618 224.0
TLS2_k127_4044185_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000185 198.0
TLS2_k127_4044185_5 Radical SAM - - - 0.00000000000000000000000000000000000000000000001731 184.0
TLS2_k127_4067976_0 PFAM Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 608.0
TLS2_k127_4067976_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 303.0
TLS2_k127_4067976_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000001774 216.0
TLS2_k127_4067976_3 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000002176 200.0
TLS2_k127_4067976_4 Cytochrome c K02275,K17223 - 1.9.3.1 0.000001693 57.0
TLS2_k127_407595_0 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 537.0
TLS2_k127_407595_1 Esterase-like activity of phytase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 342.0
TLS2_k127_407595_2 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 308.0
TLS2_k127_407595_3 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000000002033 192.0
TLS2_k127_407595_4 UPF0060 membrane protein K09771 - - 0.00000000000000000000000000000000000000000005726 162.0
TLS2_k127_4101594_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K17228 - 1.14.14.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 477.0
TLS2_k127_4101594_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000007999 258.0
TLS2_k127_4101594_2 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.000000000000000000001202 108.0
TLS2_k127_4101594_3 ROS/MUCR transcriptional regulator protein - - - 0.0000000000000007673 84.0
TLS2_k127_4101594_4 Universal stress protein family - - - 0.00000002416 63.0
TLS2_k127_4101594_5 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.000122 53.0
TLS2_k127_4106683_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.561e-264 835.0
TLS2_k127_4106683_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 397.0
TLS2_k127_4106683_2 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000001084 244.0
TLS2_k127_4106683_3 Acyl-CoA dehydrogenase, N-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000003866 223.0
TLS2_k127_4106683_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000006941 95.0
TLS2_k127_4106683_5 NAD dependent epimerase/dehydratase family K00034 - 1.1.1.47 0.0000000000007093 69.0
TLS2_k127_4107266_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 423.0
TLS2_k127_4107266_1 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007811 399.0
TLS2_k127_4107266_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000009594 99.0
TLS2_k127_4107301_0 peptidase dimerisation domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 354.0
TLS2_k127_4107301_1 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000005079 225.0
TLS2_k127_4107301_2 glycosyl transferase group 1 - - - 0.0005061 44.0
TLS2_k127_4109060_0 Gaf domain - - - 1.155e-213 690.0
TLS2_k127_4109060_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 450.0
TLS2_k127_4109060_2 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 413.0
TLS2_k127_4109060_3 Belongs to the thiolase family K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 385.0
TLS2_k127_4109060_4 Periplasmic binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001611 231.0
TLS2_k127_4109060_5 AI-2E family transporter K11744 - - 0.0000000000000000000000000000000000000000000000000000000000005517 223.0
TLS2_k127_4109060_6 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000001796 166.0
TLS2_k127_4114713_0 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 357.0
TLS2_k127_4114713_1 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 286.0
TLS2_k127_4114713_2 Belongs to the LarC family K09121 - 4.99.1.12 0.00000000000000000000000000000000000002808 155.0
TLS2_k127_4117346_0 Belongs to the carbamoyltransferase HypF family K04656 - - 1.01e-256 812.0
TLS2_k127_4117346_1 hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009816 577.0
TLS2_k127_4117346_2 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 430.0
TLS2_k127_4117346_3 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000001112 166.0
TLS2_k127_4117346_4 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.00000000000000000007224 93.0
TLS2_k127_4131688_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 612.0
TLS2_k127_4131688_1 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001094 267.0
TLS2_k127_4131688_2 Pfam Amidohydrolase - - - 0.00000000000000000000000000000000000000000000407 179.0
TLS2_k127_4131688_3 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483,K16901,K21184,K21726 - 1.14.13.166,1.14.13.29,1.14.14.15,1.14.14.8,1.14.14.9 0.0000000000000000000000000000000000000000002986 162.0
TLS2_k127_4131688_4 serine-type endopeptidase activity - - - 0.000000000000201 70.0
TLS2_k127_4133698_0 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000486 258.0
TLS2_k127_4133698_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000003064 224.0
TLS2_k127_4133698_2 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000009594 99.0
TLS2_k127_4133698_3 - - - - 0.0000002642 58.0
TLS2_k127_4147728_0 Acetyl-CoA acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 434.0
TLS2_k127_4147728_1 His Kinase A (phosphoacceptor) domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001926 273.0
TLS2_k127_4147728_2 Flavin reductase like domain - - - 0.0000000000000000000000000000000000000000000000000000001311 199.0
TLS2_k127_4147728_3 Beta-lactamase-like protein 2 - GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0031974,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000002351 157.0
TLS2_k127_4147728_4 retrograde transport, endosome to Golgi K07095 - - 0.0000000000000000000000000000000000003117 147.0
TLS2_k127_4147728_5 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.000000000000000000000000000000004035 133.0
TLS2_k127_4147728_6 Epimerase dehydratase K01784,K17947 - 5.1.3.2,5.1.3.25 0.000000000000004636 86.0
TLS2_k127_4154667_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 1.373e-251 786.0
TLS2_k127_4154667_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 429.0
TLS2_k127_4154667_2 N-acetylglucosaminylinositol deacetylase activity K18455 - 3.5.1.115 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 301.0
TLS2_k127_4154667_3 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006379 269.0
TLS2_k127_4154667_4 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000006628 197.0
TLS2_k127_4154667_5 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000000001047 138.0
TLS2_k127_4154667_6 OmpA family - - - 0.000000000000000000000001267 108.0
TLS2_k127_416507_0 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 1.84e-225 711.0
TLS2_k127_416507_1 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.0000000000000000000000000000001438 134.0
TLS2_k127_416507_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000003396 95.0
TLS2_k127_416507_3 TIGRFAM acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000002238 65.0
TLS2_k127_4180836_0 Short-chain dehydrogenase reductase (SDR) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 346.0
TLS2_k127_4180836_1 Protein of unknown function (DUF3750) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004797 280.0
TLS2_k127_4180836_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059,K21883 - 1.1.1.100,1.1.1.401 0.00000000000000000000000000000000000000000000000853 179.0
TLS2_k127_4180836_3 AraC-like ligand binding domain - - - 0.00000000000000138 76.0
TLS2_k127_4180836_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000006606 64.0
TLS2_k127_4188482_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 549.0
TLS2_k127_4188482_1 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 499.0
TLS2_k127_4188482_2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 377.0
TLS2_k127_4188482_3 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000001967 123.0
TLS2_k127_4188482_4 Putative zinc- or iron-chelating domain - - - 0.0000000000000000000002163 104.0
TLS2_k127_4188482_5 Endonuclease exonuclease phosphatase family - - - 0.000000000000002017 88.0
TLS2_k127_4188482_6 PFAM PHP domain - - - 0.00000000000003595 82.0
TLS2_k127_4188482_8 Glutaredoxin - - - 0.000000000004695 67.0
TLS2_k127_4188482_9 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity K03763 - 2.7.7.7 0.00000000008842 69.0
TLS2_k127_4203047_0 Belongs to the TPP enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 554.0
TLS2_k127_4203047_1 PFAM Vitamin K-dependent gamma-carboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 456.0
TLS2_k127_4203047_2 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001082 246.0
TLS2_k127_4203047_3 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.0000000000000000000000000000000000000001151 159.0
TLS2_k127_4208993_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 4.718e-215 683.0
TLS2_k127_4208993_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - - 1.762e-194 614.0
TLS2_k127_4208993_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000001691 160.0
TLS2_k127_4208993_3 PspC domain protein K03973 - - 0.0000000000000000000000000000000000549 138.0
TLS2_k127_4208993_4 FxsA cytoplasmic membrane protein K07113 - - 0.000000000000000000000000000001606 125.0
TLS2_k127_4208993_5 Tetratricopeptide repeat - - - 0.0000000002953 68.0
TLS2_k127_4208993_6 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000001859 62.0
TLS2_k127_4217041_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 528.0
TLS2_k127_4217041_1 tRNA modification K06968 - 2.1.1.186 0.00000000000000000000000000000000000000000000000000000000000001082 220.0
TLS2_k127_4217041_2 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.00001183 49.0
TLS2_k127_4217041_3 Phosphoribosyl transferase domain K07100 - - 0.00004934 48.0
TLS2_k127_4219117_0 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001015 271.0
TLS2_k127_4219117_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000001819 231.0
TLS2_k127_4234786_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 372.0
TLS2_k127_4234786_1 peptidoglycan turnover K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.000000000000000000000000000000000000000000078 173.0
TLS2_k127_4234786_2 PFAM nuclease (SNase domain protein) - - - 0.0000000000000000000000008018 111.0
TLS2_k127_4244182_0 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 4.602e-255 798.0
TLS2_k127_4244182_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 294.0
TLS2_k127_4244182_2 Peptidase dimerisation domain K01436 - - 0.000000004826 59.0
TLS2_k127_4262195_0 HAMP domain K02482 - 2.7.13.3 0.00000000000000000000000000000000001035 149.0
TLS2_k127_4262195_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000003387 134.0
TLS2_k127_4262195_2 Antibiotic biosynthesis monooxygenase - - - 0.00000000002079 68.0
TLS2_k127_4262195_3 Ferritin, Dps family protein K03594 - 1.16.3.1 0.00000001433 58.0
TLS2_k127_4262195_4 Acid phosphatase homologues - - - 0.00005465 50.0
TLS2_k127_4269053_0 PFAM ABC transporter related K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 562.0
TLS2_k127_4269053_1 PFAM basic membrane lipoprotein K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 334.0
TLS2_k127_4269053_2 PFAM Transposase IS200 like - - - 0.0000000000000000000000000007638 112.0
TLS2_k127_4276850_0 AcrB/AcrD/AcrF family K03296 - - 5.073e-243 786.0
TLS2_k127_4276850_1 ABC-type multidrug transport system ATPase and permease K11085 - - 1.448e-215 686.0
TLS2_k127_4276850_2 Mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001255 274.0
TLS2_k127_4276850_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000002491 201.0
TLS2_k127_4285615_0 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008889 538.0
TLS2_k127_4285615_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002081 262.0
TLS2_k127_4285615_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000004445 66.0
TLS2_k127_4286850_0 Oxygen tolerance - - - 0.000000000000000000000000000000000000000000000000000000000000004998 240.0
TLS2_k127_4286850_1 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000008879 200.0
TLS2_k127_4286850_2 Phage Tail Collar Domain - - - 0.000000000000000000000000000000000000000000000000000114 191.0
TLS2_k127_4286850_3 Tail Collar - - - 0.00000000000000000000000000000000000000000000000005575 184.0
TLS2_k127_4286850_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000006758 182.0
TLS2_k127_4286850_5 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000003373 128.0
TLS2_k127_4286850_6 - - - - 0.000000000007444 70.0
TLS2_k127_4286850_7 chlorophyll binding K02519,K04043,K07114,K07288 - - 0.0005807 50.0
TLS2_k127_4309768_0 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 428.0
TLS2_k127_4309768_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.00000000000335 67.0
TLS2_k127_4309768_2 - - - - 0.000000003071 65.0
TLS2_k127_4315555_0 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000001722 123.0
TLS2_k127_4315555_1 Evidence 5 No homology to any previously reported sequences K03765 - - 0.000000000000001712 91.0
TLS2_k127_4315555_2 - - - - 0.0000000002481 73.0
TLS2_k127_4317029_0 Ribosomal protein S1 K02945,K03527,K07571 - 1.17.7.4 3.102e-221 702.0
TLS2_k127_4317029_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000001745 247.0
TLS2_k127_4317029_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000003168 237.0
TLS2_k127_4317029_3 cytidylate kinase activity K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000025 184.0
TLS2_k127_4317029_4 regulation of translation K05788 - - 0.000000000000000000000000000000000003874 139.0
TLS2_k127_4317029_5 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.000000000000000000000000001891 114.0
TLS2_k127_4317029_6 PFAM binding-protein-dependent transport systems inner membrane component K02034,K12370,K15582 - - 0.0005787 45.0
TLS2_k127_4318722_0 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 4.446e-234 736.0
TLS2_k127_4318722_1 Belongs to the D-glutamate cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005114 383.0
TLS2_k127_4318722_2 PFAM Rhomboid family K07059 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001472 252.0
TLS2_k127_4318722_3 kinase activity - - - 0.0000000000000000000000000000000000000000000000000000002303 206.0
TLS2_k127_4318722_4 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000001212 124.0
TLS2_k127_4318722_5 phosphoesterases, related to the Icc protein - - - 0.000000000000000000001687 106.0
TLS2_k127_4318722_6 Pfam Methyltransferase - - - 0.00000003565 57.0
TLS2_k127_4318722_7 Acetyltransferase (GNAT) domain - - - 0.0000005964 60.0
TLS2_k127_4318722_8 TatD related DNase K03424 - - 0.00005736 46.0
TLS2_k127_4318722_9 - - - - 0.0002211 53.0
TLS2_k127_4337728_0 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 382.0
TLS2_k127_4337728_1 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 373.0
TLS2_k127_4337728_2 transport systems K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 356.0
TLS2_k127_4337728_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 309.0
TLS2_k127_4337728_4 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000000000008962 185.0
TLS2_k127_4337728_5 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000006682 146.0
TLS2_k127_4338023_0 Helicase conserved C-terminal domain K10843 - 3.6.4.12 2.386e-213 676.0
TLS2_k127_4338023_1 Group II intron, maturase-specific domain K00986 - 2.7.7.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 581.0
TLS2_k127_4338023_3 DNA photolyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008637 292.0
TLS2_k127_4338023_4 helicase superfamily c-terminal domain - - - 0.00000000000001576 74.0
TLS2_k127_4338023_5 PFAM IS1 transposase - - - 0.0000000000006809 79.0
TLS2_k127_4338023_6 transposase activity - - - 0.0000000000007804 73.0
TLS2_k127_4338023_7 Helicase conserved C-terminal domain - - - 0.0000000007788 72.0
TLS2_k127_4338023_8 oxidoreductase activity - - - 0.0000004166 57.0
TLS2_k127_4338023_9 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.000001289 51.0
TLS2_k127_4347057_0 Belongs to the peptidase S16 family K01338,K04076,K04770 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007154 618.0
TLS2_k127_4347057_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 376.0
TLS2_k127_4347057_2 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000004246 248.0
TLS2_k127_4347057_3 protein transport across the cell outer membrane K02246,K08084 - - 0.0000000006369 67.0
TLS2_k127_435097_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1274.0
TLS2_k127_435097_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000000007915 154.0
TLS2_k127_435097_2 Thioredoxin-like - - - 0.0000000000000000000004243 101.0
TLS2_k127_4353123_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 1.054e-258 815.0
TLS2_k127_4353123_1 Poly A polymerase head domain K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000001322 226.0
TLS2_k127_4353123_2 Protein of unknown function (DUF2851) - - - 0.0000000000000000000000000000000000000000000000000000000000002164 231.0
TLS2_k127_4353123_3 Tetratricopeptide repeat - - - 0.0000007664 57.0
TLS2_k127_437818_0 GTP-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008695 334.0
TLS2_k127_437818_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002232 275.0
TLS2_k127_437818_2 Protein of unknown function (DUF2868) - - - 0.000000000000000000000000000003043 133.0
TLS2_k127_4452770_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 534.0
TLS2_k127_4452770_1 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001854 273.0
TLS2_k127_4452770_2 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685,K07053 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3,3.1.3.97 0.00000000000000000000000000000000000000000000000000001247 199.0
TLS2_k127_4452770_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000008277 130.0
TLS2_k127_4452770_4 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000107 108.0
TLS2_k127_4452770_5 Acyl transferase domain K00645 - 2.3.1.39 0.000000000000000003523 87.0
TLS2_k127_4481705_0 Belongs to the enoyl-CoA hydratase isomerase family K07546 - - 0.000000000000000000000000000000000000000000000000000131 195.0
TLS2_k127_4481705_1 amine dehydrogenase activity - - - 0.0000000000008981 78.0
TLS2_k127_449117_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 0.0 1220.0
TLS2_k127_449117_1 Metallophosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 419.0
TLS2_k127_449117_10 ABC-2 family transporter protein K01992 - - 0.000000000000000001844 89.0
TLS2_k127_449117_11 Acetyltransferase (GNAT) domain - - - 0.00000000000000009178 84.0
TLS2_k127_449117_12 ATPase activity K01990 - - 0.000000000001191 69.0
TLS2_k127_449117_13 Alpha amylase catalytic K05343 - 3.2.1.1,5.4.99.16 0.00000000001841 73.0
TLS2_k127_449117_15 Family of unknown function (DUF5335) - - - 0.00000005661 60.0
TLS2_k127_449117_16 - - - - 0.0000003592 53.0
TLS2_k127_449117_2 - - - - 0.0000000000000000000000000000000000000000000000000003144 194.0
TLS2_k127_449117_3 translation release factor activity K03265 - - 0.000000000000000000000000000000000000000000000006389 186.0
TLS2_k127_449117_4 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000002005 166.0
TLS2_k127_449117_5 UPF0060 membrane protein K09771 - - 0.000000000000000000000000000000000000000002544 157.0
TLS2_k127_449117_6 COGs COG2402 nucleic acid-binding protein contains PIN domain - - - 0.0000000000000000000000000000000000000001682 155.0
TLS2_k127_449117_7 CDP-archaeol synthase K19664 - 2.7.7.67 0.0000000000000000000000000000000000000005926 154.0
TLS2_k127_449117_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000905 128.0
TLS2_k127_449117_9 GAF domain - - - 0.00000000000000000000005898 101.0
TLS2_k127_4505878_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 315.0
TLS2_k127_4505878_1 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001504 259.0
TLS2_k127_4505878_2 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.000000000000000000000000000000000000000000000000002216 196.0
TLS2_k127_4505878_3 Protein of unknown function (DUF3568) - - - 0.000001045 55.0
TLS2_k127_4508493_0 Sterol carrier protein domain - - - 0.000000000000000000000000000000000000000000000000000000003226 211.0
TLS2_k127_4508493_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000007323 205.0
TLS2_k127_4544216_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.525e-224 722.0
TLS2_k127_4544216_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.761e-212 675.0
TLS2_k127_4544216_2 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002916 384.0
TLS2_k127_4544216_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000007072 174.0
TLS2_k127_4544216_4 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000009646 90.0
TLS2_k127_455338_0 nitrite reductase (NAD(P)H) large subunit - - - 0.0 1442.0
TLS2_k127_455338_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.0 1061.0
TLS2_k127_455338_2 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 2.691e-219 690.0
TLS2_k127_455338_3 Major Facilitator Superfamily K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 607.0
TLS2_k127_455338_4 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 569.0
TLS2_k127_455338_5 Acetyl xylan esterase (AXE1) K06889,K07397 - - 0.00000000000000000000000000000000000000000000000000000000005323 213.0
TLS2_k127_455338_6 - - - - 0.0000000000000000000000000000000000001637 152.0
TLS2_k127_4577541_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 4.085e-293 912.0
TLS2_k127_4577541_1 GIY-YIG type nucleases (URI domain) K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 575.0
TLS2_k127_4577541_2 FAD linked oxidases, C-terminal domain K00102,K00104 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 1.1.2.4,1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 303.0
TLS2_k127_4577541_3 Putative peptidoglycan binding domain - - - 0.0000000000000000000000000000000000000000004899 163.0
TLS2_k127_4577541_4 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000000000002461 161.0
TLS2_k127_4579110_0 Glycosyl hydrolases family 15 - - - 2.508e-286 890.0
TLS2_k127_4579110_1 PFAM Resolvase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002119 265.0
TLS2_k127_4579110_2 Pfam Amidohydrolase - - - 0.0004335 47.0
TLS2_k127_4585066_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000001796 254.0
TLS2_k127_4585066_1 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000295 214.0
TLS2_k127_4585066_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000007155 134.0
TLS2_k127_4585066_3 LVIVD repeat - - - 0.0000000000000000000000000009502 116.0
TLS2_k127_4585066_4 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000005769 79.0
TLS2_k127_458745_0 Beta-eliminating lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006112 291.0
TLS2_k127_458745_1 phosphogluconate dehydrogenase (decarboxylating) activity K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006937 280.0
TLS2_k127_458745_2 cellulose binding - - - 0.00000000000000000000000000000000000000000000000002627 193.0
TLS2_k127_4613846_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972,K02342,K04096,K12472 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 2.7.7.7,6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 435.0
TLS2_k127_4613846_1 Lysine methyltransferase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009892,GO:0009894,GO:0009895,GO:0009987,GO:0010565,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018023,GO:0018193,GO:0018205,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0031974,GO:0031998,GO:0031999,GO:0032259,GO:0036211,GO:0043086,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043467,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045833,GO:0045922,GO:0046320,GO:0046322,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050994,GO:0050995,GO:0051341,GO:0051354,GO:0062012,GO:0062014,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1904732,GO:1904733,GO:1904735,GO:1904736 - 0.000000000000000000000006132 108.0
TLS2_k127_461385_0 Glucose-6-phosphate dehydrogenase, NAD binding domain K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 616.0
TLS2_k127_461385_1 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 475.0
TLS2_k127_461385_2 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.0000000000000000000000001151 108.0
TLS2_k127_461385_3 Protein of unknown function (DUF4243) - - - 0.000000003148 62.0
TLS2_k127_4644379_0 catalase activity K03781 - 1.11.1.6 1.454e-263 817.0
TLS2_k127_4644379_1 LysR substrate binding domain K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007935 309.0
TLS2_k127_4644379_2 COG0668 Small-conductance mechanosensitive channel - - - 0.0000000000000000000000000000002084 131.0
TLS2_k127_4644379_3 PFAM GDSL-like Lipase Acylhydrolase - - - 0.0000000000000000000000004866 105.0
TLS2_k127_4675044_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 298.0
TLS2_k127_4675044_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000004996 202.0
TLS2_k127_4685644_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 387.0
TLS2_k127_4685644_1 PFAM Alcohol dehydrogenase zinc-binding domain protein K19745 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005801 379.0
TLS2_k127_4685644_2 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000001224 229.0
TLS2_k127_4685644_3 4Fe-4S binding domain K05524 - - 0.0000000000000000000000000000209 121.0
TLS2_k127_4691641_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 526.0
TLS2_k127_4691641_1 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000001463 242.0
TLS2_k127_4691641_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000325 109.0
TLS2_k127_4692382_0 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 432.0
TLS2_k127_4692382_1 Acetyl-CoA acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 325.0
TLS2_k127_4692382_2 Caspase domain - - - 0.00000000000000000000000000000000000000000002091 164.0
TLS2_k127_4692382_3 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.00000000000000000000000000000002673 130.0
TLS2_k127_4692382_4 Pyridoxamine 5'-phosphate - - - 0.000000000001256 74.0
TLS2_k127_4692382_5 - - - - 0.000003657 55.0
TLS2_k127_4694392_0 SIR2-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 460.0
TLS2_k127_4694392_1 GMC oxidoreductase K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 398.0
TLS2_k127_4694392_2 SIR2-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 331.0
TLS2_k127_4694392_3 PFAM LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000002686 194.0
TLS2_k127_4694392_4 PAC2 family - - - 0.0000000000000000000000000000000000000000000000002728 187.0
TLS2_k127_4694392_5 - - - - 0.000000000000000000000000000000000000003825 147.0
TLS2_k127_4694392_6 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000005126 141.0
TLS2_k127_4694392_7 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.000000000000000000000000000000001519 142.0
TLS2_k127_4694392_8 Hydrogenase/urease nickel incorporation, metallochaperone, hypA - - - 0.000000000000000000000678 98.0
TLS2_k127_4694392_9 TPM domain K06872 - - 0.000000000000001401 84.0
TLS2_k127_4701677_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000002075 202.0
TLS2_k127_4701677_1 Ferric reductase NAD binding domain - - - 0.00000000000000000000000000000000669 133.0
TLS2_k127_4709865_0 PFAM IS1 transposase K07480 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001895 280.0
TLS2_k127_4709865_1 nitrite reductase [NAD(P)H] activity - - - 0.000000000000000000000000000000000000000005851 159.0
TLS2_k127_4709865_2 PIN domain - - - 0.00000000000000000000000000000000005734 138.0
TLS2_k127_4709865_3 positive regulation of growth - - - 0.0000000000000000001074 91.0
TLS2_k127_4709865_4 Transcriptional regulatory protein, C terminal - - - 0.00000000002657 69.0
TLS2_k127_4712484_0 ABC transporter - - - 1.41e-262 829.0
TLS2_k127_4712484_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585,K18306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 401.0
TLS2_k127_4712484_2 Lanthionine synthetase C-like protein K20484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003673 289.0
TLS2_k127_4712484_3 PFAM LmbE family protein - - - 0.00000000000000000000000000000000000000000000000007723 190.0
TLS2_k127_4712484_4 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000003625 162.0
TLS2_k127_4712484_5 Lantibiotic biosynthesis dehydratase C-term K20483 - - 0.000000000000000001114 89.0
TLS2_k127_4712484_7 PFAM transcriptional regulator domain protein - - - 0.00000000001954 67.0
TLS2_k127_4719308_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 2.612e-194 617.0
TLS2_k127_4719308_1 TonB C terminal K03832 - - 0.0000003018 56.0
TLS2_k127_4727838_0 membrane organization - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 379.0
TLS2_k127_4727838_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000009652 220.0
TLS2_k127_4727838_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.00000000000000000000000000000001087 130.0
TLS2_k127_472810_0 PFAM S-adenosylmethionine synthetase (MAT) K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007749 469.0
TLS2_k127_472810_1 C-terminal, D2-small domain, of ClpB protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 454.0
TLS2_k127_472810_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 329.0
TLS2_k127_472810_3 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000000000001576 166.0
TLS2_k127_472810_4 acetyltransferase - - - 0.00000000000000000000000000000000001285 150.0
TLS2_k127_4730553_0 Belongs to the GMC oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007901 392.0
TLS2_k127_4730553_1 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002797 282.0
TLS2_k127_4730553_2 Acetyltransferase (GNAT) domain K03817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005879 245.0
TLS2_k127_4730553_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000001196 85.0
TLS2_k127_4732888_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 2.431e-203 661.0
TLS2_k127_4732888_1 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 611.0
TLS2_k127_4732888_10 Carboxylesterase family - - - 0.0008077 46.0
TLS2_k127_4732888_2 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 469.0
TLS2_k127_4732888_3 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 321.0
TLS2_k127_4732888_4 PFAM PIN domain - - - 0.00000000000000000000000000000000000000000000008899 171.0
TLS2_k127_4732888_5 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000001448 154.0
TLS2_k127_4732888_6 Belongs to the ompA family K03286 - - 0.0000000000000000000000002265 113.0
TLS2_k127_4732888_7 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.0000000000000000000000002458 109.0
TLS2_k127_4732888_8 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.00000000000000000000001812 102.0
TLS2_k127_4732888_9 restriction endonuclease K07448 - - 0.000000001796 62.0
TLS2_k127_473972_0 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005883 279.0
TLS2_k127_473972_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004997 249.0
TLS2_k127_473972_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000006076 171.0
TLS2_k127_473972_3 Carbamoyltransferase C-terminus K00612 - - 0.000000000000000000000000000000000000000000006361 182.0
TLS2_k127_473972_4 rRNA (adenine-N6,N6-)-dimethyltransferase activity K00561,K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.184 0.00000000000000000000000000000000000000000001398 168.0
TLS2_k127_473972_5 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000001799 108.0
TLS2_k127_473972_7 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00002085 49.0
TLS2_k127_4743896_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 493.0
TLS2_k127_4743896_1 of the PP-loop superfamily K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 306.0
TLS2_k127_4745034_0 ATPase associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000751 453.0
TLS2_k127_4745034_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23,1.1.1.308 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 406.0
TLS2_k127_4745034_2 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 372.0
TLS2_k127_4745034_3 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 319.0
TLS2_k127_4745034_4 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 321.0
TLS2_k127_4745034_5 Domain of unknown function (DUF4175) - - - 0.0000000000000000000000000000000000000000000000001775 203.0
TLS2_k127_4745034_6 cobalamin binding K22491 - - 0.000000000000000000000000000002113 132.0
TLS2_k127_4745034_7 oxidoreductase activity K21000 - - 0.000000000004691 75.0
TLS2_k127_4763121_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 290.0
TLS2_k127_4763121_1 Tetratricopeptide repeat - - - 0.0000000004357 70.0
TLS2_k127_4763121_2 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000004356 61.0
TLS2_k127_4766166_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K19694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008395 377.0
TLS2_k127_4766166_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006481 304.0
TLS2_k127_4766166_2 PFAM Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000002411 187.0
TLS2_k127_4766166_3 anion transmembrane transporter activity K02045,K02049,K15555 - 3.6.3.25 0.000000000000000005498 98.0
TLS2_k127_4766361_0 56kDa selenium binding protein (SBP56) K17285 - - 2.224e-259 802.0
TLS2_k127_4766361_1 Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 421.0
TLS2_k127_4766361_2 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008283 369.0
TLS2_k127_4766361_3 Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003158 311.0
TLS2_k127_4766361_4 CoA-binding protein K06929 - - 0.000000000000000000000000000000000000000000000000000000000000000002063 229.0
TLS2_k127_4766361_5 Ferredoxin K02639 - - 0.000000000000000000000000000000000000000000000001844 176.0
TLS2_k127_4771796_0 helix_turn_helix, mercury resistance K22491 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004877 255.0
TLS2_k127_4771796_1 glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000006392 167.0
TLS2_k127_4773808_0 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008737 602.0
TLS2_k127_4773808_1 KR domain K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 313.0
TLS2_k127_4773808_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000002189 192.0
TLS2_k127_4773808_3 PFAM OmpA MotB domain protein K02557 - - 0.000000000000000000000000008004 127.0
TLS2_k127_4775164_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1097.0
TLS2_k127_4775164_1 Dihydroorotate dehydrogenase K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 363.0
TLS2_k127_4782379_0 peptidase dimerisation domain protein K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 461.0
TLS2_k127_4782379_1 peptidase dimerisation domain protein K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005164 418.0
TLS2_k127_4790525_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 460.0
TLS2_k127_4790525_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 431.0
TLS2_k127_4790525_2 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000003387 194.0
TLS2_k127_4790525_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000002603 63.0
TLS2_k127_4790636_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 481.0
TLS2_k127_4790636_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000116 122.0
TLS2_k127_4798964_0 AMP-binding enzyme K00666,K12423,K12426,K12428 - - 6.884e-312 982.0
TLS2_k127_4798964_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00003,K00982,K00990,K06950,K15371 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698 1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008591 567.0
TLS2_k127_4798964_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 432.0
TLS2_k127_4798964_3 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 379.0
TLS2_k127_4798964_4 [glutamate-ammonia-ligase] adenylyltransferase activity K00982 GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000611 334.0
TLS2_k127_4798964_5 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005159 263.0
TLS2_k127_4798964_6 MltA-interacting protein MipA - - - 0.000000000000000000000000000000000000000000000000000000000000000003694 237.0
TLS2_k127_4798964_7 - - - - 0.00000000000000000004371 95.0
TLS2_k127_4798964_8 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - 0.00000008617 57.0
TLS2_k127_4798964_9 PFAM MmgE PrpD family protein - - - 0.000006976 50.0
TLS2_k127_4799833_0 B12 binding domain - - - 6.276e-293 906.0
TLS2_k127_4799833_1 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 455.0
TLS2_k127_4799833_2 Endoribonuclease L-PSP K09021 - - 0.0000000000000000000000000000000000000003875 150.0
TLS2_k127_4799833_3 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.000000000000000000000000000000000000008502 165.0
TLS2_k127_4799833_4 peptide-methionine (R)-S-oxide reductase K07305 - 1.8.4.12 0.00000000009301 63.0
TLS2_k127_4801733_0 Fe-S oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003331 304.0
TLS2_k127_4801733_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000002153 144.0
TLS2_k127_4808687_0 Transglutaminase/protease-like homologues - - - 0.0 1502.0
TLS2_k127_4808687_1 Circularly permuted ATP-grasp type 2 - - - 4.021e-225 706.0
TLS2_k127_4808687_2 Circularly permuted ATP-grasp type 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 622.0
TLS2_k127_4808687_3 COG0380 Trehalose-6-phosphate synthase K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 435.0
TLS2_k127_4808687_4 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 404.0
TLS2_k127_4812412_0 Aminotransferase K11358 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 483.0
TLS2_k127_4812412_1 TIGRFAM glutamate synthases, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 397.0
TLS2_k127_482678_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 345.0
TLS2_k127_482678_1 Stage II sporulation E family protein - - - 0.00000000000000000000000000000000000000000000000366 191.0
TLS2_k127_482678_2 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000001756 60.0
TLS2_k127_4829880_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 365.0
TLS2_k127_4829880_1 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.00000000000000000000000000000000000000000000000000000005637 202.0
TLS2_k127_4829880_2 Dodecin K09165 - - 0.0000000000000000007119 88.0
TLS2_k127_4829880_3 AMP binding - - - 0.0000000000000001725 90.0
TLS2_k127_4829880_4 ThiS family K03154 - - 0.0000000000005034 71.0
TLS2_k127_4831620_0 MlrC C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005284 568.0
TLS2_k127_4831620_1 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488,K21053 - 3.5.4.2,3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007606 469.0
TLS2_k127_4831620_2 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 430.0
TLS2_k127_4831620_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000002723 229.0
TLS2_k127_4831620_4 NUDIX domain - - - 0.000000000000000000000000000000000000000000001103 172.0
TLS2_k127_4846215_0 Belongs to the argininosuccinate synthase family. Type K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 6.017e-212 669.0
TLS2_k127_4846215_1 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 469.0
TLS2_k127_4846215_2 Bifunctional purine biosynthesis protein PURH. Source PGD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 443.0
TLS2_k127_4846215_3 glutathionylspermidine amidase activity K01460 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464 3.5.1.78,6.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 385.0
TLS2_k127_4846215_4 PFAM zinc finger SWIM domain protein - - - 0.000000000000000000000006439 103.0
TLS2_k127_4850553_0 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 408.0
TLS2_k127_4850553_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000001807 213.0
TLS2_k127_4850553_2 Pyridoxamine 5'-phosphate oxidase like - - - 0.00000000000000000000000000000000000000001641 159.0
TLS2_k127_4850553_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000003735 64.0
TLS2_k127_4859407_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.041e-265 833.0
TLS2_k127_4859407_1 - - - - 0.00000000000000002864 83.0
TLS2_k127_4859407_2 Nitrile hydratase - - - 0.0009165 42.0
TLS2_k127_486688_0 GTP cyclohydrolase II - - - 3.282e-206 647.0
TLS2_k127_486688_1 diaminopimelate decarboxylase activity K01586,K12526 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4,4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 469.0
TLS2_k127_486688_2 Uracil phosphoribosyltransferase K00761 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000983 280.0
TLS2_k127_486688_3 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000001947 237.0
TLS2_k127_486688_4 YGGT family K02221 - - 0.0000000000000000000007917 105.0
TLS2_k127_4867335_0 PFAM Glycosyl transferases group 1 K00713,K06338 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006795 446.0
TLS2_k127_4867335_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004453 278.0
TLS2_k127_4867335_2 ABC-type multidrug transport system ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000000000000000005909 205.0
TLS2_k127_4867335_3 Glycosyl transferase, family 2 K00721,K07011,K20444 - 2.4.1.83 0.00000000000000000000000000001607 131.0
TLS2_k127_4867335_4 Methyltransferase domain - - - 0.000000000000185 82.0
TLS2_k127_4867566_0 thiolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 305.0
TLS2_k127_4867566_1 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000000000002043 129.0
TLS2_k127_4867566_2 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000002645 96.0
TLS2_k127_4867566_3 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0000000000000000005111 93.0
TLS2_k127_4870875_0 formate dehydrogenase (NAD+) activity K00336,K18006 - 1.12.1.2,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 454.0
TLS2_k127_4870875_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337,K05572 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 372.0
TLS2_k127_4870875_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000001496 142.0
TLS2_k127_4870875_3 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000002931 117.0
TLS2_k127_4870875_4 Adenylate cyclase - - - 0.0000000000000000000000000005924 119.0
TLS2_k127_4873275_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 486.0
TLS2_k127_4873275_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000009649 128.0
TLS2_k127_4873275_2 - - - - 0.0000001217 57.0
TLS2_k127_4883020_0 PFAM AMP-dependent synthetase and ligase K01895,K01896 - 6.2.1.1,6.2.1.2 1.199e-230 726.0
TLS2_k127_4883020_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 413.0
TLS2_k127_4883020_2 PFAM Transposase DDE domain K07495 - - 0.0000000002549 66.0
TLS2_k127_4883020_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0007844 42.0
TLS2_k127_4901668_0 DNA photolyase activity K03716 - 4.1.99.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 315.0
TLS2_k127_4901668_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 297.0
TLS2_k127_4901668_2 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000002386 224.0
TLS2_k127_4901668_3 TIGRFAM Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily - - - 0.0000000000000000000000000000000000000000001172 171.0
TLS2_k127_4901668_4 PFAM ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000004755 149.0
TLS2_k127_4901668_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342,K10857 - 2.7.7.7 0.0000000000000000000000000000000000114 147.0
TLS2_k127_4901668_7 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000004047 128.0
TLS2_k127_4901668_8 Belongs to the ParB family K03497 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - 0.0000003721 61.0
TLS2_k127_4901668_9 galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.0001923 53.0
TLS2_k127_4905799_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001621 276.0
TLS2_k127_4905799_1 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000000000000008582 233.0
TLS2_k127_4905799_2 Tetratricopeptide TPR_2 repeat protein - - - 0.0007949 52.0
TLS2_k127_4911794_0 transmembrane sensor domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 504.0
TLS2_k127_4911794_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K02573,K21566,K21647 - 1.21.99.5 0.0000000000000000000000000000000000000000000000000000000000002063 227.0
TLS2_k127_4911794_2 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000003006 183.0
TLS2_k127_4911794_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.000000000000000000000000002137 121.0
TLS2_k127_4911794_4 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000005084 112.0
TLS2_k127_4911794_5 PFAM Pentapeptide repeats (8 copies) - - - 0.00000000000000000006133 96.0
TLS2_k127_491435_0 Glycosyl hydrolases family 15 - - - 7.268e-281 874.0
TLS2_k127_491435_1 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000107 232.0
TLS2_k127_491435_2 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.0000000000000000000000007571 109.0
TLS2_k127_491435_3 SMART alpha amylase, catalytic sub domain K01187,K05343 - 3.2.1.1,3.2.1.20,5.4.99.16 0.00000000000000000000004324 106.0
TLS2_k127_491557_0 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 512.0
TLS2_k127_491557_1 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004434 434.0
TLS2_k127_491557_10 Peptidoglycan-binding domain-containing protein - - - 0.00000003749 63.0
TLS2_k127_491557_2 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 364.0
TLS2_k127_491557_3 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004982 275.0
TLS2_k127_491557_4 Aldo keto reductases, related to diketogulonate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000009355 231.0
TLS2_k127_491557_5 form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription K12410 - - 0.0000000000000000000000000000000000000000000000000000001006 205.0
TLS2_k127_491557_6 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000003521 188.0
TLS2_k127_491557_7 Protein of unknown function (DUF423) - - - 0.00000000000000000000000000002944 120.0
TLS2_k127_491557_8 OmpA family - - - 0.000000000000000000000005686 113.0
TLS2_k127_491557_9 SLBB domain K02237 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000001979 81.0
TLS2_k127_4929374_0 Flavin containing amine oxidoreductase - - - 2.752e-209 661.0
TLS2_k127_4929374_1 Pyruvate ferredoxin oxidoreductase and related K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000491 488.0
TLS2_k127_4929374_2 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 485.0
TLS2_k127_4929374_3 aconitate hydratase K01681 - 4.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 301.0
TLS2_k127_4929374_4 KR domain K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 297.0
TLS2_k127_4929374_5 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 301.0
TLS2_k127_4929374_6 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000001579 172.0
TLS2_k127_4962426_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 8.97e-222 697.0
TLS2_k127_4962426_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 6.9e-216 679.0
TLS2_k127_4962426_10 N-ATPase, AtpR subunit - - - 0.000000000000000000002624 96.0
TLS2_k127_4962426_11 Universal stress protein - - - 0.000000000005747 72.0
TLS2_k127_4962426_2 ATP synthase A chain K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000742 324.0
TLS2_k127_4962426_3 IS1 transposase K07480 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 313.0
TLS2_k127_4962426_4 ATP synthase K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001052 286.0
TLS2_k127_4962426_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000007973 178.0
TLS2_k127_4962426_6 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.0000000000000000000000000000000000000000004511 162.0
TLS2_k127_4962426_7 Universal stress protein - - - 0.00000000000000000000000000000000000000008594 164.0
TLS2_k127_4962426_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000000000001205 150.0
TLS2_k127_4962426_9 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000000000000000000000000000007297 130.0
TLS2_k127_4965369_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 361.0
TLS2_k127_4965369_1 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000006931 192.0
TLS2_k127_4965369_2 2Fe-2S -binding domain K03518,K18022 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051537,GO:0051540,GO:0055114 1.2.5.3,1.2.99.8 0.00000000000000000000000000000000000000000000000006677 183.0
TLS2_k127_4965369_3 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000261 96.0
TLS2_k127_4965786_0 Dehydratase family K22186 - 4.2.1.82 2.062e-215 679.0
TLS2_k127_4965786_1 COG0044 Dihydroorotase and related cyclic amidohydrolases - - - 1.264e-195 621.0
TLS2_k127_4965786_2 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 303.0
TLS2_k127_4965786_3 cobalamin synthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006825 282.0
TLS2_k127_4965786_5 - - - - 0.00000000000000001642 85.0
TLS2_k127_4968905_0 PFAM Prenyltransferase squalene oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000205 241.0
TLS2_k127_4968905_1 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000001923 162.0
TLS2_k127_4968905_2 von Willebrand factor (vWF) type A domain - - - 0.0000000000008036 79.0
TLS2_k127_4972442_0 Sulfite reductase K00366,K00381,K00392 - 1.7.7.1,1.8.1.2,1.8.7.1 1.096e-309 966.0
TLS2_k127_4972442_1 Memo-like protein K06990 - - 0.0000000000000000000000001432 114.0
TLS2_k127_4972442_2 - - - - 0.0000000000000000000000003082 118.0
TLS2_k127_4973313_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000002345 213.0
TLS2_k127_4973313_1 PFAM NHL repeat - - - 0.00000000000000000000000000000000000000000000003902 176.0
TLS2_k127_4973313_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000003453 160.0
TLS2_k127_4973313_3 LysE type translocator - - - 0.000000000000000000000000000000000000000003671 163.0
TLS2_k127_4973313_4 Belongs to the Nudix hydrolase family. NudJ subfamily K03574,K12152 GO:0003674,GO:0003824,GO:0004787,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0017111 3.6.1.55 0.00000000000000000002849 96.0
TLS2_k127_4973313_5 - - - - 0.000000000000000001592 90.0
TLS2_k127_4975141_0 Proton-conducting membrane transporter K00342 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 1.621e-207 657.0
TLS2_k127_4975141_1 COG3119 Arylsulfatase A and related enzymes K01130 - 3.1.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 606.0
TLS2_k127_4975141_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 512.0
TLS2_k127_4975141_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 290.0
TLS2_k127_4980597_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004169 261.0
TLS2_k127_4980597_1 PFAM NHL repeat containing protein - - - 0.000000000000000000000000000000000000000000000000001036 194.0
TLS2_k127_4981362_0 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000471 209.0
TLS2_k127_4981362_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000004619 164.0
TLS2_k127_4981362_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000106 155.0
TLS2_k127_4981362_3 cheY-homologous receiver domain - - - 0.00000000000000000000000005211 111.0
TLS2_k127_4981362_4 Conserved TM helix - - - 0.0000000002243 71.0
TLS2_k127_4991707_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K00806,K15888 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000006518 269.0
TLS2_k127_4991707_1 Wd40 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007386 271.0
TLS2_k127_4991707_2 Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.0000000000000000000001849 110.0
TLS2_k127_5008511_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 7.727e-307 961.0
TLS2_k127_5008511_1 ATPase family associated with various cellular activities (AAA) K07478 - - 1.165e-276 869.0
TLS2_k127_5008511_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.968e-240 764.0
TLS2_k127_5008511_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 304.0
TLS2_k127_5008511_4 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002853 276.0
TLS2_k127_5008511_5 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02031,K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001832 266.0
TLS2_k127_5008511_6 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001582 256.0
TLS2_k127_5008511_7 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000001838 209.0
TLS2_k127_5008511_8 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000006812 175.0
TLS2_k127_5008511_9 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.000000000005559 71.0
TLS2_k127_5011323_0 peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 341.0
TLS2_k127_5011323_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 301.0
TLS2_k127_5011323_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000001015 206.0
TLS2_k127_5011323_3 It is involved in the biological process described with DNA repair K20813 GO:0000122,GO:0000166,GO:0000287,GO:0000700,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003712,GO:0003824,GO:0004844,GO:0005080,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005886,GO:0006139,GO:0006220,GO:0006244,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006298,GO:0006304,GO:0006355,GO:0006357,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008263,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0017076,GO:0018130,GO:0019104,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0030554,GO:0030983,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031402,GO:0031404,GO:0031420,GO:0031974,GO:0031981,GO:0032091,GO:0032182,GO:0032183,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035510,GO:0035511,GO:0035561,GO:0035562,GO:0035639,GO:0036094,GO:0040029,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043393,GO:0043412,GO:0043621,GO:0043739,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0044728,GO:0045008,GO:0045892,GO:0045934,GO:0045995,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051098,GO:0051100,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0051336,GO:0051716,GO:0055086,GO:0055114,GO:0060255,GO:0065007,GO:0065009,GO:0070013,GO:0070988,GO:0070989,GO:0071704,GO:0071944,GO:0072527,GO:0072529,GO:0080090,GO:0080111,GO:0090304,GO:0097159,GO:0097367,GO:0097506,GO:0140097,GO:0140110,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1902544,GO:1902679,GO:1903506,GO:1903507,GO:2000026,GO:2000112,GO:2000113,GO:2001141 3.2.2.29 0.000000000000000000000000000000000000001628 154.0
TLS2_k127_5014920_0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005877 284.0
TLS2_k127_5014920_1 CoA-transferase family III K07544,K07749 - 2.8.3.15,2.8.3.16 0.0000000000000000000001419 102.0
TLS2_k127_5014920_2 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749,K18702 - 2.8.3.16,2.8.3.19 0.000005798 51.0
TLS2_k127_5019693_0 formamidase K01455 - 3.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 439.0
TLS2_k127_5019693_1 TIGRFAM nitrile hydratase, alpha subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003907 280.0
TLS2_k127_5019693_2 Belongs to the hyi family K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000286 278.0
TLS2_k127_5019693_3 Nitrile hydratase beta subunit - - - 0.0000000000000000000000000000000000000000000000001095 185.0
TLS2_k127_5019693_4 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000002241 122.0
TLS2_k127_5019693_5 Nitrile hydratase beta subunit - - - 0.0000000000000000008093 90.0
TLS2_k127_5019693_6 hydrolase activity - GO:0008150,GO:0050789,GO:0050794,GO:0051726,GO:0065007 - 0.0000000000000009066 80.0
TLS2_k127_5025963_0 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000493 374.0
TLS2_k127_5025963_1 electron transfer flavoprotein K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0016628,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.3.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000206 287.0
TLS2_k127_5025963_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000143 246.0
TLS2_k127_5025963_3 PFAM Electron transfer flavoprotein alpha beta-subunit K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000004124 232.0
TLS2_k127_5025963_4 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000583 196.0
TLS2_k127_5025963_5 response to drug K03748 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0042221,GO:0042493,GO:0044425,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000004231 198.0
TLS2_k127_5025963_6 PFAM thioesterase superfamily - - - 0.00000000000000000000000001147 113.0
TLS2_k127_5026455_0 Belongs to the ClpA ClpB family K03694 - - 2.869e-230 726.0
TLS2_k127_5026455_1 Yqey-like protein K09117 - - 0.000000000000000000000000000000000004345 141.0
TLS2_k127_5026455_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000008676 129.0
TLS2_k127_5026455_3 Glyoxalase-like domain K08234 - - 0.00000000000000001537 88.0
TLS2_k127_5026455_4 Nitroreductase family - - - 0.0001133 44.0
TLS2_k127_5027185_0 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 473.0
TLS2_k127_5027185_1 acid transport system permease K09970 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 409.0
TLS2_k127_5027185_2 sensor histidine kinase - - - 0.000000000002494 76.0
TLS2_k127_5029735_0 short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003046 257.0
TLS2_k127_5029735_1 COG0655 Multimeric flavodoxin WrbA - - - 0.00000000000000000000000000000000000000000000000000000000008512 207.0
TLS2_k127_5029735_2 Acyl-CoA dehydrogenase, middle domain K00249 - 1.3.8.7 0.000000000000000000000000000000000375 136.0
TLS2_k127_5029735_3 Belongs to the Fur family K03711 - - 0.0000000000000000000000000003175 125.0
TLS2_k127_5039633_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006028 474.0
TLS2_k127_5039633_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 323.0
TLS2_k127_5039633_2 4Fe-4S single cluster domain K05337 - - 0.00000000021 63.0
TLS2_k127_5047006_0 COG3256 Nitric oxide reductase large subunit K04561 - 1.7.2.5 1.429e-275 854.0
TLS2_k127_5047006_1 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 300.0
TLS2_k127_5047006_2 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008767 273.0
TLS2_k127_5047006_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000001261 222.0
TLS2_k127_5047006_4 Enoyl-CoA hydratase carnithine racemase - - - 0.0000000000000000000000000000000000000003004 158.0
TLS2_k127_5047006_5 Calx-beta domain K01406,K20444 - 3.4.24.40 0.000000000000000000000000001544 130.0
TLS2_k127_5047006_6 - - - - 0.00000000000000000000000005606 109.0
TLS2_k127_5049422_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 437.0
TLS2_k127_5049422_1 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000002599 155.0
TLS2_k127_5049422_2 Rdx family K07401 - - 0.000000000000000000000000000000000001404 140.0
TLS2_k127_5049422_3 racemase K16841 - 5.1.99.3 0.00000000000000000000000000000008641 134.0
TLS2_k127_5049422_4 Autotransporter beta-domain - - - 0.0000000005706 65.0
TLS2_k127_5058411_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 1.944e-205 661.0
TLS2_k127_5058411_1 Sulfate permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 474.0
TLS2_k127_5058411_2 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004527 363.0
TLS2_k127_5058411_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000001996 74.0
TLS2_k127_5058588_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - 2.941e-248 789.0
TLS2_k127_5058588_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.287e-199 638.0
TLS2_k127_5058588_2 hemolysin activation secretion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 445.0
TLS2_k127_5058588_3 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 316.0
TLS2_k127_5058588_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000003246 62.0
TLS2_k127_508162_0 Uncharacterized BCR, YaiI/YqxD family COG1671 K09768 - - 0.0000000000000000000000000000000000000000000005896 170.0
TLS2_k127_508162_1 Cupin domain - - - 0.0000000000000000000000001621 109.0
TLS2_k127_508162_2 Ring hydroxylating beta subunit K15750 - 1.14.12.18 0.00000000000000000009182 89.0
TLS2_k127_508162_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000000795 87.0
TLS2_k127_508162_4 - - - - 0.0000000007791 61.0
TLS2_k127_5083055_0 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 535.0
TLS2_k127_5083055_1 cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000001138 245.0
TLS2_k127_5083055_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 0.00000000000000000000000000000003373 128.0
TLS2_k127_5083055_3 Cell division protein FtsQ K03589 - - 0.0000000007604 69.0
TLS2_k127_5084699_0 TrkA-C domain - - - 5.71e-220 697.0
TLS2_k127_5084699_1 Fumarase C-terminus K01676 - 4.2.1.2 1.801e-219 687.0
TLS2_k127_5084699_2 PFAM Taurine catabolism dioxygenase TauD TfdA K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 315.0
TLS2_k127_5084699_3 PFAM transposase, IS4 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 301.0
TLS2_k127_5084699_4 Polysaccharide deacetylase - - - 0.00000000000008792 76.0
TLS2_k127_5090201_0 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 501.0
TLS2_k127_5090201_1 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 314.0
TLS2_k127_5090201_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000003724 111.0
TLS2_k127_5090201_3 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000004235 57.0
TLS2_k127_5095403_0 Ring hydroxylating alpha subunit (catalytic domain) K16319,K18074 - 1.14.12.1,1.14.12.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 508.0
TLS2_k127_5095403_1 Binding-protein-dependent transport system inner membrane component K11070,K11074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 415.0
TLS2_k127_5095403_10 ferredoxin-thioredoxin reductase activity K17892 GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015979,GO:0016491,GO:0016730,GO:0022900,GO:0030385,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 1.8.7.2 0.0000000000000000000005181 98.0
TLS2_k127_5095403_11 hydratase decarboxylase K02509,K02554 - 4.2.1.80 0.000000000000000001068 89.0
TLS2_k127_5095403_12 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000003667 90.0
TLS2_k127_5095403_13 Ferredoxin thioredoxin reductase catalytic beta chain K17892 - 1.8.7.2 0.0000000000000004715 78.0
TLS2_k127_5095403_14 Required for the activity of the bacterial periplasmic transport system of putrescine - - - 0.00000000000009099 71.0
TLS2_k127_5095403_15 GYD domain - - - 0.00000000002922 67.0
TLS2_k127_5095403_16 Tesmin/TSO1-like CXC domain - - - 0.0000005155 55.0
TLS2_k127_5095403_17 conserved protein, contains double-stranded beta-helix domain - - - 0.00003955 51.0
TLS2_k127_5095403_18 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000458 48.0
TLS2_k127_5095403_2 Binding-protein-dependent transport system inner membrane component K11071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 409.0
TLS2_k127_5095403_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072,K11076 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009944 404.0
TLS2_k127_5095403_4 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000000000000000000000007175 182.0
TLS2_k127_5095403_5 gluconolactonase activity K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000001295 168.0
TLS2_k127_5095403_6 DinB superfamily - - - 0.00000000000000000000000000000000000000001092 162.0
TLS2_k127_5095403_7 Ring hydroxylating beta subunit - - - 0.0000000000000000000000000000000000006078 145.0
TLS2_k127_5095403_8 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000000004094 123.0
TLS2_k127_5095403_9 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000001653 102.0
TLS2_k127_5112014_0 Belongs to the TPP enzyme family K01577,K01652 - 2.2.1.6,4.1.1.8 2.566e-257 798.0
TLS2_k127_5112014_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000003924 225.0
TLS2_k127_5115693_0 GTP-binding protein TypA K06207 - - 2.26e-254 797.0
TLS2_k127_5115693_1 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.00000000000000000000000000000000000000000008851 162.0
TLS2_k127_5119272_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 K00341 - 1.6.5.3 1.058e-200 643.0
TLS2_k127_5119272_1 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 606.0
TLS2_k127_5119272_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 522.0
TLS2_k127_5119272_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 493.0
TLS2_k127_5119272_4 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000002279 220.0
TLS2_k127_5119272_5 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.000000000000000000000000000000000000003606 151.0
TLS2_k127_5119272_6 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000009045 141.0
TLS2_k127_5119272_7 quinone binding K00337 - 1.6.5.3 0.0000000000000000000000000000000002234 136.0
TLS2_k127_5119272_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000006171 117.0
TLS2_k127_5120333_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 464.0
TLS2_k127_5120333_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000005181 133.0
TLS2_k127_5120333_2 structural constituent of ribosome K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000004181 87.0
TLS2_k127_5120859_0 Threonyl alanyl tRNA synthetase SAD K01872,K07050 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 304.0
TLS2_k127_5120859_1 Belongs to the ABC transporter superfamily K05816 - 3.6.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007437 283.0
TLS2_k127_5120859_2 Bacterial regulatory protein, Fis family K10126 - - 0.0000000004605 66.0
TLS2_k127_5131284_0 Belongs to the 5'-nucleotidase family K01081,K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006254 450.0
TLS2_k127_5131284_1 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008428 278.0
TLS2_k127_5131284_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000515 276.0
TLS2_k127_5131284_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006973 282.0
TLS2_k127_5131284_4 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001027 269.0
TLS2_k127_5131284_5 of the double-stranded beta helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000004286 233.0
TLS2_k127_5131284_6 Psort location Cytoplasmic, score 8.87 K05946 - 2.4.1.187 0.000000000000000000000000000000000000000000000000000000000000000001349 235.0
TLS2_k127_5131284_7 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000002521 182.0
TLS2_k127_5131284_8 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000002413 165.0
TLS2_k127_5131316_0 ABC transporter transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 560.0
TLS2_k127_5131316_1 PFAM Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 413.0
TLS2_k127_5131316_2 ABC transporter transmembrane region K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000001464 234.0
TLS2_k127_5140048_0 Aldo Keto reductase K07079 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 432.0
TLS2_k127_5140048_1 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 358.0
TLS2_k127_5140048_2 Pfam:Pyridox_oxidase - - - 0.000000000000000000000000000000000000000000000000000004607 192.0
TLS2_k127_5140048_3 peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000000000000000009457 127.0
TLS2_k127_5140048_4 Dodecin K09165 - - 0.0000000000000000002499 89.0
TLS2_k127_5140048_5 COG1062 Zn-dependent alcohol dehydrogenases, class III K00121 - 1.1.1.1,1.1.1.284 0.000000000000000003267 84.0
TLS2_k127_5140048_6 Putative zinc- or iron-chelating domain - - - 0.00000000000000002782 89.0
TLS2_k127_5141178_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005552 258.0
TLS2_k127_5141178_1 Domain of unknown function (DUF3368) - - - 0.00000000000000000000000000000000007753 138.0
TLS2_k127_5141178_2 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000000000000000000000000000002057 134.0
TLS2_k127_5141178_3 - - - - 0.0000000000000000000000000000003074 134.0
TLS2_k127_5141178_5 DinB superfamily - - - 0.000000001336 62.0
TLS2_k127_5141178_6 Transposase DDE domain - - - 0.000002107 52.0
TLS2_k127_5141178_7 required for the transposition of insertion element IS2404 - - - 0.0001665 45.0
TLS2_k127_514431_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008708 399.0
TLS2_k127_514431_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000000000003623 80.0
TLS2_k127_514431_2 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000637 81.0
TLS2_k127_514431_3 - - - - 0.0003405 46.0
TLS2_k127_5149219_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 532.0
TLS2_k127_5149219_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005833 302.0
TLS2_k127_5149219_2 TIGRFAM DNA polymerase III, delta K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000003248 192.0
TLS2_k127_5149219_3 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000001401 171.0
TLS2_k127_5149219_4 Methylates ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000002624 147.0
TLS2_k127_5149219_5 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000003624 133.0
TLS2_k127_5149219_6 PFAM 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.000000000000000000000000000006277 127.0
TLS2_k127_5158039_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 357.0
TLS2_k127_5158039_1 PFAM ABC transporter related K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003235 260.0
TLS2_k127_5158039_2 Transport permease protein K01992,K09690 - - 0.000000000000000000000000000000217 130.0
TLS2_k127_5158039_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000007383 104.0
TLS2_k127_51582_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001577 493.0
TLS2_k127_51582_1 carnitine dehydratase K01796 - 5.1.99.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006625 389.0
TLS2_k127_5175077_0 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006762 556.0
TLS2_k127_5175077_1 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004436 438.0
TLS2_k127_5175077_2 PFAM Glycosyl transferase family 2 K03669 GO:0005575,GO:0016020 - 0.000000000000000000000000000000000000000000000000000000000000004909 225.0
TLS2_k127_5175077_3 argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000006669 153.0
TLS2_k127_5175077_4 tetratricopeptide repeat - - - 0.00000000000000000000000000000002111 140.0
TLS2_k127_5186334_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005122 424.0
TLS2_k127_5186334_1 Transposase - - - 0.00000000000000218 78.0
TLS2_k127_519717_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 480.0
TLS2_k127_519717_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000224 267.0
TLS2_k127_519717_2 Alpha beta hydrolase - - - 0.0000000000000000000000008054 122.0
TLS2_k127_519717_3 Oxidoreductase molybdopterin binding - - - 0.0000004817 59.0
TLS2_k127_5203081_0 UvrD-like helicase C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 338.0
TLS2_k127_5203081_1 Aldo/keto reductase family K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 314.0
TLS2_k127_5203081_2 COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000007617 197.0
TLS2_k127_5203081_3 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000002179 159.0
TLS2_k127_5203081_4 YCII-related domain K09780 - - 0.0000000000000000000000000000002634 127.0
TLS2_k127_5203081_5 - - - - 0.00000000000000001751 96.0
TLS2_k127_5203081_6 ATPase domain of DNA mismatch repair MUTS family - - - 0.00000000000005621 78.0
TLS2_k127_5203081_7 - - - - 0.0000000000004677 82.0
TLS2_k127_5211594_0 involved in lipopolysaccharide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 501.0
TLS2_k127_5211594_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 413.0
TLS2_k127_5211594_2 DAHP synthetase I family K01627 - 2.5.1.55 0.0000005898 53.0
TLS2_k127_5215959_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 610.0
TLS2_k127_5215959_1 tryptophan synthase activity K01695 GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000001312 211.0
TLS2_k127_5215959_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000012 179.0
TLS2_k127_5216097_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 8.965e-198 630.0
TLS2_k127_5216097_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 385.0
TLS2_k127_5216097_2 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 308.0
TLS2_k127_5216097_3 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000003038 241.0
TLS2_k127_5216097_4 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 - - 0.000000000000000000000000000000000000000000003937 166.0
TLS2_k127_5216097_5 PFAM Biotin lipoate A B protein ligase family K03800 - 6.3.1.20 0.00000000000000000000000000000000000001708 150.0
TLS2_k127_5216097_6 Two component transcriptional regulator (LuxR family - - - 0.0000000000000000000000000000000001715 141.0
TLS2_k127_5217114_0 N-terminal TM domain of oligopeptide transport permease C - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 458.0
TLS2_k127_5217114_1 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 403.0
TLS2_k127_5217114_2 ABC transporter K02031,K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 345.0
TLS2_k127_5217114_3 transposase activity - - - 0.000000000000000000000000000002352 123.0
TLS2_k127_5217114_4 AntiSigma factor - - - 0.0000000000000000000001708 107.0
TLS2_k127_5217114_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000006323 81.0
TLS2_k127_5217114_6 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0001209 45.0
TLS2_k127_5240989_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 442.0
TLS2_k127_5240989_1 CAAX protease self-immunity K07052 - - 0.0000001043 56.0
TLS2_k127_5250295_0 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000241 355.0
TLS2_k127_5250295_1 PFAM molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 303.0
TLS2_k127_5250295_2 Twin-arginine translocation pathway signal protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001043 250.0
TLS2_k127_5258083_0 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 412.0
TLS2_k127_5258083_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 297.0
TLS2_k127_5258083_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 299.0
TLS2_k127_5258083_3 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 296.0
TLS2_k127_5258083_4 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000009137 220.0
TLS2_k127_5258083_5 PFAM Cupin 2, conserved barrel - - - 0.00000000000000000000000000000000005084 136.0
TLS2_k127_5282086_0 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 355.0
TLS2_k127_5282086_1 cation efflux - - - 0.000000000000000000000000000000000000000000000000000000000003419 217.0
TLS2_k127_5282086_2 hydrolase activity, hydrolyzing O-glycosyl compounds K00690 - 2.4.1.7 0.0000000000000000000000000000000000000000000000006152 183.0
TLS2_k127_5282086_3 silver ion transport K07787,K15726 - - 0.000000000000000000000000000000187 125.0
TLS2_k127_5282086_4 - - - - 0.00000000000000000001459 98.0
TLS2_k127_5333206_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 2.718e-250 813.0
TLS2_k127_5333206_1 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 452.0
TLS2_k127_5333206_2 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000008153 226.0
TLS2_k127_5333206_3 metalloendopeptidase activity K08602 - - 0.000000000000000000000000000002602 133.0
TLS2_k127_5333206_4 Helix-turn-helix domain - - - 0.00000000000000000000006984 109.0
TLS2_k127_5333206_5 Tetratricopeptide repeat - - - 0.0000000000000002169 91.0
TLS2_k127_5333206_6 secretion protein HlyD K03543 - - 0.000000003392 66.0
TLS2_k127_5338543_0 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 362.0
TLS2_k127_5338543_1 phosphonate ABC transporter, inner membrane subunit K02042 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 340.0
TLS2_k127_5338543_2 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 307.0
TLS2_k127_5338543_3 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000006872 243.0
TLS2_k127_5338543_4 Acetamidase K01426 - 3.5.1.4 0.0000000001445 65.0
TLS2_k127_5353963_0 MmgE/PrpD family - - - 0.0000000000000000000000000000000006772 141.0
TLS2_k127_5353963_1 A translational regulator that binds mRNA to regulate translation initiation and or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome- binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW K03563 - - 0.0000000000000004671 80.0
TLS2_k127_5353963_2 Major Facilitator Superfamily - - - 0.000001685 60.0
TLS2_k127_5362224_0 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003842 330.0
TLS2_k127_5362224_1 PFAM histone deacetylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003515 306.0
TLS2_k127_5362224_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.00000000000000000000000000000000000000000000004987 174.0
TLS2_k127_5362224_3 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.000000000000000007895 90.0
TLS2_k127_5392514_0 AMP-binding enzyme - - - 1.262e-208 668.0
TLS2_k127_5392514_1 Rieske (2fe-2S) K15060 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 326.0
TLS2_k127_5392514_2 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000203 72.0
TLS2_k127_5412802_0 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749,K14471,K14472 - 2.8.3.16,2.8.3.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 409.0
TLS2_k127_5412802_1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.00000000006736 65.0
TLS2_k127_5412802_2 oxidoreductase activity - - - 0.000001314 60.0
TLS2_k127_5436926_0 SAM-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 337.0
TLS2_k127_5436926_1 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 300.0
TLS2_k127_5436926_2 Adenosine/AMP deaminase K01488,K21053 - 3.5.4.2,3.5.4.4 0.000000000000000000000000000000000000000000000000000009945 192.0
TLS2_k127_5436926_3 Endonuclease Exonuclease phosphatase - - - 0.0000000000000000000000000000000001399 141.0
TLS2_k127_5449969_0 Cytochrome C and Quinol oxidase polypeptide I K15408 - 1.9.3.1 0.0 1069.0
TLS2_k127_5449969_1 COG3540 Phosphodiesterase alkaline phosphatase D - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 418.0
TLS2_k127_5449969_2 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006787 364.0
TLS2_k127_5449969_3 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004416 316.0
TLS2_k127_5449969_4 SMART Transport-associated and nodulation region - - - 0.000000000000000000000005133 104.0
TLS2_k127_5449969_5 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000000000006639 96.0
TLS2_k127_5451330_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008355 464.0
TLS2_k127_5451330_1 PFAM Peptidoglycan-binding domain 1 protein K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004918 259.0
TLS2_k127_5451330_2 PFAM extracellular solute-binding protein family 5 K02035 - - 0.00000009385 57.0
TLS2_k127_5451522_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 543.0
TLS2_k127_5451522_1 cyclic nucleotide binding K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002907 284.0
TLS2_k127_5451522_2 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000003633 98.0
TLS2_k127_5451522_3 - - - - 0.00000000000000005958 85.0
TLS2_k127_5451522_4 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000004151 75.0
TLS2_k127_5451522_5 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000329 69.0
TLS2_k127_5451522_6 InterPro IPR007367 - - - 0.00000006016 57.0
TLS2_k127_5468937_0 PFAM alpha beta hydrolase fold K01561 - 3.8.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 384.0
TLS2_k127_5468937_1 dipeptide transport K02035 - - 0.000000000000000000000000000000000000000000000003747 196.0
TLS2_k127_5468937_2 PFAM MOSC domain - - - 0.000000000000000000000000000000002711 134.0
TLS2_k127_5468937_3 Domain of unknown function (DUF4384) - - - 0.00000000000001144 88.0
TLS2_k127_5468937_4 nucleic acid-binding protein contains PIN domain - - - 0.00000000006757 65.0
TLS2_k127_5498063_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005289 562.0
TLS2_k127_5498063_1 - - - - 0.00000000000000000000000000000000000000004277 155.0
TLS2_k127_5511235_0 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000006103 206.0
TLS2_k127_5511235_1 Methyltransferase type 11 Methyltransferase type 12 - - - 0.00000000000000000000000000000000000000000000000000002291 198.0
TLS2_k127_5511235_2 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000003773 171.0
TLS2_k127_5511235_3 Methyltransferase type 11 Methyltransferase type 12 - - - 0.000000000000000000000000000000000000002638 156.0
TLS2_k127_5511235_4 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K09691 - - 0.000000000000000000000000004223 120.0
TLS2_k127_5511235_5 COG0463 Glycosyltransferases involved in cell wall biogenesis K16698 - - 0.00000000001004 76.0
TLS2_k127_5512901_0 Protein of unknown function (DUF420) K08976 - - 0.000000000000000000000000000000000000000000000000000000002162 204.0
TLS2_k127_5512901_1 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000005208 218.0
TLS2_k127_5512901_2 Protein of unknown function (DUF4058) - - - 0.00000000000000000000000000000000000000000000000000000002432 209.0
TLS2_k127_5512901_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000005078 214.0
TLS2_k127_5512901_4 Protein of unknown function (DUF420) K08976 - - 0.0000000004549 63.0
TLS2_k127_5535651_0 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 342.0
TLS2_k127_5535651_1 COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004575 311.0
TLS2_k127_5535651_2 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004479 240.0
TLS2_k127_5535651_3 DNA restriction-modification system - GO:0000737,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006304,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009036,GO:0009056,GO:0009057,GO:0009307,GO:0009987,GO:0015666,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044355,GO:0046483,GO:0046700,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0099046,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000005581 119.0
TLS2_k127_5559465_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 398.0
TLS2_k127_5559465_1 ATPase activity K02010,K02049,K02068,K02071,K06857,K10112 - 3.6.3.30,3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000377 226.0
TLS2_k127_5559465_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000007833 181.0
TLS2_k127_5569805_0 NADPH quinone reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 486.0
TLS2_k127_5569805_1 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 329.0
TLS2_k127_5569805_3 TIGRFAM transposase, IS605 OrfB family, central region - - - 0.000000000000000000000000000000000000000000000000699 179.0
TLS2_k127_5569805_4 COGs COG4591 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000009869 149.0
TLS2_k127_5569805_5 COGs COG4591 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000003739 59.0
TLS2_k127_5573439_0 thiamine-containing compound biosynthetic process K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003523 268.0
TLS2_k127_5573439_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000003679 86.0
TLS2_k127_5581812_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005178 484.0
TLS2_k127_5581812_1 DNA helicase - - - 0.0000000000000000000000000000000000000000002008 167.0
TLS2_k127_5581812_2 Putative esterase K07017 - - 0.00000000000000000008441 100.0
TLS2_k127_5581812_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000003351 63.0
TLS2_k127_5599625_0 High confidence in function and specificity K07484 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007175 504.0
TLS2_k127_5599625_1 Cysteine-rich motif following a subset of SET domains K07117 - - 0.000000000000000000000000000000000000000000000000001681 194.0
TLS2_k127_5599625_2 Family of unknown function (DUF5335) - - - 0.00000002456 59.0
TLS2_k127_5612928_0 Peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 391.0
TLS2_k127_5612928_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000734 259.0
TLS2_k127_5612928_2 protein secretion K13735,K20276 - - 0.0000000000000004918 90.0
TLS2_k127_5613111_0 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 297.0
TLS2_k127_5613111_1 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001886 245.0
TLS2_k127_5613111_2 PFAM NHL repeat containing protein - - - 0.0000000000000000000000000000000000000000000000001497 187.0
TLS2_k127_5613111_3 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000001657 115.0
TLS2_k127_5613433_0 Putative ATP-dependent DNA helicase recG C-terminal K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008698 558.0
TLS2_k127_5613433_1 CobQ CobB MinD ParA nucleotide binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 488.0
TLS2_k127_5613433_2 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 363.0
TLS2_k127_5613433_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002709 283.0
TLS2_k127_5613433_4 PFAM ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008755 278.0
TLS2_k127_5613433_5 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005814 285.0
TLS2_k127_5613433_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004681 268.0
TLS2_k127_5613433_7 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009799 253.0
TLS2_k127_5622521_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 5.974e-253 792.0
TLS2_k127_5622521_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000016 281.0
TLS2_k127_5622521_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000006171 211.0
TLS2_k127_5622521_3 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000434 184.0
TLS2_k127_5627291_0 Belongs to the beta-ketoacyl-ACP synthases family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 469.0
TLS2_k127_5627291_1 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 347.0
TLS2_k127_5627291_2 SAICAR synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 318.0
TLS2_k127_5627291_3 YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000000000000000000000000000002407 180.0
TLS2_k127_5627291_4 Belongs to the beta-ketoacyl-ACP synthases family - - - 0.000000000000000000000000001443 115.0
TLS2_k127_5635527_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000002182 246.0
TLS2_k127_5635527_1 Major Facilitator Superfamily K02445 - - 0.0000000000000000000000000000000000000000000000000000000001093 220.0
TLS2_k127_5635527_2 Yqey-like protein K09117 - - 0.000000000000000162 81.0
TLS2_k127_5635527_3 deoxyhypusine monooxygenase activity - - - 0.000000003343 67.0
TLS2_k127_5635527_4 Calcineurin-like phosphoesterase - - - 0.0009726 42.0
TLS2_k127_5648894_0 Domain of unknown function (DUF2760) - - - 0.00000000000000000000000000000000000006359 150.0
TLS2_k127_5648894_1 Belongs to the heat shock protein 70 family - - - 0.0000000000000000000000000000002828 126.0
TLS2_k127_5648894_2 SnoaL-like domain - - - 0.0000002606 56.0
TLS2_k127_5661102_0 Cobalamin biosynthesis protein CbiG K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 412.0
TLS2_k127_5661102_1 4-phosphoerythronate dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 350.0
TLS2_k127_5661102_2 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 314.0
TLS2_k127_5661102_3 Precorrin-3B C(17)-methyltransferase K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000000000000000000000000000879 252.0
TLS2_k127_5661102_4 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.00000000000000000000000000000000000000000000000001508 186.0
TLS2_k127_5662365_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 372.0
TLS2_k127_5662365_1 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000003762 222.0
TLS2_k127_5662365_2 reverse transcriptase - - - 0.000000000000000000000000000002142 122.0
TLS2_k127_5662365_3 Histidine kinase K02660,K03413,K11525 - - 0.0000000000000000000000001008 109.0
TLS2_k127_5662365_4 Transposase IS66 family - - - 0.0000000000000000000000003685 115.0
TLS2_k127_5662365_5 reverse transcriptase - - - 0.0000000000003273 74.0
TLS2_k127_5662365_6 Transposase K07487 - - 0.00001521 52.0
TLS2_k127_5662662_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008955 565.0
TLS2_k127_5662662_1 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000004448 197.0
TLS2_k127_5662662_2 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000008515 197.0
TLS2_k127_5684565_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 395.0
TLS2_k127_5684565_1 short-chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000008472 192.0
TLS2_k127_5684888_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000001308 253.0
TLS2_k127_5684888_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000132 231.0
TLS2_k127_5684888_2 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000362 204.0
TLS2_k127_5684888_3 - - - - 0.000000000005319 68.0
TLS2_k127_5691000_0 PFAM Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 410.0
TLS2_k127_5691000_1 AIR synthase related protein, N-terminal domain K01933,K11788 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1,6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 387.0
TLS2_k127_5691000_2 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 348.0
TLS2_k127_5691000_3 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000056 151.0
TLS2_k127_5692692_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008623 457.0
TLS2_k127_5692692_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 321.0
TLS2_k127_5692692_2 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000001141 99.0
TLS2_k127_5693091_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 297.0
TLS2_k127_5693091_1 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001013 284.0
TLS2_k127_5693091_2 Protein of unknown function (DUF4058) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002575 255.0
TLS2_k127_5693091_3 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000002031 198.0
TLS2_k127_5693091_4 von Willebrand factor, type A - - - 0.00000000000000000000000000000000009811 153.0
TLS2_k127_5693091_5 PFAM peptidase S58, DmpA - - - 0.00000000001935 68.0
TLS2_k127_5693091_6 nuclear chromosome segregation K09971 - - 0.000000001221 71.0
TLS2_k127_5710160_0 Associated with various cellular activities K09882 - 6.6.1.2 0.0000000000000000000000000000000000000000000000002601 186.0
TLS2_k127_5710160_1 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.00000000000000000000000000000003189 127.0
TLS2_k127_5710160_2 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.00000000000000000000000000008758 118.0
TLS2_k127_5710160_3 von Willebrand factor type A domain - - - 0.00009168 54.0
TLS2_k127_5710160_4 PFAM ATPase associated with various cellular activities, AAA_5 K04748 - - 0.0004192 48.0
TLS2_k127_5719142_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007789 370.0
TLS2_k127_5719142_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 310.0
TLS2_k127_5719142_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000001714 192.0
TLS2_k127_5719142_3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0031123,GO:0031404,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000001218 88.0
TLS2_k127_5719142_4 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000002993 67.0
TLS2_k127_576341_0 Belongs to the RtcB family K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 521.0
TLS2_k127_576341_1 Glucose dehydrogenase C-terminus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 358.0
TLS2_k127_576341_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004532 265.0
TLS2_k127_576341_3 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000002621 189.0
TLS2_k127_576341_4 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000000000000000001318 151.0
TLS2_k127_576341_5 PFAM Archease protein family (DUF101 UPF0211) - - - 0.0000000000000000000000000000003545 127.0
TLS2_k127_5767319_0 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 356.0
TLS2_k127_5767319_1 Belongs to the binding-protein-dependent transport system permease family K11960 - - 0.000000000000000000000000000000000000000000000001138 179.0
TLS2_k127_5767319_2 TIGRFAM ABC transporter, urea, ATP-binding protein, UrtD K11962 - - 0.0000000000000000000000000000000000003884 143.0
TLS2_k127_5772569_0 Lysin motif K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 313.0
TLS2_k127_5774567_0 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 362.0
TLS2_k127_5774567_1 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000242 278.0
TLS2_k127_5774567_2 Belongs to the UPF0109 family K06960 - - 0.00000000000000003835 82.0
TLS2_k127_5802834_0 alpha beta - - - 0.0000000000000000000000000000000000000000000000005217 185.0
TLS2_k127_5802834_1 alpha, beta - - - 0.00000000000000000000000000000000000004659 153.0
TLS2_k127_5802834_2 Uncharacterized conserved protein (DUF2196) - - - 0.0000000000004221 73.0
TLS2_k127_5802834_3 PFAM PilT protein, N-terminal - - - 0.00000005735 55.0
TLS2_k127_5802834_4 PFAM PilT protein, N-terminal - - - 0.00002144 51.0
TLS2_k127_5816581_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 615.0
TLS2_k127_5816581_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 366.0
TLS2_k127_5816581_2 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007225 361.0
TLS2_k127_5816581_3 transmembrane transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 338.0
TLS2_k127_5816581_4 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 293.0
TLS2_k127_5816581_5 N-terminal TM domain of oligopeptide transport permease C K02034,K12370 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009382 282.0
TLS2_k127_5816581_6 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000001011 214.0
TLS2_k127_5816581_7 PFAM Cupin 2 conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000001997 187.0
TLS2_k127_5822892_0 Belongs to the IlvD Edd family - - - 1.84e-220 698.0
TLS2_k127_5822892_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005293 594.0
TLS2_k127_5822892_10 transglycosylase - - - 0.000000000000000000001203 106.0
TLS2_k127_5822892_11 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.000000000000000007843 91.0
TLS2_k127_5822892_12 UbiA prenyltransferase family - - - 0.0002104 48.0
TLS2_k127_5822892_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 365.0
TLS2_k127_5822892_3 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000741 366.0
TLS2_k127_5822892_4 PFAM sigma-54 factor interaction domain-containing protein K10941 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 330.0
TLS2_k127_5822892_5 COG0208 Ribonucleotide reductase, beta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002229 260.0
TLS2_k127_5822892_6 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000004595 199.0
TLS2_k127_5822892_7 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000009776 191.0
TLS2_k127_5822892_8 molybdenum cofactor guanylyltransferase activity K03752,K13818 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.77 0.0000000000000000000000000000000000000000000000002471 188.0
TLS2_k127_5822892_9 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000009245 110.0
TLS2_k127_5832967_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000002271 152.0
TLS2_k127_5832967_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000196 142.0
TLS2_k127_5838976_0 PFAM Alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 535.0
TLS2_k127_5838976_1 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 318.0
TLS2_k127_5838976_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 312.0
TLS2_k127_5838976_3 Electron transfer flavoprotein FAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000001464 201.0
TLS2_k127_5838976_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000002093 183.0
TLS2_k127_5846251_0 And related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 399.0
TLS2_k127_5846251_1 PFAM L-carnitine dehydratase bile acid-inducible protein F K18702 - 2.8.3.19 0.000000000000000005764 85.0
TLS2_k127_5846251_2 DDE superfamily endonuclease - - - 0.000000725 55.0
TLS2_k127_5861175_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 500.0
TLS2_k127_5861175_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 394.0
TLS2_k127_5861175_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000002705 220.0
TLS2_k127_5861175_3 biotin-[acetyl-CoA-carboxylase] ligase activity K03523,K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000009493 171.0
TLS2_k127_5861175_4 - - - - 0.00000000000101 74.0
TLS2_k127_5861175_5 - - - - 0.0001508 50.0
TLS2_k127_5869681_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 556.0
TLS2_k127_5869681_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 452.0
TLS2_k127_5869681_2 nitrogen compound transport K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 364.0
TLS2_k127_5869681_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 350.0
TLS2_k127_5869681_4 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 317.0
TLS2_k127_5869681_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002936 259.0
TLS2_k127_5869681_6 Protein conserved in bacteria K07011 - - 0.00000000000000000000000000000000000000000000000000004444 194.0
TLS2_k127_5869681_7 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.0000000004608 65.0
TLS2_k127_5876690_0 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007152 523.0
TLS2_k127_5876690_1 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001139 237.0
TLS2_k127_5876690_2 Transmembrane and TPR repeat-containing protein 1 - - - 0.0000259 53.0
TLS2_k127_5878871_0 membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 422.0
TLS2_k127_5878871_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 355.0
TLS2_k127_5878871_2 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000001293 243.0
TLS2_k127_5878871_3 CsbD-like - - - 0.000000000000000000003122 96.0
TLS2_k127_5878871_4 UPF0391 membrane protein - - - 0.0000000000002328 72.0
TLS2_k127_5878871_5 response regulator K02667 - - 0.0000000000008255 72.0
TLS2_k127_5878871_6 PilZ domain K02676 - - 0.00000000006706 70.0
TLS2_k127_5878871_7 Bacterial protein of unknown function (DUF883) - - - 0.000003531 54.0
TLS2_k127_5878871_8 Polyketide cyclase / dehydrase and lipid transport - - - 0.00009032 53.0
TLS2_k127_5878871_9 cheY-homologous receiver domain K03413 - - 0.0004888 47.0
TLS2_k127_5886934_0 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008607 398.0
TLS2_k127_5886934_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 366.0
TLS2_k127_5886934_10 Radical_SAM C-terminal domain K07139 - - 0.00000000461 58.0
TLS2_k127_5886934_2 PFAM ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 344.0
TLS2_k127_5886934_3 Aldolase/RraA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001253 260.0
TLS2_k127_5886934_4 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006367 245.0
TLS2_k127_5886934_5 Modulates RecA activity K03565 - - 0.0000000000000000000000000000000000000000000000000000007188 199.0
TLS2_k127_5886934_6 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.00000000000000000000002233 104.0
TLS2_k127_5886934_7 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000000001979 81.0
TLS2_k127_5886934_9 Mo-molybdopterin cofactor metabolic process K03636 - - 0.0000000000114 72.0
TLS2_k127_5891452_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 316.0
TLS2_k127_5891452_1 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 286.0
TLS2_k127_5891452_2 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 0.000000000000000000000000000000000000000000000000000000000006989 212.0
TLS2_k127_5891452_3 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000002164 195.0
TLS2_k127_5891452_4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.000000000000000000000000000000000000000002286 171.0
TLS2_k127_5891452_5 PFAM Hemolysin-type calcium-binding repeat (2 copies) K01406 - 3.4.24.40 0.000000000005767 72.0
TLS2_k127_5891452_6 Glucose / Sorbosone dehydrogenase - - - 0.000000000009188 79.0
TLS2_k127_5893251_0 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 4.167e-228 714.0
TLS2_k127_5893251_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 391.0
TLS2_k127_5893929_0 oxidoreductase activity K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 578.0
TLS2_k127_5893929_1 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 386.0
TLS2_k127_5893929_2 ATPase associated with K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 291.0
TLS2_k127_5893929_3 Von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000024 269.0
TLS2_k127_5893929_4 Glycosyl transferases group 1 - - - 0.0000000000000000000007405 98.0
TLS2_k127_5911421_0 Belongs to the ABC transporter superfamily K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 372.0
TLS2_k127_5911421_1 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 356.0
TLS2_k127_5911421_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 298.0
TLS2_k127_5911421_3 Acetolactate synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005852 269.0
TLS2_k127_5911421_4 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003243 259.0
TLS2_k127_5911421_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000004536 218.0
TLS2_k127_5911421_6 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000003931 201.0
TLS2_k127_5911421_7 COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein K03790 - 2.3.1.128 0.00000000000000000000000000000005434 133.0
TLS2_k127_5911421_8 Cupin 2, conserved barrel domain protein - - - 0.000000000000000003495 89.0
TLS2_k127_5921714_0 KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 586.0
TLS2_k127_5921714_1 zinc ion binding - - - 0.000000001009 71.0
TLS2_k127_5921714_2 MacB-like periplasmic core domain K02004 - - 0.0006524 42.0
TLS2_k127_5937171_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 498.0
TLS2_k127_5937171_1 PFAM Carbamoyl-phosphate synthase L chain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 485.0
TLS2_k127_5937171_2 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.00000000000000000006446 95.0
TLS2_k127_5937171_3 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000004175 73.0
TLS2_k127_5938715_0 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005224 464.0
TLS2_k127_5938715_1 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 359.0
TLS2_k127_5938715_2 TIGRFAM UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000008195 138.0
TLS2_k127_5938715_3 TIGRFAM hydrolase, TatD family K03424 - - 0.0000000000003038 72.0
TLS2_k127_5992774_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000001408 207.0
TLS2_k127_5992774_1 lactoylglutathione lyase activity K11210,K21253,K21264,K21265 GO:0003674,GO:0003824,GO:0004364,GO:0008150,GO:0016740,GO:0016765,GO:0042221,GO:0046677,GO:0050896 2.5.1.18 0.000000003394 63.0
TLS2_k127_5994252_0 FAD linked oxidase domain protein - - - 1.437e-261 837.0
TLS2_k127_5994252_1 Chlorite dismutase - - - 0.0000000006125 60.0
TLS2_k127_6000356_0 Flavin-binding monooxygenase-like K03379,K21730 - 1.14.13.160,1.14.13.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 516.0
TLS2_k127_6000356_1 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 297.0
TLS2_k127_6000356_2 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001312 251.0
TLS2_k127_6000356_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000252 239.0
TLS2_k127_6000356_4 PAC2 family - - - 0.0000000000000000000000000000002379 130.0
TLS2_k127_6010766_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 508.0
TLS2_k127_6010766_1 SAF K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 468.0
TLS2_k127_6010766_2 TIGRFAM acetoacetyl-CoA synthase K01907 - 6.2.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 340.0
TLS2_k127_6010766_3 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510,K12660 - 4.1.2.52,4.1.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005686 280.0
TLS2_k127_6010766_4 - - - - 0.00000000000000000000000004088 110.0
TLS2_k127_6019407_0 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 360.0
TLS2_k127_6019407_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000001485 203.0
TLS2_k127_6019407_2 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.00000000000002324 84.0
TLS2_k127_6019407_3 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.0000000002162 71.0
TLS2_k127_6021039_0 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 297.0
TLS2_k127_6021039_1 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001405 284.0
TLS2_k127_6021039_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000002358 211.0
TLS2_k127_6021039_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000003279 143.0
TLS2_k127_602603_0 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 340.0
TLS2_k127_602603_1 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003037 299.0
TLS2_k127_602603_2 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008574 254.0
TLS2_k127_602603_3 transferase activity, transferring glycosyl groups - - - 0.00000000000000000001689 95.0
TLS2_k127_6059037_0 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 286.0
TLS2_k127_6059037_1 LUD domain K18929 - - 0.00000023 55.0
TLS2_k127_6063695_0 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000247 181.0
TLS2_k127_6063695_1 PFAM MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000003738 157.0
TLS2_k127_6063695_2 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000009733 160.0
TLS2_k127_6063695_3 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000000000001415 136.0
TLS2_k127_6063695_4 general secretion pathway protein K02450 - - 0.000000000000000000000008889 118.0
TLS2_k127_6063695_5 Involved in the TonB-independent uptake of proteins K03641 - - 0.000000002825 65.0
TLS2_k127_6063695_6 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0004779 51.0
TLS2_k127_6075125_0 synthase K11779 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005749 420.0
TLS2_k127_6075125_1 peptidase dimerisation domain protein K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005495 385.0
TLS2_k127_6075125_2 endoribonuclease L-PSP - - - 0.000000000000000000002479 98.0
TLS2_k127_6075125_3 Endoribonuclease L-PSP - - - 0.0000000000001735 80.0
TLS2_k127_6075125_4 translation initiation inhibitor, yjgF family - - - 0.00009044 53.0
TLS2_k127_608812_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1264.0
TLS2_k127_608812_1 Putative peptidoglycan binding domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 330.0
TLS2_k127_608812_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000004234 160.0
TLS2_k127_608812_3 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000000000000003779 114.0
TLS2_k127_608812_4 Putative nucleotidyltransferase substrate binding domain - - - 0.000000000000000000004278 98.0
TLS2_k127_6101251_0 transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005218 538.0
TLS2_k127_6101251_1 ABC transporter substrate binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 367.0
TLS2_k127_6101251_2 transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000126 278.0
TLS2_k127_6101251_3 Universal stress protein K06149 - - 0.0003129 47.0
TLS2_k127_6103828_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 353.0
TLS2_k127_6103828_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 315.0
TLS2_k127_6103828_2 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000001749 116.0
TLS2_k127_6103828_4 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000001933 68.0
TLS2_k127_6103828_5 Putative zinc- or iron-chelating domain - - - 0.0003593 52.0
TLS2_k127_6105450_0 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 530.0
TLS2_k127_6105450_1 Adenylosuccinate lyase C-terminus K01756,K01857 - 4.3.2.2,5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 412.0
TLS2_k127_6105450_2 acyl-CoA transferase carnitine dehydratase K18702 - 2.8.3.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008236 329.0
TLS2_k127_6105450_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 327.0
TLS2_k127_6105450_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000004968 215.0
TLS2_k127_6105450_5 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K13039 - 4.1.1.79 0.00000000000000000000000000000000000000002147 160.0
TLS2_k127_6105450_6 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K06034 - 4.1.1.79 0.0000000000000000000000000000000000000001793 155.0
TLS2_k127_6108436_0 protein conserved in cyanobacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 289.0
TLS2_k127_6108436_1 COG1840 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003222 273.0
TLS2_k127_6108436_2 major facilitator superfamily K03446 - - 0.0000000000000000000000000000000003107 136.0
TLS2_k127_6108436_3 O-methyltransferase - - - 0.00000000000000000000000000137 121.0
TLS2_k127_6120932_0 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009091 531.0
TLS2_k127_6120932_1 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000001405 244.0
TLS2_k127_6120932_2 PFAM ROSMUCR transcriptional regulator - - - 0.000000000000000000000009045 106.0
TLS2_k127_6120932_3 PFAM Phosphoglycerate mutase K08296 - - 0.000000000000000000003689 100.0
TLS2_k127_613458_0 4-phosphoerythronate dehydrogenase activity K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005528 345.0
TLS2_k127_613458_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007011 346.0
TLS2_k127_613458_2 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 301.0
TLS2_k127_613458_3 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000005042 243.0
TLS2_k127_613458_4 17 kDa outer membrane surface antigen - - - 0.000000000000000000000000000000000000001964 152.0
TLS2_k127_613458_5 Domain of unknown function (DUF4160) - - - 0.0000000000000000000000000000000000001209 143.0
TLS2_k127_613458_6 NIPSNAP - - - 0.0000000000000000000000000000000000003242 149.0
TLS2_k127_613458_7 Protein of unknown function (DUF2442) - - - 0.000000000000000000000000000000002701 131.0
TLS2_k127_613458_8 Ca2 -binding protein (EF-Hand superfamily - - - 0.0000009721 60.0
TLS2_k127_6142253_0 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001672 286.0
TLS2_k127_6142253_1 Dihydroorotase K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000004981 207.0
TLS2_k127_61587_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 2.346e-197 629.0
TLS2_k127_61587_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 436.0
TLS2_k127_61587_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000002232 196.0
TLS2_k127_6169737_0 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 396.0
TLS2_k127_6169737_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007579 351.0
TLS2_k127_6169737_2 MgtE intracellular region K06213 - - 0.0000000000000000000009722 98.0
TLS2_k127_6209911_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 592.0
TLS2_k127_6209911_1 Domain of unknown function (DUF5122) beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 436.0
TLS2_k127_6209911_2 Bacterial pre-peptidase C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003451 280.0
TLS2_k127_6209911_3 PFAM Carbohydrate-selective porin OprB - - - 0.000000000000000000000000000000002577 132.0
TLS2_k127_6214814_0 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000078 239.0
TLS2_k127_6214814_1 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000001032 143.0
TLS2_k127_6214814_2 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.0000000000000000000000000000000006032 144.0
TLS2_k127_6214814_3 Cupin 2, conserved barrel domain protein - - - 0.000000000000000004248 88.0
TLS2_k127_6225377_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.383e-291 902.0
TLS2_k127_6225377_1 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000383 381.0
TLS2_k127_6249087_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 441.0
TLS2_k127_6249087_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 315.0
TLS2_k127_6249087_2 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000028 228.0
TLS2_k127_6249087_3 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000001077 155.0
TLS2_k127_6249087_4 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000004215 110.0
TLS2_k127_6249087_5 Protein conserved in bacteria - - - 0.0000000000000000753 83.0
TLS2_k127_6249087_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000009309 74.0
TLS2_k127_6249087_7 thiolester hydrolase activity K06889 - - 0.000002042 52.0
TLS2_k127_6267111_0 lipid kinase activity K07029 GO:0003674,GO:0003824,GO:0004143,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.107 0.00000000000000000000000000000000000000000000000000000000000000000008235 239.0
TLS2_k127_6267111_1 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000001166 212.0
TLS2_k127_6267111_2 TIGRFAM carbohydrate kinase, thermoresistant glucokinase family K00851 - 2.7.1.12 0.0000000000000000000000000000000000000000000007265 170.0
TLS2_k127_6267111_3 TLC ATP/ADP transporter K03301 - - 0.00000000000000000000000000000000000001682 167.0
TLS2_k127_6267111_4 transcription factor binding K02584,K11914 - - 0.0000000000000001115 84.0
TLS2_k127_6267184_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 513.0
TLS2_k127_6267987_0 COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - 0.0 1086.0
TLS2_k127_6267987_1 Alcohol dehydrogenase GroES-like domain K00004 - 1.1.1.303,1.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000001248 245.0
TLS2_k127_6267987_2 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000001951 196.0
TLS2_k127_6267987_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K08318 - 1.1.1.373,1.1.1.61 0.000000006279 61.0
TLS2_k127_6282492_0 Domain of unknown function (DUF4405) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 331.0
TLS2_k127_6282492_1 Cytochrome b(C-terminal)/b6/petD - - - 0.0000000000000000000000000000000000000000000000000000000000001046 222.0
TLS2_k127_6282492_2 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000004243 207.0
TLS2_k127_6282492_3 oxidoreductase activity, acting on diphenols and related substances as donors K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000000000000006376 168.0
TLS2_k127_6282492_4 Cytochrome c K02305 - - 0.000000000000000000000000000000155 138.0
TLS2_k127_6282492_5 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.00000000000000000000001876 108.0
TLS2_k127_6282492_6 Belongs to the thiolase family K00632 - 2.3.1.16 0.000000000001344 69.0
TLS2_k127_6282492_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.00001403 57.0
TLS2_k127_6291671_1 Amidohydrolase - - - 0.00000000000000000000006098 111.0
TLS2_k127_6291671_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000001903 99.0
TLS2_k127_6291671_3 N-terminal half of MaoC dehydratase - - - 0.000000000000005775 81.0
TLS2_k127_6291671_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.000000001026 64.0
TLS2_k127_6291671_5 dehydratase - - - 0.0000007079 57.0
TLS2_k127_633019_0 PFAM Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 377.0
TLS2_k127_633019_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 311.0
TLS2_k127_633019_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.000000000000000000000000000000000000000000000000000005797 192.0
TLS2_k127_633019_3 Cytochrome c556 - - - 0.00000000000008104 78.0
TLS2_k127_633019_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.0000000001119 62.0
TLS2_k127_6333132_0 DEAD DEAH box helicase K06877 - - 1.897e-206 662.0
TLS2_k127_6333132_1 dipeptidyl-peptidase activity K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 572.0
TLS2_k127_6333132_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 398.0
TLS2_k127_6333132_3 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000275 254.0
TLS2_k127_6333132_4 DsbA oxidoreductase - - - 0.00000000000000000000000000000000000000000000000003161 184.0
TLS2_k127_6340227_0 transport systems K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 327.0
TLS2_k127_6340227_1 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000001723 211.0
TLS2_k127_6340227_2 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000726 164.0
TLS2_k127_6361783_0 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 328.0
TLS2_k127_6361783_1 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000003209 271.0
TLS2_k127_6361783_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000007597 193.0
TLS2_k127_6361783_3 Cupin domain - - - 0.00000000000000000000000000001033 123.0
TLS2_k127_6407246_0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005806 327.0
TLS2_k127_6407246_1 protein conserved in cyanobacteria - - - 0.000000000000000000000000000000000000000000000000000000000000001603 226.0
TLS2_k127_6429529_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007421 334.0
TLS2_k127_6429529_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000456 138.0
TLS2_k127_6429529_2 - - - - 0.00000000000000000000000011 113.0
TLS2_k127_6474521_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 583.0
TLS2_k127_6474521_1 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 541.0
TLS2_k127_6474521_10 PFAM Cold-shock protein, DNA-binding K03704 - - 0.000000000000000000000000006594 110.0
TLS2_k127_6474521_11 Na H antiporter - - - 0.0000000000000000000000006995 109.0
TLS2_k127_6474521_12 PFAM Na H antiporter subunit K05571 - - 0.00000000000000000003178 93.0
TLS2_k127_6474521_13 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05570 - - 0.0000000000000000832 83.0
TLS2_k127_6474521_14 - - - - 0.0000003972 54.0
TLS2_k127_6474521_15 Multisubunit Na H antiporter, MnhB subunit K05566 - - 0.00001526 54.0
TLS2_k127_6474521_2 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12141 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 522.0
TLS2_k127_6474521_3 SMART Elongator protein 3 MiaB NifB K07139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 333.0
TLS2_k127_6474521_4 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000001528 214.0
TLS2_k127_6474521_5 NUDIX domain - - - 0.00000000000000000000000000000000000007014 149.0
TLS2_k127_6474521_6 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.000000000000000000000000000000000000171 147.0
TLS2_k127_6474521_7 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L - - - 0.0000000000000000000000000000000001959 136.0
TLS2_k127_6474521_8 multisubunit Na H antiporter MnhE subunit K05569 - - 0.000000000000000000000000000000001239 139.0
TLS2_k127_6474521_9 PFAM thioesterase superfamily K18700 - 3.1.2.29 0.000000000000000000000000004303 117.0
TLS2_k127_6481544_0 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 488.0
TLS2_k127_6481544_1 membrane organization - - - 0.00000000000000000000000000000000000000000000000000000000000000002892 237.0
TLS2_k127_6483870_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 373.0
TLS2_k127_6483870_1 glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 357.0
TLS2_k127_6483870_2 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002537 354.0
TLS2_k127_6483870_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000003541 84.0
TLS2_k127_6483870_4 Transposase - - - 0.0000817 47.0
TLS2_k127_6483978_0 CHASE2 K01768 - 4.6.1.1 4.693e-219 705.0
TLS2_k127_6483978_1 FecR protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 387.0
TLS2_k127_648979_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 322.0
TLS2_k127_648979_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000001613 222.0
TLS2_k127_648979_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000008463 58.0
TLS2_k127_6549731_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 601.0
TLS2_k127_6549731_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 377.0
TLS2_k127_6549731_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 306.0
TLS2_k127_6549731_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000005301 249.0
TLS2_k127_6549731_4 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000001032 247.0
TLS2_k127_6549731_5 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000007526 204.0
TLS2_k127_6550495_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008234 499.0
TLS2_k127_6550495_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000000000000000000000000000000002076 201.0
TLS2_k127_6550495_2 MoeA C-terminal region (domain IV) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000002951 199.0
TLS2_k127_6552921_0 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006798 574.0
TLS2_k127_6552921_1 III protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005601 307.0
TLS2_k127_6552921_2 PFAM ATP-NAD AcoX kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003374 287.0
TLS2_k127_6552921_3 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 0.000000001775 61.0
TLS2_k127_6556066_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K01083,K01113,K03787 GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.1,3.1.3.5,3.1.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000006779 248.0
TLS2_k127_6556066_1 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000446 220.0
TLS2_k127_6556066_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000003157 177.0
TLS2_k127_6556066_3 PFAM Class I peptide chain release factor K15034 - - 0.0000000000000000000000000004646 115.0
TLS2_k127_6557296_0 Putative glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 298.0
TLS2_k127_6557296_1 Putative cyclase K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000111 210.0
TLS2_k127_6557296_2 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000002092 148.0
TLS2_k127_6557296_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000002458 114.0
TLS2_k127_6558384_0 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 482.0
TLS2_k127_6558384_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 316.0
TLS2_k127_6558384_2 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 308.0
TLS2_k127_6558384_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 305.0
TLS2_k127_6558384_4 Preprotein translocase K03210 - - 0.000000000000000009566 87.0
TLS2_k127_6558384_5 protein trimerization K05807 - - 0.000002413 56.0
TLS2_k127_6559010_0 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000002543 228.0
TLS2_k127_6559010_1 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000007769 58.0
TLS2_k127_6560917_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 499.0
TLS2_k127_6560917_1 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002232 254.0
TLS2_k127_6560917_2 3-beta hydroxysteroid dehydrogenase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000002 224.0
TLS2_k127_6560917_3 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.00000000000000000000003137 101.0
TLS2_k127_6565219_0 intramolecular transferase activity, transferring amino groups K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 294.0
TLS2_k127_6565219_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000002679 71.0
TLS2_k127_6565219_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000001655 67.0
TLS2_k127_6565219_3 cellulose binding - - - 0.0000000001627 66.0
TLS2_k127_6565219_4 - - - - 0.0000001715 53.0
TLS2_k127_6587752_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070041,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000004297 247.0
TLS2_k127_6587752_1 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000007978 183.0
TLS2_k127_6590331_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 390.0
TLS2_k127_6590331_1 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000766 197.0
TLS2_k127_6590771_0 Binds to RNA in loop regions with AU-rich sequences K22469 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000008081 155.0
TLS2_k127_6590771_1 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000001198 78.0
TLS2_k127_6594525_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 475.0
TLS2_k127_6594525_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 469.0
TLS2_k127_6594525_3 major facilitator superfamily K03446 - - 0.00000001712 61.0
TLS2_k127_6606956_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 566.0
TLS2_k127_6606956_1 Vitamin K epoxide reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003109 254.0
TLS2_k127_6606956_3 - - - - 0.00000000000000006903 85.0
TLS2_k127_6608523_0 ATPases associated with a variety of cellular activities K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 493.0
TLS2_k127_6608523_1 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 401.0
TLS2_k127_6608523_2 COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 317.0
TLS2_k127_6608523_3 Aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004222 256.0
TLS2_k127_6608523_4 phosphatidylinositol kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000005259 237.0
TLS2_k127_6613365_0 Histidine kinase K13924 - 2.1.1.80,3.1.1.61 6.434e-252 801.0
TLS2_k127_6613365_1 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 1.402e-223 709.0
TLS2_k127_6628834_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005974 454.0
TLS2_k127_6628834_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001165 284.0
TLS2_k127_6628834_2 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001321 292.0
TLS2_k127_6628834_3 PFAM transposase mutator type K07493 - - 0.00000000000000000000000004857 126.0
TLS2_k127_6628834_4 Preprotein translocase SecG subunit K03075 - - 0.0000000000000000002503 92.0
TLS2_k127_6633402_0 IMG reference gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 343.0
TLS2_k127_6633402_1 PFAM Transposase DDE domain - - - 0.0000000000000000000000000000000000000001296 154.0
TLS2_k127_6633402_2 - - - - 0.00000000000000000000005779 100.0
TLS2_k127_6633402_3 - - - - 0.000000000000000000000094 104.0
TLS2_k127_6633402_4 Winged helix-turn helix - - - 0.000000005631 67.0
TLS2_k127_6633818_0 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000009002 202.0
TLS2_k127_6633818_1 PFAM AsmA family protein K07289 - - 0.000000000000000000001348 111.0
TLS2_k127_6633818_2 ROS/MUCR transcriptional regulator protein - - - 0.00000000001579 68.0
TLS2_k127_6649249_0 Peptidase family M1 domain K08776 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 574.0
TLS2_k127_6649249_1 anthranilate phosphoribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 400.0
TLS2_k127_6658833_0 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000002148 194.0
TLS2_k127_6658833_1 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000002204 153.0
TLS2_k127_6658833_2 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000001382 130.0
TLS2_k127_6658833_3 Two component transcriptional regulator (LuxR family - - - 0.000000007211 60.0
TLS2_k127_6660617_0 metal-dependent hydrolase of the TIM-barrel fold K07046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 424.0
TLS2_k127_6660617_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000001049 247.0
TLS2_k127_6660617_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000003683 228.0
TLS2_k127_6660617_3 nuclease activity - - - 0.00000000000000000000000000000000000000000000000000009879 188.0
TLS2_k127_6660617_4 SpoVT / AbrB like domain - - - 0.000000000000000000000008685 106.0
TLS2_k127_6660617_5 PFAM YebG family protein K09918 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000002212 100.0
TLS2_k127_6661177_0 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 464.0
TLS2_k127_6661177_1 Short-chain dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000209 190.0
TLS2_k127_6661177_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000006184 119.0
TLS2_k127_6661177_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000004492 69.0
TLS2_k127_6672439_0 Bacterial extracellular solute-binding proteins, family 5 Middle K13893 - - 7.5e-204 651.0
TLS2_k127_6672439_1 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 574.0
TLS2_k127_6672439_2 PFAM Binding-protein-dependent transport system inner membrane component K13894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 419.0
TLS2_k127_6672439_3 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005014 370.0
TLS2_k127_6672439_4 FMN-dependent dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 333.0
TLS2_k127_6672439_5 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001985 267.0
TLS2_k127_6672439_6 Belongs to the UPF0250 family K09158 - - 0.000000000000000000003927 96.0
TLS2_k127_6673612_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 411.0
TLS2_k127_6673612_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007388 259.0
TLS2_k127_6686457_0 Glutamine synthetase, catalytic domain K01949 - 6.3.4.12 2.277e-211 669.0
TLS2_k127_6686457_1 IMP dehydrogenase / GMP reductase domain K22083 - 2.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008647 393.0
TLS2_k127_6688249_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007172 376.0
TLS2_k127_6688249_1 deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 345.0
TLS2_k127_6688249_2 PFAM SMP-30 Gluconolaconase LRE domain protein K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 289.0
TLS2_k127_6688249_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001488 258.0
TLS2_k127_6688249_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000003935 198.0
TLS2_k127_6688249_5 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000002648 101.0
TLS2_k127_6700397_0 DoxX - - - 0.0000000000000000000000000000000000006665 143.0
TLS2_k127_6700397_1 - - - - 0.0000000000000000000000000000004299 134.0
TLS2_k127_6700397_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000001103 79.0
TLS2_k127_6700397_3 DinB superfamily - - - 0.000000005198 66.0
TLS2_k127_6720838_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 529.0
TLS2_k127_6720838_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 424.0
TLS2_k127_6736613_0 Inositol monophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000008643 214.0
TLS2_k127_6736613_1 prephenate dehydrogenase K04517,K14187 - 1.3.1.12,5.4.99.5 0.0000000000000000000000000000000000000000000000000001902 205.0
TLS2_k127_6736613_2 adenylyltransferase K00969 - 2.7.7.18 0.0000000000000000000003862 103.0
TLS2_k127_6736613_3 NIPSNAP - - - 0.0000000000000005877 80.0
TLS2_k127_6736613_4 PFAM blue (type 1) copper domain protein - - - 0.000006032 54.0
TLS2_k127_674166_0 recombinase XerD K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005502 290.0
TLS2_k127_674166_1 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000039 141.0
TLS2_k127_674166_2 Ribosomal protein S20 K02968 - - 0.000000000000003877 79.0
TLS2_k127_674166_3 Lipopolysaccharide-assembly - - - 0.0008459 49.0
TLS2_k127_6745292_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001781 269.0
TLS2_k127_6745292_1 Protein of unknown function DUF86 - - - 0.000000000000000000000000000000000000000000001891 169.0
TLS2_k127_6745292_2 Nucleotidyltransferase domain - - - 0.0000000000000000000000000004379 120.0
TLS2_k127_6745292_3 YHS domain K06966 - 3.2.2.10 0.00000000000000000004766 93.0
TLS2_k127_6745292_4 - K07403 - - 0.0000184 51.0
TLS2_k127_6750549_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 336.0
TLS2_k127_6750549_1 Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000008972 214.0
TLS2_k127_6750549_2 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661 GO:0003674,GO:0003824,GO:0005488,GO:0006732,GO:0008150,GO:0008152,GO:0008935,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:0071890,GO:1901576,GO:1901661,GO:1901663 4.1.3.36 0.0000000000000000000000000000000000000005002 150.0
TLS2_k127_6750549_3 Domain of unknown function (DUF4258) - - - 0.0000000000000000000000000000000000005506 141.0
TLS2_k127_6750549_4 - - - - 0.00000000000000000006258 92.0
TLS2_k127_6750549_5 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.000000000007268 72.0
TLS2_k127_6751482_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008925 409.0
TLS2_k127_6751482_1 Response regulator receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006506 343.0
TLS2_k127_6751482_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 318.0
TLS2_k127_6751482_3 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000001016 224.0
TLS2_k127_6751482_4 Esterase-like activity of phytase - - - 0.000000000000000000000000000000000000000000000000000001744 204.0
TLS2_k127_6751482_5 Putative transmembrane protein (PGPGW) - - - 0.00000000000000000000000000000199 126.0
TLS2_k127_6751482_6 Response regulator, receiver - - - 0.000000000000000000000004797 105.0
TLS2_k127_6751482_7 cheY-homologous receiver domain K07814 - - 0.0000000000000004526 81.0
TLS2_k127_6760646_0 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 340.0
TLS2_k127_6760646_1 PFAM chalcone and stilbene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007853 265.0
TLS2_k127_6760646_2 cephalosporin-C deacetylase activity K01060 - 3.1.1.41 0.000000000000000000000000000000000000000000001971 176.0
TLS2_k127_6760646_3 Methyltransferase domain - - - 0.0000000004629 65.0
TLS2_k127_6761406_0 PFAM Peptidase family M3 K01414 - 3.4.24.70 2.346e-257 801.0
TLS2_k127_6761406_1 Gamma-glutamyltranspeptidase - - - 7.231e-195 624.0
TLS2_k127_6761406_2 Gamma-glutamyltranspeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 387.0
TLS2_k127_6761406_3 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000005289 192.0
TLS2_k127_6761406_4 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000000006253 102.0
TLS2_k127_6780251_0 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 384.0
TLS2_k127_6780251_1 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003687 280.0
TLS2_k127_6780251_2 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005388 245.0
TLS2_k127_6780251_3 ATPase (AAA - - - 0.00000003692 57.0
TLS2_k127_6780527_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 531.0
TLS2_k127_6780527_1 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008515 456.0
TLS2_k127_6780527_2 PASTA domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009984 457.0
TLS2_k127_6780527_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 307.0
TLS2_k127_6780527_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000001606 208.0
TLS2_k127_6780527_5 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.00000000000000000000000000002877 122.0
TLS2_k127_6780527_6 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000444 108.0
TLS2_k127_678377_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 5.74e-252 798.0
TLS2_k127_678377_1 Binding-protein-dependent transport system inner membrane component K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 592.0
TLS2_k127_678377_10 Binding-protein-dependent transport system inner membrane component K02038 - - 0.000000000005734 71.0
TLS2_k127_678377_2 PBP superfamily domain K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 413.0
TLS2_k127_678377_3 Transcriptional regulatory protein, C terminal K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008992 284.0
TLS2_k127_678377_4 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000001831 242.0
TLS2_k127_678377_5 Cobalamin synthesis protein cobW C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000005974 237.0
TLS2_k127_678377_6 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.000000000000000000000000000000000000004884 149.0
TLS2_k127_678377_7 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000007044 123.0
TLS2_k127_678377_8 Sulfatase K01138 - - 0.000000000000000000000524 110.0
TLS2_k127_678377_9 phosphoesterase, PA-phosphatase related - - - 0.0000000000000000001497 99.0
TLS2_k127_6787227_0 Rubrerythrin K22405 - 1.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 582.0
TLS2_k127_6787227_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 458.0
TLS2_k127_6787227_10 PFAM luciferase family protein - - - 0.00005403 47.0
TLS2_k127_6787227_11 AMP binding - - - 0.0009913 49.0
TLS2_k127_6787227_2 FIST C domain K01255,K01259 GO:0001073,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006351,GO:0006355,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009056,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016787,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019538,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0042150,GO:0043170,GO:0043171,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043244,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0097718,GO:0140096,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1903506,GO:2000112,GO:2001141 3.4.11.1,3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 424.0
TLS2_k127_6787227_3 fatty acid biosynthetic process K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000483 240.0
TLS2_k127_6787227_4 protein tyrosine kinase activity K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000001352 237.0
TLS2_k127_6787227_5 Selenoprotein B glycine betaine sarcosine D-proline reductase K10794 - 1.21.4.1 0.00000000000000000000000000000000000000000000000000000003715 200.0
TLS2_k127_6787227_6 - - - - 0.0000000000000000000000000000000001242 136.0
TLS2_k127_6787227_8 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000009046 103.0
TLS2_k127_6787227_9 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000002069 66.0
TLS2_k127_6788946_0 COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K12528 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008905 313.0
TLS2_k127_6788946_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01697,K21949 - 2.5.1.140,4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000002114 232.0
TLS2_k127_6788946_2 Haloacid dehalogenase-like hydrolase K01101 - 3.1.3.41 0.00000000000000000000000000000000000000000000000002615 188.0
TLS2_k127_6788946_3 Aerobic-type carbon monoxide dehydrogenase small subunit CoxS K13483 - - 0.000000000000000000000000000000000000000002033 160.0
TLS2_k127_6789029_0 Nucleotidyl transferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 383.0
TLS2_k127_6789029_1 N-acetylglucosaminylinositol deacetylase activity K18455 - 3.5.1.115 0.000000000000000000000000000000000000000000000000000000001232 212.0
TLS2_k127_6789029_2 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - - - 0.0000000000000000000000000000000000000000000000000003059 190.0
TLS2_k127_6789029_3 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.000000000000000000000000000000000001199 142.0
TLS2_k127_6789029_4 PFAM Class I peptide chain release factor K15034 - - 0.00000000000000000000000000000000001408 139.0
TLS2_k127_6789029_5 ABC-type transport system permease - - - 0.0000000000000000000000000001353 124.0
TLS2_k127_6807817_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 392.0
TLS2_k127_6807817_1 Belongs to the ABC transporter superfamily K02031,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 370.0
TLS2_k127_6807817_2 Fumarylacetoacetate (FAA) hydrolase family K01617,K02554 - 4.1.1.77,4.2.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000009536 262.0
TLS2_k127_6807817_3 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000001226 150.0
TLS2_k127_6807817_4 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.00000000000000000000000000005604 122.0
TLS2_k127_6807817_5 PFAM ROSMUCR transcriptional regulator - - - 0.000000000000000000000000000416 119.0
TLS2_k127_6809896_0 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 569.0
TLS2_k127_6809896_1 Chondroitinase B - - - 0.0000000000000000000000000000001577 141.0
TLS2_k127_6809896_2 oxidoreductase activity K07114 - - 0.0000000000000000003682 102.0
TLS2_k127_6809896_3 Nucleotidyltransferase domain K07076 - - 0.000000000000000002762 89.0
TLS2_k127_6809896_4 Protein of unknown function DUF86 - - - 0.000000000000001997 82.0
TLS2_k127_6809896_5 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000004847 57.0
TLS2_k127_6825953_0 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 625.0
TLS2_k127_6825953_1 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 436.0
TLS2_k127_6825953_2 - - - - 0.000000000000000000000000000186 119.0
TLS2_k127_6825953_3 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000001711 73.0
TLS2_k127_6838278_0 PFAM Bile acid sodium symporter K03325 - - 1.501e-195 617.0
TLS2_k127_6838278_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 383.0
TLS2_k127_6838278_10 Phosphorylase superfamily - - - 0.0000000000000001023 90.0
TLS2_k127_6838278_2 Male sterility protein K00091,K19997 - 1.1.1.219,5.1.3.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 377.0
TLS2_k127_6838278_3 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007696 362.0
TLS2_k127_6838278_4 Squalene-hopene cyclase C-terminal domain K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005348 318.0
TLS2_k127_6838278_5 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006256 304.0
TLS2_k127_6838278_6 Pfam:DUF422 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006874 255.0
TLS2_k127_6838278_7 low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000001797 198.0
TLS2_k127_6838278_8 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000000000000000000002167 193.0
TLS2_k127_6838278_9 PhoQ Sensor - - - 0.00000000000000000001476 98.0
TLS2_k127_6841828_0 rRNA (adenine-N6,N6-)-dimethyltransferase activity K00561,K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182,2.1.1.184 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 312.0
TLS2_k127_6841828_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001057 276.0
TLS2_k127_6841828_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000001212 199.0
TLS2_k127_6841828_3 cyclopropane-fatty-acyl-phospholipid synthase K00574,K07154,K14369,K15257,K18534 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0044237,GO:0044249 2.1.1.254,2.1.1.295,2.1.1.79,2.7.11.1 0.000000000000000000000000000000000004099 148.0
TLS2_k127_6841828_4 Psort location Cytoplasmic, score - - - 0.00000000000000000003485 93.0
TLS2_k127_6844892_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 394.0
TLS2_k127_6844892_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000001574 126.0
TLS2_k127_6844892_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000003529 66.0
TLS2_k127_6847265_0 Heat shock 70 kDa protein K04043 - - 2.04e-266 828.0
TLS2_k127_6847265_1 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000003367 154.0
TLS2_k127_6847265_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000005406 147.0
TLS2_k127_6847265_3 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000009526 118.0
TLS2_k127_6847265_4 Transcriptional regulator PadR-like family - - - 0.00000284 54.0
TLS2_k127_6868523_0 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 318.0
TLS2_k127_6868523_1 amidohydrolase K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000003708 249.0
TLS2_k127_6868523_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000004863 217.0
TLS2_k127_6868523_3 - - - - 0.0000000000000000000001016 100.0
TLS2_k127_6868523_4 EamA-like transporter family - - - 0.00000000000003688 81.0
TLS2_k127_6880853_0 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 485.0
TLS2_k127_6880853_1 photoreceptor activity - - - 0.000000000000000000000000000000000000000000000000000000002008 220.0
TLS2_k127_6880853_2 response regulator, receiver K02485 - - 0.000000000000000000000000000000000000001903 153.0
TLS2_k127_6880853_3 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000001603 101.0
TLS2_k127_6893962_0 Aminotransferase class-III K00833,K03851,K12256,K15372 - 2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 334.0
TLS2_k127_6893962_1 COG3119 Arylsulfatase A and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000639 319.0
TLS2_k127_6893962_2 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000001934 147.0
TLS2_k127_6893962_3 TIGRFAM methyltransferase - - - 0.00000004399 63.0
TLS2_k127_6904654_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 5.345e-295 912.0
TLS2_k127_6904654_1 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 365.0
TLS2_k127_6909306_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005573 478.0
TLS2_k127_6909306_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000305 281.0
TLS2_k127_6909306_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K13891 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006374 279.0
TLS2_k127_6909306_3 Extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000005777 215.0
TLS2_k127_6909306_4 PFAM Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000137 137.0
TLS2_k127_6914762_0 Glycosyltransferase like family 2 - - - 1.473e-267 833.0
TLS2_k127_6914762_1 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 2.466e-253 797.0
TLS2_k127_6914762_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 537.0
TLS2_k127_6914762_3 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05827,K05844 - 6.3.2.43 0.0000000000000000000000005006 115.0
TLS2_k127_6933570_0 Potassium uptake protein, TrkH family K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 469.0
TLS2_k127_6933570_1 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 397.0
TLS2_k127_6933570_2 PFAM TrkA-N domain protein K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004372 362.0
TLS2_k127_6933570_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K00068,K03366 - 1.1.1.100,1.1.1.140,1.1.1.304,1.1.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 312.0
TLS2_k127_6933570_4 Dihydrodipicolinate reductase, N-terminus K21672 - 1.4.1.12,1.4.1.26 0.000000000000000000000000000000000000000000000000000000000000000000002978 247.0
TLS2_k127_6933570_5 SIS domain K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000008895 171.0
TLS2_k127_6933570_6 MoaE protein K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.000000000000000000000000000000000000000005111 158.0
TLS2_k127_6933570_7 Regulatory protein, FmdB family - - - 0.000000000000000000000284 100.0
TLS2_k127_6933570_8 molybdopterin converting factor, subunit 1, non-archaeal K03636 - - 0.0000000000000821 74.0
TLS2_k127_6934673_0 PFAM Mo-co oxidoreductase dimerisation domain K17225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000827 252.0
TLS2_k127_6934673_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001577 238.0
TLS2_k127_6934673_2 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000001366 230.0
TLS2_k127_6934673_3 Cupin 2, conserved barrel domain protein - - - 0.00001192 52.0
TLS2_k127_6946121_0 PFAM Prolyl oligopeptidase family - - - 6.309e-301 933.0
TLS2_k127_6946121_1 Trehalose utilisation K15538,K21132 - 3.2.1.130,3.2.1.198 0.000000000000000000000000000000000000000000000000000000000191 215.0
TLS2_k127_6946121_2 Domain of unknown function (DUF4845) - - - 0.000000000001769 74.0
TLS2_k127_6946121_3 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.000000001901 68.0
TLS2_k127_6946121_4 transposase or invertase - - - 0.00002137 56.0
TLS2_k127_6963908_0 Tetratricopeptide repeat K11935 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003866 326.0
TLS2_k127_6963908_1 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 303.0
TLS2_k127_6963908_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000005007 244.0
TLS2_k127_6963908_3 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000007788 180.0
TLS2_k127_6963908_4 KAP family P-loop domain - - - 0.000000000000709 78.0
TLS2_k127_6963908_5 Protein of unknown function (DUF721) - - - 0.000000005181 64.0
TLS2_k127_6963908_6 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00003577 55.0
TLS2_k127_6975515_0 extracellular solute-binding protein, family 1 K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 321.0
TLS2_k127_6975515_1 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000001001 237.0
TLS2_k127_6975515_2 stress-induced mitochondrial fusion - - - 0.000000000000000000000000000000000000000000000000000000000005067 216.0
TLS2_k127_6975515_3 Pentapeptide repeats (8 copies) - - - 0.00000000000000000000000000000000000003533 159.0
TLS2_k127_6975515_4 Adenylyl- / guanylyl cyclase, catalytic domain K15352,K18555 - - 0.00000000000000000009982 100.0
TLS2_k127_6975515_5 ADP binding K01768 - 4.6.1.1 0.0000000001549 66.0
TLS2_k127_697759_0 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 2.445e-232 729.0
TLS2_k127_697759_1 Flavin containing amine oxidoreductase - - - 8.111e-223 701.0
TLS2_k127_697759_2 Aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000665 408.0
TLS2_k127_697759_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000007147 190.0
TLS2_k127_697759_5 Phosphate acyltransferases - - - 0.000000000002633 70.0
TLS2_k127_697759_6 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666 - - 0.00000001073 60.0
TLS2_k127_697759_7 - - - - 0.0000001939 60.0
TLS2_k127_6988962_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 321.0
TLS2_k127_6988962_1 carboxylic ester hydrolase activity K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 297.0
TLS2_k127_6988962_2 Thiamine pyrophosphate enzyme, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002236 283.0
TLS2_k127_6988962_3 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000234 153.0
TLS2_k127_6988962_4 COG0500 SAM-dependent methyltransferases - - - 0.0000000000000000000000000001218 116.0
TLS2_k127_6988962_5 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000000002502 106.0
TLS2_k127_6988962_6 Methyltransferase domain - - - 0.000000000000000000004757 95.0
TLS2_k127_6988962_7 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000001203 76.0
TLS2_k127_6993840_0 domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003573 271.0
TLS2_k127_7004945_2 Capsule biosynthesis CapC K22116 - - 0.00000000000000000000000000000000000000000000000000000000007933 224.0
TLS2_k127_7004945_3 - - - - 0.0000000000000000000000000000000000000000000000003894 189.0
TLS2_k127_7022092_0 Peptidase family M41 K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 597.0
TLS2_k127_7022092_1 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000007941 210.0
TLS2_k127_7022092_2 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K01856,K02549 - 4.2.1.113,5.5.1.1 0.00001242 49.0
TLS2_k127_705281_0 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009453 263.0
TLS2_k127_705281_2 Fe-S cluster assembly protein SufE K02426 - - 0.000000000000000000000000000000007578 132.0
TLS2_k127_705281_3 Selenoprotein B, glycine betaine sarcosine D-proline reductase family K10672 - 1.21.4.2 0.000000000000000006946 84.0
TLS2_k127_705281_4 - - - - 0.00000000003746 66.0
TLS2_k127_7083945_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 374.0
TLS2_k127_7083945_1 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001396 267.0
TLS2_k127_7083945_2 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000584 244.0
TLS2_k127_7083945_3 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000009972 238.0
TLS2_k127_7101570_0 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007355 553.0
TLS2_k127_7101570_1 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000002062 180.0
TLS2_k127_7101570_2 Phosphopantetheine attachment site - - - 0.000000000000000004418 86.0
TLS2_k127_7106075_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 1.637e-270 845.0
TLS2_k127_7106075_1 TIGRFAM methylmalonyl-CoA mutase, large subunit K01848 - 5.4.99.2 1.556e-205 649.0
TLS2_k127_7106075_10 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000851 158.0
TLS2_k127_7106075_11 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102,K07452 - 2.7.1.221 0.000000000000000000000000000005124 125.0
TLS2_k127_7106075_12 heme binding - - - 0.000000000000000000000000000007392 127.0
TLS2_k127_7106075_13 Regulatory protein - - - 0.0000000000000000000000006194 109.0
TLS2_k127_7106075_14 OstA-like protein K09774 - - 0.0000001654 61.0
TLS2_k127_7106075_15 lipopolysaccharide transmembrane transporter activity K09774,K11719 - - 0.00001554 54.0
TLS2_k127_7106075_16 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00001595 48.0
TLS2_k127_7106075_17 - - - - 0.00003926 48.0
TLS2_k127_7106075_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 456.0
TLS2_k127_7106075_3 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 444.0
TLS2_k127_7106075_4 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 415.0
TLS2_k127_7106075_5 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008946 399.0
TLS2_k127_7106075_6 K06861 lipopolysaccharide export system ATP-binding protein K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 302.0
TLS2_k127_7106075_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006203 303.0
TLS2_k127_7106075_8 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007229 290.0
TLS2_k127_7106075_9 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000001167 196.0
TLS2_k127_716265_0 ABC-type dipeptide transport system periplasmic component - - - 2.439e-224 707.0
TLS2_k127_716265_1 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 472.0
TLS2_k127_716265_2 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 432.0
TLS2_k127_716265_3 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 404.0
TLS2_k127_7164089_0 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 546.0
TLS2_k127_7164089_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000001593 207.0
TLS2_k127_7164089_2 - - - - 0.000000000000000000000000000000000000000000000000000006149 195.0
TLS2_k127_7164089_4 Haloacid dehalogenase-like hydrolase K01101 - 3.1.3.41 0.00000000000000000000005398 102.0
TLS2_k127_717457_0 monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 576.0
TLS2_k127_717457_1 Belongs to the LDH2 MDH2 oxidoreductase family K13609,K16844 - 1.1.1.338,1.5.1.21 0.000000000000000000000000000000001721 132.0
TLS2_k127_717457_2 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.00000000000000000000001109 111.0
TLS2_k127_7222834_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1073.0
TLS2_k127_7222834_1 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 546.0
TLS2_k127_7222834_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K19595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 327.0
TLS2_k127_7222834_3 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000001332 165.0
TLS2_k127_7232_0 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000006147 268.0
TLS2_k127_7232_1 nucleotide metabolic process - - - 0.0000000000000000000000000000000000000000000001354 177.0
TLS2_k127_7232_2 FHA domain K07315 - 3.1.3.3 0.000000000000000000001882 101.0
TLS2_k127_7232_3 phosphatase K14165 - 3.1.3.16,3.1.3.48 0.0000000000000000001561 96.0
TLS2_k127_7232_4 Belongs to the peptidase S8 family - - - 0.0000000000000108 87.0
TLS2_k127_7235312_0 aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 595.0
TLS2_k127_7235312_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009196 556.0
TLS2_k127_7235312_2 aspartate-semialdehyde dehydrogenase K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 423.0
TLS2_k127_7261366_0 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001865 284.0
TLS2_k127_7261366_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000001126 253.0
TLS2_k127_7298877_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 423.0
TLS2_k127_7298877_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000002438 123.0
TLS2_k127_7299393_0 COG0044 Dihydroorotase and related cyclic amidohydrolases - - - 1.435e-238 744.0
TLS2_k127_7299393_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000189 231.0
TLS2_k127_7299393_2 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000002607 101.0
TLS2_k127_7317098_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 1.384e-203 644.0
TLS2_k127_7317098_1 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003146 395.0
TLS2_k127_7317098_10 Universal stress protein family - - - 0.000000008372 63.0
TLS2_k127_7317098_2 Thiamine pyrophosphate enzyme, central K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 387.0
TLS2_k127_7317098_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 349.0
TLS2_k127_7317098_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001139 239.0
TLS2_k127_7317098_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000007742 234.0
TLS2_k127_7317098_6 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000006083 224.0
TLS2_k127_7317098_7 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000002484 208.0
TLS2_k127_7317098_8 PFAM tRNA synthetase class II (D K and N) K01893 - 6.1.1.22 0.000000000000000000000000000194 114.0
TLS2_k127_7317098_9 NAD-dependent protein deacetylase K11416 GO:0006325,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016569,GO:0016570,GO:0016573,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0043966,GO:0043970,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051276,GO:0061647,GO:0071704,GO:0071840,GO:1901564 2.4.2.31 0.000000000644 61.0
TLS2_k127_7349967_0 - - - - 1.926e-302 936.0
TLS2_k127_7349967_1 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 7.935e-278 869.0
TLS2_k127_7349967_2 COG0457 FOG TPR repeat - - - 0.0000000000000000004619 100.0
TLS2_k127_7349967_3 Conserved hypothetical protein (Lin0512_fam) - - - 0.000006057 49.0
TLS2_k127_7355124_0 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 305.0
TLS2_k127_7355124_1 Domain of unknown function (DUF3390) K18929 - - 0.000000000000000000000000000000000000000000000000004555 185.0
TLS2_k127_7355124_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000372 149.0
TLS2_k127_7355124_3 LUD domain K00782 - - 0.0000000000000000000000000000000008572 140.0
TLS2_k127_7355124_4 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000006425 118.0
TLS2_k127_7355124_5 Acyl dehydratase - - - 0.000000000648 65.0
TLS2_k127_7416168_0 TIGRFAM LPPG domain protein containing protein K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 334.0
TLS2_k127_7416168_1 TIGRFAM F420-dependent oxidoreductase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004587 286.0
TLS2_k127_7416168_2 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000001144 219.0
TLS2_k127_7416168_3 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000000000000000000000001373 144.0
TLS2_k127_7416168_4 COG1233 Phytoene dehydrogenase and related - - - 0.000000000000000000000000000136 117.0
TLS2_k127_7428055_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.819e-255 809.0
TLS2_k127_7428055_1 C terminal of Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 591.0
TLS2_k127_7428055_2 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 396.0
TLS2_k127_7428055_3 methyltransferase activity - - - 0.0000000000003006 76.0
TLS2_k127_7441651_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K17883 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0010126,GO:0016137,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050627,GO:0050660,GO:0050661,GO:0050662,GO:0051186,GO:0055114,GO:0070402,GO:0071704,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901657 1.8.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006702 461.0
TLS2_k127_7441651_1 F420-dependent oxidoreductase, MSMEG_3544 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 355.0
TLS2_k127_7441651_2 Redoxin - - - 0.000000000000000002593 88.0
TLS2_k127_7441651_3 Thioredoxin-like - - - 0.000000002554 60.0
TLS2_k127_7441651_4 - - - - 0.000000007755 65.0
TLS2_k127_7441651_5 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000009252 51.0
TLS2_k127_7465788_0 Subtilase family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008127 553.0
TLS2_k127_7465788_1 DEAD DEAH box helicase K06877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 322.0
TLS2_k127_752423_0 unusual protein kinase K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 422.0
TLS2_k127_752423_1 Putative restriction endonuclease - - - 0.000000000000000000006397 98.0
TLS2_k127_752423_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000159 74.0
TLS2_k127_752423_3 pfam abc1 K03688 - - 0.0002543 44.0
TLS2_k127_76000_0 PFAM Type II secretion system protein E K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 598.0
TLS2_k127_76000_1 Type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 451.0
TLS2_k127_76000_2 General secretion pathway protein F K02455,K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 360.0
TLS2_k127_76000_3 SMART AAA ATPase K02450 - - 0.0000000000000000001747 101.0
TLS2_k127_76000_4 PFAM Tetratricopeptide repeat - - - 0.000000000000000009037 94.0
TLS2_k127_76000_5 Domain present in PSD-95, Dlg, and ZO-1/2. K02452 - - 0.00000000000994 76.0
TLS2_k127_76000_6 Fimbrial assembly family protein K02461 - - 0.0000000005377 72.0
TLS2_k127_76155_0 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 368.0
TLS2_k127_76155_1 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000003181 67.0
TLS2_k127_76155_2 Putative glutamine amidotransferase K07114 - - 0.0000000002027 68.0
TLS2_k127_761855_0 Pantothenic acid kinase K00867 GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 396.0
TLS2_k127_761855_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 299.0
TLS2_k127_761855_2 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000008447 205.0
TLS2_k127_76434_0 PFAM AMP-dependent synthetase and ligase K01904 - 6.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 423.0
TLS2_k127_76434_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00015 - 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 352.0
TLS2_k127_76434_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000008373 142.0
TLS2_k127_77848_0 ABC transporter, transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003351 552.0
TLS2_k127_77848_1 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01032 - 2.8.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 289.0
TLS2_k127_77848_2 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01034 - 2.8.3.8,2.8.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000008895 263.0
TLS2_k127_77848_3 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000002174 230.0
TLS2_k127_77848_4 PFAM ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000003051 182.0
TLS2_k127_800725_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K00179 - 1.2.7.8 0.0 1106.0
TLS2_k127_800725_1 Glycosyl transferase family 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 377.0
TLS2_k127_800725_10 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000001527 128.0
TLS2_k127_800725_11 Domain of unkown function (DUF1775) - - - 0.0000000366 63.0
TLS2_k127_800725_12 Rhodanese-like domain - - - 0.00000008343 59.0
TLS2_k127_800725_13 COG0607 Rhodanese-related sulfurtransferase - - - 0.00002533 48.0
TLS2_k127_800725_2 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 359.0
TLS2_k127_800725_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 338.0
TLS2_k127_800725_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 299.0
TLS2_k127_800725_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000152 203.0
TLS2_k127_800725_6 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000000000001834 176.0
TLS2_k127_800725_7 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000111 178.0
TLS2_k127_800725_8 NUDIX domain - - - 0.0000000000000000000000000000000000000000000002464 173.0
TLS2_k127_800725_9 SET domain K07117 - - 0.000000000000000000000000000000000000008246 153.0
TLS2_k127_805388_0 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000001602 252.0
TLS2_k127_805388_1 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000001216 139.0
TLS2_k127_805388_2 chaperone-mediated protein folding - - - 0.00000000000000000000006738 104.0
TLS2_k127_805388_3 ECF sigma factor K03088 - - 0.000000000000003545 85.0
TLS2_k127_805388_4 VanZ like family - - - 0.0000002443 58.0
TLS2_k127_807538_0 Transposase K07487 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 312.0
TLS2_k127_807538_1 COG0258 5'-3' exonuclease (including N-terminal domain of PolI) - - - 0.0000000000000000000000000000000000000000000000000000000000000000004084 240.0
TLS2_k127_807538_2 AMP binding - - - 0.00000000000000004814 92.0
TLS2_k127_807538_3 PFAM ROSMUCR transcriptional regulator - - - 0.0000000000009054 71.0
TLS2_k127_81259_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.000000000000000000000000000000000000000000000000001505 192.0
TLS2_k127_81259_1 O-Antigen ligase K18814 - - 0.000000000000000000000000000003887 134.0
TLS2_k127_816510_0 synthase - - - 1.993e-208 679.0
TLS2_k127_819774_0 L-allo-threonine aldolase activity K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 374.0
TLS2_k127_819774_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003791 377.0
TLS2_k127_819774_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000435 338.0
TLS2_k127_819774_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009646 288.0
TLS2_k127_819774_4 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000000000000000000003161 195.0
TLS2_k127_819774_5 Belongs to the SfsA family K06206 - - 0.000000000000000001427 96.0
TLS2_k127_828418_0 DnaB-like helicase N terminal domain K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 372.0
TLS2_k127_828418_1 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000002515 137.0
TLS2_k127_828418_2 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000004887 110.0
TLS2_k127_828418_3 Predicted membrane protein (DUF2232) - - - 0.000000000000000001538 96.0
TLS2_k127_828418_4 Single-strand binding protein family K03111 - - 0.000000000000002482 79.0
TLS2_k127_872220_0 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003405 261.0
TLS2_k127_872220_1 MaoC like domain - - - 0.0000000000000000000000000000000000000000000000000000000000008208 213.0
TLS2_k127_872220_2 carboxylic ester hydrolase activity K08680 - 4.2.99.20 0.000000000000000000000000000000000000000000000129 178.0
TLS2_k127_872220_3 phosphinothricin N-acetyltransferase activity - - - 0.0000000000000000000000009676 113.0
TLS2_k127_872220_4 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000009172 66.0
TLS2_k127_879604_0 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000004284 219.0
TLS2_k127_879604_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000008566 221.0
TLS2_k127_879604_2 - - - - 0.000000000000000003151 94.0
TLS2_k127_888392_0 binding domain protein K07138 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 328.0
TLS2_k127_888392_1 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000001039 200.0
TLS2_k127_88881_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004671 277.0
TLS2_k127_88881_1 regulation of cobalamin metabolic process K11390 GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0008150,GO:0009987,GO:0016043,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0019222,GO:0022607,GO:0030656,GO:0031323,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046912,GO:0047777,GO:0050789,GO:0050794,GO:0051171,GO:0051193,GO:0051259,GO:0051260,GO:0062012,GO:0065003,GO:0065007,GO:0070206,GO:0070207,GO:0071840,GO:0106064,GO:1901401 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009386 266.0
TLS2_k127_88881_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006325 259.0
TLS2_k127_88881_3 transcriptional regulator - - - 0.00000009592 61.0
TLS2_k127_890429_0 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009371 392.0
TLS2_k127_890429_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000005414 165.0
TLS2_k127_890429_2 Beta-ketoacyl synthase, C-terminal domain K18473 - 2.3.1.180 0.000000000000000000000000000000000000000008516 158.0
TLS2_k127_890429_3 peroxiredoxin activity K01607 - 4.1.1.44 0.000000000000000000000000000001788 125.0
TLS2_k127_899038_0 Beta-ketoacyl synthase - - - 5.566e-194 617.0
TLS2_k127_899038_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000008835 106.0
TLS2_k127_903586_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 565.0
TLS2_k127_903586_1 Gamma-glutamyltranspeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 435.0
TLS2_k127_903586_2 FR47-like protein - - - 0.000000000000000000000000002537 117.0
TLS2_k127_903586_3 Berberine and berberine like - - - 0.00000000000000000000128 96.0
TLS2_k127_903586_4 - - - - 0.000001882 59.0
TLS2_k127_90520_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000005113 257.0
TLS2_k127_90520_1 DsrE/DsrF-like family - - - 0.000000000000000000000000000000000000000000001292 173.0
TLS2_k127_90520_2 Belongs to the sulfur carrier protein TusA family - - - 0.000000000000005147 77.0
TLS2_k127_910696_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004381 267.0
TLS2_k127_910696_1 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000004582 162.0
TLS2_k127_910696_2 - - - - 0.00000001525 60.0
TLS2_k127_910696_3 - - - - 0.000003965 49.0
TLS2_k127_913016_0 GMC oxidoreductase K00108 - 1.1.99.1 3.695e-281 872.0
TLS2_k127_913016_1 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 451.0
TLS2_k127_913016_2 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000003496 129.0
TLS2_k127_92012_0 Protein of unknown function (DUF3616) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002929 387.0
TLS2_k127_92012_1 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 308.0
TLS2_k127_92012_2 Zn-dependent hydrolases of the beta-lactamase fold - - - 0.0000000000000000000000000000000000000000000004949 169.0
TLS2_k127_92012_3 COGs COG1680 Beta-lactamase class C and other penicillin binding protein - - - 0.000000000000000000000000000000000000001686 151.0
TLS2_k127_92012_4 Right handed beta helix region - - - 0.0001634 53.0
TLS2_k127_92790_0 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000469 331.0
TLS2_k127_92790_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000015 210.0
TLS2_k127_92790_2 COG3221 ABC-type phosphate phosphonate transport system, periplasmic component K02044 - - 0.000000000000000000000000000000000000000000883 160.0
TLS2_k127_92790_3 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000000006495 149.0
TLS2_k127_92790_4 cheY-homologous receiver domain K02485 - - 0.00000000004577 64.0
TLS2_k127_933030_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K19837 - 3.5.1.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 404.0
TLS2_k127_933030_1 HD domain K07023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000139 265.0
TLS2_k127_933030_2 ROS/MUCR transcriptional regulator protein - - - 0.00000000000000005692 88.0
TLS2_k127_93314_0 GAF domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 558.0
TLS2_k127_93314_1 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 396.0
TLS2_k127_93314_2 chaperone-mediated protein folding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003543 268.0
TLS2_k127_93314_3 haemagglutination activity domain - - - 0.0000000000000000000000000000000000000000000000000000002334 215.0
TLS2_k127_93314_4 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000005048 73.0
TLS2_k127_93314_5 filamentous hemagglutinin family N-terminal domain - - - 0.0000000002861 72.0
TLS2_k127_93314_6 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 0.00001893 50.0
TLS2_k127_935895_0 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001389 280.0
TLS2_k127_935895_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000001458 104.0
TLS2_k127_94324_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 2.541e-201 651.0
TLS2_k127_94324_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 400.0
TLS2_k127_94324_2 carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 348.0
TLS2_k127_94324_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000217 121.0
TLS2_k127_94324_4 Asp/Glu/Hydantoin racemase K16841 - 5.1.99.3 0.00000000000000000000007794 108.0
TLS2_k127_94324_5 - - - - 0.00000003972 60.0
TLS2_k127_964335_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 5.264e-220 691.0
TLS2_k127_964335_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 541.0
TLS2_k127_964335_2 PFAM Integrase core domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 340.0
TLS2_k127_964335_3 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003907 282.0
TLS2_k127_964335_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000691 236.0
TLS2_k127_964335_5 ATPase binding K03600,K09985 GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - 0.0000000000000000000000000309 114.0
TLS2_k127_964335_6 Transposase K07483 - - 0.000002057 49.0
TLS2_k127_970919_0 polyketide synthase - - - 5.369e-247 792.0
TLS2_k127_970919_1 polyketide synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 406.0
TLS2_k127_970919_2 Outer membrane lipoprotein-sorting protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006177 283.0
TLS2_k127_970919_3 - - - - 0.00000000000000000000000000000000000000000000929 168.0
TLS2_k127_970919_4 - - - - 0.0000000000000000000000000001135 120.0
TLS2_k127_985785_0 COG1305 Transglutaminase-like enzymes K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 431.0
TLS2_k127_985785_1 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000006669 177.0
TLS2_k127_996646_0 UvrD/REP helicase N-terminal domain - - - 5.981e-198 640.0
TLS2_k127_996646_1 SAF - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002939 578.0
TLS2_k127_996646_2 PFAM YebG family protein K09918 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010165,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000002444 94.0
TLS2_k127_996646_3 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000001309 66.0