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Overview

ID MAG03982
Name TLS2_bin.10
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Sphingomonadales
Family Sphingomonadaceae
Genus Allosphingosinicella
Species
Assembly information
Completeness (%) 61.95
Contamination (%) 1.17
GC content (%) 68.0
N50 (bp) 9,928
Genome size (bp) 1,778,470

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1836

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1008194_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850,K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 535.0
TLS2_k127_1008194_1 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 458.0
TLS2_k127_1008194_2 cell division K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009039 387.0
TLS2_k127_1008194_3 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003543 295.0
TLS2_k127_1008194_4 Cell division protein K09811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002288 295.0
TLS2_k127_1008194_5 beta-N-acetylglucosaminidase - - - 0.0000000000000000000000000000000000000000000000000000000000000003136 237.0
TLS2_k127_1008194_6 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000003069 190.0
TLS2_k127_1008194_7 zinc-ribbon domain - - - 0.00000000000000000002611 106.0
TLS2_k127_1025639_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1356.0
TLS2_k127_1025639_1 protein conserved in bacteria - - - 1.68e-225 716.0
TLS2_k127_1025639_2 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 319.0
TLS2_k127_1025639_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000004639 196.0
TLS2_k127_1025639_4 SnoaL-like domain K06893 - - 0.00000000000000000000000000000000000000003887 158.0
TLS2_k127_1025639_5 Dodecin K09165 - - 0.0000000000000000000000000113 111.0
TLS2_k127_1025639_6 - - - - 0.0000000000000000000001035 103.0
TLS2_k127_1025639_7 - - - - 0.0000000000000000000005098 102.0
TLS2_k127_1025639_8 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000009858 104.0
TLS2_k127_1025639_9 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.000002725 49.0
TLS2_k127_1033679_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 8.539e-265 826.0
TLS2_k127_1033679_1 Heparinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009711 481.0
TLS2_k127_1033679_2 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 368.0
TLS2_k127_1033679_3 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000004495 205.0
TLS2_k127_104399_0 chemotaxis protein K03407 - 2.7.13.3 1.126e-267 845.0
TLS2_k127_104399_1 acyl-CoA dehydrogenase K00249,K00255 - 1.3.8.7,1.3.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 600.0
TLS2_k127_104399_10 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000000000000000000002237 205.0
TLS2_k127_104399_11 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000008798 198.0
TLS2_k127_104399_12 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000001081 152.0
TLS2_k127_104399_13 - - - - 0.0000000000000002947 85.0
TLS2_k127_104399_14 SufE protein probably involved in Fe-S center assembly K02426 - - 0.00000000000004821 72.0
TLS2_k127_104399_16 Cupin domain - - - 0.000001973 58.0
TLS2_k127_104399_2 L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 434.0
TLS2_k127_104399_3 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006133 366.0
TLS2_k127_104399_4 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 349.0
TLS2_k127_104399_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 348.0
TLS2_k127_104399_6 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007923 321.0
TLS2_k127_104399_7 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006922 270.0
TLS2_k127_104399_8 Belongs to the UPF0178 family K09768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000306 249.0
TLS2_k127_104399_9 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000000000000000000000000000000000000000003253 213.0
TLS2_k127_107201_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0 1047.0
TLS2_k127_107201_1 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 9.433e-258 815.0
TLS2_k127_107201_10 synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 367.0
TLS2_k127_107201_11 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 347.0
TLS2_k127_107201_12 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000001002 229.0
TLS2_k127_107201_13 Iron-sulfur cluster assembly protein K02612 - - 0.0000000000000000000000000000000000000000000000000000000000004282 217.0
TLS2_k127_107201_14 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000002286 183.0
TLS2_k127_107201_15 Phenylacetic acid degradation B K02610 - - 0.0000000000000000000000000000008202 121.0
TLS2_k127_107201_16 Protein of unknwon function (DUF3008) - - - 0.00000000000000000000000528 103.0
TLS2_k127_107201_17 EF hand - - - 0.00000000000000000645 92.0
TLS2_k127_107201_2 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 578.0
TLS2_k127_107201_3 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) K01484 - 3.5.3.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006909 592.0
TLS2_k127_107201_4 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002347 537.0
TLS2_k127_107201_5 Oxidoreductase FAD-binding domain K00523,K02613 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 480.0
TLS2_k127_107201_6 Caspase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 481.0
TLS2_k127_107201_7 arginine N-succinyltransferase K00673 - 2.3.1.109 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 449.0
TLS2_k127_107201_8 PFAM Alpha beta hydrolase fold-3 domain protein K01066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 411.0
TLS2_k127_107201_9 beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 378.0
TLS2_k127_1072115_0 Type II secretion system protein D K02453 - - 2.089e-251 793.0
TLS2_k127_1072115_1 General secretion pathway protein E K02454 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 396.0
TLS2_k127_1086216_0 glutamate--cysteine ligase K01919 - 6.3.2.2 2.153e-238 743.0
TLS2_k127_1086216_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 1.396e-201 633.0
TLS2_k127_1086216_10 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 394.0
TLS2_k127_1086216_11 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 375.0
TLS2_k127_1086216_12 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 336.0
TLS2_k127_1086216_13 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 342.0
TLS2_k127_1086216_14 Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001096 273.0
TLS2_k127_1086216_15 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001847 277.0
TLS2_k127_1086216_16 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000006389 235.0
TLS2_k127_1086216_17 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000000008283 186.0
TLS2_k127_1086216_18 PilZ domain - - - 0.0000000000000000000000000000000000000000000000002126 183.0
TLS2_k127_1086216_19 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000000000000000008775 172.0
TLS2_k127_1086216_2 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 599.0
TLS2_k127_1086216_20 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000001645 145.0
TLS2_k127_1086216_21 Protein of unknown function (DUF3035) - - - 0.00000000000000000000000000000000001248 139.0
TLS2_k127_1086216_22 Peptidase C14 caspase catalytic subunit p20 - - - 0.000000000000000000000000001761 121.0
TLS2_k127_1086216_23 Transcription factor zinc-finger K09981 - - 0.00000000000000000000000003053 117.0
TLS2_k127_1086216_24 - - - - 0.00000000000404 71.0
TLS2_k127_1086216_3 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 567.0
TLS2_k127_1086216_4 protein-S-isoprenylcysteine methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 558.0
TLS2_k127_1086216_5 cystathionine beta-lyase K01760 - 4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 539.0
TLS2_k127_1086216_6 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 494.0
TLS2_k127_1086216_7 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004124 434.0
TLS2_k127_1086216_8 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 401.0
TLS2_k127_1086216_9 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 399.0
TLS2_k127_1113529_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 2.947e-268 852.0
TLS2_k127_1113529_1 Radical SAM superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 386.0
TLS2_k127_1113529_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000004938 245.0
TLS2_k127_1113529_3 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000001385 215.0
TLS2_k127_1113529_4 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000000000000000000000000002196 207.0
TLS2_k127_1113529_5 Glycosyl transferase group 2 family protein - - - 0.00000000000000000000000000000000003057 140.0
TLS2_k127_1113529_6 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000415 76.0
TLS2_k127_1128458_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 393.0
TLS2_k127_1128458_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000003397 191.0
TLS2_k127_1128458_2 MerR HTH family regulatory protein - - - 0.00000000000000000000000000000000001273 140.0
TLS2_k127_113816_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000671 553.0
TLS2_k127_113816_1 Carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 397.0
TLS2_k127_113816_10 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000000000005482 151.0
TLS2_k127_113816_11 Bacterial PH domain K09167 - - 0.00000000000000000000000000000001121 138.0
TLS2_k127_113816_12 Histone methylation protein DOT1 - - - 0.000000000000000000000000000005902 124.0
TLS2_k127_113816_13 Type II secretion system (T2SS), protein I K02458 - - 0.00000000000000000000000000001284 127.0
TLS2_k127_113816_14 general secretion pathway protein K02457 - - 0.0000000000000000000001437 103.0
TLS2_k127_113816_15 nucleoside K03317 - - 0.0005491 44.0
TLS2_k127_113816_2 Type II secretion system protein K K02460 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 310.0
TLS2_k127_113816_3 Bacterial PH domain K08981 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 310.0
TLS2_k127_113816_4 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005373 273.0
TLS2_k127_113816_5 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008146 274.0
TLS2_k127_113816_6 Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002423 256.0
TLS2_k127_113816_7 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000006419 263.0
TLS2_k127_113816_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000004548 234.0
TLS2_k127_113816_9 General secretion pathway protein K02459 - - 0.00000000000000000000000000000000000000000006976 172.0
TLS2_k127_1148298_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.68e-312 964.0
TLS2_k127_1148298_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000007395 204.0
TLS2_k127_1148298_2 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000001708 149.0
TLS2_k127_1179994_0 DNA recombination protein K09760 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 499.0
TLS2_k127_1179994_1 META domain - - - 0.0000000000009751 69.0
TLS2_k127_1192548_0 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 346.0
TLS2_k127_1192548_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000988 171.0
TLS2_k127_1192548_2 Adenylate cyclase - - - 0.00000000000000000000000000000000000004352 160.0
TLS2_k127_1192548_3 - - - - 0.000000000000000000000000000000002482 137.0
TLS2_k127_1192548_4 Histidine kinase - - - 0.00000000000000000000002872 103.0
TLS2_k127_124963_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1357.0
TLS2_k127_124963_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 469.0
TLS2_k127_124963_2 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000001364 191.0
TLS2_k127_124963_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000002806 190.0
TLS2_k127_124963_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000003134 171.0
TLS2_k127_124963_5 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000003162 86.0
TLS2_k127_1257402_0 Dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 411.0
TLS2_k127_1257402_1 type I secretion membrane fusion protein K12542 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 297.0
TLS2_k127_1257402_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000003796 162.0
TLS2_k127_1257402_3 Small integral membrane protein - - - 0.000000000000000000000000000000003445 136.0
TLS2_k127_1257402_4 - - - - 0.00000000000000000000000000000007719 142.0
TLS2_k127_1257402_6 - - - - 0.0000000001325 71.0
TLS2_k127_1258171_0 PFAM AMP-dependent synthetase and ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 544.0
TLS2_k127_1258171_1 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002412 278.0
TLS2_k127_1258171_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000001031 191.0
TLS2_k127_1258171_3 Nudix hydrolase - - - 0.0000000000000000000000000000000000000000000000001215 181.0
TLS2_k127_1260480_0 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 424.0
TLS2_k127_1260480_1 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000004935 164.0
TLS2_k127_1260480_2 MerR, DNA binding K13639 - - 0.000000000001463 72.0
TLS2_k127_1263603_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 8.986e-232 727.0
TLS2_k127_1263603_1 of the beta-lactamase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009505 412.0
TLS2_k127_1263603_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000222 186.0
TLS2_k127_1263603_3 COG1734 DnaK suppressor protein K06204 - - 0.000000000000000000000000001021 116.0
TLS2_k127_1263603_4 Protein of unknown function (DUF3617) - - - 0.00000000000000000000000009426 112.0
TLS2_k127_1263603_5 - - - - 0.000000000000000001634 98.0
TLS2_k127_1263603_6 Protein of unknown function (DUF3617) - - - 0.00000000000000002031 93.0
TLS2_k127_1263603_7 Protein of unknown function (DUF3617) - - - 0.0000000000001431 74.0
TLS2_k127_1263603_8 Protein of unknown function (DUF3617) - - - 0.000000000003146 74.0
TLS2_k127_1270058_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.716e-295 912.0
TLS2_k127_1270058_1 metallo-beta-lactamase K12574 - - 1.813e-259 808.0
TLS2_k127_1270058_10 peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000888 423.0
TLS2_k127_1270058_11 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 342.0
TLS2_k127_1270058_12 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 327.0
TLS2_k127_1270058_13 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000546 314.0
TLS2_k127_1270058_14 with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000003481 265.0
TLS2_k127_1270058_15 - - - - 0.000000000000000000000000000000000000000000000000000000000000000008773 239.0
TLS2_k127_1270058_16 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.0000000000000000000000000000000000000000000000000000000000000123 229.0
TLS2_k127_1270058_17 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001916 215.0
TLS2_k127_1270058_18 Protein of unknown function (DUF3137) - - - 0.00000000000000000000000000000000000000003287 166.0
TLS2_k127_1270058_19 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000001496 162.0
TLS2_k127_1270058_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.656e-246 766.0
TLS2_k127_1270058_20 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000000000000000000000000000000000005608 150.0
TLS2_k127_1270058_21 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000000004824 155.0
TLS2_k127_1270058_22 - - - - 0.00000000000000000000000000000000007266 136.0
TLS2_k127_1270058_23 Protein of unknown function (DUF3833) - - - 0.0000000000000000000000000000007185 127.0
TLS2_k127_1270058_24 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.00000000000000000000000000002382 124.0
TLS2_k127_1270058_25 Preprotein translocase subunit SecG K03075 - - 0.0000000000000000000000000002836 118.0
TLS2_k127_1270058_26 Protein of unknown function (DUF1467) - - - 0.000000000000000000000000003705 114.0
TLS2_k127_1270058_27 Cold-shock protein K03704 - - 0.000000000000000000000000006809 110.0
TLS2_k127_1270058_28 Cold-shock protein K03704 - - 0.0000000000000000000000002371 109.0
TLS2_k127_1270058_29 DNA polymerase K02337 - 2.7.7.7 0.0000000000000000000000006734 107.0
TLS2_k127_1270058_3 membrane metal-binding protein K02238 - - 2.021e-239 759.0
TLS2_k127_1270058_30 - - - - 0.00000000000000000002101 93.0
TLS2_k127_1270058_31 Protein of unknown function (DUF1328) - - - 0.0000000000000002114 79.0
TLS2_k127_1270058_32 - - - - 0.000000000864 64.0
TLS2_k127_1270058_4 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 4.925e-207 651.0
TLS2_k127_1270058_5 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.025e-199 658.0
TLS2_k127_1270058_6 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 574.0
TLS2_k127_1270058_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007301 505.0
TLS2_k127_1270058_8 nuclear chromosome segregation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 497.0
TLS2_k127_1270058_9 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 414.0
TLS2_k127_1447807_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1195.0
TLS2_k127_1447807_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1194.0
TLS2_k127_1447807_10 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 306.0
TLS2_k127_1447807_11 Riboflavin synthase K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 291.0
TLS2_k127_1447807_12 RpsU-divergently transcribed K18587 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005765 257.0
TLS2_k127_1447807_13 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000000005503 219.0
TLS2_k127_1447807_14 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000000002431 215.0
TLS2_k127_1447807_15 Small protein A (tmRNA-binding) - - - 0.00000000000000000000000000000000000000000000000000000003701 203.0
TLS2_k127_1447807_16 Ubiquinol-cytochrome C chaperone K17662 - - 0.0000000000000000000000000000000000000000000007804 171.0
TLS2_k127_1447807_17 Uncharacterized ACR, COG1399 - - - 0.000000000000000000000000000000000000000000002231 178.0
TLS2_k127_1447807_18 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000000000000000000000000006938 136.0
TLS2_k127_1447807_19 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000000000000000000000000004578 128.0
TLS2_k127_1447807_2 Malic enzyme K00029 - 1.1.1.40 0.0 1184.0
TLS2_k127_1447807_20 - - - - 0.000001579 60.0
TLS2_k127_1447807_3 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 8.85e-300 932.0
TLS2_k127_1447807_4 permease K07243 - - 1.811e-210 675.0
TLS2_k127_1447807_5 Tetratricopeptide repeat - - - 5.838e-199 636.0
TLS2_k127_1447807_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 9.216e-198 624.0
TLS2_k127_1447807_7 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 601.0
TLS2_k127_1447807_8 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005665 522.0
TLS2_k127_1447807_9 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 424.0
TLS2_k127_1450174_0 ABC-type multidrug transport system, ATPase and permease K06147 - - 1.273e-236 740.0
TLS2_k127_1450174_1 Biopolymer K03559 - - 0.0000000000000000000000000000000000000000000000000000000000001538 216.0
TLS2_k127_1450174_2 Biopolymer transport protein K03559 - - 0.0000000000000000000000000000000000000000000000000000001567 197.0
TLS2_k127_145926_0 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003626 507.0
TLS2_k127_145926_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 407.0
TLS2_k127_1493936_0 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 596.0
TLS2_k127_1493936_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 434.0
TLS2_k127_1493936_10 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.0000000000000000000000000000000000000000000002492 188.0
TLS2_k127_1493936_11 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.0000000000000000000000000000001661 135.0
TLS2_k127_1493936_12 integral membrane protein K02221 - - 0.0000000000000000000000000008109 117.0
TLS2_k127_1493936_2 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000608 430.0
TLS2_k127_1493936_3 sugar transferase K20997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 400.0
TLS2_k127_1493936_4 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001498 286.0
TLS2_k127_1493936_5 adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000001157 258.0
TLS2_k127_1493936_6 Belongs to the glycosyltransferase 26 family K05946 - 2.4.1.187 0.000000000000000000000000000000000000000000000000000000000000000000000000001526 263.0
TLS2_k127_1493936_7 Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000007339 222.0
TLS2_k127_1493936_8 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000007566 186.0
TLS2_k127_1493936_9 COG3307 Lipid A core - O-antigen ligase and related enzymes - - - 0.0000000000000000000000000000000000000000000001916 184.0
TLS2_k127_1503479_0 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 504.0
TLS2_k127_1503479_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000008609 228.0
TLS2_k127_1503479_2 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000006109 137.0
TLS2_k127_1546280_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 4.253e-235 748.0
TLS2_k127_1546280_1 Chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 413.0
TLS2_k127_1546280_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009102 419.0
TLS2_k127_1546280_3 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002725 257.0
TLS2_k127_1546280_4 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000000000003538 236.0
TLS2_k127_1561975_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 574.0
TLS2_k127_1561975_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000000000000000000000000000000000000000000001138 200.0
TLS2_k127_1561975_2 - - - - 0.00000000000000000000000000000000001559 143.0
TLS2_k127_1561975_3 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.000000000000000000006433 93.0
TLS2_k127_1658938_0 amino acid K03294 - - 5.044e-271 842.0
TLS2_k127_1658938_1 alanine symporter K03310 - - 5.955e-227 713.0
TLS2_k127_1658938_10 Protein of unknown function (DUF1697) - - - 0.000000000009657 66.0
TLS2_k127_1658938_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.335e-209 660.0
TLS2_k127_1658938_3 Protein conserved in bacteria - - - 2.914e-207 661.0
TLS2_k127_1658938_4 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 501.0
TLS2_k127_1658938_5 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 328.0
TLS2_k127_1658938_6 protein conserved in bacteria K09985 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003309 262.0
TLS2_k127_1658938_7 Protein of unknown function (DUF2585) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004541 253.0
TLS2_k127_1658938_8 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000005258 227.0
TLS2_k127_1658938_9 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000000000000000000000000000001037 158.0
TLS2_k127_1688946_0 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 2.067e-280 874.0
TLS2_k127_1688946_1 ABC-type transport system involved in Fe-S cluster assembly, ATPase component K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 405.0
TLS2_k127_1688946_2 ABC-type transport system involved in Fe-S cluster assembly, permease component K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002293 276.0
TLS2_k127_1688946_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000777 194.0
TLS2_k127_1688946_4 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.00000000000000000000000000000001447 132.0
TLS2_k127_1692902_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1140.0
TLS2_k127_1692902_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 8.826e-259 805.0
TLS2_k127_1692902_10 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 319.0
TLS2_k127_1692902_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000309 271.0
TLS2_k127_1692902_12 cytochrome C K08738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009521 247.0
TLS2_k127_1692902_13 PFAM Extensin family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007544 248.0
TLS2_k127_1692902_14 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000208 246.0
TLS2_k127_1692902_15 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.00000000000000000000000000000000000000000000000000000000000000000007762 237.0
TLS2_k127_1692902_16 protein conserved in bacteria K09986 - - 0.0000000000000000000000000000000000000000000000000000000000000000009241 231.0
TLS2_k127_1692902_17 Uncharacterized conserved protein (DUF2267) - - - 0.00000000000000000000000000000000000000000000000000000000009831 211.0
TLS2_k127_1692902_18 Domain of unknown function (DUF4349) - - - 0.0000000000000000000000000000000000000000000000000000001559 205.0
TLS2_k127_1692902_19 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.0000000000000000000000000000000000000000000000000001003 191.0
TLS2_k127_1692902_2 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 6.487e-197 620.0
TLS2_k127_1692902_20 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000001958 188.0
TLS2_k127_1692902_21 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000000001598 193.0
TLS2_k127_1692902_22 PRC-barrel domain - - - 0.000000000000000000000000000002334 126.0
TLS2_k127_1692902_23 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000008945 107.0
TLS2_k127_1692902_24 PFAM blue (type 1) copper domain protein - - - 0.0000000000000004262 83.0
TLS2_k127_1692902_25 CHRD domain - - - 0.000000000000135 72.0
TLS2_k127_1692902_3 GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 618.0
TLS2_k127_1692902_4 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000927 482.0
TLS2_k127_1692902_5 Polynucleotide adenylyltransferase K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 464.0
TLS2_k127_1692902_6 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 439.0
TLS2_k127_1692902_7 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 391.0
TLS2_k127_1692902_8 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005846 329.0
TLS2_k127_1692902_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 329.0
TLS2_k127_1752340_0 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 421.0
TLS2_k127_1752340_1 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 386.0
TLS2_k127_1752340_2 enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000005356 270.0
TLS2_k127_1752340_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000000000005393 176.0
TLS2_k127_1752340_4 Phosphate starvation-inducible protein PhoH K06217 - - 0.00000000000000000000000000000000000000000000002028 171.0
TLS2_k127_1752340_5 - - - - 0.00000000001455 72.0
TLS2_k127_175267_0 Protein of unknown function (DUF1343) - - - 1.42e-219 685.0
TLS2_k127_175267_1 Von Willebrand factor A K09989 - - 7.391e-194 619.0
TLS2_k127_175267_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 604.0
TLS2_k127_175267_3 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 594.0
TLS2_k127_175267_4 ATPase AAA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 533.0
TLS2_k127_175267_5 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 515.0
TLS2_k127_175267_6 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000067 323.0
TLS2_k127_175267_7 - - - - 0.00000000000000000000000000000000000007005 148.0
TLS2_k127_175267_8 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.0000000000000000003423 92.0
TLS2_k127_175267_9 endonuclease - - - 0.0000005113 51.0
TLS2_k127_1755068_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 6.166e-240 747.0
TLS2_k127_1755068_1 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 467.0
TLS2_k127_1755068_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 466.0
TLS2_k127_1755068_3 molecular chaperone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009614 424.0
TLS2_k127_1755068_4 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 377.0
TLS2_k127_1755068_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 325.0
TLS2_k127_1755068_6 Acetyltransferase K03824 - - 0.0000000000000000000000000000000002291 138.0
TLS2_k127_1755068_7 Glycine zipper 2TM domain - - - 0.00000000000000000000000000002589 120.0
TLS2_k127_1755068_8 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000000000005344 116.0
TLS2_k127_1774229_0 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 571.0
TLS2_k127_1774229_1 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 369.0
TLS2_k127_1774229_2 TadE-like protein - - - 0.0000000000000000000000000000002026 131.0
TLS2_k127_1774229_3 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.000000000000000000000003594 108.0
TLS2_k127_1774229_4 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000006146 85.0
TLS2_k127_1774229_5 TadE-like protein - - - 0.000000000000001132 86.0
TLS2_k127_181875_0 peptidase S9 K01354 - 3.4.21.83 0.0 1032.0
TLS2_k127_181875_1 aminopeptidase K01262 - 3.4.11.9 3.459e-293 909.0
TLS2_k127_181875_10 - - - - 0.00000000000000000000000000000000000000009053 153.0
TLS2_k127_181875_11 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.000000000000000000000000000419 115.0
TLS2_k127_181875_13 - - - - 0.000000001119 70.0
TLS2_k127_181875_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.672e-206 648.0
TLS2_k127_181875_3 Acyl-CoA dehydrogenase, middle domain - - - 2.201e-202 634.0
TLS2_k127_181875_4 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009162 610.0
TLS2_k127_181875_5 acyl-CoA dehydrogenase K06446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007424 588.0
TLS2_k127_181875_6 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 507.0
TLS2_k127_181875_7 alcohol dehydrogenase K07119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 466.0
TLS2_k127_181875_8 Cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 443.0
TLS2_k127_181875_9 thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000000000001193 208.0
TLS2_k127_1876495_0 Belongs to the ClpA ClpB family K03694 - - 0.0 1103.0
TLS2_k127_1876495_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 560.0
TLS2_k127_1876495_10 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000005569 121.0
TLS2_k127_1876495_11 - - - - 0.00000000009722 66.0
TLS2_k127_1876495_12 DeAcetylase K22278 - 3.5.1.104 0.000729 44.0
TLS2_k127_1876495_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 353.0
TLS2_k127_1876495_3 dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 350.0
TLS2_k127_1876495_4 Belongs to the BI1 family K06890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 308.0
TLS2_k127_1876495_5 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004148 290.0
TLS2_k127_1876495_6 Fructosamine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002748 277.0
TLS2_k127_1876495_7 low molecular weight phosphotyrosine protein phosphatase K01104 - 3.1.3.48 0.0000000000000000000000000000000000000000000000000000000000000000003337 234.0
TLS2_k127_1876495_8 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000000000000000000000000000000000000000000003413 229.0
TLS2_k127_1876495_9 Protein of unknown function (DUF1648) - - - 0.0000000000000000000000000000000000000001932 163.0
TLS2_k127_1939613_0 Acyl-carrier-protein s-malonyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 425.0
TLS2_k127_1939613_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 287.0
TLS2_k127_1939613_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000005667 263.0
TLS2_k127_1957284_0 Endonuclease Exonuclease phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001908 280.0
TLS2_k127_1957284_1 Phage shock protein A K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004742 261.0
TLS2_k127_1957284_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000005513 229.0
TLS2_k127_1957284_3 membrane-associated protein - - - 0.000000000000000000000000000000000000000000001519 169.0
TLS2_k127_1957284_4 - - - - 0.00000000000000000000005338 105.0
TLS2_k127_1957284_5 phage shock protein C K03973 - - 0.0000000000000000000717 97.0
TLS2_k127_1957284_6 - - - - 0.000000000000005388 78.0
TLS2_k127_1957284_7 Transcriptional regulatory protein, C terminal - - - 0.00000000000002664 83.0
TLS2_k127_1957284_8 - - - - 0.0000001287 57.0
TLS2_k127_196126_0 Isocitrate lyase K01637 - 4.1.3.1 1.916e-240 749.0
TLS2_k127_196126_1 Transcriptional regulator K07110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 398.0
TLS2_k127_1987119_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 2.294e-199 636.0
TLS2_k127_1987119_1 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 526.0
TLS2_k127_1987119_2 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 515.0
TLS2_k127_1987119_3 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000009956 209.0
TLS2_k127_1987119_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000004202 191.0
TLS2_k127_1987119_5 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000001136 191.0
TLS2_k127_200454_0 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain K12541 - - 7.28e-257 802.0
TLS2_k127_200454_1 type I secretion membrane fusion protein K12542 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005495 385.0
TLS2_k127_200454_2 Outer membrane efflux protein K12543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 385.0
TLS2_k127_200454_3 COG1320 Multisubunit Na H antiporter, MnhG subunit K05564 - - 0.0000000000000000000000001178 108.0
TLS2_k127_2023790_0 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005774 351.0
TLS2_k127_2023790_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 335.0
TLS2_k127_2023790_2 - - - - 0.00000000000000000000000000003509 123.0
TLS2_k127_2051124_0 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 3.881e-258 815.0
TLS2_k127_2051124_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 534.0
TLS2_k127_2051124_2 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006082 409.0
TLS2_k127_2051124_3 glutamate dehydrogenase K15371 - 1.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 330.0
TLS2_k127_2051124_4 ETC complex I subunit - - - 0.0000000000000000000000000000000119 129.0
TLS2_k127_2051124_5 Nudix hydrolase K01515 - 3.6.1.13 0.0000000000000000000000000000000142 128.0
TLS2_k127_2051124_6 protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - 0.00000000000000000000000002736 109.0
TLS2_k127_2052738_0 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 2.88e-262 824.0
TLS2_k127_2052738_1 COG1253 Hemolysins and related proteins containing CBS domains K03699 - - 8.48e-203 639.0
TLS2_k127_2052738_2 Aerobic cobaltochelatase subunit CobS K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007546 564.0
TLS2_k127_2052738_3 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 293.0
TLS2_k127_2052738_4 lactoylglutathione lyase activity K08234 - - 0.00000000000000000000000000000000000000000000000000000000001712 213.0
TLS2_k127_2052738_5 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000000000000000002626 210.0
TLS2_k127_2052738_6 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000000000000000000000115 166.0
TLS2_k127_2052738_7 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000000000000000000005209 152.0
TLS2_k127_2052738_8 NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - 0.000000000000000000000000000002429 126.0
TLS2_k127_2052738_9 FAD binding domain K22270 - 1.14.13.24 0.000000000000000000005211 95.0
TLS2_k127_2053760_0 de-polymerase K05973 - 3.1.1.75 7.712e-211 660.0
TLS2_k127_2053760_1 ABC-type multidrug transport system, ATPase and permease K06147 - - 0.0000000000000000000000000000000000000000000172 166.0
TLS2_k127_2085014_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 3.057e-270 839.0
TLS2_k127_2085014_1 peptidase U62, modulator of DNA gyrase K03568 - - 4.716e-267 832.0
TLS2_k127_2085014_2 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 482.0
TLS2_k127_2085014_3 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000001569 197.0
TLS2_k127_2085014_4 protein conserved in bacteria - - - 0.00000000000000000000009891 98.0
TLS2_k127_2140530_0 acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 546.0
TLS2_k127_2140530_1 - - - - 0.0000000000000000000000000000000000000000000000007628 181.0
TLS2_k127_2140530_2 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.000000000000000000000000000003482 128.0
TLS2_k127_2147181_0 Asparagine synthase K01953 - 6.3.5.4 2.823e-264 826.0
TLS2_k127_2147181_1 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 616.0
TLS2_k127_2147181_2 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 486.0
TLS2_k127_2147181_3 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 402.0
TLS2_k127_2147181_4 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 372.0
TLS2_k127_2147181_5 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 350.0
TLS2_k127_2147181_6 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 362.0
TLS2_k127_2147181_7 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000436 265.0
TLS2_k127_2205183_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003658 485.0
TLS2_k127_2205183_1 peptidase M48, Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002433 470.0
TLS2_k127_2205183_2 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005126 411.0
TLS2_k127_2205183_3 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000009066 190.0
TLS2_k127_2205183_4 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000003149 174.0
TLS2_k127_2205183_5 Flp pilus assembly protein, pilin Flp K02651 - - 0.00000000000005675 74.0
TLS2_k127_2205183_6 Flp/Fap pilin component K02651 - - 0.0000001395 55.0
TLS2_k127_2241402_0 Choline dehydrogenase K00108 - 1.1.99.1 1.05e-258 813.0
TLS2_k127_2241402_1 Flavin-binding monooxygenase-like - - - 1.338e-229 720.0
TLS2_k127_2241402_2 Belongs to the aldehyde dehydrogenase family K00154 - 1.2.1.68 2.287e-195 622.0
TLS2_k127_2241402_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 337.0
TLS2_k127_2241402_4 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 299.0
TLS2_k127_2241402_5 cytochrome P450 - - - 0.000000000004851 66.0
TLS2_k127_2263436_0 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 291.0
TLS2_k127_2263436_1 WHG domain - - - 0.00000000000000000000000000000000000000000000000000001676 201.0
TLS2_k127_2263436_2 Domain of unknown function (DUF4281) - - - 0.000000000000000000000000000000000001727 143.0
TLS2_k127_2263436_3 - - - - 0.000000000000000000006963 103.0
TLS2_k127_2274178_0 synthase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 333.0
TLS2_k127_2274178_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 301.0
TLS2_k127_2274178_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000008111 53.0
TLS2_k127_2278867_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004371 597.0
TLS2_k127_2278867_1 OmpA family K03286 - - 0.00000001132 65.0
TLS2_k127_228125_0 May be involved in recombinational repair of damaged DNA K03631 - - 1.358e-211 670.0
TLS2_k127_228125_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 7.362e-198 629.0
TLS2_k127_228125_10 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000000008838 105.0
TLS2_k127_228125_11 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.00000000006293 64.0
TLS2_k127_228125_2 D-amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 511.0
TLS2_k127_228125_3 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 444.0
TLS2_k127_228125_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 392.0
TLS2_k127_228125_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 375.0
TLS2_k127_228125_6 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 301.0
TLS2_k127_228125_7 ADP-ribosylglycohydrolase - - - 0.0000000000000000000000000000000000000000000000000009464 187.0
TLS2_k127_228125_8 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000000000000000000000003878 140.0
TLS2_k127_228125_9 Preprotein translocase subunit YajC K03210 - - 0.00000000000000000000000000000001255 131.0
TLS2_k127_228154_0 Peptidase, M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 550.0
TLS2_k127_228154_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 471.0
TLS2_k127_228154_2 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 428.0
TLS2_k127_228154_3 - - - - 0.0000000004006 64.0
TLS2_k127_2285452_0 synthetase K01897 - 6.2.1.3 1.53e-216 677.0
TLS2_k127_2285452_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 324.0
TLS2_k127_2285452_2 - - - - 0.0000000000002151 78.0
TLS2_k127_2310140_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 4.817e-254 802.0
TLS2_k127_2310140_1 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000001918 130.0
TLS2_k127_2394665_0 Amidohydrolase family - - - 4.325e-215 680.0
TLS2_k127_2394665_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 413.0
TLS2_k127_2394665_2 of ABC transporters with duplicated ATPase K15738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 377.0
TLS2_k127_2394665_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 344.0
TLS2_k127_2394665_4 M61 glycyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001814 265.0
TLS2_k127_2394665_5 Protein of unknown function (DUF4199) - - - 0.00000000000000000000000000000000000000000001467 169.0
TLS2_k127_2394665_6 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000002849 161.0
TLS2_k127_2394665_7 - - - - 0.0000000000000006063 81.0
TLS2_k127_2399589_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 3.488e-195 622.0
TLS2_k127_2399589_1 Phosphate starvation-inducible protein PhoH K06217 - - 0.0000000000000000000000000000000000000000006246 176.0
TLS2_k127_2399589_2 Acyltransferase K00655 - 2.3.1.51 0.00000000006109 64.0
TLS2_k127_2424687_0 protein conserved in bacteria K09800 - - 0.0 1490.0
TLS2_k127_2424687_1 PFAM Amylo-alpha-16-glucosidase - - - 1.933e-261 824.0
TLS2_k127_2424687_10 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001362 269.0
TLS2_k127_2424687_11 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000008605 210.0
TLS2_k127_2424687_12 EVE domain - - - 0.000000000000000000000000000000000000000000000000000004053 193.0
TLS2_k127_2424687_13 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000001185 204.0
TLS2_k127_2424687_14 oxidase, subunit K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000008113 169.0
TLS2_k127_2424687_15 COG3773 Cell wall hydrolyses involved in spore germination K01449 - 3.5.1.28 0.00000000000000000000000000000000000000000007847 168.0
TLS2_k127_2424687_16 Hpt domain K20976 - - 0.00000000000000000000000000000000000001383 149.0
TLS2_k127_2424687_17 - - - - 0.0000000000000000000000209 106.0
TLS2_k127_2424687_18 antiporter - - - 0.00000000000000001358 83.0
TLS2_k127_2424687_19 - - - - 0.000000000000001183 81.0
TLS2_k127_2424687_2 COG0729 Outer membrane protein K07278 - - 5.241e-227 720.0
TLS2_k127_2424687_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 3.917e-222 697.0
TLS2_k127_2424687_4 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 595.0
TLS2_k127_2424687_5 Pyrrolo-quinoline quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 495.0
TLS2_k127_2424687_6 PFAM glycosyl transferase group 1 K12995 - 2.4.1.348 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 466.0
TLS2_k127_2424687_7 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006569 424.0
TLS2_k127_2424687_8 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 368.0
TLS2_k127_2424687_9 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 329.0
TLS2_k127_2453718_0 aminopeptidase N K01256 - 3.4.11.2 0.0 1237.0
TLS2_k127_2453718_1 Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine K01761 - 4.4.1.11 1.8e-230 743.0
TLS2_k127_2453718_10 HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001624 258.0
TLS2_k127_2453718_11 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.00000000000000000000000000000000000000000000000000000002763 203.0
TLS2_k127_2453718_12 transport system auxiliary component K18480 - - 0.00000000000000000000000000000000000000000006932 166.0
TLS2_k127_2453718_13 MgtC family - - - 0.0000000000000000000000000000000000000005572 153.0
TLS2_k127_2453718_15 Sigma-70, region 4 K03088 - - 0.00000000000000000000004414 105.0
TLS2_k127_2453718_16 Putative zinc-finger - - - 0.0008576 48.0
TLS2_k127_2453718_2 Sodium:sulfate symporter transmembrane region K14445 - - 2.464e-206 652.0
TLS2_k127_2453718_3 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009208 480.0
TLS2_k127_2453718_4 Threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 467.0
TLS2_k127_2453718_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 478.0
TLS2_k127_2453718_6 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 403.0
TLS2_k127_2453718_7 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 383.0
TLS2_k127_2453718_8 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 374.0
TLS2_k127_2453718_9 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009766 310.0
TLS2_k127_2461261_0 4Fe-4S dicluster domain - - - 0.0 1176.0
TLS2_k127_2461261_1 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 299.0
TLS2_k127_2461261_2 cytochrome c biogenesis K02200 - - 0.00000000000000000000000000000000000000000000000000000000000000001637 235.0
TLS2_k127_2461261_3 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000005982 102.0
TLS2_k127_2549021_0 Heat shock 70 kDa protein K04043 - - 6.427e-206 645.0
TLS2_k127_2549021_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 446.0
TLS2_k127_2549021_2 Bacterial PH domain - - - 0.0000000000000000000000000000000000000000000000000008736 193.0
TLS2_k127_2549021_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000001633 166.0
TLS2_k127_2549021_4 Copper chaperone PCu(A)C K09796 - - 0.00000000000000000000000007154 113.0
TLS2_k127_255112_0 2-methylthioadenine K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 510.0
TLS2_k127_255112_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 349.0
TLS2_k127_255112_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001556 276.0
TLS2_k127_255112_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000001557 57.0
TLS2_k127_2579598_0 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 4.358e-227 709.0
TLS2_k127_2579598_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 591.0
TLS2_k127_2579598_10 acetyltransferase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000009282 167.0
TLS2_k127_2579598_11 RDD family - - - 0.000000000000000000000000007658 112.0
TLS2_k127_2579598_2 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000556 546.0
TLS2_k127_2579598_3 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 510.0
TLS2_k127_2579598_4 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 505.0
TLS2_k127_2579598_5 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 474.0
TLS2_k127_2579598_6 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 468.0
TLS2_k127_2579598_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 342.0
TLS2_k127_2579598_8 2-hydroxychromene-2-carboxylate isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 338.0
TLS2_k127_2579598_9 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 327.0
TLS2_k127_2591034_0 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 6.376e-201 629.0
TLS2_k127_2591034_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 310.0
TLS2_k127_2594390_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 580.0
TLS2_k127_2594390_1 in Escherichia coli this protein forms a dimer and binds manganese K11532 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 532.0
TLS2_k127_2594390_2 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000000000000000000000000000000000000004855 207.0
TLS2_k127_269059_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 1.468e-271 856.0
TLS2_k127_269059_1 leukotriene A-4 hydrolase - - - 1.045e-228 739.0
TLS2_k127_269059_2 DoxX-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 470.0
TLS2_k127_269059_3 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 398.0
TLS2_k127_269059_4 lysozyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 385.0
TLS2_k127_269059_5 PhzC PhzF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009776 350.0
TLS2_k127_269059_6 Predicted integral membrane protein (DUF2269) - - - 0.00000000000000000000000000000000000000000000000000000000001741 228.0
TLS2_k127_269059_7 - - - - 0.000000000000000000000000000000000006039 150.0
TLS2_k127_269059_8 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.0000000000009374 68.0
TLS2_k127_274726_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000008184 234.0
TLS2_k127_274726_1 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000002828 184.0
TLS2_k127_274726_2 Fatty acid hydroxylase superfamily - - - 0.00000000000000000005697 91.0
TLS2_k127_274726_3 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000021 76.0
TLS2_k127_2781898_0 AAA ATPase domain - - - 5.993e-218 711.0
TLS2_k127_2781898_1 PPIC-type PPIASE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 439.0
TLS2_k127_2781898_2 peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 447.0
TLS2_k127_2781898_3 Nitrate reductase gamma subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 395.0
TLS2_k127_2781898_4 Patatin-like phospholipase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003683 334.0
TLS2_k127_2781898_5 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000262 181.0
TLS2_k127_27851_0 MacB-like periplasmic core domain K02004 - - 1.526e-303 952.0
TLS2_k127_27851_1 MacB-like periplasmic core domain K02004 - - 5.333e-267 845.0
TLS2_k127_27851_2 MacB-like periplasmic core domain K02004 - - 1.037e-210 714.0
TLS2_k127_27851_4 - - - - 0.00000000002866 74.0
TLS2_k127_2815945_0 5-methyltetrahydrofolate--homocysteine methyltransferase K00548 - 2.1.1.13 0.0 1272.0
TLS2_k127_2815945_1 Thiol disulfide interchange protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002781 290.0
TLS2_k127_2909242_0 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009798 561.0
TLS2_k127_2909242_1 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004177 547.0
TLS2_k127_2909242_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004056 274.0
TLS2_k127_2911351_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 444.0
TLS2_k127_2911351_1 transporter component K07112 - - 0.0000000000000000000000000000000000000000000005641 170.0
TLS2_k127_2911351_2 Sulphur transport K07112 - - 0.0000000000000000000000000000000000003485 144.0
TLS2_k127_2911351_3 Putative phosphatase (DUF442) - - - 0.0000000000000000000000000001804 121.0
TLS2_k127_2911351_4 Sulfate permease family K03321 - - 0.0000000000000000000000475 105.0
TLS2_k127_2911812_0 membrane K08988 - - 0.000000000000000000000000000000000000000000000000000000000000001557 233.0
TLS2_k127_2911812_1 Methanol dehydrogenase K06872 - - 0.000000000000000000000000000000000000000000000000000000002176 205.0
TLS2_k127_2911812_2 Nudix hydrolase K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000009988 169.0
TLS2_k127_2971172_0 MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 497.0
TLS2_k127_2971172_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009958 417.0
TLS2_k127_2971172_2 Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 385.0
TLS2_k127_2971172_3 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006615 316.0
TLS2_k127_2971172_4 YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 285.0
TLS2_k127_2971172_5 MobA-like NTP transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002427 235.0
TLS2_k127_2971172_6 lactoylglutathione lyase activity K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000002391 167.0
TLS2_k127_2973570_0 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 346.0
TLS2_k127_2973570_1 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 299.0
TLS2_k127_2973570_2 Protein of unknown function (DUF3618) - - - 0.0000000000000000000000000000000000000005208 164.0
TLS2_k127_2973570_3 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000005049 54.0
TLS2_k127_2979464_0 DNA helicase K03654 - 3.6.4.12 2.752e-265 826.0
TLS2_k127_2979464_1 iron ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 295.0
TLS2_k127_2979464_2 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000004732 238.0
TLS2_k127_3007990_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 531.0
TLS2_k127_3007990_1 Outer membrane usher protein K07347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 505.0
TLS2_k127_3007990_10 Spore Coat Protein U domain - - - 0.00000000000000000000003156 105.0
TLS2_k127_3007990_11 Belongs to the peptidase M48B family K03799 - - 0.0000000000005705 70.0
TLS2_k127_3007990_12 Protein of unknown function (DUF1674) - - - 0.0000000001129 65.0
TLS2_k127_3007990_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 433.0
TLS2_k127_3007990_3 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006629 441.0
TLS2_k127_3007990_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 388.0
TLS2_k127_3007990_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 316.0
TLS2_k127_3007990_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000824 245.0
TLS2_k127_3007990_7 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000005547 218.0
TLS2_k127_3007990_8 Spore Coat Protein U domain - - - 0.00000000000000000000000000000000004567 141.0
TLS2_k127_3007990_9 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.0000000000000000000000000000002845 132.0
TLS2_k127_3034038_0 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 443.0
TLS2_k127_3034038_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000337 258.0
TLS2_k127_3034038_2 Peptidase, M16 - - - 0.00000000000000000000000000000000000000000611 156.0
TLS2_k127_3034038_3 GGDEF domain - - - 0.00000000254 68.0
TLS2_k127_3034688_0 Peptidase family M3 K01284 - 3.4.15.5 2.318e-310 968.0
TLS2_k127_3034688_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 1.106e-243 770.0
TLS2_k127_3034688_10 2-methylthioadenine K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000002094 207.0
TLS2_k127_3034688_11 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000003097 173.0
TLS2_k127_3034688_12 - - - - 0.000000000000000000000000000000000000000000003867 173.0
TLS2_k127_3034688_13 lyase activity - - - 0.0000000000000000000000000000000000000006404 161.0
TLS2_k127_3034688_14 - - - - 0.00000000000000000000000000000000000008672 157.0
TLS2_k127_3034688_15 Tetratricopeptide repeat - - - 0.000000000000000000000000000000001022 138.0
TLS2_k127_3034688_16 PFAM NHL repeat containing protein - - - 0.0000000000000007059 88.0
TLS2_k127_3034688_17 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000002014 80.0
TLS2_k127_3034688_2 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 512.0
TLS2_k127_3034688_3 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 482.0
TLS2_k127_3034688_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 463.0
TLS2_k127_3034688_5 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 428.0
TLS2_k127_3034688_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 329.0
TLS2_k127_3034688_7 pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 294.0
TLS2_k127_3034688_8 probably involved in intracellular septation K06190 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004898 270.0
TLS2_k127_3034688_9 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001286 266.0
TLS2_k127_3041288_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.162e-251 779.0
TLS2_k127_3041288_1 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000207 271.0
TLS2_k127_3041288_2 - - - - 0.0000000000000000000000000000000000001295 145.0
TLS2_k127_3041288_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000004199 79.0
TLS2_k127_3041529_0 GTP-binding protein TypA K06207 - - 0.0 1050.0
TLS2_k127_3041529_1 Protein of unknown function (DUF805) - - - 0.0000000000000000000000000000000001035 140.0
TLS2_k127_3041529_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000003493 118.0
TLS2_k127_3041529_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000001028 98.0
TLS2_k127_3041529_5 - - - - 0.000000000000003698 77.0
TLS2_k127_3041529_6 response regulator K13589 - - 0.0000000002981 64.0
TLS2_k127_3108408_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 8.209e-261 820.0
TLS2_k127_3108408_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 472.0
TLS2_k127_3108408_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 364.0
TLS2_k127_3108408_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 307.0
TLS2_k127_3108408_4 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001637 276.0
TLS2_k127_3108408_5 Lycopene cyclase protein K06443 - 5.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000006069 233.0
TLS2_k127_3124146_0 NADH ubiquinone oxidoreductase subunit 5 (Chain L) multisubunit Na H antiporter, MnhA subunit K05559 - - 0.0 1255.0
TLS2_k127_3124146_1 ATP-dependent DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.496e-267 832.0
TLS2_k127_3124146_10 Multisubunit Na H antiporter, MnhC subunit K05560 - - 0.00000000000000000000000000000000000000000000000009673 182.0
TLS2_k127_3124146_11 Proton-conducting membrane transporter K05561 - - 0.0000000000000000000000000000000000000002756 160.0
TLS2_k127_3124146_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 4.983e-200 634.0
TLS2_k127_3124146_3 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 411.0
TLS2_k127_3124146_4 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007455 386.0
TLS2_k127_3124146_5 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 342.0
TLS2_k127_3124146_6 Cold shock K03704 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 345.0
TLS2_k127_3124146_7 PFAM Pentapeptide repeats (8 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000002249 249.0
TLS2_k127_3124146_8 Protein conserved in bacteria K11719 - - 0.00000000000000000000000000000000000000000000000000000000006676 216.0
TLS2_k127_3124146_9 protein conserved in bacteria K09774 - - 0.000000000000000000000000000000000000000000000000000004513 202.0
TLS2_k127_3153835_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1781.0
TLS2_k127_3153835_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0 1094.0
TLS2_k127_3153835_10 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007826 492.0
TLS2_k127_3153835_11 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 468.0
TLS2_k127_3153835_12 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 433.0
TLS2_k127_3153835_13 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 427.0
TLS2_k127_3153835_14 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005949 421.0
TLS2_k127_3153835_15 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 424.0
TLS2_k127_3153835_16 peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 417.0
TLS2_k127_3153835_17 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004688 395.0
TLS2_k127_3153835_18 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 354.0
TLS2_k127_3153835_19 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007537 271.0
TLS2_k127_3153835_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 5e-324 999.0
TLS2_k127_3153835_20 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000175 267.0
TLS2_k127_3153835_21 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000000000000000000004457 250.0
TLS2_k127_3153835_22 ATPase involved in DNA replication - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001667 251.0
TLS2_k127_3153835_23 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000000000003717 256.0
TLS2_k127_3153835_24 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000004331 239.0
TLS2_k127_3153835_25 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000000000000000000000000000000000005618 232.0
TLS2_k127_3153835_26 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000000000000000000000000000000000001523 190.0
TLS2_k127_3153835_27 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000003389 151.0
TLS2_k127_3153835_28 - - - - 0.000000000000000000000000000000001074 139.0
TLS2_k127_3153835_29 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000000000000000000000001368 129.0
TLS2_k127_3153835_3 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 3e-323 1005.0
TLS2_k127_3153835_30 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000003636 115.0
TLS2_k127_3153835_31 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000005859 103.0
TLS2_k127_3153835_4 Histidine kinase K13587 - 2.7.13.3 4.51e-275 878.0
TLS2_k127_3153835_5 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088,K00364 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205,1.7.1.7 2.677e-203 644.0
TLS2_k127_3153835_6 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 613.0
TLS2_k127_3153835_7 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 606.0
TLS2_k127_3153835_8 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 576.0
TLS2_k127_3153835_9 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 591.0
TLS2_k127_316522_0 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 402.0
TLS2_k127_316522_1 Protein of unknown function (DUF1326) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 373.0
TLS2_k127_316522_2 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0000000000000000000000000000000000000000000000002212 190.0
TLS2_k127_316522_3 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.000000000000000000000000000000000001292 143.0
TLS2_k127_316522_4 Lycopene cyclase protein K06443 - 5.5.1.19 0.000158 44.0
TLS2_k127_3224857_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1282.0
TLS2_k127_3224857_1 Protein of unknown function (DUF3376) - - - 6.007e-285 895.0
TLS2_k127_3224857_2 COG1680 Beta-lactamase class C and other penicillin binding proteins K01467 - 3.5.2.6 0.000000000000000000000000000000000000000000003975 170.0
TLS2_k127_3224857_3 Usg-like family - - - 0.0000000000000000000000000000000000000006323 150.0
TLS2_k127_3224857_4 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000000000169 149.0
TLS2_k127_3224857_5 - - - - 0.00000000000000000007564 96.0
TLS2_k127_3238236_0 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 0.0 1091.0
TLS2_k127_3238236_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 1.144e-200 629.0
TLS2_k127_3238236_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 299.0
TLS2_k127_3238236_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002035 274.0
TLS2_k127_3238236_4 - - - - 0.00000000000000000000000000008331 121.0
TLS2_k127_3238236_5 - - - - 0.0005764 50.0
TLS2_k127_3246957_0 Predicted membrane protein (DUF2339) - - - 8.505e-253 802.0
TLS2_k127_3246957_1 Small Multidrug Resistance protein K11741 - - 0.00004754 45.0
TLS2_k127_327006_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 402.0
TLS2_k127_327006_1 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001109 281.0
TLS2_k127_327006_2 PhzC PhzF - - - 0.000000000000000000000000000000000000000000000000768 180.0
TLS2_k127_3281354_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1362.0
TLS2_k127_3281354_1 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0 1210.0
TLS2_k127_3281354_10 - - - - 0.00000000000000000000000000000000000000005527 164.0
TLS2_k127_3281354_11 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.00000000000000008255 80.0
TLS2_k127_3281354_12 Belongs to the UPF0337 (CsbD) family - - - 0.000000001292 61.0
TLS2_k127_3281354_14 - - - - 0.00002599 49.0
TLS2_k127_3281354_2 helicase K16899 - 3.6.4.12 0.0 1196.0
TLS2_k127_3281354_3 Histidine kinase - - - 9.273e-253 794.0
TLS2_k127_3281354_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001494 274.0
TLS2_k127_3281354_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000001619 218.0
TLS2_k127_3281354_6 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000009704 193.0
TLS2_k127_3281354_7 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000001205 186.0
TLS2_k127_3281354_8 - - - - 0.000000000000000000000000000000000000000000000006377 181.0
TLS2_k127_3281354_9 PilZ domain - - - 0.0000000000000000000000000000000000000000000009898 180.0
TLS2_k127_3334175_0 protein conserved in bacteria K09987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 325.0
TLS2_k127_3334175_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000001118 235.0
TLS2_k127_3338554_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 618.0
TLS2_k127_3338554_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 414.0
TLS2_k127_3338554_2 Thioredoxin reductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 399.0
TLS2_k127_3338554_3 transcriptional - - - 0.00000000000000000000000000000000000000000000000000000000000001023 222.0
TLS2_k127_3338554_4 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000000000000001593 214.0
TLS2_k127_3338554_5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.00000000000000000000000000000000000000000000000000001767 194.0
TLS2_k127_3338554_6 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.00000000000000000001846 100.0
TLS2_k127_3494228_0 metal-binding protein - - - 0.0000000000000000000000000000000000000000000003137 171.0
TLS2_k127_3494228_1 PepSY-associated TM region - - - 0.000000000000000000000000000000000000000005939 164.0
TLS2_k127_3494228_2 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000000000000000000000747 134.0
TLS2_k127_3518953_0 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 583.0
TLS2_k127_3518953_1 Domain of unknown function (DUF4893) - - - 0.0000000000000000000000000000000000000000000000000000006713 203.0
TLS2_k127_3518953_2 - - - - 0.000000006149 61.0
TLS2_k127_3518953_3 Belongs to the peptidase S1B family - - - 0.0000003937 58.0
TLS2_k127_3521525_0 phosphomannomutase K01840 - 5.4.2.8 4.16e-227 710.0
TLS2_k127_3521525_1 involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 368.0
TLS2_k127_3521525_2 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000002144 102.0
TLS2_k127_3521525_3 DnaJ molecular chaperone homology domain - - - 0.000000000000000006258 87.0
TLS2_k127_3529426_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 580.0
TLS2_k127_3529426_1 Inositol-3-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009196 542.0
TLS2_k127_3529426_2 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000001443 255.0
TLS2_k127_3529426_3 CDP-alcohol phosphatidyltransferase K07281,K07291 - 2.7.7.74,2.7.8.34 0.0000000000000000000000000000000000000000000000000002465 199.0
TLS2_k127_3529426_4 lipopolysaccharide-transporting ATPase activity K07091,K11720 - - 0.000000000000000000000000000000000000002647 168.0
TLS2_k127_3529426_5 Permease, YjgP YjgQ family K11720 - - 0.000000000000000000000002009 120.0
TLS2_k127_3591728_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 405.0
TLS2_k127_3591728_1 Molybdopterin K03635 - 2.8.1.12 0.00000000000000000000000000000000000001992 150.0
TLS2_k127_3591728_2 protein conserved in bacteria K09790 - - 0.00000000000000000000000000000001196 130.0
TLS2_k127_3591728_3 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.0000001451 58.0
TLS2_k127_3595255_0 TrkA-N domain - - - 9.622e-220 696.0
TLS2_k127_3595255_1 Folylpolyglutamate synthase K01930 - 6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 396.0
TLS2_k127_3595255_2 transcriptional regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 368.0
TLS2_k127_3595255_3 Aminomethyltransferase K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 329.0
TLS2_k127_3595255_4 Belongs to the UPF0335 family - - - 0.000000000000000000000000000003235 121.0
TLS2_k127_3597960_0 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000001987 203.0
TLS2_k127_3597960_1 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000001073 147.0
TLS2_k127_3597960_2 - - - - 0.0000000000000001046 83.0
TLS2_k127_3597960_3 UPF0314 protein - - - 0.0000000007082 61.0
TLS2_k127_363092_0 signal peptide peptidase K04773 - - 1.261e-222 707.0
TLS2_k127_363092_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 500.0
TLS2_k127_363092_2 Bacterial transcriptional repressor C-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001525 281.0
TLS2_k127_363092_3 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000008736 197.0
TLS2_k127_363092_4 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000000002539 179.0
TLS2_k127_363092_5 Protein of unknown function (DUF1761) - - - 0.0000000000000000000000000000000000000215 156.0
TLS2_k127_363092_6 Domain of unknown function (DUF202) K00389 - - 0.00000000000000000000000000000001284 140.0
TLS2_k127_363092_7 glyoxalase III activity - - - 0.00000000000000000000000000002463 131.0
TLS2_k127_363092_8 - - - - 0.00000000000000000000005745 111.0
TLS2_k127_363092_9 chemotaxis K03406 - - 0.00000000000001466 81.0
TLS2_k127_3684277_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.194e-216 675.0
TLS2_k127_3684277_1 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 474.0
TLS2_k127_3684277_2 enoyl-CoA hydratase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 449.0
TLS2_k127_3684277_3 poly(R)-hydroxyalkanoic acid synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001992 392.0
TLS2_k127_3727911_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 3.283e-254 790.0
TLS2_k127_3727911_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.58e-229 717.0
TLS2_k127_3727911_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 352.0
TLS2_k127_3727911_3 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007405 340.0
TLS2_k127_3727911_4 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 319.0
TLS2_k127_3727911_5 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000000000000000000001152 235.0
TLS2_k127_3727911_6 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000002042 181.0
TLS2_k127_3748083_0 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004803 391.0
TLS2_k127_3748083_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 391.0
TLS2_k127_3748083_2 - - - - 0.0000000000000009373 89.0
TLS2_k127_3748382_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 542.0
TLS2_k127_3748382_1 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 396.0
TLS2_k127_3748382_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000002466 84.0
TLS2_k127_3748382_3 - - - - 0.00000000000034 73.0
TLS2_k127_3772599_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1378.0
TLS2_k127_3772599_1 peptidase S9 - - - 9.568e-280 876.0
TLS2_k127_3772599_2 membrane K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 535.0
TLS2_k127_3772599_3 protein-L-isoaspartate K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000001281 236.0
TLS2_k127_3772599_4 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000004308 177.0
TLS2_k127_3772599_5 Protein of unknown function (DUF2497) K09991 - - 0.000000000000000000000001029 108.0
TLS2_k127_3799512_0 2-nitropropane dioxygenase - - - 3.587e-269 833.0
TLS2_k127_3799512_1 Glycosyl transferase family 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 418.0
TLS2_k127_3799512_2 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000003858 190.0
TLS2_k127_3799512_3 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000001358 189.0
TLS2_k127_3799512_4 PFAM Bacterial regulatory proteins, crp family, Cyclic nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000001409 177.0
TLS2_k127_3799512_6 Phage Tail Collar Domain - - - 0.000000000006338 65.0
TLS2_k127_3844269_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 1.924e-214 685.0
TLS2_k127_3844269_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003541 511.0
TLS2_k127_3844269_2 - - - - 0.0000000000000007239 85.0
TLS2_k127_3848731_0 Glucoamylase - - - 7.256e-281 878.0
TLS2_k127_3848731_1 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 1.283e-213 674.0
TLS2_k127_3848731_2 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003814 285.0
TLS2_k127_3848731_3 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000289 239.0
TLS2_k127_3848731_4 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003494 244.0
TLS2_k127_3848731_5 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000006862 219.0
TLS2_k127_3848731_6 Phage Tail Collar Domain - - - 0.000000000000000000000000000000000000000000000000000000000002021 212.0
TLS2_k127_3848731_7 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000005696 183.0
TLS2_k127_3848731_8 Glycine zipper 2TM domain - - - 0.000000000000000000000000000000000000000000962 162.0
TLS2_k127_3867951_0 Belongs to the Orn Lys Arg decarboxylase class-II family K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008937 531.0
TLS2_k127_3867951_1 Chain-length determining protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007372 483.0
TLS2_k127_3867951_2 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 385.0
TLS2_k127_3867951_3 Type II secretory pathway, component ExeA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 368.0
TLS2_k127_3867951_4 polysaccharide export K01991 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002459 291.0
TLS2_k127_3867951_5 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006072 263.0
TLS2_k127_3867951_6 involved in chromosome partitioning - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008465 263.0
TLS2_k127_3867951_7 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000000000000000000000000000000000000000000000000000000000005523 225.0
TLS2_k127_3873315_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1290.0
TLS2_k127_3873315_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 1.915e-212 692.0
TLS2_k127_3873315_10 protein conserved in bacteria K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 330.0
TLS2_k127_3873315_11 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008031 311.0
TLS2_k127_3873315_12 pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 309.0
TLS2_k127_3873315_13 NAD(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004556 289.0
TLS2_k127_3873315_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002275 275.0
TLS2_k127_3873315_15 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K04756 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001292 267.0
TLS2_k127_3873315_16 lyase activity - - - 0.000000000000000000000000000000000000000000004566 177.0
TLS2_k127_3873315_17 Domain of unknown function (DUF4383) - - - 0.0000000000000000000000000000000000008903 149.0
TLS2_k127_3873315_18 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000001982 144.0
TLS2_k127_3873315_19 - - - - 0.00000000000006886 79.0
TLS2_k127_3873315_2 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 1.428e-198 629.0
TLS2_k127_3873315_20 - - - - 0.000000000002665 68.0
TLS2_k127_3873315_21 PilZ domain - - - 0.00002534 52.0
TLS2_k127_3873315_3 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009353 593.0
TLS2_k127_3873315_4 alanine symporter K03310 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 549.0
TLS2_k127_3873315_5 aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009337 503.0
TLS2_k127_3873315_6 Transcriptional regulator K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005437 482.0
TLS2_k127_3873315_7 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 383.0
TLS2_k127_3873315_8 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 375.0
TLS2_k127_3873315_9 Alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003785 327.0
TLS2_k127_3887672_0 protein conserved in bacteria K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006032 569.0
TLS2_k127_3887672_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000868 394.0
TLS2_k127_3887672_2 glycerophosphoryl diester phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009536 262.0
TLS2_k127_3887672_3 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000000003233 132.0
TLS2_k127_3887672_4 endoribonuclease - - - 0.0000000003577 60.0
TLS2_k127_3887672_5 involved in chromosome partitioning K03496 - - 0.000003056 49.0
TLS2_k127_3892918_0 DNA ligase K01971 - 6.5.1.1 0.0 1069.0
TLS2_k127_3892918_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0 1020.0
TLS2_k127_3892918_10 helix_turn_helix ASNC type K05800 - - 0.000000000000000000000000000000000000000000000000001488 186.0
TLS2_k127_3892918_11 - - - - 0.0000000000000000000000000000000000000000000000008416 182.0
TLS2_k127_3892918_12 - - - - 0.0000000000000000000000000000000000000000000004076 175.0
TLS2_k127_3892918_13 RDD family - - - 0.000000000000000000000000000005762 124.0
TLS2_k127_3892918_14 Glycine zipper 2TM domain - - - 0.00000000000000000000000001856 112.0
TLS2_k127_3892918_15 Cytochrome C' - - - 0.000000000000000000000003046 108.0
TLS2_k127_3892918_17 - - - - 0.0000000000000001274 89.0
TLS2_k127_3892918_2 Toxic anion resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 581.0
TLS2_k127_3892918_3 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 482.0
TLS2_k127_3892918_4 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 494.0
TLS2_k127_3892918_5 PFAM Aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 461.0
TLS2_k127_3892918_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 400.0
TLS2_k127_3892918_7 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 397.0
TLS2_k127_3892918_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009217 289.0
TLS2_k127_3892918_9 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000009347 213.0
TLS2_k127_3902106_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 7.392e-232 734.0
TLS2_k127_3902106_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 593.0
TLS2_k127_3902106_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 492.0
TLS2_k127_3902106_3 ergosterol biosynthetic process K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000003349 198.0
TLS2_k127_3902106_4 EF hand - - - 0.000000000000000000000000000000000255 137.0
TLS2_k127_3902106_5 Septum formation initiator - - - 0.00000000000000000000000003343 111.0
TLS2_k127_3906930_0 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 2.254e-278 868.0
TLS2_k127_3906930_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000002497 70.0
TLS2_k127_3908317_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1263.0
TLS2_k127_3908317_1 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 585.0
TLS2_k127_3908317_2 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003516 271.0
TLS2_k127_3908317_3 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000003419 272.0
TLS2_k127_3908317_4 Glycine zipper 2TM domain - - - 0.00000000000000000000000000003661 120.0
TLS2_k127_3908317_5 ErfK ybiS ycfS ynhG family protein K16291 - - 0.000000000686 66.0
TLS2_k127_3908317_6 PspC domain K03973 - - 0.000004502 56.0
TLS2_k127_3908317_7 Protein of unknown function (DUF3617) - - - 0.0003605 50.0
TLS2_k127_3910793_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 1.178e-203 638.0
TLS2_k127_3910793_1 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 597.0
TLS2_k127_3910793_2 Putative 2OG-Fe(II) oxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 317.0
TLS2_k127_3910793_3 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000003205 212.0
TLS2_k127_3917049_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 524.0
TLS2_k127_3917049_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000004826 215.0
TLS2_k127_3917049_2 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000002691 218.0
TLS2_k127_3917857_0 Prolyl oligopeptidase K01322 - 3.4.21.26 5.261e-300 938.0
TLS2_k127_3917857_1 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 - 1.2.1.71 9.315e-232 725.0
TLS2_k127_3917857_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 7.001e-206 647.0
TLS2_k127_3917857_3 Uncharacterized ACR, YdiU/UPF0061 family - - - 2.713e-199 630.0
TLS2_k127_3917857_4 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 412.0
TLS2_k127_3917857_5 PFAM Bacterial regulatory proteins, crp family, Cyclic nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000001586 172.0
TLS2_k127_3917857_6 In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media - - - 0.000003391 56.0
TLS2_k127_3952358_0 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000039 276.0
TLS2_k127_3952358_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000008752 124.0
TLS2_k127_3970915_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 295.0
TLS2_k127_3970915_1 import inner membrane translocase, subunit Tim44 - - - 0.0000000000000000000000000000000000000000000000000000000000000000005588 234.0
TLS2_k127_3970915_2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000000000000000000000000000000000008944 234.0
TLS2_k127_3987640_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005984 549.0
TLS2_k127_3987640_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 546.0
TLS2_k127_3987640_2 4-hydroxyphenylpyruvate dioxygenase K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000774 342.0
TLS2_k127_3987640_3 TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated - - - 0.00000000000000000000000000000000000000000000000002086 194.0
TLS2_k127_3987640_4 acyl carrier protein - - - 0.00000000000000000000000000002146 121.0
TLS2_k127_3987640_5 TIGRFAM hydrolase, ortholog 2, exosortase system type 1 associated - - - 0.00000002467 64.0
TLS2_k127_4020933_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 629.0
TLS2_k127_4020933_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 416.0
TLS2_k127_4020933_10 N-terminal domain of Peptidase_S41 in eukaryotic IRBP - - - 0.0001269 53.0
TLS2_k127_4020933_2 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004882 258.0
TLS2_k127_4020933_3 COG0793 Periplasmic protease - - - 0.0000000000000000000000000000000000000000000000000007496 194.0
TLS2_k127_4020933_4 AsnC-type helix-turn-helix domain - - - 0.000000000000000000000000000001611 138.0
TLS2_k127_4020933_5 PilZ domain - - - 0.000000000000000000000000101 118.0
TLS2_k127_4020933_6 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000002572 87.0
TLS2_k127_4020933_7 MOFRL family K11529 - 2.7.1.165 0.0000000000004063 70.0
TLS2_k127_4020933_8 PilZ domain - - - 0.00000001008 62.0
TLS2_k127_4020933_9 Peptidase family S41 - - - 0.00000001255 62.0
TLS2_k127_4021209_0 Peptidase, M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 616.0
TLS2_k127_4021209_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 462.0
TLS2_k127_4021209_2 Response regulator of the LytR AlgR family K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 332.0
TLS2_k127_4021209_3 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 319.0
TLS2_k127_4021209_4 SOS response K14160 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - 0.0000000000000000000000000000000000000000005835 167.0
TLS2_k127_4110219_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 8.882e-316 971.0
TLS2_k127_4110219_1 Histidine K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 596.0
TLS2_k127_4110219_10 transcriptional regulator - - - 0.0000000000000000000000000000000001398 140.0
TLS2_k127_4110219_11 - - - - 0.00000000000000000000000000000000663 133.0
TLS2_k127_4110219_12 Flavin reductase like domain - - - 0.0000000000000000000000000000001673 129.0
TLS2_k127_4110219_13 Inositol monophosphatase family - - - 0.000005076 51.0
TLS2_k127_4110219_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 515.0
TLS2_k127_4110219_3 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 470.0
TLS2_k127_4110219_4 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 447.0
TLS2_k127_4110219_5 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01479,K01480 - 3.5.3.11,3.5.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 320.0
TLS2_k127_4110219_6 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002613 296.0
TLS2_k127_4110219_7 dioxygenase of extradiol dioxygenase family K06991 - - 0.0000000000000000000000000000000000000000000000000000000000009917 216.0
TLS2_k127_4110219_8 TAP-like protein - - - 0.000000000000000000000000000000000000000000000000000000000001022 231.0
TLS2_k127_4110219_9 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000001436 160.0
TLS2_k127_4135404_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 1.384e-196 620.0
TLS2_k127_4135404_1 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 536.0
TLS2_k127_4135404_2 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000001007 153.0
TLS2_k127_4135809_0 thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006604 291.0
TLS2_k127_4135809_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000001386 243.0
TLS2_k127_4135809_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000000000000000000000000000000000000001253 203.0
TLS2_k127_4161351_0 Peptidase, M28 - - - 1.791e-227 716.0
TLS2_k127_4161351_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 454.0
TLS2_k127_4161351_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007304 376.0
TLS2_k127_4161351_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 318.0
TLS2_k127_4161351_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000003599 208.0
TLS2_k127_4161351_5 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000002485 184.0
TLS2_k127_418460_0 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 4.402e-267 826.0
TLS2_k127_418460_1 acyl-CoA dehydrogenase K20035 - - 5.755e-245 768.0
TLS2_k127_418460_10 Belongs to the GSP D family K02280 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 529.0
TLS2_k127_418460_11 type II secretion system protein K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009307 497.0
TLS2_k127_418460_12 ATP dependent DNA ligase C terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 484.0
TLS2_k127_418460_13 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002605 477.0
TLS2_k127_418460_14 Pilus assembly protein CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 421.0
TLS2_k127_418460_15 COG0665 Glycine D-amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 429.0
TLS2_k127_418460_16 Oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003727 424.0
TLS2_k127_418460_17 CHASE4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007763 419.0
TLS2_k127_418460_18 pilus assembly protein TadB K12510 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 399.0
TLS2_k127_418460_19 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 377.0
TLS2_k127_418460_2 amino acid peptide transporter K03305 - - 6.682e-238 751.0
TLS2_k127_418460_20 SapC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 344.0
TLS2_k127_418460_21 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 333.0
TLS2_k127_418460_22 DNA ligase K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 330.0
TLS2_k127_418460_23 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 293.0
TLS2_k127_418460_24 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008147 294.0
TLS2_k127_418460_25 Lysophospholipase K01048 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 294.0
TLS2_k127_418460_26 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001006 280.0
TLS2_k127_418460_27 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000003169 252.0
TLS2_k127_418460_28 nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009175 245.0
TLS2_k127_418460_29 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000000000004089 219.0
TLS2_k127_418460_3 amidohydrolase - - - 1.526e-215 702.0
TLS2_k127_418460_30 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000000006127 207.0
TLS2_k127_418460_31 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000002782 209.0
TLS2_k127_418460_32 part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes K14987 - - 0.00000000000000000000000000000000000000000000000000000001693 205.0
TLS2_k127_418460_33 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000003478 190.0
TLS2_k127_418460_34 Serine aminopeptidase, S33 K06889 - - 0.000000000000000000000000000000000000000000000000004169 191.0
TLS2_k127_418460_35 peptidase K02278 - 3.4.23.43 0.000000000000000000000000000000000000000000001811 169.0
TLS2_k127_418460_36 Pilus assembly protein CpaD K02281 - - 0.000000000000000000000000000000000000000001143 172.0
TLS2_k127_418460_37 Transcriptional regulator K07979 - - 0.0000000000000000000000000000000000000004659 152.0
TLS2_k127_418460_38 MAPEG family - - - 0.000000000000000000000000000000000000001005 151.0
TLS2_k127_418460_39 BAAT / Acyl-CoA thioester hydrolase C terminal K06889 - - 0.000000000000000000000000000000000005433 150.0
TLS2_k127_418460_4 Aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704 1.2.1.3 3.131e-211 679.0
TLS2_k127_418460_40 - - - - 0.0000000000000000000000000000001366 129.0
TLS2_k127_418460_41 - - - - 0.00000000000000000000000000004269 122.0
TLS2_k127_418460_42 Heat shock protein - - - 0.000000000000000000000000000266 121.0
TLS2_k127_418460_43 - - - - 0.000000000000000000000000006593 111.0
TLS2_k127_418460_44 - - - - 0.000000000000001158 89.0
TLS2_k127_418460_45 DNA-binding helix-turn-helix protein K07729 - - 0.000000000001192 78.0
TLS2_k127_418460_5 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 607.0
TLS2_k127_418460_6 Belongs to the DEAD box helicase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 612.0
TLS2_k127_418460_7 FAD linked - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 597.0
TLS2_k127_418460_8 Flp pilus assembly protein, ATPase CpaE K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 582.0
TLS2_k127_418460_9 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 555.0
TLS2_k127_418991_0 receptor K02014 - - 0.0 1030.0
TLS2_k127_418991_1 Dienelactone hydrolase family - - - 7.716e-305 948.0
TLS2_k127_418991_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 500.0
TLS2_k127_418991_3 Aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 439.0
TLS2_k127_418991_4 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001182 258.0
TLS2_k127_418991_5 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000001189 150.0
TLS2_k127_418991_6 Methyltransferase domain - - - 0.000000000000000000000000000000002577 132.0
TLS2_k127_418991_7 Phosphate transport regulator K07220 - - 0.0000000000000000000000000000001702 132.0
TLS2_k127_4201580_0 Phosphotransferase K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 452.0
TLS2_k127_4201580_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 391.0
TLS2_k127_4201580_2 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 357.0
TLS2_k127_4201580_3 ATPase or kinase K06925 - - 0.00000000000000000000000000000000000000000000000008609 181.0
TLS2_k127_4206776_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 462.0
TLS2_k127_4206776_1 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 426.0
TLS2_k127_4206776_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000009947 251.0
TLS2_k127_4224262_0 belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 8.912e-214 677.0
TLS2_k127_4224262_1 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 329.0
TLS2_k127_4224262_2 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000001604 184.0
TLS2_k127_4224262_3 - - - - 0.0000000000000000000000000000000004814 143.0
TLS2_k127_4224262_4 - - - - 0.00000000000000000000000002242 122.0
TLS2_k127_4298569_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1039.0
TLS2_k127_4339740_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1077.0
TLS2_k127_4339740_1 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 1.436e-271 850.0
TLS2_k127_4339740_10 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000000000000000000000000000005656 216.0
TLS2_k127_4339740_11 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000004738 155.0
TLS2_k127_4339740_12 Domain of unknown function (DUF2383) - - - 0.000000000000000000000000000000000000006429 152.0
TLS2_k127_4339740_13 Belongs to the BolA IbaG family K05527 - - 0.0000000000000000000000000000000000000446 144.0
TLS2_k127_4339740_14 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000001161 144.0
TLS2_k127_4339740_15 EpsG family - - - 0.0000000000000000000000000001186 130.0
TLS2_k127_4339740_16 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000002466 84.0
TLS2_k127_4339740_17 Putative Flp pilus-assembly TadE/G-like - - - 0.00000002818 63.0
TLS2_k127_4339740_18 Resolvase - - - 0.000001831 56.0
TLS2_k127_4339740_2 Aerobic cobaltochelatase subunit CobS K09882 - 6.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 538.0
TLS2_k127_4339740_3 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 494.0
TLS2_k127_4339740_4 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 457.0
TLS2_k127_4339740_5 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 392.0
TLS2_k127_4339740_6 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003359 347.0
TLS2_k127_4339740_7 ribonuclease E activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 340.0
TLS2_k127_4339740_8 molecular chaperone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000673 280.0
TLS2_k127_4339740_9 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007725 259.0
TLS2_k127_4377113_0 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 368.0
TLS2_k127_4377113_1 Forkhead associated domain K11913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006511 293.0
TLS2_k127_4377113_2 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000003154 226.0
TLS2_k127_4377113_3 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.000000000000000000000000000000000003139 147.0
TLS2_k127_4392964_0 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000000009063 233.0
TLS2_k127_4392964_1 Belongs to the UPF0260 family K09160 - - 0.00000000000000000000000000000000000000000000000000000000000000001004 228.0
TLS2_k127_4392964_2 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001661 229.0
TLS2_k127_4392964_3 DNA repair protein MmcB-like - - - 0.000000000000000000000000000000000000000000000000000000000000008665 219.0
TLS2_k127_4392964_4 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000000000000009623 195.0
TLS2_k127_4392964_5 Ankyrin repeat - - - 0.0000000000000000000000000000000000000000000009195 174.0
TLS2_k127_4392964_6 COG3773 Cell wall hydrolyses involved in spore germination - - - 0.0000000000000000000000000000000000000000000233 171.0
TLS2_k127_4392964_7 Protein of unknown function (DUF1491) - - - 0.00000000000000000000000000002853 123.0
TLS2_k127_4392964_8 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.000000000000001163 77.0
TLS2_k127_4399992_0 Penicillin-binding Protein K05515 - 3.4.16.4 8.939e-232 748.0
TLS2_k127_4399992_1 rod shape-determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008139 583.0
TLS2_k127_4399992_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 475.0
TLS2_k127_4399992_3 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001726 284.0
TLS2_k127_4399992_4 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000000000000008589 150.0
TLS2_k127_4399992_5 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 0.0002649 53.0
TLS2_k127_4399992_6 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0004742 44.0
TLS2_k127_4452839_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 475.0
TLS2_k127_4452839_1 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 422.0
TLS2_k127_4452839_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001541 276.0
TLS2_k127_4452839_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.000000000000000000000000000000000000000000000000000000000000000002552 236.0
TLS2_k127_4452839_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000001455 176.0
TLS2_k127_4452839_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000001456 96.0
TLS2_k127_4460245_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 549.0
TLS2_k127_4460245_1 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 475.0
TLS2_k127_4460245_2 Domain of unknown function (DUF389) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003804 470.0
TLS2_k127_4460245_3 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 408.0
TLS2_k127_4460245_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000002347 76.0
TLS2_k127_4511088_0 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 578.0
TLS2_k127_4514862_0 helicase K03724 - - 0.0 1213.0
TLS2_k127_4514862_1 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 542.0
TLS2_k127_4514862_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000003921 213.0
TLS2_k127_4514862_3 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000006976 74.0
TLS2_k127_452829_0 Amidohydrolase family - - - 2.976e-228 719.0
TLS2_k127_452829_1 Helicase K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 347.0
TLS2_k127_452829_2 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000000000000000000009166 228.0
TLS2_k127_452829_3 phosphohistidine phosphatase K08296 - - 0.00000000000000000000000000000000001302 142.0
TLS2_k127_452829_4 WD40-like Beta Propeller Repeat - - - 0.00000000000000000008724 101.0
TLS2_k127_462576_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0 1098.0
TLS2_k127_462576_1 Domain of unknown function (DUF4115) - - - 0.0000000000000000007326 90.0
TLS2_k127_462576_2 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.000000000001102 68.0
TLS2_k127_4689294_0 membrane K07148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 362.0
TLS2_k127_4689294_1 - - - - 0.000000000000000000000000000000000000000000000000000000000004532 221.0
TLS2_k127_4689294_2 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000006192 196.0
TLS2_k127_4689294_3 Patatin-like phospholipase K06900 - - 0.00000000000000000000000000000000000000000000000002856 192.0
TLS2_k127_4689294_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000008191 192.0
TLS2_k127_4689294_5 Activator of Hsp90 ATPase family protein 3 - - - 0.0000000000000000000000000000000000000000000001592 178.0
TLS2_k127_4689294_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000002294 130.0
TLS2_k127_4689294_7 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.0000002885 58.0
TLS2_k127_4689294_8 Activator of Hsp90 ATPase family protein 3 - - - 0.00002133 50.0
TLS2_k127_4714108_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1372.0
TLS2_k127_4714108_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1112.0
TLS2_k127_4714108_10 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 439.0
TLS2_k127_4714108_11 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 433.0
TLS2_k127_4714108_12 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 406.0
TLS2_k127_4714108_13 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 361.0
TLS2_k127_4714108_14 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 340.0
TLS2_k127_4714108_15 Elongation factor G, domain IV K02355 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 327.0
TLS2_k127_4714108_16 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 336.0
TLS2_k127_4714108_17 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 318.0
TLS2_k127_4714108_18 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 295.0
TLS2_k127_4714108_19 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000002299 251.0
TLS2_k127_4714108_2 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 2.273e-276 864.0
TLS2_k127_4714108_20 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000579 208.0
TLS2_k127_4714108_21 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000002504 151.0
TLS2_k127_4714108_22 Outer membrane protein (OmpH-like) - - - 0.000000000000000000000000000000002376 137.0
TLS2_k127_4714108_23 periplasmic binding protein K02016 - - 0.00000000000000000000000000002692 121.0
TLS2_k127_4714108_24 cytochrome - - - 0.000000000000000000000002026 117.0
TLS2_k127_4714108_25 - - - - 0.00001954 53.0
TLS2_k127_4714108_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 6.067e-241 757.0
TLS2_k127_4714108_4 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 3.056e-237 740.0
TLS2_k127_4714108_5 Alkaline phosphatase K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 611.0
TLS2_k127_4714108_6 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 505.0
TLS2_k127_4714108_7 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 500.0
TLS2_k127_4714108_8 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 475.0
TLS2_k127_4714108_9 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 463.0
TLS2_k127_4722259_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.355e-209 678.0
TLS2_k127_4722259_1 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 4.078e-206 648.0
TLS2_k127_4722259_10 - - - - 0.000000000000782 74.0
TLS2_k127_4722259_2 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008542 532.0
TLS2_k127_4722259_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 476.0
TLS2_k127_4722259_4 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 360.0
TLS2_k127_4722259_5 glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001527 277.0
TLS2_k127_4722259_6 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000173 278.0
TLS2_k127_4722259_7 membrane - - - 0.00000000000000000000000000000000000000000000000000008513 188.0
TLS2_k127_4722259_8 GIY-YIG catalytic domain - - - 0.0000000000000000000000009243 106.0
TLS2_k127_4722259_9 gag-polyprotein putative aspartyl protease - - - 0.00000000000001365 82.0
TLS2_k127_4727582_0 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 420.0
TLS2_k127_4727582_1 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 322.0
TLS2_k127_4727582_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007058 317.0
TLS2_k127_4727582_3 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000174 147.0
TLS2_k127_4727582_4 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.0000000000000000000000000000000000003504 152.0
TLS2_k127_4731455_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 593.0
TLS2_k127_4731455_1 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 453.0
TLS2_k127_4731455_2 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008146 332.0
TLS2_k127_4731455_3 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000009801 169.0
TLS2_k127_4731455_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000005777 166.0
TLS2_k127_4763862_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 2.006e-292 906.0
TLS2_k127_4763862_1 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 1.73e-250 784.0
TLS2_k127_4763862_10 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000001275 212.0
TLS2_k127_4763862_11 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000000000000000000000000000000166 224.0
TLS2_k127_4763862_12 Regulatory protein RecX K03565 - - 0.000000000000000000000000000000000000000000000001975 179.0
TLS2_k127_4763862_13 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.00000000000000000000000000000000000000000000005686 172.0
TLS2_k127_4763862_14 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.000000000000000000000000000000000000000000008532 168.0
TLS2_k127_4763862_15 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000000000000003291 171.0
TLS2_k127_4763862_16 ArsC family K00537 - 1.20.4.1 0.000000000000000000000000000000000003928 145.0
TLS2_k127_4763862_17 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000003279 112.0
TLS2_k127_4763862_18 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000000000000006223 89.0
TLS2_k127_4763862_19 - - - - 0.000000000001858 78.0
TLS2_k127_4763862_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 1.536e-208 660.0
TLS2_k127_4763862_3 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 601.0
TLS2_k127_4763862_4 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 458.0
TLS2_k127_4763862_5 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008487 384.0
TLS2_k127_4763862_6 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 321.0
TLS2_k127_4763862_7 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008146 273.0
TLS2_k127_4763862_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008376 256.0
TLS2_k127_4763862_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000009327 237.0
TLS2_k127_4764177_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.554e-210 661.0
TLS2_k127_4764177_1 - - - - 0.00000000000000000000000000004051 125.0
TLS2_k127_4764177_2 Protein of unknown function (DUF3618) - - - 0.00000000001071 73.0
TLS2_k127_4764177_3 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000007287 60.0
TLS2_k127_4794777_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1246.0
TLS2_k127_4794777_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1055.0
TLS2_k127_4794777_10 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000005783 225.0
TLS2_k127_4794777_11 - - - - 0.00000000000000000000000000000000001862 140.0
TLS2_k127_4794777_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000000001724 124.0
TLS2_k127_4794777_13 - - - - 0.0000000000000000000000000002649 115.0
TLS2_k127_4794777_14 - - - - 0.000000000000000000000001191 105.0
TLS2_k127_4794777_15 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000007317 98.0
TLS2_k127_4794777_16 BFD-like [2Fe-2S] binding domain K02192 - - 0.0000000000000000008713 87.0
TLS2_k127_4794777_17 Protein of unknown function (DUF3309) - - - 0.000000000000000002882 90.0
TLS2_k127_4794777_18 Cytochrome c' - - - 0.0000000000001843 78.0
TLS2_k127_4794777_19 KTSC domain - - - 0.0000000000003593 76.0
TLS2_k127_4794777_2 Reductase C-terminal K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002752 516.0
TLS2_k127_4794777_21 - - - - 0.00001934 48.0
TLS2_k127_4794777_3 In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 424.0
TLS2_k127_4794777_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 389.0
TLS2_k127_4794777_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 376.0
TLS2_k127_4794777_6 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 369.0
TLS2_k127_4794777_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006434 346.0
TLS2_k127_4794777_8 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001126 289.0
TLS2_k127_4794777_9 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000753 248.0
TLS2_k127_4814968_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1132.0
TLS2_k127_4814968_1 Participates in both transcription termination and antitermination K02600 - - 2.369e-276 861.0
TLS2_k127_4814968_2 protein conserved in bacteria K09973 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002307 267.0
TLS2_k127_4814968_3 Nucleic-acid-binding protein K07742 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001626 255.0
TLS2_k127_4814968_4 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000000000000000000000000000000001333 230.0
TLS2_k127_4814968_5 succinate dehydrogenase K00241 - - 0.00000000000000000000000000000000000000000000001074 179.0
TLS2_k127_4814968_6 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000005637 164.0
TLS2_k127_4814968_7 succinate dehydrogenase K00242 - - 0.000000000000000000000000000001125 135.0
TLS2_k127_4814968_8 Transcriptional regulator K07729 - - 0.00000000000000000000000000003657 118.0
TLS2_k127_4814968_9 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000001043 59.0
TLS2_k127_4852894_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 9.829e-240 754.0
TLS2_k127_4852894_1 RarD protein K05786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 313.0
TLS2_k127_4852894_2 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000691 236.0
TLS2_k127_4852894_3 - - - - 0.0000000000000000000000000000001592 143.0
TLS2_k127_4852894_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000006605 99.0
TLS2_k127_4852894_5 - - - - 0.00000000000004106 78.0
TLS2_k127_4852894_6 - - - - 0.0000000000001698 76.0
TLS2_k127_4852894_8 - - - - 0.00000004816 58.0
TLS2_k127_4888441_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0 1005.0
TLS2_k127_4888441_1 dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 534.0
TLS2_k127_4888441_2 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009688 282.0
TLS2_k127_4888441_3 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.000000000000000000000000000000000000000000000000000000000000000000006329 243.0
TLS2_k127_4888441_4 Belongs to the CinA family K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000001376 214.0
TLS2_k127_4888441_5 Hemerythrin - - - 0.0000000000000000000000000000000000000000000000000001485 192.0
TLS2_k127_4888441_6 - - - - 0.0000000000000000000000000000000000003117 147.0
TLS2_k127_4888441_7 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111,K21054 - 1.1.1.402,1.1.5.3 0.00000000000000000000008991 99.0
TLS2_k127_4888441_8 - - - - 0.000000003668 62.0
TLS2_k127_4916762_0 Domain of unknown function (DUF305) - - - 0.0 1077.0
TLS2_k127_4916762_1 radical SAM domain protein - - - 4.64e-201 638.0
TLS2_k127_4916762_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 601.0
TLS2_k127_4916762_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006099 297.0
TLS2_k127_4916762_4 MobA-like NTP transferase domain K07281 - 2.7.7.74 0.000000000000000000000000000000000000000000000000000000000000000001865 236.0
TLS2_k127_4916762_5 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.0000000000000000000000000000000000000009777 154.0
TLS2_k127_4916762_6 Inositol-3-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000809 83.0
TLS2_k127_4929310_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 595.0
TLS2_k127_4929310_1 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 556.0
TLS2_k127_4942641_0 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 595.0
TLS2_k127_4942641_1 Glycosyl transferase family 2 K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 343.0
TLS2_k127_4942641_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002069 295.0
TLS2_k127_4971007_0 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 507.0
TLS2_k127_4971007_1 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000005752 217.0
TLS2_k127_4971007_2 protein conserved in bacteria - - - 0.0000000000000000000000000000004061 125.0
TLS2_k127_5003646_0 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 1.17e-211 676.0
TLS2_k127_5003646_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003335 577.0
TLS2_k127_5003646_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 340.0
TLS2_k127_5003646_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001074 272.0
TLS2_k127_5003646_4 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000005079 225.0
TLS2_k127_5003646_5 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.00000000000000000000000000000000000000000000000000000239 196.0
TLS2_k127_5022307_0 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000000005285 175.0
TLS2_k127_5022307_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000003776 103.0
TLS2_k127_5022307_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000002812 64.0
TLS2_k127_5022307_3 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000002973 55.0
TLS2_k127_5257239_0 Saccharopine dehydrogenase K00290 - 1.5.1.7 8.916e-212 663.0
TLS2_k127_5257239_1 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 9.817e-203 637.0
TLS2_k127_5257239_2 Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily K13747 - 4.1.1.96 0.0000000000000000000000000000000000000000000000002864 181.0
TLS2_k127_5289295_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1050.0
TLS2_k127_5289295_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 611.0
TLS2_k127_5289295_10 Protein of unknown function (DUF2459) - - - 0.0000000000000000000000000000000000000000000000000000003739 210.0
TLS2_k127_5289295_11 MerC mercury resistance protein - - - 0.0000000000000000000000000000000000000004468 152.0
TLS2_k127_5289295_12 - - - - 0.000729 44.0
TLS2_k127_5289295_2 Cysteine synthase K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 604.0
TLS2_k127_5289295_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 519.0
TLS2_k127_5289295_4 RND efflux system, outer membrane lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 477.0
TLS2_k127_5289295_5 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 355.0
TLS2_k127_5289295_6 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 334.0
TLS2_k127_5289295_7 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003642 269.0
TLS2_k127_5289295_8 Urate oxidase N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004749 242.0
TLS2_k127_5289295_9 Belongs to the Fur family K09823 - - 0.00000000000000000000000000000000000000000000000000000000000000000002503 235.0
TLS2_k127_531_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 1.282e-198 622.0
TLS2_k127_531_1 Putative diguanylate phosphodiesterase - - - 4.61e-196 631.0
TLS2_k127_531_2 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 506.0
TLS2_k127_531_3 Major facilitator superfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 381.0
TLS2_k127_531_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 365.0
TLS2_k127_531_5 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 329.0
TLS2_k127_531_6 COG1073 hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000412 251.0
TLS2_k127_531_7 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0000000000000000000000000000002703 125.0
TLS2_k127_531_8 Elongation factor G, domain IV K02355 - - 0.000000000000000000000000001144 112.0
TLS2_k127_5393230_0 Major Facilitator Superfamily K03301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 453.0
TLS2_k127_5393230_1 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 317.0
TLS2_k127_5393230_2 Ubiquinone biosynthesis protein COQ7 K06134 - - 0.000000000000000000000000000000000000000000000000000000000111 208.0
TLS2_k127_5393230_3 Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000000000000002054 215.0
TLS2_k127_5393230_4 Gram-negative bacterial TonB protein C-terminal - - - 0.000000000000000000000000000000000000000000000000000001338 214.0
TLS2_k127_5393230_5 helix_turn_helix, cAMP Regulatory protein - - - 0.000000000000000000000000000000000000000000000004692 182.0
TLS2_k127_5393230_6 PRC-barrel domain - - - 0.000000000000000000000000001031 118.0
TLS2_k127_5433528_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 536.0
TLS2_k127_5433528_1 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 400.0
TLS2_k127_5455753_0 peptidase K07386 - - 0.0 1035.0
TLS2_k127_5455753_1 asparagine synthase - - - 3.235e-215 683.0
TLS2_k127_5455753_10 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 319.0
TLS2_k127_5455753_11 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000009536 229.0
TLS2_k127_5455753_12 PFAM glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000000000000000000000000000374 201.0
TLS2_k127_5455753_13 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000002452 143.0
TLS2_k127_5455753_14 YjbR - - - 0.00000000000000000000000000001179 122.0
TLS2_k127_5455753_15 - - - - 0.0000000002397 63.0
TLS2_k127_5455753_16 - - - - 0.00004249 47.0
TLS2_k127_5455753_2 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 599.0
TLS2_k127_5455753_3 COG3307 Lipid A core - O-antigen ligase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 538.0
TLS2_k127_5455753_4 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 498.0
TLS2_k127_5455753_5 Belongs to the glutaminase family K01425 - 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 403.0
TLS2_k127_5455753_6 DNA topoisomerase K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 394.0
TLS2_k127_5455753_7 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 374.0
TLS2_k127_5455753_8 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 345.0
TLS2_k127_5455753_9 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006611 344.0
TLS2_k127_5458486_0 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006536 265.0
TLS2_k127_5458486_1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000001009 231.0
TLS2_k127_5458486_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000001349 227.0
TLS2_k127_5458486_3 Protein of unknown function (DUF1294) - - - 0.000000000000000000000005212 112.0
TLS2_k127_5458486_4 tRNA (guanine-N7-)-methyltransferase activity - - - 0.000000000000008124 76.0
TLS2_k127_5458486_5 - - - - 0.000000001273 65.0
TLS2_k127_5458486_6 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000005504 54.0
TLS2_k127_5458486_7 luxR family - - - 0.00004319 48.0
TLS2_k127_5489493_0 TonB dependent receptor K16090 - - 1.874e-210 668.0
TLS2_k127_5489493_1 metalloprotease K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 322.0
TLS2_k127_5489493_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004982 290.0
TLS2_k127_5489493_3 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00005724 46.0
TLS2_k127_5516192_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009224 385.0
TLS2_k127_5516192_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 353.0
TLS2_k127_5516192_2 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 312.0
TLS2_k127_5516192_3 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000002259 203.0
TLS2_k127_5516192_4 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000000000000000000000001043 170.0
TLS2_k127_5516192_5 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000001785 112.0
TLS2_k127_5559199_0 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005346 381.0
TLS2_k127_5559199_1 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000001046 165.0
TLS2_k127_5559199_2 Cell Wall Hydrolase - - - 0.0000000000000000000003964 103.0
TLS2_k127_5559199_3 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000001178 76.0
TLS2_k127_5584454_0 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 532.0
TLS2_k127_5584454_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 369.0
TLS2_k127_5584454_2 - - - - 0.000000000000000000000000000000000000000000000000000008768 206.0
TLS2_k127_5584454_3 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000008099 187.0
TLS2_k127_5584454_4 - - - - 0.0000000000000000000000007745 111.0
TLS2_k127_5610906_0 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 293.0
TLS2_k127_5610906_1 Putative methyltransferase K13623 - - 0.0000000000000000000000000529 117.0
TLS2_k127_5610906_2 TIGRFAM death-on-curing family protein K07341 - - 0.00000000000000000002269 95.0
TLS2_k127_5610906_3 Putative methyltransferase K13623 - - 0.0000000000000000000968 99.0
TLS2_k127_5610906_4 Catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate K00046 - 1.1.1.69 0.000000000006262 66.0
TLS2_k127_5638588_0 argininosuccinate lyase K01755 - 4.3.2.1 4.491e-212 669.0
TLS2_k127_5638588_1 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 441.0
TLS2_k127_5638588_2 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 425.0
TLS2_k127_5638588_3 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 409.0
TLS2_k127_5638588_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 324.0
TLS2_k127_5638588_5 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 297.0
TLS2_k127_5638588_6 Redoxin - - - 0.0000000000000000000000000000000000000000000000000003695 192.0
TLS2_k127_5638588_7 HNH endonuclease - - - 0.000000000000000006205 83.0
TLS2_k127_5638588_8 - - - - 0.000000000000002413 80.0
TLS2_k127_5642663_0 Circularly permuted ATP-grasp type 2 - - - 1.529e-217 692.0
TLS2_k127_5642663_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009471 443.0
TLS2_k127_5642663_2 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 371.0
TLS2_k127_5642663_3 Pseudouridine synthase K06177 - 5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007803 284.0
TLS2_k127_5642663_4 Bacterial transglutaminase-like N-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003853 286.0
TLS2_k127_5642663_5 chain release factor K15034 - - 0.000000000000000000000000000000000000000005779 158.0
TLS2_k127_5642949_0 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004736 324.0
TLS2_k127_5642949_1 Parallel beta-helix repeats - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001743 262.0
TLS2_k127_5663103_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 1.563e-224 719.0
TLS2_k127_5663103_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.959e-209 655.0
TLS2_k127_5663103_10 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000007863 264.0
TLS2_k127_5663103_11 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.0000000000000000000000000000000000000000000000000000000000000000001443 241.0
TLS2_k127_5663103_12 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000000000000000000000000000002601 232.0
TLS2_k127_5663103_13 membrane - - - 0.0000000000000000000000000000000000000000000000000000000008797 212.0
TLS2_k127_5663103_14 thioesterase K07107 - - 0.000000000000000000000000000000000000000000000000000000005855 203.0
TLS2_k127_5663103_15 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000000000001245 196.0
TLS2_k127_5663103_16 Biopolymer transport protein K03560 - - 0.0000000000000000000000000000000000000000004765 166.0
TLS2_k127_5663103_17 Lytic murein transglycosylase - - - 0.000000000000000000000000000004556 132.0
TLS2_k127_5663103_18 - - - - 0.00000000000000000001667 92.0
TLS2_k127_5663103_19 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000008247 51.0
TLS2_k127_5663103_2 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005546 610.0
TLS2_k127_5663103_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 570.0
TLS2_k127_5663103_4 Asparaginase K13051 - 3.4.19.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 439.0
TLS2_k127_5663103_5 Protein of unknown function (DUF3089) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 395.0
TLS2_k127_5663103_6 S1/P1 Nuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 377.0
TLS2_k127_5663103_7 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 364.0
TLS2_k127_5663103_8 MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006942 326.0
TLS2_k127_5663103_9 EamA-like transporter family K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 308.0
TLS2_k127_5687084_0 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 437.0
TLS2_k127_5687084_1 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 299.0
TLS2_k127_5687084_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006997 259.0
TLS2_k127_5687084_4 Pyridoxamine 5'-phosphate oxidase like - - - 0.0000000000002243 74.0
TLS2_k127_5687084_5 - - - - 0.00002852 48.0
TLS2_k127_5752897_0 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009842 349.0
TLS2_k127_5752897_1 COG0694 Thioredoxin-like proteins and domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 289.0
TLS2_k127_5752897_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000003868 223.0
TLS2_k127_5752897_3 peptidase M22 - - - 0.000000000000000000000000000000000000000000000000000000000000001458 224.0
TLS2_k127_5752897_4 Acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000000001468 167.0
TLS2_k127_5752897_5 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000008044 159.0
TLS2_k127_5752897_6 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000008409 68.0
TLS2_k127_5774582_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1050.0
TLS2_k127_5774582_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 366.0
TLS2_k127_5774582_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 339.0
TLS2_k127_5774582_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 295.0
TLS2_k127_5774582_4 Protein of unknown function (DUF541) K09797 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002375 276.0
TLS2_k127_5774582_5 COG0346 Lactoylglutathione lyase and related lyases K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000222 234.0
TLS2_k127_5774582_6 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000001679 195.0
TLS2_k127_5784054_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 6.735e-265 825.0
TLS2_k127_5784054_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 535.0
TLS2_k127_5784054_2 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 504.0
TLS2_k127_5784054_3 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 404.0
TLS2_k127_5784054_4 Extensin-like protein C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 334.0
TLS2_k127_5784054_5 UMP catabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004102 282.0
TLS2_k127_5784054_6 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000007477 213.0
TLS2_k127_5795687_0 Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily K13747 - 4.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 490.0
TLS2_k127_5795687_1 MAPEG family - - - 0.0000000000000000000000000000000000000000000005076 171.0
TLS2_k127_580110_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1519.0
TLS2_k127_5801495_0 PFAM AMP-dependent synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 475.0
TLS2_k127_5801495_1 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007549 312.0
TLS2_k127_5801495_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003147 241.0
TLS2_k127_5801495_3 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000008548 107.0
TLS2_k127_5801495_4 - - - - 0.000000000000000001068 89.0
TLS2_k127_5801495_5 - - - - 0.0000001528 55.0
TLS2_k127_5801495_6 Alpha/beta hydrolase family - - - 0.0000003262 52.0
TLS2_k127_5847345_0 N-carbamoylputrescine amidase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 488.0
TLS2_k127_5847345_1 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 409.0
TLS2_k127_5847345_2 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 321.0
TLS2_k127_5847345_3 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000003723 192.0
TLS2_k127_5897976_0 Efflux pump membrane transporter K18138 - - 0.0 1349.0
TLS2_k127_5897976_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 297.0
TLS2_k127_5897976_2 Putative bacterial sensory transduction regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001594 277.0
TLS2_k127_5897976_3 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.000000000000000000000000000000000000000000000000000000000000001114 224.0
TLS2_k127_5897976_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000001799 173.0
TLS2_k127_5897976_5 Membrane fusogenic activity K09806 - - 0.0000000000000000000002879 98.0
TLS2_k127_5939662_0 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 604.0
TLS2_k127_5939662_1 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 299.0
TLS2_k127_5939662_2 NlpC/P60 family - - - 0.000000000000000000000000000000000000000000000000000000000000000004153 237.0
TLS2_k127_5939662_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000001946 177.0
TLS2_k127_5939662_4 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000004843 162.0
TLS2_k127_5939662_5 - - - - 0.0000000000000000000000000000000006826 136.0
TLS2_k127_5939662_7 Pyrimidine nucleoside phosphorylase C-terminal domain - - - 0.000000003542 58.0
TLS2_k127_5981911_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 2.97e-285 887.0
TLS2_k127_5981911_1 Histidine kinase K14980 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 611.0
TLS2_k127_5981911_11 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.0000000000000000000000004136 113.0
TLS2_k127_5981911_12 META domain - - - 0.00000000000000000000002229 103.0
TLS2_k127_5981911_2 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 494.0
TLS2_k127_5981911_3 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 412.0
TLS2_k127_5981911_4 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 378.0
TLS2_k127_5981911_5 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.00000000000000000000000000000000000000000000000000000000000001546 218.0
TLS2_k127_5981911_6 - - - - 0.00000000000000000000000000000000000000000000000000003528 194.0
TLS2_k127_5981911_7 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.0000000000000000000000000000000000000000000000002632 181.0
TLS2_k127_5981911_8 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.00000000000000000000000000000000000000000000001191 177.0
TLS2_k127_5981911_9 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000003663 163.0
TLS2_k127_6004844_0 Helicase K03722 - 3.6.4.12 0.0 1051.0
TLS2_k127_6004844_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 2.084e-237 743.0
TLS2_k127_6040353_0 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 497.0
TLS2_k127_6040353_1 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000934 488.0
TLS2_k127_6040353_2 PFAM GtrA family protein - - - 0.00000000000000000000000000000000000000002266 156.0
TLS2_k127_6040353_3 Methyltransferase domain - - - 0.0000000000000000007393 86.0
TLS2_k127_6048822_0 Protein conserved in bacteria - - - 8.179e-262 821.0
TLS2_k127_6048822_1 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 504.0
TLS2_k127_6048822_2 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.000000000000000000000000000000000000000000000000000000000000000000001581 242.0
TLS2_k127_6069524_0 COG0729 Outer membrane protein K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 554.0
TLS2_k127_6084469_0 Glycine dehydrogenase (aminomethyl-transferring) K00283 - 1.4.4.2 7.063e-270 844.0
TLS2_k127_6084469_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 3.611e-223 700.0
TLS2_k127_6084469_2 Glycine cleavage system T protein K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 521.0
TLS2_k127_6084469_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008122 431.0
TLS2_k127_6084469_4 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 306.0
TLS2_k127_6084469_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001075 234.0
TLS2_k127_6084469_6 membrane - - - 0.00000000000000000000000000000000000000000000000000000000004632 218.0
TLS2_k127_6084469_7 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000006319 184.0
TLS2_k127_6084469_8 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000006731 186.0
TLS2_k127_6084469_9 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.000000000000001429 81.0
TLS2_k127_614312_0 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000003389 151.0
TLS2_k127_614312_1 - - - - 0.0000000000000000003181 98.0
TLS2_k127_6163594_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1328.0
TLS2_k127_6163594_1 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 468.0
TLS2_k127_6163594_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 454.0
TLS2_k127_6163594_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 413.0
TLS2_k127_6163594_4 Belongs to the AAA ATPase family K13525 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 297.0
TLS2_k127_6163594_5 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001985 285.0
TLS2_k127_6178767_0 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.00000000000000000000002859 114.0
TLS2_k127_6178767_1 HemY protein N-terminus K02498 - - 0.00000002837 57.0
TLS2_k127_6231463_0 Catalyzes the NAD( )-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non- methylotrophic organisms K00122 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 506.0
TLS2_k127_6231463_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000243 173.0
TLS2_k127_6231463_2 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K00663,K03790 - 2.3.1.128,2.3.1.82 0.00000000000000000000000006103 115.0
TLS2_k127_6231463_3 - - - - 0.0000000000000002369 81.0
TLS2_k127_6289821_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 4.167e-227 705.0
TLS2_k127_6289821_1 - - - - 0.0000000000000000000000000000000001035 140.0
TLS2_k127_6303245_0 AbgT putative transporter family K12942 - - 1.97e-242 762.0
TLS2_k127_6303245_1 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 565.0
TLS2_k127_6303245_10 Cell Wall - - - 0.0000000000000000000000000000000000000000000000000000000001322 214.0
TLS2_k127_6303245_11 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000000006612 187.0
TLS2_k127_6303245_12 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000001176 193.0
TLS2_k127_6303245_13 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000000000003784 198.0
TLS2_k127_6303245_14 PFAM SWIB MDM2 domain - - - 0.000000000000000000000000000000001884 132.0
TLS2_k127_6303245_15 Penicillinase repressor - - - 0.0000000000000000000000000000006947 125.0
TLS2_k127_6303245_16 Methyltransferase - - - 0.000000000000000000000000000009929 119.0
TLS2_k127_6303245_17 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000008282 100.0
TLS2_k127_6303245_18 - - - - 0.000008002 56.0
TLS2_k127_6303245_2 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 441.0
TLS2_k127_6303245_3 Chalcone and stilbene synthases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 427.0
TLS2_k127_6303245_4 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 364.0
TLS2_k127_6303245_5 proteins, homologs of microcin C7 resistance protein MccF K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 349.0
TLS2_k127_6303245_6 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 352.0
TLS2_k127_6303245_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 327.0
TLS2_k127_6303245_8 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 309.0
TLS2_k127_6303245_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007165 290.0
TLS2_k127_6337893_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 3.917e-216 678.0
TLS2_k127_6337893_1 DoxX K15977 - - 0.0000000000000000000000000000000000000000000006162 170.0
TLS2_k127_6349395_0 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 387.0
TLS2_k127_6349395_1 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 373.0
TLS2_k127_6367049_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004602 355.0
TLS2_k127_6367049_1 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007655 317.0
TLS2_k127_6367049_2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009775 299.0
TLS2_k127_6367049_3 Membrane-bound metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001372 293.0
TLS2_k127_6367049_4 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000000005845 209.0
TLS2_k127_6367049_5 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000000000007899 189.0
TLS2_k127_6392980_0 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000001328 248.0
TLS2_k127_6392980_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000009026 248.0
TLS2_k127_6392980_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000005958 74.0
TLS2_k127_6415586_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 1.526e-244 767.0
TLS2_k127_6415586_1 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000001192 224.0
TLS2_k127_6420690_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 523.0
TLS2_k127_6420690_1 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 428.0
TLS2_k127_6420690_2 Cupin superfamily protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 407.0
TLS2_k127_6420690_3 GTP cyclohydrolase K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 365.0
TLS2_k127_6420690_4 Serine/threonine phosphatases, family 2C, catalytic domain K11915 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000748 273.0
TLS2_k127_6420690_5 Protein of unknown function (DUF3775) - - - 0.00000000000000000000000000000000000000000001859 167.0
TLS2_k127_6420690_6 2'-5' RNA ligase superfamily - - - 0.00001098 48.0
TLS2_k127_6433785_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 2.33e-221 715.0
TLS2_k127_6433785_1 PAS domain - - - 0.000000000000000001912 91.0
TLS2_k127_6543822_0 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000005682 214.0
TLS2_k127_6543822_1 sulfuric ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000003239 190.0
TLS2_k127_6543822_2 sulfuric ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000005503 192.0
TLS2_k127_6543822_3 glycosyl transferase group 1 - - - 0.000000000000000000000000000000002944 133.0
TLS2_k127_6543822_4 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000002935 88.0
TLS2_k127_6544792_0 epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 533.0
TLS2_k127_6544792_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474,K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005311 390.0
TLS2_k127_6544792_2 Bacterial sugar transferase K21303 - 2.7.8.40 0.00000000000000001528 90.0
TLS2_k127_6554466_0 Lead, cadmium, zinc and mercury transporting ATPase K17686 - 3.6.3.54 0.0 1013.0
TLS2_k127_6554466_1 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004745 369.0
TLS2_k127_6554466_2 Copper-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 336.0
TLS2_k127_6554466_3 helix_turn_helix, mercury resistance K19591 - - 0.000000000000000000000000000000000000001382 153.0
TLS2_k127_6559830_0 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 391.0
TLS2_k127_6559830_1 response regulator - - - 0.000000000000000000000000000000000000008534 150.0
TLS2_k127_6559830_2 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000004349 89.0
TLS2_k127_6592659_0 receptor K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004709 258.0
TLS2_k127_6592659_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000007475 178.0
TLS2_k127_6592659_2 50S ribosomal protein L31 K02909 - - 0.0000000000000000000000000000000000004286 141.0
TLS2_k127_6617795_0 Phytoene dehydrogenase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 2.634e-241 753.0
TLS2_k127_6617795_1 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 1.555e-209 655.0
TLS2_k127_6617795_10 Protein of unknown function (DUF1109) - - - 0.00000000000000000000000000000000000001642 154.0
TLS2_k127_6617795_11 Putative DNA-binding domain - - - 0.0000000000000000000000000000000001074 143.0
TLS2_k127_6617795_12 Integral membrane protein - - - 0.0000000000000000000000000005512 117.0
TLS2_k127_6617795_2 Lycopene cyclase protein K06443 - 5.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 403.0
TLS2_k127_6617795_3 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002091 365.0
TLS2_k127_6617795_4 Phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 358.0
TLS2_k127_6617795_5 Fatty acid hydroxylase superfamily K15746 - 1.14.15.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000557 281.0
TLS2_k127_6617795_6 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000006259 224.0
TLS2_k127_6617795_7 sterol desaturase - - - 0.000000000000000000000000000000000000000000000000000000000202 204.0
TLS2_k127_6617795_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000007131 175.0
TLS2_k127_6617795_9 PFAM DoxX family protein K15977 - - 0.000000000000000000000000000000000000000000007353 167.0
TLS2_k127_6626730_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 3.458e-228 715.0
TLS2_k127_6626730_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 3.288e-208 677.0
TLS2_k127_6626730_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 565.0
TLS2_k127_6626730_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004702 349.0
TLS2_k127_6626730_4 Colicin V production protein K03558 - - 0.000000000000000000000000000000000000000000000000002892 187.0
TLS2_k127_6626730_5 NifU homolog involved in Fe-S cluster formation - - - 0.000000000000000000000000000000000000000000000006659 189.0
TLS2_k127_6626730_6 - - - - 0.00000000000000000000000000000000000001693 148.0
TLS2_k127_6676911_0 Peptidase S46 - - - 8.735e-274 858.0
TLS2_k127_6676911_1 alcohol dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 497.0
TLS2_k127_6676911_10 HNH endonuclease - - - 0.000003179 53.0
TLS2_k127_6676911_2 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 436.0
TLS2_k127_6676911_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 399.0
TLS2_k127_6676911_4 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 354.0
TLS2_k127_6676911_5 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 354.0
TLS2_k127_6676911_6 PilZ domain - - - 0.000000000000000000000000000000000000000000000000000003912 204.0
TLS2_k127_6676911_7 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 0.000000000000000000000000000000000000008737 145.0
TLS2_k127_6676911_8 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000005219 107.0
TLS2_k127_6676911_9 - - - - 0.000000000005028 68.0
TLS2_k127_6689410_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1106.0
TLS2_k127_6689410_1 ABC transporter transmembrane region K06147 - - 2.132e-256 806.0
TLS2_k127_6689410_10 LysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000007909 225.0
TLS2_k127_6689410_11 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000009119 204.0
TLS2_k127_6689410_12 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000000000000000000000000000000000000000000001183 195.0
TLS2_k127_6689410_13 Peptidase family S41 - - - 0.00000000000000000000000000000000000004976 160.0
TLS2_k127_6689410_15 Protein of unknown function (DUF3297) - - - 0.0000000000000000000000000005595 123.0
TLS2_k127_6689410_16 - - - - 0.0000000000000001657 83.0
TLS2_k127_6689410_17 Biopolymer K03559 - - 0.000000005198 66.0
TLS2_k127_6689410_2 Protein conserved in bacteria - - - 4.587e-238 752.0
TLS2_k127_6689410_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 606.0
TLS2_k127_6689410_4 Amino-transferase class IV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 482.0
TLS2_k127_6689410_5 Branched-chain amino acid aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 331.0
TLS2_k127_6689410_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007474 287.0
TLS2_k127_6689410_7 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004426 249.0
TLS2_k127_6689410_8 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005154 244.0
TLS2_k127_6689410_9 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000000000000000002276 225.0
TLS2_k127_6695258_0 TonB dependent receptor - - - 0.0 1226.0
TLS2_k127_6695258_1 Histidine kinase - - - 3.816e-194 621.0
TLS2_k127_6695258_2 Aspartyl/Asparaginyl beta-hydroxylase K12979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002038 276.0
TLS2_k127_6695529_0 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 429.0
TLS2_k127_6695529_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 391.0
TLS2_k127_6695529_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 368.0
TLS2_k127_6712592_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 4192.0
TLS2_k127_6712592_1 Universal stress protein - - - 0.0000000000001338 74.0
TLS2_k127_6744997_0 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 1.845e-318 988.0
TLS2_k127_6744997_1 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001235 595.0
TLS2_k127_6744997_2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 493.0
TLS2_k127_6744997_3 enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 390.0
TLS2_k127_6744997_4 Belongs to the thiolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 343.0
TLS2_k127_6744997_5 Thioesterase superfamily K02614 - - 0.0000000000000000000000000000000000000000000000005719 178.0
TLS2_k127_6744997_6 CBS domain - - - 0.00000000000000000000000000000000000000000005735 170.0
TLS2_k127_6744997_7 Protein of unknown function (DUF1622) - - - 0.000000000000000000000000000000000000003095 150.0
TLS2_k127_6775670_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 441.0
TLS2_k127_6775670_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000925 336.0
TLS2_k127_6775670_10 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000003233 149.0
TLS2_k127_6775670_11 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000003511 145.0
TLS2_k127_6775670_12 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000001076 138.0
TLS2_k127_6775670_13 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000002715 111.0
TLS2_k127_6775670_14 Ribosomal protein L30 K02907 - - 0.000000000000000000000008015 106.0
TLS2_k127_6775670_15 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000000000000008156 98.0
TLS2_k127_6775670_2 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 332.0
TLS2_k127_6775670_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005839 294.0
TLS2_k127_6775670_4 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000073 264.0
TLS2_k127_6775670_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000000000008368 231.0
TLS2_k127_6775670_6 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000000162 230.0
TLS2_k127_6775670_7 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000001217 193.0
TLS2_k127_6775670_8 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000000000000000000000000000007297 172.0
TLS2_k127_6775670_9 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000000000005886 173.0
TLS2_k127_677794_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 507.0
TLS2_k127_677794_1 Carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 524.0
TLS2_k127_677794_2 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 384.0
TLS2_k127_677794_3 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007713 321.0
TLS2_k127_677794_4 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007198 293.0
TLS2_k127_677794_5 Lactoylglutathione lyase K07032 - - 0.00000000000000000000000000000000000000000000000000000000004329 208.0
TLS2_k127_677794_6 - - - - 0.0000000000000000000000000000000000000000000003027 174.0
TLS2_k127_677794_7 exodeoxyribonuclease III K01142 - 3.1.11.2 0.0000000000000000000000000000002517 130.0
TLS2_k127_677794_8 Protein of unknown function (DUF1428) - - - 0.0007555 45.0
TLS2_k127_6810384_0 helicase K17675 - 3.6.4.13 0.0 1043.0
TLS2_k127_6810384_1 Domain of unknown function DUF87 K06915 - - 4.435e-270 841.0
TLS2_k127_6810384_10 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000005198 264.0
TLS2_k127_6810384_11 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000000000000000000000006454 231.0
TLS2_k127_6810384_12 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000000000000000000000000000000000002601 186.0
TLS2_k127_6810384_13 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.000000000000000000000000000000000000002499 154.0
TLS2_k127_6810384_14 Protein of unknown function (DUF1489) - - - 0.0000000000000000000000000000000000001576 147.0
TLS2_k127_6810384_15 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000000000001413 118.0
TLS2_k127_6810384_16 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000000005367 107.0
TLS2_k127_6810384_17 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.000000000000000000000001903 107.0
TLS2_k127_6810384_18 - - - - 0.000000000000000000002162 100.0
TLS2_k127_6810384_2 Acts as a magnesium transporter K06213 - - 2.663e-209 661.0
TLS2_k127_6810384_3 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000686 560.0
TLS2_k127_6810384_4 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006827 421.0
TLS2_k127_6810384_5 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 384.0
TLS2_k127_6810384_6 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 332.0
TLS2_k127_6810384_7 CarD family transcriptional regulator K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 293.0
TLS2_k127_6810384_8 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 293.0
TLS2_k127_6810384_9 KR domain K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000267 277.0
TLS2_k127_6873228_0 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 319.0
TLS2_k127_6873228_1 Putative transposase of IS4/5 family (DUF4096) K07492 - - 0.000000000000000000000000000000000000000000000000000000000000001129 221.0
TLS2_k127_6873228_2 Transposase DDE domain K04655,K08303 - - 0.0000000000000000000000000000000000000000001934 167.0
TLS2_k127_6919463_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1401.0
TLS2_k127_6919463_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1090.0
TLS2_k127_6919463_10 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 3.937e-194 616.0
TLS2_k127_6919463_11 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 537.0
TLS2_k127_6919463_12 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 479.0
TLS2_k127_6919463_13 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 459.0
TLS2_k127_6919463_14 coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 461.0
TLS2_k127_6919463_15 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 437.0
TLS2_k127_6919463_16 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000647 440.0
TLS2_k127_6919463_17 Phosphate ABC transporter substrate-binding protein K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 416.0
TLS2_k127_6919463_18 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 415.0
TLS2_k127_6919463_19 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 403.0
TLS2_k127_6919463_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.414e-307 955.0
TLS2_k127_6919463_20 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 396.0
TLS2_k127_6919463_21 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 383.0
TLS2_k127_6919463_22 Cytochrome c1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 375.0
TLS2_k127_6919463_23 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 358.0
TLS2_k127_6919463_24 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 359.0
TLS2_k127_6919463_25 serine acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 353.0
TLS2_k127_6919463_26 Beta-lactamase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 345.0
TLS2_k127_6919463_27 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 323.0
TLS2_k127_6919463_28 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 317.0
TLS2_k127_6919463_29 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005869 314.0
TLS2_k127_6919463_3 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 1.589e-278 876.0
TLS2_k127_6919463_30 GcrA cell cycle regulator K13583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 308.0
TLS2_k127_6919463_31 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 301.0
TLS2_k127_6919463_32 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 301.0
TLS2_k127_6919463_33 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 295.0
TLS2_k127_6919463_34 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 296.0
TLS2_k127_6919463_35 Phosphoglycolate phosphatase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007036 293.0
TLS2_k127_6919463_36 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001822 266.0
TLS2_k127_6919463_37 protein conserved in bacteria K09973 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005735 263.0
TLS2_k127_6919463_38 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000001188 246.0
TLS2_k127_6919463_39 phosphate-selective porin K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000003134 233.0
TLS2_k127_6919463_4 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 1.947e-238 741.0
TLS2_k127_6919463_40 N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000002895 222.0
TLS2_k127_6919463_41 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000005923 207.0
TLS2_k127_6919463_42 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000005154 205.0
TLS2_k127_6919463_43 - - - - 0.00000000000000000000000000000000000000000000000000000002506 205.0
TLS2_k127_6919463_44 protein conserved in bacteria K09973 - - 0.00000000000000000000000000000000000000000000000001334 193.0
TLS2_k127_6919463_45 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000005144 163.0
TLS2_k127_6919463_46 Protein of unknown function (DUF2794) - - - 0.0000000000000000000000000000000000000002499 158.0
TLS2_k127_6919463_47 Protein of unknown function (DUF4087) - - - 0.0000000000000000000000000000000004646 134.0
TLS2_k127_6919463_48 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000004678 134.0
TLS2_k127_6919463_49 - - - - 0.000000000000000000000000004632 121.0
TLS2_k127_6919463_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 3.343e-204 645.0
TLS2_k127_6919463_50 - - - - 0.0000000000000000001514 96.0
TLS2_k127_6919463_51 - - - - 0.0000000000000000003692 101.0
TLS2_k127_6919463_52 - - - - 0.00000005823 60.0
TLS2_k127_6919463_53 - - - - 0.00001071 56.0
TLS2_k127_6919463_55 - - - - 0.0001618 50.0
TLS2_k127_6919463_6 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 8.581e-198 622.0
TLS2_k127_6919463_7 phosphate transport system permease K02038 - - 1.876e-196 620.0
TLS2_k127_6919463_8 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 5.017e-196 632.0
TLS2_k127_6919463_9 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 3.345e-194 610.0
TLS2_k127_6934716_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1086.0
TLS2_k127_6934716_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.096e-276 871.0
TLS2_k127_6934716_10 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000000000000000000000000000001524 241.0
TLS2_k127_6934716_11 Protein of unknown function (DUF1203) - - - 0.0000000000000000000000000000000000000000000000001102 182.0
TLS2_k127_6934716_12 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 - - 0.000000000000000000000000000000000004352 138.0
TLS2_k127_6934716_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000001337 137.0
TLS2_k127_6934716_14 - - - - 0.00000000000000000003129 92.0
TLS2_k127_6934716_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.323e-274 849.0
TLS2_k127_6934716_3 Flp pilus assembly protein, ATPase CpaF K02283 - - 3.563e-260 811.0
TLS2_k127_6934716_4 Metal binding domain of Ada K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003453 499.0
TLS2_k127_6934716_5 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 462.0
TLS2_k127_6934716_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 407.0
TLS2_k127_6934716_7 Hemolysin K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 370.0
TLS2_k127_6934716_8 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008805 315.0
TLS2_k127_6934716_9 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 291.0
TLS2_k127_694116_0 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 593.0
TLS2_k127_694116_1 DNA helicase K03654 - 3.6.4.12 0.0000000000000000000000004742 106.0
TLS2_k127_6947879_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.812e-300 948.0
TLS2_k127_6947879_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 440.0
TLS2_k127_6947879_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 405.0
TLS2_k127_6947879_3 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 391.0
TLS2_k127_6947879_4 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 399.0
TLS2_k127_6947879_5 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 359.0
TLS2_k127_6947879_6 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004926 277.0
TLS2_k127_6947879_7 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000000000000000000000000000000000000001949 218.0
TLS2_k127_6947879_8 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.0000000000000000000000000000000000000000000000000619 183.0
TLS2_k127_6954416_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1354.0
TLS2_k127_6954416_1 Lipopolysaccharide-assembly K03643 - - 0.0000000000000000000000000000000000000000000000000000004788 208.0
TLS2_k127_6955130_0 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009658 579.0
TLS2_k127_6955130_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 518.0
TLS2_k127_6955130_2 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 326.0
TLS2_k127_6955130_3 - - - - 0.0000000004883 70.0
TLS2_k127_6988742_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 1.906e-316 979.0
TLS2_k127_6988742_1 Belongs to the transketolase family K00615 - 2.2.1.1 4.088e-311 963.0
TLS2_k127_6988742_10 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 353.0
TLS2_k127_6988742_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008239 334.0
TLS2_k127_6988742_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 331.0
TLS2_k127_6988742_13 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 334.0
TLS2_k127_6988742_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000004007 195.0
TLS2_k127_6988742_15 Peptidase family M23 K21472 - - 0.00000000000000000000000000000000000000000000000000002686 194.0
TLS2_k127_6988742_16 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000000000000000000001065 184.0
TLS2_k127_6988742_17 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000004858 183.0
TLS2_k127_6988742_18 Mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000000000000004664 179.0
TLS2_k127_6988742_19 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000003608 115.0
TLS2_k127_6988742_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.359e-254 788.0
TLS2_k127_6988742_20 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000005101 113.0
TLS2_k127_6988742_21 Cytochrome c - - - 0.00000000000000000004362 93.0
TLS2_k127_6988742_22 Protein of unknown function (DUF2842) - - - 0.00000000000003965 76.0
TLS2_k127_6988742_23 - - - - 0.00000001023 66.0
TLS2_k127_6988742_26 - - - - 0.0004857 43.0
TLS2_k127_6988742_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 2.218e-230 726.0
TLS2_k127_6988742_4 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 1.982e-200 630.0
TLS2_k127_6988742_5 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 566.0
TLS2_k127_6988742_6 permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 497.0
TLS2_k127_6988742_7 Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 451.0
TLS2_k127_6988742_8 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 432.0
TLS2_k127_6988742_9 NADH dehydrogenase K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 376.0
TLS2_k127_7016401_0 Domain of unknown function (DUF3520) K07114 - - 3.844e-196 627.0
TLS2_k127_7016401_1 Peptidase family S58 K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007272 489.0
TLS2_k127_7016401_2 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 440.0
TLS2_k127_7016401_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005789 321.0
TLS2_k127_7016401_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000009859 228.0
TLS2_k127_7016401_5 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000005237 126.0
TLS2_k127_7016401_6 Uncharacterized protein conserved in bacteria (DUF2199) - - - 0.000000000000000000000000001504 119.0
TLS2_k127_7016401_7 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000001028 79.0
TLS2_k127_7043371_0 ABC 3 transport family K11605 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 460.0
TLS2_k127_7043371_1 ABC 3 transport family K02075,K11606,K11708,K11709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 436.0
TLS2_k127_7043371_2 Ion channel - - - 0.000000000000000000003088 94.0
TLS2_k127_7063441_0 Dicarboxylate transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 550.0
TLS2_k127_7063441_1 protein conserved in bacteria K09978 - - 0.000000000000000000000000001037 121.0
TLS2_k127_7063441_2 YnbE-like lipoprotein - - - 0.0000000000002119 72.0
TLS2_k127_7083536_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 600.0
TLS2_k127_7083536_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 565.0
TLS2_k127_7083536_10 Transglycosylase associated protein - - - 0.0000000000000000000000000000000000008594 141.0
TLS2_k127_7083536_11 - - - - 0.00000000000000000000000000002465 123.0
TLS2_k127_7083536_12 Transglycosylase associated protein - - - 0.0000000000000000000000000003355 130.0
TLS2_k127_7083536_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 413.0
TLS2_k127_7083536_3 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 284.0
TLS2_k127_7083536_4 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 296.0
TLS2_k127_7083536_5 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000001301 239.0
TLS2_k127_7083536_6 Protein of unknown function (DUF541) K09807 - - 0.00000000000000000000000000000000000000000000000000000000000000001076 233.0
TLS2_k127_7083536_7 Protein of unknown function (DUF1153) - - - 0.000000000000000000000000000000000000000000000000000003349 195.0
TLS2_k127_7083536_8 Disulfide bond formation protein - - - 0.000000000000000000000000000000000000000000003553 172.0
TLS2_k127_7083536_9 - - - - 0.00000000000000000000000000000000000002195 149.0
TLS2_k127_7112508_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 2.054e-234 729.0
TLS2_k127_7112508_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006482 269.0
TLS2_k127_7112508_2 Putative serine dehydratase domain K01753 - 4.3.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000009676 246.0
TLS2_k127_7112508_3 - - - - 0.0000000000000000000000000000000000000001931 156.0
TLS2_k127_7112508_4 - - - - 0.000003854 55.0
TLS2_k127_7235210_0 TonB dependent receptor - - - 0.0 1086.0
TLS2_k127_7235210_1 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0 1007.0
TLS2_k127_7235210_2 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 588.0
TLS2_k127_7235210_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 539.0
TLS2_k127_7235210_4 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 487.0
TLS2_k127_7235210_5 Carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 416.0
TLS2_k127_7235210_6 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000177 289.0
TLS2_k127_7235210_7 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000002648 231.0
TLS2_k127_7235210_8 - - - - 0.00000000000001657 84.0
TLS2_k127_7251874_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 1.337e-286 891.0
TLS2_k127_7251874_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 361.0
TLS2_k127_7251874_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000001508 248.0
TLS2_k127_7251874_3 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000000003266 213.0
TLS2_k127_7251874_4 Protein of unknown function (DUF1465) K13592 - - 0.000000000000000000000000000000000000000005059 161.0
TLS2_k127_7251874_5 Protein of unknown function (DUF465) - - - 0.00000000000000005561 83.0
TLS2_k127_7251874_6 Protein of unknown function (DUF465) - - - 0.0000000001412 63.0
TLS2_k127_7251874_7 Putative bacterial sensory transduction regulator - - - 0.00000000206 66.0
TLS2_k127_7251874_8 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000001706 62.0
TLS2_k127_7274143_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 4.083e-220 689.0
TLS2_k127_7274143_1 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 432.0
TLS2_k127_7274143_2 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 345.0
TLS2_k127_7274143_3 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 308.0
TLS2_k127_7274143_4 PFAM Ion transport K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 299.0
TLS2_k127_7274143_5 DedA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003082 271.0
TLS2_k127_7274143_6 - - - - 0.0000000000000000000000000000000000000000000001824 186.0
TLS2_k127_7274143_7 Outer membrane protein beta-barrel domain K16079 - - 0.0000000000000000000000000000000000000128 152.0
TLS2_k127_7274143_8 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000001623 98.0
TLS2_k127_7274143_9 Glutathione S-transferase K00799 - 2.5.1.18 0.00000006569 55.0
TLS2_k127_7331642_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 9.27e-245 762.0
TLS2_k127_7331642_1 NAD(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 301.0
TLS2_k127_7331642_2 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.00000000000000000000000000000000000000000002657 162.0
TLS2_k127_7331642_3 - - - - 0.000000000000007241 79.0
TLS2_k127_7341946_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 7.579e-198 631.0
TLS2_k127_7341946_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006684 572.0
TLS2_k127_7341946_2 Cell division protein FtsQ K03589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006121 296.0
TLS2_k127_7341946_3 Cell wall formation K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000003112 173.0
TLS2_k127_7341946_4 Tetratricopeptide repeat - - - 0.000801 49.0
TLS2_k127_7409398_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1106.0
TLS2_k127_7409398_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 2.136e-236 749.0
TLS2_k127_7409398_10 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 425.0
TLS2_k127_7409398_11 Cell wall formation K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 386.0
TLS2_k127_7409398_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002551 254.0
TLS2_k127_7409398_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000003128 222.0
TLS2_k127_7409398_14 Glyoxalase-like domain K04750 - - 0.0000000000000000000000000000000000000000000000000000000000000212 217.0
TLS2_k127_7409398_15 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000009524 138.0
TLS2_k127_7409398_16 - - - - 0.0000000000000000000000001101 111.0
TLS2_k127_7409398_17 - - - - 0.0000000000000000000000001197 115.0
TLS2_k127_7409398_19 2 iron, 2 sulfur cluster binding K02192 GO:0003674,GO:0005488,GO:0048037,GO:0051536,GO:0051537,GO:0051540 - 0.0002177 44.0
TLS2_k127_7409398_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 7.439e-212 674.0
TLS2_k127_7409398_3 Cell division protein FtsI penicillin-binding protein K03587 - 3.4.16.4 3.989e-196 640.0
TLS2_k127_7409398_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 603.0
TLS2_k127_7409398_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008201 583.0
TLS2_k127_7409398_6 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 556.0
TLS2_k127_7409398_7 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 545.0
TLS2_k127_7409398_8 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 530.0
TLS2_k127_7409398_9 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 451.0
TLS2_k127_755599_0 Protein of unknown function (DUF938) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001376 262.0
TLS2_k127_755599_1 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000000000000000000000001231 219.0
TLS2_k127_755599_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000195 115.0
TLS2_k127_755599_3 - - - - 0.00002612 55.0
TLS2_k127_76266_0 ATP-dependent helicase K03579 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 602.0
TLS2_k127_76266_1 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008335 411.0
TLS2_k127_76266_2 response to hydrogen peroxide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 316.0
TLS2_k127_76266_3 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009026 248.0
TLS2_k127_76266_4 Protein of unknown function (DUF541) K09807 - - 0.0000000000000000000000000000000000000000000000000000000000000000008192 242.0
TLS2_k127_76266_5 - - - - 0.00000000000000000000000002297 112.0
TLS2_k127_76266_6 heme binding - - - 0.0000000000001522 72.0
TLS2_k127_76445_0 DJ-1/PfpI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 324.0
TLS2_k127_76445_1 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003469 271.0
TLS2_k127_79085_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 505.0
TLS2_k127_79085_1 Male sterility protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003546 426.0
TLS2_k127_79085_10 Domain of unknown function (DUF1476) - - - 0.000000000000000000000000000000000000001433 149.0
TLS2_k127_79085_11 Belongs to the BolA IbaG family - - - 0.000000000000000000000000000003389 123.0
TLS2_k127_79085_2 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 391.0
TLS2_k127_79085_3 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 390.0
TLS2_k127_79085_4 HAD superfamily, subfamily IIIB (Acid phosphatase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 299.0
TLS2_k127_79085_5 Antirepressor regulating drug resistance - - - 0.00000000000000000000000000000000000000000000000000000001129 213.0
TLS2_k127_79085_6 Protein of unknown function (DUF4230) - - - 0.00000000000000000000000000000000000000000000000000007459 198.0
TLS2_k127_79085_7 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000000002545 183.0
TLS2_k127_79085_8 Penicillinase repressor - - - 0.00000000000000000000000000000000000000000000000003051 182.0
TLS2_k127_79085_9 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000001926 173.0
TLS2_k127_848820_0 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005304 458.0
TLS2_k127_848820_1 FAD-NAD(P)-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000717 389.0
TLS2_k127_848820_10 - - - - 0.00000000000000000000004155 114.0
TLS2_k127_848820_11 - - - - 0.00000001069 67.0
TLS2_k127_848820_2 cation diffusion facilitator family transporter K16264 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 380.0
TLS2_k127_848820_3 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003201 339.0
TLS2_k127_848820_4 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 295.0
TLS2_k127_848820_5 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000001077 278.0
TLS2_k127_848820_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000002318 214.0
TLS2_k127_848820_7 Spermidine synthase - - - 0.0000000000000000000000000000000000000000000000000000000005812 208.0
TLS2_k127_848820_8 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000001503 205.0
TLS2_k127_848820_9 Nickel/cobalt transporter regulator - - - 0.00000000000000000000000000000000000001508 155.0
TLS2_k127_973037_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000588 236.0
TLS2_k127_987171_0 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001831 277.0
TLS2_k127_987171_1 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01469 - 3.5.2.9 0.00003745 46.0