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Overview

ID MAG03986
Name TLS2_bin.17
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Geminicoccales
Family Geminicoccaceae
Genus
Species
Assembly information
Completeness (%) 89.49
Contamination (%) 5.06
GC content (%) 71.0
N50 (bp) 10,277
Genome size (bp) 5,117,049

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes4983

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1000028_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K12661 - 4.2.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 541.0
TLS2_k127_1000028_1 Glucose sorbosone - - - 0.000000000000000000000000002895 119.0
TLS2_k127_1000028_2 EamA-like transporter family - - - 0.000000000000000000001314 100.0
TLS2_k127_1000028_3 PFAM Plasmid stabilisation system protein - - - 0.00002032 49.0
TLS2_k127_1000028_4 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0001206 52.0
TLS2_k127_1002194_0 HemY protein N-terminus K02498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 358.0
TLS2_k127_1002194_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005245 318.0
TLS2_k127_1002194_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 316.0
TLS2_k127_1002194_3 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000001502 184.0
TLS2_k127_1002194_4 nuclear chromosome segregation - - - 0.0000000000000007581 92.0
TLS2_k127_1004624_0 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003735 376.0
TLS2_k127_1004624_1 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000005971 240.0
TLS2_k127_1004624_2 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000001238 223.0
TLS2_k127_1009615_0 Maltogenic Amylase, C-terminal domain K05343 - 3.2.1.1,5.4.99.16 0.0 1513.0
TLS2_k127_1009615_1 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB K16147 - 2.4.99.16 0.0 1451.0
TLS2_k127_1009615_2 Belongs to the BCCT transporter (TC 2.A.15) family K02168 - - 1.45e-202 644.0
TLS2_k127_1009615_3 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001643 384.0
TLS2_k127_1009615_4 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000571 254.0
TLS2_k127_1009615_5 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000001252 177.0
TLS2_k127_1009615_6 XdhC and CoxI family - - - 0.000000000000000000000000000000000000003512 152.0
TLS2_k127_1009615_7 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.000000000000000000000000000000000005705 141.0
TLS2_k127_1009615_8 Pfam:DUF461 K09796 - - 0.0000000000000000000000000000003122 129.0
TLS2_k127_1012465_0 Acetamidase/Formamidase family K01455 - 3.5.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 542.0
TLS2_k127_1012465_1 PFAM Transposase, IS4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004581 374.0
TLS2_k127_1012465_2 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004617 328.0
TLS2_k127_1012465_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000008631 235.0
TLS2_k127_1012465_4 - - - - 0.0000000000000000000000000000000001159 140.0
TLS2_k127_1012465_5 transposase activity - - - 0.000000000000000000000000000001061 126.0
TLS2_k127_1015385_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000007408 187.0
TLS2_k127_1015385_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000009451 183.0
TLS2_k127_1015385_2 GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000001046 166.0
TLS2_k127_1015385_3 glycosyl transferase group 1 - - - 0.000000000000000000000000000000002209 146.0
TLS2_k127_1017368_0 Bacterial extracellular solute-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 444.0
TLS2_k127_1017368_1 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 420.0
TLS2_k127_1017368_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 402.0
TLS2_k127_1017368_3 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004551 272.0
TLS2_k127_1017368_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00015 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000008069 201.0
TLS2_k127_1019849_0 Iron deficiency-induced protein A K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 452.0
TLS2_k127_1019849_1 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 449.0
TLS2_k127_1023282_0 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 438.0
TLS2_k127_1023282_1 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001074 284.0
TLS2_k127_1023282_2 Flagellar motor component K02556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005374 263.0
TLS2_k127_1023282_3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000001739 251.0
TLS2_k127_1023282_4 PFAM OmpA MotB domain protein K02557 - - 0.00000000000000000000000000000000000000000000001455 182.0
TLS2_k127_1023282_5 - - - - 0.00000000000000000000000000000009281 130.0
TLS2_k127_1023721_0 Sodium:sulfate symporter transmembrane region K14445 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007651 393.0
TLS2_k127_1023721_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000003625 188.0
TLS2_k127_1029305_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 3.931e-226 716.0
TLS2_k127_1029305_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 468.0
TLS2_k127_1029305_2 ATPase involved in DNA repair - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 463.0
TLS2_k127_1029305_3 COG0420 DNA repair exonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 327.0
TLS2_k127_1029305_4 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003095 274.0
TLS2_k127_1029305_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000002079 209.0
TLS2_k127_1029305_6 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.00000000000000001585 94.0
TLS2_k127_1029370_0 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 472.0
TLS2_k127_1029370_1 Surface antigen K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006995 451.0
TLS2_k127_1029370_10 COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0000000000000000000000000008899 123.0
TLS2_k127_1029370_11 Protein required for attachment to host cells - - - 0.000000000000000000000000001834 116.0
TLS2_k127_1029370_2 Major Facilitator Superfamily K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 440.0
TLS2_k127_1029370_3 Male sterility protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004351 426.0
TLS2_k127_1029370_4 PhoPQ-activated pathogenicity-related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 337.0
TLS2_k127_1029370_5 Putative beta-barrel porin 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 304.0
TLS2_k127_1029370_6 Calcineurin-like phosphoesterase K07313 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 287.0
TLS2_k127_1029370_7 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000005124 207.0
TLS2_k127_1029370_8 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000004272 186.0
TLS2_k127_1029370_9 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000401 153.0
TLS2_k127_1030460_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.652e-295 918.0
TLS2_k127_1030460_1 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 309.0
TLS2_k127_1030460_2 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006105 293.0
TLS2_k127_1030460_3 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.000000000000000000000000001689 116.0
TLS2_k127_1030460_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000001973 80.0
TLS2_k127_1030460_5 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.0000000000000003905 90.0
TLS2_k127_1035624_0 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 416.0
TLS2_k127_1035624_1 Enoyl-(Acyl carrier protein) reductase K00034 - 1.1.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007041 373.0
TLS2_k127_1035624_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 358.0
TLS2_k127_1035624_3 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006764 346.0
TLS2_k127_1035624_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000001252 138.0
TLS2_k127_1035624_5 FR47-like protein - - - 0.00000000000000000000000000000007589 132.0
TLS2_k127_1039408_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.734e-227 715.0
TLS2_k127_1039408_1 Nitronate monooxygenase K00459 - 1.13.12.16 3.607e-220 692.0
TLS2_k127_1039408_2 Belongs to the Fur family K09826 - - 0.000000000000000000000000000000000000000000001335 168.0
TLS2_k127_1039579_0 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 389.0
TLS2_k127_1039579_1 2Fe-2S iron-sulfur cluster binding domain K22086 - 1.5.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 327.0
TLS2_k127_1039579_2 Sarcosine oxidase, delta subunit K00304,K22085 - 1.5.3.1,1.5.99.5 0.00000000000000000000000678 113.0
TLS2_k127_1040745_0 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000743 306.0
TLS2_k127_1040745_1 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.0000000000000000000000000000000000000000001726 167.0
TLS2_k127_1040745_2 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K02051 - - 0.00000006365 64.0
TLS2_k127_1042772_0 peptidase - - - 1.882e-227 721.0
TLS2_k127_1042772_1 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 389.0
TLS2_k127_1042772_2 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 384.0
TLS2_k127_1042772_3 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002362 239.0
TLS2_k127_1042772_4 PFAM Transposase, IS4-like - - - 0.0000000000000000000000000000000000000008595 152.0
TLS2_k127_1042772_5 Protein of unknown function (DUF971) - - - 0.000000000000000000000003066 102.0
TLS2_k127_1046801_0 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000712 391.0
TLS2_k127_1046801_1 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000008089 209.0
TLS2_k127_1046801_2 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000007415 154.0
TLS2_k127_1049015_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 9.055e-214 676.0
TLS2_k127_1049015_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 442.0
TLS2_k127_1049015_2 TIGRFAM glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002071 280.0
TLS2_k127_1049015_3 protein conserved in bacteria K09798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001187 268.0
TLS2_k127_1049015_4 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000001196 124.0
TLS2_k127_1049061_0 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 448.0
TLS2_k127_1049061_1 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003095 283.0
TLS2_k127_1049061_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 0.00000000000000000000000000000000000018 143.0
TLS2_k127_1049061_3 Laminin G domain - - - 0.00000000000000000000000000000001592 146.0
TLS2_k127_1049061_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000002628 105.0
TLS2_k127_1049061_5 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.00000000000000000001945 107.0
TLS2_k127_1049061_6 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.0000000001559 74.0
TLS2_k127_105487_0 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 587.0
TLS2_k127_105487_1 cell redox homeostasis K00383 - 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 495.0
TLS2_k127_105487_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 343.0
TLS2_k127_1054877_0 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 509.0
TLS2_k127_1054877_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000771 451.0
TLS2_k127_1054877_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000001825 193.0
TLS2_k127_1054877_3 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 - 3.4.19.3 0.0000000000000000000000000000000000000000000000000007657 193.0
TLS2_k127_1054877_4 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000001555 164.0
TLS2_k127_1059747_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 455.0
TLS2_k127_1059747_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 427.0
TLS2_k127_1059747_2 Belongs to the D-alanine--D-alanine ligase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 395.0
TLS2_k127_1059747_3 Putative esterase K07214 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 302.0
TLS2_k127_1059747_4 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000000000000000000000000000000000000000001111 234.0
TLS2_k127_1059747_5 Putative esterase - - - 0.00000000003232 72.0
TLS2_k127_1060344_0 Exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 440.0
TLS2_k127_1060344_1 Type II secretion system (T2SS), protein G K02456 - - 0.000000000000000000000000000000000000000000000001613 177.0
TLS2_k127_1060344_2 Pfam:N_methyl_2 K02459 - - 0.000000000000000000000003917 111.0
TLS2_k127_1060344_3 General secretion pathway protein H K02457 - - 0.00000000000000000001236 98.0
TLS2_k127_1060344_4 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.000000000000000001491 93.0
TLS2_k127_1060344_5 General secretion pathway protein K02458 - - 0.0000000006782 65.0
TLS2_k127_1063976_0 PQQ-like domain K00114 - 1.1.2.8 1.035e-248 771.0
TLS2_k127_1063976_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 612.0
TLS2_k127_1063976_10 Pilus assembly protein K02282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004726 288.0
TLS2_k127_1063976_11 Bacterial periplasmic substrate-binding proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001593 271.0
TLS2_k127_1063976_12 Type II secretion system (T2SS), protein F K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000003897 261.0
TLS2_k127_1063976_13 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.000000000000000000000000000000000000000000000000000000000009671 217.0
TLS2_k127_1063976_14 Rhodanese-like domain - - - 0.000000000000000000000000000000000000000000000009125 189.0
TLS2_k127_1063976_15 Sulfotransferase family - - - 0.00000000000000000000000000000000000000000000002477 182.0
TLS2_k127_1063976_16 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000001695 155.0
TLS2_k127_1063976_17 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000005186 144.0
TLS2_k127_1063976_18 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000001646 141.0
TLS2_k127_1063976_19 NAD(P) transhydrogenase subunit alpha K00324 GO:0008150,GO:0008152,GO:0055114 1.6.1.2 0.00000000000000000000000000001881 132.0
TLS2_k127_1063976_2 Type II/IV secretion system protein K02283,K20527 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 599.0
TLS2_k127_1063976_20 Histidine kinase-like ATPase domain - - - 0.000000000000000000000001232 115.0
TLS2_k127_1063976_21 Pilus biogenesis CpaD protein (pilus_cpaD) K02281 - - 0.000000000000000000000006851 110.0
TLS2_k127_1063976_22 Type IV leader peptidase family - - - 0.000000000000000000006195 100.0
TLS2_k127_1063976_3 Alanine dehydrogenase/PNT, C-terminal domain K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 447.0
TLS2_k127_1063976_4 Pilus formation protein N terminal region K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 416.0
TLS2_k127_1063976_5 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 329.0
TLS2_k127_1063976_6 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003802 329.0
TLS2_k127_1063976_7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 318.0
TLS2_k127_1063976_8 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 308.0
TLS2_k127_1063976_9 type II secretion system K12511 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004702 286.0
TLS2_k127_1068848_0 Chalcone and stilbene synthases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 406.0
TLS2_k127_1068848_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000004233 196.0
TLS2_k127_1068848_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000001446 60.0
TLS2_k127_1075070_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.782e-290 904.0
TLS2_k127_1075070_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009664 468.0
TLS2_k127_1075070_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 391.0
TLS2_k127_1078415_0 PFAM transposase IS116 IS110 IS902 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 473.0
TLS2_k127_1078415_1 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004549 272.0
TLS2_k127_1078415_2 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000000000000000000000000000000000006657 182.0
TLS2_k127_1078415_3 Transposase - - - 0.00000000000000000000000000001483 121.0
TLS2_k127_108085_0 Bacteriophage head to tail connecting protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 569.0
TLS2_k127_108085_1 beta-keto acid cleavage enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001466 268.0
TLS2_k127_108085_2 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000004076 223.0
TLS2_k127_108085_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000006092 241.0
TLS2_k127_108085_4 - - - - 0.000000000000000000003181 99.0
TLS2_k127_108085_5 - - - - 0.0000000000006159 76.0
TLS2_k127_108085_6 - - - - 0.0000105 52.0
TLS2_k127_1096880_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1405.0
TLS2_k127_1096880_1 RES - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 290.0
TLS2_k127_1096880_2 carbon monoxide dehydrogenase K09386 - - 0.000000000000000000000000000000000000000000000000000000000000009628 222.0
TLS2_k127_1096880_3 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000000000000000000000007848 189.0
TLS2_k127_1096880_4 Helix-turn-helix XRE-family like proteins K21498 - - 0.00000000000000000000000000000000000000000138 158.0
TLS2_k127_1096880_5 Protein of unknown function (DUF2384) - - - 0.000000000000000000000000000000000001464 143.0
TLS2_k127_1103043_0 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 464.0
TLS2_k127_1103043_1 Aldo/keto reductase family K06222 - 1.1.1.346 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 293.0
TLS2_k127_1103043_2 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000000000000001987 212.0
TLS2_k127_1103043_3 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.0000000000000001436 80.0
TLS2_k127_1104941_0 carbamoyl transferase, NodU family K00612 - - 8.123e-234 736.0
TLS2_k127_1104941_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 476.0
TLS2_k127_1104941_10 Ferredoxin K04755 - - 0.0000000000000000000000000000003545 127.0
TLS2_k127_1104941_11 Putative beta-barrel porin 2 - - - 0.0000000000000001456 93.0
TLS2_k127_1104941_12 polysaccharide biosynthetic process - - - 0.000000005972 68.0
TLS2_k127_1104941_13 Pectate lyase superfamily protein - - - 0.00003767 57.0
TLS2_k127_1104941_2 PFAM lipopolysaccharide biosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 389.0
TLS2_k127_1104941_3 eight transmembrane protein EpsH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 382.0
TLS2_k127_1104941_4 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 323.0
TLS2_k127_1104941_5 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 322.0
TLS2_k127_1104941_6 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 302.0
TLS2_k127_1104941_7 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000001407 186.0
TLS2_k127_1104941_8 AAA domain - - - 0.0000000000000000000000000000000000000000000001256 182.0
TLS2_k127_1104941_9 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000003232 141.0
TLS2_k127_1114747_0 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 6.658e-266 829.0
TLS2_k127_1114747_1 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 573.0
TLS2_k127_1114747_10 oxygen carrier activity K07216 - - 0.00000000000000000000001765 114.0
TLS2_k127_1114747_11 Glycosyl transferase family, a/b domain - - - 0.0000000000000000002438 90.0
TLS2_k127_1114747_12 - - - - 0.0000000000003476 71.0
TLS2_k127_1114747_2 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003836 542.0
TLS2_k127_1114747_3 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 513.0
TLS2_k127_1114747_4 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 319.0
TLS2_k127_1114747_5 cytochrome c oxidase (Subunit II) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003543 276.0
TLS2_k127_1114747_6 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000161 237.0
TLS2_k127_1114747_7 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000192 215.0
TLS2_k127_1114747_8 Cupin domain - - - 0.00000000000000000000000000000000000002287 149.0
TLS2_k127_1114747_9 - - - - 0.000000000000000000000000000284 124.0
TLS2_k127_1115196_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 2.679e-257 812.0
TLS2_k127_1115196_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 372.0
TLS2_k127_1115196_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 346.0
TLS2_k127_1115196_3 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004708 319.0
TLS2_k127_1115196_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 311.0
TLS2_k127_1115196_5 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000132 286.0
TLS2_k127_1115196_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000002646 244.0
TLS2_k127_1115196_7 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000538 154.0
TLS2_k127_1125071_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007676 414.0
TLS2_k127_1125071_1 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 357.0
TLS2_k127_1128841_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 8.129e-261 815.0
TLS2_k127_1128841_1 Glucoamylase and related glycosyl hydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 500.0
TLS2_k127_1128841_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000007686 159.0
TLS2_k127_1129190_0 Histidine kinase-like ATPases - - - 4.519e-202 655.0
TLS2_k127_1129190_1 COG1653 ABC-type sugar transport system, periplasmic component K17315 - - 2.115e-194 614.0
TLS2_k127_1129190_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 495.0
TLS2_k127_1129190_3 cheY-homologous receiver domain K11443 - - 0.00000000000000000000000000000000000000000000005902 189.0
TLS2_k127_1130093_0 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 417.0
TLS2_k127_1130093_1 ABC transporter (Periplasmic binding protein) K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 387.0
TLS2_k127_1130093_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000001675 121.0
TLS2_k127_115044_0 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 510.0
TLS2_k127_115044_1 N-terminal TM domain of oligopeptide transport permease C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 422.0
TLS2_k127_115044_2 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000009878 243.0
TLS2_k127_115044_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000001565 132.0
TLS2_k127_1157381_0 PQQ-like domain K00114 - 1.1.2.8 1.026e-263 824.0
TLS2_k127_1157381_1 Zinc-uptake complex component A periplasmic K11707 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 362.0
TLS2_k127_1157381_2 ATPases associated with a variety of cellular activities K11607,K11710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 352.0
TLS2_k127_1157381_3 ABC 3 transport family K11708 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000018 291.0
TLS2_k127_115973_0 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 304.0
TLS2_k127_115973_1 Protein of unknown function (DUF3750) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000163 282.0
TLS2_k127_115973_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.00000000000000000008944 89.0
TLS2_k127_1178463_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 3.612e-206 694.0
TLS2_k127_1178463_1 ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 330.0
TLS2_k127_1178463_2 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.00000000000000000000000000000000000000000000000000000000000002219 220.0
TLS2_k127_1182331_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 1.924e-258 840.0
TLS2_k127_1182331_1 Carbohydrate ABC transporter substrate-binding protein, CUT1 family K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 585.0
TLS2_k127_1182331_10 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 315.0
TLS2_k127_1182331_11 ABC-type sugar transport system, permease component K02026,K17323 - - 0.00000000000000000000000000000000000000000005152 177.0
TLS2_k127_1182331_12 Essential cell division protein K03589 - - 0.000000000000000000000000000000000000000006247 173.0
TLS2_k127_1182331_13 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.00000000000000000000000001371 114.0
TLS2_k127_1182331_14 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000005012 106.0
TLS2_k127_1182331_15 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000004431 99.0
TLS2_k127_1182331_17 - - - - 0.00000000003129 70.0
TLS2_k127_1182331_18 Protein of unknown function (DUF3018) - - - 0.0000000001017 64.0
TLS2_k127_1182331_2 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009108 535.0
TLS2_k127_1182331_3 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001982 535.0
TLS2_k127_1182331_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 469.0
TLS2_k127_1182331_5 Carbohydrate ABC transporter membrane protein 1, CUT1 family K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 405.0
TLS2_k127_1182331_6 Belongs to the D-alanine--D-alanine ligase family K00075,K01921 - 1.3.1.98,6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008275 372.0
TLS2_k127_1182331_7 HpcH/HpaI aldolase/citrate lyase family K01630 - 4.1.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000949 351.0
TLS2_k127_1182331_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 347.0
TLS2_k127_1182331_9 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 348.0
TLS2_k127_1183293_0 GTP cyclohydrolase N terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 595.0
TLS2_k127_1183293_1 Protein of unknown function (DUF1688) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 454.0
TLS2_k127_1183293_2 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase K16856 - 4.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000662 391.0
TLS2_k127_1183293_3 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000001757 138.0
TLS2_k127_1183293_4 MULE transposase domain - - - 0.0000000000004358 72.0
TLS2_k127_1193276_0 helicase activity K03466,K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 450.0
TLS2_k127_1193276_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002228 276.0
TLS2_k127_1193276_2 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000585 199.0
TLS2_k127_1193276_3 E-Z type HEAT repeats - - - 0.00000002358 58.0
TLS2_k127_1197411_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 334.0
TLS2_k127_1197411_1 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 310.0
TLS2_k127_119814_0 Prokaryotic cytochrome b561 K00127 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 409.0
TLS2_k127_119814_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008371 381.0
TLS2_k127_119814_2 WD domain, G-beta repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 343.0
TLS2_k127_119814_3 PAP2 superfamily - - - 0.00000000000000000000000000000000000006492 164.0
TLS2_k127_119814_4 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000016 86.0
TLS2_k127_1218379_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000761 490.0
TLS2_k127_1218379_1 Phage plasmid primase P4 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003153 245.0
TLS2_k127_1218379_2 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000001043 59.0
TLS2_k127_1225192_0 Tripartite tricarboxylate transporter TctA family K07793 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 372.0
TLS2_k127_1225192_1 phosphate regulon transcriptional regulatory protein PhoB K07657,K07659,K18144 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
TLS2_k127_1225192_2 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007952 274.0
TLS2_k127_1225192_3 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000000000000000000000000000000000000000000322 173.0
TLS2_k127_1225192_4 Domain of unknown function (DUF1127) - - - 0.0005322 47.0
TLS2_k127_1228391_0 Enoyl-(Acyl carrier protein) reductase K22185 - 1.1.1.175 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 363.0
TLS2_k127_1228391_1 Acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008034 278.0
TLS2_k127_1228391_2 Domain of unknown function DUF29 - - - 0.000000000000000000000000000004675 124.0
TLS2_k127_1228391_3 Domain of unknown function DUF29 - - - 0.0000000000000000000000000001626 120.0
TLS2_k127_1228391_4 Domain of unknown function DUF29 - - - 0.000000000000000000000000003056 119.0
TLS2_k127_1228391_5 Cell division protein K09811 - - 0.0000000000001102 75.0
TLS2_k127_1228391_6 Protein of unknown function DUF86 - - - 0.00001221 48.0
TLS2_k127_123205_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 421.0
TLS2_k127_123205_1 tRNA synthetases class I (E and Q), catalytic domain K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008653 376.0
TLS2_k127_123205_2 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009854 340.0
TLS2_k127_123205_3 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000942 263.0
TLS2_k127_123205_4 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000001568 148.0
TLS2_k127_123205_5 PFAM Transglycosylase-associated protein - - - 0.000000000000004677 78.0
TLS2_k127_1235216_0 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 1.186e-203 646.0
TLS2_k127_1235216_1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 594.0
TLS2_k127_1235216_10 Dodecin K09165 - - 0.00000000000000000000000002812 111.0
TLS2_k127_1235216_11 - - - - 0.0000000000000000000000002845 110.0
TLS2_k127_1235216_12 cheY-homologous receiver domain - - - 0.000000000000000000000002603 109.0
TLS2_k127_1235216_13 PRC-barrel domain - - - 0.00000000572 69.0
TLS2_k127_1235216_14 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000002612 66.0
TLS2_k127_1235216_15 PRC-barrel domain - - - 0.00000004507 66.0
TLS2_k127_1235216_2 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 559.0
TLS2_k127_1235216_3 COG1957 Inosine-uridine nucleoside N-ribohydrolase K01239 - 3.2.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 397.0
TLS2_k127_1235216_4 Sugar (and other) transporter K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 338.0
TLS2_k127_1235216_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007989 287.0
TLS2_k127_1235216_6 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000001079 272.0
TLS2_k127_1235216_7 HWE histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001659 274.0
TLS2_k127_1235216_8 Peptidase_C39 like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009078 253.0
TLS2_k127_1235216_9 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000000000000000000000000000000000000001714 191.0
TLS2_k127_1240749_0 Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism K02567 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016661,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 - 0.0 1367.0
TLS2_k127_1240749_1 Type II/IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 580.0
TLS2_k127_1240749_10 Periplasmic nitrate reductase protein NapE K02571 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000001108 57.0
TLS2_k127_1240749_2 TIGRFAM periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC NirT family K02569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006868 334.0
TLS2_k127_1240749_3 COG4965 Flp pilus assembly protein TadB K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007267 266.0
TLS2_k127_1240749_4 type II secretion system protein K12511 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002786 265.0
TLS2_k127_1240749_5 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 - - 0.00000000000000000000000000000000000000000000002466 186.0
TLS2_k127_1240749_6 Cellulose biosynthesis protein BcsQ K02282 - - 0.0000000000000000000000000000000000000000000004656 181.0
TLS2_k127_1240749_7 Tetratricopeptide repeat - - - 0.0000000000000000000000000003833 126.0
TLS2_k127_1240749_8 peptidyl-tyrosine sulfation - - - 0.000000000000000000000003046 114.0
TLS2_k127_1240749_9 NapD protein K02570 - - 0.000000000006612 71.0
TLS2_k127_1249024_0 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 7.199e-199 631.0
TLS2_k127_1249024_1 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000621 452.0
TLS2_k127_1249024_2 Belongs to the thiolase family K00632 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000004968 215.0
TLS2_k127_1249024_3 Sulfatase-modifying factor enzyme 1 - - - 0.00005159 46.0
TLS2_k127_1257039_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 565.0
TLS2_k127_1257039_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 448.0
TLS2_k127_1257039_2 membrane protein, required for colicin V production K03558 - - 0.00000000000000000000002406 116.0
TLS2_k127_1267366_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 501.0
TLS2_k127_1267366_1 Acetolactate synthase K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 396.0
TLS2_k127_1267366_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 295.0
TLS2_k127_1267366_3 haloacid dehalogenase-like hydrolase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005158 275.0
TLS2_k127_1273883_0 Belongs to the mandelate racemase muconate lactonizing enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 521.0
TLS2_k127_1273883_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007469 447.0
TLS2_k127_1273883_10 Has an organic peroxide-dependent peroxidase activity K03781 - 1.11.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000255 272.0
TLS2_k127_1273883_11 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000002609 262.0
TLS2_k127_1273883_12 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000000000000000000000000000000000000000000008528 237.0
TLS2_k127_1273883_13 Protein of unknown function (DUF2384) - - - 0.00000000000000000000000000000000000000000000000000000001974 199.0
TLS2_k127_1273883_14 Esterase-like activity of phytase - - - 0.000000000000000000000000000000000000000000000008304 186.0
TLS2_k127_1273883_15 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000001905 171.0
TLS2_k127_1273883_16 Putative sugar-binding N-terminal domain K22129 - 2.7.1.219,2.7.1.220 0.0000000000000000000000000000000003721 141.0
TLS2_k127_1273883_17 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000000000000002828 126.0
TLS2_k127_1273883_18 YGGT family K02221 - - 0.00000000000000000000000000001731 122.0
TLS2_k127_1273883_19 plasmid stabilization K19092 - - 0.00000000000000000000008857 106.0
TLS2_k127_1273883_2 Belongs to the LDH2 MDH2 oxidoreductase family K00073 - 1.1.1.350 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003322 395.0
TLS2_k127_1273883_20 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.000000000004366 74.0
TLS2_k127_1273883_21 Belongs to the UPF0235 family K09131 - - 0.0000000003617 65.0
TLS2_k127_1273883_22 addiction module antidote protein K07746 - - 0.00000000127 63.0
TLS2_k127_1273883_3 Pyridoxal phosphate biosynthetic protein PdxA K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 394.0
TLS2_k127_1273883_4 Iron-containing alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 386.0
TLS2_k127_1273883_5 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005448 374.0
TLS2_k127_1273883_6 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 334.0
TLS2_k127_1273883_7 RES domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 314.0
TLS2_k127_1273883_8 Belongs to the BI1 family K06890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 287.0
TLS2_k127_1273883_9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005894 288.0
TLS2_k127_1274241_0 Malate synthase K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 376.0
TLS2_k127_1274241_1 Transposase domain (DUF772) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001076 267.0
TLS2_k127_1274241_2 Transposase domain (DUF772) - - - 0.000000000000000000000000000000000000000000000000000000000000000000003347 249.0
TLS2_k127_1275267_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 448.0
TLS2_k127_1275267_1 SMART Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 445.0
TLS2_k127_1275267_2 FecR protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007573 415.0
TLS2_k127_1275267_3 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 391.0
TLS2_k127_1275267_4 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 300.0
TLS2_k127_1275267_5 depolymerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001006 273.0
TLS2_k127_1275267_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000004502 218.0
TLS2_k127_1275267_7 toxin-antitoxin pair type II binding K19156 - - 0.0002247 54.0
TLS2_k127_1277845_0 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 498.0
TLS2_k127_1277845_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 492.0
TLS2_k127_1277845_10 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000001015 156.0
TLS2_k127_1277845_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 478.0
TLS2_k127_1277845_3 TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007132 449.0
TLS2_k127_1277845_4 GtrA-like protein K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005817 419.0
TLS2_k127_1277845_5 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000001115 265.0
TLS2_k127_1277845_6 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004997 249.0
TLS2_k127_1277845_7 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000002302 216.0
TLS2_k127_1277845_8 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000005366 210.0
TLS2_k127_1277845_9 COG0262 Dihydrofolate reductase - - - 0.000000000000000000000000000000000000000001706 164.0
TLS2_k127_130920_0 56kDa selenium binding protein (SBP56) K17285 - - 9.801e-271 837.0
TLS2_k127_130920_1 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 537.0
TLS2_k127_130920_2 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 306.0
TLS2_k127_130920_3 Adenylate guanylate cyclase with Chase sensor K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008079 317.0
TLS2_k127_130920_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000008922 238.0
TLS2_k127_130920_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000001528 175.0
TLS2_k127_1310845_0 Cache domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 359.0
TLS2_k127_1310845_1 xanthine dehydrogenase activity K03520 - 1.2.5.3 0.00000000000000000005189 91.0
TLS2_k127_1314682_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 1.5e-323 1004.0
TLS2_k127_1314682_1 N-terminal domain of (some) glycogen debranching enzymes - - - 1.983e-227 726.0
TLS2_k127_1314682_10 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.00000000000000000000000000000000009519 135.0
TLS2_k127_1314682_11 - - - - 0.0000000000000000000000000000002881 138.0
TLS2_k127_1314682_12 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000000000000000000000008253 134.0
TLS2_k127_1314682_13 Succinate dehydrogenase, hydrophobic anchor subunit K00242 - - 0.000000000000000000000000005495 129.0
TLS2_k127_1314682_14 Transcriptional regulator - - - 0.000000000000000008304 86.0
TLS2_k127_1314682_15 - - - - 0.000000001566 64.0
TLS2_k127_1314682_2 Zn-dependent proteases and their inactivated homologs K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 505.0
TLS2_k127_1314682_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 483.0
TLS2_k127_1314682_4 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 465.0
TLS2_k127_1314682_5 transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 354.0
TLS2_k127_1314682_6 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008716 275.0
TLS2_k127_1314682_7 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000856 271.0
TLS2_k127_1314682_8 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000001522 234.0
TLS2_k127_1314682_9 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.000000000000000000000000000000000000000001518 159.0
TLS2_k127_1318359_0 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1622.0
TLS2_k127_1318359_1 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 558.0
TLS2_k127_1318359_2 4Fe-4S dicluster domain K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 410.0
TLS2_k127_1318359_3 Nitrate reductase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000002404 230.0
TLS2_k127_1318359_4 - - - - 0.00000000000000000000000000000000000000000000000000000004413 207.0
TLS2_k127_1318359_5 HicB family - - - 0.00000000000000000000000009797 110.0
TLS2_k127_1318359_6 TIGRFAM formate dehydrogenase region TAT target - - - 0.000000002311 61.0
TLS2_k127_1337991_0 ABC transporter transmembrane region K02021 - - 1.12e-282 893.0
TLS2_k127_1337991_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 7.799e-221 697.0
TLS2_k127_1337991_10 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 354.0
TLS2_k127_1337991_11 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 335.0
TLS2_k127_1337991_12 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 298.0
TLS2_k127_1337991_13 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000001461 261.0
TLS2_k127_1337991_14 Aldo Keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000009195 239.0
TLS2_k127_1337991_15 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000000000000004617 230.0
TLS2_k127_1337991_16 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000001614 213.0
TLS2_k127_1337991_17 Protein of unknown function (DUF1538) - - - 0.0000000000000000000000000000000000000000000000000000002303 206.0
TLS2_k127_1337991_18 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000003208 200.0
TLS2_k127_1337991_19 protein methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000008055 206.0
TLS2_k127_1337991_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000662 492.0
TLS2_k127_1337991_20 Pkd domain containing protein - - - 0.0000000000000000000000000000000000000000000000000002343 205.0
TLS2_k127_1337991_21 Protein of unknown function (DUF1538) - - - 0.000000000000000000000000000000000000000000000000002051 201.0
TLS2_k127_1337991_22 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000000000000000000000000002597 165.0
TLS2_k127_1337991_23 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000004912 144.0
TLS2_k127_1337991_24 - - - - 0.000000000000000000000000000000000001074 155.0
TLS2_k127_1337991_25 Belongs to the P(II) protein family - - - 0.00000000000000000000000000000000000131 142.0
TLS2_k127_1337991_26 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.0000000000000000000000002423 122.0
TLS2_k127_1337991_3 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006683 492.0
TLS2_k127_1337991_4 G-rich domain on putative tyrosine kinase K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 437.0
TLS2_k127_1337991_5 PFAM Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 415.0
TLS2_k127_1337991_6 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 402.0
TLS2_k127_1337991_7 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 390.0
TLS2_k127_1337991_8 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007303 377.0
TLS2_k127_1337991_9 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002898 353.0
TLS2_k127_1342608_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 359.0
TLS2_k127_1342608_1 Aldo/keto reductase family K00064 - 1.1.1.122 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 313.0
TLS2_k127_1342608_2 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.000000000000000000000000011 111.0
TLS2_k127_135036_0 Class II Aldolase and Adducin N-terminal domain K22130 - 4.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002411 281.0
TLS2_k127_135036_1 Putative sugar-binding N-terminal domain K21948 - 2.7.1.217 0.0000000000000000000000000000000000000000000000000000000000000000000000000001249 262.0
TLS2_k127_135036_2 cyclic nucleotide-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001772 283.0
TLS2_k127_135036_3 Glyoxalase bleomycin resistance protein dioxygenase K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.0000000000000000000000000000000000000000000000008939 178.0
TLS2_k127_135036_4 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000001736 113.0
TLS2_k127_1360876_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000008014 228.0
TLS2_k127_1360876_1 CHRD domain - - - 0.000000000000000000000000000000000001095 145.0
TLS2_k127_1360876_2 Transglycosylase associated protein - - - 0.00000000000000000000000000004181 117.0
TLS2_k127_1360876_3 transposase activity - - - 0.00000001381 57.0
TLS2_k127_13705_0 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 2.715e-244 762.0
TLS2_k127_13705_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 598.0
TLS2_k127_13705_10 COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 377.0
TLS2_k127_13705_11 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 370.0
TLS2_k127_13705_12 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005484 331.0
TLS2_k127_13705_13 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000256 274.0
TLS2_k127_13705_14 Cupin - - - 0.00000000000000000000000000000000000000000000000000007396 188.0
TLS2_k127_13705_15 - - - - 0.00000000000000000000000000000000001314 151.0
TLS2_k127_13705_16 Uncharacterised protein conserved in bacteria (DUF2336) - - - 0.00000000000000000000000000000000002595 151.0
TLS2_k127_13705_17 HicB family K18843 - - 0.000000000000000000000001117 108.0
TLS2_k127_13705_18 BrnA antitoxin of type II toxin-antitoxin system - - - 0.00000000000000000004591 95.0
TLS2_k127_13705_19 - - - - 0.00000000000000000007686 94.0
TLS2_k127_13705_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007852 563.0
TLS2_k127_13705_20 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000003323 85.0
TLS2_k127_13705_3 Acyclic terpene utilisation family protein AtuA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 530.0
TLS2_k127_13705_4 FAD binding domain K05712,K16022,K20943,K20944 - 1.14.13.127,1.14.13.219,1.14.13.220 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 517.0
TLS2_k127_13705_5 TOBE domain K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 414.0
TLS2_k127_13705_6 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00050 - 1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 407.0
TLS2_k127_13705_7 ABC transporter K06158 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 397.0
TLS2_k127_13705_8 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 388.0
TLS2_k127_13705_9 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 373.0
TLS2_k127_1385445_0 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006063 480.0
TLS2_k127_1385445_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007187 275.0
TLS2_k127_1385445_2 metabolite transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001101 258.0
TLS2_k127_1385445_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000004289 232.0
TLS2_k127_1385445_4 YceI-like domain - - - 0.000000000000000000000000000000000000000006131 162.0
TLS2_k127_1385445_5 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000002605 90.0
TLS2_k127_1401968_0 Binding-protein-dependent transport system inner membrane component K02001 - - 1.095e-224 731.0
TLS2_k127_1401968_1 COG4175 ABC-type proline glycine betaine transport system ATPase component K02000 - 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 452.0
TLS2_k127_1401968_2 Choline/ethanolamine kinase - - - 0.000000000000000000000000000000000000000000000000000004355 208.0
TLS2_k127_1401968_3 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.000000000000000000000000000000003511 128.0
TLS2_k127_1408952_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 486.0
TLS2_k127_1408952_1 Amino-transferase class IV K00824 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 337.0
TLS2_k127_1408952_2 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000001813 167.0
TLS2_k127_1408952_3 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000000000000000000000000005278 139.0
TLS2_k127_1408952_4 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.00000000000000000000000000005966 116.0
TLS2_k127_1409439_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 9.376e-204 662.0
TLS2_k127_1409439_1 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 556.0
TLS2_k127_1409439_2 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 285.0
TLS2_k127_1409439_3 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006903 246.0
TLS2_k127_1409439_4 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000002505 230.0
TLS2_k127_1409439_5 synthetase K01908 - 6.2.1.17 0.0000000000000000000000000000000000009593 140.0
TLS2_k127_1424363_0 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 501.0
TLS2_k127_1424363_1 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 454.0
TLS2_k127_1424363_2 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 330.0
TLS2_k127_1445204_0 COG1178 ABC-type Fe3 transport system, permease component K02011 - - 3.135e-210 670.0
TLS2_k127_1445204_1 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 546.0
TLS2_k127_1445204_2 Alpha/beta hydrolase family K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007744 426.0
TLS2_k127_1445204_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 295.0
TLS2_k127_1448406_0 Transposase, Mutator family - - - 8.577e-213 668.0
TLS2_k127_145043_0 Sodium:sulfate symporter transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 438.0
TLS2_k127_145043_1 - - - - 0.000000004351 63.0
TLS2_k127_145043_2 Methyltransferase - - - 0.0001668 44.0
TLS2_k127_1461309_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 598.0
TLS2_k127_1461309_1 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008931 567.0
TLS2_k127_1461309_2 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 375.0
TLS2_k127_1461309_3 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 360.0
TLS2_k127_1461309_4 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.0000000000000000000000000000000000000000000000000000000000000000002279 236.0
TLS2_k127_1461309_5 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000003657 249.0
TLS2_k127_1461309_6 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000000000000000000000001723 211.0
TLS2_k127_1461309_7 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000000009372 143.0
TLS2_k127_1463635_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 3.214e-198 631.0
TLS2_k127_1463635_1 NAD dependent epimerase/dehydratase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 419.0
TLS2_k127_1463635_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002574 387.0
TLS2_k127_1463635_3 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 374.0
TLS2_k127_1463635_4 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002725 266.0
TLS2_k127_1463635_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000009026 147.0
TLS2_k127_1486501_0 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 434.0
TLS2_k127_1486501_1 Tellurite resistance protein TerB K05801 - - 0.000000000000000000000000000000000000000000000000000000000000000005104 229.0
TLS2_k127_1519643_0 Belongs to the thiolase family K00626 - 2.3.1.9 3.595e-202 636.0
TLS2_k127_1519643_1 alpha/beta hydrolase fold K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 343.0
TLS2_k127_1519643_2 Flp pilus assembly protein, pilin Flp K02651 - - 0.0000000009392 61.0
TLS2_k127_1577360_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 596.0
TLS2_k127_1577360_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 584.0
TLS2_k127_1577360_10 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000003095 247.0
TLS2_k127_1577360_11 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000366 221.0
TLS2_k127_1577360_12 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000000000000000000000004607 220.0
TLS2_k127_1577360_13 ROS/MUCR transcriptional regulator protein - - - 0.000000000000000000000000000000000000000000000000000000002372 206.0
TLS2_k127_1577360_14 Protein of unknown function (DUF2892) - - - 0.00000000000000000000000000000000000000000000000000186 188.0
TLS2_k127_1577360_15 transcriptional - - - 0.0000000000000000000000000000000000000000000000001872 181.0
TLS2_k127_1577360_16 COG4665 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.000000000000000000000000000000000000000000261 167.0
TLS2_k127_1577360_17 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000000009649 164.0
TLS2_k127_1577360_18 Aldolase/RraA - - - 0.00000000000000000000000000000000000000009384 160.0
TLS2_k127_1577360_19 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000001519 122.0
TLS2_k127_1577360_2 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 551.0
TLS2_k127_1577360_20 Nucleotidyltransferase domain K07075 - - 0.00000000000000000000000002174 116.0
TLS2_k127_1577360_21 COG1214 Inactive homolog of metal-dependent proteases K14742 - - 0.000000000000000009204 98.0
TLS2_k127_1577360_3 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004638 422.0
TLS2_k127_1577360_4 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 418.0
TLS2_k127_1577360_5 PhoH-like protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005922 406.0
TLS2_k127_1577360_6 PFAM Enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 316.0
TLS2_k127_1577360_7 Mandelate Racemase Muconate Lactonizing - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005234 283.0
TLS2_k127_1577360_8 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009065 270.0
TLS2_k127_1577360_9 COG1253 Hemolysins and related proteins containing CBS domains K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003035 279.0
TLS2_k127_1607740_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006295 269.0
TLS2_k127_1607740_1 ABC-type multidrug transport system ATPase and permease K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000001036 237.0
TLS2_k127_1611147_0 Enterobacterial virulence protein IpgD - - - 0.0000000000000000000000000000000000000000000000000000000008968 227.0
TLS2_k127_1611147_1 UbiA prenyltransferase family - - - 0.00000000000000000000000000000001751 130.0
TLS2_k127_1611147_2 - - - - 0.0000000000000000000000009278 120.0
TLS2_k127_1611147_3 Type III K03229 - - 0.0000000000000000006991 87.0
TLS2_k127_1611147_4 - - - - 0.0000000000005984 79.0
TLS2_k127_1611147_6 Tir chaperone protein (CesT) family - - - 0.0000006183 58.0
TLS2_k127_1626516_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 345.0
TLS2_k127_1626516_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 324.0
TLS2_k127_1626516_2 Glucose / Sorbosone dehydrogenase K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001084 293.0
TLS2_k127_1626516_3 Nitrile hydratase, alpha chain K01721,K20807 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003595 278.0
TLS2_k127_1626516_4 Glutathione S-transferase, N-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005593 256.0
TLS2_k127_1626516_5 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000000000000000000000004441 128.0
TLS2_k127_1626516_6 Universal stress protein family - - - 0.000000000000000000000000000002049 127.0
TLS2_k127_1626516_7 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000000000000000000002967 125.0
TLS2_k127_1626516_8 Universal stress protein family - - - 0.00000000000000000000000000003243 122.0
TLS2_k127_1629621_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 3.499e-221 695.0
TLS2_k127_1629621_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 2.071e-201 637.0
TLS2_k127_1629621_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004699 488.0
TLS2_k127_1629621_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009213 460.0
TLS2_k127_1629621_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 439.0
TLS2_k127_1629621_6 Pentapeptide repeats (8 copies) - - - 0.0000000000000000000007188 99.0
TLS2_k127_1629621_7 Domain of unknown function DUF29 - - - 0.0000000000000000000007641 106.0
TLS2_k127_1629621_8 Polyketide cyclase / dehydrase and lipid transport K18588 - - 0.0000004986 51.0
TLS2_k127_1629621_9 - - - - 0.00001274 51.0
TLS2_k127_163292_0 MmgE PrpD family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002081 549.0
TLS2_k127_163292_1 Polysaccharide deacetylase K01452 - 3.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 507.0
TLS2_k127_163292_2 Domain of unknown function DUF108 - - - 0.0001622 52.0
TLS2_k127_163292_3 FCD - - - 0.0008002 42.0
TLS2_k127_1666604_0 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 446.0
TLS2_k127_1666604_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 389.0
TLS2_k127_167780_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004682 473.0
TLS2_k127_167780_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000381 366.0
TLS2_k127_167780_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 310.0
TLS2_k127_167780_3 50S ribosomal protein L4 K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001236 254.0
TLS2_k127_167780_4 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000000005413 166.0
TLS2_k127_167780_5 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000002922 167.0
TLS2_k127_167780_6 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000000000000000000007198 146.0
TLS2_k127_167780_7 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000002728 87.0
TLS2_k127_1696916_0 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002164 247.0
TLS2_k127_1696916_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000002257 222.0
TLS2_k127_1696916_2 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000001059 165.0
TLS2_k127_1696916_3 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000002469 169.0
TLS2_k127_1696916_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000007665 128.0
TLS2_k127_1696916_5 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000008143 96.0
TLS2_k127_1696916_6 transcriptional regulator - - - 0.0000000000001841 72.0
TLS2_k127_1696916_7 - - - - 0.000001052 57.0
TLS2_k127_1696916_8 Polysaccharide biosynthesis protein - - - 0.000007276 59.0
TLS2_k127_170075_0 glucose sorbosone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 455.0
TLS2_k127_170075_1 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 420.0
TLS2_k127_170075_2 P-aminobenzoate N-oxygenase AurF - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 410.0
TLS2_k127_170075_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 351.0
TLS2_k127_170075_4 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 335.0
TLS2_k127_170075_5 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000001648 236.0
TLS2_k127_1756989_0 Glycosyl hydrolases family 15 - - - 4.935e-244 768.0
TLS2_k127_1756989_1 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 330.0
TLS2_k127_1756989_2 COG0438 Glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000002083 191.0
TLS2_k127_1767032_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 1.035e-280 878.0
TLS2_k127_1767032_1 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000001205 186.0
TLS2_k127_1767032_2 Sarcosine oxidase, gamma subunit family K00305 - 1.5.3.1 0.0000000000000000000000002799 109.0
TLS2_k127_176760_0 Formate dehydrogenase subunit alpha - - - 0.0 1431.0
TLS2_k127_176760_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001666 284.0
TLS2_k127_176760_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000001846 180.0
TLS2_k127_176760_3 molybdopterin K03750 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 0.000000000000000000000000000000000000000000001992 168.0
TLS2_k127_176760_4 - - - - 0.00000000000001244 89.0
TLS2_k127_176760_5 - - - - 0.00000009437 57.0
TLS2_k127_1841844_0 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 400.0
TLS2_k127_1841844_1 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 321.0
TLS2_k127_1841844_2 glutamate--cysteine ligase K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000008799 232.0
TLS2_k127_1841844_3 PIN domain - - - 0.0000000000000000004134 90.0
TLS2_k127_1841844_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000001341 83.0
TLS2_k127_1841844_5 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.0000000001514 64.0
TLS2_k127_1841844_6 to nucleic acid-binding protein contains PIN domain - - - 0.00001301 54.0
TLS2_k127_1844456_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 3.449e-260 816.0
TLS2_k127_1844456_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 4.307e-250 779.0
TLS2_k127_1844456_10 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000006928 135.0
TLS2_k127_1844456_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000007552 126.0
TLS2_k127_1844456_12 - - - - 0.000000006681 61.0
TLS2_k127_1844456_2 Amidase, hydantoinase carbamoylase family K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 511.0
TLS2_k127_1844456_3 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 464.0
TLS2_k127_1844456_4 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007332 438.0
TLS2_k127_1844456_5 (GMC) oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 408.0
TLS2_k127_1844456_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003917 372.0
TLS2_k127_1844456_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000333 215.0
TLS2_k127_1844456_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000000000000003509 196.0
TLS2_k127_1844456_9 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000000000000000000000000000000000001499 144.0
TLS2_k127_186247_0 Periplasmic binding proteins and sugar binding domain of LacI family K10439,K17202,K17205,K17213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000294 271.0
TLS2_k127_186247_1 Belongs to the binding-protein-dependent transport system permease family K10440,K17214 - - 0.0000000000000000002499 89.0
TLS2_k127_186247_2 PFAM ABC transporter related K02056,K10441 - 3.6.3.17 0.00000000000002195 77.0
TLS2_k127_1876523_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006682 588.0
TLS2_k127_1876523_1 COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 - 1.6.5.3 0.000000000000000000000000000000000001777 140.0
TLS2_k127_1880440_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 352.0
TLS2_k127_1880440_1 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000002799 273.0
TLS2_k127_1880440_2 Belongs to the globin family - - - 0.0009165 42.0
TLS2_k127_1886528_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 2.687e-307 957.0
TLS2_k127_1886528_1 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 375.0
TLS2_k127_1886528_2 Putative restriction endonuclease - - - 0.000000000000000000000000000006663 126.0
TLS2_k127_1886528_3 - - - - 0.000000000000000000627 87.0
TLS2_k127_1886528_4 COG2913 Small protein A (tmRNA-binding) - - - 0.0000000000000001179 81.0
TLS2_k127_1890410_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1393.0
TLS2_k127_1890410_1 Citrate transporter - - - 5.184e-236 737.0
TLS2_k127_1890410_2 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 574.0
TLS2_k127_1890410_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 396.0
TLS2_k127_1890410_4 Mechanosensitive ion channel K22044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 330.0
TLS2_k127_1890410_5 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 328.0
TLS2_k127_1890410_6 MltA-interacting protein MipA - - - 0.000000000000000000000000000000000000000000000000000000000003013 218.0
TLS2_k127_1890410_7 protein involved in outer membrane biogenesis K07290 - - 0.000000006922 65.0
TLS2_k127_1895634_0 Belongs to the GcvT family K00302,K22086 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1,1.5.99.5 1.041e-270 856.0
TLS2_k127_1895634_1 epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 392.0
TLS2_k127_1895634_10 - - - - 0.0000000008907 63.0
TLS2_k127_1895634_2 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 311.0
TLS2_k127_1895634_3 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002184 259.0
TLS2_k127_1895634_4 integral membrane protein - - - 0.0000000000000000000000000000000000000000000000008055 179.0
TLS2_k127_1895634_5 Sarcosine oxidase, gamma subunit K00305,K22087 - 1.5.3.1,1.5.99.5 0.00000000000000000000000000004221 124.0
TLS2_k127_1895634_6 Dodecin K09165 - - 0.0000000000000000000002075 102.0
TLS2_k127_1895634_8 - - - - 0.0000000000000006537 86.0
TLS2_k127_1895634_9 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000805 80.0
TLS2_k127_1899330_0 Integrase core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 354.0
TLS2_k127_1899330_1 DDE (Asp,Asp,Glu) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001427 278.0
TLS2_k127_1899330_2 DDE (Asp,Asp,Glu) domain - - - 0.000000000000000000000000000000006358 131.0
TLS2_k127_1908579_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 4.087e-295 919.0
TLS2_k127_1908579_1 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K14446 - 1.3.1.85 8.258e-227 714.0
TLS2_k127_1908579_10 Belongs to the ompA family - - - 0.00000000000000000000009225 105.0
TLS2_k127_1908579_11 small membrane protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0001122 49.0
TLS2_k127_1908579_12 C-terminal PDZ domain K04771 - 3.4.21.107 0.0001592 54.0
TLS2_k127_1908579_2 COG1960 Acyl-CoA dehydrogenases K14448 - 1.3.8.12 2.291e-201 665.0
TLS2_k127_1908579_3 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 526.0
TLS2_k127_1908579_4 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001653 428.0
TLS2_k127_1908579_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 410.0
TLS2_k127_1908579_6 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 303.0
TLS2_k127_1908579_7 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000003034 252.0
TLS2_k127_1908579_8 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.000000000000000000000000000000000000000000000000000000000000001197 239.0
TLS2_k127_1908579_9 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000003414 214.0
TLS2_k127_190865_0 Transposase - - - 1.564e-273 851.0
TLS2_k127_190865_1 IS66 Orf2 like protein K07484 - - 0.00000000000000000000000000000000000000000000000000000000000000004117 230.0
TLS2_k127_190865_2 - - - - 0.0000000000000000000000000000000001329 152.0
TLS2_k127_190865_3 Transposase K07483 - - 0.0000000000000000000000000000000007284 134.0
TLS2_k127_190865_4 - - - - 0.000000232 53.0
TLS2_k127_1913564_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 393.0
TLS2_k127_1913564_1 - - - - 0.000000000000001106 83.0
TLS2_k127_1914060_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1003.0
TLS2_k127_1918299_0 TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family K00114 - 1.1.2.8 3.176e-226 713.0
TLS2_k127_1918299_1 MMPL family K07003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 552.0
TLS2_k127_1918299_10 Lipid A 3-O-deacylase (PagL) - - - 0.0000000000000000000000000000000001227 147.0
TLS2_k127_1918299_11 Domain of unknown function (DUF3463) - - - 0.000000000000000000003168 96.0
TLS2_k127_1918299_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 490.0
TLS2_k127_1918299_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 443.0
TLS2_k127_1918299_4 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007722 409.0
TLS2_k127_1918299_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 369.0
TLS2_k127_1918299_6 hydrolase (HAD superfamily) K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005015 284.0
TLS2_k127_1918299_7 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.000000000000000000000000000000000000000000000000000000006737 202.0
TLS2_k127_1918299_8 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000002285 175.0
TLS2_k127_1918299_9 MlaC protein K07323 - - 0.0000000000000000000000000000000000000000000003528 177.0
TLS2_k127_1918649_0 Hydantoinaseoxoprolinase domain protein K01469,K01473 - 3.5.2.14,3.5.2.9 8.169e-242 766.0
TLS2_k127_1918649_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 9.403e-226 712.0
TLS2_k127_1918649_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000002416 158.0
TLS2_k127_1918649_11 methyltransferase - - - 0.00000000000000000000000000000000000003817 157.0
TLS2_k127_1918649_12 Domain of unknown function (DUF4397) - - - 0.0000000000000000000000000000006141 131.0
TLS2_k127_1918649_13 - - - - 0.00000000001282 75.0
TLS2_k127_1918649_14 Transposase DDE domain - - - 0.000005584 59.0
TLS2_k127_1918649_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.127e-212 666.0
TLS2_k127_1918649_3 Serine dehydratase - - - 1.946e-194 616.0
TLS2_k127_1918649_4 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 606.0
TLS2_k127_1918649_5 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 556.0
TLS2_k127_1918649_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 402.0
TLS2_k127_1918649_7 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003065 269.0
TLS2_k127_1918649_8 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000000000000000000001634 220.0
TLS2_k127_1918649_9 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000001293 173.0
TLS2_k127_1919437_0 ROK family K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 306.0
TLS2_k127_192025_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 4.113e-306 957.0
TLS2_k127_192025_1 glyoxalase bleomycin resistance protein dioxygenase K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.0000000000000000000000000000000000000000000000000001634 185.0
TLS2_k127_1921530_0 Transposase DDE domain - - - 4.311e-201 641.0
TLS2_k127_1921530_1 PFAM Transposase, IS4-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 314.0
TLS2_k127_1921530_2 - - - - 0.00000001109 63.0
TLS2_k127_193439_0 AAA ATPase domain - - - 0.0 1149.0
TLS2_k127_1937588_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 590.0
TLS2_k127_1937588_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006566 271.0
TLS2_k127_1937588_2 - - - - 0.0000000000003067 76.0
TLS2_k127_1944676_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1217.0
TLS2_k127_1944676_1 Acetamidase/Formamidase family K01455 - 3.5.1.49 1.712e-236 760.0
TLS2_k127_1944676_2 histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 357.0
TLS2_k127_1944676_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07659 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005961 342.0
TLS2_k127_1944676_4 AmiS/UreI family transporter K22112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001158 253.0
TLS2_k127_1944676_5 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000004073 164.0
TLS2_k127_1944676_6 Regulatory protein, FmdB family - - - 0.0000000000000001194 85.0
TLS2_k127_1951886_0 Site-specific recombinase, DNA invertase Pin - - - 4.567e-311 975.0
TLS2_k127_1951886_1 Site-specific recombinase, DNA invertase Pin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009598 257.0
TLS2_k127_1951886_2 DNA invertase Pin - - - 0.000000000000000000000000000000000000000000000000000000000002419 212.0
TLS2_k127_1951886_3 IS66 C-terminal element - - - 0.0000000000000000000001453 97.0
TLS2_k127_1951886_6 Belongs to the 'phage' integrase family - - - 0.00000000000009831 74.0
TLS2_k127_1951886_7 - - - - 0.00000000097 69.0
TLS2_k127_1957742_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01534,K17686 - 3.6.3.3,3.6.3.5,3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008228 449.0
TLS2_k127_1957742_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 425.0
TLS2_k127_1966951_0 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 432.0
TLS2_k127_1966951_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000000000000000000000000000000000000000000000003209 214.0
TLS2_k127_1966951_2 transposase activity - - - 0.0000000000002958 74.0
TLS2_k127_1966951_3 transposase activity - - - 0.00000006091 59.0
TLS2_k127_1971517_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.806e-218 702.0
TLS2_k127_1971517_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 617.0
TLS2_k127_1971517_10 - - - - 0.000000000000000000000000000000000000000000000000002135 185.0
TLS2_k127_1971517_11 LysM domain - - - 0.000000000000000000000000000000000000000000000000209 185.0
TLS2_k127_1971517_12 PAAR motif - - - 0.0000000000000000000000000000000000000000000000002531 179.0
TLS2_k127_1971517_13 Belongs to the HesB IscA family K13628,K15724 - - 0.000000000000000000000000000000000000003874 148.0
TLS2_k127_1971517_14 Phage baseplate assembly protein W K06903 - - 0.0000000000000000000000000002764 123.0
TLS2_k127_1971517_15 Baseplate J-like protein - - - 0.000000000000000000000002916 119.0
TLS2_k127_1971517_16 peptidase inhibitor activity - - - 0.000000000000000000001118 107.0
TLS2_k127_1971517_17 - - - - 0.00000000000885 72.0
TLS2_k127_1971517_2 Phage tail sheath protein K06907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 524.0
TLS2_k127_1971517_3 PFAM ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003629 508.0
TLS2_k127_1971517_4 deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 494.0
TLS2_k127_1971517_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 312.0
TLS2_k127_1971517_6 exodeoxyribonuclease III K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005844 282.0
TLS2_k127_1971517_7 Phage late control gene D protein (GPD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005766 258.0
TLS2_k127_1971517_8 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000000000005078 228.0
TLS2_k127_1971517_9 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000000000000000000000000000004788 208.0
TLS2_k127_1972570_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 556.0
TLS2_k127_1972570_1 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.000000000000000000000000000000000000000000405 160.0
TLS2_k127_1975083_0 Binding-protein-dependent transport system inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 462.0
TLS2_k127_1975083_1 Dihydrodipicolinate synthetase family K13876 - 4.2.1.43 0.000000000000000000000000000000000000000000000000000000000000000002538 233.0
TLS2_k127_1975083_2 Binding-protein-dependent transport system inner membrane component K02053 - - 0.000000000000003407 78.0
TLS2_k127_1981542_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 2.929e-258 812.0
TLS2_k127_1981542_1 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 357.0
TLS2_k127_1981542_2 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000001042 249.0
TLS2_k127_1981542_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000003143 154.0
TLS2_k127_1993234_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 436.0
TLS2_k127_1993234_1 Universal stress protein family - - - 0.000000000000000000000000000000000000000000008028 167.0
TLS2_k127_201235_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 8.868e-242 751.0
TLS2_k127_201235_1 Domain of unknown function DUF29 - - - 0.0000000000001278 72.0
TLS2_k127_202363_0 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 372.0
TLS2_k127_202363_1 BtpA family K06971 - - 0.00000000000000000000000000000000000000000000000000000000000000004221 227.0
TLS2_k127_2025022_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 511.0
TLS2_k127_2025022_1 Queuosine biosynthesis protein K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000002274 200.0
TLS2_k127_2025022_2 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.00000000000000004452 85.0
TLS2_k127_2025022_3 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.0000000987 60.0
TLS2_k127_20277_0 Hydantoinase/oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 3.571e-301 968.0
TLS2_k127_20277_1 Hydantoinase B/oxoprolinase - - - 6.074e-301 935.0
TLS2_k127_20277_2 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002981 583.0
TLS2_k127_20277_3 HAD-hyrolase-like K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000004482 174.0
TLS2_k127_2029395_0 Transglycosylase - - - 3.935e-299 948.0
TLS2_k127_2029395_1 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 1.434e-250 790.0
TLS2_k127_2029395_2 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 1.792e-204 651.0
TLS2_k127_2029395_3 Multicopper oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000704 467.0
TLS2_k127_2029395_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 467.0
TLS2_k127_2029395_5 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 308.0
TLS2_k127_2030650_0 FAD dependent oxidoreductase - - - 1.403e-215 678.0
TLS2_k127_2030650_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 358.0
TLS2_k127_2030650_10 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.0000008636 54.0
TLS2_k127_2030650_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005184 334.0
TLS2_k127_2030650_3 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 GO:0003674,GO:0003824,GO:0004845,GO:0004849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016763,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 321.0
TLS2_k127_2030650_4 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000001237 224.0
TLS2_k127_2030650_5 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000000000000000000001224 195.0
TLS2_k127_2030650_6 ADP-ribosylglycohydrolase - - - 0.00000000000000000000000000002626 122.0
TLS2_k127_2030650_7 Type III secretion system lipoprotein chaperone (YscW) K09914 - - 0.0000000000000000000006325 100.0
TLS2_k127_2030650_8 PFAM sodium alanine symporter K03310 - - 0.0000000000000000000009833 96.0
TLS2_k127_2030650_9 Rhomboid family - - - 0.000000000000001624 89.0
TLS2_k127_2034408_0 Protein of unknown function (DUF3141) - - - 1.83e-232 739.0
TLS2_k127_2034408_1 phosphate acetyltransferase K00625,K00634 - 2.3.1.19,2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 580.0
TLS2_k127_2034408_10 - - - - 0.0000001649 61.0
TLS2_k127_2034408_12 transposase activity - - - 0.00005458 49.0
TLS2_k127_2034408_2 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008537 495.0
TLS2_k127_2034408_3 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006672 376.0
TLS2_k127_2034408_4 Coenzyme A transferase K01029,K01035 - 2.8.3.5,2.8.3.8,2.8.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 353.0
TLS2_k127_2034408_5 TIGRFAM 3-hydroxybutyrate dehydrogenase K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 357.0
TLS2_k127_2034408_6 Coenzyme A transferase K01034 - 2.8.3.8,2.8.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 329.0
TLS2_k127_2034408_7 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000007804 243.0
TLS2_k127_2034408_8 IMP dehydrogenase activity - - - 0.00000000000000000000000000000000003868 151.0
TLS2_k127_2042148_0 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009566 320.0
TLS2_k127_2042148_1 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000005847 233.0
TLS2_k127_2042148_2 dehydrogenases and related proteins K00010 - 1.1.1.18,1.1.1.369 0.000000000000000000000000000000000000000002729 158.0
TLS2_k127_2042148_3 OsmC-like protein - - - 0.00000000000000000000000000000000000000001968 158.0
TLS2_k127_2054761_0 COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain K13924 - 2.1.1.80,3.1.1.61 2.356e-245 794.0
TLS2_k127_2054761_1 Predicted membrane protein (DUF2243) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000056 317.0
TLS2_k127_2054761_2 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000115 182.0
TLS2_k127_2054761_3 - - - - 0.00000000000000000000000000002035 119.0
TLS2_k127_2077578_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 5.888e-218 694.0
TLS2_k127_2077578_1 Diguanylate cyclase - - - 2.369e-199 650.0
TLS2_k127_2077578_10 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000000000000000000000000000000000000000000000000000101 197.0
TLS2_k127_2077578_11 methyltransferase activity - - - 0.000000000000000000000000000000004387 133.0
TLS2_k127_2077578_12 Putative restriction endonuclease - - - 0.000000000000000000000000000222 123.0
TLS2_k127_2077578_13 Protein of unknown function (DUF3775) - - - 0.0000000000000000000000005928 117.0
TLS2_k127_2077578_14 membrane - - - 0.0000000000000000000000006995 112.0
TLS2_k127_2077578_15 MarR family - - - 0.00000000000000000001288 94.0
TLS2_k127_2077578_16 BrnA antitoxin of type II toxin-antitoxin system - - - 0.00000000000000000002979 94.0
TLS2_k127_2077578_17 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000001248 83.0
TLS2_k127_2077578_18 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000003585 81.0
TLS2_k127_2077578_19 virion core protein (lumpy skin disease virus) - - - 0.0000008365 59.0
TLS2_k127_2077578_2 Beta-ketoacyl synthase, N-terminal domain K00626,K00632,K02615 GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0006805,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016740,GO:0016746,GO:0016747,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0033554,GO:0033812,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 2.3.1.16,2.3.1.174,2.3.1.223,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 581.0
TLS2_k127_2077578_20 deoxyhypusine monooxygenase activity - - - 0.00008611 53.0
TLS2_k127_2077578_3 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 527.0
TLS2_k127_2077578_4 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 435.0
TLS2_k127_2077578_5 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 373.0
TLS2_k127_2077578_6 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 355.0
TLS2_k127_2077578_7 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001878 241.0
TLS2_k127_2077578_8 Enoyl-(Acyl carrier protein) reductase K21883 - 1.1.1.401 0.00000000000000000000000000000000000000000000000000000000000000394 228.0
TLS2_k127_2077578_9 2-keto-4-pentenoate hydratase K02554 - 4.2.1.80 0.000000000000000000000000000000000000000000000000000002094 200.0
TLS2_k127_2078845_0 Polycystin cation channel K08714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006811 345.0
TLS2_k127_2078845_1 branched-chain amino acid K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 342.0
TLS2_k127_2078845_2 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007615 275.0
TLS2_k127_2081036_0 cell septum assembly K02487,K06596,K08372 - - 0.000000000000000000000000000000000000000002159 173.0
TLS2_k127_2081036_1 cell septum assembly K02487,K06596,K08372 - - 0.00000002792 64.0
TLS2_k127_2081106_0 Baseplate J-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007122 347.0
TLS2_k127_2081106_1 homolog of phage Mu protein gp47 - - - 0.0000000000000000000000000000000004393 142.0
TLS2_k127_2081106_2 cell septum assembly K02487,K06596,K08372 - - 0.0000000002948 64.0
TLS2_k127_2081106_3 tail collar domain protein - - - 0.00000000158 70.0
TLS2_k127_2081106_4 Tail protein - - - 0.0000008451 61.0
TLS2_k127_2082572_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 1.934e-259 837.0
TLS2_k127_2082572_1 PFAM Rh family protein ammonium transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004112 564.0
TLS2_k127_2082572_2 COG0436 Aspartate tyrosine aromatic aminotransferase K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 454.0
TLS2_k127_2082572_3 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 399.0
TLS2_k127_2083644_0 PFAM ABC transporter K02056 - 3.6.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 325.0
TLS2_k127_2083644_1 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000006254 242.0
TLS2_k127_2104346_0 Pyrrolo-quinoline quinone K00114 - 1.1.2.8 1.444e-278 866.0
TLS2_k127_2104346_1 COG0471 Di- and tricarboxylate transporters - - - 7.431e-214 680.0
TLS2_k127_2104346_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 406.0
TLS2_k127_2104346_3 peptidase M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 334.0
TLS2_k127_2104346_4 Extracellular solute-binding protein, family 3 K16254 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009387 293.0
TLS2_k127_2104346_5 permease - - - 0.000000000000000000000000000000000000000000000000000000000000000002561 244.0
TLS2_k127_2104346_6 PFAM Cytochrome C K00406 - - 0.000000000000000000000000000000001148 139.0
TLS2_k127_2104346_7 signal-transduction protein containing cAMP-binding and CBS domains - - - 0.000000000000000000003369 108.0
TLS2_k127_2107202_0 Belongs to the ABC transporter superfamily K02031,K02032,K13892 - - 1.875e-274 863.0
TLS2_k127_2107202_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 2.822e-201 634.0
TLS2_k127_2107202_10 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000001101 97.0
TLS2_k127_2107202_11 plasmid stabilization protein K21495 - - 0.000000000000000008997 87.0
TLS2_k127_2107202_12 Belongs to the ABC transporter superfamily K02031,K02032,K13892 - - 0.00000000008397 64.0
TLS2_k127_2107202_13 Cytochrome c - - - 0.0004444 48.0
TLS2_k127_2107202_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009321 380.0
TLS2_k127_2107202_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 359.0
TLS2_k127_2107202_4 malonyl CoA-acyl carrier protein transacylase K00645 GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 355.0
TLS2_k127_2107202_5 short-chain dehydrogenase reductase SDR K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 336.0
TLS2_k127_2107202_6 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.0000000000000000000000000000000000000000000319 166.0
TLS2_k127_2107202_7 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000004626 150.0
TLS2_k127_2107202_8 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000000001056 133.0
TLS2_k127_2107202_9 PFAM YcfA-like - - - 0.000000000000000000000000001464 113.0
TLS2_k127_2108960_0 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 3.821e-290 907.0
TLS2_k127_2113825_0 Protein of unknown function DUF262 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001648 254.0
TLS2_k127_2113825_1 cell septum assembly K02487,K06596,K08372 - - 0.00000000000000000000000000000000000002348 164.0
TLS2_k127_2116351_0 ABC transporter substrate-binding protein K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 587.0
TLS2_k127_2116351_1 ABC-type spermidine putrescine transport system, permease component I K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 554.0
TLS2_k127_2116351_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 549.0
TLS2_k127_2116351_3 aminotransferase class I and II K00375 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 534.0
TLS2_k127_2116351_4 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001655 276.0
TLS2_k127_2116351_5 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000001974 199.0
TLS2_k127_2116351_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000287 132.0
TLS2_k127_2116351_7 EamA-like transporter family - - - 0.000000000000000000000000000000501 127.0
TLS2_k127_2122628_0 This protein is involved in the repair of mismatches in DNA K03555 - - 5.084e-248 784.0
TLS2_k127_2125227_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 4.715e-293 918.0
TLS2_k127_2125227_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 377.0
TLS2_k127_2125227_2 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 355.0
TLS2_k127_2125227_3 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 296.0
TLS2_k127_2125227_4 Protein of unknown function (DUF1009) K09949 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006469 278.0
TLS2_k127_2125227_5 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000003927 216.0
TLS2_k127_2125227_6 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000005098 216.0
TLS2_k127_2125227_7 COG2825 Outer membrane protein - - - 0.0000000000000000000000000000000000000000002756 164.0
TLS2_k127_2130317_0 Zinc-uptake complex component A periplasmic K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009802 351.0
TLS2_k127_2130317_1 COG0488 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000002307 234.0
TLS2_k127_2130317_2 Glycine zipper - - - 0.00000000000000000000000000000000000000000000000000006323 196.0
TLS2_k127_2130317_3 Protein of unknown function (DUF1007) - - - 0.00000000000000000000008382 102.0
TLS2_k127_2133405_0 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 4.828e-252 784.0
TLS2_k127_2133405_1 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 460.0
TLS2_k127_2133405_2 PFAM peptidase S15 K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 455.0
TLS2_k127_2133405_3 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 458.0
TLS2_k127_2133405_4 ADP-glyceromanno-heptose 6-epimerase activity K00067,K01784,K17947 - 1.1.1.133,5.1.3.2,5.1.3.25 0.00000000000000000000000000000000000000000000000000005711 202.0
TLS2_k127_2133405_5 17 kDa outer membrane surface antigen - - - 0.0000000000000000000000000000000000000000000385 167.0
TLS2_k127_2133405_6 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000002847 155.0
TLS2_k127_2138190_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 597.0
TLS2_k127_2138190_1 Molybdopterin-binding domain of aldehyde dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 481.0
TLS2_k127_2138190_2 Protein of unknown function DUF111 K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 385.0
TLS2_k127_2138190_3 TIGRFAM TIGR00268 family protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 312.0
TLS2_k127_2138190_4 AIR carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002709 265.0
TLS2_k127_2138190_5 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518,K04107 - 1.2.5.3,1.3.7.9 0.0000000000000000000000000000000000000000000000000000602 191.0
TLS2_k127_2138190_6 CO dehydrogenase flavoprotein C-terminal domain - - - 0.000000000000000000000000000000000000000000000000002015 196.0
TLS2_k127_2155199_0 COG1042 Acyl-CoA synthetase (NDP forming) K09181 - - 0.0 1063.0
TLS2_k127_2155199_1 COG2217 Cation transport ATPase K01533 - 3.6.3.4 2.92e-267 853.0
TLS2_k127_2155199_10 - - - - 0.0000000000000001288 90.0
TLS2_k127_2155199_11 cytochrome oxidase maturation protein - - - 0.0000000000000002481 85.0
TLS2_k127_2155199_12 - - - - 0.0000000000000009014 84.0
TLS2_k127_2155199_13 Nitrogen fixation protein fixG - - - 0.0000000000009464 71.0
TLS2_k127_2155199_2 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 489.0
TLS2_k127_2155199_3 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004001 467.0
TLS2_k127_2155199_4 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 443.0
TLS2_k127_2155199_5 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 340.0
TLS2_k127_2155199_6 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000004821 268.0
TLS2_k127_2155199_7 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.00000000000000000000000000000000000000000000056 175.0
TLS2_k127_2155199_8 FixH - - - 0.000000000000000000000000000000000003201 147.0
TLS2_k127_2155199_9 - - - - 0.000000000000000001306 92.0
TLS2_k127_2156993_0 PFAM SMP-30 Gluconolaconase LRE domain protein K01053,K14274 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 528.0
TLS2_k127_2156993_1 Aldolase/RraA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000272 319.0
TLS2_k127_2156993_2 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000178 80.0
TLS2_k127_2159882_0 PFAM D-galactarate dehydratase Altronate hydrolase, C terminus K01685 - 4.2.1.7 4.553e-251 782.0
TLS2_k127_2159882_1 OsmC-like protein K06889,K07397 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004023 505.0
TLS2_k127_2159882_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 412.0
TLS2_k127_2159882_3 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002956 267.0
TLS2_k127_2159882_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005136 279.0
TLS2_k127_2159882_5 GtrA-like protein - - - 0.00000000000000000000000000000215 134.0
TLS2_k127_2159882_6 Domain of unknown function DUF29 - - - 0.000000000000000003495 89.0
TLS2_k127_2159882_7 - - - - 0.0000000000000000174 96.0
TLS2_k127_2159882_8 lipolytic protein G-D-S-L family - - - 0.0000001757 63.0
TLS2_k127_2161455_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 612.0
TLS2_k127_2161455_1 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 613.0
TLS2_k127_2161455_10 - - - - 0.0000000000001925 79.0
TLS2_k127_2161455_11 Lysylphosphatidylglycerol synthase TM region - - - 0.0000000009404 66.0
TLS2_k127_2161455_2 UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 406.0
TLS2_k127_2161455_3 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 373.0
TLS2_k127_2161455_4 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 316.0
TLS2_k127_2161455_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005053 321.0
TLS2_k127_2161455_6 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000051 255.0
TLS2_k127_2161455_7 DnaJ molecular chaperone homology domain - - - 0.000000000000000000000000000000000000000000003344 174.0
TLS2_k127_2161455_8 Protein of unknown function (DUF3618) - - - 0.0000000000000000003985 96.0
TLS2_k127_2161455_9 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000000000006459 84.0
TLS2_k127_2174415_0 Squalene-hopene cyclase C-terminal domain K06045 - 4.2.1.129,5.4.99.17 7.683e-277 865.0
TLS2_k127_2174415_1 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 496.0
TLS2_k127_2174415_2 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 437.0
TLS2_k127_2174415_3 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 308.0
TLS2_k127_2174415_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 301.0
TLS2_k127_2174415_5 MOSC domain - - - 0.00000000000000000000000000000000000000000002973 169.0
TLS2_k127_2174415_6 Belongs to the phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000001239 169.0
TLS2_k127_2174415_7 - - - - 0.00000000000000000000000000001582 129.0
TLS2_k127_2176661_0 Belongs to the glycosyltransferase 26 family - - - 0.0000000000000000000000000000000000000000000001621 181.0
TLS2_k127_2176661_1 O-Antigen ligase - - - 0.000000000000004208 88.0
TLS2_k127_2176661_2 Methyltransferase FkbM domain - - - 0.000001043 57.0
TLS2_k127_2176661_3 Methyltransferase FkbM domain - - - 0.00005449 52.0
TLS2_k127_21767_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 9.898e-297 927.0
TLS2_k127_21767_1 NAD(FAD)-dependent dehydrogenases K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 592.0
TLS2_k127_21767_10 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007422 347.0
TLS2_k127_21767_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 318.0
TLS2_k127_21767_12 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009859 312.0
TLS2_k127_21767_13 Transcriptional regulator, LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 293.0
TLS2_k127_21767_14 NYN domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000388 281.0
TLS2_k127_21767_15 uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003181 273.0
TLS2_k127_21767_16 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002679 268.0
TLS2_k127_21767_17 Imidazoleglycerol-phosphate dehydratase K00817,K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000003467 259.0
TLS2_k127_21767_18 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000004244 235.0
TLS2_k127_21767_19 Sulphur oxidation protein SoxZ K17226 - - 0.00000000000000000000000000000000000000000000000000000000000000008678 231.0
TLS2_k127_21767_2 COG1960 Acyl-CoA dehydrogenases K20035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 537.0
TLS2_k127_21767_20 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.000000000000000000000000000000000000000000000000000000000000001063 226.0
TLS2_k127_21767_21 Glutamine amidotransferase class-I K02501 - - 0.000000000000000000000000000000000000000000000000000000000158 217.0
TLS2_k127_21767_22 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000003156 222.0
TLS2_k127_21767_23 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000007628 202.0
TLS2_k127_21767_24 - - - - 0.00000000000000000000000000000000000000000000000000003085 194.0
TLS2_k127_21767_25 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000000000000000000000119 181.0
TLS2_k127_21767_26 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K13940 - 2.7.6.3,4.1.2.25 0.0000000000000000000000000000000000000000000006026 172.0
TLS2_k127_21767_27 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00000000000000000000000000000000002505 145.0
TLS2_k127_21767_28 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000000000000000000000000000000001689 137.0
TLS2_k127_21767_29 Cytochrome c - - - 0.00000000000000000004142 93.0
TLS2_k127_21767_3 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 521.0
TLS2_k127_21767_30 Cytochrome c - - - 0.0000000000000007919 85.0
TLS2_k127_21767_31 17 kDa outer membrane surface antigen - - - 0.00000000000001258 78.0
TLS2_k127_21767_32 mercury ion transmembrane transporter activity - - - 0.0000000000004072 74.0
TLS2_k127_21767_33 PRC-barrel domain - - - 0.000000000001859 76.0
TLS2_k127_21767_34 - - - - 0.000000000002724 74.0
TLS2_k127_21767_35 His Kinase A (phosphoacceptor) domain - - - 0.00000000001454 72.0
TLS2_k127_21767_36 Protein of unknown function (DUF5132) - - - 0.00000000005157 68.0
TLS2_k127_21767_37 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000004005 51.0
TLS2_k127_21767_4 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 398.0
TLS2_k127_21767_5 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001968 389.0
TLS2_k127_21767_6 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 383.0
TLS2_k127_21767_7 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004115 378.0
TLS2_k127_21767_8 YeeE YedE family K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 360.0
TLS2_k127_21767_9 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006721 372.0
TLS2_k127_2187339_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003693 429.0
TLS2_k127_2187339_1 ornithine cyclodeaminase K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000001026 257.0
TLS2_k127_2202652_0 Domain of unknown function (DUF4386) - - - 0.000000000000000000000000001293 118.0
TLS2_k127_2202652_1 Domain of unknown function (DUF4386) - - - 0.000000000000000000000005363 115.0
TLS2_k127_2210479_0 Creatinase/Prolidase N-terminal domain K08688 - 3.5.3.3 6.15e-197 621.0
TLS2_k127_2210479_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000003004 189.0
TLS2_k127_2210479_2 GYD domain - - - 0.0000000000000000000000000000009957 124.0
TLS2_k127_2210479_3 ABC-type transport system, periplasmic component surface lipoprotein - - - 0.00000000000001905 74.0
TLS2_k127_221149_0 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 383.0
TLS2_k127_221149_1 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 348.0
TLS2_k127_221149_2 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000000001148 154.0
TLS2_k127_221149_3 PIN domain - - - 0.0000000000000000000000000000000003913 136.0
TLS2_k127_221149_4 NifU-like N terminal domain K04488 - - 0.000000000000000000000000000000905 128.0
TLS2_k127_221149_5 ribonuclease activity - - - 0.0005231 44.0
TLS2_k127_2211830_0 ABC-type dipeptide transport system, periplasmic component K02035 - - 1.06e-201 649.0
TLS2_k127_2211830_1 Protein conserved in bacteria - - - 6.504e-197 633.0
TLS2_k127_2211830_10 PFAM helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000001216 134.0
TLS2_k127_2211830_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 467.0
TLS2_k127_2211830_3 permease K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 433.0
TLS2_k127_2211830_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 410.0
TLS2_k127_2211830_5 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005432 281.0
TLS2_k127_2211830_6 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009439 283.0
TLS2_k127_2211830_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003196 250.0
TLS2_k127_2211830_8 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000002911 195.0
TLS2_k127_2211830_9 - - - - 0.00000000000000000000000000000000000000000002707 169.0
TLS2_k127_2219018_0 Methionine synthase K00548 - 2.1.1.13 0.0 1611.0
TLS2_k127_2219018_1 Adenylate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 655.0
TLS2_k127_2219018_10 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009722 319.0
TLS2_k127_2219018_11 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 293.0
TLS2_k127_2219018_12 Bacterial periplasmic substrate-binding proteins K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001354 272.0
TLS2_k127_2219018_13 Binding-protein-dependent transport system inner membrane component K02029 - - 0.000000000000000000000000000000000000000000000000000000000000000000001518 243.0
TLS2_k127_2219018_14 (Lipo)protein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000002278 221.0
TLS2_k127_2219018_15 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.000000000000000000000000000000000000000003746 164.0
TLS2_k127_2219018_2 NAD(P)-binding Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 609.0
TLS2_k127_2219018_3 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 572.0
TLS2_k127_2219018_4 ABC transporter, ATP-binding protein K02028,K09972,K10010 - 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005556 427.0
TLS2_k127_2219018_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 391.0
TLS2_k127_2219018_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 391.0
TLS2_k127_2219018_7 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 389.0
TLS2_k127_2219018_8 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 390.0
TLS2_k127_2219018_9 Binding-protein-dependent transport system inner membrane component K02029 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 303.0
TLS2_k127_2229075_0 Pilus formation protein N terminal region K02280 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 479.0
TLS2_k127_2229075_1 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000000000000007643 205.0
TLS2_k127_2229075_2 TadE-like protein - - - 0.000000000449 68.0
TLS2_k127_2229075_3 Pilus assembly protein CpaB K02279 - - 0.0000003559 55.0
TLS2_k127_2229075_4 PFAM TadE family protein - - - 0.00009259 53.0
TLS2_k127_2261426_0 Adenylate - - - 1.573e-272 876.0
TLS2_k127_2261426_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 408.0
TLS2_k127_2261426_10 Belongs to the 'phage' integrase family - - - 0.00000000000000007723 85.0
TLS2_k127_2261426_11 Phage integrase family - - - 0.0000000000001878 80.0
TLS2_k127_2261426_2 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 361.0
TLS2_k127_2261426_3 TfuA-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 334.0
TLS2_k127_2261426_4 ammonia monooxygenase K07120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000753 280.0
TLS2_k127_2261426_5 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000002486 166.0
TLS2_k127_2261426_6 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000001184 171.0
TLS2_k127_2261426_7 viral genome integration into host DNA - - - 0.00000000000000000000000000000000000001241 157.0
TLS2_k127_2261426_8 Arm DNA-binding domain - - - 0.000000000000000000000004324 106.0
TLS2_k127_2261426_9 - - - - 0.00000000000000000000001759 107.0
TLS2_k127_2273038_0 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 484.0
TLS2_k127_2273038_1 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 363.0
TLS2_k127_2273038_2 COG0524 Sugar kinases, ribokinase family K00874 - 2.7.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007105 286.0
TLS2_k127_2273038_3 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000001308 280.0
TLS2_k127_2273038_4 Domain of unknown function (DUF4398) - - - 0.000000000000000000000000000005083 122.0
TLS2_k127_2274994_0 Belongs to the heme-copper respiratory oxidase family K02274,K15408 - 1.9.3.1 2.675e-271 852.0
TLS2_k127_2274994_1 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000002019 249.0
TLS2_k127_2274994_2 cytochrome c oxidase K02351 - - 0.0000000000000000000000000000000000000001745 169.0
TLS2_k127_2277343_0 Heat shock 70 kDa protein K04043 - - 1.469e-278 862.0
TLS2_k127_2277343_1 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 303.0
TLS2_k127_2277343_2 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007532 243.0
TLS2_k127_2277343_3 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.000000000000000000000000000000000000000000000000000000000000002279 249.0
TLS2_k127_2277343_4 flagellar protein fliS K02422 GO:0001539,GO:0003674,GO:0005198,GO:0006928,GO:0008150,GO:0009987,GO:0040011,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0097588 - 0.0000000000000003436 91.0
TLS2_k127_2284138_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1081.0
TLS2_k127_2284138_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 331.0
TLS2_k127_2284138_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000004779 231.0
TLS2_k127_2284138_3 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000005712 178.0
TLS2_k127_2284138_4 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000002419 172.0
TLS2_k127_2296667_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 4.65e-200 629.0
TLS2_k127_2296667_1 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 471.0
TLS2_k127_2296667_2 Phytanoyl-CoA dioxygenase (PhyH) K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 398.0
TLS2_k127_2296667_3 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000001919 252.0
TLS2_k127_2296667_4 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000001757 220.0
TLS2_k127_2296667_5 translation initiation inhibitor, yjgF family - - - 0.000000000000000000000000000000000000000000000000000003349 195.0
TLS2_k127_2296667_6 Domain of unknown function (DUF4437) - - - 0.000000000000000000000000000000000000000000000000005636 187.0
TLS2_k127_2296667_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000002328 98.0
TLS2_k127_2296667_8 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000000008705 86.0
TLS2_k127_2303775_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 7.287e-196 620.0
TLS2_k127_2303775_1 beta-keto acid cleavage enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009084 289.0
TLS2_k127_2303775_2 - - - - 0.00000000000000000021 97.0
TLS2_k127_230511_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 507.0
TLS2_k127_230511_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 450.0
TLS2_k127_230511_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 297.0
TLS2_k127_230511_3 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000006271 155.0
TLS2_k127_230511_4 D-galactarate dehydratase / Altronate hydrolase, C terminus K01685 - 4.2.1.7 0.0000000000000001934 84.0
TLS2_k127_230511_5 PFAM GtrA family protein - - - 0.0000004235 57.0
TLS2_k127_2314516_0 amine dehydrogenase activity - - - 3.07e-308 960.0
TLS2_k127_2314516_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009638 460.0
TLS2_k127_2314516_2 - - - - 0.0000000000000000000000000000000236 128.0
TLS2_k127_2318969_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 553.0
TLS2_k127_2326107_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K01144,K03581 - 3.1.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000893 484.0
TLS2_k127_2326107_1 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 322.0
TLS2_k127_2326107_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000002286 242.0
TLS2_k127_2326107_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000007075 158.0
TLS2_k127_2342920_0 SNF2 family N-terminal domain - - - 2.514e-258 817.0
TLS2_k127_2342920_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003406 231.0
TLS2_k127_2345653_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 435.0
TLS2_k127_2345653_1 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 417.0
TLS2_k127_2345653_10 mannose-ethanolamine phosphotransferase activity - - - 0.000000003435 69.0
TLS2_k127_2345653_11 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000004097 58.0
TLS2_k127_2345653_2 Pfam Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 412.0
TLS2_k127_2345653_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 398.0
TLS2_k127_2345653_4 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 380.0
TLS2_k127_2345653_5 Belongs to the PdxA family K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 380.0
TLS2_k127_2345653_6 Belongs to the DapA family K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008788 349.0
TLS2_k127_2345653_7 Binding-protein-dependent transport system inner membrane component K02025,K10237,K15771 GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704 - 0.000000000000000000000000000000000000000000000000000000002567 212.0
TLS2_k127_2345653_8 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000001389 216.0
TLS2_k127_2345653_9 COG0395 ABC-type sugar transport system, permease component K02026 - - 0.000000000000000000000000000000000000000000000000005935 194.0
TLS2_k127_2348120_0 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 548.0
TLS2_k127_2348120_1 PrkA AAA domain K07180 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 492.0
TLS2_k127_2348120_2 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008729 446.0
TLS2_k127_2348120_3 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000003334 135.0
TLS2_k127_2351560_0 COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 3.178e-220 701.0
TLS2_k127_2351560_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K19969 - 4.2.3.152,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 489.0
TLS2_k127_2351560_2 MgtE intracellular N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 412.0
TLS2_k127_2351560_3 Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 385.0
TLS2_k127_2351560_4 Enoyl-CoA hydratase K13766 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 289.0
TLS2_k127_2351560_5 Belongs to the peptidase S8 family K08651,K14645 - 3.4.21.66 0.000000000000000000000000000000000000000000000001768 190.0
TLS2_k127_235789_0 Uncharacterized protein family (UPF0051) K09014 - - 8.693e-263 818.0
TLS2_k127_235789_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 442.0
TLS2_k127_235789_2 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001156 279.0
TLS2_k127_235789_3 2 iron, 2 sulfur cluster binding - - - 0.0000000000000000000000000000000000000305 149.0
TLS2_k127_2358166_0 Galactose oxidase, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 456.0
TLS2_k127_2358166_1 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 291.0
TLS2_k127_2358166_2 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 283.0
TLS2_k127_2358166_3 VirC1 protein K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000001053 234.0
TLS2_k127_2358166_4 HAD-hyrolase-like K01091 - 3.1.3.18 0.00000000000000000001288 94.0
TLS2_k127_2358166_5 - - - - 0.000164 49.0
TLS2_k127_2374983_0 PFAM Integrase catalytic region K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 373.0
TLS2_k127_2374983_1 PFAM transposase IS3 IS911 family protein K07483 - - 0.00000000000000000000000000000000000339 140.0
TLS2_k127_2376179_0 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 323.0
TLS2_k127_2376179_1 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 312.0
TLS2_k127_2376179_2 ATPases associated with a variety of cellular activities K02032 - - 0.00000000000000000000000000000000000000000004814 170.0
TLS2_k127_2376179_3 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000007359 124.0
TLS2_k127_2376179_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000005198 74.0
TLS2_k127_2376179_5 Succinate dehydrogenase fumarate reductase, flavoprotein subunit K05898 - 1.3.99.4 0.000000009192 57.0
TLS2_k127_2388113_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.024e-239 755.0
TLS2_k127_2388113_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 556.0
TLS2_k127_2388113_10 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005717 374.0
TLS2_k127_2388113_11 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 375.0
TLS2_k127_2388113_12 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 334.0
TLS2_k127_2388113_13 murein endopeptidase K07261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006622 312.0
TLS2_k127_2388113_14 ATPases associated with a variety of cellular activities K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000278 300.0
TLS2_k127_2388113_15 DedA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009012 273.0
TLS2_k127_2388113_16 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004773 268.0
TLS2_k127_2388113_17 SpoU rRNA Methylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000001157 241.0
TLS2_k127_2388113_18 phosphatase homologous to the C-terminal domain of histone macroH2A1 K07114 - - 0.000000000000000000000000000000000000000000000000000019 207.0
TLS2_k127_2388113_19 Copper/zinc superoxide dismutase (SODC) K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000004055 194.0
TLS2_k127_2388113_2 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 531.0
TLS2_k127_2388113_20 Biotin biosynthesis protein BioY of Proteobacteria UniRef RepID B8F6V1_HAEPS K03523 - - 0.00000000000000000000000000000000000000000000000000117 189.0
TLS2_k127_2388113_21 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000000000000000000000512 195.0
TLS2_k127_2388113_22 phosphorelay sensor kinase activity K02660,K03406,K17763 - - 0.000000000000000000000000000000000000000000000000908 180.0
TLS2_k127_2388113_23 Etoposide-induced protein 2.4 (EI24) - - - 0.00000000000000000000000000000000000000000000001795 181.0
TLS2_k127_2388113_24 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000000000000000004996 165.0
TLS2_k127_2388113_25 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000003744 138.0
TLS2_k127_2388113_26 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000008091 131.0
TLS2_k127_2388113_27 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.00000000000000000000000000003864 120.0
TLS2_k127_2388113_28 bond formation protein, DsbB - - - 0.0000000000000000000000001306 121.0
TLS2_k127_2388113_29 Antitoxin component of a type II toxin-antitoxin (TA) system. Upon K19687 GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.00000000005155 66.0
TLS2_k127_2388113_3 Na+/Pi-cotransporter K03324 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 536.0
TLS2_k127_2388113_30 cell adhesion K02650 - - 0.00002802 55.0
TLS2_k127_2388113_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 458.0
TLS2_k127_2388113_5 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 437.0
TLS2_k127_2388113_6 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006167 432.0
TLS2_k127_2388113_7 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 400.0
TLS2_k127_2388113_8 PFAM pfkB family carbohydrate kinase K00847,K00856 - 2.7.1.20,2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 398.0
TLS2_k127_2388113_9 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 380.0
TLS2_k127_2396229_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 530.0
TLS2_k127_2396229_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 - 1.1.1.23,1.1.1.308 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 402.0
TLS2_k127_2396229_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 329.0
TLS2_k127_2396229_3 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005579 259.0
TLS2_k127_2396229_4 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001118 257.0
TLS2_k127_2396229_5 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000002831 232.0
TLS2_k127_2396229_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000002304 212.0
TLS2_k127_2396229_8 Sporulation related domain - - - 0.0000000002149 66.0
TLS2_k127_241712_0 Bacterial type II and III secretion system protein K03219 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 353.0
TLS2_k127_241712_1 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000212 202.0
TLS2_k127_241712_2 Tetratricopeptide repeat - - - 0.000000000000000000000000002441 117.0
TLS2_k127_241712_3 Secretion system effector C (SseC) like family K13285 - - 0.000000000000000000002036 110.0
TLS2_k127_241712_4 Secretion system effector C (SseC) like family - - - 0.00000000000000004331 92.0
TLS2_k127_241712_5 Tir chaperone protein (CesT) family - - - 0.00000000000008337 79.0
TLS2_k127_241712_8 - - - - 0.0001261 53.0
TLS2_k127_2417193_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006961 512.0
TLS2_k127_2417193_1 3-carboxy-cis,cis-muconate cycloisomerase K01857 - 5.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 507.0
TLS2_k127_2417193_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000001851 247.0
TLS2_k127_2417193_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000001593 209.0
TLS2_k127_241984_0 COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases K02230 - 6.6.1.2 3.123e-295 917.0
TLS2_k127_242685_0 Mycolic acid cyclopropane synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 294.0
TLS2_k127_242685_1 COG1024 Enoyl-CoA hydratase carnithine racemase - - - 0.0000000000000000000000000000000000000000000000000000000001215 206.0
TLS2_k127_2432319_0 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 458.0
TLS2_k127_2432319_1 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 332.0
TLS2_k127_2432319_2 Copper resistance protein D K07245 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007485 274.0
TLS2_k127_2432319_3 Domain of unkown function (DUF1775) - - - 0.0000000000000000000000000000000000000000000000000000000001066 211.0
TLS2_k127_2432319_4 Glutathione S-transferase N-terminal domain - - - 0.0000000000000000001031 91.0
TLS2_k127_2445774_0 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483 - 1.14.14.9 3.161e-244 764.0
TLS2_k127_2445774_1 3-oxoadipate enol-lactonase K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000006253 178.0
TLS2_k127_2448603_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 559.0
TLS2_k127_2448603_1 Protein of unknown function (DUF993) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 556.0
TLS2_k127_2448603_2 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000118 216.0
TLS2_k127_2455229_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 405.0
TLS2_k127_2455229_1 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003598 355.0
TLS2_k127_2488771_0 transposase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001132 286.0
TLS2_k127_2488771_1 COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member - - - 0.00000000000000015 82.0
TLS2_k127_2488771_2 PFAM transposase, IS4 family protein - - - 0.000000000007779 66.0
TLS2_k127_2488771_3 ISXO2-like transposase domain - - - 0.000000001356 59.0
TLS2_k127_2497696_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1268.0
TLS2_k127_2519647_0 FAD dependent oxidoreductase central domain - - - 0.0 1354.0
TLS2_k127_2519647_1 PFAM peptidase S15 K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 397.0
TLS2_k127_2519647_2 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000008967 76.0
TLS2_k127_2519647_3 Ribbon-helix-helix protein, copG family - - - 0.0000001167 60.0
TLS2_k127_2519647_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0004274 52.0
TLS2_k127_2540492_0 N-terminal half of MaoC dehydratase K17865 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016043,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0042620,GO:0042621,GO:0043933,GO:0044085,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576 4.2.1.55 0.000000000000000000000000000000000000000000000000000000005626 202.0
TLS2_k127_2540492_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000002111 188.0
TLS2_k127_2541577_0 PFAM tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 469.0
TLS2_k127_2541577_1 Uncharacterized protein conserved in bacteria (DUF2333) - - - 0.00000000000000000000000000000000000000001404 164.0
TLS2_k127_256834_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11779,K11784 - 1.21.98.1,2.5.1.77 0.0 1047.0
TLS2_k127_256834_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000322 242.0
TLS2_k127_256834_2 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000004403 109.0
TLS2_k127_2571649_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 2.559e-269 842.0
TLS2_k127_2571649_1 protein related to plant photosystem II stability assembly factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008938 606.0
TLS2_k127_2571649_10 - - - - 0.0000000000000000000000000000000009045 132.0
TLS2_k127_2571649_11 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000004152 58.0
TLS2_k127_2571649_2 Bacterial protein of unknown function (DUF899) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 336.0
TLS2_k127_2571649_3 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 308.0
TLS2_k127_2571649_4 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000839 268.0
TLS2_k127_2571649_5 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.0000000000000000000000000000000000000000000000000000000000000001067 223.0
TLS2_k127_2571649_6 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000000003595 226.0
TLS2_k127_2571649_7 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000000000000000000000000000007364 206.0
TLS2_k127_2571649_8 Aminotransferase K14261 - - 0.00000000000000000000000000000000000000000005858 162.0
TLS2_k127_2571649_9 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000000000000000000000009372 138.0
TLS2_k127_2579357_0 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 544.0
TLS2_k127_2579357_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07306,K07309,K07310,K08351 - 1.8.5.3,1.97.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000601 271.0
TLS2_k127_2604554_0 Adenylate and Guanylate cyclase catalytic domain - - - 1.902e-218 715.0
TLS2_k127_2604554_1 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 620.0
TLS2_k127_2604554_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 546.0
TLS2_k127_262402_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 4.101e-226 712.0
TLS2_k127_262402_1 cobalamin biosynthesis protein CobW K02234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008059 443.0
TLS2_k127_262402_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 368.0
TLS2_k127_262402_3 Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate K02231 - 2.7.1.156,2.7.7.62 0.00000000000000000000000000000000000000000000000000001843 194.0
TLS2_k127_262402_4 CobN/Magnesium Chelatase K02230 - 6.6.1.2 0.00000003681 56.0
TLS2_k127_268409_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 5.115e-215 683.0
TLS2_k127_268409_1 Bacterial extracellular solute-binding protein K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 430.0
TLS2_k127_268409_10 Lysylphosphatidylglycerol synthase TM region - - - 0.0000000000000001391 93.0
TLS2_k127_268409_11 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000004589 64.0
TLS2_k127_268409_12 Plasmid stability protein - - - 0.000842 46.0
TLS2_k127_268409_2 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 412.0
TLS2_k127_268409_3 PFAM binding-protein-dependent transport systems inner membrane component K02025,K10118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009975 394.0
TLS2_k127_268409_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 373.0
TLS2_k127_268409_5 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 346.0
TLS2_k127_268409_6 ABC-type sugar transport system, permease component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004317 345.0
TLS2_k127_268409_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008378,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 344.0
TLS2_k127_268409_8 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000001172 221.0
TLS2_k127_268409_9 PFAM PIN domain - - - 0.000000000000000000000002898 106.0
TLS2_k127_2713508_0 PFAM Integrase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008175 404.0
TLS2_k127_2713508_1 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000009513 149.0
TLS2_k127_2713508_2 Evidence 4 Homologs of previously reported genes of K07483 - - 0.00000001143 61.0
TLS2_k127_2728897_0 PFAM short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 357.0
TLS2_k127_2728897_1 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007025 280.0
TLS2_k127_2728897_2 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009405 288.0
TLS2_k127_2728897_3 COG0593 ATPase involved in DNA replication initiation - - - 0.0000000000000000000000000000000000000000000000000000000000001725 234.0
TLS2_k127_2728897_4 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000000000001049 159.0
TLS2_k127_2728897_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000002774 139.0
TLS2_k127_2759032_0 Adenylate cyclase K01768 - 4.6.1.1 2.275e-280 872.0
TLS2_k127_2759032_1 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components K15598 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 423.0
TLS2_k127_2759032_2 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K15599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 296.0
TLS2_k127_2759032_3 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000004864 140.0
TLS2_k127_2759032_4 Ferredoxin K04755 - - 0.00000000000000000000000000000000006037 136.0
TLS2_k127_2759032_5 tRNA methyl transferase K00566 - 2.8.1.13 0.000000000000000000000005635 113.0
TLS2_k127_2759074_0 Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005831 356.0
TLS2_k127_2759074_1 Protein of unknown function (DUF3604) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000576 268.0
TLS2_k127_2759074_2 long-chain fatty acid transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000005934 237.0
TLS2_k127_2759074_3 carbonate dehydratase activity K01674 - 4.2.1.1 0.000000000000000000000000000000000000000000001882 176.0
TLS2_k127_2759074_4 Las17-binding protein actin regulator - - - 0.000000000000000000000000000000000139 141.0
TLS2_k127_2759074_5 - - - - 0.00000000002798 75.0
TLS2_k127_2769603_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 422.0
TLS2_k127_2769603_1 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000008152 211.0
TLS2_k127_2769603_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000004334 88.0
TLS2_k127_2771789_0 TRAP transporter, 4TM 12TM fusion protein - - - 8.213e-288 898.0
TLS2_k127_2771789_1 Belongs to the arginase family K01479,K01480,K12255 - 3.5.3.11,3.5.3.7,3.5.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 525.0
TLS2_k127_2771789_2 TRAP transporter, solute receptor (TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 427.0
TLS2_k127_2771789_3 COG1176 ABC-type spermidine putrescine transport system permease component I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004669 401.0
TLS2_k127_2771789_4 ABC-type spermidine putrescine transport system, permease component II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 389.0
TLS2_k127_2771789_5 PFAM extracellular solute-binding protein family 1 K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 284.0
TLS2_k127_280498_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004854 269.0
TLS2_k127_280498_1 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000009954 261.0
TLS2_k127_280498_2 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.0000002775 53.0
TLS2_k127_2807716_0 COG2133 Glucose sorbosone dehydrogenases - - - 2.084e-205 651.0
TLS2_k127_2807716_1 Aminotransferase class I and II - - - 0.0000000000000000000000000000000000000000000000000000002475 198.0
TLS2_k127_2807716_2 Cytochrome C oxidase, cbb3-type, subunit III K16255 - - 0.0000000000000000000000000000000000000000004093 164.0
TLS2_k127_2807716_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000005686 130.0
TLS2_k127_2811911_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 578.0
TLS2_k127_2811911_1 amidohydrolase K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 505.0
TLS2_k127_2811911_2 AFG1-like ATPase K06916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 363.0
TLS2_k127_2815052_0 Belongs to the UbiD family K03182 - 4.1.1.98 3.501e-272 854.0
TLS2_k127_2815052_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 383.0
TLS2_k127_2815052_2 PFAM extracellular solute-binding protein family 1 K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 308.0
TLS2_k127_2815052_3 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000001176 233.0
TLS2_k127_2815052_4 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000001315 222.0
TLS2_k127_2815052_5 ubiE/COQ5 methyltransferase family K00570 - 2.1.1.17,2.1.1.71 0.00000000000000000000000000000000000000000001182 182.0
TLS2_k127_2815543_0 Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3' - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 325.0
TLS2_k127_2823332_0 Domain of unknown function (DUF3463) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 289.0
TLS2_k127_2823332_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004732 272.0
TLS2_k127_2823332_2 Phosphorylase superfamily K01243 - 3.2.2.9 0.0000000000000000000000000000000000000000004404 167.0
TLS2_k127_2836369_0 ABC transporter substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 432.0
TLS2_k127_2836369_1 TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 437.0
TLS2_k127_2836369_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008844 313.0
TLS2_k127_2836369_3 Sulphur oxidation protein SoxZ K17226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000113 273.0
TLS2_k127_2836369_4 - - - - 0.0000000000000000000000000000000000002699 151.0
TLS2_k127_2836369_5 - - - - 0.0000000000000000000000000002129 119.0
TLS2_k127_2836369_6 Protein of unknown function (DUF2380) - - - 0.00000000000000851 79.0
TLS2_k127_2837891_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000005864 250.0
TLS2_k127_2837891_1 - - - - 0.000000000000000006385 90.0
TLS2_k127_2845301_0 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 5.171e-250 784.0
TLS2_k127_2845301_1 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007786 613.0
TLS2_k127_2845301_10 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008281 302.0
TLS2_k127_2845301_11 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003097 287.0
TLS2_k127_2845301_12 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001107 267.0
TLS2_k127_2845301_13 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000001079 224.0
TLS2_k127_2845301_14 Belongs to the RbsD FucU family K02431 - 5.1.3.29 0.0000000000000000000000000000000000000000000000000000000000000007221 222.0
TLS2_k127_2845301_15 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.0000000000000000000000000000000000000000003099 162.0
TLS2_k127_2845301_16 Transcription elongation factor, GreA/GreB, C-term K06140 - - 0.00000000000000000000000001038 115.0
TLS2_k127_2845301_17 - - - - 0.00000000004635 68.0
TLS2_k127_2845301_18 Fggy-family pentulose kinase K00875 GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019150,GO:0019200,GO:0019321,GO:0019725,GO:0042592,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0060249,GO:0065007,GO:0065008,GO:0070050,GO:0071704 2.7.1.47 0.000000003694 61.0
TLS2_k127_2845301_19 - - - - 0.00002599 55.0
TLS2_k127_2845301_2 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 541.0
TLS2_k127_2845301_3 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 529.0
TLS2_k127_2845301_4 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 381.0
TLS2_k127_2845301_5 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006934 353.0
TLS2_k127_2845301_6 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 347.0
TLS2_k127_2845301_7 Predicted permease YjgP/YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 318.0
TLS2_k127_2845301_8 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 292.0
TLS2_k127_2845301_9 PPIC-type PPIASE domain K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 309.0
TLS2_k127_2850867_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.143e-258 807.0
TLS2_k127_2850867_1 Cys/Met metabolism PLP-dependent enzyme K01738,K01740 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 7.164e-200 631.0
TLS2_k127_2850867_2 C4-dicarboxylate ABC transporter permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006801 552.0
TLS2_k127_2850867_3 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001768 480.0
TLS2_k127_2850867_4 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000235 325.0
TLS2_k127_2850867_5 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003215 263.0
TLS2_k127_2850867_6 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000009441 235.0
TLS2_k127_2850867_7 Tripartite tricarboxylate transporter TctB family - - - 0.000000000002998 73.0
TLS2_k127_2853995_0 Amidase K02433 - 6.3.5.6,6.3.5.7 6.017e-212 669.0
TLS2_k127_2853995_1 oxidoreductase K18652 - 1.1.1.361 0.0000000000000000000000000000000000000001008 154.0
TLS2_k127_2853995_2 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000003726 112.0
TLS2_k127_2860151_0 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009021 376.0
TLS2_k127_2860151_1 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 357.0
TLS2_k127_2860151_2 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007151 306.0
TLS2_k127_2860151_3 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009067 246.0
TLS2_k127_2860151_4 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000002544 236.0
TLS2_k127_2862579_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 4.644e-220 694.0
TLS2_k127_2862579_1 Dehydrogenase E1 component K21416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 428.0
TLS2_k127_2862579_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 336.0
TLS2_k127_2862579_3 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K21417 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 302.0
TLS2_k127_2862579_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002275 243.0
TLS2_k127_2875861_0 PFAM Type II secretion system protein E K02454 - - 2.258e-197 643.0
TLS2_k127_2875861_1 Glutamate-cysteine ligase family 2(GCS2) K06048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 436.0
TLS2_k127_2875861_2 Type II secretion system K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 303.0
TLS2_k127_2875861_3 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002216 252.0
TLS2_k127_2875861_4 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000001929 208.0
TLS2_k127_2875861_5 Protein of unknown function (DUF1244) K09948 - - 0.00000000000000000000000005773 107.0
TLS2_k127_2879517_0 Transposase DDE domain K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 547.0
TLS2_k127_2879517_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000002847 210.0
TLS2_k127_2883683_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 3.328e-301 942.0
TLS2_k127_2883683_1 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 1.582e-216 686.0
TLS2_k127_2883683_10 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002336 289.0
TLS2_k127_2883683_11 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000002606 226.0
TLS2_k127_2883683_12 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000001516 182.0
TLS2_k127_2883683_13 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000005925 72.0
TLS2_k127_2883683_14 alpha/beta hydrolase fold - - - 0.000006308 52.0
TLS2_k127_2883683_2 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 1.865e-213 668.0
TLS2_k127_2883683_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 569.0
TLS2_k127_2883683_4 Protein of unknown function - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 451.0
TLS2_k127_2883683_5 GguC protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 413.0
TLS2_k127_2883683_6 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 366.0
TLS2_k127_2883683_7 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 341.0
TLS2_k127_2883683_8 X-Pro dipeptidyl-peptidase (S15 family) K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009763 334.0
TLS2_k127_2883683_9 serine acetyltransferase K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002672 274.0
TLS2_k127_2886145_0 Belongs to the ABC transporter superfamily K13896 - - 2.042e-232 731.0
TLS2_k127_2886145_1 transport system, permease component K13895 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003693 551.0
TLS2_k127_2886145_10 MerR, DNA binding K13639 - - 0.000000000000000000000000000000000000000000000000000000000000000001882 229.0
TLS2_k127_2886145_11 reductase K05895 - 1.3.1.106,1.3.1.54 0.00000000000000000000000000000000000000000000000000000000000000003539 237.0
TLS2_k127_2886145_12 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000005548 223.0
TLS2_k127_2886145_14 COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.00000000000003421 83.0
TLS2_k127_2886145_15 Metallo-beta-lactamase superfamily - - - 0.00005571 47.0
TLS2_k127_2886145_2 COG4175 ABC-type proline glycine betaine transport system ATPase component K02000 GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 506.0
TLS2_k127_2886145_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004393 480.0
TLS2_k127_2886145_4 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 451.0
TLS2_k127_2886145_5 Binding-protein-dependent transport system inner membrane component K02001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000756 394.0
TLS2_k127_2886145_6 Short chain dehydrogenase reductase family oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 313.0
TLS2_k127_2886145_7 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 306.0
TLS2_k127_2886145_8 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001985 287.0
TLS2_k127_2886145_9 transport system, permease component K13894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001791 269.0
TLS2_k127_2886387_0 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 358.0
TLS2_k127_2886387_1 Binding-protein-dependent transport system inner membrane component K11071 - - 0.000000000000000000000000000000000000000000003119 164.0
TLS2_k127_2886387_2 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000002692 160.0
TLS2_k127_2886387_3 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.0000000000000000003501 96.0
TLS2_k127_2887355_0 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers K07518 - 3.1.1.22 1.994e-225 712.0
TLS2_k127_2887355_1 alpha-glucosidase K01187 - 3.2.1.20 5.352e-220 694.0
TLS2_k127_2887355_10 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000147 268.0
TLS2_k127_2887355_11 Methylene-tetrahydrofolate reductase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000004768 210.0
TLS2_k127_2887355_12 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000005395 192.0
TLS2_k127_2887355_14 Domain of unknown function DUF29 - - - 0.000000000000000000000000004422 130.0
TLS2_k127_2887355_15 COG0665 Glycine D-amino acid oxidases (deaminating) - - - 0.000000000000000000000000827 105.0
TLS2_k127_2887355_16 Domain of unknown function DUF29 - - - 0.000000000000000000000001145 111.0
TLS2_k127_2887355_17 - - - - 0.00000000000001308 78.0
TLS2_k127_2887355_18 - - - - 0.0000000000001558 78.0
TLS2_k127_2887355_2 COG2873 O-acetylhomoserine sulfhydrylase - - - 1.439e-211 665.0
TLS2_k127_2887355_3 FAD dependent oxidoreductase - - - 1.792e-205 647.0
TLS2_k127_2887355_4 Methylenetetrahydrofolate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 512.0
TLS2_k127_2887355_5 FAD binding domain K00103 - 1.1.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 497.0
TLS2_k127_2887355_6 ATPase component of ABC-type sugar transporter K10111 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 443.0
TLS2_k127_2887355_7 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 362.0
TLS2_k127_2887355_8 Enoyl-(Acyl carrier protein) reductase K08261,K21620 - 1.1.1.16,1.1.99.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 312.0
TLS2_k127_2887355_9 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001104 295.0
TLS2_k127_2887465_0 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0 1381.0
TLS2_k127_2887465_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 3.311e-194 616.0
TLS2_k127_2887465_10 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000009083 132.0
TLS2_k127_2887465_11 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000006128 121.0
TLS2_k127_2887465_13 Tir chaperone protein (CesT) family - - - 0.0003713 50.0
TLS2_k127_2887465_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 5.263e-194 612.0
TLS2_k127_2887465_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 482.0
TLS2_k127_2887465_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 478.0
TLS2_k127_2887465_5 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004312 481.0
TLS2_k127_2887465_6 PFAM Response regulator receiver domain K15012 GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000001298 253.0
TLS2_k127_2887465_7 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000005002 242.0
TLS2_k127_2887465_9 - - - - 0.00000000000000000000000000000000000000000002329 172.0
TLS2_k127_2888190_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 576.0
TLS2_k127_2888190_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 385.0
TLS2_k127_2888190_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001658 274.0
TLS2_k127_2888190_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000009092 252.0
TLS2_k127_2888190_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000000000000000002891 109.0
TLS2_k127_2888190_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000001962 90.0
TLS2_k127_289108_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 377.0
TLS2_k127_289108_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005498 291.0
TLS2_k127_289108_2 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000000003088 225.0
TLS2_k127_289108_3 Putative peptidoglycan binding domain - - - 0.000000001376 63.0
TLS2_k127_2900166_0 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 588.0
TLS2_k127_2900166_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 454.0
TLS2_k127_2900166_2 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005513 295.0
TLS2_k127_2900166_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000008475 262.0
TLS2_k127_2900166_4 Lipopolysaccharide-assembly K03643 - - 0.00000000000000000000000000000000003705 139.0
TLS2_k127_2901463_0 Aldehyde dehydrogenase family K00128,K22187 - 1.2.1.3 3.033e-229 719.0
TLS2_k127_2901463_1 Mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 361.0
TLS2_k127_2901463_2 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 304.0
TLS2_k127_2902031_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 598.0
TLS2_k127_2902031_1 Phage portal protein lambda family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 355.0
TLS2_k127_2902031_10 Phage portal protein lambda family - - - 0.000000000222 62.0
TLS2_k127_2902031_2 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 339.0
TLS2_k127_2902031_3 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 301.0
TLS2_k127_2902031_4 PLD-like domain - - - 0.000000000000000000000000000000000000000000000000000000001625 212.0
TLS2_k127_2902031_5 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000001165 200.0
TLS2_k127_2902031_6 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000004537 173.0
TLS2_k127_2902031_8 ChaB K06197 - - 0.000000000000000000001048 100.0
TLS2_k127_2902031_9 PFAM PEBP family protein K06910 - - 0.00000000005706 64.0
TLS2_k127_2903043_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.663e-274 871.0
TLS2_k127_2903043_1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000687 529.0
TLS2_k127_2903043_2 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 442.0
TLS2_k127_2903043_3 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 337.0
TLS2_k127_2903043_4 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000006124 236.0
TLS2_k127_2903043_5 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000002689 174.0
TLS2_k127_2903043_6 Bacterial protein of unknown function (DUF839) K07093 - - 0.0000000000000000000000000000000000000000002989 164.0
TLS2_k127_2903043_7 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000006072 154.0
TLS2_k127_2903043_8 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.0000000000127 74.0
TLS2_k127_2903774_0 Protein conserved in bacteria K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 436.0
TLS2_k127_2903774_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 338.0
TLS2_k127_2903774_2 SpoU rRNA Methylase family K03437 - - 0.00000000000000000000000000000000000000000000000000000000000000002322 231.0
TLS2_k127_2906372_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1521.0
TLS2_k127_2906372_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 2.709e-204 649.0
TLS2_k127_2906372_10 Molecular chaperone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001302 265.0
TLS2_k127_2906372_11 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000821 247.0
TLS2_k127_2906372_12 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901576 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000001673 207.0
TLS2_k127_2906372_13 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000000000000000000252 180.0
TLS2_k127_2906372_14 Protein phosphatase 2C - - - 0.000000000000000000000000000000000000000000000008088 180.0
TLS2_k127_2906372_15 Virulence factor BrkB K07058 - - 0.0000000000000000000000000000000000000000000001973 179.0
TLS2_k127_2906372_16 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000001483 162.0
TLS2_k127_2906372_17 Histidine kinase-like ATPase domain - - - 0.0000000000000000000000000004328 119.0
TLS2_k127_2906372_18 Alginate biosynthesis protein Alg44 - - - 0.00000000000000000000002661 106.0
TLS2_k127_2906372_19 - - - - 0.000000002859 66.0
TLS2_k127_2906372_2 mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K00971,K01809,K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006335 470.0
TLS2_k127_2906372_20 HIRAN domain - - - 0.0000000797 61.0
TLS2_k127_2906372_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 452.0
TLS2_k127_2906372_4 Trypsin K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 419.0
TLS2_k127_2906372_5 COG0708 Exonuclease III K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 356.0
TLS2_k127_2906372_6 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 341.0
TLS2_k127_2906372_7 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 333.0
TLS2_k127_2906372_8 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 307.0
TLS2_k127_2906372_9 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000002297 271.0
TLS2_k127_2909012_0 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003257 282.0
TLS2_k127_2909012_1 Putative transposase of IS4/5 family (DUF4096) - - - 0.0000000000000000000000000000000000000000000000000000000000004569 214.0
TLS2_k127_2909012_2 Transposase DDE domain - - - 0.0000000000000001415 88.0
TLS2_k127_2916405_0 COG0747 ABC-type dipeptide transport system, periplasmic component K02035 - - 6.839e-243 763.0
TLS2_k127_2916405_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 400.0
TLS2_k127_2916405_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 391.0
TLS2_k127_2916405_3 Diacylglycerol kinase catalytic domain (presumed) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002248 286.0
TLS2_k127_2916405_4 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000008523 192.0
TLS2_k127_2916405_5 - - - - 0.000001283 56.0
TLS2_k127_2916405_6 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000005658 49.0
TLS2_k127_2920065_0 Aminotransferase class-III K15785 - 2.6.1.76 1.85e-205 649.0
TLS2_k127_2920065_1 Carbamoyltransferase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 585.0
TLS2_k127_2920065_10 FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.000000000000000001559 88.0
TLS2_k127_2920065_11 Rv0623-like transcription factor K19687 GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.000000000000002389 79.0
TLS2_k127_2920065_12 Exopolysaccharide synthesis ExoD - - - 0.00000009437 57.0
TLS2_k127_2920065_2 Acetoacetyl-CoA reductase K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 414.0
TLS2_k127_2920065_3 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 391.0
TLS2_k127_2920065_4 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001609 274.0
TLS2_k127_2920065_5 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001925 259.0
TLS2_k127_2920065_6 PFAM Integrase core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000167 253.0
TLS2_k127_2920065_7 cyclopropane-fatty-acyl-phospholipid synthase - - - 0.000000000000000000000000000000000000000001138 165.0
TLS2_k127_2920065_8 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - 0.0000000000000000000000000000000000000002241 167.0
TLS2_k127_2920065_9 Toxic component of a toxin-antitoxin (TA) module. An RNase K19686 - - 0.000000000000000000000000000000006238 132.0
TLS2_k127_2922559_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 592.0
TLS2_k127_2922559_1 Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP K00868 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008478,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.7.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000001492 273.0
TLS2_k127_2927675_0 Dihydrodipicolinate synthetase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 493.0
TLS2_k127_2927675_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000002249 101.0
TLS2_k127_2927675_2 Tripartite tricarboxylate transporter TctB family - - - 0.0000000001055 65.0
TLS2_k127_2930278_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.9e-287 887.0
TLS2_k127_2930278_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009595 571.0
TLS2_k127_2930278_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 341.0
TLS2_k127_2936111_0 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000002257 250.0
TLS2_k127_2936111_1 Single Cache domain 2 K02480 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000001038 229.0
TLS2_k127_2936111_2 Peptidase C39 family - - - 0.0000000000000000000000000000000000000000000000000000001889 212.0
TLS2_k127_2936111_3 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000005655 171.0
TLS2_k127_2936111_4 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000001088 135.0
TLS2_k127_2936111_5 regulator - - - 0.0000000000000000000000000000002836 133.0
TLS2_k127_2936111_6 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000004167 96.0
TLS2_k127_2936111_7 by Glimmer2 - - - 0.000000002654 68.0
TLS2_k127_2936886_0 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 2.651e-204 651.0
TLS2_k127_2936886_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003028 561.0
TLS2_k127_2936886_10 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 297.0
TLS2_k127_2936886_11 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 310.0
TLS2_k127_2936886_12 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002185 280.0
TLS2_k127_2936886_13 Protein of unknown function (DUF1013) K09987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002828 274.0
TLS2_k127_2936886_14 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000003317 261.0
TLS2_k127_2936886_15 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000567 244.0
TLS2_k127_2936886_16 NIPSNAP family containing protein - - - 0.0000000000000000000000000000000000000000002862 161.0
TLS2_k127_2936886_17 Phosphatase - - - 0.000000000000000000000000000000000000001857 155.0
TLS2_k127_2936886_18 Usg-like family - - - 0.000000000000000000000000000003459 125.0
TLS2_k127_2936886_19 Protein of unknown function (DUF3299) K09950 - - 0.0000000000000000000000005294 113.0
TLS2_k127_2936886_2 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008803 418.0
TLS2_k127_2936886_20 domain, Protein - - - 0.0000000000000000000002447 105.0
TLS2_k127_2936886_22 - - - - 0.0002451 48.0
TLS2_k127_2936886_3 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 430.0
TLS2_k127_2936886_4 Belongs to the ABC transporter superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 431.0
TLS2_k127_2936886_5 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006033 417.0
TLS2_k127_2936886_6 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 420.0
TLS2_k127_2936886_7 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007778 389.0
TLS2_k127_2936886_8 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 351.0
TLS2_k127_2936886_9 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004509 322.0
TLS2_k127_2937623_0 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006444 372.0
TLS2_k127_2937623_1 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 331.0
TLS2_k127_2937623_10 5-formyltetrahydrofolate cyclo-ligase family - - - 0.0000000000000000000000000000000000000000000412 166.0
TLS2_k127_2937623_11 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000426 155.0
TLS2_k127_2937623_12 Predicted integral membrane protein (DUF2282) - - - 0.0000000000000000000000001151 108.0
TLS2_k127_2937623_13 Domain of unknown function DUF302 - - - 0.00000000000000000000002136 103.0
TLS2_k127_2937623_14 Protein of unknown function, DUF417 - - - 0.0000000000000000003724 94.0
TLS2_k127_2937623_15 - - - - 0.000000000000000001305 94.0
TLS2_k127_2937623_16 Domain of unknown function DUF302 - - - 0.00000000007836 68.0
TLS2_k127_2937623_17 5-formyltetrahydrofolate cyclo-ligase family - - - 0.000000001313 68.0
TLS2_k127_2937623_2 UPF0126 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004582 282.0
TLS2_k127_2937623_3 Sigma-70, region 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000103 265.0
TLS2_k127_2937623_4 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001529 247.0
TLS2_k127_2937623_5 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000005207 231.0
TLS2_k127_2937623_6 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000000000000000000000000000000000000000000000000001532 208.0
TLS2_k127_2937623_7 COG2217 Cation transport ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000006096 211.0
TLS2_k127_2937623_8 - - - - 0.000000000000000000000000000000000000000000001164 169.0
TLS2_k127_2937623_9 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000004898 166.0
TLS2_k127_2944718_0 Bacterial extracellular solute-binding protein K02027 - - 6.718e-215 678.0
TLS2_k127_2944718_1 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000711 451.0
TLS2_k127_2944718_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007369 299.0
TLS2_k127_2944718_3 - - - - 0.000000000000000000008143 96.0
TLS2_k127_2945694_0 Adenylate - - - 0.0 1063.0
TLS2_k127_2954251_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 1.23e-256 818.0
TLS2_k127_2954251_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 1.628e-253 791.0
TLS2_k127_2954251_2 Belongs to the GMC oxidoreductase family - - - 2.181e-230 725.0
TLS2_k127_2954251_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 628.0
TLS2_k127_2954251_4 Amidase K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007199 529.0
TLS2_k127_2954251_5 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006854 284.0
TLS2_k127_2954251_6 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007549 254.0
TLS2_k127_2955409_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 9.893e-287 891.0
TLS2_k127_2955409_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 548.0
TLS2_k127_2955409_2 PFAM Cys Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 488.0
TLS2_k127_2955409_3 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 400.0
TLS2_k127_2955409_4 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000001684 239.0
TLS2_k127_2955409_5 Domain of unknown function (DUF4383) - - - 0.0000000000000000000000000000000000000000000000005714 180.0
TLS2_k127_2955409_6 Putative restriction endonuclease - - - 0.0000000000000000008015 92.0
TLS2_k127_2955409_7 COG0457 FOG TPR repeat - - - 0.0000000000000008714 89.0
TLS2_k127_2955702_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072,K11076 - 3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 404.0
TLS2_k127_2955702_1 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 331.0
TLS2_k127_2955702_2 COG2199 FOG GGDEF domain K13590 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000025 231.0
TLS2_k127_2955702_3 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000003211 188.0
TLS2_k127_2958120_0 NADH flavin oxidoreductase NADH oxidase K21833 - - 3.552e-278 867.0
TLS2_k127_2958120_1 biosynthesis protein E K06139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 482.0
TLS2_k127_2958120_10 Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide - - - 0.0007442 43.0
TLS2_k127_2958120_2 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 370.0
TLS2_k127_2958120_3 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009934 356.0
TLS2_k127_2958120_4 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005752 247.0
TLS2_k127_2958120_5 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000001074 138.0
TLS2_k127_2958120_6 peptidyl-tyrosine modification K06138 - - 0.000000000000000000003182 106.0
TLS2_k127_2958120_7 COG0457 FOG TPR repeat - - - 0.000000000000000003824 91.0
TLS2_k127_2958120_8 Uncharacterized conserved protein (DUF2190) - - - 0.0001569 48.0
TLS2_k127_2958120_9 SnoaL-like domain - - - 0.0006911 42.0
TLS2_k127_2962640_0 MULE transposase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000631 219.0
TLS2_k127_2962640_1 Phage shock protein A - - - 0.000004871 58.0
TLS2_k127_2963785_0 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 553.0
TLS2_k127_2963785_1 Endonuclease I K01150 - 3.1.21.1 0.000000000000000000000000000000000000000000000000000000000000000000002279 244.0
TLS2_k127_2963785_2 PFAM Glycoside hydrolase family 65, central catalytic - - - 0.000000000000000000000000000000000000000000000003755 193.0
TLS2_k127_2963785_3 Domain of unknown function (DUF4926) - - - 0.00001324 51.0
TLS2_k127_2963785_4 domain, Protein - - - 0.00002315 47.0
TLS2_k127_2972604_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 4.43e-279 868.0
TLS2_k127_2972604_1 Dehydrogenase K18369 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 564.0
TLS2_k127_2972604_10 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009796 281.0
TLS2_k127_2972604_11 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000001307 243.0
TLS2_k127_2972604_12 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.00000000000000000000000000000000000000000000000000000001687 218.0
TLS2_k127_2972604_13 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000297 197.0
TLS2_k127_2972604_14 ChrR Cupin-like domain - - - 0.000000000000000000000000000000000000000000000000002649 184.0
TLS2_k127_2972604_15 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000000000000000000000002819 187.0
TLS2_k127_2972604_16 ApaG domain K06195 - - 0.0000000000000000000000000000000000000000000000005185 177.0
TLS2_k127_2972604_17 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000000000000000000000000000000000008061 157.0
TLS2_k127_2972604_18 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.00000000000000000000000000000000000000005794 158.0
TLS2_k127_2972604_19 - - - - 0.0000000000000000000000000000000000000001356 168.0
TLS2_k127_2972604_2 MBOAT, membrane-bound O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 558.0
TLS2_k127_2972604_20 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000155 162.0
TLS2_k127_2972604_21 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000355 135.0
TLS2_k127_2972604_22 Putative restriction endonuclease - - - 0.000000000000000000000000000007062 126.0
TLS2_k127_2972604_23 - - - - 0.00000000000000000000000000001009 131.0
TLS2_k127_2972604_24 Protein of unknown function (DUF3775) - - - 0.0000000000000000000000000003242 124.0
TLS2_k127_2972604_25 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000001219 130.0
TLS2_k127_2972604_26 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000006911 116.0
TLS2_k127_2972604_27 Staphylococcal nuclease homologue - - - 0.00000000000000000000002062 108.0
TLS2_k127_2972604_28 Proteolipid membrane potential modulator - - - 0.00000000000000000000005336 100.0
TLS2_k127_2972604_29 Protein of unknown function (FYDLN_acid) - - - 0.0000000000000000001915 98.0
TLS2_k127_2972604_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 541.0
TLS2_k127_2972604_30 Lipopolysaccharide assembly protein A domain K08992 - - 0.000000000000001099 81.0
TLS2_k127_2972604_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 531.0
TLS2_k127_2972604_5 COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006422 477.0
TLS2_k127_2972604_6 Alcohol dehydrogenase GroES-like domain K00001 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 390.0
TLS2_k127_2972604_7 amino acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008016 355.0
TLS2_k127_2972604_8 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 340.0
TLS2_k127_2972604_9 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 317.0
TLS2_k127_2977254_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.665e-261 818.0
TLS2_k127_2977254_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004782 384.0
TLS2_k127_2977254_10 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000001857 235.0
TLS2_k127_2977254_11 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000009194 217.0
TLS2_k127_2977254_12 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000007113 223.0
TLS2_k127_2977254_13 Glycosyl transferase family group 2 K16556 - - 0.00000000000000000000000000000000000000000000000000000007814 212.0
TLS2_k127_2977254_14 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000001593 198.0
TLS2_k127_2977254_15 Protein of unknown function (DUF3105) - - - 0.0000000000000000000000000000000000000000000000001331 184.0
TLS2_k127_2977254_16 Belongs to the Fur family K09826 - - 0.0000000000000000000000000000000000000000000000007781 179.0
TLS2_k127_2977254_17 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000002025 190.0
TLS2_k127_2977254_18 TspO/MBR family - - - 0.000000000000000000000000000000000000000000005353 180.0
TLS2_k127_2977254_19 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.0000000000000000000000000000819 130.0
TLS2_k127_2977254_2 Bacterial sugar transferase K00996,K16566 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 344.0
TLS2_k127_2977254_20 Glycosyl transferase family 2 - - - 0.00000000000000000000000361 113.0
TLS2_k127_2977254_21 O-Antigen ligase K16567 - - 0.00000000000000000000002263 114.0
TLS2_k127_2977254_22 - - - - 0.0000002574 57.0
TLS2_k127_2977254_3 PFAM lipopolysaccharide biosynthesis protein K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 353.0
TLS2_k127_2977254_4 transferase activity, transferring glycosyl groups K16558 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 323.0
TLS2_k127_2977254_5 glycosyl transferase - GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 322.0
TLS2_k127_2977254_6 Xylose isomerase-like TIM barrel K18910 - 5.1.3.30,5.1.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 296.0
TLS2_k127_2977254_7 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001725 265.0
TLS2_k127_2977254_8 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000004324 245.0
TLS2_k127_2977254_9 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.00000000000000000000000000000000000000000000000000000000000000000038 247.0
TLS2_k127_2994358_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 9.943e-276 853.0
TLS2_k127_2994358_1 Glucose dehydrogenase C-terminus - - - 5.94e-207 649.0
TLS2_k127_2994358_10 PFAM Alpha beta hydrolase fold-3 domain protein K01066 - - 0.00000002771 59.0
TLS2_k127_2994358_2 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 435.0
TLS2_k127_2994358_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009432 253.0
TLS2_k127_2994358_4 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.000000000000000000000000000000000000000004037 159.0
TLS2_k127_2994358_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.00000000000000000000000000000000000000003873 156.0
TLS2_k127_2994358_6 domain protein K01179,K01342,K01406,K07004,K12287,K14194,K15125,K20276 - 3.2.1.4,3.4.21.62,3.4.24.40 0.0000000000000000000000000000004823 132.0
TLS2_k127_2994358_7 Rhodanese domain protein - - - 0.000000000000000000000000000001113 131.0
TLS2_k127_2994358_8 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000009525 85.0
TLS2_k127_2994358_9 toxin-antitoxin pair type II binding - - - 0.0000000000002254 79.0
TLS2_k127_2996554_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008889 324.0
TLS2_k127_2996554_1 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006965 276.0
TLS2_k127_2996554_2 Belongs to the precorrin methyltransferase family K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000128 256.0
TLS2_k127_2996554_3 helix_turn_helix ASNC type K05800 - - 0.00000000000000000000000000000000000000000000000000000000000000327 234.0
TLS2_k127_2996554_4 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component K00380 - 1.8.1.2 0.00000000000000000000000000000000000000000000000000006574 191.0
TLS2_k127_3009459_0 Beta-eliminating lyase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 407.0
TLS2_k127_3009459_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 379.0
TLS2_k127_3009459_2 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 358.0
TLS2_k127_3009459_3 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000005762 200.0
TLS2_k127_3009459_4 succinate dehydrogenase fumarate reductase, flavoprotein subunit - - - 0.000000000000000000000000000000000000000000006349 165.0
TLS2_k127_3014636_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 3.426e-197 624.0
TLS2_k127_3014636_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 524.0
TLS2_k127_3014636_10 Protein of unknown function (DUF3299) K09950 - - 0.00000000000000000000000006816 113.0
TLS2_k127_3014636_11 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.000000000000000004608 87.0
TLS2_k127_3014636_12 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000003885 76.0
TLS2_k127_3014636_2 Competence protein K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 522.0
TLS2_k127_3014636_3 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009235 453.0
TLS2_k127_3014636_4 Enoyl-(Acyl carrier protein) reductase K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 340.0
TLS2_k127_3014636_5 3-beta hydroxysteroid dehydrogenase/isomerase family K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 303.0
TLS2_k127_3014636_6 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 298.0
TLS2_k127_3014636_7 TraT complement resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000001469 237.0
TLS2_k127_3014636_8 Phytoene squalene synthetase K02291 - 2.5.1.32,2.5.1.99 0.000000000000000000000000000000000000000000001448 175.0
TLS2_k127_3014636_9 PilT protein domain protein - - - 0.0000000000000000000000000000000003443 136.0
TLS2_k127_3036925_0 PFAM extracellular solute-binding protein, family 3 K16254 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 286.0
TLS2_k127_3036925_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000003741 279.0
TLS2_k127_3036925_2 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000000000000000000000000000000000001124 184.0
TLS2_k127_3043420_0 GTP-binding protein TypA K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 9.778e-283 882.0
TLS2_k127_3043420_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.00000000000000000000000000000000000000000000000000000000008604 205.0
TLS2_k127_3043420_2 - - - - 0.000000000000000000000000000000000000000000000000000003709 197.0
TLS2_k127_3043420_3 Protein of unknown function (DUF1194) - - - 0.0000000000001761 74.0
TLS2_k127_3044840_0 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 310.0
TLS2_k127_3044840_1 - - - - 0.0000000000000000000000000000000000005874 156.0
TLS2_k127_304849_0 Methyltransferase K14083 - 2.1.1.250 8.181e-200 635.0
TLS2_k127_304849_1 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006927 556.0
TLS2_k127_304849_10 - - - - 0.00000000001153 70.0
TLS2_k127_304849_2 Sel1 domain protein repeat-containing protein K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 542.0
TLS2_k127_304849_3 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 387.0
TLS2_k127_304849_4 NAD(P)H-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000001241 229.0
TLS2_k127_304849_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000002991 210.0
TLS2_k127_304849_6 Acyl-CoA dehydrogenase, middle domain K00252 - 1.3.8.6 0.0000000000000000000000000000000000001473 153.0
TLS2_k127_304849_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000007132 145.0
TLS2_k127_304849_8 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.000000000000000000000000000008732 129.0
TLS2_k127_3053047_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 514.0
TLS2_k127_3053047_1 PFAM Glucose Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 494.0
TLS2_k127_3053047_2 COG0433 Predicted ATPase K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 323.0
TLS2_k127_3053047_3 COG1910, Periplasmic molybdate-binding protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 320.0
TLS2_k127_3053047_4 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000002576 220.0
TLS2_k127_3053047_5 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000001516 195.0
TLS2_k127_3053047_6 Domain of unknown function DUF29 - - - 0.00000000000000000000000001563 115.0
TLS2_k127_3063687_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 370.0
TLS2_k127_3063687_1 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003349 286.0
TLS2_k127_3063687_2 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000002394 219.0
TLS2_k127_3063687_4 - - - - 0.0000000000004941 79.0
TLS2_k127_3063687_5 - - - - 0.0000000003122 70.0
TLS2_k127_3065005_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 6.251e-287 899.0
TLS2_k127_3065005_1 COG4664 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 1.882e-223 707.0
TLS2_k127_3065005_10 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004402 249.0
TLS2_k127_3065005_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000004104 232.0
TLS2_k127_3065005_2 acyl-CoA transferases carnitine dehydratase K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 569.0
TLS2_k127_3065005_3 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007524 471.0
TLS2_k127_3065005_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 464.0
TLS2_k127_3065005_5 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 411.0
TLS2_k127_3065005_6 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 344.0
TLS2_k127_3065005_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 323.0
TLS2_k127_3065005_8 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 297.0
TLS2_k127_3065005_9 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004216 250.0
TLS2_k127_3067301_0 Acetamidase/Formamidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 479.0
TLS2_k127_3067301_1 Carbohydrate ABC transporter membrane protein 2, CUT1 family K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001143 261.0
TLS2_k127_3067301_2 Binding-protein-dependent transport system inner membrane component K02025,K10118 - - 0.000000000000000000000000000000000000000000000000000000000000009011 229.0
TLS2_k127_3067301_3 carbohydrate transport - - - 0.000000000000000000000000000000000000000000007215 179.0
TLS2_k127_3067301_4 FCD - - - 0.00000000000000000000000000000000000000000004501 171.0
TLS2_k127_3067301_5 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000001815 91.0
TLS2_k127_3079881_0 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007081 424.0
TLS2_k127_3079881_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 309.0
TLS2_k127_3079881_2 Amino acid synthesis - - - 0.0000000000000000000000000000000000000000000000000005506 192.0
TLS2_k127_3082429_0 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 4.011e-218 683.0
TLS2_k127_3082429_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.682e-205 646.0
TLS2_k127_3082429_10 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000001181 217.0
TLS2_k127_3082429_11 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.000000000000000000000000000000000000000000000000001929 194.0
TLS2_k127_3082429_12 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000000000000000001051 199.0
TLS2_k127_3082429_13 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000001426 182.0
TLS2_k127_3082429_14 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0000000000000000000000000000000000000000000000002428 179.0
TLS2_k127_3082429_15 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000000000000002814 179.0
TLS2_k127_3082429_16 thioesterase K07107 - - 0.000000000000000000000000000000000000000003605 160.0
TLS2_k127_3082429_17 Cell division and transport-associated protein TolA - - - 0.0000000000000000000000000000003035 136.0
TLS2_k127_3082429_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 580.0
TLS2_k127_3082429_3 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 552.0
TLS2_k127_3082429_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 495.0
TLS2_k127_3082429_5 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 356.0
TLS2_k127_3082429_6 TIGRFAM DNA-binding regulatory protein, YebC PmpR family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 339.0
TLS2_k127_3082429_7 PFAM MotA TolQ ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 300.0
TLS2_k127_3082429_8 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000007014 263.0
TLS2_k127_3082429_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000001958 231.0
TLS2_k127_3087253_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 6.986e-263 818.0
TLS2_k127_3087253_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 5.015e-244 776.0
TLS2_k127_3087253_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009863 426.0
TLS2_k127_3087253_3 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 352.0
TLS2_k127_3087253_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001765 254.0
TLS2_k127_3087253_5 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008692 224.0
TLS2_k127_3087253_6 protein involved in outer membrane biogenesis - - - 0.000000000000000000000000000000000000000000000000000000000000009802 246.0
TLS2_k127_3087253_7 - - - - 0.000000000000000000004185 104.0
TLS2_k127_3096427_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 474.0
TLS2_k127_3096427_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007327 459.0
TLS2_k127_3096427_10 Cytochrome P460 - - - 0.000000000000000000000000000000002036 145.0
TLS2_k127_3096427_11 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.0000000000000000000000003522 113.0
TLS2_k127_3096427_12 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000001281 66.0
TLS2_k127_3096427_13 Protein of unknown function (DUF3179) - - - 0.0000000000429 66.0
TLS2_k127_3096427_2 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 445.0
TLS2_k127_3096427_3 Peptidase dimerisation domain K01438 - 3.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 422.0
TLS2_k127_3096427_4 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 406.0
TLS2_k127_3096427_5 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 351.0
TLS2_k127_3096427_6 May be involved in the biosynthesis of molybdopterin K03638 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0042802,GO:0044424,GO:0044444,GO:0044464 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 282.0
TLS2_k127_3096427_7 rRNA (guanine-N2-)-methyltransferase activity K15257 - - 0.00000000000000000000000000000000000000000000000000000006623 210.0
TLS2_k127_3096427_8 - - - - 0.000000000000000000000000000000000000000000003997 168.0
TLS2_k127_3096427_9 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000000000000000000000000001928 157.0
TLS2_k127_3099109_0 Di- and tricarboxylate transporters - - - 9.949e-198 627.0
TLS2_k127_3099109_1 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 434.0
TLS2_k127_3099109_2 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 415.0
TLS2_k127_3099109_3 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 299.0
TLS2_k127_3099109_4 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004703 286.0
TLS2_k127_3099109_5 Maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000737 272.0
TLS2_k127_3099109_6 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000001124 213.0
TLS2_k127_3099109_7 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000001193 214.0
TLS2_k127_3110718_0 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005825 617.0
TLS2_k127_3110718_1 COG1175 ABC-type sugar transport systems permease components K02025,K10237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 447.0
TLS2_k127_3110718_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 383.0
TLS2_k127_3110718_3 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000398 344.0
TLS2_k127_3110718_4 Thioesterase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002921 280.0
TLS2_k127_3110718_5 Binding-protein-dependent transport system inner membrane component K02026,K10238 - - 0.00000000000000004905 82.0
TLS2_k127_31189_0 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 436.0
TLS2_k127_31189_1 Belongs to the enoyl-CoA hydratase isomerase family K01692,K11264 - 4.1.1.41,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 334.0
TLS2_k127_313835_0 permease K07086 - - 0.00000000000000000000000000000000000000000000000000000000000000004387 229.0
TLS2_k127_313835_1 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000000000000002318 133.0
TLS2_k127_313835_2 Cro/C1-type HTH DNA-binding domain - - - 0.00000000000000000000008478 102.0
TLS2_k127_3153014_0 Belongs to the amidase family K01426 - 3.5.1.4 1.726e-262 815.0
TLS2_k127_3153014_1 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 424.0
TLS2_k127_3153014_2 Branched-chain amino acid ATP-binding cassette transporter K01995,K11962 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 359.0
TLS2_k127_3153014_3 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005061 295.0
TLS2_k127_3153014_4 DNA invertase Pin - - - 0.0000000000000000000000000003997 115.0
TLS2_k127_3163578_0 - - - - 0.00000000000000000000000000000000000000352 159.0
TLS2_k127_3163578_1 Sulfatase K01133 - 3.1.6.6 0.00000006724 56.0
TLS2_k127_3163578_2 - - - - 0.0000005218 58.0
TLS2_k127_3168867_0 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 349.0
TLS2_k127_3168867_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.000000000000000002882 90.0
TLS2_k127_3177982_0 Involved in initiation control of chromosome replication K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 498.0
TLS2_k127_3177982_1 PFAM transposase IS4 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 478.0
TLS2_k127_3177982_2 Transposase zinc-ribbon domain - - - 0.000000000000000000000000000000000000000000000000000000008346 204.0
TLS2_k127_3177982_3 Involved in initiation control of chromosome replication K07484 - - 0.00000000000000000000000000000000003099 153.0
TLS2_k127_319460_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.081e-288 904.0
TLS2_k127_319460_1 Sigma-54 interaction domain K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 543.0
TLS2_k127_319460_10 Flagellar hook-length control protein FliK - - - 0.0000000000000000002977 98.0
TLS2_k127_319460_11 Flagellar assembly protein FliH K02411 - - 0.0000000000000002583 88.0
TLS2_k127_319460_2 Flagellar basal body protein FlaE K02390 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 476.0
TLS2_k127_319460_3 The M ring may be actively involved in energy transduction K02409 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 450.0
TLS2_k127_319460_4 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 415.0
TLS2_k127_319460_5 Flagellar GTP-binding protein K02404 - - 0.00000000000000000000000000000000000000000000000000000007573 207.0
TLS2_k127_319460_6 Belongs to the ParA family K04562 - - 0.00000000000000000000000000000000002246 149.0
TLS2_k127_319460_7 Protein of unknown function (DUF1153) - - - 0.0000000000000000000000000000000001255 136.0
TLS2_k127_319460_8 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0000000000000000000000000000000001846 141.0
TLS2_k127_319460_9 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 GO:0005575,GO:0005623,GO:0005886,GO:0009288,GO:0009425,GO:0016020,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0071944 - 0.00000000000000000000000000000006808 130.0
TLS2_k127_3198824_0 DALR_2 K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 403.0
TLS2_k127_3198824_1 Steryl acetyl hydrolase K19561 - 3.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003885 277.0
TLS2_k127_3198824_2 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000000000000000000000017 179.0
TLS2_k127_3218680_0 the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE K09013 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 336.0
TLS2_k127_3218680_1 FeS assembly protein SufD K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001068 299.0
TLS2_k127_3218680_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000003465 210.0
TLS2_k127_3219039_0 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 599.0
TLS2_k127_3219039_1 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 323.0
TLS2_k127_3219039_2 Domain of unknown function DUF29 - - - 0.000000000000000000000000000643 119.0
TLS2_k127_3219039_3 Domain of unknown function DUF29 - - - 0.000000000000000000000000224 111.0
TLS2_k127_3222599_0 PFAM Alcohol dehydrogenase - - - 1.23e-207 652.0
TLS2_k127_3222599_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 310.0
TLS2_k127_3222599_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004705 283.0
TLS2_k127_3222599_3 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.0000000000000000000000000000000000000000000000000000000002266 212.0
TLS2_k127_3222599_4 Flagellar biosynthetic protein FliR K02421 - - 0.0000000000000000000000000000000000000000000000000002316 194.0
TLS2_k127_3222599_5 Flagellar basal body rod FlgEFG protein C-terminal K02388 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.000000000000000000000000000000000000000000000471 172.0
TLS2_k127_3222599_6 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.0000000000000000000000000001168 120.0
TLS2_k127_3222599_7 Role in flagellar biosynthesis K02420 - - 0.000000000000000000598 101.0
TLS2_k127_3222599_8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.00000000000000006384 83.0
TLS2_k127_3222599_9 Flagellar hook-basal body K02408 - - 0.0000000000000007507 81.0
TLS2_k127_3222747_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 503.0
TLS2_k127_3222747_1 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000156 150.0
TLS2_k127_3223382_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 555.0
TLS2_k127_3223382_1 gluconolactonase K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 382.0
TLS2_k127_3223382_2 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002219 266.0
TLS2_k127_3223382_3 Maltose acetyltransferase K00661 - 2.3.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000377 265.0
TLS2_k127_3223382_4 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000007313 183.0
TLS2_k127_3223382_5 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000003819 158.0
TLS2_k127_3223382_6 Tautomerase enzyme K01821 - 5.3.2.6 0.00000000001455 72.0
TLS2_k127_3223382_7 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.00000000414 64.0
TLS2_k127_3235776_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 381.0
TLS2_k127_3235776_1 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 344.0
TLS2_k127_3235776_2 COGs COG1653 ABC-type sugar transport system periplasmic component K02027 - - 0.00000000004635 68.0
TLS2_k127_3237107_0 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 451.0
TLS2_k127_3237107_1 Plasmid stability protein K21495 - - 0.00009527 48.0
TLS2_k127_3238459_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 392.0
TLS2_k127_3238459_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000000000000000000000000000000000005558 216.0
TLS2_k127_3238459_2 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000000000000000000000000009296 119.0
TLS2_k127_3238459_3 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000001613 101.0
TLS2_k127_3242845_0 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 1.183e-224 715.0
TLS2_k127_3242845_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 480.0
TLS2_k127_3242845_2 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 417.0
TLS2_k127_3245266_0 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 1.906e-201 632.0
TLS2_k127_3245266_1 ABC transporter K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003019 262.0
TLS2_k127_3245266_2 Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates K01426,K01455,K18540 - 3.5.1.100,3.5.1.4,3.5.1.49 0.000000000000000000000000000000000000000000000000001556 186.0
TLS2_k127_3245266_3 RES - - - 0.00000000000000000000000000000000000000008388 156.0
TLS2_k127_3245266_4 Protein of unknown function (DUF2384) - - - 0.000000000000000000000000000008599 122.0
TLS2_k127_324769_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1275.0
TLS2_k127_324769_1 COG4166 ABC-type oligopeptide transport system, periplasmic component K13893 - - 4.379e-245 786.0
TLS2_k127_324769_2 Binding-protein-dependent transport system inner membrane component K13894 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 562.0
TLS2_k127_324769_3 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 365.0
TLS2_k127_324769_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 319.0
TLS2_k127_324769_5 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 310.0
TLS2_k127_324769_6 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001111 263.0
TLS2_k127_324769_7 COG3474 Cytochrome c2 K08738 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005713 253.0
TLS2_k127_324769_8 ligase activity - - - 0.0000000000000000000000000000007314 130.0
TLS2_k127_324769_9 RQC K03654 - 3.6.4.12 0.00000000000000000000000009625 113.0
TLS2_k127_3248850_0 PrpF protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008413 542.0
TLS2_k127_3248850_1 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 370.0
TLS2_k127_3248850_2 Tripartite tricarboxylate transporter TctA family - - - 0.00000000000000000000000001744 115.0
TLS2_k127_3260291_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 541.0
TLS2_k127_3260291_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003402 505.0
TLS2_k127_3260291_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 436.0
TLS2_k127_3260291_3 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 357.0
TLS2_k127_3260291_4 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 317.0
TLS2_k127_3260291_5 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001937 302.0
TLS2_k127_3260323_0 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 374.0
TLS2_k127_3260323_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000003547 163.0
TLS2_k127_3260323_2 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000000000000000000003986 141.0
TLS2_k127_3260323_3 Adenylate - - - 0.000000000000000002371 86.0
TLS2_k127_3260323_4 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000005931 76.0
TLS2_k127_3260323_5 Tetratricopeptide repeat - - - 0.000001232 50.0
TLS2_k127_3260323_6 Adenylate and Guanylate cyclase catalytic domain - - - 0.0001621 46.0
TLS2_k127_3260323_7 PAS fold K01768 - 4.6.1.1 0.0009444 49.0
TLS2_k127_3260963_0 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000846 436.0
TLS2_k127_3260963_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 364.0
TLS2_k127_3260963_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000002186 226.0
TLS2_k127_3260963_3 esterase lipase - - - 0.000000000000000000000000000000000000009083 161.0
TLS2_k127_3263039_0 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002771 276.0
TLS2_k127_3263039_1 ABC transporter K01990,K09689,K09691 - 3.6.3.38 0.0000000000000000000000000000000000000000000000000000000000006224 230.0
TLS2_k127_3263039_2 capsule polysaccharide export system inner membrane protein K10107 - - 0.000000000000000000000000000000000000000000000000000000000001411 224.0
TLS2_k127_3263039_3 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000111 210.0
TLS2_k127_3263039_4 ABC-2 type transporter K09688 - - 0.000000000000000000000000000000000000000000000007459 186.0
TLS2_k127_3263039_5 17 kDa common-antigen outer membrane protein - - - 0.0004561 52.0
TLS2_k127_3283804_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 5.584e-252 795.0
TLS2_k127_3283804_1 transport system periplasmic component K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000001146 225.0
TLS2_k127_3283804_2 Glutathione S-transferase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000003805 186.0
TLS2_k127_3287201_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 1.25e-280 870.0
TLS2_k127_3287201_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 3.42e-219 693.0
TLS2_k127_3287201_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K16066 - 1.1.1.381 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001782 280.0
TLS2_k127_3287201_3 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase K01625 - 4.1.2.14,4.1.3.42 0.00000000000000000000000000000000000000000000000000000000000000000000009014 262.0
TLS2_k127_3287201_4 Haem-degrading - - - 0.000000000000000000000000000000000000000000000000000000000000002387 236.0
TLS2_k127_3287201_5 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000002377 204.0
TLS2_k127_329053_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18989 - - 0.0 1200.0
TLS2_k127_329053_1 Protein conserved in bacteria K09983 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 312.0
TLS2_k127_329053_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001411 290.0
TLS2_k127_329053_3 OsmC-like protein K04063 - - 0.0000000000000000000000000000000000000000000006791 169.0
TLS2_k127_329053_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000001236 159.0
TLS2_k127_329053_5 Transcriptional regulator PadR-like family - - - 0.000000000000000000000000000000000000001628 154.0
TLS2_k127_329053_6 Cation antiporter K05569 - - 0.0000000000000000000000000000001818 129.0
TLS2_k127_329053_7 Domain of unknown function (DUF2383) - - - 0.00000000000006224 78.0
TLS2_k127_329053_8 - - - - 0.0000000004351 64.0
TLS2_k127_329053_9 Bile acid sodium symporter - - - 0.00000002972 57.0
TLS2_k127_3306250_0 Belongs to the GcvT family K00302 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.3.1 0.0 1147.0
TLS2_k127_3306250_1 ABC transporter transmembrane region K06147,K18890 - - 5.673e-253 796.0
TLS2_k127_3306250_10 Domain of unknown function DUF29 - - - 0.000000000000005467 81.0
TLS2_k127_3306250_2 ABC-type multidrug transport system ATPase and permease K06147 - - 5.492e-228 721.0
TLS2_k127_3306250_3 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 602.0
TLS2_k127_3306250_4 Sarcosine oxidase, delta subunit family K00304 - 1.5.3.1 0.00000000000000000000000000000000000000003887 158.0
TLS2_k127_3306250_5 Sarcosine oxidase, gamma subunit K00305 - 1.5.3.1 0.0000000000000000000000000000000000001588 149.0
TLS2_k127_3306250_6 Domain of unknown function DUF29 - - - 0.0000000000000000000000000006956 118.0
TLS2_k127_3306250_7 InterPro IPR007367 - - - 0.0000000000000000000000006442 110.0
TLS2_k127_3306250_8 protein involved in - - - 0.0000000000000000000000119 107.0
TLS2_k127_3306250_9 Domain of unknown function DUF29 - - - 0.00000000000000000000002513 111.0
TLS2_k127_3306927_0 Amidase K02433 - 6.3.5.6,6.3.5.7 5.639e-200 638.0
TLS2_k127_3306927_1 Bacterial extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 529.0
TLS2_k127_3306927_2 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 425.0
TLS2_k127_3306927_3 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007953 411.0
TLS2_k127_3306927_4 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000008927 191.0
TLS2_k127_3306927_5 Lysylphosphatidylglycerol synthase TM region - - - 0.0000000000000000000000000000000000000000000000000001981 200.0
TLS2_k127_3306927_6 Transcriptional regulator - - - 0.0000000000000000000000000001301 126.0
TLS2_k127_3306927_7 PFAM HupE UreJ protein K03192 - - 0.0000000000000000000001212 100.0
TLS2_k127_3314539_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1071.0
TLS2_k127_3314539_1 COG0513 Superfamily II DNA and RNA helicases K17675 - 3.6.4.13 1.217e-267 848.0
TLS2_k127_3314539_2 Cupin superfamily protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 318.0
TLS2_k127_3314539_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002519 280.0
TLS2_k127_3314539_4 Domain of unknown function (DUF3576) - - - 0.000000000000000000000000000000000000000141 156.0
TLS2_k127_3314539_5 Molecular chaperone. Has ATPase activity K04079 - - 0.000000000000000000000000000000000006671 139.0
TLS2_k127_3314539_6 Gram-negative porin K08720 - - 0.0000000000000000000000000007493 126.0
TLS2_k127_3314539_7 S4 domain K04762 - - 0.000000000000000000000000003157 119.0
TLS2_k127_332063_0 Catalase K07217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 431.0
TLS2_k127_332063_1 CHAT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 450.0
TLS2_k127_332063_2 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 320.0
TLS2_k127_332063_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003022 265.0
TLS2_k127_3321579_0 Glutaminyl-tRNA synthetase K01886 - 6.1.1.18 5.163e-249 783.0
TLS2_k127_3321579_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 606.0
TLS2_k127_3321579_10 Cytochrome b/b6/petB K12262 - - 0.000000000000000000000000000000000000000000001769 172.0
TLS2_k127_3321579_11 nuclease - - - 0.00000000000000000000000000000006416 134.0
TLS2_k127_3321579_12 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000005673 114.0
TLS2_k127_3321579_13 PFAM FecR protein - - - 0.0000000000000000004217 97.0
TLS2_k127_3321579_14 PFAM pentapeptide repeat protein - - - 0.0000000000000001095 92.0
TLS2_k127_3321579_15 transferase activity, transferring glycosyl groups - - - 0.0000000000000002633 92.0
TLS2_k127_3321579_16 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.000001239 52.0
TLS2_k127_3321579_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 469.0
TLS2_k127_3321579_3 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003998 435.0
TLS2_k127_3321579_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007549 409.0
TLS2_k127_3321579_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 391.0
TLS2_k127_3321579_6 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 393.0
TLS2_k127_3321579_7 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791,K13019 - 5.1.3.14,5.1.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 351.0
TLS2_k127_3321579_8 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 293.0
TLS2_k127_3321579_9 Glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000004757 250.0
TLS2_k127_3371911_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 8.996e-218 682.0
TLS2_k127_3371911_1 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 598.0
TLS2_k127_3371911_10 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000002301 222.0
TLS2_k127_3371911_11 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000000003053 215.0
TLS2_k127_3371911_12 COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000004617 229.0
TLS2_k127_3371911_13 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001452 211.0
TLS2_k127_3371911_14 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000279 208.0
TLS2_k127_3371911_15 Hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000008325 217.0
TLS2_k127_3371911_16 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000000004257 191.0
TLS2_k127_3371911_17 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000008666 186.0
TLS2_k127_3371911_18 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000002774 184.0
TLS2_k127_3371911_19 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000000000959 162.0
TLS2_k127_3371911_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 565.0
TLS2_k127_3371911_20 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000002075 153.0
TLS2_k127_3371911_21 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000000000000002158 135.0
TLS2_k127_3371911_22 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000002568 129.0
TLS2_k127_3371911_23 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000001047 102.0
TLS2_k127_3371911_24 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000002706 93.0
TLS2_k127_3371911_25 Ribosomal protein L30p/L7e K02907 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000004777 85.0
TLS2_k127_3371911_3 PFAM aldo keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 533.0
TLS2_k127_3371911_4 Belongs to the peptidase S1C family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 450.0
TLS2_k127_3371911_5 Responsible for synthesis of pseudouridine from uracil K06179 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 346.0
TLS2_k127_3371911_6 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 313.0
TLS2_k127_3371911_7 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 281.0
TLS2_k127_3371911_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006543 284.0
TLS2_k127_3371911_9 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002037 259.0
TLS2_k127_3389723_0 PFAM alpha amylase, catalytic K05343 GO:0000023,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0005991,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009311,GO:0009987,GO:0015980,GO:0016160,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0046872,GO:0047471,GO:0055114,GO:0071704 3.2.1.1,5.4.99.16 1.662e-220 690.0
TLS2_k127_3389723_1 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006347 374.0
TLS2_k127_3389723_2 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001,K19745 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005397 364.0
TLS2_k127_3389723_3 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002241 249.0
TLS2_k127_3389723_4 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000002458 134.0
TLS2_k127_3389723_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000172 64.0
TLS2_k127_3403831_0 Fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 515.0
TLS2_k127_3403831_1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers K07518 - 3.1.1.22 0.0000000000000000000000000000004394 134.0
TLS2_k127_3403831_2 Cytochrome c K08738 - - 0.00000000000006631 82.0
TLS2_k127_3403831_3 Belongs to the 'phage' integrase family - - - 0.0001147 45.0
TLS2_k127_3416543_0 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 355.0
TLS2_k127_3416543_1 S4 RNA-binding domain K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 325.0
TLS2_k127_3416543_2 Plays a role in the flagellum-specific transport system K02419 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 312.0
TLS2_k127_3416543_3 trisaccharide binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 341.0
TLS2_k127_3416543_4 membrane - - - 0.000000000000000000000000000000000000000000000000004924 190.0
TLS2_k127_3416543_5 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000009587 175.0
TLS2_k127_3416543_6 Protein of unknown function (DUF2905) - - - 0.000000000000000000000006676 104.0
TLS2_k127_3416543_7 Flagellar biosynthesis protein, FliO - - - 0.000000000000007886 81.0
TLS2_k127_3416543_8 Protein of unknown function (DUF2905) - - - 0.0000000006754 64.0
TLS2_k127_3416543_9 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.00004328 51.0
TLS2_k127_3428722_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 2.156e-271 841.0
TLS2_k127_3428722_1 TatD related DNase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 541.0
TLS2_k127_3428722_10 Domain of unknown function (DUF4168) - - - 0.00003763 52.0
TLS2_k127_3428722_2 mandelate racemase muconate lactonizing - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009745 529.0
TLS2_k127_3428722_3 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 363.0
TLS2_k127_3428722_4 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 347.0
TLS2_k127_3428722_5 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001236 266.0
TLS2_k127_3428722_6 Domain of unknown function (DUF1932) - - - 0.00000000000000000000000000000000000000000000000000000000000000000004147 244.0
TLS2_k127_3428722_8 IG-like fold at C-terminal of FixG, putative oxidoreductase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000006293 64.0
TLS2_k127_3428722_9 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.000000006599 58.0
TLS2_k127_3440709_0 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000007146 261.0
TLS2_k127_3440709_1 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000001096 196.0
TLS2_k127_3440709_2 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000005108 183.0
TLS2_k127_3440709_3 YbaK prolyl-tRNA synthetase associated - - - 0.000000000000000000000000000000000000000000000001119 179.0
TLS2_k127_3440709_4 - - - - 0.0000000000000000000000000000000000000000001083 167.0
TLS2_k127_3440709_5 Cytochrome c - - - 0.0000000000000000000000000000000000000000007132 164.0
TLS2_k127_3440709_6 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000002348 163.0
TLS2_k127_3440709_7 PFAM Cupin 2 conserved barrel domain protein K21700 - - 0.0000000000000000000000000000000000231 136.0
TLS2_k127_3440709_8 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000000000003422 105.0
TLS2_k127_3440709_9 - - - - 0.00000000000000007315 90.0
TLS2_k127_344591_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1074.0
TLS2_k127_344591_1 Glycine D-amino acid oxidase (deaminating) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 428.0
TLS2_k127_344591_2 cyclopropane-fatty-acyl-phospholipid synthase K00574,K07154,K14369,K15257,K18534 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0016999,GO:0017000,GO:0017144,GO:0032259,GO:0044237,GO:0044249 2.1.1.254,2.1.1.295,2.1.1.79,2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 393.0
TLS2_k127_344591_3 permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000054 259.0
TLS2_k127_344591_4 Laminin G domain K01406 - 3.4.24.40 0.0000000000000000000000000000000000000000004287 183.0
TLS2_k127_344591_5 Laminin G domain - - - 0.00000000000000000000000000000000000006199 166.0
TLS2_k127_344591_6 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.00000000000000002249 84.0
TLS2_k127_3450622_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 3.635e-194 619.0
TLS2_k127_3450622_1 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 419.0
TLS2_k127_3450622_2 SOS response K14160 - - 0.000000000000000000000000002748 116.0
TLS2_k127_3452131_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006271 387.0
TLS2_k127_3452131_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001989 271.0
TLS2_k127_3452131_2 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000005492 184.0
TLS2_k127_3472825_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005686 390.0
TLS2_k127_3472825_1 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K21395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 362.0
TLS2_k127_3472825_2 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000779 162.0
TLS2_k127_3511548_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01847 - 5.4.99.2 0.0 1017.0
TLS2_k127_3511548_1 PFAM regulatory protein LysR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 368.0
TLS2_k127_3511548_2 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007743 336.0
TLS2_k127_3511548_3 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 317.0
TLS2_k127_3511548_4 Glycosyl transferase family 1 - - - 0.0000000000000000000000000000000000000000000000001686 190.0
TLS2_k127_3511548_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000000000000000000000003811 152.0
TLS2_k127_3511548_6 HupE / UreJ protein K03192 - - 0.0000000000000000000000000405 112.0
TLS2_k127_3511548_7 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000931 74.0
TLS2_k127_3521000_0 beta-keto acid cleavage enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 505.0
TLS2_k127_3521000_1 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 478.0
TLS2_k127_3521000_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002054 252.0
TLS2_k127_3521000_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000001452 216.0
TLS2_k127_353338_0 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009668 402.0
TLS2_k127_353338_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000003894 200.0
TLS2_k127_3533824_0 Periplasmic binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 522.0
TLS2_k127_3533824_1 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 457.0
TLS2_k127_3533824_2 ABC transporter substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004251 369.0
TLS2_k127_3533824_3 - - - - 0.000000000000000000000000000000000000000000000000000000000009958 213.0
TLS2_k127_3533824_4 Cytochrome c mono- and diheme variants - - - 0.0000000000000000000001235 98.0
TLS2_k127_359303_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006545 488.0
TLS2_k127_359303_1 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.000000000000000000000000000000000006671 139.0
TLS2_k127_359303_2 - - - - 0.000000000000009541 80.0
TLS2_k127_35989_0 Alpha amylase, catalytic domain K06044 - 5.4.99.15 1.329e-201 643.0
TLS2_k127_35989_1 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 0.00003186 46.0
TLS2_k127_360277_0 Acyl-CoA dehydrogenase N terminal K00248 - 1.3.8.1 1.991e-194 636.0
TLS2_k127_360277_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 290.0
TLS2_k127_360277_2 Pentapeptide repeats (9 copies) - - - 0.000000000000000000000000000000000000000009982 169.0
TLS2_k127_360277_3 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000002106 76.0
TLS2_k127_360277_6 Protein of unknown function (DUF3108) - - - 0.000005319 59.0
TLS2_k127_3609364_0 Protein of unknown function (DUF2848) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001137 258.0
TLS2_k127_3609364_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000006667 117.0
TLS2_k127_3620098_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.256e-204 651.0
TLS2_k127_3620098_1 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 326.0
TLS2_k127_3620098_2 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000001425 88.0
TLS2_k127_363467_0 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000002234 193.0
TLS2_k127_363467_1 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000000000000000000000000000000000000005277 181.0
TLS2_k127_363467_2 Phosphoglycerate mutase family - - - 0.00000000000000000000000000002542 119.0
TLS2_k127_3652178_0 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 382.0
TLS2_k127_3652178_1 Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002669 331.0
TLS2_k127_3652178_2 ATP-dependent protease La (LON) substrate-binding domain K01338,K07157 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000007385 249.0
TLS2_k127_3652178_3 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000003821 252.0
TLS2_k127_3652178_4 Protein of unknown function (DUF971) - - - 0.0000000000000000000000000000000000000001309 154.0
TLS2_k127_3652178_5 Belongs to the UPF0434 family K09791 - - 0.00000000000000000000006774 101.0
TLS2_k127_3652178_6 PFAM response regulator receiver - - - 0.000000000000000000003681 98.0
TLS2_k127_3652178_7 - - - - 0.000003312 54.0
TLS2_k127_366384_0 Protein of unknown function (DUF3500) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001619 269.0
TLS2_k127_366384_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004506 251.0
TLS2_k127_366384_2 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000000000008939 154.0
TLS2_k127_366384_3 TIR domain K10297 - - 0.000000000000000000000000000000000006938 142.0
TLS2_k127_366384_4 Domain of unknown function DUF29 - - - 0.00000000000000000000000000000000456 143.0
TLS2_k127_366384_5 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000002929 129.0
TLS2_k127_366384_6 Rhodanese Homology Domain - - - 0.000000000000000000000000008162 114.0
TLS2_k127_366384_7 Domain of unknown function (DUF4332) - - - 0.00000000000000000000638 101.0
TLS2_k127_3676844_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 458.0
TLS2_k127_3676844_1 membrane component K02034 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000002908 179.0
TLS2_k127_3676844_2 PIN domain - - - 0.000000000000000000000000000000000001762 145.0
TLS2_k127_3676844_3 - - - - 0.0000002343 56.0
TLS2_k127_3703858_0 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 431.0
TLS2_k127_3703858_1 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001703 290.0
TLS2_k127_3703858_2 ABC transporter K02049 - - 0.0000000000000000000000000000000000001098 143.0
TLS2_k127_3744436_0 Type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006484 478.0
TLS2_k127_3744436_1 COG COG1653 ABC-type sugar transport system periplasmic component Carbohydrate transport and metabolism K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005215 257.0
TLS2_k127_3744436_10 Type II secretion system (T2SS), protein M subtype b K02462 - - 0.0000008604 62.0
TLS2_k127_3744436_11 TadE-like protein - - - 0.0001228 54.0
TLS2_k127_3744436_2 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000000000000000118 179.0
TLS2_k127_3744436_3 Type II secretion system (T2SS), protein K K02460 - - 0.00000000000000000000000000000000004182 148.0
TLS2_k127_3744436_4 general secretion pathway protein K02461 - - 0.0000000000000000000000000000000004448 145.0
TLS2_k127_3744436_5 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000192 120.0
TLS2_k127_3744436_6 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000005486 130.0
TLS2_k127_3744436_7 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000001074 80.0
TLS2_k127_3744436_8 HupE / UreJ protein - - - 0.00000000008254 74.0
TLS2_k127_3744436_9 - - - - 0.0000001373 60.0
TLS2_k127_3748793_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007325 301.0
TLS2_k127_3748793_1 Dicarboxylate transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002887 279.0
TLS2_k127_3748793_2 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000000000000000000000002137 192.0
TLS2_k127_3748793_3 Dehydrogenase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000007825 157.0
TLS2_k127_3748793_4 haemagglutination activity domain - - - 0.000000000000000000000001351 109.0
TLS2_k127_3748793_5 Protein conserved in bacteria K09978 - - 0.000000000000000000004889 98.0
TLS2_k127_3748793_6 YnbE-like lipoprotein - - - 0.00000000001292 71.0
TLS2_k127_3750160_0 membrane K08978 - - 0.000000000000000000000000000007541 125.0
TLS2_k127_3750160_1 Uncharacterized protein conserved in bacteria (DUF2188) - - - 0.000000000000000000000000001578 115.0
TLS2_k127_3750160_2 - - - - 0.0000000003053 61.0
TLS2_k127_3750473_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 362.0
TLS2_k127_3750473_1 ABC-type sugar transport system, permease component K02026,K17323 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008669 321.0
TLS2_k127_3755979_0 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005887 528.0
TLS2_k127_3755979_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 464.0
TLS2_k127_3755979_2 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 319.0
TLS2_k127_3755979_3 Alpha-L-arabinofuranosidase C-terminus K01209 - 3.2.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 287.0
TLS2_k127_3756073_0 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 426.0
TLS2_k127_3756073_1 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003194 350.0
TLS2_k127_3756073_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K21395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003356 289.0
TLS2_k127_3756073_3 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K15509 - 1.1.1.308 0.00000000000000000000000000000000000000000000000000008817 191.0
TLS2_k127_3756073_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000005627 95.0
TLS2_k127_3756073_5 NMT1-like family K02051 - - 0.000000000000000003478 86.0
TLS2_k127_3756073_6 Resolvase, N terminal domain - - - 0.00001053 49.0
TLS2_k127_3757607_0 SAF K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 576.0
TLS2_k127_3757607_1 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 403.0
TLS2_k127_3757607_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000004116 219.0
TLS2_k127_3757607_3 Tellurite resistance protein TerB K05801 - - 0.000000000000000000000000003764 115.0
TLS2_k127_3758576_0 COG0457 FOG TPR repeat - - - 5.703e-288 892.0
TLS2_k127_3758576_1 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000168 164.0
TLS2_k127_3758576_2 Belongs to the 'phage' integrase family - - - 0.000146 48.0
TLS2_k127_3766643_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007799 561.0
TLS2_k127_3766643_1 PFAM biotin lipoyl attachment domain-containing protein K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006331 278.0
TLS2_k127_3766643_2 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.000000000000000000000004144 102.0
TLS2_k127_3767191_0 ABC-type dipeptide transport system periplasmic component K02035 - - 5.588e-220 694.0
TLS2_k127_3767191_1 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000001127 209.0
TLS2_k127_3767191_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000004231 201.0
TLS2_k127_3772388_0 nitrite reductase K15864 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.2.1,1.7.99.1 5.182e-268 835.0
TLS2_k127_3772388_1 FMN_bind K19339,K19343 - - 1.693e-197 639.0
TLS2_k127_3772388_2 cytochrome d1, heme region K19345 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 562.0
TLS2_k127_3772388_3 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005186 295.0
TLS2_k127_3772388_4 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000003226 269.0
TLS2_k127_3772388_5 COG1522 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000002456 188.0
TLS2_k127_3772388_6 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000000000000000000004728 176.0
TLS2_k127_3772388_7 protein involved in response to NO K07234 - - 0.00000000000000000000000000000006066 142.0
TLS2_k127_3772388_8 Cytochrome c K19344 - - 0.0000000000000000000000002078 108.0
TLS2_k127_3772388_9 AsnC-type helix-turn-helix domain - - - 0.0007214 50.0
TLS2_k127_3774796_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 9.882e-257 809.0
TLS2_k127_3774796_1 Belongs to the TPP enzyme family - - - 2.113e-212 685.0
TLS2_k127_3774796_10 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.000000000000000000000000000000000000000000000000000000000000002675 231.0
TLS2_k127_3774796_11 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000000000000000000000000000000000000292 193.0
TLS2_k127_3774796_12 - - - - 0.0000000000000000001984 91.0
TLS2_k127_3774796_13 Methionine biosynthesis protein MetW K07755 - 2.1.1.137 0.00000000000000001231 89.0
TLS2_k127_3774796_14 - - - - 0.00000000000000004869 88.0
TLS2_k127_3774796_15 - - - - 0.000000000000007906 83.0
TLS2_k127_3774796_16 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000004607 72.0
TLS2_k127_3774796_17 - - - - 0.00000000001227 70.0
TLS2_k127_3774796_2 Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 448.0
TLS2_k127_3774796_3 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 433.0
TLS2_k127_3774796_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 387.0
TLS2_k127_3774796_5 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 334.0
TLS2_k127_3774796_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 315.0
TLS2_k127_3774796_7 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 303.0
TLS2_k127_3774796_8 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001834 291.0
TLS2_k127_3774796_9 dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009543 281.0
TLS2_k127_3775480_0 protein methyltransferase activity - - - 4.339e-209 660.0
TLS2_k127_3775480_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 558.0
TLS2_k127_3775480_10 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 299.0
TLS2_k127_3775480_11 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000007109 268.0
TLS2_k127_3775480_12 Glutathione-dependent formaldehyde-activating, GFA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009797 259.0
TLS2_k127_3775480_13 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000003247 218.0
TLS2_k127_3775480_14 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000000004444 194.0
TLS2_k127_3775480_15 FAD dependent oxidoreductase - - - 0.0000000000000000000000000003305 115.0
TLS2_k127_3775480_17 - - - - 0.00000000000002089 76.0
TLS2_k127_3775480_18 Tripartite tricarboxylate transporter TctB family - - - 0.0000003975 53.0
TLS2_k127_3775480_2 ABC-type Fe3 transport system permease component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 536.0
TLS2_k127_3775480_3 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 527.0
TLS2_k127_3775480_4 Bacterial extracellular solute-binding protein K02012,K11081 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 482.0
TLS2_k127_3775480_5 arylsulfatase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 479.0
TLS2_k127_3775480_6 Adenylate cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 455.0
TLS2_k127_3775480_7 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008426 408.0
TLS2_k127_3775480_8 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 363.0
TLS2_k127_3775480_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 339.0
TLS2_k127_3781428_0 Serine aminopeptidase, S33 - - - 7.421e-216 687.0
TLS2_k127_3781428_1 Mechanosensitive ion channel K22044 - - 0.000000007401 67.0
TLS2_k127_3781428_2 EF hand - - - 0.0000003744 58.0
TLS2_k127_3784193_0 Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA K09461 - 1.14.13.40 0.0 1011.0
TLS2_k127_3784193_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.756e-282 881.0
TLS2_k127_3784193_10 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 314.0
TLS2_k127_3784193_11 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 296.0
TLS2_k127_3784193_12 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019,K07535 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 289.0
TLS2_k127_3784193_13 Mo-molybdopterin cofactor biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000001411 208.0
TLS2_k127_3784193_14 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000000000000000000000000000000000003624 176.0
TLS2_k127_3784193_15 endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000000000000001397 185.0
TLS2_k127_3784193_16 Thioesterase superfamily K10806 - - 0.000000000000000000000000000000000000000000009984 167.0
TLS2_k127_3784193_17 DEAD/H associated K03724 - - 0.0000000000000000000000000000000000000000000808 162.0
TLS2_k127_3784193_18 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000002371 152.0
TLS2_k127_3784193_19 Involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000001946 139.0
TLS2_k127_3784193_2 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 2.45e-234 736.0
TLS2_k127_3784193_20 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000006112 120.0
TLS2_k127_3784193_21 Predicted membrane protein (DUF2335) - - - 0.0002609 48.0
TLS2_k127_3784193_22 - - - - 0.0003092 49.0
TLS2_k127_3784193_3 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 1.313e-228 719.0
TLS2_k127_3784193_4 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 6.531e-228 716.0
TLS2_k127_3784193_5 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 1.464e-206 663.0
TLS2_k127_3784193_6 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 577.0
TLS2_k127_3784193_7 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005429 520.0
TLS2_k127_3784193_8 PFAM Glycosyl transferase family 2 K03669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000366 524.0
TLS2_k127_3784193_9 COG1024 Enoyl-CoA hydratase carnithine racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 389.0
TLS2_k127_3790733_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 581.0
TLS2_k127_3790733_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008673 556.0
TLS2_k127_3790733_10 SIS domain K00820 - 2.6.1.16 0.0000000000000003125 78.0
TLS2_k127_3790733_11 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000006213 78.0
TLS2_k127_3790733_2 PFAM Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001483 477.0
TLS2_k127_3790733_3 Ribonuclease E/G family - - - 0.0000000000000000000000000000000000000000000000000000000000000001434 243.0
TLS2_k127_3790733_4 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000002864 226.0
TLS2_k127_3790733_5 Low molecular weight phosphatase family K01104,K03741 - 1.20.4.1,3.1.3.48 0.000000000000000000000000000000000000000000000000000000001257 210.0
TLS2_k127_3790733_6 Uncharacterised protein family (UPF0262) - - - 0.00000000000000000000000000000000000000000000000000003369 203.0
TLS2_k127_3790733_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000002073 138.0
TLS2_k127_3790733_8 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.00000000000000000000000000000001971 129.0
TLS2_k127_3790733_9 Protein of unknown function (DUF2948) - - - 0.000000000000000000000000000004044 125.0
TLS2_k127_3794400_0 Type III K03224 - 3.6.3.14 2.401e-207 665.0
TLS2_k127_3794400_1 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 446.0
TLS2_k127_3794400_10 Type III secretion protein YscO K04056 - - 0.00000000000000003116 91.0
TLS2_k127_3794400_11 - - - - 0.000000000003898 76.0
TLS2_k127_3794400_12 - - - - 0.00000000004978 68.0
TLS2_k127_3794400_13 - - - - 0.000000008558 64.0
TLS2_k127_3794400_14 - - - - 0.0000000744 61.0
TLS2_k127_3794400_16 P63C domain - - - 0.00009032 53.0
TLS2_k127_3794400_2 Type III K03229 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009056 311.0
TLS2_k127_3794400_3 FliP family K03226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003093 253.0
TLS2_k127_3794400_4 Secretory protein of YscJ/FliF family K03222 - - 0.000000000000000000000000000000000000000000000000000000000000001993 226.0
TLS2_k127_3794400_5 Type III secretion K03228 - - 0.00000000000000000000000000000000000000000000000000000006322 209.0
TLS2_k127_3794400_6 Type III K03223 - - 0.0000000000000000000000000000000000000003665 164.0
TLS2_k127_3794400_7 Type III secretion protein HrpO K03227 - - 0.0000000000000000000001063 100.0
TLS2_k127_3794400_8 Type III flagellar switch regulator (C-ring) FliN C-term K03225 - - 0.0000000000000000000139 107.0
TLS2_k127_3794400_9 This protein is involved in the repair of mismatches in DNA K03555 - - 0.00000000000000000001689 93.0
TLS2_k127_3797432_0 FAD dependent oxidoreductase K19191 GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 0.0 1007.0
TLS2_k127_3797674_0 AAA domain - - - 0.0 1045.0
TLS2_k127_3797674_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 588.0
TLS2_k127_3797674_10 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000005005 82.0
TLS2_k127_3797674_11 Plasmid stability protein K21495 - - 0.0000428 51.0
TLS2_k127_3797674_2 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002167 535.0
TLS2_k127_3797674_3 PFAM D-galactarate dehydratase Altronate hydrolase, C terminus K01685 - 4.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006436 487.0
TLS2_k127_3797674_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 457.0
TLS2_k127_3797674_5 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 455.0
TLS2_k127_3797674_6 YCII-related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001573 252.0
TLS2_k127_3797674_7 Zincin-like metallopeptidase - - - 0.000000000000000000000000000000000000000000834 161.0
TLS2_k127_3797674_8 Trap-type c4-dicarboxylate transport system, small permease component K11689 - - 0.00000000000000000000000000000000001573 144.0
TLS2_k127_3797674_9 Domain of unknown function DUF29 - - - 0.0000000000000000000000000001687 121.0
TLS2_k127_3808248_0 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004341 373.0
TLS2_k127_3808248_1 Protein of unknown function (DUF993) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001692 252.0
TLS2_k127_3811740_0 Aminotransferase class-III K00819 - 2.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 591.0
TLS2_k127_3811740_1 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 452.0
TLS2_k127_3811740_10 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000001246 133.0
TLS2_k127_3811740_11 - - - - 0.00000000000002155 74.0
TLS2_k127_3811740_2 COG3454 Metal-dependent hydrolase involved in phosphonate metabolism K06162 - 3.6.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 401.0
TLS2_k127_3811740_3 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007875 384.0
TLS2_k127_3811740_4 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 383.0
TLS2_k127_3811740_5 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004051 278.0
TLS2_k127_3811740_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001103 265.0
TLS2_k127_3811740_7 Belongs to the CinA family - - - 0.00000000000000000000000000000000000000000000000000000000001601 210.0
TLS2_k127_3811740_8 Protein of unknown function (DUF1045) - - - 0.000000000000000000000000000000000000000000000000000005731 199.0
TLS2_k127_3811740_9 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000597 191.0
TLS2_k127_3811857_0 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008503 437.0
TLS2_k127_3811857_1 DDE_Tnp_1-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 367.0
TLS2_k127_381980_0 DNA helicase K03654 - 3.6.4.12 1.031e-236 745.0
TLS2_k127_381980_1 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 552.0
TLS2_k127_381980_10 Protein of unknown function (DUF3018) - - - 0.00000000000000000003166 92.0
TLS2_k127_381980_11 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00002929 49.0
TLS2_k127_381980_2 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009403 537.0
TLS2_k127_381980_3 TOBE domain K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 434.0
TLS2_k127_381980_4 ABC-type spermidine putrescine transport system, permease component II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 413.0
TLS2_k127_381980_5 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 394.0
TLS2_k127_381980_6 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004281 400.0
TLS2_k127_381980_7 RadC-like JAB domain K03630 GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 292.0
TLS2_k127_381980_8 Belongs to the SfsA family K06206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001183 269.0
TLS2_k127_381980_9 growth inhibitor K07171 - - 0.0000000000000000000000000000000000000004271 156.0
TLS2_k127_3828863_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046,K13797 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1146.0
TLS2_k127_3828863_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1069.0
TLS2_k127_3828863_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000001034 237.0
TLS2_k127_3828863_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000008763 235.0
TLS2_k127_3828863_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000007301 104.0
TLS2_k127_3830986_0 Bacterial extracellular solute-binding protein, family 7 K21395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000089 475.0
TLS2_k127_3830986_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 316.0
TLS2_k127_3830986_2 TRAP transporter small transmembrane protein - - - 0.00000000000000000000000000000000000000000000000003655 184.0
TLS2_k127_3830986_3 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000002973 148.0
TLS2_k127_3830986_4 Cache domain - - - 0.000000000000000000000000000001424 131.0
TLS2_k127_3835193_0 ATPases associated with a variety of cellular activities K06148,K16299 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 491.0
TLS2_k127_3835193_1 Predicted membrane protein (DUF2254) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 403.0
TLS2_k127_3835193_2 HlyD membrane-fusion protein of T1SS K02022 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 325.0
TLS2_k127_3835193_3 TIGRFAM outer membrane adhesin like proteiin - - - 0.0000000000000000000000000000000000000001218 175.0
TLS2_k127_3835193_4 Cytochrome c oxidase subunit III - - - 0.00000000000000000002784 90.0
TLS2_k127_3835193_5 - - - - 0.0000006038 58.0
TLS2_k127_3835266_0 His Kinase A (phospho-acceptor) domain - - - 0.0 1048.0
TLS2_k127_3835266_1 4Fe-4S dicluster domain - - - 1.211e-257 816.0
TLS2_k127_3835266_10 dUTPase K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000001911 207.0
TLS2_k127_3835266_11 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000003535 207.0
TLS2_k127_3835266_12 Protein phosphatase 2C - - - 0.0000000000000000000000000000000000000000000000003911 185.0
TLS2_k127_3835266_13 Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000001553 169.0
TLS2_k127_3835266_14 PFAM OmpA MotB domain protein - - - 0.0000000000000000000001906 106.0
TLS2_k127_3835266_15 Bacterial protein of unknown function (DUF883) - - - 0.000000000001714 74.0
TLS2_k127_3835266_16 Putative peptidoglycan binding domain - - - 0.0000000002398 70.0
TLS2_k127_3835266_17 - - - - 0.0000000008855 61.0
TLS2_k127_3835266_2 DNA polymerase III K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 486.0
TLS2_k127_3835266_3 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 456.0
TLS2_k127_3835266_4 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 347.0
TLS2_k127_3835266_5 Ligated ion channel L-glutamate- and glycine-binding site K10018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 319.0
TLS2_k127_3835266_6 Binding-protein-dependent transport system inner membrane component K02029,K10020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 301.0
TLS2_k127_3835266_7 Cytochrome c3 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 317.0
TLS2_k127_3835266_8 Binding-protein-dependent transport system inner membrane component K02029,K10019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007243 305.0
TLS2_k127_3835266_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002267 275.0
TLS2_k127_3838162_0 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 460.0
TLS2_k127_3838162_1 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 418.0
TLS2_k127_3838162_2 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 406.0
TLS2_k127_3838162_3 ABC-type transport system, permease components - - - 0.0000000000000000000000000000000000000000001204 164.0
TLS2_k127_3838162_4 nuclear chromosome segregation - - - 0.0002131 53.0
TLS2_k127_3846942_0 Belongs to the ABC transporter superfamily K12372 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 413.0
TLS2_k127_3846942_1 SMART metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006378 360.0
TLS2_k127_3846942_2 Belongs to the ABC transporter superfamily K02031,K12371 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009904 291.0
TLS2_k127_3846942_3 polysaccharide biosynthetic process K00655,K00721 - 2.3.1.51,2.4.1.83 0.0000000000000000000000000000000000000000000000000000000003116 224.0
TLS2_k127_3846942_4 Domain of unknown function DUF29 - - - 0.00000000000000000000000000000000002595 140.0
TLS2_k127_3846942_5 - - - - 0.0000000000103 71.0
TLS2_k127_3851862_0 Belongs to the GcvT family K00315,K19191 - 1.5.3.19,1.5.8.4 0.0 1195.0
TLS2_k127_3851862_1 PFAM binding-protein-dependent transport systems inner membrane component K02037 - - 7.714e-286 898.0
TLS2_k127_3851862_10 Belongs to the flagella basal body rod proteins family K02391 - - 0.000000000000000000000000000000000000000000000000000000000000008473 226.0
TLS2_k127_3851862_11 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000000000002101 179.0
TLS2_k127_3851862_12 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000004961 147.0
TLS2_k127_3851862_13 Zn peptidase - - - 0.000000000000000000000000000008197 124.0
TLS2_k127_3851862_14 PFAM MgtE intracellular - - - 0.000000000000000000000000013 123.0
TLS2_k127_3851862_15 Controls the rotational direction of flagella during chemotaxis K02415 - - 0.00000000000000000000002936 106.0
TLS2_k127_3851862_16 Flagellar basal body P-ring biosynthesis protein K02386 - - 0.00000000000000078 91.0
TLS2_k127_3851862_17 Peptidase propeptide and YPEB domain - - - 0.0000002636 56.0
TLS2_k127_3851862_18 - - - - 0.0007516 52.0
TLS2_k127_3851862_2 PFAM binding-protein-dependent transport systems inner membrane component K02038 - - 2.475e-212 670.0
TLS2_k127_3851862_3 TIGRFAM phosphate binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 497.0
TLS2_k127_3851862_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000397 431.0
TLS2_k127_3851862_5 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 418.0
TLS2_k127_3851862_6 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 368.0
TLS2_k127_3851862_7 Belongs to the flagella basal body rod proteins family K02392 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 365.0
TLS2_k127_3851862_8 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 297.0
TLS2_k127_3851862_9 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003838 293.0
TLS2_k127_3852469_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.337e-224 705.0
TLS2_k127_3852469_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 443.0
TLS2_k127_3860050_0 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 460.0
TLS2_k127_3860050_1 Bacterial sugar transferase K00996,K16566 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.6 0.00000000000000000000000000000000000000000000000000000000000000000002467 234.0
TLS2_k127_3860707_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 529.0
TLS2_k127_3860707_1 HNH endonuclease - - - 0.00000000000000000001369 95.0
TLS2_k127_3860707_2 decarboxylase K01607 - 4.1.1.44 0.000000000000006509 76.0
TLS2_k127_3872271_0 methionine synthase K00544,K00548 - 2.1.1.13,2.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 493.0
TLS2_k127_3872271_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002673 317.0
TLS2_k127_3872271_2 With different specificities (related to short-chain alcohol - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 301.0
TLS2_k127_3884471_0 ATPase (AAA K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008019 395.0
TLS2_k127_3884471_1 PFAM cyclase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 329.0
TLS2_k127_3884471_2 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000005763 208.0
TLS2_k127_3884471_3 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000000000065 114.0
TLS2_k127_3885953_0 Precorrin-3B K05934,K13541 - 2.1.1.131,3.7.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 590.0
TLS2_k127_3885953_1 fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 510.0
TLS2_k127_3885953_10 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.000000000000000000000000000000000000000000000000000000000000000005172 237.0
TLS2_k127_3885953_11 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000000000000000000000000000000000008253 194.0
TLS2_k127_3885953_12 - - - - 0.0000000000001761 74.0
TLS2_k127_3885953_13 - - - - 0.00000000002237 69.0
TLS2_k127_3885953_2 Domain of unknown function DUF87 K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 496.0
TLS2_k127_3885953_3 PFAM Mandelate racemase muconate lactonizing K20023 - 4.2.1.156,4.2.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008529 475.0
TLS2_k127_3885953_4 Precorrin-6Y C5,15-methyltransferase K00595 - 2.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003695 462.0
TLS2_k127_3885953_5 CbiX K03795 - 4.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009084 425.0
TLS2_k127_3885953_6 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 400.0
TLS2_k127_3885953_7 Precorrin-4 K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 364.0
TLS2_k127_3885953_8 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 294.0
TLS2_k127_3885953_9 Nitrite and sulphite reductase 4Fe-4S K00366 - 1.7.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000002327 247.0
TLS2_k127_3901287_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.364e-205 655.0
TLS2_k127_3901287_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 479.0
TLS2_k127_3901287_2 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 465.0
TLS2_k127_3901287_3 Beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 362.0
TLS2_k127_3901287_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005446 272.0
TLS2_k127_3901287_5 Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000001147 90.0
TLS2_k127_3904829_0 COG1960 Acyl-CoA dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 551.0
TLS2_k127_3904829_1 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 382.0
TLS2_k127_3904829_2 Enoyl-CoA hydratase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000334 355.0
TLS2_k127_3904829_3 COG1846 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000001568 209.0
TLS2_k127_3904829_4 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000001371 151.0
TLS2_k127_3904829_5 DDE superfamily endonuclease - - - 0.0000000000000000000000000003161 119.0
TLS2_k127_3912067_0 Filamentation induced by cAMP protein fic - - - 3.711e-232 728.0
TLS2_k127_3912067_1 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase K01826 - 5.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 457.0
TLS2_k127_3912067_2 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 339.0
TLS2_k127_3912067_3 with different specificities (related to short-chain alcohol K00019,K18335 - 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 320.0
TLS2_k127_3912067_4 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 309.0
TLS2_k127_3912067_5 Transposase - - - 0.000000000000000000000000000000000000000000000000000003873 193.0
TLS2_k127_3912067_6 Acyltransferase family - - - 0.000000000000000000000000000000000000199 158.0
TLS2_k127_3912067_7 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.000000000000000000005073 103.0
TLS2_k127_3912067_8 cheY-homologous receiver domain - - - 0.00000000000000000214 87.0
TLS2_k127_3918896_0 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 375.0
TLS2_k127_3918896_1 PFAM transposase, IS4 family protein - - - 0.0000000000000000000000003709 111.0
TLS2_k127_3918896_2 Transposase IS66 family - - - 0.000000000000006731 79.0
TLS2_k127_3918896_3 Transposase and inactivated derivatives - - - 0.000000002484 59.0
TLS2_k127_3918896_4 Transposase DDE domain - - - 0.0004557 49.0
TLS2_k127_392317_0 UV-endonuclease UvdE K13281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 523.0
TLS2_k127_392317_1 ABC-type sugar transport system, periplasmic component K02027 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 456.0
TLS2_k127_392317_2 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 410.0
TLS2_k127_392317_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 348.0
TLS2_k127_392317_4 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001294 260.0
TLS2_k127_392317_5 SMART PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000252 256.0
TLS2_k127_392317_7 Beta-galactosidase K12308 - 3.2.1.23 0.0000000000000000000000000000000000000000004251 158.0
TLS2_k127_3941425_0 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000003773 223.0
TLS2_k127_3941425_1 PFAM Cobyrinic acid a,c-diamide synthase - - - 0.00000000000000000000000000000000000000000000000002328 182.0
TLS2_k127_3945933_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 5.066e-248 778.0
TLS2_k127_3945933_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000644 536.0
TLS2_k127_3945933_2 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000001246 215.0
TLS2_k127_394713_0 COG3839 ABC-type sugar transport systems, ATPase components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 405.0
TLS2_k127_394713_1 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000004615 222.0
TLS2_k127_394713_2 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000007411 228.0
TLS2_k127_394713_3 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000009938 90.0
TLS2_k127_3958285_0 Dioxygenase K00448 - 1.13.11.3 0.0000000000000000000000000000000000000000000001654 176.0
TLS2_k127_3958285_1 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000003158 114.0
TLS2_k127_3958285_2 Dioxygenase - - - 0.0000000000002427 71.0
TLS2_k127_3961419_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 585.0
TLS2_k127_3961419_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 422.0
TLS2_k127_3961419_2 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009248 357.0
TLS2_k127_3961419_3 ABC transporter transmembrane region K06148,K16299 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 319.0
TLS2_k127_3961419_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003879 292.0
TLS2_k127_3961419_5 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000001045 226.0
TLS2_k127_3961419_6 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000005065 216.0
TLS2_k127_3961419_7 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.0000000000000000000000000000000000000008532 166.0
TLS2_k127_3961419_8 BFD-like [2Fe-2S] binding domain - - - 0.000001115 56.0
TLS2_k127_3974367_0 sulfate adenylyltransferase (ATP) activity K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 429.0
TLS2_k127_3974367_1 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 313.0
TLS2_k127_3974367_2 Glycosyl transferase family 2 K13683 - - 0.0000000000000000000000000000000000002362 151.0
TLS2_k127_3986368_0 Fumarase C C-terminus K01744 - 4.3.1.1 3.509e-236 740.0
TLS2_k127_3986368_1 Oxidative deamination of D-amino acids K00285 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0008718,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019478,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055114,GO:0055130,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.5.1 1.231e-194 615.0
TLS2_k127_3986368_2 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003256 463.0
TLS2_k127_3986368_3 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005854 269.0
TLS2_k127_3990266_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 8.372e-304 945.0
TLS2_k127_3990266_1 Hydantoinase B/oxoprolinase - - - 1.024e-273 853.0
TLS2_k127_3990266_2 Required for the activity of the bacterial periplasmic transport system of putrescine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 593.0
TLS2_k127_3990266_3 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 446.0
TLS2_k127_3990266_4 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 414.0
TLS2_k127_3990266_5 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 401.0
TLS2_k127_3990266_6 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 395.0
TLS2_k127_3990266_7 Hydantoinase B/oxoprolinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 291.0
TLS2_k127_3990266_8 Tpr repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000005543 207.0
TLS2_k127_4000993_0 NUDIX domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002541 242.0
TLS2_k127_4000993_1 Domain of unknown function (DUF697) K08990 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000001007 200.0
TLS2_k127_4000993_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000008292 141.0
TLS2_k127_4000993_3 YcjX-like family, DUF463 K06918 - - 0.00000000000000639 75.0
TLS2_k127_4000993_4 Protein of unknown function (DUF1192) - - - 0.00001725 53.0
TLS2_k127_4002334_0 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 396.0
TLS2_k127_4002334_1 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 GO:0001522,GO:0003674,GO:0003824,GO:0004730,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016043,GO:0016070,GO:0016787,GO:0016798,GO:0016829,GO:0016835,GO:0016836,GO:0022607,GO:0030145,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0090304,GO:1901360 4.2.1.70 0.00000000000415 70.0
TLS2_k127_4024349_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008919 548.0
TLS2_k127_4024349_1 COG1494 Fructose-1,6-bisphosphatase sedoheptulose 1,7-bisphosphatase and related proteins K11532 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 489.0
TLS2_k127_4024349_2 single-stranded-DNA-specific exonuclease recJ K07462 - - 0.000000000000000000000111 100.0
TLS2_k127_4024349_3 Aminotransferase K14261 - - 0.0000000005209 61.0
TLS2_k127_4024776_0 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 467.0
TLS2_k127_4024776_1 Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum K13626 - - 0.0000000000000000000000000003547 120.0
TLS2_k127_4029332_0 Dehydrogenase K15371 - 1.4.1.2 0.0 1570.0
TLS2_k127_4029332_1 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003927 606.0
TLS2_k127_4029332_2 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 298.0
TLS2_k127_4029332_3 Phospholipid N-methyltransferase K00570 - 2.1.1.17,2.1.1.71 0.000000000000000000000000000000000000000000000000000000000000002627 222.0
TLS2_k127_4029332_4 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000002165 198.0
TLS2_k127_4029332_5 TRAP-type mannitol chloroaromatic compound transport system small permease component - - - 0.0000000000000000000000000000000000000000000000001328 189.0
TLS2_k127_4029332_6 acetyltransferase - - - 0.000000000000000000000000000000000002091 143.0
TLS2_k127_4029332_7 Domain of unknown function DUF29 - - - 0.00000000000000000000000000000000006297 138.0
TLS2_k127_4029332_8 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000001501 124.0
TLS2_k127_4035495_0 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 593.0
TLS2_k127_4035495_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 497.0
TLS2_k127_4035495_10 Biotin-lipoyl like K02022 - - 0.0003489 51.0
TLS2_k127_4035495_2 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 490.0
TLS2_k127_4035495_3 RNA polymerase sigma K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 440.0
TLS2_k127_4035495_4 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 360.0
TLS2_k127_4035495_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 359.0
TLS2_k127_4035495_6 Sodium:sulfate symporter transmembrane region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002967 254.0
TLS2_k127_4035495_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000001302 146.0
TLS2_k127_4035495_8 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.000000000003094 68.0
TLS2_k127_4041201_0 Glycosyl transferase 4-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 462.0
TLS2_k127_4041201_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 306.0
TLS2_k127_4050688_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 1.027e-301 954.0
TLS2_k127_4050688_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.012e-226 714.0
TLS2_k127_4050688_10 - - - - 0.000009081 50.0
TLS2_k127_4050688_2 Belongs to the AdoMet synthase family K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 530.0
TLS2_k127_4050688_3 Helix-hairpin-helix domain K04477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 331.0
TLS2_k127_4050688_4 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004179 253.0
TLS2_k127_4050688_5 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000003407 242.0
TLS2_k127_4050688_6 Nitroreductase family - - - 0.0000000000000000000000000000000000004104 147.0
TLS2_k127_4050688_7 2-hydroxychromene-2-carboxylate isomerase - - - 0.000000005867 56.0
TLS2_k127_4050688_9 PFAM Nitroreductase - - - 0.000003034 53.0
TLS2_k127_4062360_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01539 - 3.6.3.9 1.758e-293 921.0
TLS2_k127_4062360_1 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000000000000000000000000000000000751 204.0
TLS2_k127_4062360_2 Hsp20/alpha crystallin family K13993 - - 0.000000000000000000000000000000000002409 144.0
TLS2_k127_4062360_3 Universal stress protein family - - - 0.000000000000000005159 84.0
TLS2_k127_4065713_0 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 519.0
TLS2_k127_4065713_1 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 502.0
TLS2_k127_4065713_2 acid transport system permease K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 494.0
TLS2_k127_4065713_3 PFAM Cys Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 486.0
TLS2_k127_4065713_4 COG0765 ABC-type amino acid transport system, permease component K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 494.0
TLS2_k127_4065713_5 ATPases associated with a variety of cellular activities K02028,K02029,K09972,K10010 GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21 0.0000000000000000000000000000000000000000000000000000000000000000000000001884 251.0
TLS2_k127_4104378_0 Formate dehydrogenase, beta subunit K00122 - 1.17.1.9 5.619e-248 779.0
TLS2_k127_4104378_1 metal-dependent hydrolase of the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000000003129 195.0
TLS2_k127_4104378_2 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000001402 162.0
TLS2_k127_4104378_3 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0000000000000000003 101.0
TLS2_k127_4104378_4 positive regulation of growth - - - 0.0000000000001138 72.0
TLS2_k127_4104378_5 Bacterial SH3 domain homologues - - - 0.000001318 61.0
TLS2_k127_4106187_0 PFAM Conserved region in glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2290.0
TLS2_k127_4106187_1 COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases K00266 - 1.4.1.13,1.4.1.14 1.135e-234 737.0
TLS2_k127_4106187_10 Protein of unknown function (DUF3445) K22342 - 1.14.13.238 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003085 284.0
TLS2_k127_4106187_11 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004871 281.0
TLS2_k127_4106187_12 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000236 204.0
TLS2_k127_4106187_13 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000009082 186.0
TLS2_k127_4106187_14 tetR family - - - 0.000000000000000000000000000000000000000000001083 174.0
TLS2_k127_4106187_15 Pentapeptide repeats (9 copies) - - - 0.000000000005822 76.0
TLS2_k127_4106187_16 lipolytic protein G-D-S-L family - - - 0.000000000006302 78.0
TLS2_k127_4106187_18 - - - - 0.0004606 51.0
TLS2_k127_4106187_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 546.0
TLS2_k127_4106187_3 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 541.0
TLS2_k127_4106187_4 Binding-protein-dependent transport system inner membrane component K12369 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 518.0
TLS2_k127_4106187_5 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K12370 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 429.0
TLS2_k127_4106187_6 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 415.0
TLS2_k127_4106187_7 MatE K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 379.0
TLS2_k127_4106187_8 Transketolase, pyrimidine binding domain K11381,K21416 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 344.0
TLS2_k127_4106187_9 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001283 286.0
TLS2_k127_4109089_0 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 454.0
TLS2_k127_4109089_1 racemase activity, acting on amino acids and derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 342.0
TLS2_k127_4109089_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000001849 115.0
TLS2_k127_4109089_3 Polycystin cation channel K08714 - - 0.0000000002477 63.0
TLS2_k127_4127830_0 cell division K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003177 253.0
TLS2_k127_4127830_1 Protein of unknown function (DUF3426) - - - 0.000000000000000000000000000000003843 136.0
TLS2_k127_4127830_2 Cell division protein K09811 - - 0.0000000000000000000000005379 119.0
TLS2_k127_4132607_0 Required for the activity of the bacterial periplasmic transport system of putrescine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 341.0
TLS2_k127_4132607_1 ABC-type spermidine putrescine transport system, permease component I K02054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 345.0
TLS2_k127_413359_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000001962 243.0
TLS2_k127_413359_1 Small multidrug resistance protein K11741 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000665 168.0
TLS2_k127_413359_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - - 0.000000000000000000001316 95.0
TLS2_k127_413359_3 PFAM Uncharacterised protein family UPF0150 - - - 0.0000000000000002957 80.0
TLS2_k127_4138772_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002858 398.0
TLS2_k127_4138772_1 Cytochrome c K00413 - - 0.0000000000000000000003934 100.0
TLS2_k127_4138772_2 L-galactose dehydrogenase K17744 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010349,GO:0016051,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0019852,GO:0019853,GO:0042364,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045290,GO:0046364,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0070484,GO:0070485,GO:0071704,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901576 1.1.1.316 0.000134 47.0
TLS2_k127_4140356_0 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 472.0
TLS2_k127_4140356_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 384.0
TLS2_k127_4140356_2 Required for the activity of the bacterial periplasmic transport system of putrescine - - - 0.000000000000000000000000000000000000000000000000000000000008802 219.0
TLS2_k127_4140356_3 GYD domain - - - 0.00000000000000000000000387 105.0
TLS2_k127_4140808_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 407.0
TLS2_k127_4140808_1 Glycosyl hydrolase family 14 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 405.0
TLS2_k127_4140808_10 UMP kinase activity K00947,K09903 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 2.7.4.22 0.0000000001055 65.0
TLS2_k127_4140808_11 UMP kinase activity K00947,K09903 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 2.7.4.22 0.00000007245 59.0
TLS2_k127_4140808_2 xylan catabolic process K03932 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 383.0
TLS2_k127_4140808_3 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 337.0
TLS2_k127_4140808_4 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 294.0
TLS2_k127_4140808_5 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003305 266.0
TLS2_k127_4140808_7 UMP kinase activity K00947,K09903 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 2.7.4.22 0.000000000000000000000001047 105.0
TLS2_k127_4140808_8 Protein of unknown function (DUF433) - - - 0.0000000000001075 74.0
TLS2_k127_4140808_9 UMP kinase activity K00947,K09903 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0030151,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 2.7.4.22 0.000000000003697 68.0
TLS2_k127_4145431_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 511.0
TLS2_k127_4145431_1 enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 317.0
TLS2_k127_4145431_2 phenylacetic acid degradation protein K02614 GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790 - 0.00000000000000000000000000000000000000000002647 169.0
TLS2_k127_4145431_3 oxidoreductase - - - 0.00000000000000000000000000000000007939 137.0
TLS2_k127_4146195_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 347.0
TLS2_k127_4146195_1 Luciferase-like monooxygenase - - - 0.0000003161 54.0
TLS2_k127_4155497_0 Glycosyl hydrolases family 2, sugar binding domain - - - 4.103e-316 992.0
TLS2_k127_4155497_1 Glycosyl hydrolase family 1 K00067 - 1.1.1.133 2.016e-241 769.0
TLS2_k127_4155497_10 Bifunctional DNA primase/polymerase, N-terminal - - - 0.000000000000000002659 96.0
TLS2_k127_4155497_11 Prophage CP4-57 regulatory protein (AlpA) - - - 0.00000000006166 65.0
TLS2_k127_4155497_2 UDP-galactopyranose mutase K01854 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008767,GO:0016853,GO:0016866,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 599.0
TLS2_k127_4155497_3 beta-glucosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 535.0
TLS2_k127_4155497_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006701 496.0
TLS2_k127_4155497_5 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009189 467.0
TLS2_k127_4155497_6 TrkA-C domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007002 276.0
TLS2_k127_4155497_7 Phage plasmid primase P4 family - - - 0.00000000000000000000000000000000000000000000000000000000000009614 222.0
TLS2_k127_4155497_8 Resolvase, N terminal domain - - - 0.00000000000000000000000000000000000000000000000001238 183.0
TLS2_k127_4155497_9 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000007142 128.0
TLS2_k127_4172244_0 Biotin carboxylase - - - 1.826e-254 790.0
TLS2_k127_4172244_1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 471.0
TLS2_k127_4172244_2 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 415.0
TLS2_k127_4172244_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000003804 208.0
TLS2_k127_4174082_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 3.959e-217 691.0
TLS2_k127_4174082_1 trisaccharide binding K01768 - 4.6.1.1 9.409e-195 635.0
TLS2_k127_4174082_2 helix_turn_helix ASNC type K05800 - - 0.0000000000000000000000000000000000000001634 173.0
TLS2_k127_4174082_3 histone H2A K63-linked ubiquitination K03220 - - 0.000001195 57.0
TLS2_k127_4174687_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18989 - - 0.0 1272.0
TLS2_k127_4174687_1 Domain of unknown function (DUF4445) - - - 1.35e-316 983.0
TLS2_k127_4174687_10 Virulence factor - - - 0.000000000000000000000000000001002 128.0
TLS2_k127_4174687_11 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000001678 69.0
TLS2_k127_4174687_12 Rv0623-like transcription factor K19687 GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007 - 0.000007018 51.0
TLS2_k127_4174687_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 5.037e-296 927.0
TLS2_k127_4174687_3 CO dehydrogenase/acetyl-CoA synthase delta subunit K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 467.0
TLS2_k127_4174687_4 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 399.0
TLS2_k127_4174687_5 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 361.0
TLS2_k127_4174687_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 325.0
TLS2_k127_4174687_7 Protein of unknown function (DUF1638) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000195 258.0
TLS2_k127_4174687_8 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01485,K01487,K11991 - 3.5.4.1,3.5.4.3,3.5.4.33 0.00000000000000000000000000000000000000000000000000000000000000004448 226.0
TLS2_k127_4174687_9 Belongs to the DegT DnrJ EryC1 family K07806 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363 2.6.1.87 0.0000000000000000000000000000000000000000000000000000000001978 218.0
TLS2_k127_4177091_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1099.0
TLS2_k127_4177091_1 PFAM peptidase S15 K06978 - - 3.282e-242 757.0
TLS2_k127_4177091_2 C-terminal, D2-small domain, of ClpB protein K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000008755 252.0
TLS2_k127_4177091_3 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000003416 245.0
TLS2_k127_4177091_4 Protein of unknown function (DUF541) K09797 - - 0.0000000000000000000000000000000000000000000000000000000000000000008729 236.0
TLS2_k127_4177091_5 Tellurite resistance protein TerB - - - 0.000000000000000000000000000000000000003419 153.0
TLS2_k127_4177091_6 Late embryogenesis abundant protein - - - 0.00000000000000000004888 95.0
TLS2_k127_4177091_7 - - - - 0.00000001867 63.0
TLS2_k127_4177091_8 Protein of unknown function (DUF1778) - - - 0.000001351 52.0
TLS2_k127_4177091_9 - - - - 0.00004913 47.0
TLS2_k127_418122_0 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000002751 182.0
TLS2_k127_418122_1 Protein of unknown function (DUF3618) - - - 0.0000000000008039 79.0
TLS2_k127_4189139_0 Flavodoxin-like fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 469.0
TLS2_k127_4189139_1 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004203 414.0
TLS2_k127_4189139_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 359.0
TLS2_k127_4189139_3 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 332.0
TLS2_k127_4189139_4 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004908 259.0
TLS2_k127_4189139_5 probably involved in intracellular septation K06190 - - 0.000000000000000000000000000000000000000000000000000000000000000008731 229.0
TLS2_k127_4189139_6 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.0000000000000000000000000000000000000000000000005408 184.0
TLS2_k127_4189139_7 - - - - 0.000000000000000000000000000000003023 128.0
TLS2_k127_4189139_8 CsbD-like - - - 0.0000000103 60.0
TLS2_k127_4202286_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000002652 200.0
TLS2_k127_4202286_1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000000000000000000000000000000000004419 157.0
TLS2_k127_4202286_2 PAS fold - - - 0.0000000000000005283 78.0
TLS2_k127_4202286_3 helix_turn_helix, Lux Regulon K14987 - - 0.0000000000005036 74.0
TLS2_k127_420381_0 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 342.0
TLS2_k127_420381_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000002346 274.0
TLS2_k127_420381_2 Pfam:PNPOx_C K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000009022 271.0
TLS2_k127_4215423_0 FAD binding domain K05712 - 1.14.13.127 9.774e-206 655.0
TLS2_k127_4215423_1 Amidohydrolase family K01487 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008892,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0016814,GO:0018756,GO:0019239,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0046098,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564 3.5.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 517.0
TLS2_k127_4215423_10 COG0517 FOG CBS domain - - - 0.0000000000000000000000000000000000000000000662 164.0
TLS2_k127_4215423_11 Transglycosylase - - - 0.000000000000000000000000000001627 126.0
TLS2_k127_4215423_12 Protein of unknown function (DUF541) - - - 0.000000000000000001324 95.0
TLS2_k127_4215423_13 Protein of unknown function (DUF2783) - - - 0.000000000001548 77.0
TLS2_k127_4215423_2 Belongs to the CinA family K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 499.0
TLS2_k127_4215423_3 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 499.0
TLS2_k127_4215423_4 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 478.0
TLS2_k127_4215423_5 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005964 451.0
TLS2_k127_4215423_6 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002649 271.0
TLS2_k127_4215423_7 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006475 263.0
TLS2_k127_4215423_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000002061 246.0
TLS2_k127_4215423_9 polysaccharide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000004639 199.0
TLS2_k127_4244679_0 Transporter associated domain K03699 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 469.0
TLS2_k127_4244679_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000886 48.0
TLS2_k127_4251696_0 AsmA family K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003932 492.0
TLS2_k127_425613_0 EAL domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000794 340.0
TLS2_k127_425613_1 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 318.0
TLS2_k127_425613_2 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001957 279.0
TLS2_k127_425613_3 S-adenosyl-L-methionine methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000005941 205.0
TLS2_k127_425613_4 Belongs to the ParA family K04562 - - 0.0000000000000000000000000000000000000000000319 166.0
TLS2_k127_425613_5 - - - - 0.000000002941 69.0
TLS2_k127_4283361_0 Aldehyde dehydrogenase family - - - 5.104e-208 661.0
TLS2_k127_4283361_1 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.000000000000000000000000000000000000000000000000000000001419 211.0
TLS2_k127_4283361_2 Membrane - - - 0.000000000000000000000000000000000001248 147.0
TLS2_k127_4283361_3 Protein of unknown function (DUF3617) - - - 0.0000000000000000000000000000004811 127.0
TLS2_k127_4287798_0 COG3547 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002714 308.0
TLS2_k127_4287798_1 DedA family - - - 0.00000000000000000000000000000000000000009654 152.0
TLS2_k127_4287798_2 SNARE associated Golgi protein - - - 0.00000000000000000000000000000001936 130.0
TLS2_k127_4299693_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 7.172e-294 921.0
TLS2_k127_4299693_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000003664 220.0
TLS2_k127_4302475_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 2.049e-298 936.0
TLS2_k127_4302475_1 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002155 280.0
TLS2_k127_4314105_0 Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 587.0
TLS2_k127_4314105_1 ABC-type multidrug transport system, ATPase and permease K02021,K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006469 508.0
TLS2_k127_4314105_2 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 434.0
TLS2_k127_4314105_3 3-deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007256 432.0
TLS2_k127_4314105_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 396.0
TLS2_k127_4314105_5 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004419 366.0
TLS2_k127_4314105_6 Helix-turn-helix domain, rpiR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 306.0
TLS2_k127_4314105_7 FAD binding domain K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000172 288.0
TLS2_k127_4314105_8 protein conserved in bacteria K09778 - - 0.00000000000000000000000000000000000000000003381 183.0
TLS2_k127_4365934_0 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005549 616.0
TLS2_k127_4365934_1 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003169 252.0
TLS2_k127_4365934_2 D-alanyl-D-alanine carboxypeptidase K17733 - - 0.0000000000000000000000000000000000000000000000000000000000145 223.0
TLS2_k127_4365934_3 TOBE domain K02052,K11072 - 3.6.3.31 0.000000000000000000000000000003056 126.0
TLS2_k127_4365934_4 - - - - 0.0001136 53.0
TLS2_k127_4373320_0 pyrroloquinoline quinone binding - - - 1.802e-271 846.0
TLS2_k127_4373320_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 4.649e-229 715.0
TLS2_k127_4373320_10 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000001748 274.0
TLS2_k127_4373320_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000000000000000002963 240.0
TLS2_k127_4373320_12 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000664 196.0
TLS2_k127_4373320_13 tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000003065 177.0
TLS2_k127_4373320_14 soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000000000000000000000000000000000433 175.0
TLS2_k127_4373320_15 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000003291 119.0
TLS2_k127_4373320_16 Plasmid maintenance system killer protein K07334 - - 0.00000000000000000000000002477 110.0
TLS2_k127_4373320_17 addiction module antidote protein HigA K21498 - - 0.0000000000000000000002716 100.0
TLS2_k127_4373320_18 PemK-like, MazF-like toxin of type II toxin-antitoxin system K07171 - - 0.00000000000000000001844 94.0
TLS2_k127_4373320_19 Protein of unknown function (DUF3141) - - - 0.00000000000000788 84.0
TLS2_k127_4373320_2 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 4.013e-206 651.0
TLS2_k127_4373320_20 periplasmic binding protein K02016 - - 0.000000000005528 68.0
TLS2_k127_4373320_21 - - - - 0.0000000001309 65.0
TLS2_k127_4373320_22 abc transporter K02013 - 3.6.3.34 0.000002371 57.0
TLS2_k127_4373320_23 N-terminal domain of cytochrome oxidase-cbb3, FixP - - - 0.0001758 50.0
TLS2_k127_4373320_3 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 2.91e-197 627.0
TLS2_k127_4373320_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 553.0
TLS2_k127_4373320_5 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 523.0
TLS2_k127_4373320_6 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 381.0
TLS2_k127_4373320_7 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008565 373.0
TLS2_k127_4373320_8 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 290.0
TLS2_k127_4373320_9 COG3090 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005428 262.0
TLS2_k127_437596_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 506.0
TLS2_k127_437596_1 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001332 262.0
TLS2_k127_437596_2 - K11477 - - 0.0000000000000000000000000000000000000000000000009273 180.0
TLS2_k127_437596_3 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000008164 127.0
TLS2_k127_43776_0 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 357.0
TLS2_k127_43776_1 permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 309.0
TLS2_k127_43776_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001177 258.0
TLS2_k127_43776_3 COG2867 Oligoketide cyclase lipid transport protein K18588 - - 0.0000000000000000000000000000000000000000000000000000000001649 208.0
TLS2_k127_43776_4 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.000000000000000000000000000000000000000005114 157.0
TLS2_k127_43776_5 Transcription factor zinc-finger K09981 - - 0.00000000000000000002591 104.0
TLS2_k127_4397527_0 Hydantoinase B/oxoprolinase - - - 4.308e-304 943.0
TLS2_k127_4397527_1 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000172 166.0
TLS2_k127_4400222_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 4.784e-252 790.0
TLS2_k127_4400222_1 Hydantoinase B/oxoprolinase - - - 1.211e-220 691.0
TLS2_k127_4406932_0 Transposase IS66 family K07484 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 328.0
TLS2_k127_4429748_0 type III secretion pore protein K03230 - - 9.072e-278 872.0
TLS2_k127_4429748_1 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.644e-214 668.0
TLS2_k127_4429748_10 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.000000000002857 72.0
TLS2_k127_4429748_11 Tetratricopeptide repeat - - - 0.0000000000145 69.0
TLS2_k127_4429748_12 Inner membrane component of T3SS, cytoplasmic domain K03220 - - 0.0000007985 54.0
TLS2_k127_4429748_2 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008439 380.0
TLS2_k127_4429748_3 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 364.0
TLS2_k127_4429748_4 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000006021 265.0
TLS2_k127_4429748_5 carbonate dehydratase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001042 253.0
TLS2_k127_4429748_6 HrpJ-like domain K04058 - - 0.000000000000000000000002294 116.0
TLS2_k127_4429748_7 - - - - 0.0000000000000002906 86.0
TLS2_k127_4429748_8 protein secretion - - - 0.000000000000004171 87.0
TLS2_k127_4429748_9 Type III secretion system YscX (type_III_YscX) K04059 - - 0.0000000000002058 75.0
TLS2_k127_4443174_0 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 5.585e-210 665.0
TLS2_k127_4443174_1 YcjX-like family, DUF463 K06918 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 447.0
TLS2_k127_4443174_2 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 357.0
TLS2_k127_4443174_3 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 331.0
TLS2_k127_4443174_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 292.0
TLS2_k127_4443174_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000001272 217.0
TLS2_k127_4443174_6 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000002796 169.0
TLS2_k127_4496290_0 PHB/PHA accumulation regulator DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000005632 224.0
TLS2_k127_4496290_1 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000001114 195.0
TLS2_k127_4496290_2 membrane - - - 0.000000000000000000000000000000000008746 148.0
TLS2_k127_4496290_3 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000001199 132.0
TLS2_k127_4496290_4 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.000000000006347 68.0
TLS2_k127_452510_0 Capsule polysaccharide biosynthesis protein K07266 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 574.0
TLS2_k127_452510_1 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 443.0
TLS2_k127_452510_10 sulfur carrier activity K04085 - - 0.000000000000000000000000031 111.0
TLS2_k127_452510_11 Putative prokaryotic signal transducing protein - - - 0.0000000000000002009 84.0
TLS2_k127_452510_12 Ribbon-helix-helix protein, copG family - - - 0.0000002405 55.0
TLS2_k127_452510_2 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 427.0
TLS2_k127_452510_3 Capsule polysaccharide K07265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 314.0
TLS2_k127_452510_4 Peptidase family S49 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005568 283.0
TLS2_k127_452510_5 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000101 268.0
TLS2_k127_452510_6 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001872 256.0
TLS2_k127_452510_7 Domain of unknown function DUF29 - - - 0.0000000000000000000000000000000000000975 147.0
TLS2_k127_452510_8 - - - - 0.0000000000000000000000000002013 130.0
TLS2_k127_452510_9 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000009844 122.0
TLS2_k127_4541297_0 PFAM NnrS family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000134 234.0
TLS2_k127_4541297_1 protein involved in response to NO K07234 - - 0.0000000000000000000000000000000000000000000000000001499 194.0
TLS2_k127_4541297_2 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21563 - - 0.000000000000000000000000000000000000000000000000001402 205.0
TLS2_k127_4543942_0 PFAM binding-protein-dependent transport systems inner membrane component K02054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 322.0
TLS2_k127_4543942_1 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000001505 120.0
TLS2_k127_4543942_2 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000002156 85.0
TLS2_k127_4544967_0 COG1131 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 415.0
TLS2_k127_4544967_1 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 363.0
TLS2_k127_4544967_2 LysR substrate binding domain K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008592 311.0
TLS2_k127_4544967_3 DinB superfamily - - - 0.0000000000000000000000000000000000000000000112 167.0
TLS2_k127_4544967_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000314 167.0
TLS2_k127_4544967_5 Subtilase family - - - 0.00000000000000000000000000000000000003488 148.0
TLS2_k127_4544967_6 - - - - 0.000000000000000000000000002193 119.0
TLS2_k127_4544967_7 Belongs to the peptidase S8 family - - - 0.000000000000000001644 86.0
TLS2_k127_4544967_9 - - - - 0.0000003572 56.0
TLS2_k127_4597292_0 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 552.0
TLS2_k127_4597292_1 Transposase, Mutator family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 518.0
TLS2_k127_4597292_2 PFAM transposase IS3 IS911 family protein K07483 - - 0.0000000000000000000000000000009154 124.0
TLS2_k127_4597292_3 - - - - 0.00000000000002394 81.0
TLS2_k127_4601867_0 Aerotolerance regulator N-terminal - - - 5.278e-270 858.0
TLS2_k127_4601867_1 membrane - - - 1.854e-229 752.0
TLS2_k127_4601867_10 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000009254 211.0
TLS2_k127_4601867_11 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000000000000001701 211.0
TLS2_k127_4601867_12 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 0.00000000000000000000000000000000000000000000000006559 181.0
TLS2_k127_4601867_13 Protein of unknown function (DUF1285) K09986 - - 0.0000000000000000000000000000000000000000000000002129 184.0
TLS2_k127_4601867_14 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000000000005645 97.0
TLS2_k127_4601867_15 BrnA antitoxin of type II toxin-antitoxin system - - - 0.000000000000007633 81.0
TLS2_k127_4601867_16 Belongs to the 'phage' integrase family - - - 0.0000000000004962 72.0
TLS2_k127_4601867_17 - - - - 0.00003994 54.0
TLS2_k127_4601867_18 - - - - 0.000179 54.0
TLS2_k127_4601867_2 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 458.0
TLS2_k127_4601867_3 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate K00899 - 2.7.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008746 407.0
TLS2_k127_4601867_4 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 423.0
TLS2_k127_4601867_5 poly(A) polymerase K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008372 343.0
TLS2_k127_4601867_6 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 316.0
TLS2_k127_4601867_7 Pseudouridine synthase K06177 - 5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 287.0
TLS2_k127_4601867_8 Acts on guanine, xanthine and to a lesser extent hypoxanthine K00769 - 2.4.2.22 0.0000000000000000000000000000000000000000000000000000000000000000000000004624 249.0
TLS2_k127_4601867_9 Endoribonuclease XendoU - - - 0.0000000000000000000000000000000000000000000000000000000000000000001175 242.0
TLS2_k127_4623931_0 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007406 362.0
TLS2_k127_4623931_1 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001248 264.0
TLS2_k127_4623931_2 Metallo-beta-lactamase superfamily - - - 0.000009263 48.0
TLS2_k127_4676140_0 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003404 284.0
TLS2_k127_4676140_1 Exopolysaccharide synthesis, ExoD - - - 0.0000000000000000000000000000000000000000000000004666 187.0
TLS2_k127_4676140_2 Protein conserved in bacteria - - - 0.000000000000000000000001644 113.0
TLS2_k127_4676140_4 CsbD-like - - - 0.00000000000000000003418 90.0
TLS2_k127_4676140_5 Protein of unknown function (DUF3309) - - - 0.00000000000000000009906 93.0
TLS2_k127_4676140_6 - - - - 0.000000000000000002185 92.0
TLS2_k127_4676140_7 GAF domain - - - 0.000000000000002171 87.0
TLS2_k127_4676140_8 Protein of unknown function (DUF3185) - - - 0.000000000000007841 75.0
TLS2_k127_4676140_9 - - - - 0.0000001212 58.0
TLS2_k127_4686662_0 AMP-binding enzyme C-terminal domain K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 601.0
TLS2_k127_4686662_1 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 429.0
TLS2_k127_4686662_2 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000003288 227.0
TLS2_k127_4686662_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000003774 205.0
TLS2_k127_4692405_0 Amidohydrolase family - - - 7.616e-200 629.0
TLS2_k127_4692405_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000172 104.0
TLS2_k127_4706007_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 5.169e-232 726.0
TLS2_k127_4706007_1 Belongs to the P(II) protein family K04751 GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - 0.0000000000000000000000000000000000000000000000000000001505 198.0
TLS2_k127_4706007_3 - - - - 0.000000000004278 76.0
TLS2_k127_4706007_4 Plasmid maintenance system killer K07334 - - 0.000001445 51.0
TLS2_k127_4706588_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008739 565.0
TLS2_k127_4706588_1 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 575.0
TLS2_k127_4706588_2 ubiquitin protein ligase binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 460.0
TLS2_k127_4706588_3 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002134 285.0
TLS2_k127_4706588_4 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008608 271.0
TLS2_k127_4706588_5 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000000001386 164.0
TLS2_k127_4706588_6 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.000000000000000000000000000000000002586 150.0
TLS2_k127_4706588_7 CopG antitoxin of type II toxin-antitoxin system - - - 0.00000000000000000000004999 113.0
TLS2_k127_4706588_8 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000001375 72.0
TLS2_k127_4706588_9 PFAM glycosyl transferase family 2 - - - 0.00000000003513 75.0
TLS2_k127_4706609_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 481.0
TLS2_k127_4707463_0 chromosome segregation - - - 8.712e-201 651.0
TLS2_k127_4707463_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 572.0
TLS2_k127_4707463_10 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000000000000000000002936 113.0
TLS2_k127_4707463_11 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000001183 111.0
TLS2_k127_4707463_12 - - - - 0.0000000000000001052 93.0
TLS2_k127_4707463_13 Cell Wall Hydrolase - - - 0.0000002242 58.0
TLS2_k127_4707463_2 Protein of unknown function (DUF1329) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 518.0
TLS2_k127_4707463_3 Protein of unknown function (DUF1302) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 520.0
TLS2_k127_4707463_4 Amino-transferase class IV - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 457.0
TLS2_k127_4707463_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 382.0
TLS2_k127_4707463_6 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 363.0
TLS2_k127_4707463_7 Belongs to the LDH2 MDH2 oxidoreductase family K00073,K13574 - 1.1.1.350 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004706 288.0
TLS2_k127_4707463_8 ABC transporter K10112 - - 0.00000000000000000000000000000000000000000000000000000000000000000002401 235.0
TLS2_k127_4707463_9 HicB family - - - 0.000000000000000000000000001184 127.0
TLS2_k127_4709489_0 zinc-finger binding domain of transposase IS66 - - - 1.056e-199 637.0
TLS2_k127_4709489_1 IS66 Orf2 like protein - - - 0.00000000000000000000000000000000000000000000000001768 183.0
TLS2_k127_4709489_2 COG2963, Transposase and inactivated derivatives - - - 0.00000000000000000000000000006585 121.0
TLS2_k127_4709489_3 Transposase and inactivated derivatives - - - 0.00000000000000000000001711 100.0
TLS2_k127_4716237_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006093 527.0
TLS2_k127_4716237_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 509.0
TLS2_k127_4716237_2 haemagglutination activity domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008162 271.0
TLS2_k127_4716237_3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000307 229.0
TLS2_k127_4716237_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.0000000000000000000000000000000000000000000000000000000000000003716 227.0
TLS2_k127_4716237_5 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000001564 191.0
TLS2_k127_4716237_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000002689 182.0
TLS2_k127_4716237_7 TIGRFAM addiction module antidote protein, HigA family K21498 - - 0.000000000000000000117 93.0
TLS2_k127_4717136_0 Protein conserved in bacteria K07793 - - 1.292e-204 654.0
TLS2_k127_4717136_1 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000002006 245.0
TLS2_k127_4717136_2 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000008382 102.0
TLS2_k127_4719956_0 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003674 264.0
TLS2_k127_4719956_1 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000006646 125.0
TLS2_k127_4719956_2 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000001012 64.0
TLS2_k127_4725498_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 501.0
TLS2_k127_4725498_1 Binding-protein-dependent transport system inner membrane component K17316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009961 472.0
TLS2_k127_4725498_2 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000000002035 130.0
TLS2_k127_4726409_0 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 5.433e-232 746.0
TLS2_k127_4726409_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 343.0
TLS2_k127_4726409_2 Belongs to the DapA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 293.0
TLS2_k127_4726409_3 threonine efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002286 246.0
TLS2_k127_4726409_4 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.0000001462 62.0
TLS2_k127_4726983_0 ABC-type dipeptide transport system periplasmic component K02035 - - 1.331e-196 619.0
TLS2_k127_4726983_1 COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 4.695e-195 626.0
TLS2_k127_4726983_10 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 302.0
TLS2_k127_4726983_11 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000005121 231.0
TLS2_k127_4726983_12 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000008657 243.0
TLS2_k127_4726983_13 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000000000000000000000000000000000000000000000002575 226.0
TLS2_k127_4726983_14 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000000000000000000003913 168.0
TLS2_k127_4726983_15 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000000000000000000000000001011 172.0
TLS2_k127_4726983_16 Belongs to the BolA IbaG family K05527,K22066 - - 0.000000000000000000000000001689 115.0
TLS2_k127_4726983_17 Dihydroneopterin aldolase - - - 0.0000000000000000000000005015 120.0
TLS2_k127_4726983_18 Protein of unknown function (DUF2442) - - - 0.00000000000000000000004695 102.0
TLS2_k127_4726983_19 Domain of unknown function (DUF4160) - - - 0.0000000000000001622 89.0
TLS2_k127_4726983_2 PFAM AAA domain (dynein-related subfamily) K09882 - 6.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 556.0
TLS2_k127_4726983_20 - - - - 0.000000000000003805 79.0
TLS2_k127_4726983_3 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 538.0
TLS2_k127_4726983_4 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 533.0
TLS2_k127_4726983_5 Amidohydrolase family K05603 - 3.5.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 512.0
TLS2_k127_4726983_6 Proline racemase K12658 - 5.1.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 523.0
TLS2_k127_4726983_7 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 504.0
TLS2_k127_4726983_8 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 480.0
TLS2_k127_4726983_9 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 317.0
TLS2_k127_4733184_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 440.0
TLS2_k127_4733184_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000003116 160.0
TLS2_k127_4733184_2 PFAM PIN domain - - - 0.0000000000000000000003776 104.0
TLS2_k127_4733184_3 positive regulation of growth - - - 0.00000000000000818 84.0
TLS2_k127_4735382_0 Transposase - - - 2.85e-197 625.0
TLS2_k127_4735382_1 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000001437 135.0
TLS2_k127_4741356_0 Glycogen debranching enzyme - - - 6.767e-245 763.0
TLS2_k127_4741356_1 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 569.0
TLS2_k127_4741356_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006506 531.0
TLS2_k127_4741356_3 CHAT domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 300.0
TLS2_k127_4741356_4 - - - - 0.00000000000000000000000000000000000000000376 160.0
TLS2_k127_4741356_5 Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000008221 93.0
TLS2_k127_4741356_6 - - - - 0.00003428 49.0
TLS2_k127_4746891_0 COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit K05559,K05565 - - 0.0 1061.0
TLS2_k127_4746891_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 5.317e-195 614.0
TLS2_k127_4746891_10 methionine biosynthesis protein (MetW) - - - 0.00000000000000000000000000000000000000000000000000000006385 217.0
TLS2_k127_4746891_11 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.00000000000000000000000000000000000000000000000000000008644 202.0
TLS2_k127_4746891_12 Multisubunit Na H antiporter, MnhE subunit K05562 - - 0.00000000000000000000000000000000000000000000000006524 182.0
TLS2_k127_4746891_13 PFAM Na H antiporter subunit K05564 - - 0.00000000000000000000000000000000001143 139.0
TLS2_k127_4746891_14 oxidoreductase, chain 4L K00340,K05560 - 1.6.5.3 0.0000000000000000000000000000000000567 141.0
TLS2_k127_4746891_15 Multiple resistance and pH regulation protein F (MrpF / PhaF) K05563 - - 0.00000000000000000000000007444 121.0
TLS2_k127_4746891_16 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000004275 108.0
TLS2_k127_4746891_17 Cold shock protein domain K03704 - - 0.0000000000000000000000008317 104.0
TLS2_k127_4746891_19 PFAM Glucose Sorbosone dehydrogenase - - - 0.000000000002126 70.0
TLS2_k127_4746891_2 COG0651 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05561,K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 531.0
TLS2_k127_4746891_20 Domain of unknown function (DUF1127) - - - 0.00003139 54.0
TLS2_k127_4746891_3 NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000464 483.0
TLS2_k127_4746891_4 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 464.0
TLS2_k127_4746891_5 Prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 442.0
TLS2_k127_4746891_6 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003416 246.0
TLS2_k127_4746891_7 peroxiredoxin activity K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000003346 232.0
TLS2_k127_4746891_8 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000000001592 221.0
TLS2_k127_4746891_9 chorismate mutase - - - 0.00000000000000000000000000000000000000000000000000000000002212 217.0
TLS2_k127_4748387_0 nitric oxide dioxygenase activity K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 531.0
TLS2_k127_4748387_1 Protein of unknown function (DUF1194) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001428 261.0
TLS2_k127_4748387_2 Protein of unknown function (DUF1194) - - - 0.00000000000000000000000000000000000000000000000000000000000007178 219.0
TLS2_k127_4762082_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 5.673e-220 703.0
TLS2_k127_4762082_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.227e-211 667.0
TLS2_k127_4762082_2 PFAM regulatory protein AsnC Lrp family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006296 247.0
TLS2_k127_4762082_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000004057 180.0
TLS2_k127_4762082_4 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000002674 168.0
TLS2_k127_4768136_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 0.0 1024.0
TLS2_k127_4768136_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 436.0
TLS2_k127_4768136_11 CobQ CobB MinD ParA nucleotide binding domain K03496 - - 0.00002226 57.0
TLS2_k127_4768136_2 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 404.0
TLS2_k127_4768136_3 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005087 281.0
TLS2_k127_4768136_4 Uncharacterized protein conserved in bacteria (DUF2066) - - - 0.000000000000000000000000000000000000000000000000000000000003121 223.0
TLS2_k127_4768136_5 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000006782 194.0
TLS2_k127_4768136_6 - - - - 0.00000000000000000000000000000000000000000000000000002055 201.0
TLS2_k127_4768136_7 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000006167 183.0
TLS2_k127_4768136_8 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.000000000000000000000000000000000001669 149.0
TLS2_k127_4768136_9 Involved in chromosome partitioning K03496 - - 0.000000000000000004784 99.0
TLS2_k127_4768775_0 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 351.0
TLS2_k127_4768775_1 Phospholipid methyltransferase - - - 0.000000000000000000000000000000000000007715 146.0
TLS2_k127_4768775_2 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.0000000000000000000000000004583 127.0
TLS2_k127_4768775_3 - - - - 0.0000000000000000000001547 108.0
TLS2_k127_4769846_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 0.0 1090.0
TLS2_k127_4769846_1 TIGRFAM c-type cytochrome biogenesis protein CcmF K02198 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005253 604.0
TLS2_k127_4769846_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 513.0
TLS2_k127_4769846_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 489.0
TLS2_k127_4769846_4 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000001305 177.0
TLS2_k127_4769846_5 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000004662 166.0
TLS2_k127_4769846_6 invasion associated locus B - - - 0.00000000000000000000000000000000000000001184 163.0
TLS2_k127_4769846_7 ChrR Cupin-like domain K07167 - - 0.0000000000000000000000000000000000000126 153.0
TLS2_k127_4769846_8 Domain of unknown function (DUF1330) - - - 0.0000000000000000004768 90.0
TLS2_k127_4769846_9 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 - - 0.00001726 51.0
TLS2_k127_478414_0 single-stranded-DNA-specific exonuclease recJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 591.0
TLS2_k127_478414_1 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000004421 199.0
TLS2_k127_478414_2 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446,K11532 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000001992 162.0
TLS2_k127_478414_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000005788 146.0
TLS2_k127_4785638_0 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 406.0
TLS2_k127_4785638_1 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000411 158.0
TLS2_k127_4785638_2 NMT1/THI5 like K02051 - - 0.00000000000000000000000000000000002051 137.0
TLS2_k127_4787185_0 Biotin carboxylase C-terminal domain K01965 GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681 6.4.1.3 4.667e-261 819.0
TLS2_k127_4787185_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 5.935e-225 709.0
TLS2_k127_4787185_10 protein tyrosine phosphatase - - - 0.000000000000000000000000000000272 135.0
TLS2_k127_4787185_11 PIN domain K07064 - - 0.00000000000000000000000000199 116.0
TLS2_k127_4787185_12 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000000008817 109.0
TLS2_k127_4787185_13 Winged helix-turn helix - - - 0.0000000000000000000001754 101.0
TLS2_k127_4787185_14 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.00000000000000002572 88.0
TLS2_k127_4787185_15 DDE superfamily endonuclease - - - 0.00000000000000005653 87.0
TLS2_k127_4787185_16 SpoVT / AbrB like domain - - - 0.0000000000000002846 81.0
TLS2_k127_4787185_17 Peptidase propeptide and YPEB domain - - - 0.000000000000001868 78.0
TLS2_k127_4787185_18 positive regulation of growth - - - 0.00000001949 63.0
TLS2_k127_4787185_2 Cysteine-rich domain K11473 - - 3.871e-205 645.0
TLS2_k127_4787185_3 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008833 512.0
TLS2_k127_4787185_4 D-galactarate dehydratase / Altronate hydrolase, C terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 457.0
TLS2_k127_4787185_5 mRNA catabolic process K06950,K09163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003408 265.0
TLS2_k127_4787185_6 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000004803 264.0
TLS2_k127_4787185_7 2-oxohepta-3-ene-1,7-dioic acid hydratase K02509,K02554 - 4.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000003605 250.0
TLS2_k127_4787185_8 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000001352 248.0
TLS2_k127_4787185_9 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000006857 213.0
TLS2_k127_4797097_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 5.749e-242 754.0
TLS2_k127_4797097_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005746 537.0
TLS2_k127_4797097_10 - K18829 - - 0.0000000000000000000000000000000004743 132.0
TLS2_k127_4797097_11 regulatory protein, arsR - - - 0.0000000000000000000000001508 111.0
TLS2_k127_4797097_12 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000004086 105.0
TLS2_k127_4797097_13 protein conserved in bacteria - - - 0.0000000000000004062 82.0
TLS2_k127_4797097_14 PFAM Prokaryotic metallothionein K21904 - - 0.0000000000000167 75.0
TLS2_k127_4797097_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 357.0
TLS2_k127_4797097_3 Sodium/calcium exchanger protein K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006411 346.0
TLS2_k127_4797097_4 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 329.0
TLS2_k127_4797097_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000006532 210.0
TLS2_k127_4797097_6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000000000000000000000000000000006176 188.0
TLS2_k127_4797097_7 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000002024 191.0
TLS2_k127_4797097_8 nucleic acid-binding protein contains PIN domain K18828 - - 0.00000000000000000000000000000000000000000001017 166.0
TLS2_k127_4797097_9 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000001939 138.0
TLS2_k127_4797797_0 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000001421 254.0
TLS2_k127_4797797_1 von Willebrand factor type A domain K07114 - - 0.000000000000001415 88.0
TLS2_k127_4797797_2 - - - - 0.000000000000002061 85.0
TLS2_k127_4802484_0 Aminotransferase K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 597.0
TLS2_k127_4802484_1 ABC transporter, substrate-binding protein, family 5 K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 554.0
TLS2_k127_4802484_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 557.0
TLS2_k127_4802484_3 Chain length determinant protein K16554 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 443.0
TLS2_k127_4802484_4 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000008623 216.0
TLS2_k127_4802484_5 Alpha/beta hydrolase family K01048 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000006681 219.0
TLS2_k127_4802484_6 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000001252 160.0
TLS2_k127_4812765_0 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 8.397e-210 670.0
TLS2_k127_4812765_1 Reverse transcriptase (RNA-dependent DNA polymerase) - - - 0.00000000000001262 81.0
TLS2_k127_4812765_2 Nucleotidyltransferase domain K07075 - - 0.00001443 53.0
TLS2_k127_4827248_0 Succinyl-CoA ligase like flavodoxin domain - - - 0.0 1041.0
TLS2_k127_4827248_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.487e-276 891.0
TLS2_k127_4827248_10 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000007048 270.0
TLS2_k127_4827248_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07774 - - 0.000000000000000000000000000000000000000000000000000000000000000009096 231.0
TLS2_k127_4827248_12 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000000000000007978 176.0
TLS2_k127_4827248_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000002714 134.0
TLS2_k127_4827248_14 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000001436 106.0
TLS2_k127_4827248_15 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000007433 106.0
TLS2_k127_4827248_16 Septum formation initiator - - - 0.0000000000004774 78.0
TLS2_k127_4827248_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.964e-265 829.0
TLS2_k127_4827248_3 ATP citrate lyase citrate-binding - - - 7.948e-227 726.0
TLS2_k127_4827248_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 8.111e-199 636.0
TLS2_k127_4827248_5 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 602.0
TLS2_k127_4827248_6 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 407.0
TLS2_k127_4827248_7 YmdB-like protein K09769 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 362.0
TLS2_k127_4827248_8 Histidine kinase K07644,K07649 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 307.0
TLS2_k127_4827248_9 Sugar (and other) transporter K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004573 302.0
TLS2_k127_4836091_0 Bacterial extracellular solute-binding protein K02027 - - 1.209e-226 710.0
TLS2_k127_4836091_1 AP endonuclease family 2 C terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 574.0
TLS2_k127_4836091_10 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 328.0
TLS2_k127_4836091_11 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007294 256.0
TLS2_k127_4836091_12 BON domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001267 237.0
TLS2_k127_4836091_13 17 kDa outer membrane surface antigen - - - 0.000000000000000000000000000000000000003755 158.0
TLS2_k127_4836091_14 Hsp20/alpha crystallin family - - - 0.00000000000000000000000000000000001695 139.0
TLS2_k127_4836091_15 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000002799 136.0
TLS2_k127_4836091_16 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000001006 128.0
TLS2_k127_4836091_17 - - - - 0.0000000001665 74.0
TLS2_k127_4836091_18 surface antigen - - - 0.00002905 52.0
TLS2_k127_4836091_19 Formate nitrite K06212 - - 0.0006591 45.0
TLS2_k127_4836091_2 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002707 522.0
TLS2_k127_4836091_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 487.0
TLS2_k127_4836091_4 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 464.0
TLS2_k127_4836091_5 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007113 459.0
TLS2_k127_4836091_6 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 455.0
TLS2_k127_4836091_7 COG3839 ABC-type sugar transport systems ATPase components K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000963 443.0
TLS2_k127_4836091_8 MotA TolQ ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004565 417.0
TLS2_k127_4836091_9 flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 354.0
TLS2_k127_4842499_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009269 493.0
TLS2_k127_4842499_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 383.0
TLS2_k127_4842499_2 Glycosyl transferases group 1 - - - 0.0000004079 62.0
TLS2_k127_4846312_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 355.0
TLS2_k127_4846312_1 Domain of unknown function (DUF1998) - - - 0.000000000000000000000000000000000000000000000000000000000000000199 227.0
TLS2_k127_4846312_2 Transposase - - - 0.00000003371 58.0
TLS2_k127_4854363_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.347e-220 699.0
TLS2_k127_4854363_1 Signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 391.0
TLS2_k127_4854363_2 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 319.0
TLS2_k127_4854363_3 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001268 246.0
TLS2_k127_4854363_4 type I secretion membrane fusion protein, HlyD family K02022,K11003 - - 0.0000000000000000000000000000000154 130.0
TLS2_k127_4854363_5 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000006257 123.0
TLS2_k127_4854363_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000008167 103.0
TLS2_k127_4854363_7 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000009165 103.0
TLS2_k127_4854363_8 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000001421 74.0
TLS2_k127_4893376_0 Receptor family ligand binding region K01999 - - 1.189e-213 670.0
TLS2_k127_4893376_1 Beta-lactamase K18372 - - 1.696e-200 632.0
TLS2_k127_4893376_10 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000000000000003983 179.0
TLS2_k127_4893376_11 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.000000000000000000000000000000000000000000006888 168.0
TLS2_k127_4893376_12 - - - - 0.000000000000000000000000000000000009886 143.0
TLS2_k127_4893376_13 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000000000001654 137.0
TLS2_k127_4893376_14 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000000002958 131.0
TLS2_k127_4893376_15 AMP binding - - - 0.000000000000000000000000000000005369 139.0
TLS2_k127_4893376_16 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.000000000000000000001185 100.0
TLS2_k127_4893376_18 transduction histidine kinase K07716 - 2.7.13.3 0.000000001558 68.0
TLS2_k127_4893376_19 Phasin protein - - - 0.00000005765 59.0
TLS2_k127_4893376_2 Belongs to the ClpA ClpB family K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 580.0
TLS2_k127_4893376_20 FecR protein - - - 0.00007838 54.0
TLS2_k127_4893376_3 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 473.0
TLS2_k127_4893376_4 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 414.0
TLS2_k127_4893376_5 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 379.0
TLS2_k127_4893376_6 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 346.0
TLS2_k127_4893376_7 Domain of unknown function DUF108 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 300.0
TLS2_k127_4893376_8 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 286.0
TLS2_k127_4893376_9 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001925 294.0
TLS2_k127_4894440_0 Phosphopantetheine attachment site - - - 0.0 1540.0
TLS2_k127_4894440_1 Adenylate - - - 0.0 1053.0
TLS2_k127_4894440_10 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0002559 46.0
TLS2_k127_4894440_2 ABC transporter (Periplasmic binding protein) K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 393.0
TLS2_k127_4894440_3 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 309.0
TLS2_k127_4894440_4 Terminase K21512 - 3.1.21.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001086 270.0
TLS2_k127_4894440_5 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000009154 267.0
TLS2_k127_4894440_6 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.000000000000000000000001992 112.0
TLS2_k127_4894440_7 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.00000000000146 80.0
TLS2_k127_4894440_8 - - - - 0.0000001442 61.0
TLS2_k127_4894440_9 - - - - 0.000003845 55.0
TLS2_k127_4903899_0 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 398.0
TLS2_k127_4903899_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 383.0
TLS2_k127_4903899_2 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000004889 152.0
TLS2_k127_4906421_0 LVIVD repeat - - - 0.0 1724.0
TLS2_k127_4906421_1 - - - - 1.501e-219 701.0
TLS2_k127_4906421_10 COG1522 Transcriptional regulators - - - 0.000000000000000000000000000001013 137.0
TLS2_k127_4906421_11 histone H2A K63-linked ubiquitination - - - 0.00000000000000000004668 104.0
TLS2_k127_4906421_12 UPF0391 membrane protein - - - 0.0000000000008812 69.0
TLS2_k127_4906421_13 - - - - 0.000001606 59.0
TLS2_k127_4906421_2 DEAD-like helicases superfamily K03732,K11927 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 504.0
TLS2_k127_4906421_3 CHASE2 K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 359.0
TLS2_k127_4906421_4 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000001089 237.0
TLS2_k127_4906421_5 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000003743 222.0
TLS2_k127_4906421_6 Haem-degrading - - - 0.000000000000000000000000000000000000000000000000000001375 195.0
TLS2_k127_4906421_7 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.00000000000000000000000000000000000000000000000000003855 201.0
TLS2_k127_4906421_8 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000009121 189.0
TLS2_k127_4906421_9 ETC complex I subunit conserved region K00329 - 1.6.5.3 0.000000000000000000000000000000000000004576 147.0
TLS2_k127_4906605_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 401.0
TLS2_k127_4906605_1 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 376.0
TLS2_k127_4906605_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 322.0
TLS2_k127_4906605_3 GMC oxidoreductase - - - 0.000000000000002689 76.0
TLS2_k127_4921400_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.19e-254 803.0
TLS2_k127_4921400_1 3-hydroxyacyl-CoA dehydrogenase K00074,K07516 - 1.1.1.157,1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 452.0
TLS2_k127_4921400_2 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003849 426.0
TLS2_k127_4921400_3 electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007187 402.0
TLS2_k127_4921400_4 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 376.0
TLS2_k127_4921400_5 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000004757 213.0
TLS2_k127_4921400_6 Domain of unknown function (DUF4214) - - - 0.0000000000000000000000000000000000000000000000000000008974 216.0
TLS2_k127_4921400_7 cell wall hydrolase K01449 - 3.5.1.28 0.000000000000000000000000000000001509 136.0
TLS2_k127_4921400_8 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000002251 133.0
TLS2_k127_4926646_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1093.0
TLS2_k127_4926646_1 COG0402 Cytosine deaminase and related metal-dependent hydrolases K01485 - 3.5.4.1 8.751e-194 629.0
TLS2_k127_4926646_10 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 320.0
TLS2_k127_4926646_11 PFAM IstB domain protein ATP-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001011 252.0
TLS2_k127_4926646_12 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001328 263.0
TLS2_k127_4926646_13 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000002729 238.0
TLS2_k127_4926646_14 RNase H K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000004427 213.0
TLS2_k127_4926646_15 Putative Flp pilus-assembly TadE/G-like - - - 0.00000000000000000000000000000000000000000000000000005134 206.0
TLS2_k127_4926646_16 Redoxin K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000002209 180.0
TLS2_k127_4926646_17 - - - - 0.000000000006347 68.0
TLS2_k127_4926646_18 TadE-like protein - - - 0.000001979 56.0
TLS2_k127_4926646_19 Resolvase, N terminal domain - - - 0.0002187 46.0
TLS2_k127_4926646_2 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 462.0
TLS2_k127_4926646_3 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 451.0
TLS2_k127_4926646_4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 444.0
TLS2_k127_4926646_5 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 428.0
TLS2_k127_4926646_6 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 414.0
TLS2_k127_4926646_7 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 370.0
TLS2_k127_4926646_8 Amino-transferase class IV K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 347.0
TLS2_k127_4926646_9 PFAM ABC transporter K02056 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 330.0
TLS2_k127_4941235_0 FAD linked oxidases, C-terminal domain K18930 - - 2.592e-282 881.0
TLS2_k127_4941235_1 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 364.0
TLS2_k127_494805_0 chaperone-mediated protein folding K02660,K03466,K07474,K19175 - - 5.253e-203 683.0
TLS2_k127_494805_1 Belongs to the peptidase S1B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 479.0
TLS2_k127_494805_10 Radical SAM superfamily K06871 - - 0.0000000000000000000000000000001396 134.0
TLS2_k127_494805_2 Zinc-dependent metalloprotease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 407.0
TLS2_k127_494805_3 WD domain, G-beta repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 431.0
TLS2_k127_494805_4 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 300.0
TLS2_k127_494805_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003775 274.0
TLS2_k127_494805_6 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000126 228.0
TLS2_k127_494805_7 Involved in initiation control of chromosome replication K07484 - - 0.00000000000000000000000000000000000000000000000000000002894 204.0
TLS2_k127_494805_8 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000006862 183.0
TLS2_k127_494805_9 TIGRFAM outer membrane autotransporter barrel - - - 0.000000000000000000000000000000002202 139.0
TLS2_k127_4966818_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 9.864e-231 729.0
TLS2_k127_4966818_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 429.0
TLS2_k127_4966818_2 PAS fold K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000001911 165.0
TLS2_k127_4966818_3 Transposase - - - 0.00000000000000000000000002201 112.0
TLS2_k127_4966818_4 PFAM Glycoside hydrolase 15-related - - - 0.0000000000000000000000336 109.0
TLS2_k127_4971413_0 Male sterility protein K12454 - 5.1.3.10 4.818e-244 776.0
TLS2_k127_4971413_1 B12 binding domain - - - 3.674e-202 638.0
TLS2_k127_4971413_2 GDP-mannose 4,6 dehydratase K17947 - 5.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 475.0
TLS2_k127_4971413_3 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 407.0
TLS2_k127_4971413_4 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 315.0
TLS2_k127_4971413_5 COG4235 Cytochrome c biogenesis factor K02200 - - 0.000000000000000000000000000000000000000000000000000005928 208.0
TLS2_k127_4971413_6 Domain of unknown function (DUF892) - - - 0.000000000000000000000000000000000000000002167 164.0
TLS2_k127_4971413_7 Integrin alpha (beta-propellor repeats). - - - 0.00000000003915 77.0
TLS2_k127_4975195_0 short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 516.0
TLS2_k127_4975195_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008621 410.0
TLS2_k127_4975195_2 - - - - 0.000000000000000000000000000001842 126.0
TLS2_k127_4975195_3 Multidrug Resistance protein K03297 - - 0.000000000000000000005986 99.0
TLS2_k127_4975195_4 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000002132 58.0
TLS2_k127_4980023_0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 430.0
TLS2_k127_4980023_1 PFAM Glycine sarcosine betaine reductase component B subunits - - - 0.00000000000000000001287 98.0
TLS2_k127_4985727_0 COG2217 Cation transport ATPase K17686 - 3.6.3.54 5.802e-312 996.0
TLS2_k127_4985727_1 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 374.0
TLS2_k127_4985727_2 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000611 320.0
TLS2_k127_4985727_3 Alpha-amylase domain K01187 - 3.2.1.20 0.000000000000000000000000000000000000000000000000000000000009486 216.0
TLS2_k127_4985727_4 MerR, DNA binding - - - 0.000000000000000000000000000000000000000000000003865 179.0
TLS2_k127_4985727_5 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000002969 134.0
TLS2_k127_4985727_6 Short C-terminal domain K08982 - - 0.0000000000000000000000446 103.0
TLS2_k127_4985727_7 - - - - 0.00000000003704 70.0
TLS2_k127_4986049_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 604.0
TLS2_k127_4986049_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 575.0
TLS2_k127_4986049_2 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 374.0
TLS2_k127_4986049_3 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006799 338.0
TLS2_k127_4986049_4 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 302.0
TLS2_k127_4986049_5 PPIC-type PPIASE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002292 235.0
TLS2_k127_4986049_6 Cysteine rich repeat - - - 0.00000000000000000000000000000000002734 140.0
TLS2_k127_4986049_7 Patatin-like phospholipase - - - 0.000000000000000000001561 99.0
TLS2_k127_4986049_8 Belongs to the ompA family - - - 0.000000000000000005974 93.0
TLS2_k127_4989864_0 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 408.0
TLS2_k127_4989864_1 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 355.0
TLS2_k127_4989864_2 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 361.0
TLS2_k127_4989864_3 Belongs to the RtcB family K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003979 282.0
TLS2_k127_4989864_4 Periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000001355 205.0
TLS2_k127_4989864_5 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0000000000000000000000000004406 118.0
TLS2_k127_4989864_6 Domain of unknown function (DUF4440) - - - 0.000000000000000000000000001324 128.0
TLS2_k127_4989864_7 - - - - 0.000000000000000000000005637 104.0
TLS2_k127_4989864_8 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0000000000000005473 85.0
TLS2_k127_4989864_9 - - - - 0.000000000003723 76.0
TLS2_k127_4991716_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 1.606e-248 777.0
TLS2_k127_4991716_1 4-alpha-glucanotransferase - - - 5.061e-230 727.0
TLS2_k127_4991716_2 4-alpha-glucanotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006167 602.0
TLS2_k127_5006494_0 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 2.441e-223 699.0
TLS2_k127_5006494_1 radical SAM domain protein K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 578.0
TLS2_k127_5006494_10 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.00000000000000000000000000000000000000000000000000000000000000000000000005147 269.0
TLS2_k127_5006494_11 Aldolase K01631 - 4.1.2.21 0.00000000000000000000000000000000000000000000000000000000000000000003744 243.0
TLS2_k127_5006494_12 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000000000001618 209.0
TLS2_k127_5006494_13 Transcription elongation factor, GreA/GreB, C-term - - - 0.00000000000000000000000000000000000000001874 175.0
TLS2_k127_5006494_14 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000000000132 162.0
TLS2_k127_5006494_15 ROS/MUCR transcriptional regulator protein - - - 0.000000000000000000000000000000001819 138.0
TLS2_k127_5006494_16 PIN domain - - - 0.000000000000000000000000000000003357 132.0
TLS2_k127_5006494_17 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000002289 143.0
TLS2_k127_5006494_18 toxin-antitoxin pair type II binding - - - 0.000000000000000000000005385 104.0
TLS2_k127_5006494_19 Membrane K08989 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000004839 80.0
TLS2_k127_5006494_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 565.0
TLS2_k127_5006494_20 COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000000000008246 75.0
TLS2_k127_5006494_21 - - - - 0.00000000384 65.0
TLS2_k127_5006494_22 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000002624 57.0
TLS2_k127_5006494_3 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 550.0
TLS2_k127_5006494_4 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 517.0
TLS2_k127_5006494_5 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 474.0
TLS2_k127_5006494_6 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 391.0
TLS2_k127_5006494_7 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 357.0
TLS2_k127_5006494_8 Tricorn protease homolog K08676 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 338.0
TLS2_k127_5006494_9 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 321.0
TLS2_k127_5018411_0 Phage plasmid primase P4 family K06919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 457.0
TLS2_k127_5018411_1 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009755 408.0
TLS2_k127_5018411_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001808 243.0
TLS2_k127_5018411_3 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000001762 213.0
TLS2_k127_5018411_4 Staphylococcal nuclease homologue - - - 0.000000000000000000000000000000000000000008335 164.0
TLS2_k127_5018411_5 Phage plasmid primase P4 family K06919 - - 0.0000000000006871 80.0
TLS2_k127_503995_0 malic enzyme K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 534.0
TLS2_k127_503995_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000716 241.0
TLS2_k127_5056446_0 Glycosyl hydrolase family 65, N-terminal domain - - - 2.195e-298 930.0
TLS2_k127_5056446_1 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 400.0
TLS2_k127_5056446_2 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 363.0
TLS2_k127_5056446_3 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000008683 231.0
TLS2_k127_5056446_4 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000002134 219.0
TLS2_k127_5056446_5 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000000000004475 150.0
TLS2_k127_5056446_6 Rhodanese Homology Domain - - - 0.0000000000000000000000001378 109.0
TLS2_k127_5056446_7 protein conserved in bacteria K09991 - - 0.0000000000000000000001336 106.0
TLS2_k127_5056446_8 - - - - 0.00000000004947 66.0
TLS2_k127_5062851_0 FAD dependent oxidoreductase - - - 1.434e-209 661.0
TLS2_k127_5062851_1 Polysaccharide pyruvyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000946 488.0
TLS2_k127_5062851_2 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000646 104.0
TLS2_k127_5062851_3 permease - - - 0.000000002576 62.0
TLS2_k127_5065140_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 6.787e-227 713.0
TLS2_k127_5065140_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000001971 203.0
TLS2_k127_5077084_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1435.0
TLS2_k127_5077084_1 4Fe-4S dicluster domain K00124,K21308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000401 416.0
TLS2_k127_5077084_10 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.000000000000001203 78.0
TLS2_k127_5077084_2 DMSO reductase anchor subunit (DmsC) K21309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 322.0
TLS2_k127_5077084_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001282 270.0
TLS2_k127_5077084_4 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000001256 183.0
TLS2_k127_5077084_5 Uncharacterized protein conserved in bacteria (DUF2076) K09945 - - 0.0000000000000000000000000000000000003771 147.0
TLS2_k127_5077084_6 transcriptional regulators K22042 - - 0.00000000000000000000000000000000006157 138.0
TLS2_k127_5077084_7 PIN domain - - - 0.00000000000000000000001238 105.0
TLS2_k127_5077084_8 transcriptional regulator K07172 - - 0.0000000000000000003279 94.0
TLS2_k127_5081167_0 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 608.0
TLS2_k127_5081167_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 570.0
TLS2_k127_5081167_10 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000008329 230.0
TLS2_k127_5081167_11 YjbR - - - 0.00000000000000000000000000000000000000000000000000000000001002 207.0
TLS2_k127_5081167_12 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000000000000000000000003136 174.0
TLS2_k127_5081167_13 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000001831 144.0
TLS2_k127_5081167_14 - - - - 0.00000000000000000000000000000003291 130.0
TLS2_k127_5081167_15 FR47-like protein - - - 0.0000000000000000000000000001032 120.0
TLS2_k127_5081167_16 amino acid ABC transporter K01996 - - 0.00000000000000000000000001678 109.0
TLS2_k127_5081167_18 - - - - 0.000000000001563 70.0
TLS2_k127_5081167_19 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.0004157 50.0
TLS2_k127_5081167_2 FAD binding domain K00481 - 1.14.13.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006486 523.0
TLS2_k127_5081167_3 Psort location Cytoplasmic, score 7.50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 494.0
TLS2_k127_5081167_4 amino acid K01999,K11954 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 442.0
TLS2_k127_5081167_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 404.0
TLS2_k127_5081167_6 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 364.0
TLS2_k127_5081167_7 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 350.0
TLS2_k127_5081167_8 Belongs to the MT-A70-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 302.0
TLS2_k127_5081167_9 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000001188 218.0
TLS2_k127_5082053_0 Dehydrogenase - - - 0.0 1024.0
TLS2_k127_5082053_1 Cobalamin synthesis protein cobW C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 359.0
TLS2_k127_5082053_2 COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D K01424 - 3.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 325.0
TLS2_k127_5082053_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005235 270.0
TLS2_k127_5082053_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000006657 216.0
TLS2_k127_5082053_5 Putative lumazine-binding - - - 0.00000000000000000000000000000000000007293 148.0
TLS2_k127_5082053_6 - - - - 0.000000000000000000000039 109.0
TLS2_k127_5082053_7 - - - - 0.000000000000000000000105 110.0
TLS2_k127_5082053_8 Cytochrome c mono- and diheme variants - - - 0.0000000000000000003214 96.0
TLS2_k127_5086854_0 DNA polymerase K02337 - 2.7.7.7 0.0 1303.0
TLS2_k127_5086854_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 4.92e-203 642.0
TLS2_k127_5086854_10 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005641 266.0
TLS2_k127_5086854_11 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003808 244.0
TLS2_k127_5086854_12 Cytidylyltransferase family K00981 - 2.7.7.41 0.000000000000000000000000000000000000000000000000000001396 203.0
TLS2_k127_5086854_13 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000008959 167.0
TLS2_k127_5086854_14 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.000000000000000000000000000000003996 132.0
TLS2_k127_5086854_2 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 489.0
TLS2_k127_5086854_3 COG4591 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 498.0
TLS2_k127_5086854_4 Cation transport protein K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003709 483.0
TLS2_k127_5086854_5 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 472.0
TLS2_k127_5086854_6 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 383.0
TLS2_k127_5086854_7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 363.0
TLS2_k127_5086854_8 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 327.0
TLS2_k127_5086854_9 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 295.0
TLS2_k127_5090197_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 597.0
TLS2_k127_5090197_1 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001479 244.0
TLS2_k127_5091052_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 5e-323 997.0
TLS2_k127_5091052_1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 1.833e-321 994.0
TLS2_k127_5091052_10 HicB family - - - 0.000000000000000000000006972 104.0
TLS2_k127_5091052_12 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000007841 78.0
TLS2_k127_5091052_14 SpoVT / AbrB like domain K07172 - - 0.0003196 46.0
TLS2_k127_5091052_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 2.9e-283 877.0
TLS2_k127_5091052_3 Sugar (and other) transporter K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 532.0
TLS2_k127_5091052_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 494.0
TLS2_k127_5091052_5 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 412.0
TLS2_k127_5091052_6 Belongs to the carbohydrate kinase PfkB family K00882,K00917,K16370 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046835,GO:0071704 2.7.1.11,2.7.1.144,2.7.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003022 368.0
TLS2_k127_5091052_7 PFAM secretion protein HlyD family protein K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002313 343.0
TLS2_k127_5091052_8 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000001547 166.0
TLS2_k127_5091052_9 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000000000000000002526 115.0
TLS2_k127_5093280_0 Transposase domain (DUF772) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008216 552.0
TLS2_k127_5093280_1 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000011 267.0
TLS2_k127_5093280_2 Transposase - - - 0.00000000000001304 79.0
TLS2_k127_5100078_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 8.936e-203 638.0
TLS2_k127_5100078_1 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 422.0
TLS2_k127_5100078_10 Alpha/beta hydrolase family K06999 - - 0.0000000000000000000000000000000000000000000000000004174 199.0
TLS2_k127_5100078_11 SpoU rRNA Methylase family K03216 - 2.1.1.207 0.000000000000000000000000000000000000000006485 159.0
TLS2_k127_5100078_12 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000002141 163.0
TLS2_k127_5100078_13 Histidine kinase - - - 0.000000000000000000000000000000000000003718 167.0
TLS2_k127_5100078_14 Cupin domain - - - 0.0000000000000000000000000000004748 127.0
TLS2_k127_5100078_15 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.000000000000000000000001326 103.0
TLS2_k127_5100078_16 - - - - 0.0000000000004931 79.0
TLS2_k127_5100078_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 347.0
TLS2_k127_5100078_3 Cytochrome C1 family K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 306.0
TLS2_k127_5100078_4 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006633 273.0
TLS2_k127_5100078_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003502 268.0
TLS2_k127_5100078_6 O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004187 272.0
TLS2_k127_5100078_7 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002164 256.0
TLS2_k127_5100078_8 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000071 213.0
TLS2_k127_5100078_9 PFAM Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000001599 197.0
TLS2_k127_510691_0 Carbohydrate ABC transporter substrate-binding protein, CUT1 family K02027 - - 1.949e-245 767.0
TLS2_k127_510691_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 5.999e-196 626.0
TLS2_k127_510691_2 Protein of unknown function (DUF521) K09123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 502.0
TLS2_k127_510691_3 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004167 426.0
TLS2_k127_510691_4 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003059 279.0
TLS2_k127_510691_5 transport system, small permease component - - - 0.0000000000000000000000000000000000000000000000000000009552 196.0
TLS2_k127_5130622_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 6.91e-226 709.0
TLS2_k127_5130622_1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 4.83e-206 659.0
TLS2_k127_5130622_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000005986 236.0
TLS2_k127_5130622_3 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000319 182.0
TLS2_k127_5130622_4 PFAM Integrase catalytic region K07497 - - 0.0000000000000000000000000000000000002825 144.0
TLS2_k127_5130622_5 PFAM Integrase catalytic region K07497 - - 0.000003583 49.0
TLS2_k127_5130622_6 Transposase K07483 - - 0.00009549 48.0
TLS2_k127_5132018_0 symporter activity K03307 - - 3.548e-282 886.0
TLS2_k127_5132018_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000001489 176.0
TLS2_k127_5132018_3 - - - - 0.00004851 50.0
TLS2_k127_5136936_0 TRAP transporter, 4TM 12TM fusion protein - - - 4.482e-287 899.0
TLS2_k127_5136936_1 Gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 543.0
TLS2_k127_5136936_2 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000236 441.0
TLS2_k127_5136936_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 421.0
TLS2_k127_5136936_4 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000001387 247.0
TLS2_k127_5136936_5 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000002609 161.0
TLS2_k127_5136936_6 Monooxygenase fad-binding protein - - - 0.00001643 49.0
TLS2_k127_5159425_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.519e-216 679.0
TLS2_k127_5190952_0 Belongs to the CarB family K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 562.0
TLS2_k127_5190952_1 Belongs to the CarA family K01956 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 526.0
TLS2_k127_5190952_2 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 393.0
TLS2_k127_5190952_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 293.0
TLS2_k127_5190952_4 Yqey-like protein K09117 - - 0.00000000000000000000000000000000001917 141.0
TLS2_k127_5190952_5 Psort location Cytoplasmic, score 8.96 - - - 0.00000000000000000000000000000000002347 138.0
TLS2_k127_5195266_0 Catalyzes the synthesis of activated sulfate K00955 - 2.7.1.25,2.7.7.4 1.951e-277 868.0
TLS2_k127_5195266_1 sulfate adenylyltransferase (ATP) activity K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 420.0
TLS2_k127_5199399_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 5.781e-214 669.0
TLS2_k127_5199399_1 Sodium:alanine symporter family K03310 - - 2.388e-210 670.0
TLS2_k127_5199399_10 PFAM Auxin Efflux Carrier K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001583 252.0
TLS2_k127_5199399_11 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005667 248.0
TLS2_k127_5199399_12 Polysaccharide biosynthesis/export protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001643 241.0
TLS2_k127_5199399_13 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005725 245.0
TLS2_k127_5199399_14 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000000000000000000000000001591 164.0
TLS2_k127_5199399_15 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000000000000000000000187 155.0
TLS2_k127_5199399_16 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000003922 132.0
TLS2_k127_5199399_17 Polymer-forming cytoskeletal - - - 0.0000000000000000000000000000001359 140.0
TLS2_k127_5199399_18 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000002143 106.0
TLS2_k127_5199399_19 positive regulation of growth - - - 0.000000000000000003163 86.0
TLS2_k127_5199399_2 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 3.277e-206 655.0
TLS2_k127_5199399_20 HicA toxin of bacterial toxin-antitoxin, - - - 0.0000000000000003374 79.0
TLS2_k127_5199399_21 Domain of unknown function (DUF1902) - - - 0.000000000005048 73.0
TLS2_k127_5199399_22 Phage shock protein A - - - 0.00000004015 64.0
TLS2_k127_5199399_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 445.0
TLS2_k127_5199399_4 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 358.0
TLS2_k127_5199399_5 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 341.0
TLS2_k127_5199399_6 Belongs to the DapA family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 329.0
TLS2_k127_5199399_7 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 323.0
TLS2_k127_5199399_8 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002293 309.0
TLS2_k127_5199399_9 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001281 268.0
TLS2_k127_5203033_0 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 6.581e-215 677.0
TLS2_k127_5203033_1 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 445.0
TLS2_k127_5203033_2 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 441.0
TLS2_k127_5203033_3 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 345.0
TLS2_k127_5203033_4 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 304.0
TLS2_k127_5203033_5 Membrane protein involved in the export of O-antigen and teichoic acid K03328 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 297.0
TLS2_k127_5203033_6 HicB_like antitoxin of bacterial toxin-antitoxin system - - - 0.00000000000000000000000002068 113.0
TLS2_k127_5203033_7 Domain of unknown function (DUF4170) - - - 0.000000000000000000000007915 119.0
TLS2_k127_5203033_8 EAL domain - - - 0.0000000000000000000002322 111.0
TLS2_k127_5203033_9 PFAM YcfA family protein - - - 0.0000000000000003361 81.0
TLS2_k127_5226300_0 Elongation factor G, domain IV K02355 - - 1.929e-268 854.0
TLS2_k127_5226300_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007059 333.0
TLS2_k127_5247000_0 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 1.633e-313 974.0
TLS2_k127_5247000_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 1.826e-238 747.0
TLS2_k127_5247000_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 6.142e-206 645.0
TLS2_k127_5247000_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331,K03940 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009277 312.0
TLS2_k127_5247000_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004534 307.0
TLS2_k127_5247000_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 296.0
TLS2_k127_5247000_6 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334,K03943 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001193 282.0
TLS2_k127_5247000_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000009216 209.0
TLS2_k127_5247000_8 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000003241 160.0
TLS2_k127_5247000_9 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000000533 119.0
TLS2_k127_5251523_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005485 485.0
TLS2_k127_5251523_1 - - - - 0.0000000001754 65.0
TLS2_k127_5251586_0 Flavin containing amine oxidoreductase K00466 - 1.13.12.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 584.0
TLS2_k127_5251586_1 COG0010 Arginase agmatinase formimionoglutamate hydrolase, arginase family K18459 - 3.5.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 472.0
TLS2_k127_5251586_2 ABC 3 transport family K02075,K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005058 326.0
TLS2_k127_5251586_3 Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system K02074,K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 326.0
TLS2_k127_5251586_4 Belongs to the Fur family K09823 - - 0.00000000000000000000000000000000000000000000000006734 183.0
TLS2_k127_5251586_5 Helix-turn-helix K21498 - - 0.000000000000000000000000000000000009483 138.0
TLS2_k127_5251586_6 - - - - 0.000000134 60.0
TLS2_k127_5309629_0 His Kinase A (phosphoacceptor) domain - - - 1.077e-254 822.0
TLS2_k127_5309629_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 424.0
TLS2_k127_5309629_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 368.0
TLS2_k127_5309629_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 338.0
TLS2_k127_5309629_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001251 246.0
TLS2_k127_5309629_5 ABC-type branched-chain amino acid transport K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000694 231.0
TLS2_k127_5309629_6 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000003999 182.0
TLS2_k127_5309629_7 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000001431 139.0
TLS2_k127_5352166_0 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 481.0
TLS2_k127_5352166_1 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 381.0
TLS2_k127_5352166_2 PFAM Methyltransferase type - - - 0.00000000000000000000000000000000000000000000000000000000000005048 220.0
TLS2_k127_5352166_3 Domain of unknown function (DUF4168) - - - 0.0000000001598 69.0
TLS2_k127_5363013_0 Protocatechuate 3,4-dioxygenase beta subunit N terminal K00449 - 1.13.11.3 0.000000000000000000000000000000000000000000000000000000000000000001029 235.0
TLS2_k127_5363013_1 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000002464 173.0
TLS2_k127_5363013_2 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.00000000000000000000000000000000000000002192 157.0
TLS2_k127_5389532_0 COG4584 Transposase and inactivated derivatives - - - 4.653e-258 803.0
TLS2_k127_5389532_1 IstB-like ATP binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 421.0
TLS2_k127_5389532_2 Cytochrome P460 - - - 0.00000000000000000000000384 101.0
TLS2_k127_5402763_0 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 355.0
TLS2_k127_5402763_1 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 325.0
TLS2_k127_5402763_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000494 272.0
TLS2_k127_5402763_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003674 264.0
TLS2_k127_5402763_4 Bacterial extracellular solute-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000727 259.0
TLS2_k127_5402763_5 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.0000000000000002314 91.0
TLS2_k127_5402763_6 Putative cyclase - - - 0.0000000426 57.0
TLS2_k127_54082_0 COG4584 Transposase and inactivated derivatives - - - 0.00000000000000000000007063 100.0
TLS2_k127_54082_1 membrane protein, terc - - - 0.000000000000000000003607 95.0
TLS2_k127_54082_2 Helix-hairpin-helix motif K02237 - - 0.0000000001499 71.0
TLS2_k127_5441770_0 N-6 DNA Methylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 415.0
TLS2_k127_5441770_1 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 419.0
TLS2_k127_5441770_10 PIN domain - - - 0.000000000000000000000000001725 119.0
TLS2_k127_5441770_11 Transcription regulator of the Arc MetJ class - - - 0.000000000007246 67.0
TLS2_k127_5441770_12 - - - - 0.0002844 47.0
TLS2_k127_5441770_2 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 379.0
TLS2_k127_5441770_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 367.0
TLS2_k127_5441770_4 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively K01243 - 3.2.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 295.0
TLS2_k127_5441770_5 Type I restriction enzyme R protein N terminus (HSDR_N) K07504 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003274 261.0
TLS2_k127_5441770_6 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000151 249.0
TLS2_k127_5441770_7 DNA restriction-modification system - - - 0.00000000000000000000000000000000000000000000000000000000000000009304 230.0
TLS2_k127_5441770_8 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000004859 186.0
TLS2_k127_5441770_9 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000001543 188.0
TLS2_k127_544823_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 2.366e-229 717.0
TLS2_k127_544823_1 TatD related DNase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004703 541.0
TLS2_k127_544823_2 membrane protein TerC - - - 0.00000000000000000000000000000000000000000000000000000000000001234 221.0
TLS2_k127_544823_3 methyltransferase K21459 - 2.1.1.301 0.0000000000000000000000000000000006016 134.0
TLS2_k127_5452657_0 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005373 595.0
TLS2_k127_5452657_1 cell volume homeostasis K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 337.0
TLS2_k127_5452657_2 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000681 201.0
TLS2_k127_5452657_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000002925 142.0
TLS2_k127_5544373_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.129e-295 919.0
TLS2_k127_5544373_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 2.922e-251 792.0
TLS2_k127_5544373_2 BrnA antitoxin of type II toxin-antitoxin system - - - 0.0003809 48.0
TLS2_k127_5565108_0 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 348.0
TLS2_k127_5565108_1 LysM domain - - - 0.000000002875 59.0
TLS2_k127_5565500_0 Binding-protein-dependent transport system inner membrane component K10229 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006687 444.0
TLS2_k127_5565500_1 ABC transporter K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 418.0
TLS2_k127_5565500_2 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 396.0
TLS2_k127_5565500_3 NAD(P)H-binding K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007185 311.0
TLS2_k127_5565500_4 2-keto-3-deoxy-L-rhamnonate aldolase activity K02510,K12660 - 4.1.2.52,4.1.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007498 308.0
TLS2_k127_5565500_5 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000001047 234.0
TLS2_k127_5565500_6 Molecular chaperone. Has ATPase activity K04079 - - 0.0000000000000000000000000000002497 124.0
TLS2_k127_5565500_7 - - - - 0.00000000000000006996 94.0
TLS2_k127_5580464_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 6.76e-234 743.0
TLS2_k127_5580464_1 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 636.0
TLS2_k127_5580464_10 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000001938 213.0
TLS2_k127_5580464_11 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000005113 209.0
TLS2_k127_5580464_12 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000001095 205.0
TLS2_k127_5580464_13 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000288 137.0
TLS2_k127_5580464_14 transcriptional - - - 0.0000000000000000000000000000000349 131.0
TLS2_k127_5580464_15 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000008837 128.0
TLS2_k127_5580464_16 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins - - - 0.0000000000000000000000002037 124.0
TLS2_k127_5580464_17 Protein of unknown function (DUF721) - - - 0.00000000000000000000003491 107.0
TLS2_k127_5580464_18 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000001394 96.0
TLS2_k127_5580464_19 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.000000000000002285 83.0
TLS2_k127_5580464_2 glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 500.0
TLS2_k127_5580464_20 Protein of unknown function (DUF1150) - - - 0.00000002113 62.0
TLS2_k127_5580464_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07638 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 477.0
TLS2_k127_5580464_4 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 455.0
TLS2_k127_5580464_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 433.0
TLS2_k127_5580464_6 endonuclease III K03575 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 374.0
TLS2_k127_5580464_7 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 300.0
TLS2_k127_5580464_8 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001264 255.0
TLS2_k127_5580464_9 protein containing LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000091 238.0
TLS2_k127_5608073_0 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 290.0
TLS2_k127_5608073_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000001432 195.0
TLS2_k127_56110_0 Metallo-beta-lactamase superfamily K12574 - - 3.631e-203 648.0
TLS2_k127_56110_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 550.0
TLS2_k127_56110_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 496.0
TLS2_k127_56110_3 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 370.0
TLS2_k127_56110_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 304.0
TLS2_k127_56110_5 Glyoxalase-like domain K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000002197 227.0
TLS2_k127_56110_6 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000000000000000492 222.0
TLS2_k127_56110_7 Protein of unknown function (DUF1467) - - - 0.000000001048 70.0
TLS2_k127_5627394_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.973e-300 930.0
TLS2_k127_5627394_1 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 2.313e-222 694.0
TLS2_k127_5627394_10 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000002785 138.0
TLS2_k127_5627394_11 Protein of unknwon function (DUF3008) - - - 0.000000000000000001038 88.0
TLS2_k127_5627394_12 - - - - 0.0000000002654 71.0
TLS2_k127_5627394_13 - - - - 0.0000000006242 67.0
TLS2_k127_5627394_14 - - - - 0.000003665 57.0
TLS2_k127_5627394_2 Serine aminopeptidase, S33 K01253,K08253 - 2.7.10.2,3.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005724 559.0
TLS2_k127_5627394_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000659 518.0
TLS2_k127_5627394_4 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 510.0
TLS2_k127_5627394_5 COG0616 Periplasmic serine proteases (ClpP class) K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009283 455.0
TLS2_k127_5627394_6 GDP-mannose 4,6 dehydratase K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 313.0
TLS2_k127_5627394_7 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000005044 246.0
TLS2_k127_5627394_8 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000007143 175.0
TLS2_k127_5627394_9 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.0000000000000000000000000000000000000004806 163.0
TLS2_k127_5635968_0 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 332.0
TLS2_k127_5635968_1 Domain of unknown function (DUF4105) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 344.0
TLS2_k127_5635968_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000003677 97.0
TLS2_k127_5635968_3 Membrane - - - 0.000000000000008213 84.0
TLS2_k127_5635968_4 Protein of unknown function (DUF3141) - - - 0.000000000000009964 81.0
TLS2_k127_5635968_6 KR domain K00019 - 1.1.1.30 0.00002133 50.0
TLS2_k127_5641562_0 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 526.0
TLS2_k127_5641562_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 372.0
TLS2_k127_5641562_2 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000002346 192.0
TLS2_k127_564247_0 Las17-binding protein actin regulator - - - 0.00000000000000000000000001845 115.0
TLS2_k127_5642592_0 Site-specific recombinase, DNA invertase Pin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003597 585.0
TLS2_k127_5650742_0 Probable molybdopterin binding domain K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 607.0
TLS2_k127_5650742_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 447.0
TLS2_k127_5650742_2 XdhC Rossmann domain K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001178 250.0
TLS2_k127_5650742_3 protein involved in outer membrane biogenesis K07290 - - 0.00000000000000000000000000000000000000000000000001714 208.0
TLS2_k127_5650742_4 protein involved in outer membrane biogenesis K07290 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - 0.000000000000000000000000000000000000000000002429 191.0
TLS2_k127_5653907_0 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 328.0
TLS2_k127_5653907_1 FAD dependent oxidoreductase K13796 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001607 263.0
TLS2_k127_5653907_2 polyketide synthase - - - 0.0000003744 58.0
TLS2_k127_5654255_0 GMC oxidoreductase - - - 4.775e-279 863.0
TLS2_k127_5654255_1 Glucose / Sorbosone dehydrogenase K00117,K21430 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 347.0
TLS2_k127_5654255_2 Squalene/phytoene synthase K21678,K21679 - 2.5.1.103,4.2.3.156 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009651 274.0
TLS2_k127_5654255_3 Phytoene synthase K21678 - 2.5.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000004911 264.0
TLS2_k127_5654255_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007136 256.0
TLS2_k127_5654255_5 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000004736 239.0
TLS2_k127_5654255_6 COG1073 hydrolases of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000000000004845 195.0
TLS2_k127_5654255_7 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000001844 169.0
TLS2_k127_5654255_8 (twin-arginine translocation) pathway signal - - - 0.00000000000000000000000000000000000001814 158.0
TLS2_k127_5654255_9 Protein of unknown function (DUF1178) - - - 0.000000000000000000000000000000000001405 143.0
TLS2_k127_5661827_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 445.0
TLS2_k127_5661827_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 422.0
TLS2_k127_5661827_2 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000003206 151.0
TLS2_k127_5661827_3 MerR HTH family regulatory protein - - - 0.000000000000000000000000000000000000004891 156.0
TLS2_k127_5661827_4 Ubiquinol-cytochrome C chaperone K17662 - - 0.00000000000000000000000000000003581 134.0
TLS2_k127_5661827_5 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000007888 96.0
TLS2_k127_5661827_6 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000002971 103.0
TLS2_k127_5661827_7 SmpA / OmlA family - - - 0.0000004238 58.0
TLS2_k127_5673918_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 7.097e-207 650.0
TLS2_k127_5673918_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 595.0
TLS2_k127_5673918_10 Uncharacterized conserved protein (DUF2267) - - - 0.0000000000000000000000000001433 120.0
TLS2_k127_5673918_11 Zinc-finger domain - - - 0.0000000000001695 73.0
TLS2_k127_5673918_12 Gluconolactonase K01053,K14274 - 3.1.1.17 0.0009201 45.0
TLS2_k127_5673918_2 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00520,K21739 - 1.16.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000786 581.0
TLS2_k127_5673918_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 430.0
TLS2_k127_5673918_4 Aldo/keto reductase family K00064 - 1.1.1.122 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006631 420.0
TLS2_k127_5673918_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000008956 241.0
TLS2_k127_5673918_6 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000000181 229.0
TLS2_k127_5673918_7 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 GO:0003674,GO:0003824,GO:0004341,GO:0016787,GO:0016788,GO:0052689 3.1.1.17 0.000000000000000000000000000000000000000000000000000000006718 205.0
TLS2_k127_5673918_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000008196 179.0
TLS2_k127_5673918_9 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000007616 141.0
TLS2_k127_5682553_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 535.0
TLS2_k127_5682553_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001214 281.0
TLS2_k127_5682553_2 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002264 261.0
TLS2_k127_5682553_3 Domain of unknown function DUF29 - - - 0.000000000000000000000000000006309 123.0
TLS2_k127_5683989_0 PQQ-like domain - - - 1.049e-255 805.0
TLS2_k127_5683989_1 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 607.0
TLS2_k127_5683989_2 L,D-transpeptidase catalytic domain K16291 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 334.0
TLS2_k127_5683989_3 COG0687 Spermidine putrescine-binding periplasmic protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008237 289.0
TLS2_k127_5683989_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005661 242.0
TLS2_k127_5683989_5 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000002084 235.0
TLS2_k127_5683989_6 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000000005363 185.0
TLS2_k127_5683989_7 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000002959 175.0
TLS2_k127_5683989_8 Domain of unknown function DUF29 - - - 0.00000000000000000000000000000000002325 140.0
TLS2_k127_5684857_0 Peptidase dimerisation domain K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 576.0
TLS2_k127_5684857_1 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 295.0
TLS2_k127_5684857_2 - - - - 0.0000000000000000000000000000000000000000000000000001241 191.0
TLS2_k127_5686338_0 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 456.0
TLS2_k127_5686338_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000002479 155.0
TLS2_k127_5686338_2 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016787,GO:0019538,GO:0023052,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.102 0.000002267 58.0
TLS2_k127_5698421_0 Esterase PHB depolymerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005295 468.0
TLS2_k127_5698421_1 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 382.0
TLS2_k127_5698421_2 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 326.0
TLS2_k127_5698421_3 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000334 259.0
TLS2_k127_5698421_4 Glutathione-dependent formaldehyde-activating K03396 - 4.4.1.22 0.000000000000000000000000000000000000000000000000000000000000003125 222.0
TLS2_k127_5698421_5 copG family - - - 0.000000000000000000000000000000000000000000000000000000000000005503 219.0
TLS2_k127_5698421_6 MgtE intracellular N domain - - - 0.000000000000000000000000000000000000000000000000000003661 196.0
TLS2_k127_5698421_7 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000001016 165.0
TLS2_k127_5698421_8 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000000001389 160.0
TLS2_k127_5698421_9 CrcB-like protein, Camphor Resistance (CrcB) - - - 0.000000000000000000000000000001221 128.0
TLS2_k127_5705362_0 Tripartite tricarboxylate transporter TctA family - - - 4.033e-273 854.0
TLS2_k127_5705362_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 488.0
TLS2_k127_5705362_2 PrpF protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 470.0
TLS2_k127_5705362_3 Succinyl-CoA ligase like flavodoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 398.0
TLS2_k127_5708468_0 ABC-type spermidine putrescine transport system, permease component I K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 550.0
TLS2_k127_5708468_1 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 459.0
TLS2_k127_5708468_2 Aldose 1-epimerase K01785 - 5.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000001906 255.0
TLS2_k127_5708468_3 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000004888 126.0
TLS2_k127_5708468_4 Belongs to the universal stress protein A family - - - 0.0000000000000000000000004558 110.0
TLS2_k127_5708468_5 - - - - 0.00001736 53.0
TLS2_k127_5717373_0 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 303.0
TLS2_k127_5717373_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000004757 171.0
TLS2_k127_5717373_2 Protein of unknown function (DUF3309) - - - 0.00000000000000000003248 90.0
TLS2_k127_5717373_3 DNA-templated transcription, initiation K01426,K22278 - 3.5.1.104,3.5.1.4 0.0000000000000002962 82.0
TLS2_k127_5720455_0 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006103 567.0
TLS2_k127_5720455_1 dipeptide transport K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 501.0
TLS2_k127_5720455_10 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 334.0
TLS2_k127_5720455_11 Catalase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000149 296.0
TLS2_k127_5720455_12 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway K03707 - 3.5.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000001195 261.0
TLS2_k127_5720455_13 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000001443 211.0
TLS2_k127_5720455_14 Ribbon-helix-helix protein, copG family - - - 0.00000000000000001672 83.0
TLS2_k127_5720455_15 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000003951 64.0
TLS2_k127_5720455_2 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 483.0
TLS2_k127_5720455_3 dipeptide transport K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 475.0
TLS2_k127_5720455_4 dipeptide transport K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000789 473.0
TLS2_k127_5720455_5 dipeptide transport K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 458.0
TLS2_k127_5720455_6 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 416.0
TLS2_k127_5720455_7 transport systems K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 406.0
TLS2_k127_5720455_8 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 385.0
TLS2_k127_5720455_9 Belongs to the ABC transporter superfamily K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 353.0
TLS2_k127_5735391_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 0.0 1043.0
TLS2_k127_5735391_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 3.13e-321 1003.0
TLS2_k127_5735391_10 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001476 285.0
TLS2_k127_5735391_11 SCP-2 sterol transfer family - - - 0.0000000000000001168 94.0
TLS2_k127_5735391_12 Cytochrome C556 - - - 0.00000000000007867 78.0
TLS2_k127_5735391_13 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000058 74.0
TLS2_k127_5735391_2 Hydantoinase/oxoprolinase - - - 4.23e-304 946.0
TLS2_k127_5735391_3 Hydantoinase B/oxoprolinase - - - 6.715e-299 930.0
TLS2_k127_5735391_4 COG1960 Acyl-CoA dehydrogenases K00248 - 1.3.8.1 3.522e-262 822.0
TLS2_k127_5735391_5 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 1.295e-210 671.0
TLS2_k127_5735391_6 Chain length determinant protein K16554 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 512.0
TLS2_k127_5735391_7 COG0534 Na -driven multidrug efflux pump K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 413.0
TLS2_k127_5735391_8 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007533 362.0
TLS2_k127_5735391_9 ubiquinone menaquinone biosynthesis methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005457 361.0
TLS2_k127_5741641_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 8.853e-296 914.0
TLS2_k127_5741641_1 Histidine K01745 - 4.3.1.3 0.0000000000000000818 81.0
TLS2_k127_5746011_0 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 3.552e-294 924.0
TLS2_k127_5746011_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 4.025e-273 856.0
TLS2_k127_5746011_10 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 420.0
TLS2_k127_5746011_11 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004088 388.0
TLS2_k127_5746011_12 Zn-dependent protease, contains TPR repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 382.0
TLS2_k127_5746011_13 TIGRFAM Molybdate ABC transporter K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 353.0
TLS2_k127_5746011_14 signal transduction histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 334.0
TLS2_k127_5746011_15 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 308.0
TLS2_k127_5746011_16 Amino acid synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001058 285.0
TLS2_k127_5746011_17 COG0725 ABC-type molybdate transport system, periplasmic component K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002971 274.0
TLS2_k127_5746011_18 Protein of unknown function (DUF1207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001864 261.0
TLS2_k127_5746011_19 HpcH/HpaI aldolase/citrate lyase family - - - 0.0000000000000000000000000000000000000000000000000000000000000004319 228.0
TLS2_k127_5746011_2 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 600.0
TLS2_k127_5746011_20 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000000000000007072 217.0
TLS2_k127_5746011_21 Peptidoglycan-binding domain 1 protein K03194,K07273,K08307,K08309,K12089 - - 0.0000000000000000000000000000000000000000000004685 188.0
TLS2_k127_5746011_22 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000000000000000001004 147.0
TLS2_k127_5746011_23 Domain of unknown function DUF29 - - - 0.00000000000000000000000000001946 123.0
TLS2_k127_5746011_25 DSBA-like thioredoxin domain - - - 0.0000168 51.0
TLS2_k127_5746011_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 514.0
TLS2_k127_5746011_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 505.0
TLS2_k127_5746011_5 TIGRFAM sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 482.0
TLS2_k127_5746011_6 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 454.0
TLS2_k127_5746011_7 sulfate transport system, permease K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 420.0
TLS2_k127_5746011_8 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 419.0
TLS2_k127_5746011_9 Sulfate ABC transporter inner membrane subunit CysT K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 400.0
TLS2_k127_5749349_0 His Kinase A (phosphoacceptor) domain - - - 1.782e-268 853.0
TLS2_k127_5749349_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 488.0
TLS2_k127_5749349_10 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000102 53.0
TLS2_k127_5749349_2 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 425.0
TLS2_k127_5749349_3 Extracellular solute-binding protein K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 314.0
TLS2_k127_5749349_4 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004017 273.0
TLS2_k127_5749349_5 cheY-homologous receiver domain K11443 - - 0.00000000000000000000000000000000000000000000000001605 188.0
TLS2_k127_5749349_6 DoxX K15977 - - 0.00000000000000000000001592 101.0
TLS2_k127_5749349_7 Nucleotidyltransferase domain K07075 - - 0.000000000000009259 81.0
TLS2_k127_5749349_8 Protein of unknown function DUF86 - - - 0.00000000000001318 75.0
TLS2_k127_5749349_9 PFAM MscS Mechanosensitive ion channel K22044 - - 0.00000001252 68.0
TLS2_k127_5757721_0 His Kinase A (phosphoacceptor) domain - - - 9.001e-261 845.0
TLS2_k127_5757721_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 549.0
TLS2_k127_5757721_10 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000003111 205.0
TLS2_k127_5757721_11 protein involved in outer membrane biogenesis K07290 - - 0.0000000000000000000000000000000000000000000000000000000003436 232.0
TLS2_k127_5757721_12 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.00000000000000000000000000000000001557 145.0
TLS2_k127_5757721_13 FecR protein - - - 0.0000000000000000000000000108 128.0
TLS2_k127_5757721_14 - - - - 0.000000000000000000003918 105.0
TLS2_k127_5757721_15 - - - - 0.0000000000000002497 90.0
TLS2_k127_5757721_16 von willebrand factor, type A K12549 - - 0.0000000000005422 83.0
TLS2_k127_5757721_17 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000006419 60.0
TLS2_k127_5757721_18 transporter - - - 0.000006591 58.0
TLS2_k127_5757721_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 516.0
TLS2_k127_5757721_3 Glucose Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 464.0
TLS2_k127_5757721_4 diaminopimelate decarboxylase activity K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007001 459.0
TLS2_k127_5757721_5 Putative serine dehydratase domain K01753 - 4.3.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 456.0
TLS2_k127_5757721_6 ATP-grasp domain K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 367.0
TLS2_k127_5757721_7 Protein of unknown function (DUF3365) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003058 273.0
TLS2_k127_5757721_8 sugar transferase K03606 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001848 267.0
TLS2_k127_5757721_9 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000009633 245.0
TLS2_k127_5758173_0 Bacterial extracellular solute-binding proteins, family 5 Middle K12368 - - 1.409e-254 795.0
TLS2_k127_5758173_1 Creatinase/Prolidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003196 478.0
TLS2_k127_5758173_10 Aldolase/RraA K02553 - - 0.0000000000000000000000000000000000000000007373 170.0
TLS2_k127_5758173_11 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000007946 136.0
TLS2_k127_5758173_12 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000001592 88.0
TLS2_k127_5758173_14 - - - - 0.0006143 51.0
TLS2_k127_5758173_2 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000812 441.0
TLS2_k127_5758173_3 Alginate export - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000688 333.0
TLS2_k127_5758173_4 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001418 277.0
TLS2_k127_5758173_5 phosphatidylcholine synthase activity K01004 - 2.7.8.24 0.0000000000000000000000000000000000000000000000000000000000000000000000201 249.0
TLS2_k127_5758173_6 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000001097 219.0
TLS2_k127_5758173_7 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.0000000000000000000000000000000000000000000000000000008511 200.0
TLS2_k127_5758173_8 TIGRFAM outer membrane autotransporter barrel - - - 0.000000000000000000000000000000000000000000000006722 191.0
TLS2_k127_5758173_9 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000001991 171.0
TLS2_k127_5760008_0 COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 1.017e-229 733.0
TLS2_k127_5760008_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 3.462e-208 660.0
TLS2_k127_5760008_2 Chromate transporter K07240 - - 3.02e-199 635.0
TLS2_k127_5760008_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 454.0
TLS2_k127_5760008_4 COG0607 Rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 434.0
TLS2_k127_5760008_5 PAS domain K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 420.0
TLS2_k127_5760008_6 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 0.0000003431 52.0
TLS2_k127_5760218_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1070.0
TLS2_k127_5760218_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 5.116e-254 791.0
TLS2_k127_5760218_10 Histidine kinase - - - 0.0000000000000000000000000000000000000007529 163.0
TLS2_k127_5760218_11 - - - - 0.00000000000002222 85.0
TLS2_k127_5760218_12 AAA domain (dynein-related subfamily) - - - 0.0000000000004479 70.0
TLS2_k127_5760218_13 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000002273 78.0
TLS2_k127_5760218_2 glutamate--cysteine ligase K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 546.0
TLS2_k127_5760218_3 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009376 451.0
TLS2_k127_5760218_4 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 377.0
TLS2_k127_5760218_5 Nuclease (SNase-like) K01174 - 3.1.31.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 344.0
TLS2_k127_5760218_6 Short-chain dehydrogenase reductase SDR K00059,K18337 - 1.1.1.100,1.1.1.173,1.1.1.377,1.1.1.378 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001418 286.0
TLS2_k127_5760218_7 Transcriptional regulator K07013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001505 255.0
TLS2_k127_5760218_8 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000002122 215.0
TLS2_k127_5760218_9 pyrroline-5-carboxylate reductase activity K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000001698 171.0
TLS2_k127_5761976_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000396 415.0
TLS2_k127_5761976_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00066 - 1.1.1.132 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 361.0
TLS2_k127_5761976_2 Glycosyl transferases group 1 - - - 0.000000000000000000000000000006919 121.0
TLS2_k127_5765586_0 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000493 282.0
TLS2_k127_5765586_1 ABC transporter K02049 - - 0.000000000000000000000000000000000000000000000000000000000000001107 227.0
TLS2_k127_5765586_2 SCO1/SenC K07152 - - 0.000000000000000000000000000000000000000000000000000000000000004014 220.0
TLS2_k127_5765586_3 Glyoxalase-like domain K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000004519 185.0
TLS2_k127_5768990_0 Glycosyl Transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001563 528.0
TLS2_k127_5768990_1 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 484.0
TLS2_k127_5768990_2 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 344.0
TLS2_k127_5768990_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000008723 66.0
TLS2_k127_5768990_4 - - - - 0.0000006336 61.0
TLS2_k127_578476_0 peptidase S45, penicillin amidase K01434 - 3.5.1.11 8.954e-246 782.0
TLS2_k127_578476_1 Putative diguanylate phosphodiesterase - - - 1.965e-210 676.0
TLS2_k127_578476_10 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000001775 233.0
TLS2_k127_578476_11 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000292 217.0
TLS2_k127_578476_12 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain K15012 - - 0.00000000000000000000000000000000000000000000000003712 188.0
TLS2_k127_578476_13 Belongs to the Nudix hydrolase family - - - 0.000000000000000000000000000000000000000000007944 167.0
TLS2_k127_578476_14 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000001731 161.0
TLS2_k127_578476_15 - - - - 0.0000000000000000000000000000000000005094 141.0
TLS2_k127_578476_16 Cytochrome c K08738 - - 0.0000000000000000000000000000001871 131.0
TLS2_k127_578476_17 Belongs to the ompA family - - - 0.0000000000000000000003335 111.0
TLS2_k127_578476_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 569.0
TLS2_k127_578476_3 Malonyl-CoA decarboxylase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 450.0
TLS2_k127_578476_4 D-amino acid K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 419.0
TLS2_k127_578476_5 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008334 323.0
TLS2_k127_578476_6 FIST_C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 321.0
TLS2_k127_578476_7 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004236 278.0
TLS2_k127_578476_8 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000061 268.0
TLS2_k127_578476_9 Enoyl-CoA hydratase/isomerase K13816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008364 267.0
TLS2_k127_5811185_0 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005465 501.0
TLS2_k127_5811185_1 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003134 493.0
TLS2_k127_5811185_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 365.0
TLS2_k127_5811185_3 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 329.0
TLS2_k127_5811185_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000006865 244.0
TLS2_k127_5811185_5 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000000009228 229.0
TLS2_k127_5811185_6 - - - - 0.000000000000000000000000000000001545 139.0
TLS2_k127_5811185_7 - - - - 0.000000109 61.0
TLS2_k127_5818637_0 2'-deoxycytidine 5'-triphosphate deaminase (DCD) K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 459.0
TLS2_k127_5818637_1 Belongs to the binding-protein-dependent transport system permease family K10440 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 423.0
TLS2_k127_5818637_2 ABC-type sugar transport system, periplasmic component K10439,K10549 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 409.0
TLS2_k127_5818637_3 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000606 382.0
TLS2_k127_5818637_4 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005682 299.0
TLS2_k127_5818637_5 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005966 301.0
TLS2_k127_5818637_6 MazG nucleotide pyrophosphohydrolase domain - - - 0.000000000000000000000000000000002584 132.0
TLS2_k127_5826993_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.531e-282 900.0
TLS2_k127_5826993_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 375.0
TLS2_k127_5826993_2 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 377.0
TLS2_k127_5826993_3 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 336.0
TLS2_k127_5826993_4 nucleic-acid-binding protein implicated in transcription termination K07742 - - 0.000000000000000000000000000000000000000000000001702 182.0
TLS2_k127_5826993_5 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000004545 134.0
TLS2_k127_5826993_6 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000003171 119.0
TLS2_k127_5831579_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0 1234.0
TLS2_k127_5831579_1 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 3.947e-223 705.0
TLS2_k127_5831579_10 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000006648 171.0
TLS2_k127_5831579_11 RDD family - - - 0.0000000000000000000000000000009831 127.0
TLS2_k127_5831579_12 Phasin protein - - - 0.000000000000000000002579 102.0
TLS2_k127_5831579_2 ornithine cyclodeaminase K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 490.0
TLS2_k127_5831579_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 482.0
TLS2_k127_5831579_4 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 414.0
TLS2_k127_5831579_5 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 354.0
TLS2_k127_5831579_6 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 321.0
TLS2_k127_5831579_7 Phosphorylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009579 242.0
TLS2_k127_5831579_8 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000001663 243.0
TLS2_k127_5839532_0 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009327 417.0
TLS2_k127_5839532_1 COG1129 ABC-type sugar transport system, ATPase component K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009437 414.0
TLS2_k127_5839532_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000001542 220.0
TLS2_k127_5874023_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1062.0
TLS2_k127_5900024_0 Oligopeptide/dipeptide transporter, C-terminal region - - - 3.366e-311 981.0
TLS2_k127_5900024_1 Carbohydrate phosphorylase K00688 - 2.4.1.1 1.069e-235 741.0
TLS2_k127_5900024_10 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001113 279.0
TLS2_k127_5900024_11 COG0410 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005817 259.0
TLS2_k127_5900024_12 OHCU decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000008593 204.0
TLS2_k127_5900024_13 Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily K07127 - 3.5.2.17 0.000000000000000000000000000000000000000000001165 168.0
TLS2_k127_5900024_14 - - - - 0.00000000000000000000000000000000000005493 148.0
TLS2_k127_5900024_15 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000001048 130.0
TLS2_k127_5900024_16 - - - - 0.000000000000000000000000002071 121.0
TLS2_k127_5900024_17 xanthine dehydrogenase, molybdopterin binding subunit K13482 - 1.17.1.4 0.000000000000000000005705 95.0
TLS2_k127_5900024_2 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 577.0
TLS2_k127_5900024_3 CO dehydrogenase flavoprotein C-terminal domain K13481 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009109 549.0
TLS2_k127_5900024_4 secondary active sulfate transmembrane transporter activity K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 512.0
TLS2_k127_5900024_5 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007587 489.0
TLS2_k127_5900024_6 N-terminal TM domain of oligopeptide transport permease C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 423.0
TLS2_k127_5900024_7 Receptor family ligand binding region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008869 413.0
TLS2_k127_5900024_8 COG4177 ABC-type branched-chain amino acid transport system, permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 320.0
TLS2_k127_5900024_9 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 311.0
TLS2_k127_5905921_0 TRAP transporter, 4TM 12TM fusion protein - - - 0.0 1106.0
TLS2_k127_5905921_1 Universal stress protein family - - - 0.000000000000000000000000000000000000000000003599 167.0
TLS2_k127_5905921_2 NADH ubiquinone oxidoreductase subunit NDUFA12 K00356 - 1.6.99.3 0.000000000000000000000000006893 113.0
TLS2_k127_5911994_0 SMART PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 377.0
TLS2_k127_5911994_1 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000003993 200.0
TLS2_k127_5911994_2 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000001616 184.0
TLS2_k127_5914888_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 486.0
TLS2_k127_5914888_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000456 275.0
TLS2_k127_5935404_0 ABC transporter transmembrane region K06021,K06147,K11004,K13409,K20344 - 3.6.3.27 1.627e-222 711.0
TLS2_k127_5935404_1 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 537.0
TLS2_k127_5935404_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 487.0
TLS2_k127_5935404_3 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 462.0
TLS2_k127_5935404_4 type I secretion membrane fusion protein, HlyD family K02022,K11003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002315 261.0
TLS2_k127_5935404_5 - - - - 0.000000000003382 69.0
TLS2_k127_5935404_6 Antibiotic biosynthesis monooxygenase - - - 0.00000003428 66.0
TLS2_k127_5940024_0 Pfam:HipA_N K07154 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 293.0
TLS2_k127_5940024_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000005991 224.0
TLS2_k127_5940024_2 NnrU protein - - - 0.000000000000000000000000000000000000000000000000000000000004724 222.0
TLS2_k127_5940024_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000006944 83.0
TLS2_k127_5943425_0 Glycosyl Hydrolase Family 88 K18581 - 3.2.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 529.0
TLS2_k127_5943425_1 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 475.0
TLS2_k127_5943425_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 370.0
TLS2_k127_5943425_3 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000000001219 216.0
TLS2_k127_5943425_4 Ureidoglycolate lyase - - - 0.000000000000000000000000000000000000000000000000000000004219 206.0
TLS2_k127_5944241_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 5.11e-199 632.0
TLS2_k127_5944241_1 COG0744 Membrane carboxypeptidase (penicillin-binding protein) K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 522.0
TLS2_k127_5944241_2 hydrolase activity, acting on ester bonds K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000002764 246.0
TLS2_k127_5944241_3 Protein of unknown function (DUF3553) - - - 0.000000000000000001058 87.0
TLS2_k127_5944241_4 - - - - 0.00000003237 58.0
TLS2_k127_5945009_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008936 258.0
TLS2_k127_5945009_1 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.0000008322 52.0
TLS2_k127_5945009_2 Bacterial-like globin K06886 - - 0.0001269 48.0
TLS2_k127_595792_0 Branched-chain amino acid transport system / permease component K01997,K01998 - - 6.325e-233 735.0
TLS2_k127_595792_1 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 351.0
TLS2_k127_595792_2 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000001335 168.0
TLS2_k127_5975184_0 DEAD/H associated K03724 - - 7.97e-302 943.0
TLS2_k127_5975184_1 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005713 570.0
TLS2_k127_5975184_2 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 545.0
TLS2_k127_5975184_3 Rv0623-like transcription factor K19687 - - 0.0000000000318 67.0
TLS2_k127_5983913_0 Nuclease-related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007203 448.0
TLS2_k127_5991054_0 PFAM AMP-dependent synthetase and ligase K00666 - - 2.867e-278 864.0
TLS2_k127_5991054_1 COG1960 Acyl-CoA dehydrogenases K00253 - 1.3.8.4 1.072e-207 650.0
TLS2_k127_5991054_2 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 432.0
TLS2_k127_5991054_3 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 414.0
TLS2_k127_5991054_4 PFAM Phosphate acetyl butaryl transferase K00029 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000005218 214.0
TLS2_k127_5991054_5 beta-lactamase activity K07126 - - 0.00000000001959 76.0
TLS2_k127_5999682_0 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004214 367.0
TLS2_k127_5999682_1 PFAM Integrase catalytic region K07497 - - 0.0000000000000000000000000000000000000000000005587 171.0
TLS2_k127_5999682_2 Stringent starvation protein B K09985 - - 0.0000000000000000000000000000000000000000006926 166.0
TLS2_k127_5999682_3 Integrase core domain - - - 0.00000000003209 68.0
TLS2_k127_6004816_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 613.0
TLS2_k127_6004816_1 Potassium transporter peripheral membrane component K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 589.0
TLS2_k127_6009513_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007564 600.0
TLS2_k127_6009513_1 Manganese containing catalase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 438.0
TLS2_k127_6009513_10 - - - - 0.00006689 49.0
TLS2_k127_6009513_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 406.0
TLS2_k127_6009513_3 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004644 287.0
TLS2_k127_6009513_4 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001267 255.0
TLS2_k127_6009513_5 Aminoacyl-tRNA editing domain K19055 - - 0.00000000000000000000000000000000000000000000001158 196.0
TLS2_k127_6009513_6 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000001092 162.0
TLS2_k127_6009513_7 Ferric uptake regulator family K03711,K09825 - - 0.0000000000000000000000000000000000000001989 154.0
TLS2_k127_6009513_8 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000001429 109.0
TLS2_k127_6009513_9 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000001051 72.0
TLS2_k127_6013223_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 514.0
TLS2_k127_6013223_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000007095 231.0
TLS2_k127_6013223_2 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000001487 148.0
TLS2_k127_60193_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1309.0
TLS2_k127_60193_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.4.2 0.0 1146.0
TLS2_k127_60193_10 MlaD protein K02067,K06192 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006264 252.0
TLS2_k127_60193_11 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K09565 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000008014 241.0
TLS2_k127_60193_12 CarD-like/TRCF domain K07736 - - 0.000000000000000000000000000000000000000000000000000000001998 205.0
TLS2_k127_60193_13 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.0000000000000000000000000000000000000000000000000000003458 198.0
TLS2_k127_60193_14 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000002039 173.0
TLS2_k127_60193_15 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000002608 174.0
TLS2_k127_60193_16 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02397 - - 0.0000000000000000000000000000000000000000002376 183.0
TLS2_k127_60193_17 ABC-type transport auxiliary lipoprotein component K18480 - - 0.0000000000000000000000000000000000000000007495 177.0
TLS2_k127_60193_18 Domain of unknown function DUF29 - - - 0.0000000000000000000000000000000000007295 145.0
TLS2_k127_60193_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 1.63e-208 667.0
TLS2_k127_60193_20 Rod binding protein - - - 0.000000000000001657 84.0
TLS2_k127_60193_21 Protein of unknown function (DUF3035) - - - 0.00000000000001104 84.0
TLS2_k127_60193_22 flagellar assembly - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000005588 72.0
TLS2_k127_60193_3 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009887 499.0
TLS2_k127_60193_4 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 484.0
TLS2_k127_60193_5 Peptidase M16 inactive domain K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 472.0
TLS2_k127_60193_6 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 441.0
TLS2_k127_60193_7 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 383.0
TLS2_k127_60193_8 ATPases associated with a variety of cellular activities K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 350.0
TLS2_k127_60193_9 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 291.0
TLS2_k127_6024556_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 539.0
TLS2_k127_6024556_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009371 520.0
TLS2_k127_6024556_2 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000004371 253.0
TLS2_k127_6037452_0 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 376.0
TLS2_k127_6037452_1 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000555 350.0
TLS2_k127_6037452_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 289.0
TLS2_k127_6037452_3 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000001662 234.0
TLS2_k127_6037452_4 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000012 213.0
TLS2_k127_6037452_5 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000000000000001634 213.0
TLS2_k127_6037452_6 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000006525 168.0
TLS2_k127_6037452_7 Putative restriction endonuclease - - - 0.000000000000000000000000000000000001287 145.0
TLS2_k127_6037452_8 SnoaL-like domain - - - 0.0000000000000000000000000006464 128.0
TLS2_k127_6038405_0 N-terminal TM domain of oligopeptide transport permease C K02034,K13891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 365.0
TLS2_k127_6038405_1 Belongs to the ABC transporter superfamily K02031,K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004045 251.0
TLS2_k127_6038405_2 MULE transposase domain K07493 - - 0.00000000000001522 76.0
TLS2_k127_6038405_3 PFAM Glycoside hydrolase 15-related - - - 0.0000000000001428 77.0
TLS2_k127_60473_0 ABC-type sugar transport system, periplasmic component K02027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 437.0
TLS2_k127_60473_1 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 415.0
TLS2_k127_60473_2 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 359.0
TLS2_k127_60473_3 Na+/Pi-cotransporter K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002375 269.0
TLS2_k127_60473_4 NADH dehydrogenase K03885 - 1.6.99.3 0.00000000000000000003281 92.0
TLS2_k127_60473_5 Virulence-associated protein K18829 - - 0.0000000000002679 71.0
TLS2_k127_6053182_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 2.566e-303 942.0
TLS2_k127_6053182_1 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 2.177e-198 644.0
TLS2_k127_6053182_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006378 271.0
TLS2_k127_6053182_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000000000004768 241.0
TLS2_k127_6053182_4 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000007741 160.0
TLS2_k127_6053182_5 PFAM cytochrome c class I K08738 - - 0.000000000000000000000000000000007194 131.0
TLS2_k127_6053182_6 Transmembrane family 220, helix - - - 0.00000001402 61.0
TLS2_k127_6061732_0 Aldehyde oxidase and xanthine dehydrogenase a b hammerhead K13482 - 1.17.1.4 2.848e-265 826.0
TLS2_k127_6061732_1 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 619.0
TLS2_k127_6061732_10 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 317.0
TLS2_k127_6061732_11 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008107 314.0
TLS2_k127_6061732_12 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001126 290.0
TLS2_k127_6061732_13 Xanthine dehydrogenase accessory protein XdhC K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000008524 243.0
TLS2_k127_6061732_14 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000416 225.0
TLS2_k127_6061732_15 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000194 212.0
TLS2_k127_6061732_16 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000005038 205.0
TLS2_k127_6061732_17 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.00000000000000000000000000000000000000000000000004354 189.0
TLS2_k127_6061732_18 COQ9 K18587 - - 0.0000000000000000000000000000000000000000000000003288 194.0
TLS2_k127_6061732_19 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000331 167.0
TLS2_k127_6061732_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 593.0
TLS2_k127_6061732_20 Belongs to the peptidase S1B family - - - 0.0000000000000000000000000000000000009683 153.0
TLS2_k127_6061732_21 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000002043 109.0
TLS2_k127_6061732_3 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 504.0
TLS2_k127_6061732_4 ABC transporter substrate-binding protein PnrA-like K02058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 493.0
TLS2_k127_6061732_5 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008822 474.0
TLS2_k127_6061732_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 387.0
TLS2_k127_6061732_7 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 398.0
TLS2_k127_6061732_8 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 375.0
TLS2_k127_6061732_9 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 - 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 385.0
TLS2_k127_6062517_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 390.0
TLS2_k127_6062517_1 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000003897 229.0
TLS2_k127_6062517_2 TIGRFAM TRAP transporter, DctM subunit - - - 0.000000000000000000000000000000000004556 145.0
TLS2_k127_6062517_3 Short-chain dehydrogenase reductase sdr - - - 0.0000000009698 59.0
TLS2_k127_606886_0 Domain of unknown function (DUF3333) K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 505.0
TLS2_k127_606886_1 - - - - 0.000000753 58.0
TLS2_k127_6098910_0 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000749 626.0
TLS2_k127_6098910_1 Domain of unknown function (DUF4175) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 545.0
TLS2_k127_6098910_10 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.0000000000000000000000000000000000000000000001888 175.0
TLS2_k127_6098910_11 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000006949 182.0
TLS2_k127_6098910_12 KAP family P-loop domain - - - 0.0000000000000000000000000000001273 139.0
TLS2_k127_6098910_13 LrgA family K06518 - - 0.0000000000000000000000000000002447 126.0
TLS2_k127_6098910_14 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000001573 107.0
TLS2_k127_6098910_15 Antidote-toxin recognition MazE, bacterial antitoxin - - - 0.000000004458 64.0
TLS2_k127_6098910_2 TIGRFAM TRAP transporter, DctM subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 460.0
TLS2_k127_6098910_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 432.0
TLS2_k127_6098910_4 Succinylglutamate desuccinylase / Aspartoacylase family K15784 - 3.5.1.125 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 389.0
TLS2_k127_6098910_5 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 352.0
TLS2_k127_6098910_6 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 310.0
TLS2_k127_6098910_7 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 300.0
TLS2_k127_6098910_8 effector of murein hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 296.0
TLS2_k127_6098910_9 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily K15268 - - 0.000000000000000000000000000000000000000000000000000001165 202.0
TLS2_k127_6100690_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1463.0
TLS2_k127_6100690_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 1.796e-216 686.0
TLS2_k127_6100690_10 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000004521 223.0
TLS2_k127_6100690_11 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000000000000001832 241.0
TLS2_k127_6100690_12 Cupin - - - 0.0000000000000000000000000000000000000000000000000000005246 202.0
TLS2_k127_6100690_13 Domain of unknown function DUF29 - - - 0.000000000000000000000000000000000000007446 151.0
TLS2_k127_6100690_14 Lysylphosphatidylglycerol synthase TM region - - - 0.000000000000000000000000000006311 132.0
TLS2_k127_6100690_16 FR47-like protein - - - 0.0000000000000000000001357 114.0
TLS2_k127_6100690_17 - - - - 0.0000000000000000001907 97.0
TLS2_k127_6100690_18 Alpha amylase, catalytic domain - - - 0.0000000000000000006598 89.0
TLS2_k127_6100690_2 Aldehyde dehydrogenase family - - - 1.713e-203 642.0
TLS2_k127_6100690_20 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000001281 86.0
TLS2_k127_6100690_21 Belongs to the glycosyl hydrolase 13 family - - - 0.0000000000543 74.0
TLS2_k127_6100690_22 Recombinase zinc beta ribbon domain - - - 0.00004389 46.0
TLS2_k127_6100690_23 Integrase core domain K07497 - - 0.0004608 48.0
TLS2_k127_6100690_3 organic phosphonate transport K02044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 411.0
TLS2_k127_6100690_4 organic phosphonate transport K02044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 397.0
TLS2_k127_6100690_5 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006294 387.0
TLS2_k127_6100690_6 glycosyl transferase group 1 K03208 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 375.0
TLS2_k127_6100690_7 organic phosphonate transmembrane transporter activity K02042,K06162 - 3.6.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 365.0
TLS2_k127_6100690_8 COG3639 ABC-type phosphate phosphonate transport system, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 368.0
TLS2_k127_6100690_9 Belongs to the UPF0173 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 311.0
TLS2_k127_6113906_0 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 6.622e-205 645.0
TLS2_k127_6113906_1 FAD dependent oxidoreductase - - - 1.849e-201 643.0
TLS2_k127_6113906_10 Sugar (and other) transporter K07552 - - 0.00000000000000001339 89.0
TLS2_k127_6113906_11 D-alanyl-D-alanine carboxypeptidase K17733 - - 0.0000000009836 61.0
TLS2_k127_6113906_12 - - - - 0.0000000381 61.0
TLS2_k127_6113906_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 507.0
TLS2_k127_6113906_3 Shikimate dehydrogenase K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 421.0
TLS2_k127_6113906_4 FCD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 293.0
TLS2_k127_6113906_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005206 240.0
TLS2_k127_6113906_6 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000258 228.0
TLS2_k127_6113906_7 Dehydroquinase class II K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000001423 224.0
TLS2_k127_6113906_8 PFAM Coenzyme A transferase K01026 - 2.8.3.1 0.0000000000000000003791 90.0
TLS2_k127_6113906_9 - - - - 0.000000000000000001261 92.0
TLS2_k127_6116530_0 - - - - 0.000000000000000000000000000003286 124.0
TLS2_k127_6140382_0 TonB-dependent receptor, beta-barrel - - - 1.85e-259 833.0
TLS2_k127_6153491_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.0 2466.0
TLS2_k127_6153491_1 - - - - 0.00000000000000000000000001101 116.0
TLS2_k127_6153491_2 Histidine kinase - - - 0.00000000000000000000000002823 110.0
TLS2_k127_6153491_3 - - - - 0.0000000000000000205 84.0
TLS2_k127_6256574_0 CheB methylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003221 255.0
TLS2_k127_6256574_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.00000000000000000000002532 103.0
TLS2_k127_6260061_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009558 550.0
TLS2_k127_6260061_1 Oxidoreductase FAD-binding domain K02613 - - 0.00000000000000000000001743 102.0
TLS2_k127_6260061_2 Cell wall formation K00075 - 1.3.1.98 0.00000000000003887 72.0
TLS2_k127_631051_0 MaoC like domain K14449 GO:0003674,GO:0003824,GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0045733,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 469.0
TLS2_k127_631051_1 Phosphotriesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 454.0
TLS2_k127_631051_2 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 381.0
TLS2_k127_631051_3 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 319.0
TLS2_k127_631051_5 - - - - 0.000000000000000001431 91.0
TLS2_k127_632117_0 Outer membrane usher protein K07347 - - 2.814e-199 649.0
TLS2_k127_632117_1 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 409.0
TLS2_k127_632117_2 Peptidoglycan-binding domain 1 protein K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009207 362.0
TLS2_k127_632117_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000001242 242.0
TLS2_k127_632117_4 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000005067 216.0
TLS2_k127_632117_5 DNA polymerase III subunit delta K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000004217 166.0
TLS2_k127_632117_6 Spore Coat Protein U domain - - - 0.00000000000001881 82.0
TLS2_k127_632432_0 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006126 549.0
TLS2_k127_632432_1 Flavin containing amine oxidoreductase K06954 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 456.0
TLS2_k127_632432_2 synthase K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0008825,GO:0009987,GO:0016740,GO:0016741,GO:0030258,GO:0032259,GO:0044237,GO:0044238,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 389.0
TLS2_k127_632432_3 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 324.0
TLS2_k127_632432_4 Protein of unknown function (DUF1365) K09701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005209 263.0
TLS2_k127_632432_5 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003459 253.0
TLS2_k127_632432_6 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000000000000000000000000001397 207.0
TLS2_k127_632432_7 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000001082 173.0
TLS2_k127_632432_8 Beta-lactamase superfamily domain - - - 0.000000000000000000007613 93.0
TLS2_k127_637892_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 484.0
TLS2_k127_637892_1 ISXO2-like transposase domain - - - 0.000000000000003143 79.0
TLS2_k127_637892_2 ISXO2-like transposase domain - - - 0.000001239 52.0
TLS2_k127_6380625_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004921 593.0
TLS2_k127_6380625_1 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002944 269.0
TLS2_k127_6415391_0 Oligopeptidase F K08602 - - 7.667e-271 846.0
TLS2_k127_6415391_1 Binding-protein-dependent transport system inner membrane component K02011 - - 2.684e-207 661.0
TLS2_k127_6415391_2 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 1.604e-203 651.0
TLS2_k127_6415391_3 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007433 611.0
TLS2_k127_6415391_4 COG2998 ABC-type tungstate transport system, permease component K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 365.0
TLS2_k127_6415391_5 ABC-type tungstate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 294.0
TLS2_k127_6415391_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 295.0
TLS2_k127_6415391_7 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005068 292.0
TLS2_k127_6415391_8 - - - - 0.000000000000000002454 89.0
TLS2_k127_6415391_9 Metallo-beta-lactamase superfamily - - - 0.000000000000000005563 83.0
TLS2_k127_6445853_0 Peptidase inhibitor I9 K20754 - 3.4.21.111 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 331.0
TLS2_k127_6445853_1 Ferredoxin - - - 0.0000000000000000004679 101.0
TLS2_k127_6467654_0 Adenylate cyclase - - - 2.533e-256 807.0
TLS2_k127_6467654_1 Fe-S metabolism associated domain - - - 0.000000000000000000000000000000000003432 143.0
TLS2_k127_6467654_2 NAD dependent epimerase/dehydratase family - - - 0.0001065 48.0
TLS2_k127_64941_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 5.784e-225 707.0
TLS2_k127_64941_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 527.0
TLS2_k127_64941_2 Animal haem peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 426.0
TLS2_k127_64941_3 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 340.0
TLS2_k127_64941_4 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000001607 209.0
TLS2_k127_64941_5 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.000000000000000004433 92.0
TLS2_k127_64941_6 AcrB/AcrD/AcrF family K03296,K18902 - - 0.00000001081 57.0
TLS2_k127_653818_0 PFAM transposase IS116 IS110 IS902 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 432.0
TLS2_k127_653818_1 COG4584 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006018 365.0
TLS2_k127_653818_2 Integrase core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001045 226.0
TLS2_k127_653818_3 TIGRFAM DNA phosphorothioation-associated - - - 0.00000000000000000000000000000000000000000000000000005535 190.0
TLS2_k127_653818_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000001829 101.0
TLS2_k127_653818_5 COG4584 Transposase and inactivated derivatives - - - 0.0000000000000000001914 89.0
TLS2_k127_653818_6 PFAM Integrase catalytic - - - 0.0000000000000000756 82.0
TLS2_k127_653818_7 - - - - 0.0000000000008664 69.0
TLS2_k127_653818_8 - - - - 0.000000006051 59.0
TLS2_k127_6540514_0 PFAM DNA photolyase, FAD-binding K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 557.0
TLS2_k127_6540514_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 542.0
TLS2_k127_6540514_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 476.0
TLS2_k127_6540514_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 435.0
TLS2_k127_6540514_4 Crp-like helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007896 273.0
TLS2_k127_6540514_5 CheB methylesterase K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000002238 201.0
TLS2_k127_6540514_6 Protein of unknown function (DUF3833) - - - 0.00000000000000000000000000000000000000000000000000001989 193.0
TLS2_k127_6540514_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000005958 181.0
TLS2_k127_6540514_8 DNA repair protein MmcB-like - - - 0.0000000000000000000000000000000000003343 146.0
TLS2_k127_6543304_0 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 353.0
TLS2_k127_6543304_1 ATPases associated with a variety of cellular activities K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000001319 190.0
TLS2_k127_6543304_2 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000006653 108.0
TLS2_k127_6543304_3 Ribosomal L32p protein family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.00000000000000002492 87.0
TLS2_k127_6556417_0 Periplasmic binding protein domain K11959 - - 2.32e-201 648.0
TLS2_k127_6556417_1 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004655 425.0
TLS2_k127_6556417_2 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000001001 130.0
TLS2_k127_6573140_0 AIR synthase related protein, N-terminal domain K01008 - 2.7.9.3 1.878e-264 837.0
TLS2_k127_6573140_1 PFAM alpha amylase, catalytic K05343 GO:0000023,GO:0003674,GO:0003824,GO:0004553,GO:0004556,GO:0005488,GO:0005509,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0005991,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009311,GO:0009987,GO:0015980,GO:0016160,GO:0016787,GO:0016798,GO:0016853,GO:0016866,GO:0043167,GO:0043169,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0046872,GO:0047471,GO:0055114,GO:0071704 3.2.1.1,5.4.99.16 2.865e-228 716.0
TLS2_k127_6573140_2 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006517 553.0
TLS2_k127_6573140_3 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009977 470.0
TLS2_k127_6573140_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000002504 129.0
TLS2_k127_6573140_5 Histidine kinase A domain protein - - - 0.0007967 51.0
TLS2_k127_6574169_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 427.0
TLS2_k127_6574169_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000001933 219.0
TLS2_k127_6574169_2 - - - - 0.00000000000000000000000001551 110.0
TLS2_k127_6574169_3 Right handed beta helix region - - - 0.00001293 55.0
TLS2_k127_6574906_0 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 482.0
TLS2_k127_6574906_1 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 465.0
TLS2_k127_6574906_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472,K02474 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046378,GO:0055114,GO:0071704,GO:0089714,GO:1901135,GO:1901137,GO:1901576 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000706 468.0
TLS2_k127_6574906_3 Homocysteine S-methyltransferase K00544,K00548 - 2.1.1.13,2.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 295.0
TLS2_k127_6574906_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000004333 241.0
TLS2_k127_6581193_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K15408 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 509.0
TLS2_k127_6581193_1 COG0451 Nucleoside-diphosphate-sugar epimerases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 354.0
TLS2_k127_6581193_2 Cytochrome C oxidase subunit II, periplasmic domain K02275,K02826 - 1.10.3.12,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 294.0
TLS2_k127_6581193_3 Predicted membrane protein (DUF2231) - - - 0.000000000000000000000000000000000000000000000001235 183.0
TLS2_k127_6581193_4 Uncharacterised protein family (UPF0093) - - - 0.000000000000000000000000000000001925 133.0
TLS2_k127_6583423_0 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 5.883e-262 824.0
TLS2_k127_6583423_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 490.0
TLS2_k127_6583423_2 COG2113 ABC-type proline glycine betaine transport systems periplasmic components K02002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005492 469.0
TLS2_k127_6583423_3 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000324 263.0
TLS2_k127_6583423_4 Acetyltransferase (GNAT) family - - - 0.0000000000000000004008 93.0
TLS2_k127_6583443_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 411.0
TLS2_k127_6583443_1 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 304.0
TLS2_k127_6583443_2 Histidine phosphatase superfamily (branch 1) - - - 0.000000000000000000000000000000000000000000000000000000002093 206.0
TLS2_k127_6584056_0 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 493.0
TLS2_k127_6584056_1 Dehydrogenase E1 component K00161 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 473.0
TLS2_k127_6584056_10 - - - - 0.000000000000000001643 85.0
TLS2_k127_6584056_11 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000004217 83.0
TLS2_k127_6584056_12 peptidase S1 and S6, chymotrypsin Hap - - - 0.0000000000866 70.0
TLS2_k127_6584056_13 Bacterial extracellular solute-binding protein, family 7 K21395 - - 0.0000000001279 63.0
TLS2_k127_6584056_14 Carbamoyltransferase C-terminus K00612 - - 0.00000001899 57.0
TLS2_k127_6584056_15 - - - - 0.000003251 53.0
TLS2_k127_6584056_2 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 471.0
TLS2_k127_6584056_3 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 475.0
TLS2_k127_6584056_4 2-oxoacid dehydrogenases acyltransferase (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 459.0
TLS2_k127_6584056_5 mannitol 2-dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 448.0
TLS2_k127_6584056_6 divalent heavy-metal cations transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009655 296.0
TLS2_k127_6584056_7 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000005096 202.0
TLS2_k127_6584056_8 - - - - 0.000000000000000000000000000000000000004531 150.0
TLS2_k127_6584056_9 - - - - 0.00000000000000000000000000000000009202 142.0
TLS2_k127_6589033_0 Hydrophobe Amphiphile Efflux-1 (HAE1) K03296,K18138,K18299 - - 0.0 1498.0
TLS2_k127_6589033_1 Alpha/beta-hydrolase family - - - 1.805e-234 739.0
TLS2_k127_6589033_2 L-lactate permease K03303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 537.0
TLS2_k127_6589033_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K03778 - 1.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 479.0
TLS2_k127_6589033_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000981 392.0
TLS2_k127_6589033_5 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001008 276.0
TLS2_k127_6589033_6 MAATS-type transcriptional repressor, C-terminal region K03577,K18135 - - 0.000000000000000000000000000000000000000000000000000000000195 210.0
TLS2_k127_6589033_7 VacJ family lipoprotein K04754 - - 0.000000000000000000000000000000000000000000000000000002262 203.0
TLS2_k127_6589033_8 transport system periplasmic component K07080 - - 0.000000000000000000000000000000000000000000000000000003912 204.0
TLS2_k127_6590312_0 (GMC) oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 396.0
TLS2_k127_6590312_1 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000000000000000000000001241 132.0
TLS2_k127_6594308_0 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008714,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464 3.2.2.4 3.388e-207 655.0
TLS2_k127_6594308_1 PFAM EAL domain, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007827 536.0
TLS2_k127_6594308_2 transposase IS116 IS110 IS902 family K07486 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 405.0
TLS2_k127_6594308_3 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008161 385.0
TLS2_k127_6594308_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 344.0
TLS2_k127_6594308_5 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002178 279.0
TLS2_k127_6594308_6 SOS response associated peptidase (SRAP) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002666 245.0
TLS2_k127_6594308_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000003964 147.0
TLS2_k127_6594308_8 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.000000000000000000000000003364 111.0
TLS2_k127_6608047_0 Amidohydrolase family K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 608.0
TLS2_k127_6608047_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 289.0
TLS2_k127_6608047_2 Uncharacterized protein conserved in bacteria (DUF2312) - - - 0.000000000000000000000008242 113.0
TLS2_k127_6613853_0 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 2.511e-211 671.0
TLS2_k127_6613853_1 Aminotransferase class-III K12256 - 2.6.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 581.0
TLS2_k127_6613853_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 474.0
TLS2_k127_6613853_3 Required for the activity of the bacterial periplasmic transport system of putrescine K11069,K11073 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 415.0
TLS2_k127_6613853_4 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 289.0
TLS2_k127_6613853_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000001023 222.0
TLS2_k127_6613853_6 Periplasmic or secreted lipoprotein - - - 0.000000000000000000000000000000000000000006138 160.0
TLS2_k127_6613853_7 VanZ like family - - - 0.00000000000003677 84.0
TLS2_k127_6620203_0 Alpha-amylase domain K01187 - 3.2.1.20 3.735e-252 788.0
TLS2_k127_6620203_1 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 442.0
TLS2_k127_6620203_2 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 430.0
TLS2_k127_6620203_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 415.0
TLS2_k127_6620203_4 molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 303.0
TLS2_k127_6620203_5 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000181 257.0
TLS2_k127_6620203_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000385 248.0
TLS2_k127_6620203_7 COG0558 Phosphatidylglycerophosphate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003717 237.0
TLS2_k127_6620203_8 Biotin/lipoate A/B protein ligase family - - - 0.00000000000000000000000000000000000000000000000000000000000000001533 232.0
TLS2_k127_6620203_9 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000002008 220.0
TLS2_k127_6628263_0 Belongs to the TPP enzyme family K03336 - 3.7.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 459.0
TLS2_k127_6628263_1 PFAM Xylose isomerase-like TIM barrel K03335 - 4.2.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003974 399.0
TLS2_k127_6628506_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 1.212e-281 876.0
TLS2_k127_6628506_1 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 496.0
TLS2_k127_6628506_2 de-polymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005839 323.0
TLS2_k127_6628506_3 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 314.0
TLS2_k127_6628506_4 copG family - - - 0.000000000000000000000000000000000000000000000000000000000002101 211.0
TLS2_k127_6628506_5 Protein of unknown function (DUF533) - - - 0.0000000000000000000000000000000000000000000000002291 187.0
TLS2_k127_6628506_6 Transposase - - - 0.0000001824 58.0
TLS2_k127_6628506_7 Transposase - - - 0.000019 51.0
TLS2_k127_6634083_0 56kDa selenium binding protein (SBP56) K17285 - - 3.431e-199 629.0
TLS2_k127_6634083_1 D-isomer specific 2-hydroxyacid dehydrogenase K00015 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008289 565.0
TLS2_k127_6634083_10 Exopolysaccharide synthesis ExoD - - - 0.000000000000000000000000000000000000000000000000001588 190.0
TLS2_k127_6634083_11 protein conserved in bacteria K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000002286 187.0
TLS2_k127_6634083_12 PFAM electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000000000000000000000009946 179.0
TLS2_k127_6634083_13 Protein of unknown function (DUF533) - - - 0.00000000000000000000000000000000000000002691 160.0
TLS2_k127_6634083_14 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000002869 146.0
TLS2_k127_6634083_15 Protein of unknown function (DUF2384) - - - 0.0000000000000000000000000002817 119.0
TLS2_k127_6634083_16 Domain of unknown function DUF29 - - - 0.0000000000000000000000000003425 119.0
TLS2_k127_6634083_17 RES - - - 0.00000000000000000000000001748 121.0
TLS2_k127_6634083_18 heat shock protein binding K05516 - - 0.00000000004039 65.0
TLS2_k127_6634083_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 550.0
TLS2_k127_6634083_3 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 485.0
TLS2_k127_6634083_4 cell volume homeostasis K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008204 402.0
TLS2_k127_6634083_5 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 363.0
TLS2_k127_6634083_6 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 376.0
TLS2_k127_6634083_7 Thioredoxin reductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002267 286.0
TLS2_k127_6634083_8 PFAM Patatin K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000003565 234.0
TLS2_k127_6634083_9 Periplasmic or secreted lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000001489 219.0
TLS2_k127_6635622_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 5.431e-292 914.0
TLS2_k127_6635622_1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - 0.000000000000000000000000000000000000000000000000000000000000000000002378 237.0
TLS2_k127_6643701_0 TRAP transporter solute receptor TAXI family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 466.0
TLS2_k127_6643701_1 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004697 381.0
TLS2_k127_6643701_2 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 382.0
TLS2_k127_6643701_3 alanine dehydrogenase K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 354.0
TLS2_k127_6643701_4 CopG antitoxin of type II toxin-antitoxin system - - - 0.000000000000000000000000000000000000008092 146.0
TLS2_k127_6643701_5 protein conserved in bacteria K09803 - - 0.00000000000000000000000000000000000007253 144.0
TLS2_k127_6645180_0 Belongs to the ABC transporter superfamily K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 431.0
TLS2_k127_6645180_1 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 292.0
TLS2_k127_6645275_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0 1214.0
TLS2_k127_6645275_1 PEP-utilising enzyme, N-terminal K08484 - 2.7.3.9 1.189e-297 938.0
TLS2_k127_6645275_2 Binding-protein-dependent transport system inner membrane component K02034 - - 9.207e-213 688.0
TLS2_k127_6645275_3 GcpE protein K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 587.0
TLS2_k127_6645275_4 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 552.0
TLS2_k127_6645275_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 582.0
TLS2_k127_6645275_6 Belongs to the ABC transporter superfamily K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 547.0
TLS2_k127_6645275_7 Belongs to the ABC transporter superfamily K02031,K12371 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 504.0
TLS2_k127_6645275_8 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 471.0
TLS2_k127_6645275_9 Domain of unknown function (DUF4115) K15539 - - 0.00000000000000000000000000000000000000002324 171.0
TLS2_k127_6647355_0 CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons K01026 - 2.8.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000902 573.0
TLS2_k127_6647355_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000001139 178.0
TLS2_k127_6647355_2 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000002777 80.0
TLS2_k127_6647355_3 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000001753 64.0
TLS2_k127_6657674_0 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 2.981e-220 689.0
TLS2_k127_6657674_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 499.0
TLS2_k127_6657674_10 - - - - 0.0000000000000006557 90.0
TLS2_k127_6657674_11 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000003015 58.0
TLS2_k127_6657674_2 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005088 429.0
TLS2_k127_6657674_3 dehydrogenase and related dehydrogenases K12972 - 1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 361.0
TLS2_k127_6657674_4 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 327.0
TLS2_k127_6657674_5 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006608 315.0
TLS2_k127_6657674_6 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005927 295.0
TLS2_k127_6657674_7 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009794 278.0
TLS2_k127_6657674_8 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000343 162.0
TLS2_k127_6657674_9 Secreted and surface protein - - - 0.0000000000000000000000000000006908 128.0
TLS2_k127_6669200_0 Periplasmic binding protein K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005264 582.0
TLS2_k127_6669200_1 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007054 556.0
TLS2_k127_6669200_10 PFAM sodium alanine symporter K03310 - - 0.0000000000000000000000000000000003563 132.0
TLS2_k127_6669200_11 Response regulator receiver - - - 0.00000000000000000000000000000000669 133.0
TLS2_k127_6669200_12 HEPN domain - - - 0.0000000001028 74.0
TLS2_k127_6669200_13 Nucleotidyltransferase domain - - - 0.0000000002251 70.0
TLS2_k127_6669200_14 Nucleotidyltransferase domain - - - 0.0000000005618 71.0
TLS2_k127_6669200_2 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 503.0
TLS2_k127_6669200_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 456.0
TLS2_k127_6669200_4 branched-chain amino acid K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003507 437.0
TLS2_k127_6669200_5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000001809 248.0
TLS2_k127_6669200_6 SMART PAS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001661 243.0
TLS2_k127_6669200_7 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000001035 231.0
TLS2_k127_6669200_8 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000001527 168.0
TLS2_k127_6669200_9 - - - - 0.00000000000000000000000000000000000000001212 170.0
TLS2_k127_6673536_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 416.0
TLS2_k127_6673536_1 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000001227 221.0
TLS2_k127_6673536_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000002087 203.0
TLS2_k127_6673536_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000001726 167.0
TLS2_k127_6673536_4 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000001567 165.0
TLS2_k127_6673536_5 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000003496 103.0
TLS2_k127_6674098_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 594.0
TLS2_k127_6674098_1 NAD dependent epimerase/dehydratase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 488.0
TLS2_k127_6674098_2 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain K21826 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 454.0
TLS2_k127_6674098_3 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000001858 125.0
TLS2_k127_6679935_0 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 449.0
TLS2_k127_6679935_1 Acetamidase/Formamidase family K01455 - 3.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005594 420.0
TLS2_k127_6679935_2 PFAM Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 286.0
TLS2_k127_6679935_3 AmiS/UreI family transporter K03191,K22112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000805 261.0
TLS2_k127_6679935_4 Regulatory protein, FmdB family - - - 0.0000000000000001148 93.0
TLS2_k127_6681317_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 2.061e-199 648.0
TLS2_k127_6685493_0 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 378.0
TLS2_k127_6685493_1 Polysulphide reductase, NrfD - - - 0.00000000000004108 77.0
TLS2_k127_6685493_2 - - - - 0.000000003398 66.0
TLS2_k127_6689137_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1251.0
TLS2_k127_6689137_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 337.0
TLS2_k127_6689137_2 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007713 271.0
TLS2_k127_6689137_3 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007751 264.0
TLS2_k127_6689137_4 Dioxygenase K00449 - 1.13.11.3 0.0000000000000000000000000000000000000000000000000000000002145 210.0
TLS2_k127_6689137_5 ATP-independent chaperone mediated protein folding - - - 0.000000000000000000000000000000000000000000002298 181.0
TLS2_k127_6689137_6 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000002482 168.0
TLS2_k127_6689895_0 COG1982 Arginine lysine ornithine decarboxylases K01584 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 551.0
TLS2_k127_6689895_1 Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 432.0
TLS2_k127_6689895_2 Protein of unknown function (DUF2384) - - - 0.00000000000008283 72.0
TLS2_k127_6691967_0 Universal stress protein UspA - - - 0.00000000000000000000000000000000000000000000000006234 191.0
TLS2_k127_6691967_1 Belongs to the peptidase S16 family - - - 0.00000000000000002689 87.0
TLS2_k127_6691967_2 Belongs to the universal stress protein A family - - - 0.0000000000007618 75.0
TLS2_k127_6691967_3 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000359 72.0
TLS2_k127_6693767_0 Proton-conducting membrane transporter K12141 - - 2.361e-234 743.0
TLS2_k127_6693767_1 NADH-ubiquinone oxidoreductase chain 49kDa - - - 4.773e-216 704.0
TLS2_k127_6693767_2 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007149 308.0
TLS2_k127_6693767_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000004223 140.0
TLS2_k127_6698183_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 475.0
TLS2_k127_6698183_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003756 374.0
TLS2_k127_6698183_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 302.0
TLS2_k127_6698183_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 312.0
TLS2_k127_6698183_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000496 87.0
TLS2_k127_672871_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 603.0
TLS2_k127_672871_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 601.0
TLS2_k127_672871_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 363.0
TLS2_k127_672871_11 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 362.0
TLS2_k127_672871_12 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 358.0
TLS2_k127_672871_13 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009579 327.0
TLS2_k127_672871_14 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007949 324.0
TLS2_k127_672871_15 PFAM Ion transport K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 307.0
TLS2_k127_672871_16 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 299.0
TLS2_k127_672871_17 OsmC-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004795 291.0
TLS2_k127_672871_18 TIGRFAM phenazine biosynthesis protein PhzF family K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 289.0
TLS2_k127_672871_19 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006695 305.0
TLS2_k127_672871_2 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 593.0
TLS2_k127_672871_20 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009695 249.0
TLS2_k127_672871_21 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001338 255.0
TLS2_k127_672871_22 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002131 239.0
TLS2_k127_672871_23 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000004876 241.0
TLS2_k127_672871_24 protein with protein kinase and helix-hairpin-helix DNA-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000004031 254.0
TLS2_k127_672871_25 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000009422 243.0
TLS2_k127_672871_26 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000003669 245.0
TLS2_k127_672871_27 Aldolase/RraA - - - 0.0000000000000000000000000000000000000000000000001103 199.0
TLS2_k127_672871_28 Endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000000005112 177.0
TLS2_k127_672871_29 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000001365 178.0
TLS2_k127_672871_3 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K10764 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 511.0
TLS2_k127_672871_30 Membrane K15977 - - 0.00000000000000000000000000000000000000000000121 169.0
TLS2_k127_672871_31 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000001766 169.0
TLS2_k127_672871_32 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000008989 171.0
TLS2_k127_672871_33 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000001589 159.0
TLS2_k127_672871_34 - - - - 0.000000000000000000000000000000000000000002366 159.0
TLS2_k127_672871_35 Protein phosphatase 2C - - - 0.000000000000000000000000000000000000001291 160.0
TLS2_k127_672871_36 Uncharacterised protein family (UPF0149) K07039 - - 0.0000000000000000000000000000000000002333 154.0
TLS2_k127_672871_37 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000101 147.0
TLS2_k127_672871_38 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000006395 119.0
TLS2_k127_672871_39 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000009303 98.0
TLS2_k127_672871_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038,K21977 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 509.0
TLS2_k127_672871_40 Domain of unknown function (DUF1127) - - - 0.00000108 53.0
TLS2_k127_672871_41 - - - - 0.000001405 54.0
TLS2_k127_672871_5 Bacterial extracellular solute-binding protein K02055 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 447.0
TLS2_k127_672871_6 COG0303 Molybdopterin biosynthesis enzyme K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 443.0
TLS2_k127_672871_7 (GMC) oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003527 447.0
TLS2_k127_672871_8 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 428.0
TLS2_k127_672871_9 helix_turn_helix gluconate operon transcriptional repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004284 395.0
TLS2_k127_6735258_0 Cys/Met metabolism PLP-dependent enzyme K00652,K00654 - 2.3.1.47,2.3.1.50 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 439.0
TLS2_k127_6735258_1 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000001598 217.0
TLS2_k127_6735258_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000001952 164.0
TLS2_k127_6735258_3 Acyl carrier protein - - - 0.00000000000000278 81.0
TLS2_k127_6735258_4 AMP-binding enzyme K00666 - - 0.000000001964 59.0
TLS2_k127_6737908_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009804 346.0
TLS2_k127_6737908_1 Beta-lactamase superfamily domain K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 329.0
TLS2_k127_6737908_2 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005525 314.0
TLS2_k127_6737908_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000003264 240.0
TLS2_k127_6737908_4 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000004045 124.0
TLS2_k127_6741046_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 1.755e-273 848.0
TLS2_k127_6741046_1 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 350.0
TLS2_k127_6750678_0 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008587 465.0
TLS2_k127_6750678_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 300.0
TLS2_k127_6750678_2 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.00000000000000000000000000000000000000005769 158.0
TLS2_k127_6753022_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008966 593.0
TLS2_k127_6753022_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 572.0
TLS2_k127_6753022_10 Polysaccharide polymerase - - - 0.000000000001949 79.0
TLS2_k127_6753022_11 ABC-2 family transporter protein K01992 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944 - 0.0000000005498 63.0
TLS2_k127_6753022_2 glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 540.0
TLS2_k127_6753022_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 490.0
TLS2_k127_6753022_4 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 471.0
TLS2_k127_6753022_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 353.0
TLS2_k127_6753022_6 Glycosyltransferase family 28 C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008701 293.0
TLS2_k127_6753022_7 Belongs to the glycosyltransferase 26 family K05946 - 2.4.1.187 0.000000000000000000000000000000000000000000000000000000000149 215.0
TLS2_k127_6753022_8 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000002571 170.0
TLS2_k127_6753022_9 polysaccharide deacetylase - - - 0.000000000000000000000000002254 118.0
TLS2_k127_6753876_0 fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 465.0
TLS2_k127_6753876_1 PFAM Integrase catalytic region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 369.0
TLS2_k127_6753876_2 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 292.0
TLS2_k127_6753876_3 Transposase, Mutator family - - - 0.00000000000000000000000000000000005032 138.0
TLS2_k127_6753876_4 - - - - 0.00000000000000000000000000000000006297 138.0
TLS2_k127_6753876_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000048 78.0
TLS2_k127_6753876_6 Transposase, Mutator family - - - 0.00000000000005403 75.0
TLS2_k127_6753876_7 Transposase, Mutator family - - - 0.0000000000007408 75.0
TLS2_k127_6753876_8 - - - - 0.000000006388 61.0
TLS2_k127_6753876_9 Histidine kinase-like ATPase domain - - - 0.00000002121 64.0
TLS2_k127_6756910_0 ABC transporter transmembrane region K12541 - - 1.731e-259 823.0
TLS2_k127_6756910_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 563.0
TLS2_k127_6756910_10 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000001243 181.0
TLS2_k127_6756910_11 EVE domain - - - 0.00000000000000000000000000000000000000000000007978 176.0
TLS2_k127_6756910_12 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000004935 175.0
TLS2_k127_6756910_13 - - - - 0.0000000000000000000000000000000000000000002841 169.0
TLS2_k127_6756910_14 COG4942 Membrane-bound metallopeptidase - - - 0.00000000000000000000000003213 124.0
TLS2_k127_6756910_2 Outer membrane efflux protein K12543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 450.0
TLS2_k127_6756910_3 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003104 323.0
TLS2_k127_6756910_4 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 306.0
TLS2_k127_6756910_5 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 304.0
TLS2_k127_6756910_6 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003824 290.0
TLS2_k127_6756910_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000336 272.0
TLS2_k127_6756910_8 Divergent polysaccharide deacetylase K09798 - - 0.0000000000000000000000000000000000000000000000000000000004878 214.0
TLS2_k127_6756910_9 HlyD family secretion protein K02022,K12542 - - 0.0000000000000000000000000000000000000000000000000007354 190.0
TLS2_k127_6758499_0 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 584.0
TLS2_k127_6758499_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 323.0
TLS2_k127_6758499_2 COG0698 Ribose 5-phosphate isomerase RpiB K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000006132 198.0
TLS2_k127_6758499_3 PFAM Glycosyl transferase family 2 K16649 - 2.4.1.287 0.00000000000000000000000000000000003019 149.0
TLS2_k127_6758499_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000004763 83.0
TLS2_k127_6767282_0 Proton-conducting membrane transporter - - - 4.694e-283 884.0
TLS2_k127_6767282_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 1.132e-261 819.0
TLS2_k127_6767282_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 401.0
TLS2_k127_6767282_3 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002326 266.0
TLS2_k127_6767282_4 Putative transmembrane protein (Alph_Pro_TM) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001837 260.0
TLS2_k127_6767282_5 universal stress protein UspA and related nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000004554 188.0
TLS2_k127_6767282_6 NADH dehydrogenase - - - 0.0000000000000000000000004622 122.0
TLS2_k127_6783968_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 422.0
TLS2_k127_6783968_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000009417 216.0
TLS2_k127_6783968_2 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000005753 52.0
TLS2_k127_6787402_0 ABC-type dipeptide transport system, periplasmic component K02035 - - 5.911e-251 785.0
TLS2_k127_6787402_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007573 455.0
TLS2_k127_6787402_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000002341 113.0
TLS2_k127_6795362_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 495.0
TLS2_k127_6799851_0 MacB-like periplasmic core domain K02004 - - 4.28e-262 830.0
TLS2_k127_6799851_1 PFAM DNA methylase N-4 N-6 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 546.0
TLS2_k127_6799851_10 - - - - 0.00000000000001914 76.0
TLS2_k127_6799851_11 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21563 - - 0.00000000009454 68.0
TLS2_k127_6799851_12 Terminase K21512 - 3.1.21.4 0.00000007665 58.0
TLS2_k127_6799851_13 - - - - 0.00000546 48.0
TLS2_k127_6799851_14 Short-chain dehydrogenase reductase SDR - - - 0.0002204 49.0
TLS2_k127_6799851_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 395.0
TLS2_k127_6799851_3 ATPases associated with a variety of cellular activities K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 337.0
TLS2_k127_6799851_4 hydrolases or acyltransferases, alpha beta hydrolase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001131 285.0
TLS2_k127_6799851_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000003458 229.0
TLS2_k127_6799851_6 Transposase DDE domain - - - 0.0000000000000000000000000000000000000000002615 161.0
TLS2_k127_6799851_7 PFAM NnrS family protein - - - 0.00000000000000000000000000000000000000002467 169.0
TLS2_k127_6799851_8 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21563 - - 0.000000000000000000000000000000000000001053 160.0
TLS2_k127_6799851_9 Terminase K21512 - 3.1.21.4 0.0000000000000000001802 94.0
TLS2_k127_6807_0 COG0530 Ca2 Na antiporter K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 304.0
TLS2_k127_6807_1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000047 280.0
TLS2_k127_6807_2 Belongs to the globin family K05916 - 1.14.12.17 0.000000000000000000000000000000000003163 144.0
TLS2_k127_6807_3 Sel1 domain protein repeat-containing protein K07126 - - 0.000000000000000000001685 98.0
TLS2_k127_6807_4 polysaccharide deacetylase - - - 0.00002996 53.0
TLS2_k127_6817588_0 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 331.0
TLS2_k127_6817588_1 COG0768 Cell division protein FtsI penicillin-binding protein 2 K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000002462 235.0
TLS2_k127_6817588_2 periplasmic protein - - - 0.0000006835 61.0
TLS2_k127_6818594_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 348.0
TLS2_k127_6818594_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006912 270.0
TLS2_k127_6818594_2 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000000001016 98.0
TLS2_k127_6818800_0 Sodium/hydrogen exchanger family K03316 - - 1.213e-257 819.0
TLS2_k127_6818800_1 E-Z type HEAT repeats - - - 0.00000000000000000000000000000000000002981 153.0
TLS2_k127_6818800_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000008073 150.0
TLS2_k127_6833769_0 KR domain - - - 0.0000000000000000000000000000000000000000000000000002326 197.0
TLS2_k127_6833769_1 Protein of unknown function DUF45 K07043 - - 0.0000000000000000000000000000000000000000001184 168.0
TLS2_k127_6833769_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000003428 130.0
TLS2_k127_6842851_0 PFAM plasmid encoded RepA protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009187 248.0
TLS2_k127_6842851_1 PFAM Gp37Gp68 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000001383 229.0
TLS2_k127_6842851_2 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000001209 139.0
TLS2_k127_6842851_3 - - - - 0.0000000000001814 76.0
TLS2_k127_6842851_4 - - - - 0.00000008931 60.0
TLS2_k127_6844861_0 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 399.0
TLS2_k127_6844861_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006811 282.0
TLS2_k127_6844861_2 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002238 295.0
TLS2_k127_6844861_3 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000001229 232.0
TLS2_k127_6844861_4 - - - - 0.000000000000000000000000000000003024 141.0
TLS2_k127_6844861_5 Protein of unknown function DUF126 K09128 - - 0.000000000000000000000000000000003884 136.0
TLS2_k127_6844861_6 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000001894 115.0
TLS2_k127_6844861_7 Domain of unknown function (DUF1476) - - - 0.0000000000000000000000003491 119.0
TLS2_k127_6844861_8 Protein of unknown function (DUF3096) - - - 0.00000000006293 64.0
TLS2_k127_6852458_0 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007175 352.0
TLS2_k127_6852458_1 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002759 340.0
TLS2_k127_6869837_0 DNA photolyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004469 440.0
TLS2_k127_6869837_1 PFAM Integrase catalytic region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001162 265.0
TLS2_k127_6886072_0 Transposase and inactivated - - - 0.0000000000000000000000000000000000000000000000000000000000000009539 226.0
TLS2_k127_6886072_1 - - - - 0.0000000000000000000009324 97.0
TLS2_k127_6886072_2 Transposase - - - 0.0000000000000000003123 94.0
TLS2_k127_6886072_3 - - - - 0.0000000000001778 81.0
TLS2_k127_6886072_4 L COG4584 Transposase and inactivated derivatives - - - 0.00000005197 55.0
TLS2_k127_6886072_5 Putative transposase of IS4/5 family (DUF4096) K07492 - - 0.0000001457 57.0
TLS2_k127_6886762_0 LUD domain K18929 - - 4.937e-202 640.0
TLS2_k127_6886762_1 membrane-bound lytic murein transglycosylase K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 386.0
TLS2_k127_6886762_2 (Fe-S) oxidoreductase K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 350.0
TLS2_k127_6886762_3 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000004951 227.0
TLS2_k127_6886762_4 LUD domain K00782 - - 0.00000000000000000000000000000000000000000000351 186.0
TLS2_k127_6886762_5 protein conserved in bacteria - - - 0.000000000000000000000000000000000000001032 158.0
TLS2_k127_6886762_6 GIY-YIG catalytic domain K07461 - - 0.0000000000000000000000000000000000001295 145.0
TLS2_k127_6886762_7 COG3030 Protein affecting phage T7 exclusion by the F plasmid K07113 - - 0.00000000000000000000000000001395 124.0
TLS2_k127_6888272_0 transport system, permease component K05778 - - 2.713e-195 623.0
TLS2_k127_6888272_1 transport system periplasmic component K05777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 543.0
TLS2_k127_6888272_10 3-methyladenine DNA glycosylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005883 279.0
TLS2_k127_6888272_11 transport system, ATPase component K05779 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001278 267.0
TLS2_k127_6888272_12 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000006766 160.0
TLS2_k127_6888272_13 2'-5' RNA ligase superfamily K01975 - 3.1.4.58 0.00000000000000000000000000000000000000003873 157.0
TLS2_k127_6888272_14 Lipid A Biosynthesis N-terminal domain - - - 0.00000000000000000000000000000000007269 137.0
TLS2_k127_6888272_15 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000001304 129.0
TLS2_k127_6888272_16 cytochrome - - - 0.00000000000000000459 91.0
TLS2_k127_6888272_2 ATPase component of ABC-type sugar transporter K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 517.0
TLS2_k127_6888272_3 COG0395 ABC-type sugar transport system, permease component K17317 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 471.0
TLS2_k127_6888272_4 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000029 481.0
TLS2_k127_6888272_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 473.0
TLS2_k127_6888272_6 PQQ-like domain K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 443.0
TLS2_k127_6888272_7 CoA-binding domain K03606,K20997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 406.0
TLS2_k127_6888272_8 COG2041 Sulfite oxidase and related enzymes K00387 - 1.8.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 308.0
TLS2_k127_6888272_9 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009632 309.0
TLS2_k127_6896737_0 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 453.0
TLS2_k127_6896737_1 Dipeptide transport system permease protein DppC K02034 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 338.0
TLS2_k127_6896737_2 HWE histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008077 321.0
TLS2_k127_6896737_3 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000003457 246.0
TLS2_k127_6932576_0 Bacterial extracellular solute-binding protein - - - 2.468e-219 700.0
TLS2_k127_6932576_1 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 460.0
TLS2_k127_6932576_2 SMP-30/Gluconolaconase/LRE-like region K01053,K14274 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 305.0
TLS2_k127_6948244_0 RmlD substrate binding domain K01784 - 5.1.3.2 0.000000000000000000000000000000001431 135.0
TLS2_k127_6948244_1 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000002232 126.0
TLS2_k127_69603_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 3.128e-292 906.0
TLS2_k127_69603_1 Transketolase, pyrimidine binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 543.0
TLS2_k127_69603_2 Dehydrogenase E1 component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006952 476.0
TLS2_k127_69603_3 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009637 433.0
TLS2_k127_69603_4 Formate/nitrite transporter K06212,K21993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003727 265.0
TLS2_k127_69603_5 Protein conserved in bacteria - - - 0.00000000000000000000000000000001038 132.0
TLS2_k127_69603_6 Phosphopantetheine attachment site - - - 0.0000000000000000001007 104.0
TLS2_k127_6962345_0 FAD binding domain K11472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009596 320.0
TLS2_k127_6962345_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 300.0
TLS2_k127_6982745_0 dihydroorotase K01464,K01466 - 3.5.2.2,3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 505.0
TLS2_k127_6982745_1 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 478.0
TLS2_k127_6982745_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 396.0
TLS2_k127_6982745_3 Serine aminopeptidase, S33 - - - 0.0000000000000000000000001505 109.0
TLS2_k127_6982745_4 Aconitase C-terminal domain K01681 - 4.2.1.3 0.00000000000000002437 82.0
TLS2_k127_6986319_0 Adenylate cyclase - - - 6.475e-296 921.0
TLS2_k127_6986319_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 4.185e-204 646.0
TLS2_k127_6986319_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 433.0
TLS2_k127_6986319_3 Belongs to the N(4) N(6)-methyltransferase family - - - 0.0000000000001949 71.0
TLS2_k127_6986319_4 DNA methylase - - - 0.00002848 47.0
TLS2_k127_69868_0 AMP-binding enzyme C-terminal domain - - - 5.407e-197 627.0
TLS2_k127_69868_1 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000328 206.0
TLS2_k127_69868_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000009828 178.0
TLS2_k127_69868_3 transcriptional regulator, ArsR family - - - 0.00000000000000000000000000000000000000000000008899 171.0
TLS2_k127_69868_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000009418 158.0
TLS2_k127_69868_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000005986 99.0
TLS2_k127_698806_0 Belongs to the 5'-nucleotidase family K01081,K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 519.0
TLS2_k127_698806_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 315.0
TLS2_k127_698806_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000002808 255.0
TLS2_k127_698806_3 Domain of unknown function (DUF1902) - - - 0.00000000001219 78.0
TLS2_k127_698806_4 Belongs to the 'phage' integrase family - - - 0.0003026 49.0
TLS2_k127_7009826_0 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 352.0
TLS2_k127_7009826_1 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.000000000000006906 82.0
TLS2_k127_7009826_2 IstB-like ATP binding protein - - - 0.00000000001555 75.0
TLS2_k127_7009826_3 Transposase - - - 0.00000009906 58.0
TLS2_k127_7064063_0 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006148 368.0
TLS2_k127_7064063_1 Cytochrome C oxidase, mono-heme subunit/FixO K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 332.0
TLS2_k127_7064063_2 PFAM Antibiotic biosynthesis monooxygenase - - - 0.0000000000002777 70.0
TLS2_k127_7064063_3 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.0000000004878 64.0
TLS2_k127_7065587_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00819 - 2.6.1.13 5.262e-214 676.0
TLS2_k127_7065587_1 Glutathione S-transferase K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 521.0
TLS2_k127_7065587_10 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000002991 185.0
TLS2_k127_7065587_11 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000004364 150.0
TLS2_k127_7065587_12 DnaJ C terminal domain - - - 0.0000000000000000000000000000001096 127.0
TLS2_k127_7065587_13 - - - - 0.000000000000000000000000001109 124.0
TLS2_k127_7065587_14 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000005722 103.0
TLS2_k127_7065587_15 O-Antigen ligase - - - 0.000000000000007154 88.0
TLS2_k127_7065587_16 EAL domain K13593 - - 0.0000000002203 72.0
TLS2_k127_7065587_18 SMART Tetratricopeptide domain protein - - - 0.0000455 56.0
TLS2_k127_7065587_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 473.0
TLS2_k127_7065587_3 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 440.0
TLS2_k127_7065587_4 Male sterility protein K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 401.0
TLS2_k127_7065587_5 Substrate binding domain of ABC-type glycine betaine transport system K02002 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008977 383.0
TLS2_k127_7065587_6 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 348.0
TLS2_k127_7065587_7 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008969 347.0
TLS2_k127_7065587_8 belongs to the wrba family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 323.0
TLS2_k127_7065587_9 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000000000000000000009398 219.0
TLS2_k127_7089627_0 Cytochrome D1 heme domain - - - 3.429e-194 635.0
TLS2_k127_7089627_1 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 602.0
TLS2_k127_7089627_2 transcriptional regulator AsnC family - - - 0.00000000000000000000000000000000000000007591 152.0
TLS2_k127_7089627_3 sirohydrochlorin cobaltochelatase activity K03795 - 4.99.1.3 0.00000000000000000004233 100.0
TLS2_k127_7090771_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006342 521.0
TLS2_k127_7090771_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000472 167.0
TLS2_k127_7093947_0 Glycogen debranching enzyme - - - 0.0 1237.0
TLS2_k127_7093947_1 Adenylate cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 351.0
TLS2_k127_7093947_2 Predicted periplasmic protein (DUF2092) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002206 288.0
TLS2_k127_7093947_3 Cysteine rich repeat - - - 0.00000000000000000000000000000001158 132.0
TLS2_k127_7093947_4 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000007129 131.0
TLS2_k127_7093947_5 Glycine-zipper domain - - - 0.0000000000000000000000000003871 123.0
TLS2_k127_7093947_6 Belongs to the ompA family - - - 0.000000000000000000000000522 112.0
TLS2_k127_7093947_7 - - - - 0.0000000000000002438 91.0
TLS2_k127_7093947_8 mechanosensitive ion channel K22044 - - 0.000000002194 59.0
TLS2_k127_709799_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000002521 143.0
TLS2_k127_709799_1 PFAM Prenyltransferase squalene oxidase - - - 0.0000000000000000000001888 108.0
TLS2_k127_7110610_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 9.32e-294 911.0
TLS2_k127_7110610_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 3.934e-221 691.0
TLS2_k127_7110610_2 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 527.0
TLS2_k127_7110610_3 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 454.0
TLS2_k127_7110610_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 438.0
TLS2_k127_7110610_5 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 430.0
TLS2_k127_7110610_6 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000000313 183.0
TLS2_k127_7110610_7 Belongs to the BolA IbaG family - - - 0.00000000000000000000000001676 114.0
TLS2_k127_7110610_8 Protein of unknown function (DUF3108) - - - 0.00000001621 66.0
TLS2_k127_7123890_0 Uncharacterized protein conserved in bacteria (DUF2090) K03338 - 2.7.1.92 1.165e-228 725.0
TLS2_k127_7123890_1 Phosphoenolpyruvate carboxylase K01595 - 4.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 520.0
TLS2_k127_7123890_2 Oxidoreductase family, C-terminal alpha/beta domain K00010 - 1.1.1.18,1.1.1.369 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 407.0
TLS2_k127_7149205_0 DNA ligase K01971 - 6.5.1.1 4.232e-250 799.0
TLS2_k127_7149205_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.655e-223 709.0
TLS2_k127_7149205_2 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 546.0
TLS2_k127_7149205_3 Phosphoenolpyruvate carboxylase K01595 - 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 523.0
TLS2_k127_7149205_4 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 434.0
TLS2_k127_7149205_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 317.0
TLS2_k127_7149205_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008793 328.0
TLS2_k127_7149205_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000001376 234.0
TLS2_k127_7149205_8 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.000000000000000000000000000000202 134.0
TLS2_k127_7149205_9 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000007511 120.0
TLS2_k127_7160042_0 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 501.0
TLS2_k127_7160042_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 289.0
TLS2_k127_7160042_2 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000009267 175.0
TLS2_k127_7160042_3 Uncharacterized conserved protein (DUF2267) - - - 0.000000000000000000000000000000000000000000002136 175.0
TLS2_k127_7160042_4 - - - - 0.00000000000000000000000000002383 118.0
TLS2_k127_7160042_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000001181 117.0
TLS2_k127_71698_0 Penicillin-binding protein 2 K05515 - 3.4.16.4 1.806e-221 702.0
TLS2_k127_71698_1 Rod shape-determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 605.0
TLS2_k127_71698_10 Protein of unknown function (DUF2390) - - - 0.00000000000000000000001653 111.0
TLS2_k127_71698_11 shape-determining protein K03571 - - 0.000000000000000000002521 109.0
TLS2_k127_71698_12 Small protein - - - 0.0000000004044 64.0
TLS2_k127_71698_13 Protein of unknown function (DUF465) - - - 0.00000007387 59.0
TLS2_k127_71698_2 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850,K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 526.0
TLS2_k127_71698_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 491.0
TLS2_k127_71698_4 ATPases associated with a variety of cellular activities K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003624 367.0
TLS2_k127_71698_5 AAA domain, putative AbiEii toxin, Type IV TA system K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009546 310.0
TLS2_k127_71698_6 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002015 270.0
TLS2_k127_71698_7 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000485 271.0
TLS2_k127_71698_8 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000001066 239.0
TLS2_k127_71698_9 Transcriptional activator HlyU - - - 0.000000000000000000000003385 104.0
TLS2_k127_7174423_0 AMP-binding enzyme K01897 - 6.2.1.3 2.466e-226 731.0
TLS2_k127_7174423_1 Aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 3.88e-210 666.0
TLS2_k127_7174423_2 Isocitrate/isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 540.0
TLS2_k127_7174423_3 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005166 344.0
TLS2_k127_7174423_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003187 317.0
TLS2_k127_7174423_5 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000128 99.0
TLS2_k127_7188132_0 PFAM AMP-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 506.0
TLS2_k127_7188132_1 diguanylate cyclase K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.00000000000000000000000000000000001333 152.0
TLS2_k127_719908_0 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 470.0
TLS2_k127_719908_1 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 424.0
TLS2_k127_719908_2 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009595 310.0
TLS2_k127_719908_3 Predicted integral membrane protein (DUF2270) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001698 248.0
TLS2_k127_719908_4 Protein of unknown function (DUF3299) K09950 - - 0.000000000000000000001968 102.0
TLS2_k127_7209298_0 malic enzyme K00029 - 1.1.1.40 1.278e-271 846.0
TLS2_k127_7209298_1 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 362.0
TLS2_k127_7209298_2 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009656 301.0
TLS2_k127_7209298_3 ABC transporter K02056,K10545 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 308.0
TLS2_k127_7209298_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000399 218.0
TLS2_k127_7209298_5 Pfam:Pyridox_oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000001271 222.0
TLS2_k127_7209298_6 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000000000000000000000000000000000000000000000000003562 207.0
TLS2_k127_7209298_7 Binding-protein-dependent transport system inner membrane component K02026 - - 0.0000000000000000000000000000000000000000000001345 168.0
TLS2_k127_7209298_8 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000000000000000000000000000095 169.0
TLS2_k127_7214966_0 Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 438.0
TLS2_k127_7214966_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004263 370.0
TLS2_k127_7214966_2 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001854 242.0
TLS2_k127_7214966_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000009154 162.0
TLS2_k127_7295417_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000001256 235.0
TLS2_k127_7295417_1 Amidase - - - 0.00000000000000000000000000000000000000000000000000000000001859 220.0
TLS2_k127_7304381_0 NMT1-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 364.0
TLS2_k127_7304381_1 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000001489 239.0
TLS2_k127_7305469_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - 0.0 1234.0
TLS2_k127_7305469_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006996 456.0
TLS2_k127_7305469_2 Uncharacterised MFS-type transporter YbfB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 351.0
TLS2_k127_7305469_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000036 256.0
TLS2_k127_7305469_4 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000007701 221.0
TLS2_k127_7305469_5 Membrane-bound serine protease (ClpP class) K07403 - - 0.0000000000000000000002212 100.0
TLS2_k127_7305469_6 Arylesterase - - - 0.0003362 49.0
TLS2_k127_731171_0 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 289.0
TLS2_k127_731171_1 Glycosyl hydrolases family 15 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001874 279.0
TLS2_k127_731171_2 HWE histidine kinase - - - 0.00000000000000000000000000000000000027 160.0
TLS2_k127_7354034_0 Isocitrate/isopropylmalate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 505.0
TLS2_k127_7354034_1 COG0010 Arginase agmatinase formimionoglutamate hydrolase, arginase family K18459 - 3.5.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 481.0
TLS2_k127_7354034_10 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000000000000009644 176.0
TLS2_k127_7354034_11 Hemimethylated DNA-binding protein YccV like K11940 - - 0.0000000000000000000000000000000000000000003805 164.0
TLS2_k127_7354034_12 Belongs to the ompA family - - - 0.000000000000000000001027 103.0
TLS2_k127_7354034_13 MerR HTH family regulatory protein K18997 - - 0.000000000000000000006974 96.0
TLS2_k127_7354034_2 Alanine-glyoxylate amino-transferase K00375,K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009148 484.0
TLS2_k127_7354034_3 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 449.0
TLS2_k127_7354034_4 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 397.0
TLS2_k127_7354034_5 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000484 287.0
TLS2_k127_7354034_6 PFAM Rhomboid family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006473 259.0
TLS2_k127_7354034_7 Uncharacterized BCR, YaiI/YqxD family COG1671 K09768 - - 0.000000000000000000000000000000000000000000000000000001574 195.0
TLS2_k127_7354034_8 - - - - 0.00000000000000000000000000000000000000000000000003123 187.0
TLS2_k127_7354034_9 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000004616 190.0
TLS2_k127_7387906_0 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 6.716e-195 618.0
TLS2_k127_7387906_1 Uncharacterized protein family UPF0004 K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008502 511.0
TLS2_k127_7387906_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 411.0
TLS2_k127_7387906_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008572 319.0
TLS2_k127_7387906_4 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000001098 260.0
TLS2_k127_7387906_5 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000002911 186.0
TLS2_k127_7387906_6 COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000000000000001633 175.0
TLS2_k127_7387906_7 PRC-barrel domain - - - 0.0000000000000000000000000000000000000000000000713 174.0
TLS2_k127_7387906_8 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.00000000000000000000000000000000000000000008076 165.0
TLS2_k127_7387906_9 protein conserved in bacteria - - - 0.0000000000000000000000000000000002116 138.0
TLS2_k127_7389_0 Polysaccharide biosynthesis protein K13013 - - 5.15e-204 655.0
TLS2_k127_7389_1 Plasmid encoded RepA protein K08282 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004484 370.0
TLS2_k127_7389_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001134 282.0
TLS2_k127_7389_3 - - - - 0.000000005776 64.0
TLS2_k127_7455292_0 COG4584 Transposase and inactivated derivatives - - - 4.625e-221 696.0
TLS2_k127_7455292_1 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 474.0
TLS2_k127_7455292_2 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 310.0
TLS2_k127_7455292_3 Resolvase, N terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002295 249.0
TLS2_k127_7455292_4 COG2801 Transposase and inactivated derivatives K07497 - - 0.000000000000000000000000000000001703 131.0
TLS2_k127_7455292_5 Protein of unknown function DUF86 - - - 0.00000000005603 75.0
TLS2_k127_7455292_6 - - - - 0.0002535 50.0
TLS2_k127_7458964_0 Isocitrate/isopropylmalate dehydrogenase K00031,K00052,K07246 - 1.1.1.42,1.1.1.83,1.1.1.85,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007294 388.0
TLS2_k127_7458964_1 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 353.0
TLS2_k127_7458964_2 ammonia monooxygenase K07120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001478 274.0
TLS2_k127_7458964_3 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000001114 201.0
TLS2_k127_777843_0 Transposase IS116/IS110/IS902 family K07486 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007862 391.0
TLS2_k127_777843_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000009481 190.0
TLS2_k127_777843_2 Trap-type c4-dicarboxylate transport system, small permease component K11689 - - 0.000000000000000000000000000001327 130.0
TLS2_k127_787546_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 323.0
TLS2_k127_787546_1 C4-dicarboxylate anaerobic carrier - - - 0.000000000000000000000000000000002497 130.0
TLS2_k127_78968_0 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 317.0
TLS2_k127_78968_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002951 279.0
TLS2_k127_78968_2 lactoylglutathione lyase activity K01239 - 3.2.2.1 0.00000000000000000000000000000000000002515 149.0
TLS2_k127_79314_0 Protein of unknown function, DUF255 K06888 - - 8.676e-249 790.0
TLS2_k127_79314_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 4.611e-220 691.0
TLS2_k127_79314_10 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000000000000001112 238.0
TLS2_k127_79314_11 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000000000000000000008407 160.0
TLS2_k127_79314_12 Uncharacterised protein family (UPF0093) K08973 - - 0.0000000000000000000000000000000000000000009653 160.0
TLS2_k127_79314_13 FtsZ-dependent cytokinesis - - - 0.0000000000000000000000000000000000005547 153.0
TLS2_k127_79314_2 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 481.0
TLS2_k127_79314_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007512 409.0
TLS2_k127_79314_4 Cys/Met metabolism PLP-dependent enzyme K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 383.0
TLS2_k127_79314_5 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 371.0
TLS2_k127_79314_6 Chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 364.0
TLS2_k127_79314_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 373.0
TLS2_k127_79314_8 TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 350.0
TLS2_k127_79314_9 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007326 309.0
TLS2_k127_82487_0 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 473.0
TLS2_k127_82487_1 PFAM Uncharacterised BCR, COG1649 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005239 449.0
TLS2_k127_82487_10 ThiS family K03154 - - 0.0000003175 63.0
TLS2_k127_82487_11 PFAM UspA domain protein - - - 0.0000006385 58.0
TLS2_k127_82487_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 372.0
TLS2_k127_82487_3 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 309.0
TLS2_k127_82487_4 Enoyl-(Acyl carrier protein) reductase K07535 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002233 275.0
TLS2_k127_82487_5 thiamine-phosphate diphosphorylase activity K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000001611 192.0
TLS2_k127_82487_6 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000007896 161.0
TLS2_k127_82487_7 PFAM PBS lyase HEAT domain protein - - - 0.0000000000000000000000000000000000000002026 149.0
TLS2_k127_82487_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000009554 142.0
TLS2_k127_82487_9 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000004073 140.0
TLS2_k127_83632_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 621.0
TLS2_k127_83632_1 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter MnhD subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 438.0
TLS2_k127_83632_2 Domain related to MnhB subunit of Na+/H+ antiporter - - - 0.0000000000000000000000000000000000000000000000000000000000000001026 239.0
TLS2_k127_83632_3 monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000006435 106.0
TLS2_k127_83632_4 antiporter activity K05570 - - 0.00000000000000000000008042 102.0
TLS2_k127_83632_5 Multisubunit Na H antiporter MnhC subunit K05567 - - 0.00000000000000000008144 103.0
TLS2_k127_840899_0 4Fe-4S dicluster domain - - - 6.898e-277 869.0
TLS2_k127_840899_1 AAA domain, putative AbiEii toxin, Type IV TA system K02028,K10025 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 374.0
TLS2_k127_840899_10 - - - - 0.000001567 59.0
TLS2_k127_840899_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 367.0
TLS2_k127_840899_3 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 305.0
TLS2_k127_840899_4 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000156 301.0
TLS2_k127_840899_5 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000644 260.0
TLS2_k127_840899_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001398 238.0
TLS2_k127_840899_7 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000008053 232.0
TLS2_k127_840899_9 Glycosyl transferase, family 2 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.00000000000000000000000000000000002701 146.0
TLS2_k127_861517_0 Transposase (IS66 K07484 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009622 435.0
TLS2_k127_870181_0 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 490.0
TLS2_k127_910018_0 COG0739 Membrane proteins related to metalloendopeptidases K06194 - - 0.0000000000000000000000000000000000000000000000000000000000003758 226.0
TLS2_k127_910018_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000005261 118.0
TLS2_k127_91532_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 597.0
TLS2_k127_91532_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 482.0
TLS2_k127_91532_10 OstA-like protein K09774 - - 0.0000000000000000000000000000000000001548 151.0
TLS2_k127_91532_11 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.00000000000000000000000000000008287 139.0
TLS2_k127_91532_12 COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism K06023 - - 0.000000000000000000000000000001349 130.0
TLS2_k127_91532_13 PTS HPr component phosphorylation site K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006808,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0044424,GO:0044464,GO:0050789,GO:0051179,GO:0051234,GO:0065007,GO:0071702 - 0.000000000000000000000003755 104.0
TLS2_k127_91532_2 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 404.0
TLS2_k127_91532_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 400.0
TLS2_k127_91532_4 ABC transporter, ATP-binding protein K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000063 392.0
TLS2_k127_91532_5 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 354.0
TLS2_k127_91532_6 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003582 291.0
TLS2_k127_91532_7 O-Antigen ligase - - - 0.000000000000000000000000000000000000000000000000000000000000000008664 244.0
TLS2_k127_91532_8 PTS system fructose IIA component K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000004246 191.0
TLS2_k127_91532_9 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.0000000000000000000000000000000000000000000131 166.0
TLS2_k127_915424_0 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 GO:0000287,GO:0003674,GO:0003824,GO:0004016,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016020,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0023052,GO:0030145,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052652,GO:0055086,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 310.0
TLS2_k127_915424_1 transposase activity - - - 0.0000000000000000000000000000000000000000000000000867 185.0
TLS2_k127_934200_0 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 475.0
TLS2_k127_934200_1 TOBE domain K02010,K02052 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 465.0
TLS2_k127_934200_2 PFAM UspA domain protein - - - 0.000000000000006658 85.0
TLS2_k127_935489_0 COG1138 Cytochrome c biogenesis factor K02198 - - 1.954e-248 782.0
TLS2_k127_935489_1 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008388 543.0
TLS2_k127_935489_2 transport system periplasmic component K07080 - - 0.00000000000000000000000000000000000000000000000000000000000001717 220.0
TLS2_k127_935489_3 Redoxin K02199 - - 0.00000000000000000000000000000000000000000000000000000000002694 233.0
TLS2_k127_935489_4 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000006179 161.0
TLS2_k127_935489_5 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000001753 105.0
TLS2_k127_935584_0 IMP dehydrogenase / GMP reductase domain K22083 - 2.1.1.21 3.209e-227 724.0
TLS2_k127_935584_1 Glutamine synthetase, catalytic domain K01915,K01949 - 6.3.1.2,6.3.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009031 627.0
TLS2_k127_935584_2 Glutamine amidotransferase domain K22081 - 2.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 366.0
TLS2_k127_935584_3 GXGXG motif K22082 - 2.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 322.0
TLS2_k127_935584_4 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000003438 235.0
TLS2_k127_935584_5 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000002801 223.0
TLS2_k127_935584_6 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.000001545 57.0
TLS2_k127_935584_7 PFAM transposase IS116 IS110 IS902 family K07486 - - 0.00007118 52.0
TLS2_k127_93644_0 COG3666 Transposase and inactivated derivatives - - - 1.084e-232 726.0
TLS2_k127_938014_0 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.0 1619.0
TLS2_k127_938014_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 1.647e-291 904.0
TLS2_k127_938014_2 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 452.0
TLS2_k127_940817_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088,K00364 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205,1.7.1.7 2.554e-221 695.0
TLS2_k127_940817_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 2.19e-214 684.0
TLS2_k127_940817_2 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 438.0
TLS2_k127_940817_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 435.0
TLS2_k127_940817_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003057 389.0
TLS2_k127_940817_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002857 257.0
TLS2_k127_940817_6 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000007717 258.0
TLS2_k127_940817_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000001994 243.0
TLS2_k127_940817_8 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000003149 174.0
TLS2_k127_940817_9 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 0.0000000000000000000000003624 106.0
TLS2_k127_941143_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 8.552e-214 681.0
TLS2_k127_942164_0 Belongs to the HpcH HpaI aldolase family K08691 - 4.1.3.24,4.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 489.0
TLS2_k127_942164_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007164 413.0
TLS2_k127_942164_2 Belongs to the 'phage' integrase family. XerC subfamily K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 359.0
TLS2_k127_942164_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 306.0
TLS2_k127_942164_4 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000000000000000005279 204.0
TLS2_k127_942164_5 - - - - 0.0000000000000000000000000000000006787 149.0
TLS2_k127_942164_6 - - - - 0.00000001284 57.0
TLS2_k127_942297_0 COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 424.0
TLS2_k127_942297_1 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 345.0
TLS2_k127_942297_2 FR47-like protein - - - 0.00002021 52.0
TLS2_k127_946523_0 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 571.0
TLS2_k127_946523_1 PEP-utilising enzyme, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 471.0
TLS2_k127_946523_10 Protein of unknown function (DUF3305) - - - 0.0000000000000000000000000000000000000000001263 169.0
TLS2_k127_946523_11 Protein of unknown function (DUF3306) - - - 0.00000000000000000002115 99.0
TLS2_k127_946523_12 PTS HPr component phosphorylation site K11189 - - 0.0000000000000000002721 96.0
TLS2_k127_946523_2 Dak1 domain K05878 - 2.7.1.121 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 448.0
TLS2_k127_946523_3 Part of the ABC transporter complex NodIJ involved in the export of the nodulation factors (Nod factors), the bacterial signal molecules that induce symbiosis and subsequent nodulation induction. Nod factors are LCO (lipo-chitin oligosaccharide), a modified beta-1,4-linked N-acetylglucosamine oligosaccharide. This subunit is responsible for energy coupling to the transport system K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 312.0
TLS2_k127_946523_4 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 304.0
TLS2_k127_946523_5 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006849 244.0
TLS2_k127_946523_6 Dak2 K05879 - 2.7.1.121 0.0000000000000000000000000000000000000000000000000003921 191.0
TLS2_k127_946523_7 phosphoglycerate mutase - - - 0.0000000000000000000000000000000000000000000000001647 186.0
TLS2_k127_946523_8 PTS system fructose IIA component K05881 - 2.7.1.121 0.0000000000000000000000000000000000000000000000681 172.0
TLS2_k127_946523_9 TIGRFAM ABC-2 type transporter, NodJ K09694 - - 0.0000000000000000000000000000000000000000000004752 189.0
TLS2_k127_946686_0 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 1.351e-259 831.0
TLS2_k127_946686_1 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 1.555e-249 814.0
TLS2_k127_946686_2 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 8.177e-238 750.0
TLS2_k127_946686_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 447.0
TLS2_k127_946686_4 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007432 421.0
TLS2_k127_946686_5 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 317.0
TLS2_k127_946686_6 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000003023 240.0
TLS2_k127_946686_7 Threonylcarbamoyl adenosine biosynthesis protein TsaE K07102 - 2.7.1.221 0.0000000000000000000000000000194 134.0
TLS2_k127_946686_8 Phosphorylase superfamily K01243 - 3.2.2.9 0.0000000000001301 81.0
TLS2_k127_946686_9 Acetyltransferase (GNAT) domain - - - 0.0000001041 60.0
TLS2_k127_946721_0 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 5.172e-222 698.0
TLS2_k127_946721_1 DNA RNA helicase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009366 331.0
TLS2_k127_946721_2 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 313.0
TLS2_k127_946721_3 Domain of unknown function (DUF892) - - - 0.0000000000000000000000000000000000000000000000000000001965 211.0
TLS2_k127_946721_4 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000003591 196.0
TLS2_k127_946721_5 Helix-turn-helix domain - - - 0.00000000000001142 87.0
TLS2_k127_961717_0 Bacterial extracellular solute-binding protein K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 551.0
TLS2_k127_961717_1 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 350.0
TLS2_k127_961717_2 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 353.0
TLS2_k127_961717_3 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004043 286.0
TLS2_k127_961717_4 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001638 273.0
TLS2_k127_961717_5 amino acid K01995 - - 0.00000000000000000000000000000000000000000000000000000000000005408 235.0
TLS2_k127_961717_6 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000004549 225.0
TLS2_k127_961717_7 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052 - - 0.00000000000000000000000000000000007206 137.0
TLS2_k127_961717_9 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 GO:0003674,GO:0003824,GO:0003825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0006970,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016311,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034637,GO:0035251,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046527,GO:0050896,GO:0051716,GO:0070413,GO:0070415,GO:0070417,GO:0071704,GO:1901576 2.4.1.15,2.4.1.347 0.00000000000006027 73.0
TLS2_k127_965381_0 AMP-binding enzyme C-terminal domain K18661 - - 1.222e-203 645.0
TLS2_k127_965381_1 response regulator receiver K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 507.0
TLS2_k127_965381_10 Phasin protein - - - 0.00000000000000000000000002486 113.0
TLS2_k127_965381_11 Membrane fusogenic activity K09806 - - 0.000000000000000000238 94.0
TLS2_k127_965381_2 2-dehydropantoate 2-reductase K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 425.0
TLS2_k127_965381_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 357.0
TLS2_k127_965381_4 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 294.0
TLS2_k127_965381_5 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005277 268.0
TLS2_k127_965381_6 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000002181 167.0
TLS2_k127_965381_7 Putative tRNA binding domain K06878 - - 0.00000000000000000000000000000000000000000026 162.0
TLS2_k127_965381_8 Histidine kinase - - - 0.000000000000000000000000000000000000000002542 171.0
TLS2_k127_965381_9 transcriptional regulator - - - 0.0000000000000000000000000000001156 132.0
TLS2_k127_966233_0 homoserine kinase activity K02204 - 2.7.1.39 0.0 1257.0
TLS2_k127_966233_1 Glycogen debranching enzyme N terminal - - - 1.398e-247 780.0
TLS2_k127_966233_10 LTXXQ motif family protein - - - 0.00000000001683 72.0
TLS2_k127_966233_11 alcohol dehydrogenase K00043 - 1.1.1.61 0.00005007 50.0
TLS2_k127_966233_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 470.0
TLS2_k127_966233_3 COG1879 ABC-type sugar transport system periplasmic component K10439 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 450.0
TLS2_k127_966233_4 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008479 449.0
TLS2_k127_966233_5 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 423.0
TLS2_k127_966233_6 homoserine dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 407.0
TLS2_k127_966233_7 Enoyl-(Acyl carrier protein) reductase K00034 - 1.1.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009663 396.0
TLS2_k127_966233_8 Shikimate / quinate 5-dehydrogenase K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007475 374.0
TLS2_k127_966233_9 META domain - - - 0.00000000000000728 87.0
TLS2_k127_972395_0 Diguanylate cyclase - - - 3.313e-232 747.0
TLS2_k127_972395_1 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 465.0
TLS2_k127_972395_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000008938 211.0
TLS2_k127_972395_3 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000065 160.0
TLS2_k127_972395_4 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000007932 107.0
TLS2_k127_973148_0 COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 597.0
TLS2_k127_973148_1 Aminotransferase class-III K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 578.0
TLS2_k127_973148_10 Plasmid stability protein K21495 - - 0.00000000049 66.0
TLS2_k127_973148_2 Domain of unknown function (DUF4339) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 467.0
TLS2_k127_973148_3 Belongs to the TelA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 424.0
TLS2_k127_973148_4 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 400.0
TLS2_k127_973148_5 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 338.0
TLS2_k127_973148_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.000000000000000000000000000000000000000000000000000171 188.0
TLS2_k127_973148_7 PFAM 5-bromo-4-chloroindolyl phosphate hydrolysis protein - - - 0.00000000000000000000000000000000000007784 154.0
TLS2_k127_973148_8 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000003689 99.0
TLS2_k127_973148_9 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000005147 95.0
TLS2_k127_975555_0 ABC-type multidrug transport system, ATPase and permease K06147 - - 3.249e-224 724.0
TLS2_k127_975555_1 TRAP-type mannitol chloroaromatic compound transport system large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 520.0
TLS2_k127_975555_2 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 371.0
TLS2_k127_975555_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08351 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 361.0
TLS2_k127_975555_4 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000001224 209.0
TLS2_k127_975555_5 Ribosomal protein L31 K02909 - - 0.00000000000000000000000000003961 118.0
TLS2_k127_975555_6 Domain of unknown function DUF29 - - - 0.00000000000000000000003402 106.0
TLS2_k127_975555_7 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000000003226 75.0
TLS2_k127_980043_0 Peptidase family M20/M25/M40 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 581.0
TLS2_k127_980043_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 297.0
TLS2_k127_980043_2 Integral membrane protein (DUF2244) - - - 0.00000000000000000000000000000000000000000000002457 177.0
TLS2_k127_980043_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000007021 162.0
TLS2_k127_980043_4 Putative peptidoglycan binding domain - - - 0.0000001625 62.0
TLS2_k127_985973_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03941 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 312.0
TLS2_k127_985973_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004458 274.0
TLS2_k127_985973_2 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000303 249.0
TLS2_k127_985973_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.0000002121 63.0
TLS2_k127_988048_0 carbohydrate transport K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008236 604.0
TLS2_k127_988048_1 ATP synthase alpha/beta family, nucleotide-binding domain K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007893 509.0
TLS2_k127_988048_10 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 316.0
TLS2_k127_988048_11 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002207 267.0
TLS2_k127_988048_12 ChrR Cupin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003906 259.0
TLS2_k127_988048_13 Belongs to the sulfur carrier protein TusA family K04085 - - 0.0000000000000000000001896 98.0
TLS2_k127_988048_14 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.0000000000000001049 82.0
TLS2_k127_988048_2 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004196 471.0
TLS2_k127_988048_3 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 443.0
TLS2_k127_988048_4 Binding-protein-dependent transport system inner membrane component K10229 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 440.0
TLS2_k127_988048_5 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 416.0
TLS2_k127_988048_6 Transcriptional regulatory protein, C terminal K02483,K13584 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 372.0
TLS2_k127_988048_7 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 364.0
TLS2_k127_988048_8 PFAM ABC transporter related K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005547 336.0
TLS2_k127_988048_9 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 317.0
TLS2_k127_989264_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15785 - 2.6.1.76 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 539.0
TLS2_k127_989264_1 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 501.0
TLS2_k127_989264_2 Nitrite and sulphite reductase 4Fe-4S domain K00381,K00392 - 1.8.1.2,1.8.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 457.0
TLS2_k127_989264_3 guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002376 273.0
TLS2_k127_989264_4 SCO1/SenC K07152 - - 0.000000000000000000002518 108.0
TLS2_k127_989300_0 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001275 291.0
TLS2_k127_989300_1 Transcriptional regulator IclR - - - 0.0000000000000000000000000000000000000000000000000000000000000000006439 242.0
TLS2_k127_989300_2 Enoyl-CoA hydratase/isomerase K07536 - - 0.0000000000000000000000000000000000000000000000000000000000000002292 229.0
TLS2_k127_989300_3 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000000000002775 140.0
TLS2_k127_989986_0 COG0841 Cation multidrug efflux pump - - - 0.0 1546.0
TLS2_k127_989986_1 Barrel-sandwich domain of CusB or HlyD membrane-fusion K18901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 370.0
TLS2_k127_989986_2 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000837 250.0
TLS2_k127_989986_3 PFAM Transposase, IS4-like - - - 0.000000000000000000000001192 107.0
TLS2_k127_989986_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000003652 55.0