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Overview

ID MAG03987
Name TLS2_bin.18
Sample SMP0104
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Sphingomonadales
Family Sphingomonadaceae
Genus Sphingomicrobium
Species
Assembly information
Completeness (%) 81.84
Contamination (%) 1.94
GC content (%) 65.0
N50 (bp) 31,781
Genome size (bp) 1,907,494

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1920

Gene name Description KEGG GOs EC E-value Score Sequence
TLS2_k127_1048073_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1249.0
TLS2_k127_1048073_1 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0 1040.0
TLS2_k127_1048073_10 COG1228 Imidazolonepropionase and related amidohydrolases - - - 3.436e-211 662.0
TLS2_k127_1048073_11 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 2.115e-206 653.0
TLS2_k127_1048073_12 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 5.505e-195 625.0
TLS2_k127_1048073_13 FAD linked - - - 6.303e-195 617.0
TLS2_k127_1048073_14 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 548.0
TLS2_k127_1048073_15 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009106 502.0
TLS2_k127_1048073_16 enoyl-CoA hydratase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 513.0
TLS2_k127_1048073_17 Phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003329 503.0
TLS2_k127_1048073_18 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 493.0
TLS2_k127_1048073_19 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 453.0
TLS2_k127_1048073_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1029.0
TLS2_k127_1048073_20 of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 445.0
TLS2_k127_1048073_21 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 438.0
TLS2_k127_1048073_22 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 410.0
TLS2_k127_1048073_23 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 407.0
TLS2_k127_1048073_24 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 380.0
TLS2_k127_1048073_25 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004446 379.0
TLS2_k127_1048073_26 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 367.0
TLS2_k127_1048073_27 phosphoesterase, PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 368.0
TLS2_k127_1048073_28 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 367.0
TLS2_k127_1048073_29 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003886 354.0
TLS2_k127_1048073_3 Methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 3.185e-290 895.0
TLS2_k127_1048073_30 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 347.0
TLS2_k127_1048073_31 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006201 344.0
TLS2_k127_1048073_32 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008265 332.0
TLS2_k127_1048073_33 Forms part of the polypeptide exit tunnel K02926 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 334.0
TLS2_k127_1048073_34 Branched-chain amino acid aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 329.0
TLS2_k127_1048073_35 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000688 316.0
TLS2_k127_1048073_36 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 298.0
TLS2_k127_1048073_37 COG0694 Thioredoxin-like proteins and domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 287.0
TLS2_k127_1048073_38 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002548 278.0
TLS2_k127_1048073_39 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003992 274.0
TLS2_k127_1048073_4 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.493e-286 885.0
TLS2_k127_1048073_40 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001765 282.0
TLS2_k127_1048073_41 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008793 256.0
TLS2_k127_1048073_42 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006195 249.0
TLS2_k127_1048073_43 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009813 254.0
TLS2_k127_1048073_44 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003495 239.0
TLS2_k127_1048073_45 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000000000000002555 233.0
TLS2_k127_1048073_46 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000008685 223.0
TLS2_k127_1048073_47 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000005488 220.0
TLS2_k127_1048073_48 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000000000000000000000000001026 218.0
TLS2_k127_1048073_49 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000002104 209.0
TLS2_k127_1048073_5 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 2.669e-237 740.0
TLS2_k127_1048073_50 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000000000000000000000000000008357 211.0
TLS2_k127_1048073_51 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000000000002477 203.0
TLS2_k127_1048073_52 peptidase M22 - - - 0.000000000000000000000000000000000000000000000000000000007215 204.0
TLS2_k127_1048073_53 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000001644 199.0
TLS2_k127_1048073_54 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000000000000000000000003333 190.0
TLS2_k127_1048073_55 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000005351 178.0
TLS2_k127_1048073_56 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000000000000000000000000000001196 177.0
TLS2_k127_1048073_57 glyoxalase III activity - - - 0.0000000000000000000000000000000000000000000000006689 185.0
TLS2_k127_1048073_58 Acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000001237 173.0
TLS2_k127_1048073_59 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000000001451 173.0
TLS2_k127_1048073_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 2.354e-230 717.0
TLS2_k127_1048073_60 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000000000000000000000000000000246 166.0
TLS2_k127_1048073_61 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000004529 171.0
TLS2_k127_1048073_62 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000003425 161.0
TLS2_k127_1048073_63 - - - - 0.000000000000000000000000000000000000009099 150.0
TLS2_k127_1048073_64 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000004049 143.0
TLS2_k127_1048073_65 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000002261 143.0
TLS2_k127_1048073_66 Arginine repressor, DNA binding domain K03402 - - 0.000000000000000000000000000000000137 137.0
TLS2_k127_1048073_67 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000001996 136.0
TLS2_k127_1048073_68 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000005336 128.0
TLS2_k127_1048073_69 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.000000000000000000000000004366 117.0
TLS2_k127_1048073_7 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.281e-226 709.0
TLS2_k127_1048073_71 Pfam Secreted repeat of - - - 0.000000000000000000000284 102.0
TLS2_k127_1048073_72 Ribosomal protein L30 K02907 - - 0.00000000000000000000746 94.0
TLS2_k127_1048073_73 - - - - 0.00000000000000000002131 96.0
TLS2_k127_1048073_74 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000005342 90.0
TLS2_k127_1048073_75 - - - - 0.000000002573 64.0
TLS2_k127_1048073_76 - - - - 0.00000001793 61.0
TLS2_k127_1048073_79 - - - - 0.00003748 50.0
TLS2_k127_1048073_8 acyl-CoA dehydrogenase K00249 - 1.3.8.7 5.693e-217 679.0
TLS2_k127_1048073_80 - - - - 0.0007338 47.0
TLS2_k127_1048073_9 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.713e-216 675.0
TLS2_k127_1094125_0 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006465 400.0
TLS2_k127_1094125_1 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 385.0
TLS2_k127_1094125_10 arsenate reductase K00537 - 1.20.4.1 0.000000000000000000000000000000004692 134.0
TLS2_k127_1094125_11 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000000000000007554 130.0
TLS2_k127_1094125_12 COG0668 Small-conductance mechanosensitive channel - - - 0.00000000000000000000004013 99.0
TLS2_k127_1094125_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007636 320.0
TLS2_k127_1094125_3 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009767 285.0
TLS2_k127_1094125_4 Cold shock protein domain K03704 - - 0.00000000000000000000000000000000000000000000000000000000000006314 219.0
TLS2_k127_1094125_6 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.000000000000000000000000000000000000000000000004731 175.0
TLS2_k127_1094125_7 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000000000000000000009351 165.0
TLS2_k127_1094125_8 Regulatory protein RecX K03565 - - 0.0000000000000000000000000000000000000000001073 166.0
TLS2_k127_1094125_9 alpha beta - - - 0.0000000000000000000000000000000000000004928 157.0
TLS2_k127_1179483_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0 1152.0
TLS2_k127_1179483_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1083.0
TLS2_k127_1179483_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002315 257.0
TLS2_k127_1179483_11 Domain of unknown function (DUF4115) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005599 248.0
TLS2_k127_1179483_12 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000001454 248.0
TLS2_k127_1179483_13 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000006534 235.0
TLS2_k127_1179483_14 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000000005899 210.0
TLS2_k127_1179483_15 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000000000000000000005013 192.0
TLS2_k127_1179483_16 Membrane-bound metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000005967 202.0
TLS2_k127_1179483_17 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000134 190.0
TLS2_k127_1179483_18 Disulfide bond formation protein - - - 0.00000000000000000000000000000000000000000000000000344 186.0
TLS2_k127_1179483_19 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000000000000000251 168.0
TLS2_k127_1179483_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 3.504e-209 657.0
TLS2_k127_1179483_20 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000000000000002566 145.0
TLS2_k127_1179483_21 nuclease - - - 0.000000000000000000000000000000000001578 148.0
TLS2_k127_1179483_22 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000001048 127.0
TLS2_k127_1179483_23 PilZ domain - - - 0.00000000000000000000000000002032 126.0
TLS2_k127_1179483_24 - - - - 0.0000000000000000000000000007335 119.0
TLS2_k127_1179483_25 SnoaL-like domain - - - 0.00000000000000000000000001552 114.0
TLS2_k127_1179483_26 MltA-interacting protein MipA - - - 0.0000000000000001633 85.0
TLS2_k127_1179483_3 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 535.0
TLS2_k127_1179483_4 Sulfotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 406.0
TLS2_k127_1179483_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 323.0
TLS2_k127_1179483_6 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 317.0
TLS2_k127_1179483_7 beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005782 284.0
TLS2_k127_1179483_8 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008997 271.0
TLS2_k127_1179483_9 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000003811 272.0
TLS2_k127_1216573_0 Transposase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 516.0
TLS2_k127_1219737_0 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 1.014e-291 900.0
TLS2_k127_1219737_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 1.903e-209 662.0
TLS2_k127_1219737_10 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000002481 254.0
TLS2_k127_1219737_11 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000000000000000000000002635 239.0
TLS2_k127_1219737_12 methylmalonyl-CoA epimerase K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000001732 234.0
TLS2_k127_1219737_13 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000001547 185.0
TLS2_k127_1219737_14 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000002849 184.0
TLS2_k127_1219737_15 Protein of unknown function (DUF1622) - - - 0.00000000000000000000000000000007282 128.0
TLS2_k127_1219737_16 Belongs to the UPF0335 family - - - 0.00000000000000000000000000000008168 125.0
TLS2_k127_1219737_17 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000000001632 83.0
TLS2_k127_1219737_18 Resolvase - - - 0.000132 48.0
TLS2_k127_1219737_2 UDP-galactopyranose mutase K01854 - 5.4.99.9 3.866e-201 634.0
TLS2_k127_1219737_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 552.0
TLS2_k127_1219737_4 beta-glucosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 544.0
TLS2_k127_1219737_5 UDP-galactopyranose mutase K01854 - 5.4.99.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 487.0
TLS2_k127_1219737_6 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 385.0
TLS2_k127_1219737_7 Belongs to the glycosyl hydrolase 43 family K06113 - 3.2.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 388.0
TLS2_k127_1219737_8 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005976 366.0
TLS2_k127_1219737_9 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.00000000000000000000000000000000000000000000000000000000000000000000000001414 260.0
TLS2_k127_1245208_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 6.436e-222 696.0
TLS2_k127_1245208_1 5-aminolevulinic acid synthase K00643 - 2.3.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 389.0
TLS2_k127_1245208_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 329.0
TLS2_k127_1245208_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001011 265.0
TLS2_k127_1245208_4 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000001228 218.0
TLS2_k127_1245208_5 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000002626 216.0
TLS2_k127_1245208_6 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000001518 123.0
TLS2_k127_1252814_0 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.00000000000000000000000000000001165 138.0
TLS2_k127_1252814_1 Putative transposase of IS4/5 family (DUF4096) - - - 0.00000000000000003749 82.0
TLS2_k127_1252814_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000001231 82.0
TLS2_k127_1258558_0 Belongs to the transketolase family K00615 - 2.2.1.1 4.293e-319 989.0
TLS2_k127_1258558_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 7.929e-234 728.0
TLS2_k127_1258558_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 333.0
TLS2_k127_1258558_11 Cell Wall Hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 295.0
TLS2_k127_1258558_12 COG0739 Membrane proteins related to metalloendopeptidases K21472 - - 0.000000000000000000000000000000000000000000000000000000000000001458 224.0
TLS2_k127_1258558_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000002883 229.0
TLS2_k127_1258558_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000003356 198.0
TLS2_k127_1258558_15 5-formyltetrahydrofolate cyclo-ligase K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000001771 168.0
TLS2_k127_1258558_16 ATPase with chaperone activity K07391 - - 0.000000000000000000000000000000000000000000855 158.0
TLS2_k127_1258558_17 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000000000000003781 133.0
TLS2_k127_1258558_18 NADH dehydrogenase K00334 - 1.6.5.3 0.000000000000002133 84.0
TLS2_k127_1258558_19 Domain of unknown function (DUF4437) - - - 0.0000000000002477 76.0
TLS2_k127_1258558_2 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 1.173e-205 650.0
TLS2_k127_1258558_21 Prolyl 3-hydroxylase K08134,K19606,K22459,K22460 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008285,GO:0009058,GO:0009987,GO:0012505,GO:0016491,GO:0016705,GO:0016706,GO:0017185,GO:0018126,GO:0018193,GO:0018205,GO:0018208,GO:0019511,GO:0019538,GO:0019797,GO:0019798,GO:0031543,GO:0031544,GO:0032963,GO:0032964,GO:0032991,GO:0036211,GO:0042127,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051213,GO:0055114,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1902494 1.14.11.7 0.000000001071 71.0
TLS2_k127_1258558_22 DnaJ molecular chaperone homology domain - - - 0.00001485 55.0
TLS2_k127_1258558_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006457 593.0
TLS2_k127_1258558_4 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 509.0
TLS2_k127_1258558_5 Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007029 441.0
TLS2_k127_1258558_6 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 433.0
TLS2_k127_1258558_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 352.0
TLS2_k127_1258558_8 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 339.0
TLS2_k127_1258558_9 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 328.0
TLS2_k127_1365040_0 peptidase M13 K07386 - - 5.253e-315 979.0
TLS2_k127_1365040_1 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 7.104e-203 652.0
TLS2_k127_1365040_2 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 443.0
TLS2_k127_1365040_3 Histidine kinase K13587 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 342.0
TLS2_k127_1365040_4 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000000000000000004223 246.0
TLS2_k127_1365040_5 Histidine kinase K13587 - 2.7.13.3 0.00000000000000000000000000000000000000000000000002521 179.0
TLS2_k127_1365040_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000001876 178.0
TLS2_k127_1388038_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 434.0
TLS2_k127_1388038_1 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000002231 244.0
TLS2_k127_1414569_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009647 524.0
TLS2_k127_1414569_1 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007914 488.0
TLS2_k127_1414569_2 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002351 464.0
TLS2_k127_1414569_3 HWE histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 448.0
TLS2_k127_1414569_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008864 399.0
TLS2_k127_1414569_5 Protein of unknown function (DUF1465) K13592 - - 0.00000000000000000000000000000000000000000000000000000000000009401 217.0
TLS2_k127_1414569_6 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000002308 205.0
TLS2_k127_1414569_7 Belongs to the CinA family K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000202 154.0
TLS2_k127_1414569_8 Small protein - - - 0.0000000001513 63.0
TLS2_k127_1444094_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 2.375e-232 728.0
TLS2_k127_1444094_1 TrkA-C domain - - - 4.398e-201 640.0
TLS2_k127_1444094_2 Osmosensitive K channel K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 444.0
TLS2_k127_1444094_3 amino acid K03294,K03759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 437.0
TLS2_k127_1444094_4 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003112 277.0
TLS2_k127_1444094_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003629 273.0
TLS2_k127_1444094_6 COG1226 Kef-type K transport systems - - - 0.0000001865 59.0
TLS2_k127_1444094_7 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00001206 47.0
TLS2_k127_14530_0 Transport of potassium into the cell K03549 - - 9.456e-274 854.0
TLS2_k127_14530_1 2'-5' RNA ligase superfamily - - - 0.0000000000000000000000000000000000000002222 171.0
TLS2_k127_1536108_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1234.0
TLS2_k127_1536108_1 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 9.168e-275 855.0
TLS2_k127_1536108_10 protein conserved in bacteria - - - 0.00000000000000000006234 90.0
TLS2_k127_1536108_11 Domain of unknown function (DUF4402) - - - 0.000000000000000345 86.0
TLS2_k127_1536108_12 Putative prokaryotic signal transducing protein - - - 0.000000002187 66.0
TLS2_k127_1536108_2 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase K06147 - - 1.487e-251 786.0
TLS2_k127_1536108_3 peptidase U62, modulator of DNA gyrase K03568 - - 7.174e-237 739.0
TLS2_k127_1536108_4 ABC-type multidrug transport system, ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004417 466.0
TLS2_k127_1536108_5 beta' subunit K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000003123 265.0
TLS2_k127_1536108_6 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000007883 201.0
TLS2_k127_1536108_7 Copper amine oxidase - - - 0.0000000000000000000000000000000000000000002083 162.0
TLS2_k127_1536108_8 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000005607 154.0
TLS2_k127_1536108_9 Domain of unknown function (DUF4402) - - - 0.00000000000000000000001307 106.0
TLS2_k127_1657479_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.266e-272 844.0
TLS2_k127_1657479_1 Flp pilus assembly protein, ATPase CpaF K02283 - - 1.894e-267 829.0
TLS2_k127_1657479_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 396.0
TLS2_k127_1657479_3 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 353.0
TLS2_k127_1657479_4 response regulator K13589 - - 0.0000000000000000000000000000000000000000000000000000000000000001377 222.0
TLS2_k127_1657479_5 Uncharacterized conserved protein (DUF2267) - - - 0.0000000000000000000000000000000000000000000000000000000000007059 215.0
TLS2_k127_1657479_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 - - 0.000000000000000000000000003538 119.0
TLS2_k127_1657479_7 - - - - 0.0000000000000000000000008191 104.0
TLS2_k127_1657479_8 N-formylglutamate amidohydrolase - - - 0.000000000000000000002078 95.0
TLS2_k127_1663130_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1178.0
TLS2_k127_1663130_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1151.0
TLS2_k127_1663130_10 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 455.0
TLS2_k127_1663130_11 Chalcone and stilbene synthases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 442.0
TLS2_k127_1663130_12 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 444.0
TLS2_k127_1663130_13 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 384.0
TLS2_k127_1663130_14 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007475 384.0
TLS2_k127_1663130_15 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 379.0
TLS2_k127_1663130_16 C-terminal domain of 1-Cys peroxiredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 378.0
TLS2_k127_1663130_17 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 377.0
TLS2_k127_1663130_18 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 368.0
TLS2_k127_1663130_19 Dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 362.0
TLS2_k127_1663130_2 Participates in both transcription termination and antitermination K02600 - - 8.582e-275 856.0
TLS2_k127_1663130_20 metalloprotease K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005509 355.0
TLS2_k127_1663130_21 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 319.0
TLS2_k127_1663130_22 Nucleic-acid-binding protein K07742 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009967 265.0
TLS2_k127_1663130_23 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005306 250.0
TLS2_k127_1663130_24 Acetyltransferase (GNAT) domain K22479 - - 0.000000000000000000000000000000000000000000000000000000000000000000004605 242.0
TLS2_k127_1663130_25 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000000000000000000000000000000006642 223.0
TLS2_k127_1663130_26 Domain of unknown function (DUF4893) - - - 0.00000000000000000000000000000000000000000000000000000000000004222 222.0
TLS2_k127_1663130_27 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000000000000000000000000004006 212.0
TLS2_k127_1663130_28 Isoprenylcysteine carboxyl methyltransferase (ICMT) family K16168 - - 0.000000000000000000000000000000000000000000000000000000000009131 214.0
TLS2_k127_1663130_29 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000000003379 195.0
TLS2_k127_1663130_3 AbgT putative transporter family K12942 - - 8.957e-256 803.0
TLS2_k127_1663130_30 SBF-like CPA transporter family (DUF4137) K03453 - - 0.00000000000000000000000000000000000000000000000001377 193.0
TLS2_k127_1663130_31 Uncharacterized protein conserved in bacteria (DUF2171) - - - 0.000000000000000000000000000000000000000000000002636 189.0
TLS2_k127_1663130_32 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.000000000000000000000000000000000000002228 152.0
TLS2_k127_1663130_37 Belongs to the 'phage' integrase family - - - 0.00003865 49.0
TLS2_k127_1663130_38 signal transduction Histidine kinase K07640,K19609 - 2.7.13.3 0.00006142 47.0
TLS2_k127_1663130_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 3.171e-223 716.0
TLS2_k127_1663130_5 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 5.798e-208 659.0
TLS2_k127_1663130_6 amidohydrolase K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 608.0
TLS2_k127_1663130_7 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 495.0
TLS2_k127_1663130_8 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 519.0
TLS2_k127_1663130_9 alcohol dehydrogenase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 464.0
TLS2_k127_1890547_0 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 1.451e-288 889.0
TLS2_k127_1890547_1 synthetase K01897 - 6.2.1.3 1.833e-279 868.0
TLS2_k127_1890547_10 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000001747 265.0
TLS2_k127_1890547_11 ABC-type transport system involved in Fe-S cluster assembly, permease component K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001877 266.0
TLS2_k127_1890547_12 FeS assembly SUF system protein - - - 0.0000000000000000000000000000000000000000000000000000000009513 218.0
TLS2_k127_1890547_13 Belongs to the HesB IscA family K13628 - - 0.000000000000000000000000000000000000000000000000000000004085 205.0
TLS2_k127_1890547_14 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000007733 166.0
TLS2_k127_1890547_15 - - - - 0.000000000000000000000000000001148 124.0
TLS2_k127_1890547_2 protein conserved in bacteria - - - 6.72e-278 866.0
TLS2_k127_1890547_3 Subtilase family - - - 5.604e-260 822.0
TLS2_k127_1890547_4 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 7.505e-236 742.0
TLS2_k127_1890547_5 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 593.0
TLS2_k127_1890547_6 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 447.0
TLS2_k127_1890547_7 ABC-type transport system involved in Fe-S cluster assembly, ATPase component K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 387.0
TLS2_k127_1890547_8 Hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 325.0
TLS2_k127_1890547_9 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 298.0
TLS2_k127_1926015_0 Bacterial protein of unknown function (DUF853) K06915 - - 1.731e-212 670.0
TLS2_k127_1926015_1 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 595.0
TLS2_k127_1926015_2 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 289.0
TLS2_k127_1926015_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000008692 224.0
TLS2_k127_1926015_4 transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000003158 211.0
TLS2_k127_1926015_5 IV secretion system protein - - - 0.0000000005198 60.0
TLS2_k127_1951496_0 response regulator - - - 1.861e-240 754.0
TLS2_k127_1951496_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009684 579.0
TLS2_k127_1951496_10 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000001126 188.0
TLS2_k127_1951496_11 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000002704 128.0
TLS2_k127_1951496_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000646 572.0
TLS2_k127_1951496_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 470.0
TLS2_k127_1951496_4 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 461.0
TLS2_k127_1951496_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 423.0
TLS2_k127_1951496_6 Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2) K06127 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043334,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 377.0
TLS2_k127_1951496_7 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004704 317.0
TLS2_k127_1951496_8 import inner membrane translocase, subunit Tim44 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000281 269.0
TLS2_k127_1951496_9 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000000000000000000000000001515 207.0
TLS2_k127_2106477_0 N-carbamoylputrescine amidase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004894 493.0
TLS2_k127_2106477_1 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 481.0
TLS2_k127_2106477_2 peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 359.0
TLS2_k127_2130164_0 chemotaxis protein K03407 - 2.7.13.3 0.0 1080.0
TLS2_k127_2130164_1 Elongation factor G, domain IV K02355 - - 5.949e-286 892.0
TLS2_k127_2130164_10 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 427.0
TLS2_k127_2130164_11 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 422.0
TLS2_k127_2130164_12 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 420.0
TLS2_k127_2130164_13 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 397.0
TLS2_k127_2130164_14 PFAM polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 350.0
TLS2_k127_2130164_15 glycosyl transferase family 8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004694 340.0
TLS2_k127_2130164_16 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 335.0
TLS2_k127_2130164_17 SIS domain K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005122 321.0
TLS2_k127_2130164_18 Histidine phosphotransferase C-terminal domain K13588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002847 284.0
TLS2_k127_2130164_19 3-deoxy-manno-octulosonate cytidylyltransferase K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000001012 271.0
TLS2_k127_2130164_2 Histidine kinase K13587 - 2.7.13.3 2.715e-221 690.0
TLS2_k127_2130164_20 DnaJ molecular chaperone homology domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004914 259.0
TLS2_k127_2130164_21 hydrolase activity, acting on ester bonds K07017 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002206 258.0
TLS2_k127_2130164_22 Phage shock protein A K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001834 241.0
TLS2_k127_2130164_23 sugar phosphatases of the HAD superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000005601 249.0
TLS2_k127_2130164_24 cheY-homologous receiver domain K03413 - - 0.00000000000000000000000000000000000000000000000000000000000000000001863 233.0
TLS2_k127_2130164_25 COG1073 hydrolases of the alpha beta superfamily K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000002577 233.0
TLS2_k127_2130164_26 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000000000000000000000000000000001326 214.0
TLS2_k127_2130164_27 SufE protein probably involved in Fe-S center assembly K02426 - - 0.000000000000000000000000000000000000000000000000000000000513 204.0
TLS2_k127_2130164_28 Mitochondrial fission ELM1 K07276 - - 0.00000000000000000000000000000000000000000000000000433 200.0
TLS2_k127_2130164_29 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000000000000000002061 188.0
TLS2_k127_2130164_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 1.749e-197 625.0
TLS2_k127_2130164_30 PspC domain K03973 - - 0.0000000000000000000000000000000000000000001161 162.0
TLS2_k127_2130164_31 Mitochondrial fission ELM1 K07276 - - 0.000000000000000000000000000000000000000001155 179.0
TLS2_k127_2130164_32 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000008689 154.0
TLS2_k127_2130164_33 - - - - 0.000000000000000000000000000000001044 133.0
TLS2_k127_2130164_34 Phage shock protein B K03970 - - 0.00000000000000000000000004253 109.0
TLS2_k127_2130164_35 - - - - 0.0000000000000166 76.0
TLS2_k127_2130164_4 Sodium:dicarboxylate symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008516 546.0
TLS2_k127_2130164_5 RNA polymerase sigma K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 529.0
TLS2_k127_2130164_6 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 526.0
TLS2_k127_2130164_7 peptidase M20 K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004652 521.0
TLS2_k127_2130164_8 Major facilitator superfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 488.0
TLS2_k127_2130164_9 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002569 446.0
TLS2_k127_2146498_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.055e-221 700.0
TLS2_k127_2146498_1 ATPase with chaperone activity K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005417 483.0
TLS2_k127_2146498_2 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004905 425.0
TLS2_k127_2146498_3 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002757 325.0
TLS2_k127_2146498_4 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 313.0
TLS2_k127_2146498_5 conserved protein, contains double-stranded beta-helix domain - - - 0.000000000000000000000000000000000000000000000000000000009631 201.0
TLS2_k127_2146498_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000000000000000000000000000000000000002327 178.0
TLS2_k127_2146498_7 ATPase with chaperone activity K07391 - - 0.000000000000000000000000000000000000000000001397 168.0
TLS2_k127_2146498_8 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000000007608 130.0
TLS2_k127_2146498_9 - - - - 0.00000000000000000000000005918 111.0
TLS2_k127_2165041_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.162e-221 707.0
TLS2_k127_2165041_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003689 274.0
TLS2_k127_2165041_2 Peptidase M56 - - - 0.000000000000000000000000000000000000000000000000000003189 198.0
TLS2_k127_2236114_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1587.0
TLS2_k127_2236114_1 Histidine K01745 - 4.3.1.3 4.67e-216 681.0
TLS2_k127_2236114_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 9.548e-210 659.0
TLS2_k127_2236114_3 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 552.0
TLS2_k127_2236114_4 protein conserved in bacteria K09781 - - 0.000000000000000000000000000000000000000000000000000000000000005243 221.0
TLS2_k127_2236114_5 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000001231 219.0
TLS2_k127_2236114_6 SOS response K14160 - - 0.000000000000000000000000000000000000000000001616 173.0
TLS2_k127_2236114_7 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.000000000000000000000001963 110.0
TLS2_k127_2236114_8 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000003433 86.0
TLS2_k127_2363259_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1449.0
TLS2_k127_2363259_1 Helicase K03722 - 3.6.4.12 0.0 1266.0
TLS2_k127_2363259_10 Domain of unknown function (DUF305) - - - 0.0 1067.0
TLS2_k127_2363259_100 PilZ domain - - - 0.0007477 48.0
TLS2_k127_2363259_11 acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 2.311e-306 951.0
TLS2_k127_2363259_12 protein conserved in bacteria - - - 1.389e-301 934.0
TLS2_k127_2363259_13 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 7.073e-273 846.0
TLS2_k127_2363259_14 amino acid K03294 - - 1.141e-246 771.0
TLS2_k127_2363259_15 Glycosyl hydrolase family 1 - - - 1.024e-242 753.0
TLS2_k127_2363259_16 alanine symporter K03310 - - 3.351e-229 720.0
TLS2_k127_2363259_17 phosphomannomutase K01840 - 5.4.2.8 7.476e-227 709.0
TLS2_k127_2363259_18 mandelate racemase muconate lactonizing K01684,K01781,K08323 - 4.2.1.6,4.2.1.8,5.1.2.2 6.902e-210 656.0
TLS2_k127_2363259_19 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 4.958e-207 649.0
TLS2_k127_2363259_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1243.0
TLS2_k127_2363259_20 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 5.66e-206 650.0
TLS2_k127_2363259_21 Acts as a magnesium transporter K06213 - - 1.042e-200 635.0
TLS2_k127_2363259_22 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 601.0
TLS2_k127_2363259_23 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 593.0
TLS2_k127_2363259_24 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 578.0
TLS2_k127_2363259_25 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K08295 - 6.2.1.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 575.0
TLS2_k127_2363259_26 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 569.0
TLS2_k127_2363259_27 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 553.0
TLS2_k127_2363259_28 receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 554.0
TLS2_k127_2363259_29 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 520.0
TLS2_k127_2363259_3 Malic enzyme K00029 - 1.1.1.40 0.0 1224.0
TLS2_k127_2363259_30 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006974 526.0
TLS2_k127_2363259_31 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 509.0
TLS2_k127_2363259_32 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 506.0
TLS2_k127_2363259_33 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 497.0
TLS2_k127_2363259_34 Protein of unknown function (DUF3089) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 498.0
TLS2_k127_2363259_35 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 467.0
TLS2_k127_2363259_36 Major Facilitator K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007679 457.0
TLS2_k127_2363259_37 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 453.0
TLS2_k127_2363259_38 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 444.0
TLS2_k127_2363259_39 Galactose 1-dehydrogenase K00035 - 1.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 421.0
TLS2_k127_2363259_4 helicase K03724 - - 0.0 1211.0
TLS2_k127_2363259_40 Involved in the TonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 415.0
TLS2_k127_2363259_41 Aldose 1-epimerase K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 401.0
TLS2_k127_2363259_42 involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 389.0
TLS2_k127_2363259_43 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 396.0
TLS2_k127_2363259_44 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009658 381.0
TLS2_k127_2363259_45 Gluconolactonase K14274 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 364.0
TLS2_k127_2363259_46 ICC-like phosphoesterases K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009538 355.0
TLS2_k127_2363259_47 Aminomethyltransferase K06980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 349.0
TLS2_k127_2363259_48 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 332.0
TLS2_k127_2363259_49 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 332.0
TLS2_k127_2363259_5 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 0.0 1197.0
TLS2_k127_2363259_50 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 317.0
TLS2_k127_2363259_51 CarD family transcriptional regulator K07736 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 312.0
TLS2_k127_2363259_52 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 316.0
TLS2_k127_2363259_53 KR domain K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006077 305.0
TLS2_k127_2363259_54 Peptidase family S41 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 306.0
TLS2_k127_2363259_55 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 308.0
TLS2_k127_2363259_56 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 294.0
TLS2_k127_2363259_57 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000237 297.0
TLS2_k127_2363259_58 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004838 275.0
TLS2_k127_2363259_59 Aldolase K01631 - 4.1.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000005129 266.0
TLS2_k127_2363259_6 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0 1178.0
TLS2_k127_2363259_60 protein conserved in bacteria K09985 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000356 258.0
TLS2_k127_2363259_61 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000002376 254.0
TLS2_k127_2363259_62 Protein of unknown function (DUF2585) - - - 0.00000000000000000000000000000000000000000000000000000000000000000004169 238.0
TLS2_k127_2363259_63 - - - - 0.00000000000000000000000000000000000000000000000000000000000000001379 230.0
TLS2_k127_2363259_64 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000006689 215.0
TLS2_k127_2363259_65 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000001058 217.0
TLS2_k127_2363259_66 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000000000000000000000000000000000000000000000343 215.0
TLS2_k127_2363259_67 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000007258 208.0
TLS2_k127_2363259_68 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000000000000000000000000000000000000000000000002413 202.0
TLS2_k127_2363259_69 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000002075 195.0
TLS2_k127_2363259_7 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1164.0
TLS2_k127_2363259_70 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 GO:0005575,GO:0005576 1.3.3.11 0.0000000000000000000000000000000000000000000000000000003681 200.0
TLS2_k127_2363259_71 thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000000218 202.0
TLS2_k127_2363259_72 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000245 193.0
TLS2_k127_2363259_73 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000001245 198.0
TLS2_k127_2363259_74 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000008242 186.0
TLS2_k127_2363259_75 AsnC-type helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000007276 183.0
TLS2_k127_2363259_76 - - - - 0.000000000000000000000000000000000000000000000001271 178.0
TLS2_k127_2363259_77 Protein of unknown function (DUF1489) - - - 0.000000000000000000000000000000000000000000000008557 175.0
TLS2_k127_2363259_78 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000000000000000000008899 171.0
TLS2_k127_2363259_79 energy transducer activity - - - 0.0000000000000000000000000000000000000000000001888 179.0
TLS2_k127_2363259_8 Belongs to the AAA ATPase family K13525 - - 0.0 1133.0
TLS2_k127_2363259_80 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000002747 171.0
TLS2_k127_2363259_81 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000002261 162.0
TLS2_k127_2363259_82 Natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000001588 162.0
TLS2_k127_2363259_83 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000006654 160.0
TLS2_k127_2363259_84 FOG TPR repeat, SEL1 subfamily K07126 - - 0.000000000000000000000000000000000000001574 155.0
TLS2_k127_2363259_85 transcriptional - - - 0.0000000000000000000000000000000005255 136.0
TLS2_k127_2363259_86 Nickel/cobalt transporter regulator - - - 0.000000000000000000000000000000002732 138.0
TLS2_k127_2363259_87 Putative auto-transporter adhesin, head GIN domain - - - 0.00000000000000000000000000000004701 135.0
TLS2_k127_2363259_88 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000000005299 119.0
TLS2_k127_2363259_9 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1072.0
TLS2_k127_2363259_90 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.00000000000000000000000003453 114.0
TLS2_k127_2363259_91 Belongs to the ompA family K03640 - - 0.0000000000000000000000001314 115.0
TLS2_k127_2363259_92 component I K01665,K03342 - 2.6.1.85,4.1.3.38 0.00000000000000000000001129 102.0
TLS2_k127_2363259_93 Protein of unknwon function (DUF3008) - - - 0.000000000000000000009566 95.0
TLS2_k127_2363259_94 - - - - 0.00000000000000000007686 94.0
TLS2_k127_2363259_95 Lysozyme inhibitor LprI - - - 0.000000000000000514 89.0
TLS2_k127_2363259_96 KTSC domain - - - 0.00000000000007322 73.0
TLS2_k127_2363259_97 - - - - 0.0000000000004929 73.0
TLS2_k127_2497210_0 DNA recombination protein K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 512.0
TLS2_k127_2497210_1 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 387.0
TLS2_k127_2497210_2 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 363.0
TLS2_k127_2497210_3 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000000000003453 215.0
TLS2_k127_2497210_4 Ferredoxin - - - 0.0000000000000000000000000000000000000000000001972 184.0
TLS2_k127_2497210_5 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.00000000000000000000000001162 115.0
TLS2_k127_2497210_6 META domain - - - 0.0000000000000000000004577 101.0
TLS2_k127_2497210_7 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000001664 94.0
TLS2_k127_2497210_8 META domain K03668 - - 0.0001013 51.0
TLS2_k127_2512486_0 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 345.0
TLS2_k127_265840_0 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01469 - 3.5.2.9 0.0 1653.0
TLS2_k127_265840_1 Belongs to the thiolase family - - - 3.249e-195 614.0
TLS2_k127_265840_10 - - - - 0.000000000000000000000000000000000000000009273 158.0
TLS2_k127_265840_11 Protein of unknown function (DUF4239) - - - 0.00000000000000000000000000000002105 136.0
TLS2_k127_265840_12 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000002998 121.0
TLS2_k127_265840_2 4-hydroxyphenylpyruvate dioxygenase K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006955 555.0
TLS2_k127_265840_3 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 415.0
TLS2_k127_265840_4 Protein of unknown function (DUF2891) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 409.0
TLS2_k127_265840_5 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 302.0
TLS2_k127_265840_6 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006476 273.0
TLS2_k127_265840_7 COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001282 239.0
TLS2_k127_265840_8 Iron-sulfur cluster assembly protein K02612 - - 0.0000000000000000000000000000000000000000000000000000000000007143 213.0
TLS2_k127_265840_9 protein conserved in bacteria K09781 - - 0.000000000000000000000000000000000000000000002221 169.0
TLS2_k127_2925386_0 DNA polymerase K02337 - 2.7.7.7 0.0 1363.0
TLS2_k127_2925386_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K20034 - 6.2.1.44 1.069e-252 796.0
TLS2_k127_2925386_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 419.0
TLS2_k127_2925386_3 lipopolysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 298.0
TLS2_k127_2925386_4 - - - - 0.000000000000000000004283 96.0
TLS2_k127_2936389_0 Domain of unknown function (DUF4157) - - - 0.000000000000000000000000000005109 138.0
TLS2_k127_2936389_1 Domain of unknown function (DUF4157) - - - 0.00000002743 67.0
TLS2_k127_3024273_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1371.0
TLS2_k127_3024273_1 Domain related to MnhB subunit of Na+/H+ antiporter K05559 - - 0.0 1261.0
TLS2_k127_3024273_10 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 533.0
TLS2_k127_3024273_11 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003976 531.0
TLS2_k127_3024273_12 arginine N-succinyltransferase K00673 - 2.3.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 506.0
TLS2_k127_3024273_13 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 442.0
TLS2_k127_3024273_14 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 360.0
TLS2_k127_3024273_15 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 330.0
TLS2_k127_3024273_16 Diacylglycerol kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007529 328.0
TLS2_k127_3024273_17 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 311.0
TLS2_k127_3024273_18 Cupin superfamily (DUF985) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009215 255.0
TLS2_k127_3024273_19 Na+/H+ ion antiporter subunit K05562 - - 0.0000000000000000000000000000000000000000000000000000000000000003638 225.0
TLS2_k127_3024273_2 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0 1016.0
TLS2_k127_3024273_20 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000001398 217.0
TLS2_k127_3024273_21 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000003179 214.0
TLS2_k127_3024273_22 Universal stress protein - - - 0.000000000000000000000000000000000000000000000000000000000005809 213.0
TLS2_k127_3024273_23 SCO1/SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000008524 202.0
TLS2_k127_3024273_24 Thioesterase superfamily K10806 - - 0.0000000000000000000000000000000000000000000000000002526 187.0
TLS2_k127_3024273_25 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05560 - - 0.00000000000000000000000000000000000000000000001103 173.0
TLS2_k127_3024273_26 COG1320 Multisubunit Na H antiporter, MnhG subunit K05564 - - 0.00000000000000000000000000000000000000000000002149 179.0
TLS2_k127_3024273_27 Protein of unknown function (DUF1176) - - - 0.000000000000000000000000000000000000009931 158.0
TLS2_k127_3024273_28 Ion channel - - - 0.0000000000000000000000000000001525 128.0
TLS2_k127_3024273_29 Transcriptional - - - 0.0000000000000000000000000000002585 126.0
TLS2_k127_3024273_3 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 - 1.2.1.71 1.917e-231 724.0
TLS2_k127_3024273_30 COG2212 Multisubunit Na H antiporter, MnhF subunit K05563 - - 0.0000000000000000000000000003768 123.0
TLS2_k127_3024273_31 Protein conserved in bacteria K09796 - - 0.00000000000000000000000008409 112.0
TLS2_k127_3024273_32 - - - - 0.000000000000000000001113 100.0
TLS2_k127_3024273_33 - - - - 0.000000000000000000005338 98.0
TLS2_k127_3024273_34 - - - - 0.0000000000000000004699 91.0
TLS2_k127_3024273_35 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.000000001683 61.0
TLS2_k127_3024273_38 - - - - 0.00000737 56.0
TLS2_k127_3024273_4 Proton-conducting membrane transporter K05561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 610.0
TLS2_k127_3024273_5 Uncharacterized ACR, YdiU/UPF0061 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 606.0
TLS2_k127_3024273_6 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) K01484 - 3.5.3.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 596.0
TLS2_k127_3024273_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 580.0
TLS2_k127_3024273_8 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 576.0
TLS2_k127_3024273_9 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 542.0
TLS2_k127_3082852_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.065e-299 924.0
TLS2_k127_3082852_1 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 6.526e-247 766.0
TLS2_k127_3082852_10 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 362.0
TLS2_k127_3082852_11 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006298 348.0
TLS2_k127_3082852_12 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002573 289.0
TLS2_k127_3082852_13 membrane-associated protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003425 280.0
TLS2_k127_3082852_14 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007843 263.0
TLS2_k127_3082852_15 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000893 250.0
TLS2_k127_3082852_16 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000004132 237.0
TLS2_k127_3082852_17 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000007427 244.0
TLS2_k127_3082852_18 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002371 259.0
TLS2_k127_3082852_19 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001024 238.0
TLS2_k127_3082852_2 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 6.564e-220 691.0
TLS2_k127_3082852_20 metal-binding integral membrane protein - - - 0.000000000000000000000000000000000000000000000000008059 190.0
TLS2_k127_3082852_21 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000005713 182.0
TLS2_k127_3082852_22 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000003838 174.0
TLS2_k127_3082852_23 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000004668 178.0
TLS2_k127_3082852_24 PFAM Sterol-binding domain protein - - - 0.0000000000000000000000000000000000000000004542 159.0
TLS2_k127_3082852_25 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000000000000000000007931 158.0
TLS2_k127_3082852_26 CHRD domain - - - 0.000000000000000000000000000000000007515 142.0
TLS2_k127_3082852_27 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000001185 93.0
TLS2_k127_3082852_29 Domain of unknown function (DUF5076) - - - 0.0000002358 59.0
TLS2_k127_3082852_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 570.0
TLS2_k127_3082852_4 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 512.0
TLS2_k127_3082852_5 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 455.0
TLS2_k127_3082852_6 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 423.0
TLS2_k127_3082852_7 Belongs to the 'phage' integrase family K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 389.0
TLS2_k127_3082852_8 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003543 388.0
TLS2_k127_3082852_9 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 371.0
TLS2_k127_3107407_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0000049,GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005524,GO:0008144,GO:0016597,GO:0017076,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0046983,GO:0070905,GO:0097159,GO:0097367,GO:1901265,GO:1901363 6.1.1.11 0.0001199 44.0
TLS2_k127_3108056_0 - - - - 0.000000000000000000000000000000000000000000000000000002765 211.0
TLS2_k127_3108056_1 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000005802 143.0
TLS2_k127_3108056_2 Tetratricopeptide repeat - - - 0.000000000000000006407 91.0
TLS2_k127_3171054_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.3e-322 997.0
TLS2_k127_3171054_1 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 5.019e-295 923.0
TLS2_k127_3171054_10 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002664 593.0
TLS2_k127_3171054_11 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 600.0
TLS2_k127_3171054_12 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008816 586.0
TLS2_k127_3171054_13 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 581.0
TLS2_k127_3171054_14 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 560.0
TLS2_k127_3171054_15 NAD(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 532.0
TLS2_k127_3171054_16 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 531.0
TLS2_k127_3171054_17 Aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 441.0
TLS2_k127_3171054_18 dihydropteroate synthase K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 441.0
TLS2_k127_3171054_19 L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 396.0
TLS2_k127_3171054_2 amino acid peptide transporter K03305 - - 6.093e-248 777.0
TLS2_k127_3171054_20 LuxR family transcriptional regulator K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007747 394.0
TLS2_k127_3171054_21 Lytic murein transglycosylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 391.0
TLS2_k127_3171054_22 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 382.0
TLS2_k127_3171054_23 DNA polymerase K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 367.0
TLS2_k127_3171054_24 CHASE2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007916 360.0
TLS2_k127_3171054_26 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 327.0
TLS2_k127_3171054_27 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 316.0
TLS2_k127_3171054_28 MazG family K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 310.0
TLS2_k127_3171054_29 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 304.0
TLS2_k127_3171054_3 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 1.218e-240 751.0
TLS2_k127_3171054_30 aspartate racemase K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006803 313.0
TLS2_k127_3171054_31 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000566 304.0
TLS2_k127_3171054_32 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 286.0
TLS2_k127_3171054_33 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K07313 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 286.0
TLS2_k127_3171054_34 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007288 273.0
TLS2_k127_3171054_35 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003056 274.0
TLS2_k127_3171054_36 polysaccharide export K01991 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002715 265.0
TLS2_k127_3171054_37 nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000005436 221.0
TLS2_k127_3171054_38 NnrU protein - - - 0.00000000000000000000000000000000000000000000000000000000000001276 232.0
TLS2_k127_3171054_39 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000000000000000000000000000000000000000001319 222.0
TLS2_k127_3171054_4 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.169e-236 742.0
TLS2_k127_3171054_40 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000000000003698 216.0
TLS2_k127_3171054_41 Prolyl-tRNA synthetase - - - 0.000000000000000000000000000000000000000000000000000000001925 206.0
TLS2_k127_3171054_42 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000000000000000000006034 193.0
TLS2_k127_3171054_43 protein affecting Mg2 Co2 transport K06195 - - 0.0000000000000000000000000000000000000000000000000008245 187.0
TLS2_k127_3171054_44 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000319 182.0
TLS2_k127_3171054_45 Transcriptional regulator K07979 - - 0.00000000000000000000000000000000000000000000000003285 181.0
TLS2_k127_3171054_46 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000002404 171.0
TLS2_k127_3171054_47 nad(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000001358 164.0
TLS2_k127_3171054_49 Resolvase, N terminal domain - - - 0.0000000000385 65.0
TLS2_k127_3171054_5 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K13599 - - 2.373e-234 731.0
TLS2_k127_3171054_6 amidohydrolase - - - 2.299e-226 708.0
TLS2_k127_3171054_7 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 4.147e-219 688.0
TLS2_k127_3171054_8 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 1.952e-209 666.0
TLS2_k127_3171054_9 Putative diguanylate phosphodiesterase - - - 3.87e-204 659.0
TLS2_k127_3218676_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.536e-316 979.0
TLS2_k127_3218676_1 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 308.0
TLS2_k127_3218676_2 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000000000000000000003922 193.0
TLS2_k127_3218676_3 - - - - 0.0000000000000000000000000000000000000000000000001281 181.0
TLS2_k127_3218676_4 - K03832 - - 0.000000000000000000000000000000000000000000006237 172.0
TLS2_k127_3218676_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000001584 89.0
TLS2_k127_3218676_6 PspC domain protein - - - 0.000000000007516 77.0
TLS2_k127_3218676_7 Cold shock protein domain K03704 - - 0.0001765 46.0
TLS2_k127_3218676_8 Protein of unknown function (DUF2892) - - - 0.00036 52.0
TLS2_k127_3219729_0 Belongs to the UPF0262 family - - - 0.0000000000000000000000000000000000000000000000000000000000000003231 224.0
TLS2_k127_3219729_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000005642 153.0
TLS2_k127_3219729_2 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000001267 84.0
TLS2_k127_3219729_3 META domain - - - 0.0000103 53.0
TLS2_k127_324602_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 4.93e-226 710.0
TLS2_k127_324602_1 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 595.0
TLS2_k127_324602_10 Pilus assembly protein CpaD K02281 - - 0.00000000000000000000000000000000000000000000001479 177.0
TLS2_k127_324602_11 peptidase K02278 - 3.4.23.43 0.0000000000000000000000000000000000000000004452 165.0
TLS2_k127_324602_12 MAPEG family - - - 0.00000000000000000000000000000000001348 139.0
TLS2_k127_324602_13 Glycine dehydrogenase (aminomethyl-transferring) K00283 - 1.4.4.2 0.00000000002625 72.0
TLS2_k127_324602_2 Glycine cleavage system T protein K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 517.0
TLS2_k127_324602_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 485.0
TLS2_k127_324602_4 Oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 411.0
TLS2_k127_324602_5 Pilus assembly protein CpaB K02279 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 375.0
TLS2_k127_324602_6 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 321.0
TLS2_k127_324602_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007541 261.0
TLS2_k127_324602_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000001309 243.0
TLS2_k127_324602_9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000000000000000000002623 213.0
TLS2_k127_3266932_0 COG3436 Transposase and inactivated derivatives - - - 2.77e-243 760.0
TLS2_k127_3266932_1 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000454 209.0
TLS2_k127_3266932_2 IS66 Orf2 like protein K07484 - - 0.000000000000000000000000000000000000000000000000000002254 192.0
TLS2_k127_3287196_0 PAS fold K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004932 546.0
TLS2_k127_3287196_1 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000009183 232.0
TLS2_k127_3287196_2 Transposase K07481,K07487 - - 0.000000000002177 68.0
TLS2_k127_3312081_0 Belongs to the ClpA ClpB family K03694,K03695 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 570.0
TLS2_k127_3312081_1 PFAM heat shock protein DnaJ domain protein K03686,K05516 - - 0.0000000000000000000000000000000000000000000000003259 183.0
TLS2_k127_3371012_0 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004972 469.0
TLS2_k127_345464_0 NMT1-like family K15576,K22067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 393.0
TLS2_k127_345464_1 ANTAR K07183 - - 0.000000000000000000000000000000000000000000000000000000000000000103 238.0
TLS2_k127_345464_2 Cold shock K03704 - - 0.00000000000000000000000000158 113.0
TLS2_k127_353334_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001133 282.0
TLS2_k127_353334_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000005937 204.0
TLS2_k127_353334_3 Lytic murein transglycosylase - - - 0.00000000000000007564 86.0
TLS2_k127_361911_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 506.0
TLS2_k127_361911_1 Domain of unknown function (DUF3576) - - - 0.0000000000000000000000000000000000000000000000000000000001911 206.0
TLS2_k127_3625095_0 DNA ligase K01971 - 6.5.1.1 0.0 1130.0
TLS2_k127_3625095_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.942e-316 980.0
TLS2_k127_3625095_10 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 466.0
TLS2_k127_3625095_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 410.0
TLS2_k127_3625095_12 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 404.0
TLS2_k127_3625095_13 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005605 400.0
TLS2_k127_3625095_14 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 400.0
TLS2_k127_3625095_15 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 396.0
TLS2_k127_3625095_16 Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 378.0
TLS2_k127_3625095_17 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 374.0
TLS2_k127_3625095_18 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007613 372.0
TLS2_k127_3625095_19 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009376 375.0
TLS2_k127_3625095_2 COG2366 Protein related to penicillin acylase - - - 6.255e-313 976.0
TLS2_k127_3625095_20 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 368.0
TLS2_k127_3625095_21 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005537 294.0
TLS2_k127_3625095_22 Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 282.0
TLS2_k127_3625095_23 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003983 284.0
TLS2_k127_3625095_24 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000438 267.0
TLS2_k127_3625095_25 CoA binding domain K06929 - - 0.000000000000000000000000000000000000000000000000000000000000000001111 233.0
TLS2_k127_3625095_26 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000000000000004366 197.0
TLS2_k127_3625095_27 DoxX K15977 - - 0.00000000000000000000000000000000000000000000000000004398 190.0
TLS2_k127_3625095_28 Protein of unknown function (DUF3035) - - - 0.00000000000000000000000000000000000007935 146.0
TLS2_k127_3625095_3 of ABC transporters with duplicated ATPase K15738 - - 1.268e-283 881.0
TLS2_k127_3625095_30 ETC complex I subunit - - - 0.0000000000000000000000000000000006291 132.0
TLS2_k127_3625095_31 - - - - 0.00000000000000000000000000319 117.0
TLS2_k127_3625095_32 response regulator K02282,K07782,K19135 - - 0.00000000000000000000000001944 115.0
TLS2_k127_3625095_33 - - - - 0.00000000000000000002881 99.0
TLS2_k127_3625095_34 - - - - 0.000000000000000000104 94.0
TLS2_k127_3625095_35 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000000000001992 79.0
TLS2_k127_3625095_36 - - - - 0.000002213 55.0
TLS2_k127_3625095_37 Pilus assembly protein PilZ - - - 0.00000274 55.0
TLS2_k127_3625095_38 SnoaL-like domain - - - 0.000007097 54.0
TLS2_k127_3625095_4 glutamate--cysteine ligase K01919 - 6.3.2.2 3.861e-243 756.0
TLS2_k127_3625095_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 1.359e-216 685.0
TLS2_k127_3625095_6 Histidine kinase - - - 2.491e-200 637.0
TLS2_k127_3625095_7 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 522.0
TLS2_k127_3625095_8 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 500.0
TLS2_k127_3625095_9 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 494.0
TLS2_k127_3647889_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 459.0
TLS2_k127_3647889_1 protein conserved in bacteria K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 435.0
TLS2_k127_3647889_2 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 390.0
TLS2_k127_3647889_3 peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 364.0
TLS2_k127_3647889_4 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 309.0
TLS2_k127_3647889_5 Peroxiredoxin - - - 0.000000000000000000000000000000000000000000000000000000000000006167 224.0
TLS2_k127_3647889_6 response to hydrogen peroxide - - - 0.000000000000000000000000000000000000001094 154.0
TLS2_k127_3647889_7 - - - - 0.000000000000000000000000000000001572 132.0
TLS2_k127_3647889_9 positive regulation of macromolecule biosynthetic process K03973 - - 0.0000000000001196 72.0
TLS2_k127_3696934_0 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 445.0
TLS2_k127_3696934_1 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 418.0
TLS2_k127_3696934_2 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000001562 236.0
TLS2_k127_3696934_3 Prokaryotic cytochrome b561 K12262 - - 0.00000000000000000000000000000000000000000000000000000000000747 215.0
TLS2_k127_3696934_4 Winged helix DNA-binding domain - - - 0.00009255 51.0
TLS2_k127_3743188_0 Acyl-CoA hydrolase K10806 - - 0.00000000000000000000000000000000000000000000000000001043 196.0
TLS2_k127_3743188_1 CBS domain - - - 0.00000000000000000000000000000000000000000001576 166.0
TLS2_k127_3743188_2 Domain of unknown function (DUF4167) - - - 0.000000000000000000000000000000000000005265 152.0
TLS2_k127_3743188_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000005813 115.0
TLS2_k127_3743188_4 - - - - 0.00000000000002883 79.0
TLS2_k127_3743641_0 peptidase S9 K01354 - 3.4.21.83 2.5e-323 1014.0
TLS2_k127_3743641_1 aminopeptidase K01262 - 3.4.11.9 3.139e-292 906.0
TLS2_k127_3743641_2 Aldolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 441.0
TLS2_k127_3743641_3 Dehydrogenase K00101 - 1.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 290.0
TLS2_k127_3743641_4 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003556 278.0
TLS2_k127_3743641_5 thioesterase K07107 - - 0.00000000000000000000000000000000000000000000000000003429 204.0
TLS2_k127_3763086_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 582.0
TLS2_k127_3763086_1 Sugar-transfer associated ATP-grasp - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 314.0
TLS2_k127_3763086_2 peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.00000000000000000000000000000000000000000000000000029 192.0
TLS2_k127_3763086_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000377 49.0
TLS2_k127_3767113_0 Amidohydrolase family - - - 0.0 1508.0
TLS2_k127_3767113_1 protein conserved in bacteria K09800 - - 0.0 1445.0
TLS2_k127_3767113_10 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 600.0
TLS2_k127_3767113_11 Tryptophan halogenase K14266 - 1.14.19.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 548.0
TLS2_k127_3767113_12 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 505.0
TLS2_k127_3767113_13 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004032 493.0
TLS2_k127_3767113_14 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 483.0
TLS2_k127_3767113_15 cystathionine beta-lyase K01760 - 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 487.0
TLS2_k127_3767113_16 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 481.0
TLS2_k127_3767113_17 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 420.0
TLS2_k127_3767113_18 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 405.0
TLS2_k127_3767113_19 Hemolysin K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 386.0
TLS2_k127_3767113_2 Belongs to the heme-copper respiratory oxidase family K15408 - 1.9.3.1 0.0 1226.0
TLS2_k127_3767113_20 Belongs to the glutaminase family K01425 - 3.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009659 365.0
TLS2_k127_3767113_21 Nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 347.0
TLS2_k127_3767113_22 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 322.0
TLS2_k127_3767113_23 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 302.0
TLS2_k127_3767113_24 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 300.0
TLS2_k127_3767113_25 Putative bacterial sensory transduction regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001506 275.0
TLS2_k127_3767113_26 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002104 262.0
TLS2_k127_3767113_27 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001462 258.0
TLS2_k127_3767113_28 Belongs to the Fur family K09823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003315 242.0
TLS2_k127_3767113_29 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000005311 248.0
TLS2_k127_3767113_3 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1028.0
TLS2_k127_3767113_30 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000000000000001468 247.0
TLS2_k127_3767113_31 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000001061 190.0
TLS2_k127_3767113_32 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000004632 194.0
TLS2_k127_3767113_33 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.0000000000000000000000000000000000000000000000004142 184.0
TLS2_k127_3767113_34 Cytochrome c - - - 0.00000000000000000000000000000000000000009727 160.0
TLS2_k127_3767113_35 MerC mercury resistance protein - - - 0.0000000000000000000000000000000000000003903 152.0
TLS2_k127_3767113_36 L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.00000000000000000000000000000000009428 135.0
TLS2_k127_3767113_37 Membrane fusogenic activity K09806 - - 0.00000000000000000000000000000009575 127.0
TLS2_k127_3767113_38 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000002972 118.0
TLS2_k127_3767113_39 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000115 120.0
TLS2_k127_3767113_4 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 6.447e-273 845.0
TLS2_k127_3767113_40 - - - - 0.000000000000000000000003268 110.0
TLS2_k127_3767113_41 - - - - 0.000000000000000002018 85.0
TLS2_k127_3767113_42 - - - - 0.000000000000000007442 94.0
TLS2_k127_3767113_43 Protein of unknown function (DUF3309) - - - 0.00000000000000005175 88.0
TLS2_k127_3767113_44 - - - - 0.000000000000001078 87.0
TLS2_k127_3767113_46 Pilus assembly protein PilZ - - - 0.000000000356 65.0
TLS2_k127_3767113_49 Belongs to the UPF0235 family K09131 - - 0.000002397 56.0
TLS2_k127_3767113_5 protein conserved in bacteria - - - 3.533e-236 748.0
TLS2_k127_3767113_52 - - - - 0.0001707 49.0
TLS2_k127_3767113_6 Sugar (and other) transporter K08369 - - 7.693e-234 733.0
TLS2_k127_3767113_7 Sodium:solute symporter family - - - 9.144e-211 665.0
TLS2_k127_3767113_8 COG0729 Outer membrane protein K07278 - - 1.413e-198 639.0
TLS2_k127_3767113_9 DNA restriction-modification system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005725 611.0
TLS2_k127_3782238_0 Cytosol aminopeptidase family, catalytic domain K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002746 509.0
TLS2_k127_3782238_1 AAA domain K02282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 488.0
TLS2_k127_3782238_2 PFAM NLP P60 protein - - - 0.00000000000000000000000000000000000000000000678 168.0
TLS2_k127_3782238_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000001365 70.0
TLS2_k127_3785227_0 nitrogen fixation sensor protein fixL K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 468.0
TLS2_k127_3785227_1 small integral membrane protein - - - 0.00000000000000000000000000000000000000000000001274 177.0
TLS2_k127_3785227_2 part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes K14987 - - 0.0000000000000000000000000000000000000000000003911 169.0
TLS2_k127_3785227_3 KR domain - - - 0.0003688 44.0
TLS2_k127_3820725_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1167.0
TLS2_k127_3820725_1 Prolyl oligopeptidase K01322 - 3.4.21.26 5e-324 1008.0
TLS2_k127_3820725_10 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 7.824e-200 631.0
TLS2_k127_3820725_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 603.0
TLS2_k127_3820725_12 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 596.0
TLS2_k127_3820725_13 Pyrrolo-quinoline quinone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007681 598.0
TLS2_k127_3820725_14 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 597.0
TLS2_k127_3820725_15 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 570.0
TLS2_k127_3820725_16 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 568.0
TLS2_k127_3820725_17 dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 544.0
TLS2_k127_3820725_18 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000919 539.0
TLS2_k127_3820725_19 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 531.0
TLS2_k127_3820725_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 4.829e-294 908.0
TLS2_k127_3820725_20 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 520.0
TLS2_k127_3820725_21 Cell wall formation K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 503.0
TLS2_k127_3820725_22 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006639 491.0
TLS2_k127_3820725_23 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 459.0
TLS2_k127_3820725_24 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008232 383.0
TLS2_k127_3820725_25 cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 376.0
TLS2_k127_3820725_26 Protein of unknown function (DUF418) K07148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009097 375.0
TLS2_k127_3820725_27 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 370.0
TLS2_k127_3820725_28 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 294.0
TLS2_k127_3820725_29 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002163 274.0
TLS2_k127_3820725_3 X-Pro dipeptidyl-peptidase (S15 family) - - - 9.585e-288 897.0
TLS2_k127_3820725_30 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004769 265.0
TLS2_k127_3820725_31 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002371 261.0
TLS2_k127_3820725_32 Cell division protein FtsQ K03589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001255 269.0
TLS2_k127_3820725_33 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001094 252.0
TLS2_k127_3820725_34 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001624 258.0
TLS2_k127_3820725_35 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001716 266.0
TLS2_k127_3820725_36 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001657 242.0
TLS2_k127_3820725_37 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000000000000000000000107 241.0
TLS2_k127_3820725_38 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000005377 231.0
TLS2_k127_3820725_39 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000000000000000000000000000000000006668 226.0
TLS2_k127_3820725_4 Cell division protein FtsI penicillin-binding protein K03587 - 3.4.16.4 1.694e-240 771.0
TLS2_k127_3820725_40 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000006899 228.0
TLS2_k127_3820725_41 Glyoxalase-like domain K04750 - - 0.00000000000000000000000000000000000000000000000000000000000000335 221.0
TLS2_k127_3820725_42 Hpt domain K20976 - - 0.000000000000000000000000000000000000000000000000000000000000008665 219.0
TLS2_k127_3820725_43 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000000000001846 216.0
TLS2_k127_3820725_44 MgtC family K07507 - - 0.000000000000000000000000000000000000000000000000001028 192.0
TLS2_k127_3820725_45 - - - - 0.00000000000000000000000000000000000000000000000003762 185.0
TLS2_k127_3820725_46 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000002217 173.0
TLS2_k127_3820725_47 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.000000000000000000000000000000000000000000003177 169.0
TLS2_k127_3820725_48 - - - - 0.0000000000000000000000000000000000000000001506 173.0
TLS2_k127_3820725_49 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000000000000000000000001305 158.0
TLS2_k127_3820725_5 Belongs to the MurCDEF family K01924 - 6.3.2.8 2.064e-233 732.0
TLS2_k127_3820725_50 - - - - 0.000000000000000000000000000000000000001239 156.0
TLS2_k127_3820725_51 - - - - 0.00000000000000000000000000000000002413 149.0
TLS2_k127_3820725_52 PFAM regulatory protein ArsR - - - 0.00000000000000000000000000000001373 130.0
TLS2_k127_3820725_54 SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains. - - - 0.0000000000000000000000001158 116.0
TLS2_k127_3820725_55 - - - - 0.000000000000000000001155 100.0
TLS2_k127_3820725_56 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.000000000000000000139 90.0
TLS2_k127_3820725_57 - - - - 0.00000000000001041 85.0
TLS2_k127_3820725_58 BFD-like [2Fe-2S] binding domain K02192 - - 0.0000000000003643 71.0
TLS2_k127_3820725_59 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000000003472 76.0
TLS2_k127_3820725_6 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 8.246e-223 697.0
TLS2_k127_3820725_62 TIGRFAM TIGR02588 family protein - - - 0.00001253 56.0
TLS2_k127_3820725_63 DnaJ molecular chaperone homology domain - - - 0.00001428 57.0
TLS2_k127_3820725_64 - - - - 0.00004708 53.0
TLS2_k127_3820725_7 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 5.068e-216 679.0
TLS2_k127_3820725_8 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 6.901e-214 676.0
TLS2_k127_3820725_9 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 6.906e-209 659.0
TLS2_k127_382105_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1331.0
TLS2_k127_382105_1 DNA polymerase K02337 - 2.7.7.7 0.0 1315.0
TLS2_k127_382105_10 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 5.2e-200 636.0
TLS2_k127_382105_11 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 1.42e-198 624.0
TLS2_k127_382105_12 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 7.221e-194 614.0
TLS2_k127_382105_13 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 535.0
TLS2_k127_382105_14 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008639 493.0
TLS2_k127_382105_15 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003778 483.0
TLS2_k127_382105_16 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 474.0
TLS2_k127_382105_17 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 451.0
TLS2_k127_382105_18 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004752 416.0
TLS2_k127_382105_19 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 393.0
TLS2_k127_382105_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.713e-265 834.0
TLS2_k127_382105_20 Protein of unknown function (DUF3089) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 398.0
TLS2_k127_382105_21 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008784 387.0
TLS2_k127_382105_22 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 368.0
TLS2_k127_382105_23 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 370.0
TLS2_k127_382105_24 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 362.0
TLS2_k127_382105_25 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 349.0
TLS2_k127_382105_26 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 333.0
TLS2_k127_382105_27 cyclic nucleotide binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 328.0
TLS2_k127_382105_28 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 300.0
TLS2_k127_382105_29 phosphoserine phosphatase K01079 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 289.0
TLS2_k127_382105_3 cytochrome C K02198 - - 3.757e-260 816.0
TLS2_k127_382105_30 FOG TPR repeat, SEL1 subfamily K07126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003427 277.0
TLS2_k127_382105_31 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001922 267.0
TLS2_k127_382105_32 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000000000000000000000000002196 240.0
TLS2_k127_382105_34 Alkyl hydroperoxide reductase K02199 - - 0.000000000000000000000000000000000000000000000000000000001956 209.0
TLS2_k127_382105_35 Protein of unknown function (DUF3775) - - - 0.000000000000000000000000000000000000000000000000000002699 194.0
TLS2_k127_382105_36 PRC-barrel domain - - - 0.000000000000000000000000000000000000000000000000000003364 196.0
TLS2_k127_382105_37 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000001078 199.0
TLS2_k127_382105_38 - - - - 0.0000000000000000000000000000000000000000000000000005005 195.0
TLS2_k127_382105_39 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000000000002242 186.0
TLS2_k127_382105_4 Transport of potassium into the cell K03549 - - 3.425e-258 809.0
TLS2_k127_382105_40 2'-5' RNA ligase superfamily - - - 0.0000000000000000000000000000000000000000000000000981 183.0
TLS2_k127_382105_41 membrane - - - 0.00000000000000000000000000000000000000000000001166 179.0
TLS2_k127_382105_42 subunit of a heme lyase K02200 - - 0.00000000000000000000000000000000000000000000002342 179.0
TLS2_k127_382105_43 Histidine triad (HIT) protein - - - 0.000000000000000000000000000000000000000000007073 168.0
TLS2_k127_382105_44 - - - - 0.00000000000000000000000000000000000000000004074 169.0
TLS2_k127_382105_45 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.0000000000000000000000000000000000000000002348 173.0
TLS2_k127_382105_46 Cytochrome c biogenesis factor K02200 - - 0.0000000000000000000000000000000000000000003764 173.0
TLS2_k127_382105_47 - - - - 0.0000000000000000000000000000000000000006347 155.0
TLS2_k127_382105_48 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000002053 144.0
TLS2_k127_382105_49 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000007875 148.0
TLS2_k127_382105_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 2.522e-255 795.0
TLS2_k127_382105_50 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000008283 135.0
TLS2_k127_382105_51 - - - - 0.00000000000000000000000000002056 124.0
TLS2_k127_382105_52 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000001432 115.0
TLS2_k127_382105_6 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 1.953e-248 771.0
TLS2_k127_382105_7 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 9.675e-228 721.0
TLS2_k127_382105_8 Belongs to the glycosyl hydrolase 1 family - - - 2.081e-212 675.0
TLS2_k127_382105_9 Glucose / Sorbosone dehydrogenase - - - 1.684e-206 653.0
TLS2_k127_3824491_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 520.0
TLS2_k127_3824491_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 398.0
TLS2_k127_3824491_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 362.0
TLS2_k127_3824491_3 membrane K08973 - - 0.00000000000000000000000000000000000000000000000000000000006895 214.0
TLS2_k127_3824491_4 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000001511 192.0
TLS2_k127_3824491_5 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000704 65.0
TLS2_k127_3860357_0 - - - - 0.00000000000000000000000000000000000001125 154.0
TLS2_k127_3860357_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000003484 143.0
TLS2_k127_3860357_2 Tetratricopeptide repeat - - - 0.000000000000000008402 94.0
TLS2_k127_3902646_0 ABC transporter - - - 6.09e-290 897.0
TLS2_k127_3902646_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K20034 - 6.2.1.44 6.137e-277 859.0
TLS2_k127_3902646_10 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 408.0
TLS2_k127_3902646_11 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 332.0
TLS2_k127_3902646_12 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004938 282.0
TLS2_k127_3902646_13 Oligoketide cyclase lipid transport protein K18588 - - 0.00000000000000000000000000000000000000000000000000000000000000000007803 240.0
TLS2_k127_3902646_14 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000006984 233.0
TLS2_k127_3902646_15 Bacteriocin-protection protein - - - 0.00000000000000000000000000000000000000000000000000000000002806 211.0
TLS2_k127_3902646_16 HWE histidine kinase - - - 0.0000000000000000000000000000000000000000004642 164.0
TLS2_k127_3902646_17 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000007183 158.0
TLS2_k127_3902646_18 - - - - 0.00000000000000000000000000000000000005584 145.0
TLS2_k127_3902646_19 Ferredoxin K04755 - - 0.0000000000000000000000000000000000006585 145.0
TLS2_k127_3902646_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 7.243e-225 709.0
TLS2_k127_3902646_20 MAPEG family - - - 0.00000000000000000000000000000000007608 138.0
TLS2_k127_3902646_21 Domain of unknown function (DUF1905) - - - 0.00000000000000000000002084 102.0
TLS2_k127_3902646_22 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000002238 96.0
TLS2_k127_3902646_25 Belongs to the CinA family K03743 - 3.5.1.42 0.0005763 44.0
TLS2_k127_3902646_3 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 7.065e-200 631.0
TLS2_k127_3902646_4 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 4.404e-194 610.0
TLS2_k127_3902646_5 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 534.0
TLS2_k127_3902646_6 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 532.0
TLS2_k127_3902646_7 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 502.0
TLS2_k127_3902646_8 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006139 453.0
TLS2_k127_3902646_9 Alpha Beta K07018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007825 413.0
TLS2_k127_3924109_0 PFAM ABC transporter transmembrane region K06021,K13409,K20344 - 3.6.3.27 3.034e-205 666.0
TLS2_k127_3924109_1 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000004511 235.0
TLS2_k127_3924109_2 HlyD family secretion protein K13408 - - 0.0000000000000000000000000000000000000000000006167 183.0
TLS2_k127_3924109_3 COG3293 Transposase and inactivated derivatives K07492 - - 0.00000000000000000000000000000000000000000006986 178.0
TLS2_k127_3924109_4 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000007892 108.0
TLS2_k127_3924109_5 Peptidase, M61 - - - 0.00000000000000000001873 106.0
TLS2_k127_3924109_6 helix_turn_helix, arabinose operon control protein K07506 - - 0.00000000000005373 84.0
TLS2_k127_4018924_0 trisaccharide binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 534.0
TLS2_k127_4018924_1 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 420.0
TLS2_k127_4018924_2 PQQ-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 381.0
TLS2_k127_4018924_3 Belongs to the glutaminase family K01425 - 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 382.0
TLS2_k127_4018924_4 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000699 252.0
TLS2_k127_4018924_5 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000005291 195.0
TLS2_k127_4018924_6 - - - - 0.0000000000000004687 80.0
TLS2_k127_4018924_7 TspO/MBR family K05770 - - 0.000000002466 61.0
TLS2_k127_4138827_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1359.0
TLS2_k127_4138827_1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 6.604e-263 819.0
TLS2_k127_4138827_10 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000481 219.0
TLS2_k127_4138827_2 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 9.491e-238 741.0
TLS2_k127_4138827_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 7.963e-222 702.0
TLS2_k127_4138827_4 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002385 400.0
TLS2_k127_4138827_5 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 370.0
TLS2_k127_4138827_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 364.0
TLS2_k127_4138827_7 DNA polymerase K02337 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000003082 262.0
TLS2_k127_4138827_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001251 252.0
TLS2_k127_4138827_9 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000308 237.0
TLS2_k127_4177995_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1319.0
TLS2_k127_4177995_1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.0 1048.0
TLS2_k127_4177995_10 amino acid aldolase or racemase K20757 - 4.3.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 375.0
TLS2_k127_4177995_11 Belongs to the BI1 family K06890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 363.0
TLS2_k127_4177995_12 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009845 358.0
TLS2_k127_4177995_13 protein conserved in bacteria K09987 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 353.0
TLS2_k127_4177995_14 dienelactone hydrolase K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000525 310.0
TLS2_k127_4177995_15 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 290.0
TLS2_k127_4177995_16 Fructosamine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004021 284.0
TLS2_k127_4177995_17 N-formylglutamate amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007817 274.0
TLS2_k127_4177995_18 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001801 251.0
TLS2_k127_4177995_19 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000001044 249.0
TLS2_k127_4177995_2 Prolyl oligopeptidase family - - - 2.274e-284 889.0
TLS2_k127_4177995_20 Domain of unknown function (DUF4956) - - - 0.0000000000000000000000000000000000000000000000000000000000007975 218.0
TLS2_k127_4177995_21 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000005055 217.0
TLS2_k127_4177995_22 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000000000000000001316 191.0
TLS2_k127_4177995_23 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000001279 192.0
TLS2_k127_4177995_24 - - - - 0.0000000000000000000000000000000006907 135.0
TLS2_k127_4177995_25 response regulator K13589 - - 0.000000000000000000000000000003235 121.0
TLS2_k127_4177995_26 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.00000000000000000000000001705 110.0
TLS2_k127_4177995_27 - - - - 0.00000000000000000000000352 110.0
TLS2_k127_4177995_3 Peptidase, M28 - - - 2.748e-230 726.0
TLS2_k127_4177995_4 Belongs to the DEAD box helicase family - - - 8.278e-197 622.0
TLS2_k127_4177995_5 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 561.0
TLS2_k127_4177995_6 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 527.0
TLS2_k127_4177995_7 NADPH quinone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004231 467.0
TLS2_k127_4177995_8 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 413.0
TLS2_k127_4177995_9 PFAM SapC family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 394.0
TLS2_k127_418036_0 Vitamin K epoxide reductase family - - - 0.0 1077.0
TLS2_k127_418036_1 TonB-dependent Receptor Plug Domain - - - 3.4e-307 967.0
TLS2_k127_418036_10 pilus assembly protein TadB K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008845 421.0
TLS2_k127_418036_11 Cytochrome c1 K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008758 415.0
TLS2_k127_418036_12 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 402.0
TLS2_k127_418036_13 Belongs to the GST superfamily K11209 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016667,GO:0050896,GO:0055114 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 366.0
TLS2_k127_418036_14 protein conserved in bacteria K09973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 334.0
TLS2_k127_418036_15 photosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 304.0
TLS2_k127_418036_16 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009144 306.0
TLS2_k127_418036_17 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007256 296.0
TLS2_k127_418036_18 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 294.0
TLS2_k127_418036_19 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005344 287.0
TLS2_k127_418036_2 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 1.134e-286 894.0
TLS2_k127_418036_20 N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004885 243.0
TLS2_k127_418036_21 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000008982 213.0
TLS2_k127_418036_22 Pilus assembly protein CpaD K02281 - - 0.000000000000000000000000000000000000000000000000000000000006795 211.0
TLS2_k127_418036_23 protein conserved in bacteria K09973 - - 0.0000000000000000000000000000000000000000000000000014 193.0
TLS2_k127_418036_24 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000001262 115.0
TLS2_k127_418036_25 - - - - 0.0000000000000000000004021 107.0
TLS2_k127_418036_26 - - - - 0.0000000000000000007128 94.0
TLS2_k127_418036_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 3.459e-237 741.0
TLS2_k127_418036_4 Flp pilus assembly protein, ATPase CpaE K02282 - - 3.177e-233 725.0
TLS2_k127_418036_5 Sulfotransferase family - - - 4.276e-218 687.0
TLS2_k127_418036_6 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 589.0
TLS2_k127_418036_7 type II secretion system protein K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 544.0
TLS2_k127_418036_8 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 521.0
TLS2_k127_418036_9 coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 452.0
TLS2_k127_4241319_0 His Kinase A (phosphoacceptor) domain - - - 0.0 2033.0
TLS2_k127_4241319_1 DNA helicase K03657 - 3.6.4.12 0.0 1197.0
TLS2_k127_4241319_10 peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 532.0
TLS2_k127_4241319_11 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 513.0
TLS2_k127_4241319_12 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 496.0
TLS2_k127_4241319_13 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 473.0
TLS2_k127_4241319_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 464.0
TLS2_k127_4241319_15 Transcriptional regulator K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005873 447.0
TLS2_k127_4241319_16 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 447.0
TLS2_k127_4241319_17 Homocysteine S-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 416.0
TLS2_k127_4241319_18 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 415.0
TLS2_k127_4241319_19 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 379.0
TLS2_k127_4241319_2 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0 1175.0
TLS2_k127_4241319_20 serine acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 315.0
TLS2_k127_4241319_21 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 317.0
TLS2_k127_4241319_22 Fatty acid hydroxylase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 312.0
TLS2_k127_4241319_23 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 315.0
TLS2_k127_4241319_24 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 302.0
TLS2_k127_4241319_25 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007485 280.0
TLS2_k127_4241319_26 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001189 256.0
TLS2_k127_4241319_27 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000001595 216.0
TLS2_k127_4241319_28 DNA polymerase III K02339 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000003214 194.0
TLS2_k127_4241319_29 Ferric reductase like transmembrane component - - - 0.000000000000000000000000000000000000000000007454 169.0
TLS2_k127_4241319_3 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 2.25e-321 991.0
TLS2_k127_4241319_30 Protein of unknown function (DUF2794) - - - 0.00000000000000000000000000000000000000000001108 165.0
TLS2_k127_4241319_31 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.0000000000000000000000000000000000000000005555 159.0
TLS2_k127_4241319_32 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.0000000000000000000000000000000000000000429 157.0
TLS2_k127_4241319_33 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000007075 154.0
TLS2_k127_4241319_34 Belongs to the Nudix hydrolase family - - - 0.000000000000000000000000000003836 128.0
TLS2_k127_4241319_35 Peptidase propeptide and YPEB domain - - - 0.00000000000000000000000000007287 118.0
TLS2_k127_4241319_36 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000000000000000001087 111.0
TLS2_k127_4241319_4 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 9.008e-310 966.0
TLS2_k127_4241319_5 protein conserved in bacteria - - - 2.385e-261 818.0
TLS2_k127_4241319_6 Histidine kinase - - - 7.143e-260 820.0
TLS2_k127_4241319_7 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.077e-255 795.0
TLS2_k127_4241319_8 Major facilitator superfamily - - - 1.039e-195 618.0
TLS2_k127_4241319_9 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009481 606.0
TLS2_k127_4252264_0 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 439.0
TLS2_k127_4252264_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07484 - - 0.000000000000000000000000000000000000003408 152.0
TLS2_k127_4252264_2 Evidence 4 Homologs of previously reported genes of K07483 - - 0.00000000000000000000000000001565 121.0
TLS2_k127_4252264_3 IS66 Orf2 like protein K07484 - - 0.000000000000000000666 87.0
TLS2_k127_4252264_4 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000003417 59.0
TLS2_k127_43816_0 PFAM transposase mutator type - - - 1.659e-206 649.0
TLS2_k127_43816_1 - - - - 0.0000000000000002255 79.0
TLS2_k127_43816_2 Transposase and inactivated derivatives - - - 0.00006916 51.0
TLS2_k127_4425857_0 Dienelactone hydrolase family - - - 2.408e-276 865.0
TLS2_k127_4425857_1 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 576.0
TLS2_k127_4425857_2 - - - - 0.0000000000000000000000000000000000000000000000000000213 194.0
TLS2_k127_4425857_3 -acetyltransferase K06975 - - 0.0000000000000000000002216 106.0
TLS2_k127_4425857_4 SnoaL-like domain - - - 0.00000002914 64.0
TLS2_k127_4558579_0 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 346.0
TLS2_k127_4558579_1 - - - - 0.00000000000000000000000000000000000000000000000001144 181.0
TLS2_k127_4558579_2 - - - - 0.0000000000000002601 81.0
TLS2_k127_461787_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 2.472e-251 792.0
TLS2_k127_4834421_0 acyl-CoA dehydrogenase K00252 - 1.3.8.6 3.608e-204 644.0
TLS2_k127_4834421_1 PFAM Uncharacterised protein family (UPF0153) - - - 0.000000000000000000000000000000000000002312 153.0
TLS2_k127_4834421_2 Outer membrane receptor proteins, mostly Fe transport - - - 0.000000001147 59.0
TLS2_k127_4890377_0 Heat shock 70 kDa protein K04043 - - 0.0 1094.0
TLS2_k127_4890377_1 MaoC like domain K02618 - 1.2.1.91,3.3.2.12 0.0 1073.0
TLS2_k127_4890377_10 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 491.0
TLS2_k127_4890377_11 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 391.0
TLS2_k127_4890377_12 enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 379.0
TLS2_k127_4890377_13 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005612 361.0
TLS2_k127_4890377_14 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 282.0
TLS2_k127_4890377_15 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000004168 211.0
TLS2_k127_4890377_16 Phenylacetic acid degradation B K02610 - - 0.00000000000000000000000000000000000000000000001106 175.0
TLS2_k127_4890377_17 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000000004043 166.0
TLS2_k127_4890377_18 Thioesterase superfamily K02614 - - 0.0000000000000000000000000000000000000000001313 163.0
TLS2_k127_4890377_19 CBS domain - - - 0.0000000000000000000000000000000000000001138 154.0
TLS2_k127_4890377_2 Dicarboxylate transport - - - 5e-324 1024.0
TLS2_k127_4890377_20 Domain of unknown function (DUF4163) - - - 0.0000000000000000000000000000000000000002244 162.0
TLS2_k127_4890377_21 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000001026 132.0
TLS2_k127_4890377_22 protein conserved in bacteria K09978 - - 0.000000000000000000000000000006323 126.0
TLS2_k127_4890377_23 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.0000000000000000000000000003004 115.0
TLS2_k127_4890377_24 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000002056 114.0
TLS2_k127_4890377_25 Belongs to the UPF0758 family K03630 - - 0.0000000000000000002923 90.0
TLS2_k127_4890377_26 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0000000000000001138 85.0
TLS2_k127_4890377_3 Asparagine synthase K01953 - 6.3.5.4 3.786e-271 846.0
TLS2_k127_4890377_4 Prokaryotic glutathione synthetase, ATP-grasp domain - - - 1.731e-227 725.0
TLS2_k127_4890377_5 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.893e-219 691.0
TLS2_k127_4890377_6 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 586.0
TLS2_k127_4890377_7 Oxidoreductase FAD-binding domain K00523,K02613 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 520.0
TLS2_k127_4890377_8 PFAM Aminotransferase class I and II K00832 - 2.6.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 504.0
TLS2_k127_4890377_9 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 497.0
TLS2_k127_4908204_0 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005487 409.0
TLS2_k127_4908204_1 LysR substrate binding domain K03566 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006584 340.0
TLS2_k127_4951457_0 receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 586.0
TLS2_k127_4951457_1 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006244 319.0
TLS2_k127_4951457_2 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000001124 216.0
TLS2_k127_4951457_3 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000003088 216.0
TLS2_k127_4951457_4 LytTr DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000008865 190.0
TLS2_k127_4951457_5 LytTr DNA-binding domain - - - 0.00000000000000000000000000006661 129.0
TLS2_k127_4951457_6 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000006864 130.0
TLS2_k127_4951457_7 peroxidase K07223 - - 0.000000308 53.0
TLS2_k127_5001347_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1116.0
TLS2_k127_5001347_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0 1088.0
TLS2_k127_5001347_10 Inner membrane protein CreD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 484.0
TLS2_k127_5001347_11 Cytochrome p450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007384 469.0
TLS2_k127_5001347_12 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 429.0
TLS2_k127_5001347_13 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 420.0
TLS2_k127_5001347_14 D-amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009458 415.0
TLS2_k127_5001347_15 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 411.0
TLS2_k127_5001347_16 chemotaxis K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 392.0
TLS2_k127_5001347_17 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 379.0
TLS2_k127_5001347_18 COG0491 Zn-dependent hydrolases, including glyoxylases K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 372.0
TLS2_k127_5001347_19 glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 375.0
TLS2_k127_5001347_2 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 0.0 1040.0
TLS2_k127_5001347_20 ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008257 358.0
TLS2_k127_5001347_21 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 304.0
TLS2_k127_5001347_22 Domain of unknown function (DUF4130 K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 295.0
TLS2_k127_5001347_23 L,D-transpeptidase catalytic domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 306.0
TLS2_k127_5001347_24 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 294.0
TLS2_k127_5001347_25 Protein of unknown function (DUF2459) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003356 276.0
TLS2_k127_5001347_26 cytochrome C K08738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001925 262.0
TLS2_k127_5001347_27 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009114 249.0
TLS2_k127_5001347_28 Thioredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000005026 239.0
TLS2_k127_5001347_29 Protein of unknown function (DUF721) - - - 0.0000000000000000000000000000000000000000000000000000000000005748 225.0
TLS2_k127_5001347_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0 1034.0
TLS2_k127_5001347_30 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000000000000000000001384 177.0
TLS2_k127_5001347_31 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000001315 164.0
TLS2_k127_5001347_32 succinate dehydrogenase K00241 - - 0.0000000000000000000000000000000000000003776 158.0
TLS2_k127_5001347_33 - - - - 0.00000000000000000000000000000000000000741 157.0
TLS2_k127_5001347_34 succinate dehydrogenase activity K00242 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000005921 150.0
TLS2_k127_5001347_35 - - - - 0.00000000000000000000000000000000002512 142.0
TLS2_k127_5001347_36 Preprotein translocase subunit YajC K03210 - - 0.00000000000000000000000000000001096 130.0
TLS2_k127_5001347_37 - - - - 0.00000000000000000000000000000007025 129.0
TLS2_k127_5001347_38 PFAM VanZ - - - 0.00000000000000000000003471 103.0
TLS2_k127_5001347_4 TonB dependent receptor K16090 - - 1.316e-266 849.0
TLS2_k127_5001347_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.908e-238 747.0
TLS2_k127_5001347_6 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 6.835e-227 709.0
TLS2_k127_5001347_7 May be involved in recombinational repair of damaged DNA K03631 - - 1.513e-199 636.0
TLS2_k127_5001347_8 peptidase S10 serine carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009709 582.0
TLS2_k127_5001347_9 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003064 531.0
TLS2_k127_5003854_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1261.0
TLS2_k127_5003854_1 poly(R)-hydroxyalkanoic acid synthase K03821 - - 3.72e-274 855.0
TLS2_k127_5003854_10 DEAD DEAH box helicase K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 513.0
TLS2_k127_5003854_11 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 511.0
TLS2_k127_5003854_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 515.0
TLS2_k127_5003854_13 protein conserved in bacteria K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009668 497.0
TLS2_k127_5003854_14 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 490.0
TLS2_k127_5003854_15 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004095 484.0
TLS2_k127_5003854_16 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 443.0
TLS2_k127_5003854_17 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 441.0
TLS2_k127_5003854_18 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 421.0
TLS2_k127_5003854_19 MTH538 TIR-like domain (DUF1863) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 419.0
TLS2_k127_5003854_2 ATP-dependent DNA ligase K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 1.267e-272 846.0
TLS2_k127_5003854_20 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 390.0
TLS2_k127_5003854_21 Bacterial PH domain K08981 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007038 400.0
TLS2_k127_5003854_22 Asparaginase K13051 - 3.4.19.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 387.0
TLS2_k127_5003854_23 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003312 345.0
TLS2_k127_5003854_24 Cold shock K03704 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 343.0
TLS2_k127_5003854_25 endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 339.0
TLS2_k127_5003854_26 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 332.0
TLS2_k127_5003854_27 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000452 308.0
TLS2_k127_5003854_28 RarD protein K05786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 305.0
TLS2_k127_5003854_29 glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 284.0
TLS2_k127_5003854_3 single-stranded-DNA-specific exonuclease RecJ K07462 - - 3.159e-247 776.0
TLS2_k127_5003854_30 DNA mediated transformation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009043 299.0
TLS2_k127_5003854_31 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001458 271.0
TLS2_k127_5003854_32 Hydrolase K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004542 269.0
TLS2_k127_5003854_33 Domain of unknown function (DUF4893) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001092 263.0
TLS2_k127_5003854_34 EamA-like transporter family K15270 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000933 258.0
TLS2_k127_5003854_35 protein conserved in bacteria K09774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000163 255.0
TLS2_k127_5003854_36 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001866 253.0
TLS2_k127_5003854_37 endoribonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000002796 225.0
TLS2_k127_5003854_38 Protein conserved in bacteria K11719 - - 0.000000000000000000000000000000000000000000000000000000000000001484 224.0
TLS2_k127_5003854_39 Protein of unknown function (DUF1345) - - - 0.000000000000000000000000000000000000000000000000000000000000004591 224.0
TLS2_k127_5003854_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.733e-230 718.0
TLS2_k127_5003854_40 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000000000000000000000000000000008883 205.0
TLS2_k127_5003854_41 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000001973 203.0
TLS2_k127_5003854_42 Bacterial PH domain - - - 0.000000000000000000000000000000000000000000000000004778 187.0
TLS2_k127_5003854_43 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000000007453 172.0
TLS2_k127_5003854_44 response regulator K11443 - - 0.0000000000000000000000000000000000000000000001837 171.0
TLS2_k127_5003854_45 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000000000000000000002966 177.0
TLS2_k127_5003854_46 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000000000000005403 158.0
TLS2_k127_5003854_47 Small Multidrug Resistance protein K11741 - - 0.0000000000000000000000000000000000000000006624 159.0
TLS2_k127_5003854_48 - - - - 0.000000000000000000000000000000000000000001382 162.0
TLS2_k127_5003854_49 - - - - 0.000000000000000000000000000000000000000004485 158.0
TLS2_k127_5003854_5 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.863e-230 715.0
TLS2_k127_5003854_50 - - - - 0.0000000000000000000000000000000000000003109 153.0
TLS2_k127_5003854_51 Phasin protein - - - 0.000000000000000000000000000000000000009659 161.0
TLS2_k127_5003854_52 -acetyltransferase - - - 0.00000000000000000000000000003511 122.0
TLS2_k127_5003854_53 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000000007167 105.0
TLS2_k127_5003854_55 - - - - 0.00000000000000000006107 98.0
TLS2_k127_5003854_56 Protein of unknown function (DUF3572) - - - 0.000000000000000002937 87.0
TLS2_k127_5003854_57 membrane - - - 0.00000000000000004331 86.0
TLS2_k127_5003854_6 Aminotransferase K14261 - - 2.697e-214 671.0
TLS2_k127_5003854_7 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.71e-209 655.0
TLS2_k127_5003854_8 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 577.0
TLS2_k127_5003854_9 in Escherichia coli this protein forms a dimer and binds manganese K11532 - 3.1.3.11,3.1.3.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000171 520.0
TLS2_k127_5210453_0 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 552.0
TLS2_k127_5210453_1 Protease prsW family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008158 338.0
TLS2_k127_5302819_0 receptor K02014 - - 7.558e-304 951.0
TLS2_k127_5302819_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 6.939e-239 749.0
TLS2_k127_5302819_10 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 383.0
TLS2_k127_5302819_11 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 323.0
TLS2_k127_5302819_12 Riboflavin synthase K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002457 272.0
TLS2_k127_5302819_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002056 272.0
TLS2_k127_5302819_14 RpsU-divergently transcribed K18587 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008887 265.0
TLS2_k127_5302819_15 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000649 251.0
TLS2_k127_5302819_16 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000001611 213.0
TLS2_k127_5302819_17 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000001519 211.0
TLS2_k127_5302819_18 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000005126 203.0
TLS2_k127_5302819_19 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000001766 196.0
TLS2_k127_5302819_2 Iron permease FTR1 family K07243 - - 1.181e-217 693.0
TLS2_k127_5302819_20 Uncharacterized ACR, COG1399 - - - 0.00000000000000000000000000000000000000000000000000003178 193.0
TLS2_k127_5302819_21 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000000000000000000000000000000000000000001263 179.0
TLS2_k127_5302819_22 Small protein A (tmRNA-binding) - - - 0.000000000000000000000000000000000000000000001198 169.0
TLS2_k127_5302819_23 - - - - 0.0000000000000000000000000000000000000000009781 175.0
TLS2_k127_5302819_24 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000004854 157.0
TLS2_k127_5302819_25 Ubiquinol-cytochrome C chaperone K17662 - - 0.0000000000000000000000000000000000000838 150.0
TLS2_k127_5302819_26 Fasciclin - - - 0.00000000000000000000000000000005461 134.0
TLS2_k127_5302819_27 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000000000000000000004086 127.0
TLS2_k127_5302819_29 Antibiotic biosynthesis monooxygenase - - - 0.0000000000004212 68.0
TLS2_k127_5302819_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 1.291e-217 681.0
TLS2_k127_5302819_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 1.056e-201 632.0
TLS2_k127_5302819_5 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 604.0
TLS2_k127_5302819_6 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 553.0
TLS2_k127_5302819_7 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003444 528.0
TLS2_k127_5302819_8 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 505.0
TLS2_k127_5302819_9 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 482.0
TLS2_k127_5394957_0 Major Facilitator - - - 4.228e-237 745.0
TLS2_k127_5394957_1 6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009069 301.0
TLS2_k127_5394957_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002137 261.0
TLS2_k127_5394957_3 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000000000000000000000000000000000863 198.0
TLS2_k127_5394957_4 Protein of unknown function (DUF3833) - - - 0.0000000000000000000000009583 112.0
TLS2_k127_5394957_5 Recombinase zinc beta ribbon domain - - - 0.0000000003016 65.0
TLS2_k127_5509550_0 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 0.0 1244.0
TLS2_k127_5509550_1 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 0.0 1067.0
TLS2_k127_5509550_10 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 520.0
TLS2_k127_5509550_11 PBP superfamily domain K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 483.0
TLS2_k127_5509550_12 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 465.0
TLS2_k127_5509550_13 Phosphate ABC transporter substrate-binding protein K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 441.0
TLS2_k127_5509550_14 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 358.0
TLS2_k127_5509550_15 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 363.0
TLS2_k127_5509550_16 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004568 340.0
TLS2_k127_5509550_17 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 338.0
TLS2_k127_5509550_18 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004591 296.0
TLS2_k127_5509550_19 N-acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000002767 268.0
TLS2_k127_5509550_2 GTP-binding protein TypA K06207 - - 2.666e-310 962.0
TLS2_k127_5509550_20 Protein-disulfide isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001639 250.0
TLS2_k127_5509550_21 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008116 240.0
TLS2_k127_5509550_22 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000001287 220.0
TLS2_k127_5509550_23 COG3773 Cell wall hydrolyses involved in spore germination K01449 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000002819 210.0
TLS2_k127_5509550_24 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000306 209.0
TLS2_k127_5509550_25 EVE domain - - - 0.0000000000000000000000000000000000000000000000000000009865 194.0
TLS2_k127_5509550_26 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000001358 196.0
TLS2_k127_5509550_27 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000002274 187.0
TLS2_k127_5509550_28 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000000001968 161.0
TLS2_k127_5509550_3 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 1.976e-275 869.0
TLS2_k127_5509550_30 Regulatory protein MarR - - - 0.00008035 51.0
TLS2_k127_5509550_31 - - - - 0.0003847 46.0
TLS2_k127_5509550_32 Protein of unknown function (DUF3828) - - - 0.000838 46.0
TLS2_k127_5509550_4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.795e-233 728.0
TLS2_k127_5509550_5 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 1.559e-204 640.0
TLS2_k127_5509550_6 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 614.0
TLS2_k127_5509550_7 phosphate transport system permease K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 565.0
TLS2_k127_5509550_8 phosphate-selective porin K07221 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006617 535.0
TLS2_k127_5509550_9 Peptidase M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 530.0
TLS2_k127_5620509_0 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 312.0
TLS2_k127_5620509_1 Glycine dehydrogenase (aminomethyl-transferring) K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 302.0
TLS2_k127_5620509_2 gag-polyprotein putative aspartyl protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003468 272.0
TLS2_k127_5620509_3 Protein of unknown function (DUF938) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002737 263.0
TLS2_k127_5620509_4 PilZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004884 229.0
TLS2_k127_5620509_5 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000004861 190.0
TLS2_k127_5620509_6 Protein of unknown function (DUF454) K09790 - - 0.0000000000000000000000000000000000009482 143.0
TLS2_k127_5676745_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.101e-221 692.0
TLS2_k127_5676745_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 560.0
TLS2_k127_5676745_2 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000003771 237.0
TLS2_k127_5676745_3 dioxygenase of extradiol dioxygenase family K06991 - - 0.00000000000000000000000000000000000000000000000000000000000001355 218.0
TLS2_k127_5676745_4 membrane - - - 0.000000000000000000000000000000000000000004617 160.0
TLS2_k127_5698042_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.317e-276 858.0
TLS2_k127_5698042_1 Protein of unknown function (DUF3617) - - - 0.0004131 46.0
TLS2_k127_5741409_0 Amidohydrolase family - - - 0.0 1168.0
TLS2_k127_5741409_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 1.309e-235 741.0
TLS2_k127_5741409_10 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000001878 211.0
TLS2_k127_5741409_11 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000000000000000003246 196.0
TLS2_k127_5741409_12 - - - - 0.000000000000000000000000000000000000000004572 166.0
TLS2_k127_5741409_13 - - - - 0.00000000000000000000000000000000000007428 155.0
TLS2_k127_5741409_14 SWI complex, BAF60b domains - - - 0.0000000000000000000000000000006364 128.0
TLS2_k127_5741409_15 - - - - 0.00000000000000000000000001787 110.0
TLS2_k127_5741409_2 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 1.532e-200 633.0
TLS2_k127_5741409_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007081 442.0
TLS2_k127_5741409_4 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 345.0
TLS2_k127_5741409_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005649 308.0
TLS2_k127_5741409_6 proteins, homologs of microcin C7 resistance protein MccF K01297 - 3.4.17.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 305.0
TLS2_k127_5741409_7 Extensin-like protein C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003718 261.0
TLS2_k127_5741409_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000000009104 226.0
TLS2_k127_5741409_9 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000006002 233.0
TLS2_k127_5788698_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1166.0
TLS2_k127_5788698_1 acyl-CoA dehydrogenase K00252 - 1.3.8.6 8.976e-219 682.0
TLS2_k127_5788698_10 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 282.0
TLS2_k127_5788698_11 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000005217 262.0
TLS2_k127_5788698_12 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000002591 256.0
TLS2_k127_5788698_13 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000008564 231.0
TLS2_k127_5788698_14 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000004253 226.0
TLS2_k127_5788698_15 - - - - 0.000000000000000000000000000000000000000000004552 169.0
TLS2_k127_5788698_16 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000000000000000000006132 154.0
TLS2_k127_5788698_17 Outer membrane protein (OmpH-like) - - - 0.00000000000000000000000001944 115.0
TLS2_k127_5788698_2 receptor K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 610.0
TLS2_k127_5788698_3 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 553.0
TLS2_k127_5788698_4 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 464.0
TLS2_k127_5788698_5 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 435.0
TLS2_k127_5788698_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 386.0
TLS2_k127_5788698_7 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 344.0
TLS2_k127_5788698_8 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 328.0
TLS2_k127_5788698_9 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000722 312.0
TLS2_k127_5807498_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 4.889e-318 998.0
TLS2_k127_5807498_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.245e-272 848.0
TLS2_k127_5807498_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 359.0
TLS2_k127_5807498_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 346.0
TLS2_k127_5807498_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 295.0
TLS2_k127_5807498_13 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000000000000000000000001253 225.0
TLS2_k127_5807498_14 Sporulation related domain - - - 0.000000000000000000000000000000000000000000000000000000153 211.0
TLS2_k127_5807498_15 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000323 198.0
TLS2_k127_5807498_16 PFAM Acetyltransferase (GNAT) family K03395 - 2.3.1.60 0.0000000000000000000000000000000000000000000005138 177.0
TLS2_k127_5807498_17 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000000001648 120.0
TLS2_k127_5807498_18 protein secretion K03116 - - 0.0000000000000000000265 93.0
TLS2_k127_5807498_2 AFG1 family ATPase K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008571 531.0
TLS2_k127_5807498_20 - - - - 0.000006783 49.0
TLS2_k127_5807498_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 469.0
TLS2_k127_5807498_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 476.0
TLS2_k127_5807498_5 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 461.0
TLS2_k127_5807498_6 In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 446.0
TLS2_k127_5807498_7 beta-N-acetylhexosaminidase K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 432.0
TLS2_k127_5807498_8 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 392.0
TLS2_k127_5807498_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 375.0
TLS2_k127_5810252_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 331.0
TLS2_k127_5810252_1 Dehydrogenase K00020,K08319 - 1.1.1.31,1.1.1.411 0.00000000000000000000000000000000000000000000000000000000000000003497 233.0
TLS2_k127_5810252_2 ABC transporter substrate-binding protein - - - 0.00008879 48.0
TLS2_k127_5818047_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1030.0
TLS2_k127_5845993_0 aminopeptidase N K01256 - 3.4.11.2 0.0 1149.0
TLS2_k127_5845993_1 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003571 529.0
TLS2_k127_5845993_10 MobA-like NTP transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001165 258.0
TLS2_k127_5845993_11 transport system auxiliary component K18480 - - 0.0000000000000000000000000000000000000000000000000000006423 199.0
TLS2_k127_5845993_2 Belongs to the glycosyl hydrolase 43 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 510.0
TLS2_k127_5845993_3 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 480.0
TLS2_k127_5845993_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 440.0
TLS2_k127_5845993_5 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 432.0
TLS2_k127_5845993_6 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 412.0
TLS2_k127_5845993_7 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 319.0
TLS2_k127_5845993_8 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 317.0
TLS2_k127_5845993_9 Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine K01761 - 4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 301.0
TLS2_k127_6078393_0 His Kinase A (phosphoacceptor) domain - - - 0.0 1331.0
TLS2_k127_6078393_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 7.4e-323 996.0
TLS2_k127_6078393_10 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate - - - 0.0000000000000000000000000000000000000000682 156.0
TLS2_k127_6078393_11 - - - - 0.0000000000000000000000000189 111.0
TLS2_k127_6078393_12 - - - - 0.000000000000000000000001873 111.0
TLS2_k127_6078393_13 - - - - 0.00000000000000000000006465 103.0
TLS2_k127_6078393_15 Flp pilus assembly protein, pilin Flp K02651 - - 0.0000000000007203 71.0
TLS2_k127_6078393_2 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 2.166e-197 644.0
TLS2_k127_6078393_3 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 502.0
TLS2_k127_6078393_4 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 469.0
TLS2_k127_6078393_5 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 415.0
TLS2_k127_6078393_6 ATPase involved in DNA replication - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001113 284.0
TLS2_k127_6078393_7 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001418 250.0
TLS2_k127_6078393_8 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000003945 232.0
TLS2_k127_6078393_9 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000002972 183.0
TLS2_k127_6288412_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0 1168.0
TLS2_k127_6288412_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 2.932e-255 804.0
TLS2_k127_6288412_10 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 513.0
TLS2_k127_6288412_11 YjgP YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004552 496.0
TLS2_k127_6288412_12 Response regulator of the LytR AlgR family K02477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 466.0
TLS2_k127_6288412_13 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 469.0
TLS2_k127_6288412_14 exodeoxyribonuclease III K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 449.0
TLS2_k127_6288412_15 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 451.0
TLS2_k127_6288412_16 Putative peptidoglycan binding domain K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005036 447.0
TLS2_k127_6288412_17 YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005351 437.0
TLS2_k127_6288412_18 Diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 425.0
TLS2_k127_6288412_19 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 396.0
TLS2_k127_6288412_2 Histidine kinase - - - 3.503e-242 764.0
TLS2_k127_6288412_20 epimerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 363.0
TLS2_k127_6288412_21 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 337.0
TLS2_k127_6288412_22 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 321.0
TLS2_k127_6288412_23 Family of unknown function (DUF1028) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007788 289.0
TLS2_k127_6288412_24 COG2513 PEP phosphonomutase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 289.0
TLS2_k127_6288412_25 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000108 283.0
TLS2_k127_6288412_26 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005393 248.0
TLS2_k127_6288412_27 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000002981 239.0
TLS2_k127_6288412_28 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000003715 227.0
TLS2_k127_6288412_29 DNA-binding protein K11940 - - 0.00000000000000000000000000000000000000000000000000007751 188.0
TLS2_k127_6288412_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 4.746e-242 752.0
TLS2_k127_6288412_30 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000000000000000001019 186.0
TLS2_k127_6288412_31 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000001486 172.0
TLS2_k127_6288412_32 Histidine kinase - - - 0.0000000000000000000000000000000000000000005463 171.0
TLS2_k127_6288412_33 - - - - 0.000000000000000000000000000000000000000002344 160.0
TLS2_k127_6288412_34 Belongs to the HesB IscA family - - - 0.000000000000000000000000000000000000000005342 158.0
TLS2_k127_6288412_35 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000002534 159.0
TLS2_k127_6288412_36 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000001009 149.0
TLS2_k127_6288412_37 structural constituent of ribosome K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000003962 141.0
TLS2_k127_6288412_38 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000001312 120.0
TLS2_k127_6288412_39 acyl carrier protein - - - 0.00000000000000000000000000002103 119.0
TLS2_k127_6288412_4 leukotriene A-4 hydrolase - - - 1.957e-231 734.0
TLS2_k127_6288412_40 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000002634 99.0
TLS2_k127_6288412_41 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000008979 93.0
TLS2_k127_6288412_42 Recombinase zinc beta ribbon domain - - - 0.00000000001457 64.0
TLS2_k127_6288412_43 Winged helix DNA-binding domain - - - 0.00001921 53.0
TLS2_k127_6288412_5 Peptidase family M49 - - - 2.55e-225 711.0
TLS2_k127_6288412_6 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes K00639,K00652 - 2.3.1.29,2.3.1.47 7.116e-223 699.0
TLS2_k127_6288412_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 552.0
TLS2_k127_6288412_8 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 543.0
TLS2_k127_6288412_9 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 533.0
TLS2_k127_6306963_0 DNA polymerase K02337 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 552.0
TLS2_k127_6306963_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006807,GO:0006810,GO:0008104,GO:0008150,GO:0008152,GO:0015031,GO:0015399,GO:0015405,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0022804,GO:0022857,GO:0031224,GO:0032991,GO:0033036,GO:0042157,GO:0042160,GO:0042623,GO:0042626,GO:0042886,GO:0042953,GO:0043170,GO:0043190,GO:0043492,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901564,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 306.0
TLS2_k127_6306963_2 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000002084 61.0
TLS2_k127_6362206_0 acyl-CoA dehydrogenase - - - 7.892e-288 895.0
TLS2_k127_6362206_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 7.748e-197 618.0
TLS2_k127_6362206_2 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.00000000000000000000000000000000000000000000000000000001296 209.0
TLS2_k127_6362206_3 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000001319 150.0
TLS2_k127_6362206_4 Transcription elongation factor, GreA/GreB, C-term K06140 - - 0.0000000000000000000000000000000000001314 147.0
TLS2_k127_6454840_0 PFAM transposase, mutator K07493 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007335 304.0
TLS2_k127_6527514_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1035.0
TLS2_k127_6527514_1 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 7.158e-259 810.0
TLS2_k127_6527514_10 Bacterial low temperature requirement A protein (LtrA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 424.0
TLS2_k127_6527514_11 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002846 403.0
TLS2_k127_6527514_12 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 375.0
TLS2_k127_6527514_13 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 379.0
TLS2_k127_6527514_14 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 323.0
TLS2_k127_6527514_15 Protein of unknown function (DUF1428) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 318.0
TLS2_k127_6527514_16 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 307.0
TLS2_k127_6527514_17 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 289.0
TLS2_k127_6527514_18 PFAM 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003573 279.0
TLS2_k127_6527514_19 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006738 269.0
TLS2_k127_6527514_2 oxidase, subunit K00425 - 1.10.3.14 1.601e-220 693.0
TLS2_k127_6527514_20 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000006304 267.0
TLS2_k127_6527514_21 Glutathione S-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006868 260.0
TLS2_k127_6527514_22 molecular chaperone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007222 247.0
TLS2_k127_6527514_23 ribonuclease E activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000102 248.0
TLS2_k127_6527514_24 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000000000000003238 227.0
TLS2_k127_6527514_25 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000000000000000000004984 216.0
TLS2_k127_6527514_26 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000002484 204.0
TLS2_k127_6527514_27 Lactoylglutathione lyase K07032 - - 0.00000000000000000000000000000000000000000000001804 175.0
TLS2_k127_6527514_28 NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - 0.0000000000000000000000000000000000000000000001133 174.0
TLS2_k127_6527514_29 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000000000000000000000000001311 163.0
TLS2_k127_6527514_3 COG1253 Hemolysins and related proteins containing CBS domains K03699 - - 2.352e-202 638.0
TLS2_k127_6527514_30 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000000001885 143.0
TLS2_k127_6527514_31 - - - - 0.000000000000000000000000000000001238 136.0
TLS2_k127_6527514_32 Belongs to the BolA IbaG family K05527 - - 0.00000000000000000000000000000199 126.0
TLS2_k127_6527514_33 Uncharacterized protein conserved in bacteria (DUF2093) - - - 0.00000000000000000001751 92.0
TLS2_k127_6527514_35 - - - - 0.0000000003068 64.0
TLS2_k127_6527514_4 Aerobic cobaltochelatase subunit CobS K09882 - 6.6.1.2 6.552e-195 611.0
TLS2_k127_6527514_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 616.0
TLS2_k127_6527514_6 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007971 603.0
TLS2_k127_6527514_7 oxidase, subunit K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 527.0
TLS2_k127_6527514_8 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 472.0
TLS2_k127_6527514_9 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 439.0
TLS2_k127_6570467_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 2.588e-227 719.0
TLS2_k127_6570467_1 Belongs to the CarB family K01955 - 6.3.5.5 1.482e-198 625.0
TLS2_k127_6570467_2 Belongs to the CarA family K01956 - 6.3.5.5 3.305e-197 621.0
TLS2_k127_6570467_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002155 256.0
TLS2_k127_6570467_4 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000000000000002387 203.0
TLS2_k127_6619584_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000007055 121.0
TLS2_k127_6619584_1 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000005989 120.0
TLS2_k127_6619584_2 - - - - 0.0003709 52.0
TLS2_k127_6623256_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1780.0
TLS2_k127_6623256_1 ATP-dependent DNA helicase RecG K03655 - 3.6.4.12 0.0 1035.0
TLS2_k127_6623256_10 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 503.0
TLS2_k127_6623256_11 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002859 446.0
TLS2_k127_6623256_12 protein conserved in bacteria K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 422.0
TLS2_k127_6623256_13 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 373.0
TLS2_k127_6623256_14 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006505 351.0
TLS2_k127_6623256_15 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 324.0
TLS2_k127_6623256_16 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000005015 231.0
TLS2_k127_6623256_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000001422 222.0
TLS2_k127_6623256_18 Domain of unknown function (DUF2383) - - - 0.00000000000000000000000000000000000000000000000000000003094 201.0
TLS2_k127_6623256_19 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000000000000000000000007798 195.0
TLS2_k127_6623256_2 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.42e-284 885.0
TLS2_k127_6623256_20 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000002179 170.0
TLS2_k127_6623256_21 Putative inner membrane exporter, YdcZ K09936 - - 0.00000000000000000000000000000000000312 142.0
TLS2_k127_6623256_22 response regulator - - - 0.0000000000000000000000000000000001493 147.0
TLS2_k127_6623256_23 Flavinator of succinate dehydrogenase K09159 - - 0.00000000000000000000000000000004207 130.0
TLS2_k127_6623256_24 Pfam:DUF1049 K08992 - - 0.000000000000000000003973 95.0
TLS2_k127_6623256_25 PFAM blue (type 1) copper domain protein - - - 0.00000000000008796 77.0
TLS2_k127_6623256_3 Acetyl-coenzyme A transporter 1 K08218 - - 3.05e-284 881.0
TLS2_k127_6623256_4 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 2.632e-261 818.0
TLS2_k127_6623256_5 Protein of unknown function (DUF1343) - - - 5.897e-217 677.0
TLS2_k127_6623256_6 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 609.0
TLS2_k127_6623256_7 beta-lactamase K01467 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 567.0
TLS2_k127_6623256_8 epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 526.0
TLS2_k127_6623256_9 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 515.0
TLS2_k127_6627089_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1266.0
TLS2_k127_6627089_1 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 - 1.17.4.1 1.697e-288 892.0
TLS2_k127_6627089_10 Protein of unknown function (DUF3617) - - - 0.00000000000000000000000000000000000000001396 159.0
TLS2_k127_6627089_11 Cupin - - - 0.000000000000000000000000000000000000004729 150.0
TLS2_k127_6627089_12 Protein of unknown function (DUF3617) - - - 0.0000000000001259 78.0
TLS2_k127_6627089_2 epoxide hydrolase K21159 - - 2.268e-234 731.0
TLS2_k127_6627089_3 Castor and Pollux, part of voltage-gated ion channel - - - 1.334e-215 686.0
TLS2_k127_6627089_4 peptidase S10 serine carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 331.0
TLS2_k127_6627089_5 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007729 268.0
TLS2_k127_6627089_6 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004279 258.0
TLS2_k127_6627089_7 COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - 0.0000000000000000000000000000000000000000000000000000000001372 214.0
TLS2_k127_6627089_8 Putative MetA-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000005909 205.0
TLS2_k127_6627089_9 - - - - 0.000000000000000000000000000000000000000000000000000002241 202.0
TLS2_k127_6677661_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1374.0
TLS2_k127_6677661_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 366.0
TLS2_k127_6677661_10 Dopa 4,5-dioxygenase family K10253 - - 0.000000000000000000000000000000000000000001769 157.0
TLS2_k127_6677661_11 AntiSigma factor - - - 0.00000000000000000000000000005599 130.0
TLS2_k127_6677661_12 - - - - 0.0000000000000000000575 90.0
TLS2_k127_6677661_13 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000000000000000005934 90.0
TLS2_k127_6677661_14 Ion channel - - - 0.000000000000000007826 89.0
TLS2_k127_6677661_16 - - - - 0.0001224 53.0
TLS2_k127_6677661_2 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 314.0
TLS2_k127_6677661_3 Protein phosphatase 2A homologues, catalytic domain. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 317.0
TLS2_k127_6677661_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 292.0
TLS2_k127_6677661_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002252 276.0
TLS2_k127_6677661_6 COG1226 Kef-type K transport systems K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004926 273.0
TLS2_k127_6677661_7 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000742 243.0
TLS2_k127_6677661_8 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000001011 236.0
TLS2_k127_6677661_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000000000000000000000000000001668 201.0
TLS2_k127_6678608_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1061.0
TLS2_k127_6678608_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1023.0
TLS2_k127_6678608_10 ABC transporter, ATP-binding protein K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 455.0
TLS2_k127_6678608_11 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009522 439.0
TLS2_k127_6678608_12 molecular chaperone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008504 424.0
TLS2_k127_6678608_13 Carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 417.0
TLS2_k127_6678608_14 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 404.0
TLS2_k127_6678608_15 ABC-type Na efflux pump, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 332.0
TLS2_k127_6678608_16 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006421 304.0
TLS2_k127_6678608_17 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 294.0
TLS2_k127_6678608_18 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 293.0
TLS2_k127_6678608_19 COG0346 Lactoylglutathione lyase and related lyases K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000005158 227.0
TLS2_k127_6678608_2 receptor - - - 3.079e-238 753.0
TLS2_k127_6678608_20 Domain of unknown function (DUF4396) - - - 0.000000000000000000000000000000000000000000000000000000000000005275 220.0
TLS2_k127_6678608_21 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000003853 201.0
TLS2_k127_6678608_22 redox protein, regulator of disulfide bond formation K04063 - - 0.0000000000000000000000000000000000000000000000000000001972 197.0
TLS2_k127_6678608_23 transcriptional - - - 0.0000000000000000000000000000000000000000000000000006431 191.0
TLS2_k127_6678608_24 Uracil-DNA glycosylase superfamily - - - 0.000000000000000000000000000000000000000000000000003339 194.0
TLS2_k127_6678608_25 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate - - - 0.00000000000000000000000000000000000000056 151.0
TLS2_k127_6678608_27 - - - - 0.00000000000000000000000000000000000002737 151.0
TLS2_k127_6678608_28 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000000000001 139.0
TLS2_k127_6678608_29 Metal-sensitive transcriptional repressor K21600 - - 0.000000000000000000000000000002294 125.0
TLS2_k127_6678608_3 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 6.355e-216 678.0
TLS2_k127_6678608_30 Transcriptional regulator K07729 - - 0.00000000000000000000004081 107.0
TLS2_k127_6678608_32 Tetratricopeptide repeats - - - 0.000000000000000006731 94.0
TLS2_k127_6678608_4 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000711 586.0
TLS2_k127_6678608_5 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 584.0
TLS2_k127_6678608_6 Glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 554.0
TLS2_k127_6678608_7 Conserved TM helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000752 542.0
TLS2_k127_6678608_8 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007123 479.0
TLS2_k127_6678608_9 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006262 456.0
TLS2_k127_6727425_0 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 0.0 1472.0
TLS2_k127_6727425_1 5-methyltetrahydrofolate--homocysteine methyltransferase K00548 - 2.1.1.13 0.0 1343.0
TLS2_k127_6727425_10 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 479.0
TLS2_k127_6727425_11 Na -driven multidrug efflux pump K03327 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 478.0
TLS2_k127_6727425_12 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009359 467.0
TLS2_k127_6727425_13 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009915 475.0
TLS2_k127_6727425_14 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 421.0
TLS2_k127_6727425_15 ArsR family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000757 392.0
TLS2_k127_6727425_16 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006041 356.0
TLS2_k127_6727425_17 conserved secreted or membrane protein precursor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 293.0
TLS2_k127_6727425_18 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000001928 177.0
TLS2_k127_6727425_19 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000002518 151.0
TLS2_k127_6727425_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 3.901e-244 759.0
TLS2_k127_6727425_20 - - - - 0.00000000000000000000000000000000008873 139.0
TLS2_k127_6727425_21 response to cobalt ion - - - 0.000007556 53.0
TLS2_k127_6727425_3 Thiol disulfide interchange protein - - - 1.247e-243 772.0
TLS2_k127_6727425_4 signal peptide peptidase K04773 - - 1.53e-201 645.0
TLS2_k127_6727425_5 Metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 625.0
TLS2_k127_6727425_6 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 581.0
TLS2_k127_6727425_7 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 554.0
TLS2_k127_6727425_8 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004443 542.0
TLS2_k127_6727425_9 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 506.0
TLS2_k127_674441_0 Domain of unknown function DUF87 K06915 - - 9.542e-292 918.0
TLS2_k127_674441_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 6.432e-217 677.0
TLS2_k127_674441_10 PFAM GtrA family protein - - - 0.000000000000000000000000000000000000003223 154.0
TLS2_k127_674441_11 COG0671 Membrane-associated phospholipid phosphatase - - - 0.00000000000000000000000000000000000001106 158.0
TLS2_k127_674441_12 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000005082 130.0
TLS2_k127_674441_13 invasion associated locus B - - - 0.00000000000000000000000002484 119.0
TLS2_k127_674441_14 - - - - 0.00000000000006282 75.0
TLS2_k127_674441_2 Glycosyl transferase family 2 K20534 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 545.0
TLS2_k127_674441_3 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 525.0
TLS2_k127_674441_4 synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 495.0
TLS2_k127_674441_5 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 412.0
TLS2_k127_674441_6 oligosaccharyl transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 350.0
TLS2_k127_674441_7 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 344.0
TLS2_k127_674441_8 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007119 269.0
TLS2_k127_674441_9 helicase K17675 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000517 237.0
TLS2_k127_6910803_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 0.0 1091.0
TLS2_k127_6910803_1 TonB dependent receptor - - - 0.0 1089.0
TLS2_k127_6910803_10 Histidine kinase K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 373.0
TLS2_k127_6910803_11 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 348.0
TLS2_k127_6910803_12 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 334.0
TLS2_k127_6910803_13 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006206 304.0
TLS2_k127_6910803_14 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001855 276.0
TLS2_k127_6910803_15 - - - - 0.00000000000000000000000000000000000000000000000000000000006706 210.0
TLS2_k127_6910803_16 GcrA cell cycle regulator K13583 - - 0.000000000000000000000000000000000000000000000000000000005041 198.0
TLS2_k127_6910803_17 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.0000000000000000000000000000000000000000000000000000009089 208.0
TLS2_k127_6910803_18 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000004791 198.0
TLS2_k127_6910803_19 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000107 202.0
TLS2_k127_6910803_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 2.122e-244 758.0
TLS2_k127_6910803_20 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000000000002175 141.0
TLS2_k127_6910803_21 DoxX - - - 0.00000000000000000000000000000005455 130.0
TLS2_k127_6910803_22 GcrA cell cycle regulator K13583 - - 0.000000000000000000000000000004737 125.0
TLS2_k127_6910803_23 CHRD domain - - - 0.000000000000000000000000002059 120.0
TLS2_k127_6910803_25 - - - - 0.000000000000000000002502 98.0
TLS2_k127_6910803_26 NlpC/P60 family - - - 0.000000000000000002521 91.0
TLS2_k127_6910803_27 Membrane-bound lysozyme-inhibitor of c-type lysozyme - - - 0.000000000631 64.0
TLS2_k127_6910803_29 - - - - 0.0000000786 59.0
TLS2_k127_6910803_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 1.393e-230 720.0
TLS2_k127_6910803_4 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 6.86e-208 651.0
TLS2_k127_6910803_5 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007136 591.0
TLS2_k127_6910803_6 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 468.0
TLS2_k127_6910803_7 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 452.0
TLS2_k127_6910803_8 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 432.0
TLS2_k127_6910803_9 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 425.0
TLS2_k127_6925223_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006547 453.0
TLS2_k127_6925223_1 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006733 379.0
TLS2_k127_6925223_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 376.0
TLS2_k127_6925223_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 326.0
TLS2_k127_6925223_4 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000003299 197.0
TLS2_k127_6925223_5 Redoxin - - - 0.000000000000000000000000000000000000000000001501 171.0
TLS2_k127_6925223_6 - - - - 0.0000000000000000000001081 101.0
TLS2_k127_6925223_8 Diguanylate cyclase, GGDEF domain - - - 0.000000000002959 74.0
TLS2_k127_6954431_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1132.0
TLS2_k127_6968273_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1380.0
TLS2_k127_6968273_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 1.535e-219 690.0
TLS2_k127_6968273_10 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 319.0
TLS2_k127_6968273_11 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000001218 239.0
TLS2_k127_6968273_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003443 239.0
TLS2_k127_6968273_13 membrane protein (homolog of Drosophila rhomboid) - - - 0.000000000000000000000000000000000000000000000000000000000025 211.0
TLS2_k127_6968273_14 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000001101 198.0
TLS2_k127_6968273_15 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000003884 206.0
TLS2_k127_6968273_16 Protein required for attachment to host cells - - - 0.000000000000000000000000000000000000000000000004914 179.0
TLS2_k127_6968273_17 Septum formation initiator - - - 0.0000000000000000000000000000000000000001131 152.0
TLS2_k127_6968273_18 Belongs to the CarB family K01955 - 6.3.5.5 0.000000000000000000000000000000000242 132.0
TLS2_k127_6968273_19 EF hand - - - 0.000000000000000000000000000000001055 136.0
TLS2_k127_6968273_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 4.201e-209 657.0
TLS2_k127_6968273_20 - - - - 0.000000000000000000000000000000007444 134.0
TLS2_k127_6968273_21 Domain of unknown function (DUF4170) - - - 0.000000000000000000000000000005807 120.0
TLS2_k127_6968273_22 ergosterol biosynthetic process K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000002295 123.0
TLS2_k127_6968273_23 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000000007142 76.0
TLS2_k127_6968273_24 - - - - 0.0000000000004072 74.0
TLS2_k127_6968273_27 - - - - 0.0004414 48.0
TLS2_k127_6968273_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 5.031e-207 653.0
TLS2_k127_6968273_4 Peptidase, M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 602.0
TLS2_k127_6968273_5 DNA repair photolyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 580.0
TLS2_k127_6968273_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 556.0
TLS2_k127_6968273_7 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 368.0
TLS2_k127_6968273_8 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 342.0
TLS2_k127_6968273_9 Belongs to the carbohydrate kinase PfkB family K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008383 318.0
TLS2_k127_7040782_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1353.0
TLS2_k127_7040782_1 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 1.218e-266 841.0
TLS2_k127_7040782_10 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 568.0
TLS2_k127_7040782_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 491.0
TLS2_k127_7040782_12 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 394.0
TLS2_k127_7040782_13 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 383.0
TLS2_k127_7040782_14 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 312.0
TLS2_k127_7040782_15 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 302.0
TLS2_k127_7040782_16 Phage shock protein A K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 305.0
TLS2_k127_7040782_17 PhzC PhzF - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 299.0
TLS2_k127_7040782_18 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003449 274.0
TLS2_k127_7040782_19 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001819 279.0
TLS2_k127_7040782_2 Outer membrane receptor proteins, mostly Fe transport - - - 2.475e-230 739.0
TLS2_k127_7040782_20 Protein of unknown function (DUF541) K09807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007704 249.0
TLS2_k127_7040782_21 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000002059 226.0
TLS2_k127_7040782_22 Nudix hydrolase - - - 0.0000000000000000000000000000000000000000000000000001115 192.0
TLS2_k127_7040782_23 Protein of unknown function (DUF1153) - - - 0.00000000000000000000000000000000000000000000000002345 179.0
TLS2_k127_7040782_24 HxlR-like helix-turn-helix - - - 0.00000000000000000000000000000000000000000000000005426 180.0
TLS2_k127_7040782_25 Protein of unknown function (DUF3297) - - - 0.000000000000000000000000000000002128 131.0
TLS2_k127_7040782_26 Transglycosylase associated protein - - - 0.00000000000000000000000000000000242 130.0
TLS2_k127_7040782_27 phosphoglycerate mutase - - - 0.000000000000000000000000000001019 126.0
TLS2_k127_7040782_28 Transglycosylase associated protein - - - 0.0000000000000000000000000001374 123.0
TLS2_k127_7040782_29 MerC mercury resistance protein - - - 0.00000000000000000000002916 104.0
TLS2_k127_7040782_3 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.964e-226 710.0
TLS2_k127_7040782_30 - - - - 0.00000000000000002581 84.0
TLS2_k127_7040782_31 positive regulation of macromolecule biosynthetic process K03973 - - 0.0000000000000001776 89.0
TLS2_k127_7040782_32 - - - - 0.00000002414 62.0
TLS2_k127_7040782_4 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 4.079e-215 673.0
TLS2_k127_7040782_5 chromate transporter K07240 - - 4.011e-195 624.0
TLS2_k127_7040782_6 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000412 610.0
TLS2_k127_7040782_7 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 594.0
TLS2_k127_7040782_8 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 594.0
TLS2_k127_7040782_9 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 565.0
TLS2_k127_7147917_0 BlaR1 peptidase M56 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003326 421.0
TLS2_k127_7147917_1 Penicillinase repressor - - - 0.0000000000000000000000000000000000000000000001063 173.0
TLS2_k127_7147917_2 Resolvase, N terminal domain - - - 0.000000000006586 66.0
TLS2_k127_715238_0 Major Facilitator Superfamily K03535 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 595.0
TLS2_k127_715238_1 Penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 590.0
TLS2_k127_715238_2 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003249 316.0
TLS2_k127_715238_3 Cro/C1-type HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000001393 193.0
TLS2_k127_715238_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000001619 197.0
TLS2_k127_715238_5 - - - - 0.00000000000000000000000000000003156 136.0
TLS2_k127_7181051_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 3.804e-227 710.0
TLS2_k127_7181051_1 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 317.0
TLS2_k127_7181051_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007177 303.0
TLS2_k127_7181051_3 Dicarboxylate transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000001707 252.0
TLS2_k127_7181051_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000001561 64.0
TLS2_k127_7260395_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 331.0
TLS2_k127_7260395_1 - - - - 0.00000000000000000000000000000000000000001096 157.0
TLS2_k127_7260395_2 Bacterial PH domain - - - 0.000000000000000000000000000000000002466 143.0
TLS2_k127_7260395_3 - - - - 0.0000000000003594 73.0
TLS2_k127_7260395_4 Peptidase family M23 - - - 0.0000000001517 67.0
TLS2_k127_7336477_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.0 1094.0
TLS2_k127_7336477_1 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.0 1075.0
TLS2_k127_7336477_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 3.876e-194 619.0
TLS2_k127_7336477_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 610.0
TLS2_k127_7336477_12 peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004564 562.0
TLS2_k127_7336477_13 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006324 520.0
TLS2_k127_7336477_14 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 397.0
TLS2_k127_7336477_15 NADH dehydrogenase K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 361.0
TLS2_k127_7336477_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000497 366.0
TLS2_k127_7336477_17 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 329.0
TLS2_k127_7336477_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002903 321.0
TLS2_k127_7336477_19 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007035 303.0
TLS2_k127_7336477_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.093e-296 915.0
TLS2_k127_7336477_20 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005011 268.0
TLS2_k127_7336477_21 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001604 288.0
TLS2_k127_7336477_22 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000845 199.0
TLS2_k127_7336477_23 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000000000001041 181.0
TLS2_k127_7336477_24 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000000000000005034 167.0
TLS2_k127_7336477_25 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000006006 170.0
TLS2_k127_7336477_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000000002038 157.0
TLS2_k127_7336477_27 Preprotein translocase subunit SecG K03075 - - 0.000000000000000000000000002988 115.0
TLS2_k127_7336477_28 Protein of unknown function (DUF1467) - - - 0.0000000000000000000002012 108.0
TLS2_k127_7336477_29 membrane metal-binding protein K02238 - - 0.000000000001889 71.0
TLS2_k127_7336477_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 3.038e-257 802.0
TLS2_k127_7336477_30 - - - - 0.0000000000376 64.0
TLS2_k127_7336477_31 - - - - 0.00000000008995 75.0
TLS2_k127_7336477_32 - - - - 0.00000002654 56.0
TLS2_k127_7336477_33 PilZ domain - - - 0.00000009462 59.0
TLS2_k127_7336477_34 membrane metal-binding protein K02238 - - 0.0000009008 53.0
TLS2_k127_7336477_4 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 1.965e-251 786.0
TLS2_k127_7336477_5 Belongs to the citrate synthase family K01647 - 2.3.3.1 3.451e-246 764.0
TLS2_k127_7336477_6 metallo-beta-lactamase K12574 - - 1.236e-243 764.0
TLS2_k127_7336477_7 methyl-accepting chemotaxis protein K03406 - - 1.065e-222 698.0
TLS2_k127_7336477_8 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 3.283e-214 674.0
TLS2_k127_7336477_9 domain protein - - - 7.188e-200 647.0
TLS2_k127_7388295_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1101.0
TLS2_k127_7388295_1 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 6.92e-293 915.0
TLS2_k127_7388295_10 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000148 257.0
TLS2_k127_7388295_11 Belongs to the UPF0260 family K09160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003259 245.0
TLS2_k127_7388295_12 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.00000000000000000000000000000000000000000000000000000000000000005535 227.0
TLS2_k127_7388295_13 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000001714 224.0
TLS2_k127_7388295_14 DNA repair protein MmcB-like - - - 0.000000000000000000000000000000000000000000000000000000000000004212 220.0
TLS2_k127_7388295_15 COG3773 Cell wall hydrolyses involved in spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000005048 220.0
TLS2_k127_7388295_16 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.0000000000000000000000000000000000000000000000000000000001995 207.0
TLS2_k127_7388295_17 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000000000000000006065 209.0
TLS2_k127_7388295_18 DUF218 domain - - - 0.0000000000000000000000000000000000000000000000000000005923 208.0
TLS2_k127_7388295_19 Cell division protein K09811 - - 0.000000000000000000000000000000000000000000007093 187.0
TLS2_k127_7388295_2 usher protein - - - 6.201e-285 900.0
TLS2_k127_7388295_20 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000002586 163.0
TLS2_k127_7388295_21 Domain of unknown function (DUF4402) - - - 0.000000000000000000000000000000000000000001843 161.0
TLS2_k127_7388295_22 Ankyrin repeat - - - 0.0000000000000000000000000000000000000003928 155.0
TLS2_k127_7388295_23 zinc-ribbon domain - - - 0.00000000000000000000000000000000000009018 153.0
TLS2_k127_7388295_24 Domain of unknown function (DUF4402) - - - 0.0000000000000000000000003394 111.0
TLS2_k127_7388295_25 Protein of unknown function (DUF1491) - - - 0.00000000000000000000002845 102.0
TLS2_k127_7388295_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 548.0
TLS2_k127_7388295_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006384 400.0
TLS2_k127_7388295_5 Transcriptional regulator K07110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 350.0
TLS2_k127_7388295_6 cell division K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 342.0
TLS2_k127_7388295_7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006989 334.0
TLS2_k127_7388295_8 COG3121 P pilus assembly protein, chaperone PapD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005106 327.0
TLS2_k127_7388295_9 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000007109 268.0
TLS2_k127_7393003_0 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 1.573e-195 623.0
TLS2_k127_7393003_1 Oligopeptidase F K08602 - - 0.000000000000000000000000000000001565 133.0
TLS2_k127_7396597_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 0.0 1020.0
TLS2_k127_7396597_1 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009073 578.0
TLS2_k127_7396597_10 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000002422 210.0
TLS2_k127_7396597_11 - - - - 0.0000000000000001942 83.0
TLS2_k127_7396597_12 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000857 53.0
TLS2_k127_7396597_2 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 574.0
TLS2_k127_7396597_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 332.0
TLS2_k127_7396597_4 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 322.0
TLS2_k127_7396597_5 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006279 284.0
TLS2_k127_7396597_6 Prolyl 4-hydroxylase alpha subunit homologues. K07336 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004895 278.0
TLS2_k127_7396597_7 Alkyl hydroperoxide reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003512 256.0
TLS2_k127_7396597_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000001482 219.0
TLS2_k127_7396597_9 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000000003283 208.0
TLS2_k127_7408356_0 Peptidase family M3 K01284 - 3.4.15.5 0.0 1019.0
TLS2_k127_7408356_1 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 2.331e-298 920.0
TLS2_k127_7408356_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 411.0
TLS2_k127_7408356_11 amino acid K03294,K03759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 376.0
TLS2_k127_7408356_12 Belongs to the NadC ModD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 364.0
TLS2_k127_7408356_13 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002612 354.0
TLS2_k127_7408356_14 PFAM inositol monophosphatase K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 297.0
TLS2_k127_7408356_15 Binds to the 23S rRNA K02939 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001353 277.0
TLS2_k127_7408356_16 XRE family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005864 260.0
TLS2_k127_7408356_17 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001821 253.0
TLS2_k127_7408356_18 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000009976 211.0
TLS2_k127_7408356_19 Galactose oxidase, central domain - - - 0.000000000000000000000000000000000000000000000000000000000238 213.0
TLS2_k127_7408356_2 acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 1.421e-274 871.0
TLS2_k127_7408356_20 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000004927 201.0
TLS2_k127_7408356_21 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000000000000000000000000000000005693 196.0
TLS2_k127_7408356_22 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000003539 190.0
TLS2_k127_7408356_23 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000002363 173.0
TLS2_k127_7408356_24 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000002138 169.0
TLS2_k127_7408356_25 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000000000000003402 138.0
TLS2_k127_7408356_26 GtrA-like protein - - - 0.00000000000000000000001391 106.0
TLS2_k127_7408356_27 - - - - 0.00001418 50.0
TLS2_k127_7408356_29 elongation factor G K02355 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - 0.0004054 48.0
TLS2_k127_7408356_3 2-nitropropane dioxygenase - - - 2.03e-270 837.0
TLS2_k127_7408356_4 Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA K00253 - 1.3.8.4 2.526e-214 668.0
TLS2_k127_7408356_5 Ring hydroxylating alpha subunit (catalytic domain) - - - 1.125e-207 652.0
TLS2_k127_7408356_6 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 572.0
TLS2_k127_7408356_7 Aminoglycoside phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005985 562.0
TLS2_k127_7408356_8 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 546.0
TLS2_k127_7408356_9 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 423.0
TLS2_k127_7439828_0 Carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 582.0
TLS2_k127_7439828_1 Peptidase, M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 563.0
TLS2_k127_7439828_10 - - - - 0.0000000000000000000000000000009926 126.0
TLS2_k127_7439828_12 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000000008557 78.0
TLS2_k127_7439828_13 Putative auto-transporter adhesin, head GIN domain - - - 0.000002504 56.0
TLS2_k127_7439828_2 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 468.0
TLS2_k127_7439828_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007169 452.0
TLS2_k127_7439828_4 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 375.0
TLS2_k127_7439828_5 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 303.0
TLS2_k127_7439828_6 Auxin Efflux Carrier K07088 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004658 280.0
TLS2_k127_7439828_7 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000001129 245.0
TLS2_k127_7439828_8 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000003159 199.0
TLS2_k127_7439828_9 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000000000006026 131.0
TLS2_k127_760184_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1114.0
TLS2_k127_760184_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1e-323 997.0
TLS2_k127_760184_10 dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008879 533.0
TLS2_k127_760184_11 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006434 499.0
TLS2_k127_760184_12 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 495.0
TLS2_k127_760184_13 Polynucleotide adenylyltransferase K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 460.0
TLS2_k127_760184_14 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007502 452.0
TLS2_k127_760184_15 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003416 430.0
TLS2_k127_760184_16 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 437.0
TLS2_k127_760184_17 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 422.0
TLS2_k127_760184_18 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004695 414.0
TLS2_k127_760184_19 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 399.0
TLS2_k127_760184_2 Oxidoreductase - - - 6.122e-278 863.0
TLS2_k127_760184_20 MotA TolQ ExbB proton channel K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 379.0
TLS2_k127_760184_21 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 377.0
TLS2_k127_760184_22 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 374.0
TLS2_k127_760184_23 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006508 364.0
TLS2_k127_760184_24 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 349.0
TLS2_k127_760184_25 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 349.0
TLS2_k127_760184_26 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 339.0
TLS2_k127_760184_27 COG1538 Outer membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005715 353.0
TLS2_k127_760184_28 Putative Flp pilus-assembly TadE/G-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 334.0
TLS2_k127_760184_29 transcriptional regulator, XRE family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 316.0
TLS2_k127_760184_3 Penicillin-binding Protein K05366 - 2.4.1.129,3.4.16.4 4.394e-276 869.0
TLS2_k127_760184_30 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 314.0
TLS2_k127_760184_31 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 309.0
TLS2_k127_760184_32 enoyl-CoA hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 303.0
TLS2_k127_760184_33 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003459 282.0
TLS2_k127_760184_34 aspartate racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001353 274.0
TLS2_k127_760184_35 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005866 259.0
TLS2_k127_760184_36 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001717 260.0
TLS2_k127_760184_37 periplasmic protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009593 261.0
TLS2_k127_760184_38 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001711 248.0
TLS2_k127_760184_39 protein conserved in bacteria K09986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000007247 247.0
TLS2_k127_760184_4 GGDEF domain - - - 5.276e-233 734.0
TLS2_k127_760184_40 HlyD family secretion protein K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000000003383 246.0
TLS2_k127_760184_41 COG1226 Kef-type K transport systems K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000001907 238.0
TLS2_k127_760184_42 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000002559 237.0
TLS2_k127_760184_43 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000055 240.0
TLS2_k127_760184_44 Nudix hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000001932 223.0
TLS2_k127_760184_45 Biopolymer K03559 - - 0.000000000000000000000000000000000000000000000000000000000004157 211.0
TLS2_k127_760184_46 Biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000000000000000000004033 190.0
TLS2_k127_760184_47 Protein of unknown function (DUF4230) - - - 0.0000000000000000000000000000000000000000000000000005292 194.0
TLS2_k127_760184_48 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000000000004481 182.0
TLS2_k127_760184_49 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000000000000000000000000001548 190.0
TLS2_k127_760184_5 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 6.55e-214 672.0
TLS2_k127_760184_50 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.000000000000000000000000000000000000000000000002805 178.0
TLS2_k127_760184_51 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000000000000001061 174.0
TLS2_k127_760184_52 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000001048 171.0
TLS2_k127_760184_53 - - - - 0.000000000000000000000000000000000000000001089 164.0
TLS2_k127_760184_54 Domain of unknown function (DUF1476) - - - 0.000000000000000000000000000000000000000004357 156.0
TLS2_k127_760184_55 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000114 142.0
TLS2_k127_760184_56 Belongs to the BolA IbaG family - - - 0.0000000000000000000000000001784 119.0
TLS2_k127_760184_57 - - - - 0.00000000000000000000008663 104.0
TLS2_k127_760184_58 SnoaL-like domain - - - 0.000000000000000000002009 101.0
TLS2_k127_760184_59 TadE-like protein - - - 0.00000000000000000009281 95.0
TLS2_k127_760184_6 Belongs to the GPI family K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 8.722e-196 621.0
TLS2_k127_760184_60 TadE-like protein - - - 0.000000000000000004255 90.0
TLS2_k127_760184_61 Domain of unknown function (DUF4402) - - - 0.00000000000000006133 87.0
TLS2_k127_760184_62 - - - - 0.0000000000000001272 87.0
TLS2_k127_760184_63 - - - - 0.000000000002109 74.0
TLS2_k127_760184_64 - - - - 0.000000002199 67.0
TLS2_k127_760184_65 Histidine kinase - - - 0.00001576 58.0
TLS2_k127_760184_66 lysine biosynthetic process via aminoadipic acid - - - 0.0009923 43.0
TLS2_k127_760184_7 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 607.0
TLS2_k127_760184_8 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009584 599.0
TLS2_k127_760184_9 Toxic anion resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 602.0
TLS2_k127_776556_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1365.0
TLS2_k127_776556_1 Transport of potassium into the cell K03549 - - 2.762e-250 787.0
TLS2_k127_776556_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000004088 199.0
TLS2_k127_776556_11 protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - 0.000000000000000000000003424 105.0
TLS2_k127_776556_2 Peptidase family M1 domain - - - 4.09e-219 689.0
TLS2_k127_776556_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 609.0
TLS2_k127_776556_4 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 500.0
TLS2_k127_776556_5 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007549 454.0
TLS2_k127_776556_6 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 419.0
TLS2_k127_776556_7 Domain of unknown function (DUF4118) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009728 414.0
TLS2_k127_776556_8 Putative S-adenosyl-L-methionine-dependent methyltransferase K18164 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 392.0
TLS2_k127_776556_9 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006201 339.0
TLS2_k127_784478_0 AsmA-like C-terminal region K07289 - - 0.000000000000000000009628 108.0
TLS2_k127_784478_1 COG1178 ABC-type Fe3 transport system, permease component K02011 - - 0.00000000000000000008989 91.0
TLS2_k127_807623_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 490.0
TLS2_k127_807623_1 PAS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 471.0
TLS2_k127_962216_0 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0 1147.0
TLS2_k127_962216_1 Bacterial protein of unknown function (DUF853) K06915 - - 8.186e-235 741.0
TLS2_k127_962216_10 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 404.0
TLS2_k127_962216_11 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 392.0
TLS2_k127_962216_12 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 383.0
TLS2_k127_962216_13 Competence protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003141 255.0
TLS2_k127_962216_14 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.000000000000000000000000000000000000000000000000000000000000000000003967 238.0
TLS2_k127_962216_15 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000001213 193.0
TLS2_k127_962216_16 Colicin V production protein K03558 - - 0.0000000000000000000000000000000000000000000000002318 181.0
TLS2_k127_962216_17 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000009552 156.0
TLS2_k127_962216_18 ErfK ybiS ycfS ynhG family protein K19234 - - 0.00000000000000000000000000000000000008414 151.0
TLS2_k127_962216_19 TIR domain - - - 0.00000000000000000000000000000000001014 156.0
TLS2_k127_962216_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 3.904e-225 704.0
TLS2_k127_962216_20 NifU homolog involved in Fe-S cluster formation - - - 0.000000000000000000000000000000002811 136.0
TLS2_k127_962216_21 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000000000001326 125.0
TLS2_k127_962216_22 Cold-shock protein K03704 - - 0.00000000000000000000000001583 111.0
TLS2_k127_962216_23 Cold-shock protein - - - 0.0000000000000000000006581 100.0
TLS2_k127_962216_24 - - - - 0.000000000006167 70.0
TLS2_k127_962216_25 - - - - 0.0000000001727 71.0
TLS2_k127_962216_27 - - - - 0.00002064 51.0
TLS2_k127_962216_28 Sel1-like repeats. K07126 - - 0.0005064 46.0
TLS2_k127_962216_3 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 2.397e-209 674.0
TLS2_k127_962216_4 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 622.0
TLS2_k127_962216_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 573.0
TLS2_k127_962216_6 peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 561.0
TLS2_k127_962216_7 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 515.0
TLS2_k127_962216_8 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 497.0
TLS2_k127_962216_9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 472.0
TLS2_k127_968751_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 346.0
TLS2_k127_968751_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000008929 167.0
TLS2_k127_968751_2 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000002333 140.0
TLS2_k127_987686_0 Pseudouridine synthase K06177 - 5.4.99.28,5.4.99.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002312 283.0
TLS2_k127_987686_1 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000734 259.0
TLS2_k127_987686_2 membrane K12340 - - 0.0000000000000000000000000000000000000000000000000001063 188.0
TLS2_k127_987686_3 chain release factor K15034 - - 0.0000000000000000000000000000000000000000000004116 175.0
TLS2_k127_987686_4 protein conserved in bacteria K09991 - - 0.0000000000000000000000000000000000003739 149.0
TLS2_k127_987686_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.000000000000000002151 86.0